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Helen E. Scharfman - Publications

Affiliations: 
Columbia University, New York, NY 
Area:
Epilepsy
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Year Citation  Score
2023 Lisgaras CP, Scharfman HE. High Frequency Oscillations (>250Hz) Outnumber Interictal Spikes in Preclinical Studies of Alzheimer's Disease. Biorxiv : the Preprint Server For Biology. PMID 37961135 DOI: 10.1101/2023.10.30.564797  0.761
2023 Lisgaras CP, Scharfman HE. Interictal spikes in Alzheimer's disease: Preclinical evidence for dominance of the dentate gyrus and cholinergic control by the medial septum. Neurobiology of Disease. 187: 106294. PMID 37714307 DOI: 10.1016/j.nbd.2023.106294  0.773
2023 Whitebirch AC, Santoro B, Barnett A, Lisgaras CP, Scharfman HE, Siegelbaum SA. Reduced Cholecystokinin-Expressing Interneuron Input Contributes to Disinhibition of the Hippocampal CA2 Region in a Mouse Model of Temporal Lobe Epilepsy. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 43: 6930-6949. PMID 37643861 DOI: 10.1523/JNEUROSCI.2091-22.2023  0.801
2023 Jain S, LaFrancois JJ, Gerencer K, Botterill JJ, Kennedy M, Criscuolo C, Scharfman HE. Increasing adult neurogenesis protects mice from epilepsy. Biorxiv : the Preprint Server For Biology. PMID 37502909 DOI: 10.1101/2023.07.08.548217  0.329
2023 Lisgaras CP, Scharfman HE. Interictal Spikes in Animal Models of Alzheimer's Disease: Dominance of the Dentate Gyrus and Cholinergic Control by Medial Septum. Biorxiv : the Preprint Server For Biology. PMID 37163065 DOI: 10.1101/2023.04.24.537999  0.774
2023 Rosenberg EC, Chamberland S, Bazelot M, Nebet ER, Wang X, McKenzie S, Jain S, Greenhill S, Wilson M, Marley N, Salah A, Bailey S, Patra PH, Rose R, Chenouard N, ... ... Scharfman HE, et al. Cannabidiol modulates excitatory-inhibitory ratio to counter hippocampal hyperactivity. Neuron. PMID 36787750 DOI: 10.1016/j.neuron.2023.01.018  0.339
2022 Lisgaras CP, Scharfman HE. High Frequency Oscillations (250-500Hz) in Animal Models of Alzheimer's Disease and Two Animal Models of Epilepsy. Epilepsia. PMID 36346209 DOI: 10.1111/epi.17462  0.757
2022 Lisgaras CP, Scharfman HE. Robust chronic convulsive seizures, high frequency oscillations, and human seizure onset patterns in an intrahippocampal kainic acid model in mice. Neurobiology of Disease. 166: 105637. PMID 35091040 DOI: 10.1016/j.nbd.2022.105637  0.791
2021 Lu YL, Scharfman HE. New Insights and Methods for Recording and Imaging Spontaneous Spreading Depolarizations and Seizure-Like Events in Mouse Hippocampal Slices. Frontiers in Cellular Neuroscience. 15: 761423. PMID 34899190 DOI: 10.3389/fncel.2021.761423  0.307
2021 Ma Y, Bayguinov PO, McMahon SM, Scharfman HE, Jackson MB. Direct synaptic excitation between hilar mossy cells revealed with a targeted voltage sensor. Hippocampus. PMID 34478219 DOI: 10.1002/hipo.23386  0.301
2020 Stephens GS, Fu CH, St Romain CP, Zheng Y, Botterill JJ, Scharfman HE, Liu Y, Chin J. Genes Bound by ΔFosB in Different Conditions With Recurrent Seizures Regulate Similar Neuronal Functions. Frontiers in Neuroscience. 14: 472. PMID 32536852 DOI: 10.3389/Fnins.2020.00472  0.423
2020 Scharfman H. Does BDNF Contribute to Temporal Lobe Epilepsy? Epilepsy Currents. 2: 92-94. PMID 15309154 DOI: 10.1046/J.1535-7597.2002.T01-1-00033.X  0.446
2020 Scharfman H. A Novel Animal Model of Epilepsy Caused by Inhibiting Neuronal Activity during Development. Epilepsy Currents. 2: 127-128. PMID 15309141 DOI: 10.1046/J.1535-7597.2002.T01-1-00048.X  0.419
2020 Scharfman H. Upregulation of Multidrug Resistance Transporters in the Epileptic Brain. Epilepsy Currents. 2: 200-202. PMID 15309119 DOI: 10.1046/J.1535-7597.2002.00076.X  0.331
2020 Scharfman H. The "Reel" Pathology of Temporal Lobe Epilepsy. Epilepsy Currents. 2: 196-197. PMID 15309117 DOI: 10.1046/J.1535-7597.2002.00074.X  0.414
2019 Botterill JJ, Lu YL, LaFrancois JJ, Bernstein HL, Alcantara-Gonzalez D, Jain S, Leary P, Scharfman HE. An Excitatory and Epileptogenic Effect of Dentate Gyrus Mossy Cells in a Mouse Model of Epilepsy. Cell Reports. 29: 2875-2889.e6. PMID 31775052 DOI: 10.1016/J.Celrep.2019.10.100  0.468
2019 Bernstein HL, Lu YL, Botterill JJ, Scharfman HE. Novelty and Novel Objects Increase c-Fos Immunoreactivity in Mossy Cells in the Mouse Dentate Gyrus. Neural Plasticity. 2019: 1815371. PMID 31534449 DOI: 10.1155/2019/1815371  0.328
2019 Fu CH, Iascone DM, Petrof I, Hazra A, Zhang X, Pyfer MS, Tosi U, Corbett BF, Cai J, Lee J, Park J, Iacovitti L, Scharfman HE, Enikolopov G, Chin J. Early Seizure Activity Accelerates Depletion of Hippocampal Neural Stem Cells and Impairs Spatial Discrimination in an Alzheimer's Disease Model. Cell Reports. 27: 3741-3751.e4. PMID 31242408 DOI: 10.1016/J.Celrep.2019.05.101  0.428
2019 Scharfman HE. The Dentate Gyrus and Temporal Lobe Epilepsy: An "Exciting" Era. Epilepsy Currents. 1535759719855952. PMID 31232111 DOI: 10.1177/1535759719855952  0.381
2019 Luna VM, Anacker C, Burghardt NS, Khandaker H, Andreu V, Millette A, Leary P, Ravenelle R, Jimenez JC, Mastrodonato A, Denny CA, Fenton AA, Scharfman HE, Hen R. Adult-born hippocampal neurons bidirectionally modulate entorhinal inputs into the dentate gyrus. Science (New York, N.Y.). 364: 578-583. PMID 31073064 DOI: 10.1126/Science.Aat8789  0.378
2019 Jain S, LaFrancois JJ, Botterill JJ, Alcantara-Gonzalez D, Scharfman HE. Adult neurogenesis in the mouse dentate gyrus protects the hippocampus from neuronal injury following severe seizures. Hippocampus. PMID 30672046 DOI: 10.1002/Hipo.23062  0.407
2018 Scharfman HE. Controlling learning and epilepsy together. Science (New York, N.Y.). 359: 740-741. PMID 29449476 DOI: 10.1126/science.aas8993  0.378
2017 Scharfman HE. Advances in understanding hilar mossy cells of the dentate gyrus. Cell and Tissue Research. PMID 29222692 DOI: 10.1007/s00441-017-2750-5  0.404
2017 Kanner AM, Scharfman H, Jette N, Anagnostou E, Bernard C, Camfield C, Camfield P, Legg K, Dinstein I, Giacobe P, Friedman A, Pohlmann-Eden B. Epilepsy as a Network Disorder (1): What can we learn from other network disorders such as autistic spectrum disorder and mood disorders? Epilepsy & Behavior : E&B. PMID 29107450 DOI: 10.1016/J.Yebeh.2017.09.014  0.302
2017 Harte-Hargrove LC, French JA, Pitkänen A, Galanopoulou AS, Whittemore V, Scharfman HE. Common data elements for preclinical epilepsy research: Standards for data collection and reporting. A TASK3 report of the AES/ILAE Translational Task Force of the ILAE. Epilepsia. 58: 78-86. PMID 29105074 DOI: 10.1111/epi.13906  0.34
