cached image

Leonard Petrucelli, PhD - Publications

Neuroscience Research Mayo Clinic Jacksonville, Jacksonville, FL, United States 

234 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2024 Seddighi S, Qi YA, Brown AL, Wilkins OG, Bereda C, Belair C, Zhang YJ, Prudencio M, Keuss MJ, Khandeshi A, Pickles S, Kargbo-Hill SE, Hawrot J, Ramos DM, Yuan H, ... ... Petrucelli L, et al. Mis-spliced transcripts generate de novo proteins in TDP-43-related ALS/FTD. Science Translational Medicine. eadg7162. PMID 38277467 DOI: 10.1126/scitranslmed.adg7162  0.659
2024 Marks JD, Ayuso VE, Carlomagno Y, Yue M, Todd TW, Hao Y, Li Z, McEachin ZT, Shantaraman A, Duong DM, Daughrity LM, Jansen-West K, Shao W, Calliari A, Bejarano JG, ... ... Petrucelli L, et al. TMEM106B core deposition associates with TDP-43 pathology and is increased in risk SNP carriers for frontotemporal dementia. Science Translational Medicine. 16: eadf9735. PMID 38232138 DOI: 10.1126/scitranslmed.adf9735  0.615
2023 Li Z, Weller CA, Shah S, Johnson N, Hao Y, Roberts J, Bereda C, Klaisner S, Machado P, Fratta P, Petrucelli L, Prudencio M, Oskarsson B, Staff NP, Dickson DW, et al. ProtPipe: A Multifunctional Data Analysis Pipeline for Proteomics and Peptidomics. Biorxiv : the Preprint Server For Biology. PMID 38168437 DOI: 10.1101/2023.12.12.571327  0.697
2023 Cabrera GT, Meijboom KE, Abdallah A, Tran H, Foster Z, Weiss A, Wightman N, Stock R, Gendron T, Gruntman A, Giampetruzzi A, Petrucelli L, Brown RH, Mueller C. Artificial microRNA suppresses C9ORF72 variants and decreases toxic dipeptide repeat proteins in vivo. Gene Therapy. PMID 37752346 DOI: 10.1038/s41434-023-00418-w  0.328
2023 Pickles S, Zanetti Alepuz D, Koike Y, Yue M, Tong J, Liu P, Zhou Y, Jansen-West K, Daughrity LM, Song Y, DeTure M, Oskarsson B, Graff-Radford NR, Boeve BF, Petersen RC, ... ... Petrucelli L, et al. CRISPR interference to evaluate modifiers of -mediated toxicity in FTD. Frontiers in Cell and Developmental Biology. 11: 1251551. PMID 37614226 DOI: 10.3389/fcell.2023.1251551  0.677
2023 Estades Ayuso V, Pickles S, Todd T, Yue M, Jansen-West K, Song Y, González Bejarano J, Rawlinson B, DeTure M, Graff-Radford NR, Boeve BF, Knopman DS, Petersen RC, Dickson DW, Josephs KA, ... Petrucelli L, et al. TDP-43-regulated cryptic RNAs accumulate in Alzheimer's disease brains. Molecular Neurodegeneration. 18: 57. PMID 37605276 DOI: 10.1186/s13024-023-00646-z  0.604
2023 Koike Y, Pickles S, Ayuso VE, Jansen-West K, Qi YA, Li Z, Daughrity LM, Yue M, Zhang YJ, Cook CN, Dickson DW, Ward M, Petrucelli L, Prudencio M. Correction: TDP-43 and other hnRNPs regulate cryptic exon inclusion of a key ALS/FTD risk gene, UNC13A. Plos Biology. 21: e3002228. PMID 37451236 DOI: 10.1371/journal.pbio.3002228  0.571
2023 Dulski J, Koga S, Prudencio M, Tipton PW, Ali S, Strongosky AJ, Rose JH, Parrales ZA, Dunmore JA, Jansen-West K, Petrucelli L, Dickson DW, Wszolek ZK. Perry syndrome: Novel DCTN1 mutation in a large kindred and first observation of prodromal disease. Parkinsonism & Related Disorders. 112: 105481. PMID 37336025 DOI: 10.1016/j.parkreldis.2023.105481  0.59
