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Karen Duff, PhD - Publications

Pathology and Cell Biology Columbia University, New York, NY 
Understanding the molecular basis of neurodegenerative and neuropsychiatric diseases.

156 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2022 Chen S, Acosta D, Li L, Liang J, Chang Y, Wang C, Fitzgerald J, Morrison C, Goulbourne CN, Nakano Y, Villegas NCH, Venkataraman L, Brown C, Serrano GE, Bell E, ... ... Duff KE, et al. Wolframin is a novel regulator of tau pathology and neurodegeneration. Acta Neuropathologica. PMID 35389045 DOI: 10.1007/s00401-022-02417-4  0.37
2022 Miranda AM, Ashok A, Chan RB, Zhou B, Xu Y, McIntire LB, Area-Gomez E, Di Paolo G, Duff KE, Oliveira TG, Nuriel T. Effects of APOE4 allelic dosage on lipidomic signatures in the entorhinal cortex of aged mice. Translational Psychiatry. 12: 129. PMID 35351864 DOI: 10.1038/s41398-022-01881-6  0.782
2021 Schaler AW, Runyan AM, Clelland CL, Sydney EJ, Fowler SL, Figueroa HY, Shioda S, Santa-Maria I, Duff KE, Myeku N. PAC1 receptor-mediated clearance of tau in postsynaptic compartments attenuates tau pathology in mouse brain. Science Translational Medicine. 13. PMID 34039738 DOI: 10.1126/scitranslmed.aba7394  0.377
2020 Fung CW, Guo J, Fu H, Figueroa HY, Konofagou EE, Duff KE. Atrophy associated with tau pathology precedes overt cell death in a mouse model of progressive tauopathy. Science Advances. 6. PMID 33067235 DOI: 10.1126/sciadv.abc8098  0.32
2020 Rodriguez GA, Barrett GM, Duff KE, Hussaini SA. Chemogenetic attenuation of neuronal activity in the entorhinal cortex reduces Aβ and tau pathology in the hippocampus. Plos Biology. 18: e3000851. PMID 32822389 DOI: 10.1371/Journal.Pbio.3000851  0.717
2020 Area-Gomez E, Larrea D, Pera M, Agrawal RR, Guilfoyle DN, Pirhaji L, Shannon K, Arain HA, Ashok A, Chen Q, Dillman AA, Figueroa HY, Cookson MR, Gross SS, Fraenkel E, ... Duff KE, et al. APOE4 is Associated with Differential Regional Vulnerability to Bioenergetic Deficits in Aged APOE Mice. Scientific Reports. 10: 4277. PMID 32152337 DOI: 10.1038/S41598-020-61142-8  0.817
2019 Karakatsani ME, Kugelman T, Ji R, Murillo M, Wang S, Niimi Y, Small SA, Duff KE, Konofagou EE. Unilateral Focused Ultrasound-Induced Blood-Brain Barrier Opening Reduces Phosphorylated Tau from The rTg4510 Mouse Model. Theranostics. 9: 5396-5411. PMID 31410223 DOI: 10.7150/Thno.28717  0.379
2019 Fu H, Possenti A, Freer R, Nakano Y, Villegas NCH, Tang M, Cauhy PVM, Lassus BA, Chen S, Fowler SL, Figueroa HY, Huey ED, Johnson GVW, Vendruscolo M, Duff KE. A tau homeostasis signature is linked with the cellular and regional vulnerability of excitatory neurons to tau pathology. Nature Neuroscience. 22: 47-56. PMID 30559469 DOI: 10.1038/S41593-018-0298-7  0.304
2019 Arain HA, Figueroa HY, Area-Gomez E, Duff KE, Nuriel T. P3-175: APOE4 INDUCES REGION-SPECIFIC DYSFUNCTION IN THE ENTORHINAL CORTEX OF AGED APOE4 MICE Alzheimer's & Dementia. 15: P997-P997. DOI: 10.1016/J.Jalz.2019.06.3204  0.726
2018 Fu H, Hardy J, Duff KE. Selective vulnerability in neurodegenerative diseases. Nature Neuroscience. PMID 30250262 DOI: 10.1038/S41593-018-0221-2  0.375
2017 Nuriel T, Peng KY, Ashok A, Dillman AA, Figueroa HY, Apuzzo J, Ambat J, Levy E, Cookson MR, Mathews PM, Duff KE. The Endosomal-Lysosomal Pathway Is Dysregulated by APOE4 Expression in Vivo. Frontiers in Neuroscience. 11: 702. PMID 29311783 DOI: 10.3389/Fnins.2017.00702  0.812
2017 Nuriel T, Angulo SL, Khan U, Ashok A, Chen Q, Figueroa HY, Emrani S, Liu L, Herman M, Barrett G, Savage V, Buitrago L, Cepeda-Prado E, Fung C, Goldberg E, ... ... Duff KE, et al. Neuronal hyperactivity due to loss of inhibitory tone in APOE4 mice lacking Alzheimer's disease-like pathology. Nature Communications. 8: 1464. PMID 29133888 DOI: 10.1038/S41467-017-01444-0  0.812
2017 Kim J, Choi IY, Duff KE, Lee P. Progressive Pathological Changes in Neurochemical Profile of the Hippocampus and Early Changes in the Olfactory Bulbs of Tau Transgenic Mice (rTg4510). Neurochemical Research. PMID 28523532 DOI: 10.1007/S11064-017-2298-5  0.316
2017 Fu H, Rodriguez GA, Herman M, Emrani S, Nahmani E, Barrett G, Figueroa HY, Goldberg E, Hussaini SA, Duff KE. Tau Pathology Induces Excitatory Neuron Loss, Grid Cell Dysfunction, and Spatial Memory Deficits Reminiscent of Early Alzheimer's Disease. Neuron. PMID 28111080 DOI: 10.1016/J.Neuron.2016.12.023  0.694
2017 Nuriel T, Khan U, Angulo S, Ashok A, Gross SS, Hussaini SA, Moreno H, Small SA, Duff KE. APOE4 INDUCES ENTORHINAL CORTEX HYPERMETABOLISM IN THE ABSENCE OF OVERT ALZHEIMER’S DISEASE PATHOLOGY Alzheimer's & Dementia. 13: P204. DOI: 10.1016/J.Jalz.2017.07.070  0.774
2016 Fu H, Hussaini SA, Wegmann S, Profaci C, Daniels JD, Herman M, Emrani S, Figueroa HY, Hyman BT, Davies P, Duff KE. 3D Visualization of the Temporal and Spatial Spread of Tau Pathology Reveals Extensive Sites of Tau Accumulation Associated with Neuronal Loss and Recognition Memory Deficit in Aged Tau Transgenic Mice. Plos One. 11: e0159463. PMID 27466814 DOI: 10.1371/Journal.Pone.0159463  0.371
2016 Wu JW, Hussaini SA, Bastille IM, Rodriguez GA, Mrejeru A, Rilett K, Sanders DW, Cook C, Fu H, Boonen RA, Herman M, Nahmani E, Emrani S, Figueroa YH, Diamond MI, ... ... Duff KE, et al. Neuronal activity enhances tau propagation and tau pathology in vivo. Nature Neuroscience. PMID 27322420 DOI: 10.1038/Nn.4328  0.737
2016 Fá M, Puzzo D, Piacentini R, Staniszewski A, Zhang H, Baltrons MA, Li Puma DD, Chatterjee I, Li J, Saeed F, Berman HL, Ripoli C, Gulisano W, Gonzalez J, Tian H, ... ... Duff KE, et al. Extracellular Tau Oligomers Produce An Immediate Impairment of LTP and Memory. Scientific Reports. 6: 19393. PMID 26786552 DOI: 10.1038/Srep19393  0.568