2017 Scharfman HE, Kanner AM, Friedman A, Blümcke I, Crocker CE, Cendes F, Diaz-Arrastia R, Förstl H, Fenton AA, Grace AA, Palop J, Morrison J, Nehlig A, Prasad A, Wilcox KS, et al. Epilepsy as a Network Disorder (2): What can we learn from other network disorders such as dementia and schizophrenia, and what are the implications for translational research? Epilepsy & Behavior : E&B. PMID 29097123 DOI: 10.1016/J.Yebeh.2017.09.016  0.318
2017 You JC, Muralidharan K, Park JW, Petrof I, Pyfer MS, Corbett BF, LaFrancois JJ, Zheng Y, Zhang X, Mohila CA, Yoshor D, Rissman RA, Nestler EJ, Scharfman HE, Chin J. Epigenetic suppression of hippocampal calbindin-D28k by ΔFosB drives seizure-related cognitive deficits. Nature Medicine. PMID 29035369 DOI: 10.1038/Nm.4413  0.427
2017 Magagna-Poveda A, Moretto JN, Scharfman HE. Increased gyrification and aberrant adult neurogenesis of the dentate gyrus in adult rats. Brain Structure & Function. PMID 28656372 DOI: 10.1007/s00429-017-1457-4  0.465
2017 Bermudez-Hernandez K, Lu YL, Moretto J, Jain S, LaFrancois JJ, Duffy AM, Scharfman HE. Hilar granule cells of the mouse dentate gyrus: effects of age, septotemporal location, strain, and selective deletion of the proapoptotic gene BAX. Brain Structure & Function. PMID 28314928 DOI: 10.1007/S00429-017-1391-5  0.679
2017 Moretto JN, Duffy ÁM, Scharfman HE. Acute restraint stress decreases c-fos immunoreactivity in hilar mossy cells of the adult dentate gyrus. Brain Structure & Function. PMID 28190104 DOI: 10.1007/S00429-016-1349-Z  0.652
2017 Scharfman HE, MacLusky NJ. Sex differences in hippocampal area CA3 pyramidal cells. Journal of Neuroscience Research. 95: 563-575. PMID 27870399 DOI: 10.1002/jnr.23927  0.343
2016 Scharfman HE. The enigmatic mossy cell of the dentate gyrus. Nature Reviews. Neuroscience. PMID 27466143 DOI: 10.1038/nrn.2016.87  0.428
2016 Mendell AL, Atwi S, Bailey CD, McCloskey D, Scharfman HE, MacLusky NJ. Expansion of mossy fibers and CA3 apical dendritic length accompanies the fall in dendritic spine density after gonadectomy in male, but not female, rats. Brain Structure & Function. PMID 27283589 DOI: 10.1007/s00429-016-1237-6  0.723
2016 Kam K, Duffy ÁM, Moretto J, LaFrancois JJ, Scharfman HE. Interictal spikes during sleep are an early defect in the Tg2576 mouse model of β-amyloid neuropathology. Scientific Reports. 6: 20119. PMID 26818394 DOI: 10.1038/Srep20119  0.781
2016 Drew LJ, Kheirbek MA, Luna VM, Denny CA, Cloidt MA, Wu MV, Jain S, Scharfman HE, Hen R. Activation of local inhibitory circuits in the dentate gyrus by adult-born neurons. Hippocampus. 26: 763-78. PMID 26662922 DOI: 10.1002/Hipo.22557  0.366
2016 Atwi S, McMahon D, Scharfman H, MacLusky NJ. Androgen Modulation of Hippocampal Structure and Function. The Neuroscientist : a Review Journal Bringing Neurobiology, Neurology and Psychiatry. 22: 46-60. PMID 25416742 DOI: 10.1177/1073858414558065  0.402
2015 Scharfman HE, Myers CE. Corruption of the dentate gyrus by "dominant" granule cells: Implications for dentate gyrus function in health and disease. Neurobiology of Learning and Memory. PMID 26391451 DOI: 10.1016/j.nlm.2015.09.005  0.348
2015 Scharfman HE, Bernstein HL. Potential implications of a monosynaptic pathway from mossy cells to adult-born granule cells of the dentate gyrus. Frontiers in Systems Neuroscience. 9: 112. PMID 26347618 DOI: 10.3389/fnsys.2015.00112  0.45
2015 Blackstad JS, Osen KK, Scharfman HE, Storm-Mathisen J, Blackstad TW, Leergaard TB. Observations on hippocampal mossy cells in mink (Neovison vison) with special reference to dendrites ascending to the granular and molecular layers. Hippocampus. PMID 26286893 DOI: 10.1002/Hipo.22518  0.398
2015 D'Amour J, Magagna-Poveda A, Moretto J, Friedman D, LaFrancois JJ, Pearce P, Fenton AA, MacLusky NJ, Scharfman HE. Interictal spike frequency varies with ovarian cycle stage in a rat model of epilepsy. Experimental Neurology. 269: 102-19. PMID 25864929 DOI: 10.1016/J.Expneurol.2015.04.003  0.409
2015 Cho KO, Lybrand ZR, Ito N, Brulet R, Tafacory F, Zhang L, Good L, Ure K, Kernie SG, Birnbaum SG, Scharfman HE, Eisch AJ, Hsieh J. Aberrant hippocampal neurogenesis contributes to epilepsy and associated cognitive decline. Nature Communications. 6: 6606. PMID 25808087 DOI: 10.1038/Ncomms7606  0.426
2015 Scharfman HE. Neuroscience. Metabolic control of epilepsy. Science (New York, N.Y.). 347: 1312-3. PMID 25792315 DOI: 10.1126/science.aaa9607  0.329
2015 Harte-Hargrove LC, Varga-Wesson A, Duffy AM, Milner TA, Scharfman HE. Opioid receptor-dependent sex differences in synaptic plasticity in the hippocampal mossy fiber pathway of the adult rat. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 35: 1723-38. PMID 25632146 DOI: 10.1523/Jneurosci.0820-14.2015  0.644
2015 Iyengar SS, LaFrancois JJ, Friedman D, Drew LJ, Denny CA, Burghardt NS, Wu MV, Hsieh J, Hen R, Scharfman HE. Suppression of adult neurogenesis increases the acute effects of kainic acid. Experimental Neurology. 264: 135-49. PMID 25476494 DOI: 10.1016/J.Expneurol.2014.11.009  0.449
2015 Duffy AM, Morales-Corraliza J, Bermudez-Hernandez KM, Schaner MJ, Magagna-Poveda A, Mathews PM, Scharfman HE. Entorhinal cortical defects in Tg2576 mice are present as early as 2-4 months of age. Neurobiology of Aging. 36: 134-48. PMID 25109765 DOI: 10.1016/J.Neurobiolaging.2014.07.001  0.66
2014 Scharfman HE, Buckmaster PS. Preface. Advances in Experimental Medicine and Biology. 813: xv-xviii. PMID 25371938 DOI: 10.1007/b107409  0.508
2014 VonDran MW, LaFrancois J, Padow VA, Friedman WJ, Scharfman HE, Milner TA, Hempstead BL. p75NTR, but not proNGF, is upregulated following status epilepticus in mice. Asn Neuro. 6. PMID 25290065 DOI: 10.1177/1759091414552185  0.408
2014 Scharfman HE, MacLusky NJ. Sex differences in the neurobiology of epilepsy: a preclinical perspective. Neurobiology of Disease. 72: 180-92. PMID 25058745 DOI: 10.1016/j.nbd.2014.07.004  0.396
2014 Scharfman HE, Brooks-Kayal AR. Is plasticity of GABAergic mechanisms relevant to epileptogenesis? Advances in Experimental Medicine and Biology. 813: 133-50. PMID 25012373 DOI: 10.1007/978-94-017-8914-1_11  0.43
2014 Fisher RS, Scharfman HE, deCurtis M. How can we identify ictal and interictal abnormal activity? Advances in Experimental Medicine and Biology. 813: 3-23. PMID 25012363 DOI: 10.1007/978-94-017-8914-1_1  0.41