2023 Dulski J, Al-Shaikh RH, Prudencio M, Petrucelli L, Sulek A, Bernatowicz K, Sławek J, Wszolek ZK. First families with spinocerebellar ataxia type 7 in Poland. Neurologia I Neurochirurgia Polska. 57: 310-313. PMID 37283503 DOI: 10.5603/PJNNS.a2023.0037  0.554
2023 Abdelhak A, Barba L, Romoli M, Benkert P, Conversi F, D'Anna L, Masvekar RR, Bielekova B, Prudencio M, Petrucelli L, Meschia JF, Erben Y, Furlan R, De Lorenzo R, Mandelli A, et al. Prognostic performance of blood neurofilament light chain protein in hospitalized COVID-19 patients without major central nervous system manifestations: an individual participant data meta-analysis. Journal of Neurology. PMID 37184659 DOI: 10.1007/s00415-023-11768-1  0.564
2023 Trageser KJ, Yang EJ, Smith C, Iban-Arias R, Oguchi T, Sebastian-Valverde M, Iqbal UH, Wu H, Estill M, Al Rahim M, Raval U, Herman FJ, Zhang YJ, Petrucelli L, Pasinetti GM. Inflammasome-Mediated Neuronal-Microglial Crosstalk: a Therapeutic Substrate for the Familial C9orf72 Variant of Frontotemporal Dementia/Amyotrophic Lateral Sclerosis. Molecular Neurobiology. PMID 37010807 DOI: 10.1007/s12035-023-03315-w  0.31
2023 Koike Y, Pickles S, Estades Ayuso V, Jansen-West K, Qi YA, Li Z, Daughrity LM, Yue M, Zhang YJ, Cook CN, Dickson DW, Ward M, Petrucelli L, Prudencio M. TDP-43 and other hnRNPs regulate cryptic exon inclusion of a key ALS/FTD risk gene, UNC13A. Plos Biology. 21: e3002028. PMID 36930682 DOI: 10.1371/journal.pbio.3002028  0.649
2023 Goodman LD, Prudencio M, Kramer NJ, Martinez-Ramirez LF, Srinivasan AR, Lan M, Parisi MJ, Zhu Y, Chew J, Cook CN, Berson A, Gitler AD, Petrucelli L, Bonini NM. Author Correction: Toxic expanded GGGGCC repeat transcription is mediated by the PAF1 complex in C9orf72-associated FTD. Nature Neuroscience. 26: 528. PMID 36810653 DOI: 10.1038/s41593-023-01274-y  0.567
2023 Seddighi S, Qi YA, Brown AL, Wilkins OG, Bereda C, Belair C, Zhang Y, Prudencio M, Keuss MJ, Khandeshi A, Pickles S, Hill SE, Hawrot J, Ramos DM, Yuan H, ... ... Petrucelli L, et al. Mis-spliced transcripts generate proteins in TDP-43-related ALS/FTD. Biorxiv : the Preprint Server For Biology. PMID 36747793 DOI: 10.1101/2023.01.23.525149  0.658
2022 Meijboom KE, Abdallah A, Fordham NP, Nagase H, Rodriguez T, Kraus C, Gendron TF, Krishnan G, Esanov R, Andrade NS, Rybin MJ, Ramic M, Stephens ZD, Edraki A, Blackwood MT, ... ... Petrucelli L, et al. CRISPR/Cas9-mediated excision of ALS/FTD-causing hexanucleotide repeat expansion in C9ORF72 rescues major disease mechanisms in vivo and in vitro. Nature Communications. 13: 6286. PMID 36271076 DOI: 10.1038/s41467-022-33332-7  0.352
2022 Erben Y, Prudencio M, Marquez CP, Jansen-West KR, Heckman MG, White LJ, Dunmore JA, Cook CN, Lilley MT, Qosja N, Song Y, Al Shaikh RH, Daughrity LM, Bartfield JL, Day GS, ... ... Petrucelli L, et al. Neurofilament light chain and vaccination status associate with clinical outcomes in severe COVID-19. Iscience. 105272. PMID 36213006 DOI: 10.1016/j.isci.2022.105272  0.548
2022 Shao W, Todd TW, Wu Y, Jones CY, Tong J, Jansen-West K, Daughrity LM, Park J, Koike Y, Kurti A, Yue M, Castanedes-Casey M, Del Rosso G, Dunmore JA, Zanetti Alepuz D, ... ... Petrucelli L, et al. Two FTD-ALS genes converge on the endosomal pathway to induce TDP-43 pathology and degeneration. Science (New York, N.Y.). 378: 94-99. PMID 36201573 DOI: 10.1126/science.abq7860  0.64