2015 Myeku N, Clelland CL, Emrani S, Kukushkin NV, Yu WH, Goldberg AL, Duff KE. Tau-driven 26S proteasome impairment and cognitive dysfunction can be prevented early in disease by activating cAMP-PKA signaling. Nature Medicine. PMID 26692334 DOI: 10.1038/nm.4011  0.552
2015 Konofagou E, Chen H, Olumolade O, Duff K. Neurotrophic delivery in Alzheimer’s-model mice Journal of Therapeutic Ultrasound. 3: O18. DOI: 10.1186/2050-5736-3-S1-O18  0.378
2013 Yuan A, Kumar A, Sasaki T, Duff K, Nixon RA. Global axonal transport rates are unaltered in htau mice in vivo. Journal of Alzheimer's Disease : Jad. 37: 579-86. PMID 23948900 DOI: 10.3233/Jad-130671  0.353
2013 Wu J, Dickstein D, Duff K. Mechanism of tau transfer: insights from cell culture and animal models Molecular Neurodegeneration. 8: P50. DOI: 10.1186/1750-1326-8-S1-P50  0.414
2013 Wolozin B, Vanderwyede T, Liu-Yesucevitz L, Dedeoglu A, Petrucelli L, Duff K. P4-034: Viewing neurodegeneration beyond the tangle: The role of RNA binding proteins in Alzheimer's disease Alzheimer's & Dementia. 9: P715-P716. DOI: 10.1016/J.Jalz.2013.05.1422  0.501
2012 Klionsky DJ, Abdalla FC, Abeliovich H, Abraham RT, Acevedo-Arozena A, Adeli K, Agholme L, Agnello M, Agostinis P, Aguirre-Ghiso JA, Ahn HJ, Ait-Mohamed O, Ait-Si-Ali S, Akematsu T, Akira S, ... ... Duff K, et al. Guidelines for the use and interpretation of assays for monitoring autophagy. Autophagy. 8: 445-544. PMID 22966490 DOI: 10.4161/Auto.19496  0.599
2012 Vanderweyde T, Yu H, Varnum M, Liu-Yesucevitz L, Citro A, Ikezu T, Duff K, Wolozin B. Contrasting pathology of the stress granule proteins TIA-1 and G3BP in tauopathies. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 32: 8270-83. PMID 22699908 DOI: 10.1523/Jneurosci.1592-12.2012  0.441
2012 Congdon EE, Wu JW, Myeku N, Figueroa YH, Herman M, Marinec PS, Gestwicki JE, Dickey CA, Yu WH, Duff KE. Methylthioninium chloride (methylene blue) induces autophagy and attenuates tauopathy in vitro and in vivo. Autophagy. 8: 609-22. PMID 22361619 DOI: 10.4161/Auto.19048  0.587
2012 Liu L, Drouet V, Wu JW, Witter MP, Small SA, Clelland C, Duff K. Trans-synaptic spread of tau pathology in vivo. Plos One. 7: e31302. PMID 22312444 DOI: 10.1371/Journal.Pone.0031302  0.434
2012 Chan RB, Oliveira TG, Cortes EP, Honig LS, Duff KE, Small SA, Wenk MR, Shui G, Di Paolo G. Comparative lipidomic analysis of mouse and human brain with Alzheimer disease. The Journal of Biological Chemistry. 287: 2678-88. PMID 22134919 DOI: 10.1074/Jbc.M111.274142  0.354
2012 Myeku N, Yu WH, Duff K. O4-11-03: Interaction between the ubiquitin proteasome system, autophagy and progressive tauopathy in vivo Alzheimer's & Dementia. 8: P636-P637. DOI: 10.1016/J.Jalz.2012.05.1697  0.486
2011 Kim SR, Ries V, Cheng HC, Kareva T, Oo TF, Yu WH, Duff K, Kholodilov N, Burke RE. Age and α-synuclein expression interact to reveal a dependence of dopaminergic axons on endogenous Akt/PKB signaling. Neurobiology of Disease. 44: 215-22. PMID 21782946 DOI: 10.1016/J.Nbd.2011.07.003  0.527
2011 Loane DJ, Washington PM, Vardanian L, Pocivavsek A, Hoe HS, Duff KE, Cernak I, Rebeck GW, Faden AI, Burns MP. Modulation of ABCA1 by an LXR agonist reduces β-amyloid levels and improves outcome after traumatic brain injury. Journal of Neurotrauma. 28: 225-36. PMID 21175399 DOI: 10.1089/Neu.2010.1595  0.769
2011 Yu WH, Liu L, Robin C, Herman M, Figueroa H, Wenk M, Duff K. O4-03-01: Autophagic-lysosomal dysfunction in glucocerebrosidase-associated dementia with lewy bodies Alzheimer's & Dementia. 7: S686-S686. DOI: 10.1016/J.Jalz.2011.05.1980  0.502
2011 Wolozin B, Vanderwyede T, Liu-Yesucevitz L, McKee A, Duff K. O3-05-02: Stress granules and Alzheimer's disease: Colocalization with tau pathology Alzheimer's & Dementia. 7: S507-S507. DOI: 10.1016/J.Jalz.2011.05.1417  0.392
2010 Dall'Armi C, Hurtado-Lorenzo A, Tian H, Morel E, Nezu A, Chan RB, Yu WH, Robinson KS, Yeku O, Small SA, Duff K, Frohman MA, Wenk MR, Yamamoto A, Di Paolo G. The phospholipase D1 pathway modulates macroautophagy. Nature Communications. 1: 142. PMID 21266992 DOI: 10.1038/Ncomms1144  0.532
2010 Oliveira TG, Chan RB, Tian H, Laredo M, Shui G, Staniszewski A, Zhang H, Wang L, Kim TW, Duff KE, Wenk MR, Arancio O, Di Paolo G. Phospholipase d2 ablation ameliorates Alzheimer's disease-linked synaptic dysfunction and cognitive deficits. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 30: 16419-28. PMID 21147981 DOI: 10.1523/Jneurosci.3317-10.2010  0.312
2010 O'Leary JC, Li Q, Marinec P, Blair LJ, Congdon EE, Johnson AG, Jinwal UK, Koren J, Jones JR, Kraft C, Peters M, Abisambra JF, Duff KE, Weeber EJ, Gestwicki JE, et al. Phenothiazine-mediated rescue of cognition in tau transgenic mice requires neuroprotection and reduced soluble tau burden. Molecular Neurodegeneration. 5: 45. PMID 21040568 DOI: 10.1186/1750-1326-5-45  0.342
2010 Netzer WJ, Powell C, Nong Y, Blundell J, Wong L, Duff K, Flajolet M, Greengard P. Lowering beta-amyloid levels rescues learning and memory in a Down syndrome mouse model. Plos One. 5: e10943. PMID 20532168 DOI: 10.1371/Journal.Pone.0010943  0.408
2010 Duff K, Kuret J, Congdon EE. Disaggregation of tau as a therapeutic approach to tauopathies. Current Alzheimer Research. 7: 235-40. PMID 20088807 DOI: 10.2174/156720510791050885  0.354
2010 Wray S, Devine M, Kunath T, Duff K, Morris HR, Houlden H, Rossor MN, Hardy J, Lewis PA. P1-111: Progress towards a neuronal cell model of the tauopathies Alzheimer's & Dementia. 6: S206-S207. DOI: 10.1016/J.Jalz.2010.05.660  0.552