2014 Yang J, Harte-Hargrove LC, Siao CJ, Marinic T, Clarke R, Ma Q, Jing D, Lafrancois JJ, Bath KG, Mark W, Ballon D, Lee FS, Scharfman HE, Hempstead BL. proBDNF negatively regulates neuronal remodeling, synaptic transmission, and synaptic plasticity in hippocampus. Cell Reports. 7: 796-806. PMID 24746813 DOI: 10.1016/j.celrep.2014.03.040  0.678
2014 Pearce PS, Friedman D, Lafrancois JJ, Iyengar SS, Fenton AA, Maclusky NJ, Scharfman HE. Spike-wave discharges in adult Sprague-Dawley rats and their implications for animal models of temporal lobe epilepsy. Epilepsy & Behavior : E&B. 32: 121-31. PMID 24534480 DOI: 10.1016/J.Yebeh.2014.01.004  0.448
2014 Scharfman HE, MacLusky NJ. Differential regulation of BDNF, synaptic plasticity and sprouting in the hippocampal mossy fiber pathway of male and female rats. Neuropharmacology. 76: 696-708. PMID 23660230 DOI: 10.1016/j.neuropharm.2013.04.029  0.338
2013 Brooks-Kayal AR, Bath KG, Berg AT, Galanopoulou AS, Holmes GL, Jensen FE, Kanner AM, O'Brien TJ, Whittemore VH, Winawer MR, Patel M, Scharfman HE. Authors' response to letter by A. Mazarati. Epilepsia. 54: 2229-30. PMID 24304440 DOI: 10.1111/Epi.12414  0.592
2013 Scharfman HE. Cutting through the complexity: the role of brain-derived neurotrophic factor in post-traumatic epilepsy (Commentary on Gill et al.). The European Journal of Neuroscience. 38: 3552-3. PMID 24289826 DOI: 10.1111/ejn.12419  0.35
2013 Scharfman HE, Chao MV. The entorhinal cortex and neurotrophin signaling in Alzheimer's disease and other disorders. Cognitive Neuroscience. 4: 123-35. PMID 24168199 DOI: 10.1080/17588928.2013.826184  0.356
2013 Brooks-Kayal AR, Bath KG, Berg AT, Galanopoulou AS, Holmes GL, Jensen FE, Kanner AM, O'Brien TJ, Whittemore VH, Winawer MR, Patel M, Scharfman HE. Issues related to symptomatic and disease-modifying treatments affecting cognitive and neuropsychiatric comorbidities of epilepsy. Epilepsia. 54: 44-60. PMID 23909853 DOI: 10.1111/Epi.12298  0.673
2013 Myers CE, Bermudez-Hernandez K, Scharfman HE. The influence of ectopic migration of granule cells into the hilus on dentate gyrus-CA3 function. Plos One. 8: e68208. PMID 23840835 DOI: 10.1371/journal.pone.0068208  0.471
2013 Scharfman HE, Binder DK. Aquaporin-4 water channels and synaptic plasticity in the hippocampus. Neurochemistry International. 63: 702-11. PMID 23684954 DOI: 10.1016/J.Neuint.2013.05.003  0.385
2013 Duffy AM, Schaner MJ, Chin J, Scharfman HE. Expression of c-fos in hilar mossy cells of the dentate gyrus in vivo. Hippocampus. 23: 649-55. PMID 23640815 DOI: 10.1002/Hipo.22138  0.676
2013 Skucas VA, Duffy AM, Harte-Hargrove LC, Magagna-Poveda A, Radman T, Chakraborty G, Schroeder CE, MacLusky NJ, Scharfman HE. Testosterone depletion in adult male rats increases mossy fiber transmission, LTP, and sprouting in area CA3 of hippocampus. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 33: 2338-55. PMID 23392664 DOI: 10.1523/Jneurosci.3857-12.2013  0.687
2013 Scharfman HE. Preface to the special issue entitled "The future of translational epilepsy research". Epilepsy & Behavior : E&B. 26: 209. PMID 23352321 DOI: 10.1016/j.yebeh.2012.12.016  0.306
2013 Chin J, Scharfman HE. Shared cognitive and behavioral impairments in epilepsy and Alzheimer's disease and potential underlying mechanisms. Epilepsy & Behavior : E&B. 26: 343-51. PMID 23321057 DOI: 10.1016/j.yebeh.2012.11.040  0.393
2013 Bath KG, Scharfman HE. Impact of early life exposure to antiepileptic drugs on neurobehavioral outcomes based on laboratory animal and clinical research. Epilepsy & Behavior : E&B. 26: 427-39. PMID 23305780 DOI: 10.1016/j.yebeh.2012.10.031  0.63
2013 Harte-Hargrove LC, Maclusky NJ, Scharfman HE. Brain-derived neurotrophic factor-estrogen interactions in the hippocampal mossy fiber pathway: implications for normal brain function and disease. Neuroscience. 239: 46-66. PMID 23276673 DOI: 10.1016/j.neuroscience.2012.12.029  0.352
2013 Scharfman HE, Kramár EA, Luine V, Srivastava DP. Introduction to 'steroid hormone actions in the CNS: the role of brain-derived neurotrophic factor (BDNF)'. Neuroscience. 239: 1-2. PMID 23164677 DOI: 10.1016/J.Neuroscience.2012.10.022  0.321
2012 Scharfman HE, Myers CE. Hilar mossy cells of the dentate gyrus: a historical perspective. Frontiers in Neural Circuits. 6: 106. PMID 23420672 DOI: 10.3389/fncir.2012.00106  0.364
2012 Scharfman HE. "Untangling" Alzheimer's disease and epilepsy. Epilepsy Currents / American Epilepsy Society. 12: 178-83. PMID 23118602 DOI: 10.5698/1535-7511-12.5.178  0.4
2012 Lee H, Dvorak D, Kao HY, Duffy ÁM, Scharfman HE, Fenton AA. Early cognitive experience prevents adult deficits in a neurodevelopmental schizophrenia model. Neuron. 75: 714-24. PMID 22920261 DOI: 10.1016/J.Neuron.2012.06.016  0.613
2012 Scharfman HE. Alzheimer's disease and epilepsy: insight from animal models. Future Neurology. 7: 177-192. PMID 22723738 DOI: 10.2217/fnl.12.8  0.364
2012 Scharfman HE, Pierce JP. New insights into the role of hilar ectopic granule cells in the dentate gyrus based on quantitative anatomic analysis and three-dimensional reconstruction. Epilepsia. 53: 109-15. PMID 22612815 DOI: 10.1111/J.1528-1167.2012.03480.X  0.447
2012 Chakraborty G, Magagna-Poveda A, Parratt C, Umans JG, MacLusky NJ, Scharfman HE. Reduced hippocampal brain-derived neurotrophic factor (BDNF) in neonatal rats after prenatal exposure to propylthiouracil (PTU). Endocrinology. 153: 1311-6. PMID 22253429 DOI: 10.1210/en.2011-1437  0.308
2011 McCloskey DP, Scharfman HE. Progressive, potassium-sensitive epileptiform activity in hippocampal area CA3 of pilocarpine-treated rats with recurrent seizures. Epilepsy Research. 97: 92-102. PMID 21880468 DOI: 10.1016/j.eplepsyres.2011.07.008  0.77
2011 Skucas VA, Mathews IB, Yang J, Cheng Q, Treister A, Duffy AM, Verkman AS, Hempstead BL, Wood MA, Binder DK, Scharfman HE. Impairment of select forms of spatial memory and neurotrophin-dependent synaptic plasticity by deletion of glial aquaporin-4. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 31: 6392-7. PMID 21525279 DOI: 10.1523/Jneurosci.6249-10.2011  0.659
2011 Duffy AM, Schaner MJ, Wu SH, Staniszewski A, Kumar A, Arévalo JC, Arancio O, Chao MV, Scharfman HE. A selective role for ARMS/Kidins220 scaffold protein in spatial memory and trophic support of entorhinal and frontal cortical neurons. Experimental Neurology. 229: 409-20. PMID 21419124 DOI: 10.1016/J.Expneurol.2011.03.008  0.663
2011 Pierce JP, McCloskey DP, Scharfman HE. Morphometry of hilar ectopic granule cells in the rat. The Journal of Comparative Neurology. 519: 1196-218. PMID 21344409 DOI: 10.1002/Cne.22568  0.752