2022 Erben Y, Marquez CP, Prudencio M, Fortich S, Gendron T, Sanghavi D, Hickson L, Li Y, Edwards MA, Ritchie C, Moreno Franco P, Petrucelli L, Meschia JF. Race affects adverse outcomes of Deep Venous Thrombosis, Pulmonary Embolism, and Acute Kidney Injury in COVID-19 Hospitalized Patients. Journal of Vascular Surgery. Venous and Lymphatic Disorders. PMID 36100130 DOI: 10.1016/j.jvsv.2022.05.019  0.513
2022 Pickles S, Gendron TF, Koike Y, Yue M, Song Y, Kachergus JM, Shi J, DeTure M, Thompson EA, Oskarsson B, Graff-Radford NR, Boeve BF, Petersen RC, Wszolek ZK, Josephs KA, ... ... Petrucelli L, et al. Evidence of cerebellar TDP-43 loss of function in FTLD-TDP. Acta Neuropathologica Communications. 10: 107. PMID 35879741 DOI: 10.1186/s40478-022-01408-6  0.634
2022 Krishnan G, Raitcheva D, Bartlett D, Prudencio M, McKenna-Yasek DM, Douthwright C, Oskarsson BE, Ladha S, King OD, Barmada SJ, Miller TM, Bowser R, Watts JK, Petrucelli L, Brown RH, et al. Poly(GR) and poly(GA) in cerebrospinal fluid as potential biomarkers for C9ORF72-ALS/FTD. Nature Communications. 13: 2799. PMID 35589711 DOI: 10.1038/s41467-022-30387-4  0.634
2022 Hanna Al-Shaikh R, Jansen-West KR, Petrucelli L, Wszolek ZK, Prudencio M. Comment on: Polyglutamine-Expanded Ataxin-3: A Target Engagement Marker for Spinocerebellar Ataxia Type 3 in Peripheral Blood. Movement Disorders : Official Journal of the Movement Disorder Society. 37: 1120-1121. PMID 35587620 DOI: 10.1002/mds.29008  0.582
2022 Akiyama T, Koike Y, Petrucelli L, Gitler AD. Cracking the cryptic code in amyotrophic lateral sclerosis and frontotemporal dementia: Towards therapeutic targets and biomarkers. Clinical and Translational Medicine. 12: e818. PMID 35567447 DOI: 10.1002/ctm2.818  0.32
2022 Garcia-Moreno H, Prudencio M, Thomas-Black G, Solanky N, Jansen-West KR, Hanna Al-Shaikh R, Heslegrave A, Zetterberg H, Santana MM, Pereira de Almeida L, Vasconcelos-Ferreira A, Januário C, Infante J, Faber J, Klockgether T, ... ... Petrucelli L, et al. Tau and neurofilament light-chain as fluid biomarkers in spinocerebellar ataxia type 3. European Journal of Neurology. PMID 35478426 DOI: 10.1111/ene.15373  0.548
2022 Jansen-West K, Todd TW, Daughrity LM, Yue M, Tong J, Carlomagno Y, Del Rosso G, Kurti A, Jones CY, Dunmore JA, Castanedes-Casey M, Dickson DW, Wszolek ZK, Fryer JD, Petrucelli L, et al. Plasma PolyQ-ATXN3 Levels Associate With Cerebellar Degeneration and Behavioral Abnormalities in a New AAV-Based SCA3 Mouse Model. Frontiers in Cell and Developmental Biology. 10: 863089. PMID 35386195 DOI: 10.3389/fcell.2022.863089  0.657
2022 Ma XR, Prudencio M, Koike Y, Vatsavayai SC, Kim G, Harbinski F, Briner A, Rodriguez CM, Guo C, Akiyama T, Schmidt HB, Cummings BB, Wyatt DW, Kurylo K, Miller G, ... ... Petrucelli L, et al. TDP-43 represses cryptic exon inclusion in the FTD-ALS gene UNC13A. Nature. PMID 35197626 DOI: 10.1038/s41586-022-04424-7  0.688
2021 Del Rosso G, Carlomagno Y, Todd TW, Jones CY, Prudencio M, Daughrity LM, Yue M, Jansen-West K, Tong J, Shao W, Wu Y, Castanedes-Casey M, Tabassian L, Oskarsson B, Ling K, ... ... Petrucelli L, et al. HDAC6 Interacts With Poly (GA) and Modulates its Accumulation in c9FTD/ALS. Frontiers in Cell and Developmental Biology. 9: 809942. PMID 35096836 DOI: 10.3389/fcell.2021.809942  0.62