2009 Area-Gomez E, de Groof AJ, Boldogh I, Bird TD, Gibson GE, Koehler CM, Yu WH, Duff KE, Yaffe MP, Pon LA, Schon EA. Presenilins are enriched in endoplasmic reticulum membranes associated with mitochondria. The American Journal of Pathology. 175: 1810-6. PMID 19834068 DOI: 10.2353/Ajpath.2009.090219  0.484
2009 Polydoro M, Acker CM, Duff K, Castillo PE, Davies P. Age-dependent impairment of cognitive and synaptic function in the htau mouse model of tau pathology. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 29: 10741-9. PMID 19710325 DOI: 10.1523/Jneurosci.1065-09.2009  0.367
2009 Yu WH, Dorado B, Figueroa HY, Wang L, Planel E, Cookson MR, Clark LN, Duff KE. Metabolic activity determines efficacy of macroautophagic clearance of pathological oligomeric alpha-synuclein. The American Journal of Pathology. 175: 736-47. PMID 19628769 DOI: 10.2353/Ajpath.2009.080928  0.626
2009 Planel E, Bretteville A, Liu L, Virag L, Du AL, Yu WH, Dickson DW, Whittington RA, Duff KE. Acceleration and persistence of neurofibrillary pathology in a mouse model of tauopathy following anesthesia. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 23: 2595-604. PMID 19279139 DOI: 10.1096/Fj.08-122424  0.583
2009 Kwan AC, Duff K, Gouras GK, Webb WW. Optical visualization of Alzheimer's pathology via multiphoton-excited intrinsic fluorescence and second harmonic generation. Optics Express. 17: 3679-89. PMID 19259208 DOI: 10.1364/Oe.17.003679  0.396
2009 Polydoro M, Acker CM, Duff K, Castillo PE, Davies P. O4-03-01: Age-dependent impairment of cognitive and synaptic function in transgenic mouse model of tau pathology (htau mouse) Alzheimer's & Dementia. 5: P153-P154. DOI: 10.1016/J.Jalz.2009.05.531  0.328
2008 Liu L, Duff K. A technique for serial collection of cerebrospinal fluid from the cisterna magna in mouse. Journal of Visualized Experiments : Jove. PMID 19066529 DOI: 10.3791/960  0.489
2008 Small SA, Duff K. Linking Abeta and tau in late-onset Alzheimer's disease: a dual pathway hypothesis. Neuron. 60: 534-42. PMID 19038212 DOI: 10.1016/J.Neuron.2008.11.007  0.471
2008 Planel E, Krishnamurthy P, Miyasaka T, Liu L, Herman M, Kumar A, Bretteville A, Figueroa HY, Yu WH, Whittington RA, Davies P, Takashima A, Nixon RA, Duff KE. Anesthesia-induced hyperphosphorylation detaches 3-repeat tau from microtubules without affecting their stability in vivo. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 28: 12798-807. PMID 19036972 DOI: 10.1523/Jneurosci.4101-08.2008  0.546
2008 Trojanowski JQ, Duff K, Fillit H, Koroshetz W, Kuret J, Murphy D, Refolo L. New directions for frontotemporal dementia drug discovery. Alzheimer's & Dementia : the Journal of the Alzheimer's Association. 4: 89-93. PMID 18631953 DOI: 10.1016/J.Jalz.2007.06.001  0.312
2008 Liu L, Orozco IJ, Planel E, Wen Y, Bretteville A, Krishnamurthy P, Wang L, Herman M, Figueroa H, Yu WH, Arancio O, Duff K. A transgenic rat that develops Alzheimer's disease-like amyloid pathology, deficits in synaptic plasticity and cognitive impairment. Neurobiology of Disease. 31: 46-57. PMID 18504134 DOI: 10.1016/J.Nbd.2008.03.005  0.604
2008 Hirata-Fukae C, Li HF, Hoe HS, Gray AJ, Minami SS, Hamada K, Niikura T, Hua F, Tsukagoshi-Nagai H, Horikoshi-Sakuraba Y, Mughal M, Rebeck GW, LaFerla FM, Mattson MP, Iwata N, ... ... Duff KE, et al. Females exhibit more extensive amyloid, but not tau, pathology in an Alzheimer transgenic model. Brain Research. 1216: 92-103. PMID 18486110 DOI: 10.1016/J.Brainres.2008.03.079  0.636
2008 Muhammad A, Flores I, Zhang H, Yu R, Staniszewski A, Planel E, Herman M, Ho L, Kreber R, Honig LS, Ganetzky B, Duff K, Arancio O, Small SA. Retromer deficiency observed in Alzheimer's disease causes hippocampal dysfunction, neurodegeneration, and Abeta accumulation. Proceedings of the National Academy of Sciences of the United States of America. 105: 7327-32. PMID 18480253 DOI: 10.1073/Pnas.0802545105  0.487
2008 Wen Y, Yu WH, Maloney B, Bailey J, Ma J, Marié I, Maurin T, Wang L, Figueroa H, Herman M, Krishnamurthy P, Liu L, Planel E, Lau LF, Lahiri DK, ... Duff K, et al. Transcriptional regulation of beta-secretase by p25/cdk5 leads to enhanced amyloidogenic processing. Neuron. 57: 680-90. PMID 18341989 DOI: 10.1016/J.Neuron.2008.02.024  0.598
2008 Wen Y, Planel E, Herman M, Figueroa HY, Wang L, Liu L, Lau LF, Yu WH, Duff KE. Interplay between cyclin-dependent kinase 5 and glycogen synthase kinase 3 beta mediated by neuregulin signaling leads to differential effects on tau phosphorylation and amyloid precursor protein processing. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 28: 2624-32. PMID 18322105 DOI: 10.1523/Jneurosci.5245-07.2008  0.555
2008 Yuan A, Kumar A, Peterhoff C, Duff K, Nixon RA. Axonal transport rates in vivo are unaffected by tau deletion or overexpression in mice. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 28: 1682-7. PMID 18272688 DOI: 10.1523/Jneurosci.5242-07.2008  0.33
2008 Yu WH, Matsuoka Y, Sziráki I, Hashim A, Lafrancois J, Sershen H, Duff KE. Increased dopaminergic neuron sensitivity to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) in transgenic mice expressing mutant A53T alpha-synuclein. Neurochemical Research. 33: 902-11. PMID 17999181 DOI: 10.1007/s11064-007-9533-4  0.468
2008 Small S, Duff K, Arancio O, Ganetzky B, Honig L. O3-01-03: Retromer deficiency observed in Alzheimer's disease causes hippocampal dysfunction, neurodegeneration, and Abeta accumulation Alzheimers & Dementia. 4. DOI: 10.1016/J.Jalz.2008.05.407  0.438
2007 Planel E, Tatebayashi Y, Miyasaka T, Liu L, Wang L, Herman M, Yu WH, Luchsinger JA, Wadzinski B, Duff KE, Takashima A. Insulin dysfunction induces in vivo tau hyperphosphorylation through distinct mechanisms. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 27: 13635-48. PMID 18077675 DOI: 10.1523/Jneurosci.3949-07.2007  0.572