2011 Barouk S, Hintz T, Li P, Duffy AM, MacLusky NJ, Scharfman HE. 17β-estradiol increases astrocytic vascular endothelial growth factor (VEGF) in adult female rat hippocampus. Endocrinology. 152: 1745-51. PMID 21343256 DOI: 10.1210/En.2010-1290  0.64
2011 Myers CE, Scharfman HE. Pattern separation in the dentate gyrus: a role for the CA3 backprojection. Hippocampus. 21: 1190-215. PMID 20683841 DOI: 10.1002/hipo.20828  0.33
2010 McNamara JO, Scharfman HE. Temporal lobe epilepsy and the BDNF receptor, TrkB Epilepsia. 51: 46. DOI: 10.1111/j.1528-1167.2010.02832.x  0.404
2009 Scharfman HE, Malthankar-Phatak GH, Friedman D, Pearce P, McCloskey DP, Harden CL, Maclusky NJ. A rat model of epilepsy in women: a tool to study physiological interactions between endocrine systems and seizures. Endocrinology. 150: 4437-42. PMID 19443573 DOI: 10.1210/en.2009-0135  0.742
2009 Scharfman HE, McCloskey DP. Postnatal neurogenesis as a therapeutic target in temporal lobe epilepsy. Epilepsy Research. 85: 150-61. PMID 19369038 DOI: 10.1016/j.eplepsyres.2009.03.006  0.767
2009 Myers CE, Scharfman HE. A role for hilar cells in pattern separation in the dentate gyrus: a computational approach. Hippocampus. 19: 321-37. PMID 18958849 DOI: 10.1002/hipo.20516  0.345
2008 Scharfman HE, Kim M, Hintz TM, MacLusky NJ. Seizures and reproductive function: insights from female rats with epilepsy. Annals of Neurology. 64: 687-97. PMID 19107990 DOI: 10.1002/ana.21518  0.412
2008 Scharfman HE, MacLusky NJ. Estrogen-growth factor interactions and their contributions to neurological disorders. Headache. 48: S77-89. PMID 18700946 DOI: 10.1111/j.1526-4610.2008.01200.x  0.324
2008 McCloskey DP, Hintz TM, Scharfman HE. Modulation of vascular endothelial growth factor (VEGF) expression in motor neurons and its electrophysiological effects. Brain Research Bulletin. 76: 36-44. PMID 18395608 DOI: 10.1016/j.brainresbull.2007.11.018  0.697
2008 Nicoletti JN, Shah SK, McCloskey DP, Goodman JH, Elkady A, Atassi H, Hylton D, Rudge JS, Scharfman HE, Croll SD. Vascular endothelial growth factor is up-regulated after status epilepticus and protects against seizure-induced neuronal loss in hippocampus. Neuroscience. 151: 232-41. PMID 18065154 DOI: 10.1016/J.Neuroscience.2007.09.083  0.778
2008 Macbeth AH, Scharfman HE, Maclusky NJ, Gautreaux C, Luine VN. Effects of multiparity on recognition memory, monoaminergic neurotransmitters, and brain-derived neurotrophic factor (BDNF). Hormones and Behavior. 54: 7-17. PMID 17927990 DOI: 10.1016/j.yhbeh.2007.08.011  0.303
2007 Scharfman HE, Hintz TM, Gomez J, Stormes KA, Barouk S, Malthankar-Phatak GH, McCloskey DP, Luine VN, Maclusky NJ. Changes in hippocampal function of ovariectomized rats after sequential low doses of estradiol to simulate the preovulatory estrogen surge. The European Journal of Neuroscience. 26: 2595-612. PMID 17970745 DOI: 10.1111/j.1460-9568.2007.05848.x  0.713
2007 Winawer MR, Makarenko N, McCloskey DP, Hintz TM, Nair N, Palmer AA, Scharfman HE. Acute and chronic responses to the convulsant pilocarpine in DBA/2J and A/J mice. Neuroscience. 149: 465-75. PMID 17904758 DOI: 10.1016/J.Neuroscience.2007.06.009  0.72
2007 Scharfman HE. The CA3 "backprojection" to the dentate gyrus. Progress in Brain Research. 163: 627-37. PMID 17765742 DOI: 10.1016/S0079-6123(07)63034-9  0.316
2007 Scharfman HE. The neurobiology of epilepsy. Current Neurology and Neuroscience Reports. 7: 348-54. PMID 17618543 DOI: 10.1007/s11910-007-0053-z  0.415
2007 Pierce JP, Punsoni M, McCloskey DP, Scharfman HE. Mossy cell axon synaptic contacts on ectopic granule cells that are born following pilocarpine-induced seizures. Neuroscience Letters. 422: 136-40. PMID 17611032 DOI: 10.1016/J.Neulet.2007.06.016  0.75
2007 Scharfman HE, Gray WP. Relevance of seizure-induced neurogenesis in animal models of epilepsy to the etiology of temporal lobe epilepsy. Epilepsia. 48: 33-41. PMID 17571351 DOI: 10.1111/j.1528-1167.2007.01065.x  0.35
2007 Howell OW, Silva S, Scharfman HE, Sosunov AA, Zaben M, Shtaya A, Shatya A, McKhann G, Herzog H, Laskowski A, Gray WP. Neuropeptide Y is important for basal and seizure-induced precursor cell proliferation in the hippocampus. Neurobiology of Disease. 26: 174-88. PMID 17317195 DOI: 10.1016/J.Nbd.2006.12.014  0.419
2007 Roesch D, Malthankar-Phatak G, Hintz T, McCloskey D, Sandberg K, Maclusky N, Scharfman H. 418: A model of epilepsy during pregnancy in Sprague-Dawley rats American Journal of Obstetrics and Gynecology. 197: S125. DOI: 10.1016/J.Ajog.2007.10.436  0.688
2007 Scharfman HE, Pedley TA. Temporal Lobe Epilepsy Neurobiology of Disease. 349-369. DOI: 10.1016/B978-012088592-3/50035-9  0.42
2006 Scharfman H, Goodman J, McCloskey D. Ectopic granule cells of the rat dentate gyrus Developmental Neuroscience. 29: 14-27. PMID 17148946 DOI: 10.1159/000096208  0.769
2006 Scharfman HE, MacLusky NJ. Estrogen and brain-derived neurotrophic factor (BDNF) in hippocampus: complexity of steroid hormone-growth factor interactions in the adult CNS. Frontiers in Neuroendocrinology. 27: 415-35. PMID 17055560 DOI: 10.1016/j.yfrne.2006.09.004  0.33
2006 McCloskey DP, Hintz TM, Pierce JP, Scharfman HE. Stereological methods reveal the robust size and stability of ectopic hilar granule cells after pilocarpine-induced status epilepticus in the adult rat. The European Journal of Neuroscience. 24: 2203-10. PMID 17042797 DOI: 10.1111/J.1460-9568.2006.05101.X  0.747
2006 Scharfman HE, Gray WP. Plasticity of neuropeptide Y in the dentate gyrus after seizures, and its relevance to seizure-induced neurogenesis. Exs. 193-211. PMID 16383008  0.342
2005 Pierce JP, Melton J, Punsoni M, McCloskey DP, Scharfman HE. Mossy fibers are the primary source of afferent input to ectopic granule cells that are born after pilocarpine-induced seizures. Experimental Neurology. 196: 316-31. PMID 16342370 DOI: 10.1016/J.Expneurol.2005.08.007  0.739
2005 McCloskey DP, Croll SD, Scharfman HE. Depression of synaptic transmission by vascular endothelial growth factor in adult rat hippocampus and evidence for increased efficacy after chronic seizures. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 25: 8889-97. PMID 16192378 DOI: 10.1523/JNEUROSCI.2577-05.2005  0.758
2005 Scharfman HE. The absence of information about hormones and absence. Epilepsy Currents / American Epilepsy Society. 5: 101-3. PMID 16145615 DOI: 10.1111/j.1535-7511.2005.05309.x  0.313