2021 Wu Y, Shao W, Todd TW, Tong J, Yue M, Koga S, Castanedes-Casey M, Librero AL, Lee CW, Mackenzie IR, Dickson DW, Zhang YJ, Petrucelli L, Prudencio M. Microglial lysosome dysfunction contributes to white matter pathology and TDP-43 proteinopathy in GRN-associated FTD. Cell Reports. 36: 109581. PMID 34433069 DOI: 10.1016/j.celrep.2021.109581  0.605
2021 Koike Y, Jansen-West KR, Hanna Al-Shaikh R, Carlomagno Y, Song Y, Dunmore JA, LeDoux MS, Friedman JH, Pena AB, Uitti RJ, Zaremba J, van Gerpen JA, Pfeiffer RF, Veerappan V, Aiba I, ... ... Petrucelli L, et al. Urine levels of the polyglutamine ataxin-3 protein are elevated in patients with spinocerebellar ataxia type 3. Parkinsonism & Related Disorders. 89: 151-154. PMID 34303201 DOI: 10.1016/j.parkreldis.2021.07.018  0.624
2021 Prudencio M, Erben Y, Marquez CP, Jansen-West KR, Franco-Mesa C, Heckman MG, White LJ, Dunmore JA, Cook CN, Lilley MT, Song Y, Harlow CF, Oskarsson B, Nicholson KA, Wszolek ZK, ... ... Petrucelli L, et al. Serum neurofilament light protein correlates with unfavorable clinical outcomes in hospitalized patients with COVID-19. Science Translational Medicine. PMID 34131052 DOI: 10.1126/scitranslmed.abi7643  0.591
2021 Melnick M, Gonzales P, LaRocca TJ, Song Y, Wuu J, Benatar M, Oskarsson B, Petrucelli L, Dowell RD, Link CD, Prudencio M. Application of a bioinformatic pipeline to RNA-seq data identifies novel viruslike sequence in human blood. G3 (Bethesda, Md.). PMID 33914880 DOI: 10.1093/g3journal/jkab141  0.584
2021 Erben Y, Franco-Mesa C, Gloviczki P, Stone W, Quinones-Hinojosa A, Meltzer AJ, Lin M, Greenway MRF, Hamid O, Devcic Z, Toskich B, Ritchie C, Lamb CJ, De Martino RR, Siegel J, ... ... Petrucelli L, et al. Deep Venous Thrombosis and Pulmonary Embolism Among Hospitalized Coronavirus Disease 2019 (COVID-19) Positive Patients Predict Higher Mortality, Prolonged Intensive Care Unit and Hospital Stays in A Multi-Site Healthcare System. Journal of Vascular Surgery. Venous and Lymphatic Disorders. PMID 33836287 DOI: 10.1016/j.jvsv.2021.03.009  0.535
2021 Carlomagno Y, Manne S, DeTure M, Prudencio M, Zhang YJ, Hanna Al-Shaikh R, Dunmore JA, Daughrity LM, Song Y, Castanedes-Casey M, Lewis-Tuffin LJ, Nicholson KA, Wszolek ZK, Dickson DW, Fitzpatrick AWP, ... Petrucelli L, et al. The AD tau core spontaneously self-assembles and recruits full-length tau to filaments. Cell Reports. 34: 108843. PMID 33730588 DOI: 10.1016/j.celrep.2021.108843  0.599
2020 Prudencio M, Garcia-Moreno H, Jansen-West KR, Al-Shaikh RH, Gendron TF, Heckman MG, Spiegel MR, Carlomagno Y, Daughrity LM, Song Y, Dunmore JA, Byron N, Oskarsson B, Nicholson KA, Staff NP, ... ... Petrucelli L, et al. Toward allele-specific targeting therapy and pharmacodynamic marker for spinocerebellar ataxia type 3. Science Translational Medicine. 12. PMID 33087504 DOI: 10.1126/scitranslmed.abb7086  0.607