2007 Cole AR, Noble W, van Aalten L, Plattner F, Meimaridou R, Hogan D, Taylor M, LaFrancois J, Gunn-Moore F, Verkhratsky A, Oddo S, LaFerla F, Giese KP, Dineley KT, Duff K, et al. Collapsin response mediator protein-2 hyperphosphorylation is an early event in Alzheimer's disease progression. Journal of Neurochemistry. 103: 1132-44. PMID 17683481 DOI: 10.1111/J.1471-4159.2007.04829.X  0.679
2007 Falangola MF, Dyakin VV, Lee SP, Bogart A, Babb JS, Duff K, Nixon R, Helpern JA. Quantitative MRI reveals aging-associated T2 changes in mouse models of Alzheimer's disease. Nmr in Biomedicine. 20: 343-51. PMID 17451178 DOI: 10.1002/Nbm.1163  0.493
2007 Planel E, Richter KE, Nolan CE, Finley JE, Liu L, Wen Y, Krishnamurthy P, Herman M, Wang L, Schachter JB, Nelson RB, Lau LF, Duff KE. Anesthesia leads to tau hyperphosphorylation through inhibition of phosphatase activity by hypothermia. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 27: 3090-7. PMID 17376970 DOI: 10.1523/Jneurosci.4854-06.2007  0.351
2007 Gray AJ, Sakaguchi G, Shiratori C, Becker AG, LaFrancois J, Aisen PS, Duff K, Matsuoka Y. Antibody against C-terminal Abeta selectively elevates plasma Abeta. Neuroreport. 18: 293-6. PMID 17314674 DOI: 10.1097/Wnr.0B013E3280148E76  0.38
2007 Duff K, Krishnamurthy P, Planel E, Hutton M. Animal models of tauopathy Alzheimer's Disease: Advances in Genetics, Molecular and Cellular Biology. 215-236. DOI: 10.1007/978-0-387-35135-3_13  0.372
2006 Burns MP, Igbavboa U, Wang L, Wood WG, Duff K. Cholesterol distribution, not total levels, correlate with altered amyloid precursor protein processing in statin-treated mice. Neuromolecular Medicine. 8: 319-28. PMID 16775383 DOI: 10.1385/Nmm:8:3:319  0.663
2006 Burns MP, Vardanian L, Pajoohesh-Ganji A, Wang L, Cooper M, Harris DC, Duff K, Rebeck GW. The effects of ABCA1 on cholesterol efflux and Abeta levels in vitro and in vivo. Journal of Neurochemistry. 98: 792-800. PMID 16771834 DOI: 10.1111/J.1471-4159.2006.03925.X  0.744
2006 Bell KF, Ducatenzeiler A, Ribeiro-da-Silva A, Duff K, Bennett DA, Cuello AC. The amyloid pathology progresses in a neurotransmitter-specific manner. Neurobiology of Aging. 27: 1644-57. PMID 16271419 DOI: 10.1016/J.Neurobiolaging.2005.09.034  0.465
2006 Rodriguez GA, Hussaini SA, Duff KE. P1-022: ATTENUATION OF Aβ-ASSOCIATED HYPERACTIVITY IN THE ENTORHINAL CORTEX AMELIORATES HIPPOCAMPAL PLAQUE BURDEN Alzheimer's & Dementia. 14: P273-P273. DOI: 10.1016/J.Jalz.2018.06.023  0.652
2006 Burns MP, Cernak I, Vardanian L, Cruz MI, Cartagena C, Wang L, Duff K, Rebeck GW. O4-01-04: Traumatic brain injury-a model for cholesterol redistribution and A-beta metabolism Alzheimer's & Dementia. 2: S75-S75. DOI: 10.1016/J.Jalz.2006.05.294  0.694
2005 Soreghan BA, Lu BW, Thomas SN, Duff K, Rakhmatulin EA, Nikolskaya T, Chen T, Yang AJ. Using proteomics and network analysis to elucidate the consequences of synaptic protein oxidation in a PS1 + AbetaPP mouse model of Alzheimer's disease. Journal of Alzheimer's Disease : Jad. 8: 227-41. PMID 16340081 DOI: 10.3233/Jad-2005-8302  0.386
2005 Yu WH, Cuervo AM, Kumar A, Peterhoff CM, Schmidt SD, Lee JH, Mohan PS, Mercken M, Farmery MR, Tjernberg LO, Jiang Y, Duff K, Uchiyama Y, Näslund J, Mathews PM, et al. Macroautophagy--a novel Beta-amyloid peptide-generating pathway activated in Alzheimer's disease. The Journal of Cell Biology. 171: 87-98. PMID 16203860 DOI: 10.1083/Jcb.200505082  0.63
2005 Kumar-Singh S, Pirici D, McGowan E, Serneels S, Ceuterick C, Hardy J, Duff K, Dickson D, Van Broeckhoven C. Dense-core plaques in Tg2576 and PSAPP mouse models of Alzheimer's disease are centered on vessel walls. The American Journal of Pathology. 167: 527-43. PMID 16049337 DOI: 10.1016/S0002-9440(10)62995-1  0.712
2005 Matsuoka Y, Shao L, Debnath M, Lafrancois J, Becker A, Gray A, Aisen P, Mathis C, Klunk W, Duff K. An Abeta sequestration approach using non-antibody Abeta binding agents. Current Alzheimer Research. 2: 265-8. PMID 15974928 DOI: 10.2174/1567205053585774  0.387
2005 Andorfer C, Acker CM, Kress Y, Hof PR, Duff K, Davies P. Cell-cycle reentry and cell death in transgenic mice expressing nonmutant human tau isoforms. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 25: 5446-54. PMID 15930395 DOI: 10.1523/Jneurosci.4637-04.2005  0.446
2005 Falangola MF, Lee SP, Nixon RA, Duff K, Helpern JA. Histological co-localization of iron in Abeta plaques of PS/APP transgenic mice. Neurochemical Research. 30: 201-5. PMID 15895823 DOI: 10.1007/S11064-004-2442-X  0.438
2005 Noble W, Planel E, Zehr C, Olm V, Meyerson J, Suleman F, Gaynor K, Wang L, LaFrancois J, Feinstein B, Burns M, Krishnamurthy P, Wen Y, Bhat R, Lewis J, ... ... Duff K, et al. Inhibition of glycogen synthase kinase-3 by lithium correlates with reduced tauopathy and degeneration in vivo. Proceedings of the National Academy of Sciences of the United States of America. 102: 6990-5. PMID 15867159 DOI: 10.1073/Pnas.0500466102  0.746
2005 Falangola MF, Ardekani BA, Lee SP, Babb JS, Bogart A, Dyakin VV, Nixon R, Duff K, Helpern JA. Application of a non-linear image registration algorithm to quantitative analysis of T2 relaxation time in transgenic mouse models of AD pathology. Journal of Neuroscience Methods. 144: 91-7. PMID 15848243 DOI: 10.1016/J.Jneumeth.2004.10.012  0.367
2004 Tsai J, Grutzendler J, Duff K, Gan WB. Fibrillar amyloid deposition leads to local synaptic abnormalities and breakage of neuronal branches. Nature Neuroscience. 7: 1181-3. PMID 15475950 DOI: 10.1038/Nn1335  0.43