2005 Scharfman HE, Goodman JH, Rigoulot MA, Berger RE, Walling SG, Mercurio TC, Stormes K, Maclusky NJ. Seizure susceptibility in intact and ovariectomized female rats treated with the convulsant pilocarpine. Experimental Neurology. 196: 73-86. PMID 16084511 DOI: 10.1016/J.Expneurol.2005.07.007  0.605
2005 Wu HQ, Rassoulpour A, Goodman JH, Scharfman HE, Bertram EH, Schwarcz R. Kynurenate and 7-chlorokynurenate formation in chronically epileptic rats. Epilepsia. 46: 1010-6. PMID 16026552 DOI: 10.1111/j.1528-1167.2005.67404.x  0.616
2005 Howell OW, Doyle K, Goodman JH, Scharfman HE, Herzog H, Pringle A, Beck-Sickinger AG, Gray WP. Neuropeptide Y stimulates neuronal precursor proliferation in the post-natal and adult dentate gyrus. Journal of Neurochemistry. 93: 560-70. PMID 15836615 DOI: 10.1111/J.1471-4159.2005.03057.X  0.592
2005 Scharfman H, Goodman J, Macleod A, Phani S, Antonelli C, Croll S. Increased neurogenesis and the ectopic granule cells after intrahippocampal BDNF infusion in adult rats. Experimental Neurology. 192: 348-56. PMID 15755552 DOI: 10.1016/J.Expneurol.2004.11.016  0.609
2004 Scharfman HE. Functional implications of seizure-induced neurogenesis. Advances in Experimental Medicine and Biology. 548: 192-212. PMID 15250595  0.36
2004 Croll SD, Goodman JH, Scharfman HE. Vascular endothelial growth factor (VEGF) in seizures: a double-edged sword. Advances in Experimental Medicine and Biology. 548: 57-68. PMID 15250585 DOI: 10.1007/978-1-4757-6376-8_4  0.615
2003 Scharfman HE. Insight into Molecular Mechanisms of Catamenial Epilepsy. Epilepsy Currents / American Epilepsy Society. 3: 86-88. PMID 15309068 DOI: 10.1046/j.1535-7597.2003.03305.x  0.324
2003 Scharfman HE, Mercurio TC, Goodman JH, Wilson MA, MacLusky NJ. Hippocampal excitability increases during the estrous cycle in the rat: a potential role for brain-derived neurotrophic factor. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 23: 11641-52. PMID 14684866 DOI: 10.1523/Jneurosci.23-37-11641.2003  0.603
2003 Scharfman HE, Sollas AE, Berger RE, Goodman JH, Pierce JP. Perforant path activation of ectopic granule cells that are born after pilocarpine-induced seizures. Neuroscience. 121: 1017-29. PMID 14580952 DOI: 10.1016/S0306-4522(03)00481-0  0.658
2003 Scharfman HE, Sollas AL, Berger RE, Goodman JH. Electrophysiological evidence of monosynaptic excitatory transmission between granule cells after seizure-induced mossy fiber sprouting. Journal of Neurophysiology. 90: 2536-47. PMID 14534276 DOI: 10.1152/Jn.00251.2003  0.624
2002 Scharfman HE. Does the Development of a GABAergic Phenotype by Hippocampal Dentate Gyrus Granule Cells Contribute to Epileptogenesis. Epilepsy Currents / American Epilepsy Society. 2: 63. PMID 15309170 DOI: 10.1046/j.1535-7597.2002.00023.x  0.419
2002 Scharfman HE, Sollas AL, Smith KL, Jackson MB, Goodman JH. Structural and functional asymmetry in the normal and epileptic rat dentate gyrus. The Journal of Comparative Neurology. 454: 424-39. PMID 12455007 DOI: 10.1002/Cne.10449  0.684
2002 Wu HQ, Lee SC, Scharfman HE, Schwarcz R. L-4-chlorokynurenine attenuates kainate-induced seizures and lesions in the rat. Experimental Neurology. 177: 222-32. PMID 12429224 DOI: 10.1006/exnr.2002.7971  0.457
2002 Scharfman HE, Sollas AL, Goodman JH. Spontaneous recurrent seizures after pilocarpine-induced status epilepticus activate calbindin-immunoreactive hilar cells of the rat dentate gyrus. Neuroscience. 111: 71-81. PMID 11955713 DOI: 10.1016/S0306-4522(01)00599-1  0.644
2002 Scharfman HE. Epilepsy as an example of neural plasticity. The Neuroscientist : a Review Journal Bringing Neurobiology, Neurology and Psychiatry. 8: 154-73. PMID 11954560 DOI: 10.1177/107385840200800211  0.436
2002 Scharfman HE, Goodman JH, Sollas AL, Croll SD. Spontaneous limbic seizures after intrahippocampal infusion of brain-derived neurotrophic factor. Experimental Neurology. 174: 201-14. PMID 11922662 DOI: 10.1006/Exnr.2002.7869  0.619
2001 Scharfman HE, Smith KL, Goodman JH, Sollas AL. Survival of dentate hilar mossy cells after pilocarpine-induced seizures and their synchronized burst discharges with area CA3 pyramidal cells. Neuroscience. 104: 741-59. PMID 11440806 DOI: 10.1016/S0306-4522(01)00132-4  0.685
2000 Scharfman HE, Goodman JH, Schwarcz R. Electrophysiological effects of exogenous and endogenous kynurenic acid in the rat brain: studies in vivo and in vitro. Amino Acids. 19: 283-97. PMID 11026500 DOI: 10.1007/s007260070060  0.604
2000 Scharfman HE, Goodman JH, Sollas AL. Granule-like neurons at the hilar/CA3 border after status epilepticus and their synchrony with area CA3 pyramidal cells: functional implications of seizure-induced neurogenesis. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 20: 6144-58. PMID 10934264 DOI: 10.1523/Jneurosci.20-16-06144.2000  0.624
2000 Scharfman HE. Epileptogenesis in the parahippocampal region. Parallels with the dentate gyrus. Annals of the New York Academy of Sciences. 911: 305-27. PMID 10911882  0.359
2000 Wu HQ, Guidetti P, Goodman JH, Varasi M, Ceresoli-Borroni G, Speciale C, Scharfman HE, Schwarcz R. Kynurenergic manipulations influence excitatory synaptic function and excitotoxic vulnerability in the rat hippocampus in vivo. Neuroscience. 97: 243-51. PMID 10799756 DOI: 10.1016/S0306-4522(00)00030-0  0.565
1999 Scharfman HE. The role of nonprincipal cells in dentate gyrus excitability and its relevance to animal models of epilepsy and temporal lobe epilepsy. Advances in Neurology. 79: 805-20. PMID 10514865  0.314
1999 Scharfman HE, Goodman JH, Sollas AL. Actions of brain-derived neurotrophic factor in slices from rats with spontaneous seizures and mossy fiber sprouting in the dentate gyrus. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 19: 5619-31. PMID 10377368 DOI: 10.1523/Jneurosci.19-13-05619.1999  0.649
1998 Scharfman HE, Goodman JH, Du F, Schwarcz R. Chronic changes in synaptic responses of entorhinal and hippocampal neurons after amino-oxyacetic acid (AOAA)-induced entorhinal cortical neuron loss. Journal of Neurophysiology. 80: 3031-46. PMID 9862904 DOI: 10.1152/Jn.1998.80.6.3031  0.626
1998 Scharfman HE, Goodman JH. Effects of central and peripheral administration of kynurenic acid on hippocampal evoked responses in vivo and in vitro. Neuroscience. 86: 751-64. PMID 9692715 DOI: 10.1016/S0306-4522(98)00073-6  0.565
1996 Scharfman HE. Hyperexcitability of entorhinal cortex and hippocampus after application of aminooxyacetic acid (AOAA) to layer III of the rat medial entorhinal cortex in vitro. Journal of Neurophysiology. 76: 2986-3001. PMID 8930249  0.308