2020 Cook CN, Wu Y, Odeh HM, Gendron TF, Jansen-West K, Del Rosso G, Yue M, Jiang P, Gomes E, Tong J, Daughrity LM, Avendano NM, Castanedes-Casey M, Shao W, Oskarsson B, ... ... Petrucelli L, et al. poly(GR) aggregation induces TDP-43 proteinopathy. Science Translational Medicine. 12. PMID 32878979 DOI: 10.1126/Scitranslmed.Abb3774  0.46
2020 Prudencio M, Humphrey J, Pickles S, Brown AL, Hill SE, Kachergus J, Shi J, Heckman M, Spiegel M, Cook C, Song Y, Yue M, Daughrity L, Carlomagno Y, Jansen-West K, ... ... Petrucelli L, et al. Truncated stathmin-2 is a marker of TDP-43 pathology in frontotemporal dementia. The Journal of Clinical Investigation. PMID 32790644 DOI: 10.1172/Jci139741  0.696
2020 McEachin ZT, Gendron TF, Raj N, García-Murias M, Banerjee A, Purcell RH, Ward PJ, Todd TW, Merritt-Garza ME, Jansen-West K, Hales CM, García-Sobrino T, Quintáns B, Holler CJ, Taylor G, ... ... Petrucelli L, et al. Chimeric Peptide Species Contribute to Divergent Dipeptide Repeat Pathology in c9ALS/FTD and SCA36. Neuron. PMID 32375063 DOI: 10.1016/J.Neuron.2020.04.011  0.389
2020 Todd TW, McEachin ZT, Chew J, Burch AR, Jansen-West K, Tong J, Yue M, Song Y, Castanedes-Casey M, Kurti A, Dunmore JH, Fryer JD, Zhang YJ, San Millan B, Teijeira Bautista S, ... ... Petrucelli L, et al. Hexanucleotide Repeat Expansions in c9FTD/ALS and SCA36 Confer Selective Patterns of Neurodegeneration In Vivo. Cell Reports. 31: 107616. PMID 32375043 DOI: 10.1016/J.Celrep.2020.107616  0.445
2020 Zhu Q, Jiang J, Gendron TF, McAlonis-Downes M, Jiang L, Taylor A, Diaz Garcia S, Ghosh Dastidar S, Rodriguez MJ, King P, Zhang Y, La Spada AR, Xu H, Petrucelli L, Ravits J, et al. Reduced C9ORF72 function exacerbates gain of toxicity from ALS/FTD-causing repeat expansion in C9orf72. Nature Neuroscience. PMID 32284607 DOI: 10.1038/S41593-020-0619-5  0.456
2020 Frew J, Baradaran-Heravi A, Balgi AD, Wu X, Yan TD, Arns S, Shidmoossavee FS, Tan J, Jaquith JB, Jansen-West KR, Lynn FC, Gao FB, Petrucelli L, Feldman HH, Mackenzie IR, et al. Premature termination codon readthrough upregulates progranulin expression and improves lysosomal function in preclinical models of GRN deficiency. Molecular Neurodegeneration. 15: 21. PMID 32178712 DOI: 10.1186/S13024-020-00369-5  0.347
2020 Arakhamia T, Lee CE, Carlomagno Y, Duong DM, Kundinger SR, Wang K, Williams D, DeTure M, Dickson DW, Cook CN, Seyfried NT, Petrucelli L, Fitzpatrick AWP. Posttranslational Modifications Mediate the Structural Diversity of Tauopathy Strains. Cell. PMID 32032505 DOI: 10.1016/J.Cell.2020.01.027  0.309
2020 Jackson JL, Finch NA, Baker MC, Kachergus JM, DeJesus-Hernandez M, Pereira K, Christopher E, Prudencio M, Heckman MG, Thompson EA, Dickson DW, Shah J, Oskarsson B, Petrucelli L, Rademakers R, et al. Elevated methylation levels, reduced expression levels, and frequent contractions in a clinical cohort of C9orf72 expansion carriers. Molecular Neurodegeneration. 15: 7. PMID 32000838 DOI: 10.1186/S13024-020-0359-8  0.664
2020 Cook C, Petrucelli L. Aβ Puts the Alpha in Synuclein. Neuron. 105: 205-206. PMID 31972141 DOI: 10.1016/J.Neuron.2020.01.001  0.4
2020 Vu L, An J, Kovalik T, Gendron T, Petrucelli L, Bowser R. Cross-sectional and longitudinal measures of chitinase proteins in amyotrophic lateral sclerosis and expression of CHI3L1 in activated astrocytes. Journal of Neurology, Neurosurgery, and Psychiatry. PMID 31937582 DOI: 10.1136/Jnnp-2019-321916  0.378