2004 Lee SP, Falangola MF, Nixon RA, Duff K, Helpern JA. Visualization of beta-amyloid plaques in a transgenic mouse model of Alzheimer's disease using MR microscopy without contrast reagents. Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine. 52: 538-44. PMID 15334572 DOI: 10.1002/Mrm.20196  0.465
2004 Cataldo AM, Peterhoff CM, Schmidt SD, Terio NB, Duff K, Beard M, Mathews PM, Nixon RA. Presenilin mutations in familial Alzheimer disease and transgenic mouse models accelerate neuronal lysosomal pathology. Journal of Neuropathology and Experimental Neurology. 63: 821-30. PMID 15330337 DOI: 10.1093/Jnen/63.8.821  0.492
2004 Burns MP, Duff K. Brain on steroids resists neurodegeneration. Nature Medicine. 10: 675-6. PMID 15229510 DOI: 10.1038/Nm0704-675  0.643
2004 Kowa H, Sakakura T, Matsuura Y, Wakabayashi T, Mann DM, Duff K, Tsuji S, Hashimoto T, Iwatsubo T. Mostly separate distributions of CLAC- versus Abeta40- or thioflavin S-reactivities in senile plaques reveal two distinct subpopulations of beta-amyloid deposits. The American Journal of Pathology. 165: 273-81. PMID 15215182 DOI: 10.1016/S0002-9440(10)63295-6  0.45
2004 Echeverria V, Ducatenzeiler A, Alhonen L, Janne J, Grant SM, Wandosell F, Muro A, Baralle F, Li H, Duff K, Szyf M, Cuello AC. Rat transgenic models with a phenotype of intracellular Abeta accumulation in hippocampus and cortex. Journal of Alzheimer's Disease : Jad. 6: 209-19. PMID 15201476 DOI: 10.3233/Jad-2004-6301  0.363
2004 Sadowski M, Pankiewicz J, Scholtzova H, Ji Y, Quartermain D, Jensen CH, Duff K, Nixon RA, Gruen RJ, Wisniewski T. Amyloid-beta deposition is associated with decreased hippocampal glucose metabolism and spatial memory impairment in APP/PS1 mice. Journal of Neuropathology and Experimental Neurology. 63: 418-28. PMID 15198121 DOI: 10.1093/Jnen/63.5.418  0.432
2004 Horikoshi Y, Sakaguchi G, Becker AG, Gray AJ, Duff K, Aisen PS, Yamaguchi H, Maeda M, Kinoshita N, Matsuoka Y. Development of Abeta terminal end-specific antibodies and sensitive ELISA for Abeta variant. Biochemical and Biophysical Research Communications. 319: 733-7. PMID 15184044 DOI: 10.1016/J.Bbrc.2004.05.051  0.398
2004 Sadowski M, Pankiewicz J, Scholtzova H, Li YS, Quartermain D, Duff K, Wisniewski T. Links between the pathology of Alzheimer's disease and vascular dementia. Neurochemical Research. 29: 1257-66. PMID 15176482 DOI: 10.1023/B:Nere.0000023612.66691.E6  0.463
2004 Saura CA, Choi SY, Beglopoulos V, Malkani S, Zhang D, Shankaranarayana Rao BS, Chattarji S, Kelleher RJ, Kandel ER, Duff K, Kirkwood A, Shen J. Loss of presenilin function causes impairments of memory and synaptic plasticity followed by age-dependent neurodegeneration. Neuron. 42: 23-36. PMID 15066262 DOI: 10.1016/S0896-6273(04)00182-5  0.348
2004 Helpern JA, Lee SP, Falangola MF, Dyakin VV, Bogart A, Ardekani B, Duff K, Branch C, Wisniewski T, de Leon MJ, Wolf O, O'Shea J, Nixon RA. MRI assessment of neuropathology in a transgenic mouse model of Alzheimer's disease. Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine. 51: 794-8. PMID 15065253 DOI: 10.1002/Mrm.20038  0.502
2004 Klein RL, Lin WL, Dickson DW, Lewis J, Hutton M, Duff K, Meyer EM, King MA. Rapid neurofibrillary tangle formation after localized gene transfer of mutated tau. The American Journal of Pathology. 164: 347-53. PMID 14695347 DOI: 10.1016/S0002-9440(10)63124-0  0.604
2004 Yang D, Kumar A, Peterson J, Peterhoff CM, Duff K, Nixon RA, Jeyathevan R, Martins RN, Cataldo AM. P3-289 Neurodegeneration in a mouse model of Alzheimer's disease (AD): roles of apoptosis and autophagy Neurobiology of Aging. 25. DOI: 10.1016/S0197-4580(04)81439-8  0.439
2004 Andorfer CA, Acker CM, Kress Y, Duff K, Davies P. P2-078 Neurofibrillary tangles and cell death in transgenic mice expressing non-mutant human isoforms of TAU Neurobiology of Aging. 25: S246. DOI: 10.1016/S0197-4580(04)80825-X  0.386
2004 Scholtzova H, Pankiewicz J, Sadowski M, Quartermain D, Jensen CH, Duff K, Nixon RA, Helpern JH, Gruen RJ, Wisniewski T. P2-007 Age-associated behavioral, metabolic, and structural changes in wild-type littermates of Alzheimer's transgenic mice Neurobiology of Aging. 25. DOI: 10.1016/S0197-4580(04)80755-3  0.368
2004 Bell KF, Ribeiro-da-Silva A, Duff K, Cuello AC. P1-258 A sequential and neurotransmitter-specific involvement of dystrophic neurites in the amyloid pathology Neurobiology of Aging. 25: S169. DOI: 10.1016/S0197-4580(04)80571-2  0.393
2004 Nixon RA, Yu WH, Cuervo AM, Cataldo AM, Mathews PM, Yang D, Zheng P, Peterhoff CM, Kumar A, Jiang Y, Peterson J, Schmidt SD, Mohan P, Duff K, Hassinger L, et al. S4-03-04 Autophagy in Alzheimer's disease pathogenesis Neurobiology of Aging. 25: S70-S71. DOI: 10.1016/S0197-4580(04)80240-9  0.577
2004 Duff K, Noble W. S3-01-01 Symposia session Neurobiology of Aging. 25. DOI: 10.1016/S0197-4580(04)80151-9  0.511
2004 Planel E, Sahara N, Tatebayashi Y, Launey T, Ishiguro K, Duff K, Takashima A. O2-05-07 Insulin dysfunction induces abnormal tau hyperphosphorylation through two distinct mechanisms: implications for diabetes and Alzheimer's disease Neurobiology of Aging. 25: S42-S43. DOI: 10.1016/S0197-4580(04)80141-6  0.354
2003 Petanceska SS, DeRosa S, Sharma A, Diaz N, Duff K, Tint SG, Refolo LM, Pappolla M. Changes in apolipoprotein E expression in response to dietary and pharmacological modulation of cholesterol. Journal of Molecular Neuroscience : Mn. 20: 395-406. PMID 14501024 DOI: 10.1385/Jmn:20:3:395  0.432
2003 Wadghiri YZ, Sigurdsson EM, Sadowski M, Elliott JI, Li Y, Scholtzova H, Tang CY, Aguinaldo G, Pappolla M, Duff K, Wisniewski T, Turnbull DH. Detection of Alzheimer's amyloid in transgenic mice using magnetic resonance microimaging. Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine. 50: 293-302. PMID 12876705 DOI: 10.1002/Mrm.10529  0.455
