David Kaplan - Related publications

SickKids Hospital, Toronto, Toronto, Ontario, Canada 
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50 most relevant papers in past 60 days:
Year Citation  Score
2021 Medrano-González PA, Rivera-Ramírez O, Montaño LF, Rendón-Huerta EP. Proteolytic Processing of CD44 and Its Implications in Cancer. Stem Cells International. 2021: 6667735. PMID 33505471 DOI: 10.1155/2021/6667735   
2021 Lee GE, Lee CJ, An HJ, Kang HC, Lee HS, Lee JY, Oh SR, Cho SJ, Kim DJ, Cho YY. Fargesin Inhibits EGF-Induced Cell Transformation and Colon Cancer Cell Growth by Suppression of CDK2/Cyclin E Signaling Pathway. International Journal of Molecular Sciences. 22. PMID 33669811 DOI: 10.3390/ijms22042073   
2021 Chander Y, Kumar R, Khandelwal N, Singh N, Shringi BN, Barua S, Kumar N. Role of p38 mitogen-activated protein kinase signalling in virus replication and potential for developing broad spectrum antiviral drugs. Reviews in Medical Virology. PMID 33450133 DOI: 10.1002/rmv.2217   
2021 Kim SH, Cho JH, Park BO, Park BC, Kim JH, Park SG, Kim S. Phosphorylation of REPS1 at Ser709 by RSK attenuates the recycling of Transferrin receptor. Bmb Reports. PMID 33407999   
2021 Ho HY, Lin CC, Chuang YC, Lo YS, Hsieh MJ, Chen MK. Apoptotic effects of dehydrocrenatidine via JNK and ERK pathway regulation in oral squamous cell carcinoma. Biomedicine & Pharmacotherapy = Biomedecine & Pharmacotherapie. 137: 111362. PMID 33578238 DOI: 10.1016/j.biopha.2021.111362   
2021 Yi S, Shi W, Zuo M, Wang S, Ma R, Bi H, Cong B, Li Y. Endoplasmic Reticulum Stress Is Involved in Glucocorticoid-Induced Apoptosis in PC12 Cells. Analytical Cellular Pathology (Amsterdam). 2021: 5565671. PMID 33628710 DOI: 10.1155/2021/5565671   
2021 Kobayashi N, Katakura S, Kamimaki C, Somekawa K, Fukuda N, Tanaka K, Watanabe K, Horita N, Hara Y, Piao H, Kaneko T. Resistance mechanisms of epidermal growth factor receptor tyrosine kinase inhibitors in non-small cell lung cancer patients: A meta-analysis. Thoracic Cancer. PMID 33565276 DOI: 10.1111/1759-7714.13878   
2021 Molina E, Hong L, Chefetz I. AMPKα-like proteins as LKB1 downstream targets in cell physiology and cancer. Journal of Molecular Medicine (Berlin, Germany). PMID 33661342 DOI: 10.1007/s00109-021-02040-y   
2021 Jiang T, Wang G, Liu Y, Feng L, Wang M, Liu J, Chen Y, Ouyang L. Development of small-molecule tropomyosin receptor kinase (TRK) inhibitors for fusion cancers. Acta Pharmaceutica Sinica. B. 11: 355-372. PMID 33643817 DOI: 10.1016/j.apsb.2020.05.004   
2021 Liu Y, Yan D, Wang Y, Zhang X, Wang N, Jiao Y, Yan H. Subchronic exposure to acrylamide caused behaviour disorders and related pathological and molecular changes in rat cerebellum. Toxicology Letters. PMID 33421551 DOI: 10.1016/j.toxlet.2021.01.009   
2021 Basolo A, Matrone A, Elisei R, Santini F. Effects of tyrosine kinase inhibitors on thyroid function and thyroid hormone metabolism. Seminars in Cancer Biology. PMID 33476722 DOI: 10.1016/j.semcancer.2020.12.008   
2021 Kuravi S, Cheng J, Fangman G, Polireddy K, McCormick S, Lin TL, Singh AK, Abhyankar S, Ganguly S, Welch DR, Jensen RA, McGuirk JP, Balusu R. Preclinical evaluation of gilteritinib on NPM1-ALK driven Anaplastic Large Cell Lymphoma Cells. Molecular Cancer Research : McR. PMID 33514657 DOI: 10.1158/1541-7786.MCR-20-0738   