2019 Dickson DW, Baker MC, Jackson JL, DeJesus-Hernandez M, Finch NA, Tian S, Heckman MG, Pottier C, Gendron TF, Murray ME, Ren Y, Reddy JS, Graff-Radford NR, Boeve BF, Petersen RC, ... ... Petrucelli L, et al. Extensive transcriptomic study emphasizes importance of vesicular transport in C9orf72 expansion carriers. Acta Neuropathologica Communications. 7: 150. PMID 31594549 DOI: 10.1186/S40478-019-0797-0  0.406
2019 Chen Q, Boeve BF, Schwarz CG, Reid R, Tosakulwong N, Lesnick TG, Bove J, Brannelly P, Brushaber D, Coppola G, Dheel C, Dickerson BC, Dickinson S, Faber K, Fields J, ... ... Petrucelli L, et al. Tracking white matter degeneration in asymptomatic and symptomatic MAPT mutation carriers. Neurobiology of Aging. 83: 54-62. PMID 31585367 DOI: 10.1016/J.Neurobiolaging.2019.08.011  0.308
2019 Moore S, Alsop E, Lorenzini I, Starr A, Rabichow BE, Mendez E, Levy JL, Burciu C, Reiman R, Chew J, Belzil VV, Dickson D, Robertson J, Staats KA, Ichida JK, ... Petrucelli L, et al. Correction to: ADAR2 mislocalization and widespread RNA editing aberrations in C9orf72-mediated ALS/FTD. Acta Neuropathologica. PMID 31559488 DOI: 10.1007/S00401-019-02076-Y  0.314
2019 Yamada SB, Gendron TF, Niccoli T, Genuth NR, Grosely R, Shi Y, Glaria I, Kramer NJ, Nakayama L, Fang S, Dinger TJI, Thoeng A, Rocha G, Barna M, Puglisi JD, ... ... Petrucelli L, et al. RPS25 is required for efficient RAN translation of C9orf72 and other neurodegenerative disease-associated nucleotide repeats. Nature Neuroscience. PMID 31358992 DOI: 10.1038/S41593-019-0455-7  0.432
2019 Josephs KA, Zhang YJ, Baker M, Rademakers R, Petrucelli L, Dickson DW. C-terminal and full length TDP-43 specie differ according to FTLD-TDP lesion type but not genetic mutation. Acta Neuropathologica Communications. 7: 100. PMID 31266542 DOI: 10.1186/S40478-019-0755-X  0.35
2019 Goodman LD, Prudencio M, Kramer NJ, Martinez-Ramirez LF, Srinivasan AR, Lan M, Parisi MJ, Zhu Y, Chew J, Cook CN, Berson A, Gitler AD, Petrucelli L, Bonini NM. Toxic expanded GGGGCC repeat transcription is mediated by the PAF1 complex in C9orf72-associated FTD. Nature Neuroscience. PMID 31110321 DOI: 10.1038/S41593-019-0396-1  0.648
2019 Ebbert MTW, Jensen TD, Jansen-West K, Sens JP, Reddy JS, Ridge PG, Kauwe JSK, Belzil V, Pregent L, Carrasquillo MM, Keene D, Larson E, Crane P, Asmann YW, Ertekin-Taner N, ... ... Petrucelli L, et al. Systematic analysis of dark and camouflaged genes reveals disease-relevant genes hiding in plain sight. Genome Biology. 20: 97. PMID 31104630 DOI: 10.1186/S13059-019-1707-2  0.306
2019 Goodman LD, Prudencio M, Srinivasan AR, Rifai OM, Lee VM, Petrucelli L, Bonini NM. eIF4B and eIF4H mediate GR production from expanded G4C2 in a Drosophila model for C9orf72-associated ALS. Acta Neuropathologica Communications. 7: 62. PMID 31023341 DOI: 10.1186/S40478-019-0711-9  0.675
2019 Moore S, Alsop E, Lorenzini I, Starr A, Rabichow BE, Mendez E, Levy JL, Burciu C, Reiman R, Chew J, Belzil VV, W Dickson D, Robertson J, Staats KA, Ichida JK, ... Petrucelli L, et al. ADAR2 mislocalization and widespread RNA editing aberrations in C9orf72-mediated ALS/FTD. Acta Neuropathologica. PMID 30945056 DOI: 10.1007/S00401-019-01999-W  0.391