2003 Andorfer C, Kress Y, Espinoza M, de Silva R, Tucker KL, Barde YA, Duff K, Davies P. Hyperphosphorylation and aggregation of tau in mice expressing normal human tau isoforms. Journal of Neurochemistry. 86: 582-90. PMID 12859672 DOI: 10.1046/J.1471-4159.2003.01879.X  0.497
2003 Burns M, Gaynor K, Olm V, Mercken M, LaFrancois J, Wang L, Mathews PM, Noble W, Matsuoka Y, Duff K. Presenilin redistribution associated with aberrant cholesterol transport enhances beta-amyloid production in vivo. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 23: 5645-9. PMID 12843267  0.75
2003 Noble W, Olm V, Takata K, Casey E, Mary O, Meyerson J, Gaynor K, LaFrancois J, Wang L, Kondo T, Davies P, Burns M, Veeranna, Nixon R, Dickson D, ... ... Duff K, et al. Cdk5 is a key factor in tau aggregation and tangle formation in vivo. Neuron. 38: 555-65. PMID 12765608 DOI: 10.1016/S0896-6273(03)00259-9  0.767
2003 Burns M, Duff K. Use of in vivo models to study the role of cholesterol in the etiology of Alzheimer's disease. Neurochemical Research. 28: 979-86. PMID 12737522 DOI: 10.1023/A:1023294820218  0.705
2003 Baslow MH, Suckow RF, Gaynor K, Bhakoo KK, Marks N, Saito M, Saito M, Duff K, Matsuoka Y, Berg MJ. Brain damage results in down-regulation of N-acetylaspartate as a neuronal osmolyte. Neuromolecular Medicine. 3: 95-104. PMID 12728192 DOI: 10.1385/Nmm:3:2:95  0.302
2003 Burns MP, Noble WJ, Olm V, Gaynor K, Casey E, LaFrancois J, Wang L, Duff K. Co-localization of cholesterol, apolipoprotein E and fibrillar Abeta in amyloid plaques. Brain Research. Molecular Brain Research. 110: 119-25. PMID 12573540 DOI: 10.1016/S0169-328X(02)00647-2  0.75
2003 Matsuoka Y, Saito M, LaFrancois J, Saito M, Gaynor K, Olm V, Wang L, Casey E, Lu Y, Shiratori C, Lemere C, Duff K. Novel therapeutic approach for the treatment of Alzheimer's disease by peripheral administration of agents with an affinity to beta-amyloid. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 23: 29-33. PMID 12514198 DOI: 10.1523/Jneurosci.23-01-00029.2003  0.415
2002 Duff K, Noble W, Gaynor K, Matsuoka Y. Organotypic slice cultures from transgenic mice as disease model systems. Journal of Molecular Neuroscience : Mn. 19: 317-20. PMID 12540058 DOI: 10.1385/Jmn:19:3:317  0.638
2002 Burns M, Duff K. Cholesterol in Alzheimer's disease and tauopathy. Annals of the New York Academy of Sciences. 977: 367-75. PMID 12480774 DOI: 10.1111/J.1749-6632.2002.Tb04839.X  0.722
2002 Urbanc B, Cruz L, Le R, Sanders J, Ashe KH, Duff K, Stanley HE, Irizarry MC, Hyman BT. Neurotoxic effects of thioflavin S-positive amyloid deposits in transgenic mice and Alzheimer's disease. Proceedings of the National Academy of Sciences of the United States of America. 99: 13990-5. PMID 12374847 DOI: 10.1073/Pnas.222433299  0.485
2002 Petanceska SS, DeRosa S, Olm V, Diaz N, Sharma A, Thomas-Bryant T, Duff K, Pappolla M, Refolo LM. Statin therapy for Alzheimer's disease: will it work? Journal of Molecular Neuroscience : Mn. 19: 155-61. PMID 12212773 DOI: 10.1007/S12031-002-0026-2  0.467
2002 Lee HJ, Zhang Y, Zhu C, Duff K, Pardridge WM. Imaging brain amyloid of Alzheimer disease in vivo in transgenic mice with an Abeta peptide radiopharmaceutical. Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism. 22: 223-31. PMID 11823720 DOI: 10.1097/00004647-200202000-00010  0.414
2002 Zheng H, Xu H, Uljon SN, Gross R, Hardy K, Gaynor J, Lafrancois J, Simpkins J, Refolo LM, Petanceska S, Wang R, Duff K. Modulation of A(beta) peptides by estrogen in mouse models. Journal of Neurochemistry. 80: 191-6. PMID 11796757 DOI: 10.1046/J.0022-3042.2001.00690.X  0.418
2001 Refolo LM, Pappolla MA, LaFrancois J, Malester B, Schmidt SD, Thomas-Bryant T, Tint GS, Wang R, Mercken M, Petanceska SS, Duff KE. A cholesterol-lowering drug reduces beta-amyloid pathology in a transgenic mouse model of Alzheimer's disease. Neurobiology of Disease. 8: 890-9. PMID 11592856 DOI: 10.1006/nbdi.2001.0422  0.367
2001 Le R, Cruz L, Urbanc B, Knowles RB, Hsiao-Ashe K, Duff K, Irizarry MC, Stanley HE, Hyman BT. Plaque-induced abnormalities in neurite geometry in transgenic models of Alzheimer disease: implications for neural system disruption. Journal of Neuropathology and Experimental Neurology. 60: 753-8. PMID 11487049 DOI: 10.1093/Jnen/60.8.753  0.487
2001 Duff K, Rao MV. Progress in the modeling of neurodegenerative diseases in transgenic mice. Current Opinion in Neurology. 14: 441-7. PMID 11470959 DOI: 10.1097/00019052-200108000-00003  0.418
2001 Matsuoka Y, Vila M, Lincoln S, McCormack A, Picciano M, LaFrancois J, Yu X, Dickson D, Langston WJ, McGowan E, Farrer M, Hardy J, Duff K, Przedborski S, Di Monte DA. Lack of nigral pathology in transgenic mice expressing human alpha-synuclein driven by the tyrosine hydroxylase promoter. Neurobiology of Disease. 8: 535-9. PMID 11442360 DOI: 10.1006/Nbdi.2001.0392  0.688
2001 Hernandez D, Sugaya K, Qu T, McGowan E, Duff K, McKinney M. Survival and plasticity of basal forebrain cholinergic systems in mice transgenic for presenilin-1 and amyloid precursor protein mutant genes. Neuroreport. 12: 1377-84. PMID 11388415 DOI: 10.1097/00001756-200105250-00018  0.643
2001 Matsuoka Y, Picciano M, Malester B, LaFrancois J, Zehr C, Daeschner JM, Olschowka JA, Fonseca MI, O'Banion MK, Tenner AJ, Lemere CA, Duff K. Inflammatory responses to amyloidosis in a transgenic mouse model of Alzheimer's disease. The American Journal of Pathology. 158: 1345-54. PMID 11290552 DOI: 10.1016/S0002-9440(10)64085-0  0.468