1995 Scharfman HE. Electrophysiological diversity of pyramidal-shaped neurons at the granule cell layer/hilus border of the rat dentate gyrus recorded in vitro. Hippocampus. 5: 287-305. PMID 8589793 DOI: 10.1002/hipo.450050403  0.412
1994 Scharfman HE. Synchronization of area CA3 hippocampal pyramidal cells and non-granule cells of the dentate gyrus in bicuculline-treated rat hippocampal slices. Neuroscience. 59: 245-57. PMID 8008190 DOI: 10.1016/0306-4522(94)90593-2  0.307
1993 Kunkel DD, Scharfman HE, Schmiege DL, Schwartzkroin PA. Electron microscopy of intracellularly labeled neurons in the hippocampal slice preparation. Microscopy Research and Technique. 24: 67-84. PMID 7679592 DOI: 10.1002/Jemt.1070240107  0.474
1992 Scharfman HE. Blockade of excitation reveals inhibition of dentate spiny hilar neurons recorded in rat hippocampal slices. Journal of Neurophysiology. 68: 978-84. PMID 1359025  0.323
1990 Scharfman HE, Schwartzkroin PA. Consequences of prolonged afferent stimulation of the rat fascia dentata: epileptiform activity in area CA3 of hippocampus. Neuroscience. 35: 505-17. PMID 2381514 DOI: 10.1016/0306-4522(90)90325-X  0.576
1990 Scharfman HE, Schwartzkroin PA. Responses of cells of the rat fascia dentata to prolonged stimulation of the perforant path: sensitivity of hilar cells and changes in granule cell excitability. Neuroscience. 35: 491-504. PMID 2381513 DOI: 10.1016/0306-4522(90)90324-W  0.571
1990 Scharfman HE, Kunkel DD, Schwartzkroin PA. Synaptic connections of dentate granule cells and hilar neurons: results of paired intracellular recordings and intracellular horseradish peroxidase injections. Neuroscience. 37: 693-707. PMID 2247219 DOI: 10.1016/0306-4522(90)90100-I  0.564
1990 Schwartzkroin PA, Scharfman HE, Sloviter RS. Similarities in circuitry between Ammon's horn and dentate gyrus: local interactions and parallel processing. Progress in Brain Research. 83: 269-86. PMID 1975454 DOI: 10.1016/S0079-6123(08)61256-X  0.552
1989 Scharfman HE, Kunkel DD, Schwartzkroin PA. Intracellular dyes mask immunoreactivity of hippocampal interneurons. Neuroscience Letters. 96: 23-8. PMID 2927710 DOI: 10.1016/0304-3940(89)90237-1  0.541
1989 Scharfman HE, Schwartzkroin PA. Selective depression of GABA-mediated IPSPs by somatostatin in area CA1 of rabbit hippocampal slices. Brain Research. 493: 205-11. PMID 2569913 DOI: 10.1016/0006-8993(89)91155-4  0.539
1989 Scharfman HE, Schwartzkroin PA. Protection of dentate hilar cells from prolonged stimulation by intracellular calcium chelation. Science (New York, N.Y.). 246: 257-60. PMID 2508225 DOI: 10.1126/Science.2508225  0.47
1988 Scharfman HE, Sarvey JM. Physiological correlates of responses to gamma-aminobutyric acid (GABA) recorded from rat visual cortical neurons in vitro. Synapse (New York, N.Y.). 2: 619-26. PMID 3212675 DOI: 10.1002/syn.890020607  0.669
1988 Scharfman HE, Schwartzkroin PA. Further studies of the effects of somatostatin and related peptides in area CA1 of rabbit hippocampus. Cellular and Molecular Neurobiology. 8: 411-29. PMID 2906277 DOI: 10.1007/Bf00711226  0.516
1988 Scharfman HE, Schwartzkroin PA. Electrophysiology of morphologically identified mossy cells of the dentate hilus recorded in guinea pig hippocampal slices. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 8: 3812-21. PMID 2461436 DOI: 10.1523/Jneurosci.08-10-03812.1988  0.567
1987 Scharfman HE, Sarvey JM. Responses to GABA recorded from identified rat visual cortical neurons. Neuroscience. 23: 407-22. PMID 3437972 DOI: 10.1016/0306-4522(87)90065-0  0.654
1985 Scharfman HE, Sarvey JM. Responses to gamma-aminobutyric acid applied to cell bodies and dendrites of rat visual cortical neurons. Brain Research. 358: 385-9. PMID 4075128 DOI: 10.1016/0006-8993(85)90990-4  0.661
1985 Scharfman HE, Sarvey JM. gamma-Aminobutyrate sensitivity does not change during long-term potentiation in rat hippocampal slices. Neuroscience. 15: 695-702. PMID 2999641 DOI: 10.1016/0306-4522(85)90071-5  0.674
1985 Scharfman HE, Sarvey JM. Postsynaptic firing during repetitive stimulation is required for long-term potentiation in hippocampus. Brain Research. 331: 267-74. PMID 2985203 DOI: 10.1016/0006-8993(85)91552-5  0.672
Low-probability matches (unlikely to be authored by this person)
2022 Whitebirch AC, LaFrancois JJ, Jain S, Leary P, Santoro B, Siegelbaum SA, Scharfman HE. Enhanced excitability of the hippocampal CA2 region and its contribution to seizure activity in a mouse model of temporal lobe epilepsy. Neuron. PMID 35987207 DOI: 10.1016/j.neuron.2022.07.020  0.295
1996 Scharfman HE. Conditions required for polysynaptic excitation of dentate granule cells by area CA3 pyramidal cells in rat hippocampal slices. Neuroscience. 72: 655-68. PMID 9157312 DOI: 10.1016/0306-4522(95)00569-2  0.295
1992 Scharfman HE. Differentiation of rat dentate neurons by morphology and electrophysiology in hippocampal slices: granule cells, spiny hilar cells and aspiny 'fast-spiking' cells. Epilepsy Research. Supplement. 7: 93-109. PMID 1361334  0.295
1993 Scharfman HE. Spiny neurons of area CA3c in rat hippocampal slices have similar electrophysiological characteristics and synaptic responses despite morphological variation. Hippocampus. 3: 9-28. PMID 8364685 DOI: 10.1002/hipo.450030103  0.294
2007 Walling SG, Rigoulot MA, Scharfman HE. Acute and chronic changes in glycogen phosphorylase in hippocampus and entorhinal cortex after status epilepticus in the adult male rat. The European Journal of Neuroscience. 26: 178-89. PMID 17614948 DOI: 10.1111/j.1460-9568.2007.05657.x  0.293
1991 Scharfman HE. Dentate hilar cells with dendrites in the molecular layer have lower thresholds for synaptic activation by perforant path than granule cells. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 11: 1660-73. PMID 2045880  0.288
2013 Howell OW, Silva S, Scharfman HE, Sosunov AA, Zaben M, Shtaya A, McKhann G, Herzog H, Laskowski A, Gray WP. Corrigendum to "Neuropeptide Y is important for basal and seizure-induced precursor cell proliferation in the hippocampus" [Neurobiol. Dis. 26/1 (2007) 174-188] Neurobiology of Disease. 49: 199. DOI: 10.1016/J.Nbd.2012.06.006  0.286
1994 Scharfman HE. EPSPs of dentate gyrus granule cells during epileptiform bursts of dentate hilar "mossy" cells and area CA3 pyramidal cells in disinhibited rat hippocampal slices. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 14: 6041-57. PMID 7931561  0.285