2021 Lei B, Tang Q, Sun S, Zhang X, Huang Y, Xu L. Insight into the mechanism of tetrachlorobisphenol A (TCBPA)-induced proliferation of breast cancer cells by GPER-mediated signaling pathways. Environmental Pollution (Barking, Essex : 1987). 275: 116636. PMID 33582643 DOI: 10.1016/j.envpol.2021.116636   
2021 Ha YJ, Choi YS, Oh YR, Kang EH, Khang G, Park YB, Lee YJ. Fucoxanthin Suppresses Osteoclastogenesis via Modulation of MAP Kinase and Nrf2 Signaling. Marine Drugs. 19. PMID 33673704 DOI: 10.3390/md19030132   
2021 Santharam MA, Shukla A, Ihsan AU, Cloutier M, Levesque D, Ramanathan S, Boisvert FM, Ilangumaran S. SILAC proteomics implicates SOCS1 in modulating cellular macromolecular complexes and the ubiquitin conjugating enzyme UBE2D involved in MET receptor tyrosine kinase downregulation. Biochimie. PMID 33493533 DOI: 10.1016/j.biochi.2021.01.012   
2021 Feng PP, Qi YK, Li N, Fei HR. Scutebarbatine A induces cytotoxicity in hepatocellular carcinoma via activation of the MAPK and ER stress signaling pathways. Journal of Biochemical and Molecular Toxicology. e22731. PMID 33512038 DOI: 10.1002/jbt.22731   
2021 Luo Y, Liu Y, Wang C, Gan R. Signaling pathways of EBV-induced oncogenesis. Cancer Cell International. 21: 93. PMID 33549103 DOI: 10.1186/s12935-021-01793-3   
2021 Stanford SM, Collins M, Diaz MA, Holmes ZJ, Gries P, Bliss MR, Lodi A, Zhang V, Tiziani S, Bottini N. The low molecular weight protein tyrosine phosphatase promotes adipogenesis and subcutaneous adipocyte hypertrophy. Journal of Cellular Physiology. PMID 33615467 DOI: 10.1002/jcp.30307   
2021 Kim HJ, Ryu H, Choi HK, Song JY, Hwang SG, Ahn J. Anti-leukemic Activity of AIU2008 in FLT3-ITD-positive Acute Myeloid Leukemia. Anticancer Research. 41: 731-737. PMID 33517277 DOI: 10.21873/anticanres.14824   
2021 Kim HJ, Ryu H, Choi HK, Song JY, Hwang SG, Ahn J. Anti-leukemic Activity of AIU2008 in FLT3-ITD-positive Acute Myeloid Leukemia. Anticancer Research. 41: 731-737. PMID 33517277 DOI: 10.21873/anticanres.14824   
2021 Dehghanian SZ, Pan CT, Lee JM, Shiue YL. ABT-751 Induces Multiple Anticancer Effects in Urinary Bladder Urothelial Carcinoma-Derived Cells: Highlighting the Induction of Cytostasis through the Inhibition of at Both Transcriptional and Post-Translational Levels. International Journal of Molecular Sciences. 22. PMID 33478005 DOI: 10.3390/ijms22020945   
2021 Dhole B, Gupta S, Kumar A. Triiodothyronine stimulates steroid and VEGF production in murine Leydig cells via cAMP-PKA pathway. Andrologia. e13972. PMID 33440041 DOI: 10.1111/and.13972   
2021 Han Z, Zhang Z, Guan Y, Chen B, Yu M, Zhang L, Fang J, Gao Y, Guo Z. New insights into Vitamin C function: Vitamin C induces JAK2 activation through its receptor-like transporter SVCT2. International Journal of Biological Macromolecules. PMID 33484802 DOI: 10.1016/j.ijbiomac.2021.01.120   
2021 Dlugosz P, Teufl M, Schwab M, Kohl KE, Nimpf J. Disabled 1 Is Part of a Signaling Pathway Activated by Epidermal Growth Factor Receptor. International Journal of Molecular Sciences. 22. PMID 33572344 DOI: 10.3390/ijms22041745   
2021 Qin X, Liu Y, Wu Y, Wang S, Wu H, Zhu J. Anti-apoptotic efficacy of Qingnao Yizhi formula in hypoxia/reoxygenation primary cortical neurons through the promotion of synaptic plasticity by modulating the NogoA-Nogo receptor/Rho-Rho kinase signaling pathway. Journal of Traditional Chinese Medicine = Chung I Tsa Chih Ying Wen Pan. 41: 59-67. PMID 33522198 DOI: 10.19852/j.cnki.jtcm.2021.01.008   