2001 Morgan D, Diamond DM, Gottschall PE, Ugen KE, Dickey C, Hardy J, Duff K, Jantzen P, DiCarlo G, Wilcock D, Connor K, Hatcher J, Hope C, Gordon M, Arendash GW. Erratum: correction: Aβ peptide vaccination prevents memory loss in an animal model of Alzheimer's disease Nature. 412: 660-660. DOI: 10.1038/35088102  0.471
2000 Morgan D, Diamond DM, Gottschall PE, Ugen KE, Dickey C, Hardy J, Duff K, Jantzen P, DiCarlo G, Wilcock D, Connor K, Hatcher J, Hope C, Gordon M, Arendash GW. A beta peptide vaccination prevents memory loss in an animal model of Alzheimer's disease. Nature. 408: 982-5. PMID 11140686 DOI: 10.1038/35050116  0.512
2000 Refolo LM, Malester B, LaFrancois J, Bryant-Thomas T, Wang R, Tint GS, Sambamurti K, Duff K, Pappolla MA. Hypercholesterolemia accelerates the Alzheimer's amyloid pathology in a transgenic mouse model. Neurobiology of Disease. 7: 321-31. PMID 10964604 DOI: 10.1006/Nbdi.2000.0304  0.473
2000 Gandy S, Duff K. Post-menopausal estrogen deprivation and Alzheimer's disease. Experimental Gerontology. 35: 503-11. PMID 10959038 DOI: 10.1016/S0531-5565(00)00116-9  0.467
2000 Lewis J, McGowan E, Rockwood J, Melrose H, Nacharaju P, Van Slegtenhorst M, Gwinn-Hardy K, Paul Murphy M, Baker M, Yu X, Duff K, Hardy J, Corral A, Lin WL, Yen SH, et al. Neurofibrillary tangles, amyotrophy and progressive motor disturbance in mice expressing mutant (P301L) tau protein. Nature Genetics. 25: 402-5. PMID 10932182 DOI: 10.1038/78078  0.738
2000 Takeuchi A, Irizarry MC, Duff K, Saido TC, Hsiao Ashe K, Hasegawa M, Mann DM, Hyman BT, Iwatsubo T. Age-related amyloid beta deposition in transgenic mice overexpressing both Alzheimer mutant presenilin 1 and amyloid beta precursor protein Swedish mutant is not associated with global neuronal loss. The American Journal of Pathology. 157: 331-9. PMID 10880403 DOI: 10.1016/S0002-9440(10)64544-0  0.456
2000 Barrow PA, Empson RM, Gladwell SJ, Anderson CM, Killick R, Yu X, Jefferys JG, Duff K. Functional phenotype in transgenic mice expressing mutant human presenilin-1. Neurobiology of Disease. 7: 119-26. PMID 10783295 DOI: 10.1006/Nbdi.1999.0276  0.374
2000 Duff K, Knight H, Refolo LM, Sanders S, Yu X, Picciano M, Malester B, Hutton M, Adamson J, Goedert M, Burki K, Davies P. Characterization of pathology in transgenic mice over-expressing human genomic and cDNA tau transgenes. Neurobiology of Disease. 7: 87-98. PMID 10783293 DOI: 10.1006/Nbdi.1999.0279  0.581
2000 Wiebringhaus T, Wirak D, Altman R, Cahill K, Duff K, Ruhland M, Koenig G, Baumann K. The effect of presenilin on β-amyloid in knock-in mice carrying the human amyloid precursor protein with Swedish and/or London mutation Neurobiology of Aging. 21: 224. DOI: 10.1016/S0197-4580(00)83338-2  0.405
2000 Hu L, Wong TP, Cote SL, Duff K, Cuello CA. Early differential alterations of cholinergic and non-cholinergic cortical presynaptic boutons in transgenic mice displaying amyloid deposition Neurobiology of Aging. 21: 89. DOI: 10.1016/S0197-4580(00)82623-8  0.398
2000 Duff K, Refolo LM, Hutton M, Davies P. Tau pathobiology in transgenic mouse models Neurobiology of Aging. 21: 76. DOI: 10.1016/S0197-4580(00)82565-8  0.566
2000 Refolo LM, Wang R, Tint SG, Sambamurti K, Francois JL, Duff K. Hypercholesterolemia accelerates amyloid pathology in a transgenic mouse model of Alzheimer's amyloidosis Neurobiology of Aging. 21: 125. DOI: 10.1016/S0197-4580(00)82363-5  0.483
2000 Wang R, Uljon SN, Troncoso JC, Duff K. Molecular anatomy of amyloid β-peptides in Alzheimer's disease patient's brain by mass spectrometry Neurobiology of Aging. 21: 155. DOI: 10.1016/S0197-4580(00)82033-3  0.37
2000 Nixon R, Duff K, Matsuoka Y. 26. The pathobiology of tau protein in neurodegenerative diseases Biological Psychiatry. 47: S7. DOI: 10.1016/S0006-3223(00)00292-4  0.387
1999 Wright KL, Morgan DG, Yu X, Goss JR, Salbaum JM, Duff K, Gordon MN. Mice transgenic for a human amyloid precursor protein promoter-lacZ reporter construct. Journal of Molecular Neuroscience : Mn. 13: 111-20. PMID 10691298 DOI: 10.1385/Jmn:13:1-2:111  0.375
1999 Holcomb LA, Gordon MN, Jantzen P, Hsiao K, Duff K, Morgan D. Behavioral changes in transgenic mice expressing both amyloid precursor protein and presenilin-1 mutations: lack of association with amyloid deposits. Behavior Genetics. 29: 177-85. PMID 10547924 DOI: 10.1023/A:1021691918517  0.411
1999 Steiner H, Duff K, Capell A, Romig H, Grim MG, Lincoln S, Hardy J, Yu X, Picciano M, Fechteler K, Citron M, Kopan R, Pesold B, Keck S, Baader M, et al. A loss of function mutation of presenilin-2 interferes with amyloid beta-peptide production and notch signaling. The Journal of Biological Chemistry. 274: 28669-73. PMID 10497236 DOI: 10.1074/Jbc.274.40.28669  0.531
1999 McGowan E, Sanders S, Iwatsubo T, Takeuchi A, Saido T, Zehr C, Yu X, Uljon S, Wang R, Mann D, Dickson D, Duff K. Amyloid phenotype characterization of transgenic mice overexpressing both mutant amyloid precursor protein and mutant presenilin 1 transgenes. Neurobiology of Disease. 6: 231-44. PMID 10448051 DOI: 10.1006/Nbdi.1999.0243  0.647
1999 Grover A, Houlden H, Baker M, Adamson J, Lewis J, Prihar G, Pickering-Brown S, Duff K, Hutton M. 5' splice site mutations in tau associated with the inherited dementia FTDP-17 affect a stem-loop structure that regulates alternative splicing of exon 10. The Journal of Biological Chemistry. 274: 15134-43. PMID 10329720 DOI: 10.1074/Jbc.274.21.15134  0.462
1999 Wong TP, Debeir T, Duff K, Cuello AC. Reorganization of cholinergic terminals in the cerebral cortex and hippocampus in transgenic mice carrying mutated presenilin-1 and amyloid precursor protein transgenes. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 19: 2706-16. PMID 10087083 DOI: 10.1523/Jneurosci.19-07-02706.1999  0.433