1994 Scharfman HE. Evidence from simultaneous intracellular recordings in rat hippocampal slices that area CA3 pyramidal cells innervate dentate hilar mossy cells. Journal of Neurophysiology. 72: 2167-80. PMID 7884451  0.283
1993 Scharfman HE. Activation of dentate hilar neurons by stimulation of the fimbria in rat hippocampal slices. Neuroscience Letters. 156: 61-6. PMID 8105429 DOI: 10.1016/0304-3940(93)90440-V  0.282
2012 Simonato M, Löscher W, Cole AJ, Dudek FE, Engel J, Kaminski RM, Loeb JA, Scharfman H, Staley KJ, Velíšek L, Klitgaard H. Finding a better drug for epilepsy: preclinical screening strategies and experimental trial design. Epilepsia. 53: 1860-7. PMID 22708847 DOI: 10.1111/J.1528-1167.2012.03541.X  0.281
2019 Saadipour K, Tiberi A, Lomardo S, Grajales E, Montroull L, Mañucat-Tan NB, LaFrancois J, Cammer M, Mathews PM, Scharfman HE, Liao FF, Friedman WJ, Zhou XF, Tesco G, Chao MV. Regulation of BACE1 expression after injury is linked to the p75 neurotrophin receptor. Molecular and Cellular Neurosciences. 103395. PMID 31422108 DOI: 10.1016/J.Mcn.2019.103395  0.271
2021 Alcantara-Gonzalez D, Chartampila E, Criscuolo C, Scharfman HE. Early changes in synaptic and intrinsic properties of dentate gyrus granule cells in a mouse model of Alzheimer's disease neuropathology and atypical effects of the cholinergic antagonist atropine. Neurobiology of Disease. 105274. PMID 33484828 DOI: 10.1016/j.nbd.2021.105274  0.271
2006 Scharfman HE, MacLusky NJ. The influence of gonadal hormones on neuronal excitability, seizures, and epilepsy in the female. Epilepsia. 47: 1423-40. PMID 16981857 DOI: 10.1111/j.1528-1167.2006.00672.x  0.27
1995 Scharfman HE. Electrophysiological evidence that dentate hilar mossy cells are excitatory and innervate both granule cells and interneurons. Journal of Neurophysiology. 74: 179-94. PMID 7472322  0.263
2005 Staley K, Scharfman H. A woman's prerogative. Nature Neuroscience. 8: 697-9. PMID 15917829 DOI: 10.1038/nn0605-697  0.253
2001 Binder DK, Croll SD, Gall CM, Scharfman HE. Response: BDNF and epilepsy – the bad could turn out to be good Trends in Neurosciences. 24: 319. DOI: 10.1016/S0166-2236(00)01824-5  0.253
2001 Binder DK, Croll SD, Gall CM, Scharfman HE. BDNF and epilepsy: too much of a good thing? Trends in Neurosciences. 24: 47-53. PMID 11163887 DOI: 10.1016/S0166-2236(00)01682-9  0.252
1990 Scharfman HE. Comparisons of neocortex and hippocampus. Trends in Neurosciences. 13: 365-6. PMID 1699324 DOI: 10.1016/0166-2236(90)90018-6  0.25
1997 Scharfman HE. Hyperexcitability in combined entorhinal/hippocampal slices of adult rat after exposure to brain-derived neurotrophic factor. Journal of Neurophysiology. 78: 1082-95. PMID 9307136  0.246
2010 Kimura A, Hsu M, Seldin M, Verkman AS, Scharfman HE, Binder DK. Protective role of aquaporin-4 water channels after contusion spinal cord injury. Annals of Neurology. 67: 794-801. PMID 20517941 DOI: 10.1002/Ana.22023  0.244
1996 Jackson MB, Scharfman HE. Positive feedback from hilar mossy cells to granule cells in the dentate gyrus revealed by voltage-sensitive dye and microelectrode recording. Journal of Neurophysiology. 76: 601-16. PMID 8836247 DOI: 10.1152/Jn.1996.76.1.601  0.241
2018 Greenwood SG, Montroull L, Volosin M, Scharfman HE, Teng KK, Light M, Torkin R, Maxfield F, Hempstead BL, Friedman WJ. A Novel Neuroprotective Mechanism for Lithium That Prevents Association of the p75NTR-Sortilin Receptor Complex and Attenuates proNGF-Induced Neuronal Death In Vitro and In Vivo. Eneuro. 5. PMID 29349290 DOI: 10.1523/ENEURO.0257-17.2017  0.241
2020 Wilson HA, Creighton C, Scharfman H, Choleris E, MacLusky NJ. Endocrine Insights into the Pathophysiology of Autism Spectrum Disorder. The Neuroscientist : a Review Journal Bringing Neurobiology, Neurology and Psychiatry. 1073858420952046. PMID 32912048 DOI: 10.1177/1073858420952046  0.239
2023 Criscuolo C, Chartampila E, Ginsberg SD, Scharfman HE. Stability of dentate gyrus granule cell mossy fiber BDNF protein expression with age and resistance of granule cells to Alzheimer's disease neuropathology in a mouse model. Biorxiv : the Preprint Server For Biology. PMID 37214931 DOI: 10.1101/2023.05.07.539742  0.237
2001 Reibel S, Depaulis A, Larmet Y, Binder DK, Croll SD, Gall CM, Scharfman HE. BDNF and epilepsy - The bad could turn out to be good [2] (mutiple letters) Trends in Neurosciences. 24: 318-319. PMID 11421232 DOI: 10.1016/S0166-2236(00)01869-5  0.232
2005 Scharfman HE, Maclusky NJ. Similarities between actions of estrogen and BDNF in the hippocampus: coincidence or clue? Trends in Neurosciences. 28: 79-85. PMID 15667930 DOI: 10.1016/j.tins.2004.12.005  0.232
2003 Howell OW, Scharfman HE, Herzog H, Sundstrom LE, Beck-Sickinger A, Gray WP. Neuropeptide Y is neuroproliferative for post-natal hippocampal precursor cells. Journal of Neurochemistry. 86: 646-59. PMID 12859678 DOI: 10.1046/j.1471-4159.2003.01895.x  0.23
2023 Chartampila E, Elayouby KS, Leary P, LaFrancois JJ, Alcantara-Gonzalez D, Jain S, Gerencer K, Botterill JJ, Ginsberg SD, Scharfman HE. Choline supplementation in early life improves and low levels of choline can impair outcomes in a mouse model of Alzheimer's disease. Biorxiv : the Preprint Server For Biology. PMID 37214805 DOI: 10.1101/2023.05.12.540428  0.229
2007 Amaral DG, Scharfman HE, Lavenex P. The dentate gyrus: fundamental neuroanatomical organization (dentate gyrus for dummies). Progress in Brain Research. 163: 3-22. PMID 17765709 DOI: 10.1016/S0079-6123(07)63001-5  0.226
1993 Scharfman HE. Characteristics of spontaneous and evoked EPSPs recorded from dentate spiny hilar cells in rat hippocampal slices. Journal of Neurophysiology. 70: 742-57. PMID 8105038  0.222
1999 Croll SD, Suri C, Compton DL, Simmons MV, Yancopoulos GD, Lindsay RM, Wiegand SJ, Rudge JS, Scharfman HE. Brain-derived neurotrophic factor transgenic mice exhibit passive avoidance deficits, increased seizure severity and in vitro hyperexcitability in the hippocampus and entorhinal cortex. Neuroscience. 93: 1491-506. PMID 10501474 DOI: 10.1016/S0306-4522(99)00296-1  0.216
2004 Binder DK, Scharfman HE. Brain-derived neurotrophic factor. Growth Factors (Chur, Switzerland). 22: 123-31. PMID 15518235 DOI: 10.1080/08977190410001723308  0.216
2010 Schroeder CE, Wilson DA, Radman T, Scharfman H, Lakatos P. Dynamics of Active Sensing and perceptual selection. Current Opinion in Neurobiology. 20: 172-6. PMID 20307966 DOI: 10.1016/J.Conb.2010.02.010  0.211
2012 Lau H, Karantzoulis S, Myers C, Pirraglia E, Li Y, Gurnani A, Glodzik L, Scharfman H, Kesner R, De Leon M, Ferris S. P2-274: Cognitive detection of preclinical Alzheimer's disease Alzheimer's & Dementia. 8: P358-P358. DOI: 10.1016/J.Jalz.2012.05.982  0.207