2021 Qin X, Liu Y, Wu Y, Wang S, Wu H, Zhu J. Anti-apoptotic efficacy of Qingnao Yizhi formula in hypoxia/reoxygenation primary cortical neurons through the promotion of synaptic plasticity by modulating the NogoA-Nogo receptor/Rho-Rho kinase signaling pathway. Journal of Traditional Chinese Medicine = Chung I Tsa Chih Ying Wen Pan. 41: 59-67. PMID 33522198 DOI: 10.19852/j.cnki.jtcm.2021.01.008   
2021 Fang Y, Yan C, Zhao Q, Xu J, Liu Z, Gao J, Zhu H, Dai Z, Wang D, Tang D. The roles of microbial products in the development of colorectal cancer: a review. Bioengineered. 12: 720-735. PMID 33618627 DOI: 10.1080/21655979.2021.1889109   
2021 Khan H, Singh A, Thapa K, Garg N, Grewal AK, Singh TG. Therapeutic modulation of the Phosphatidylinositol 3-kinases (PI3K) pathway in Cerebral Ischemic Injury. Brain Research. 147399. PMID 33662337 DOI: 10.1016/j.brainres.2021.147399   
2021 Kwon JJ, Hahn WC. A Leucine Rich Repeat Protein Provides a SHOC2 the RAS Circuit: A Structure-Function Perspective. Molecular and Cellular Biology. PMID 33526449 DOI: 10.1128/MCB.00627-20   
2021 Aldaz P, Auzmendi-Iriarte J, Durántez M, Lasheras-Otero I, Carrasco-Garcia E, Zelaya MV, Bragado L, Olías-Arjona A, Egaña L, Samprón N, Morilla I, Redondo-Muñoz M, Rico M, Squatrito M, Maria-Alonso M, et al. Identification of a Dexamethasone Mediated Radioprotection Mechanism Reveals New Therapeutic Vulnerabilities in Glioblastoma. Cancers. 13. PMID 33478100 DOI: 10.3390/cancers13020361   
2021 Ding Y, Jiang Y, Im ST, Myung S, Kim HS, Lee SH. Diphlorethohydroxycarmalol inhibits melanogenesis via protein kinase A/cAMP response element-binding protein and extracellular signal-regulated kinase-mediated microphthalmia-associated transcription factor downregulation in α-melanocyte stimulating hormone-stimulated B16F10 melanoma cells and zebrafish. Cell Biochemistry and Function. PMID 33474761 DOI: 10.1002/cbf.3620   
2021 Beavo JA, Golkowski M, Shimizu-Albergine M, Beltejar MC, Bornfeldt KE, Ong SE. Title: Phosphoproteomic Analysis as an Approach for Understanding Molecular Mechanisms of cAMP-dependent Actions. Molecular Pharmacology. PMID 33574048 DOI: 10.1124/molpharm.120.000197   
2021 Gondkar K, Sathe G, Joshi N, Nair B, Pandey A, Kumar P. Integrated Proteomic and Phosphoproteomics Analysis of DKK3 Signaling Reveals Activated Kinase in the Most Aggressive Gallbladder Cancer. Cells. 10. PMID 33670899 DOI: 10.3390/cells10030511   
2021 Baidya R, Gautheron J, Crawford DHG, Wang H, Bridle KR. Inhibition of MLKL Attenuates Necroptotic Cell Death in a Murine Cell Model of Ischaemia Injury. Journal of Clinical Medicine. 10. PMID 33435617 DOI: 10.3390/jcm10020212   
2021 Zuchman R, Koren R, Horwitz BA. Developmental Roles of the Hog1 Protein Phosphatases of the Maize Pathogen . Journal of Fungi (Basel, Switzerland). 7. PMID 33530602 DOI: 10.3390/jof7020083   
2021 Liu YC, Huang BH, Chung JG, Liu WL, Hsu FT, Lin SS. Lenvatinib Inhibits AKT/NF-κB Signaling and Induces Apoptosis Through Extrinsic/Intrinsic Pathways in Non-small Cell Lung Cancer. Anticancer Research. 41: 123-130. PMID 33419805 DOI: 10.21873/anticanres.14757   
2021 Matsuoka Y, Al-Shareef H, Kogo M, Nakahara H. Effects of decreased Rac activity and malignant state on oral squamous cell carcinoma in vitro. Plos One. 16: e0212323. PMID 33444335 DOI: 10.1371/journal.pone.0212323   