1999 Begley JG, Duan W, Chan S, Duff K, Mattson MP. Altered calcium homeostasis and mitochondrial dysfunction in cortical synaptic compartments of presenilin-1 mutant mice. Journal of Neurochemistry. 72: 1030-9. PMID 10037474 DOI: 10.1046/J.1471-4159.1999.0721030.X  0.402
1998 Hardy J, Duff K, Hardy KG, Perez-Tur J, Hutton M. Genetic dissection of Alzheimer's disease and related dementias: amyloid and its relationship to tau. Nature Neuroscience. 1: 355-8. PMID 10196523 DOI: 10.1038/1565  0.789
1998 Mehta ND, Refolo LM, Eckman C, Sanders S, Yager D, Perez-Tur J, Younkin S, Duff K, Hardy J, Hutton M. Increased Abeta42(43) from cell lines expressing presenilin 1 mutations. Annals of Neurology. 43: 256-8. PMID 9485068 DOI: 10.1002/Ana.410430217  0.761
1998 Holcomb L, Gordon MN, McGowan E, Yu X, Benkovic S, Jantzen P, Wright K, Saad I, Mueller R, Morgan D, Sanders S, Zehr C, O'Campo K, Hardy J, Prada CM, ... ... Duff K, et al. Accelerated Alzheimer-type phenotype in transgenic mice carrying both mutant amyloid precursor protein and presenilin 1 transgenes. Nature Medicine. 4: 97-100. PMID 9427614 DOI: 10.1038/Nm0198-097  0.693
1996 Ward RV, Davis JB, Gray CW, Barton AJ, Bresciani LG, Caivano M, Murphy VF, Duff K, Hutton M, Hardy J, Roberts GW, Karran EH. Presenilin-1 is processed into two major cleavage products in neuronal cell lines. Neurodegeneration : a Journal For Neurodegenerative Disorders, Neuroprotection, and Neuroregeneration. 5: 293-8. PMID 9117540 DOI: 10.1006/Neur.1996.0040  0.617
1996 Barton AJ, Crook BW, Karran EH, Brown F, Dewar D, Mann DM, Pearson RC, Graham DI, Hardy J, Hutton M, Duff K, Goate AM, Clark RF, Roberts GW. Alteration in brain presenilin 1 mRNA expression in early onset familial Alzheimer's disease. Neurodegeneration : a Journal For Neurodegenerative Disorders, Neuroprotection, and Neuroregeneration. 5: 213-8. PMID 8910899 DOI: 10.1006/Neur.1996.0029  0.718
1996 Prihar G, Fuldner RA, Perez-Tur J, Lincoln S, Duff K, Crook R, Hardy J, Philips CA, Venter C, Talbot C, Clark RF, Goate A, Li J, Potter H, Karran E, et al. Structure and alternative splicing of the presenilin-2 gene. Neuroreport. 7: 1680-4. PMID 8904781 DOI: 10.1097/00001756-199607080-00031  0.774
1996 Duff K, Eckman C, Zehr C, Yu X, Prada CM, Perez-tur J, Hutton M, Buee L, Harigaya Y, Yager D, Morgan D, Gordon MN, Holcomb L, Refolo L, Zenk B, et al. Increased amyloid-beta42(43) in brains of mice expressing mutant presenilin 1. Nature. 383: 710-3. PMID 8878479 DOI: 10.1038/383710A0  0.764
1996 Hutton M, Busfield F, Wragg M, Crook R, Perez-Tur J, Clark RF, Prihar G, Talbot C, Phillips H, Wright K, Baker M, Lendon C, Duff K, Martinez A, Houlden H, et al. Complete analysis of the presenilin 1 gene in early onset Alzheimer's disease. Neuroreport. 7: 801-5. PMID 8733749  0.749
1996 Folkesson R, Kosciessa U, Duff K, Hardyt J, Lannfelt L, Winblad B. 81 Preparative isolation of intact 650 kb YAC-APP genomic DNA containing the Swedish amyloid precursor protein 670/671 mutation Neurobiology of Aging. 17. DOI: 10.1016/S0197-4580(96)80083-2  0.329
1995 Perez-Tur J, Froelich S, Prihar G, Crook R, Baker M, Duff K, Wragg M, Busfield F, Lendon C, Clark RF. A mutation in Alzheimer's disease destroying a splice acceptor site in the presenilin-1 gene. Neuroreport. 7: 297-301. PMID 8742474  0.598
1995 Duff K, Hardy J. Alzheimer's disease. Mouse model made. Nature. 373: 476-7. PMID 7845455 DOI: 10.1038/373476A0  0.53
1995 Houlden H, Crook R, Duff K, Hutton M, Collinge J, Roques P, Rossor M, Hardy J. Apolipoprotein E alleles but neither apolipoprotein B nor apolipoprotein AI/CIII alleles are associated with late onset, familial Alzheimer's disease. Neuroscience Letters. 188: 202-4. PMID 7609909 DOI: 10.1016/0304-3940(95)11422-S  0.668
1995 Perez-Tur J, Froelich S, Prihar G, Crook R, Baker M, Duff K, Wragg M, Busfield F, Lendon C, Clark RF, Roques P, Fuldner RA, Johnston J, Cowburn R, Forsell C, et al. A mutation in Alzheimer's disease destroying a splice acceptor site in the presenilin-1 gene. Neuroreport. 7: 297-301. DOI: 10.1097/00001756-199512000-00071  0.774
1994 Rempfer R, Crook R, Houlden H, Duff K, Hutton M, Roberts GW, Raghavan R, Perry R, Hardy J. Parkinson's disease, but not Alzheimer's disease, Lewy body variant associated with mutant alleles at cytochrome P450 gene. Lancet. 344: 815. PMID 7916091 DOI: 10.1016/S0140-6736(94)92370-1  0.615
1994 Crook R, Hardy J, Duff K. Single-day apolipoprotein E genotyping. Journal of Neuroscience Methods. 53: 125-7. PMID 7823614 DOI: 10.1016/0165-0270(94)90168-6  0.401
1993 Brown J, Gydesen S, Sorensen SA, Brun A, Duff K, Houlden H, Fidani L, Kullkarni S, Cummings J, Goate A. Exclusion mapping in familial non-specific dementia. Dementia (Basel, Switzerland). 4: 163-6. PMID 8401786 DOI: 10.1159/000107317  0.661
1993 Hardy J, Duff K. Heterogeneity in Alzheimer's disease. Annals of Medicine. 25: 437-40. PMID 8251141 DOI: 10.3109/07853899309147308  0.56
1993 Lannfelt L, Folkesson R, Mohammed AH, Winblad B, Hellgren D, Duff K, Hardy J. Alzheimer's disease: molecular genetics and transgenic animal models. Behavioural Brain Research. 57: 207-13. PMID 8117426 DOI: 10.1016/0166-4328(93)90137-F  0.601
1992 Mullan M, Houlden H, Windelspecht M, Fidani L, Lombardi C, Diaz P, Rossor M, Crook R, Hardy J, Duff K. A locus for familial early-onset Alzheimer's disease on the long arm of chromosome 14, proximal to the alpha 1-antichymotrypsin gene. Nature Genetics. 2: 340-2. PMID 1303291 DOI: 10.1038/Ng1292-340  0.76
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