1994 Scharfman HE. Paradoxical enhancement by bicuculline of dentate granule cell IPSPs evoked by fimbria stimulation in rat hippocampal slices. Neuroscience Letters. 168: 29-33. PMID 8028789 DOI: 10.1016/0304-3940(94)90408-1  0.206
2005 Scharfman HE. Brain-derived neurotrophic factor (BDNF) and the dentate gyrus mossy fibers: Implications for epilepsy Synaptic Plasticity and Transsynaptic Signaling. 201-220. DOI: 10.1007/0-387-25443-9_13  0.203
2020 Scharfman H. Grafts of Encapsulated Fibroblasts Engineered to Release an Anticonvulsant Substance. Epilepsy Currents. 2: 125-126. PMID 15309140 DOI: 10.1046/j.1535-7597.2002.t01-1-00047.x  0.2
2021 Botterill JJ, Vinod KY, Gerencer KJ, Teixeira CM, LaFrancois JJ, Scharfman HE. Bidirectional regulation of cognitive and anxiety-like behaviors by dentate gyrus mossy cells in male and female mice. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. PMID 33472828 DOI: 10.1523/JNEUROSCI.1724-20.2021  0.2
2010 Scharfman HE. Seizing an opportunity: broader definitions of epilepsy may lead to better treatments. Cerebrum : the Dana Forum On Brain Science. 2010: 18. PMID 23447764  0.2
2010 Scharfman HE. Seizing an Opportunity: Broader Definitions of Epilepsy May Lead to Better Treatments. Cerebrum : the Dana Forum On Brain Science. 2010. PMID 21152380  0.2
2005 Scharfman HE. Brain-derived neurotrophic factor and epilepsy--a missing link? Epilepsy Currents / American Epilepsy Society. 5: 83-8. PMID 16145610 DOI: 10.1111/j.1535-7511.2005.05312.x  0.193
2020 Cruz E, Descalzi G, Steinmetz A, Scharfman HE, Katzman A, Alberini CM. CIM6P/IGF-2 Receptor Ligands Reverse Deficits in Angelman Syndrome Model Mice. Autism Research : Official Journal of the International Society For Autism Research. PMID 33108069 DOI: 10.1002/aur.2418  0.19
2002 Scharfman HE. Keeping Pace with Pacemaker Channels. Epilepsy Currents / American Epilepsy Society. 2: 155-156. PMID 15309126 DOI: 10.1046/j.1535-7597.2002.00058.x  0.17
1990 Scharfman HE, Lu SM, Guido W, Adams PR, Sherman SM. N-methyl-D-aspartate receptors contribute to excitatory postsynaptic potentials of cat lateral geniculate neurons recorded in thalamic slices. Proceedings of the National Academy of Sciences of the United States of America. 87: 4548-52. PMID 1972275 DOI: 10.1073/pnas.87.12.4548  0.166
1997 Scharfman HE, Ofer A. Pretreatment with L-kynurenine, the precursor to the excitatory amino acid antagonist kynurenic acid, suppresses epileptiform activity in combined entorhinal/hippocampal slices. Neuroscience Letters. 224: 115-8. PMID 9086470 DOI: 10.1016/S0304-3940(97)13472-3  0.166
2018 Scharfman HE, Galanopoulou AS, French JA, Pitkänen A, Whittemore V, Harte-Hargrove LC. Preclinical common data elements (CDEs) for epilepsy: A joint ILAE/AES and NINDS translational initiative. Epilepsia Open. 3: 9-12. PMID 30450482 DOI: 10.1002/epi4.12235  0.163
1999 Scharfman HE, Hodgkins PS, Lee SC, Schwarcz R. Quantitative differences in the effects of de novo produced and exogenous kynurenic acid in rat brain slices. Neuroscience Letters. 274: 111-4. PMID 10553950 DOI: 10.1016/S0304-3940(99)00690-4  0.161
2021 Botterill JJ, Khlaifia A, Walters BJ, Brimble MA, Scharfman HE, Arruda-Carvalho M. Off-Target Expression of Cre-Dependent Adeno-Associated Viruses in Wild-Type C57BL/6J Mice. Eneuro. PMID 34785571 DOI: 10.1523/ENEURO.0363-21.2021  0.157
2007 Scharfman HE, Hen R. Neuroscience. Is more neurogenesis always better? Science (New York, N.Y.). 315: 336-8. PMID 17234934 DOI: 10.1126/science.1138711  0.154
2018 Harte-Hargrove LC, Galanopoulou AS, French JA, Pitkänen A, Whittemore V, Scharfman HE. Common data elements (CDEs) for preclinical epilepsy research: Introduction to CDEs and description of core CDEs. A TASK3 report of the ILAE/AES joint translational task force. Epilepsia Open. 3: 13-23. PMID 30450483 DOI: 10.1002/epi4.12234  0.148
2018 Gorter JA, van Vliet EA, Dedeurwaerdere S, Buchanan GF, Friedman D, Borges K, Grabenstatter H, Lukasiuk K, Scharfman HE, Nehlig A. A companion to the preclinical common data elements for physiologic data in rodent epilepsy models. A report of the TASK3 Physiology Working Group of the ILAE/AES Joint Translational Task Force. Epilepsia Open. 3: 69-89. PMID 30411072 DOI: 10.1002/epi4.12261  0.14
2023 Criscuolo C, Chartampila E, Ginsberg SD, Scharfman HE. Dentate gyrus granule cells show stability of BDNF protein expression in mossy fiber axons with age and resistance to Alzheimer's disease neuropathology in a mouse model. Eneuro. PMID 38164567 DOI: 10.1523/ENEURO.0192-23.2023  0.12
2000 Scharfman HE, Witter MP, Schwarcz R. The Hippocampal Region: Basic Science and Clinical Implications, Baltimore, Maryland, September 23-26, 1999: Preface Annals of the New York Academy of Sciences. 911: ix-xiii.  0.115
2021 Botterill JJ, Gerencer KJ, Vinod KY, Alcantara-Gonzalez D, Scharfman HE. Dorsal and ventral mossy cells differ in their axonal projections throughout the dentate gyrus of the mouse hippocampus. Hippocampus. PMID 33600026 DOI: 10.1002/hipo.23314  0.113
2023 Borzello M, Ramirez S, Treves A, Lee I, Scharfman H, Stark C, Knierim JJ, Rangel LM. Assessments of dentate gyrus function: discoveries and debates. Nature Reviews. Neuroscience. PMID 37316588 DOI: 10.1038/s41583-023-00710-z  0.111
2000 Scharfman HE, Witter MP, Schwarcz R. The parahippocampal region. Implications for neurological and psychiatric diseases. Introduction. Annals of the New York Academy of Sciences. 911: ix-xiii. PMID 10911863  0.06
2007 Scharfman HE, MacLusky NJ. Response to Hussain and Perucca [3] Epilepsia. 48: 1031-1032. DOI: 10.1111/j.1528-1167.2007.01009_3.x  0.038
2004 Duan Y, Lipkovich I, Ahmed S, Ahl J, Hardy T, Haldane D, Baker R, Tohen M, Liu-Seifert H, Healey K, Kinon BJ, Ahmed S, Lipkovich IA, Tohen MF, Hoffmann V, ... ... Scharfman HE, et al. Abstracts from ASENT 2004 Annual Meeting March 11–13, 2004 Neurorx. 1: 506-514. DOI: 10.1602/Neurorx.1.4.506  0.013
2004 Duan Y, Lipkovich I, Ahmed S, Ahl J, Hardy T, Haldane D, Baker R, Tohen M, Liu-Seifert H, Healey K, Kinon BJ, Ahmed S, Lipkovich IA, Tohen MF, Hoffmann V, ... ... Scharfman HE, et al. Abstracts from ASENT 2004 Annual Meeting March 11–13, 2004 Neurotherapeutics. 1: 506-514. DOI: 10.1007/BF03206636  0.013
2006 Scharfman HE. Special issue Frontiers in Neuroendocrinology. 27: 361-362. DOI: 10.1016/j.yfrne.2006.09.005  0.011
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