2021 Jung JI, Baek SM, Nguyen TH, Kim JW, Kang CH, Kim S, Imm JY. Effects of Probiotic Culture Supernatant on Cariogenic Biofilm Formation and RANKL-Induced Osteoclastogenesis in RAW 264.7 Macrophages. Molecules (Basel, Switzerland). 26. PMID 33572576 DOI: 10.3390/molecules26030733   
2021 Bi L, Liu Y, Yang Q, Zhou X, Li H, Liu Y, Li J, Lu Y, Tang H. saponin H inhibits the proliferation of glioma cells through the A1 and A3 adenosine receptor‑mediated pathway. International Journal of Molecular Medicine. 47. PMID 33537802 DOI: 10.3892/ijmm.2021.4863   
2021 Dennison L, Mohan AA, Yarchoan M. Tumor and Systemic Immunomodulatory Effects of MEK Inhibition. Current Oncology Reports. 23: 23. PMID 33547983 DOI: 10.1007/s11912-020-01008-4   
2021 Day EK, Zhong Q, Purow B, Lazzara MJ. Data-driven computational modeling identifies determinants of glioblastoma response to SHP2 inhibition. Cancer Research. PMID 33574084 DOI: 10.1158/0008-5472.CAN-20-1756   
2021 Cheng J, Lucas PC, McAllister-Lucas LM. Canonical and Non-Canonical Roles of GRK2 in Lymphocytes. Cells. 10. PMID 33546162 DOI: 10.3390/cells10020307   
2021 Mukherjee R, Vanaja KG, Boyer JA, Gadal S, Solomon H, Chandarlapaty S, Levchenko A, Rosen N. Regulation of PTEN translation by PI3K signaling maintains pathway homeostasis. Molecular Cell. 81: 708-723.e5. PMID 33606974 DOI: 10.1016/j.molcel.2021.01.033   
2021 Liu L, Fu C, Liu Y, Li F. Acetate Stimulates Lipogenesis via AMPKα Signaling in Rabbit Adipose-derived Stem Cells. General and Comparative Endocrinology. 113715. PMID 33444628 DOI: 10.1016/j.ygcen.2021.113715   
2021 Zhang H, Park S, Huang H, Kim E, Yi J, Choi SK, Ryoo Z, Kim M. Anticancer effects and potential mechanisms of ginsenoside Rh2 in various cancer types (Review). Oncology Reports. 45. PMID 33649861 DOI: 10.3892/or.2021.7984   
2021 Bhujbal SP, Keretsu S, Cho SJ. Molecular Modelling Studies on Pyrazole Derivatives for the Design of Potent Rearranged during Transfection Kinase Inhibitors. Molecules (Basel, Switzerland). 26. PMID 33525725 DOI: 10.3390/molecules26030691   
2021 Nikhar S, Siokas I, Schlicher L, Lee S, Gyrd-Hansen M, Degterev A, Cuny GD. Design of pyrido[2,3-d]pyrimidin-7-one inhibitors of receptor interacting protein kinase-2 (RIPK2) and nucleotide-binding oligomerization domain (NOD) cell signaling. European Journal of Medicinal Chemistry. 215: 113252. PMID 33601309 DOI: 10.1016/j.ejmech.2021.113252   
2021 York HM, Patil A, Moorthi UK, Kaur A, Bhowmik A, Hyde GJ, Gandhi H, Fulcher A, Gaus K, Arumugam S. Rapid whole cell imaging reveals a calcium-APPL1-dynein nexus that regulates cohort trafficking of stimulated EGF receptors. Communications Biology. 4: 224. PMID 33597720 DOI: 10.1038/s42003-021-01740-y   
2021 Shao H, Foley DW, Huang S, Abbas AY, Lam F, Gershkovich P, Bradshaw TD, Pepper C, Fischer PM, Wang S. Structure-based design of highly selective 2,4,5-trisubstituted pyrimidine CDK9 inhibitors as anti-cancer agents. European Journal of Medicinal Chemistry. 214: 113244. PMID 33581551 DOI: 10.1016/j.ejmech.2021.113244   
2021 Li X, Palhano Zanela TM, Underbakke ES, Zhao Y. Controlling Kinase Activities by Selective Inhibition of Peptide Substrates. Journal of the American Chemical Society. PMID 33395291 DOI: 10.1021/jacs.0c11566