2019 Cook C, Petrucelli L. Genetic Convergence Brings Clarity to the Enigmatic Red Line in ALS. Neuron. 101: 1057-1069. PMID 30897357 DOI: 10.1016/J.Neuron.2019.02.032  0.403
2019 Chung DC, Carlomagno Y, Cook CN, Jansen-West K, Daughrity L, Lewis-Tuffin LJ, Castanedes-Casey M, DeTure M, Dickson DW, Petrucelli L. Tau exhibits unique seeding properties in globular glial tauopathy. Acta Neuropathologica Communications. 7: 36. PMID 30845985 DOI: 10.1186/S40478-019-0691-9  0.369
2019 Wennberg AM, Whitwell JL, Tosakulwong N, Weigand SD, Murray ME, Machulda MM, Petrucelli L, Mielke MM, Jack CR, Knopman DS, Parisi JE, Petersen RC, Dickson DW, Josephs KA. The influence of tau, amyloid, alpha-synuclein, TDP-43, and vascular pathology in clinically normal elderly individuals. Neurobiology of Aging. 77: 26-36. PMID 30776649 DOI: 10.1016/J.Neurobiolaging.2019.01.008  0.318
2019 Chew J, Cook C, Gendron TF, Jansen-West K, Del Rosso G, Daughrity LM, Castanedes-Casey M, Kurti A, Stankowski JN, Disney MD, Rothstein JD, Dickson DW, Fryer JD, Zhang YJ, Petrucelli L. Aberrant deposition of stress granule-resident proteins linked to C9orf72-associated TDP-43 proteinopathy. Molecular Neurodegeneration. 14: 9. PMID 30767771 DOI: 10.1186/S13024-019-0310-Z  0.426
2019 Zhang YJ, Guo L, Gonzales PK, Gendron TF, Wu Y, Jansen-West K, O'Raw AD, Pickles SR, Prudencio M, Carlomagno Y, Gachechiladze MA, Ludwig C, Tian R, Chew J, DeTure M, ... ... Petrucelli L, et al. Heterochromatin anomalies and double-stranded RNA accumulation underlie poly(PR) toxicity. Science (New York, N.Y.). 363. PMID 30765536 DOI: 10.1126/Science.Aav2606  0.673
2019 Pottier C, Ren Y, Perkerson RB, Baker M, Jenkins GD, van Blitterswijk M, DeJesus-Hernandez M, van Rooij JGJ, Murray ME, Christopher E, McDonnell SK, Fogarty Z, Batzler A, Tian S, Vicente CT, ... ... Petrucelli L, et al. Genome-wide analyses as part of the international FTLD-TDP whole-genome sequencing consortium reveals novel disease risk factors and increases support for immune dysfunction in FTLD. Acta Neuropathologica. PMID 30739198 DOI: 10.1007/S00401-019-01962-9  0.336
2019 Carlomagno Y, Chung DC, Yue M, Kurti A, Avendano NM, Castanedes-Casey M, Hinkle KM, Jansen-West K, Daughrity LM, Tong J, Phillips V, Rademakers R, DeTure M, Fryer JD, Dickson DW, ... Petrucelli L, et al. Enhanced phosphorylation of T153 in soluble tau is a defining biochemical feature of the A152T tau risk variant. Acta Neuropathologica Communications. 7: 10. PMID 30674342 DOI: 10.1186/S40478-019-0661-2  0.386
2019 Eftekharzadeh B, Daigle JG, Kapinos LE, Coyne A, Schiantarelli J, Carlomagno Y, Cook C, Miller SJ, Dujardin S, Amaral AS, Grima JC, Bennett RE, Tepper K, DeTure M, Vanderburg CR, ... ... Petrucelli L, et al. Tau Protein Disrupts Nucleocytoplasmic Transport in Alzheimer's Disease. Neuron. 101: 349. PMID 30653936 DOI: 10.1016/J.Neuron.2018.12.031  0.354
2018 Wang ZF, Ursu A, Childs-Disney JL, Guertler R, Yang WY, Bernat V, Rzuczek SG, Fuerst R, Zhang YJ, Gendron TF, Yildirim I, Dwyer BG, Rice JE, Petrucelli L, Disney MD. The Hairpin Form of r(GC) in c9ALS/FTD Is Repeat-Associated Non-ATG Translated and a Target for Bioactive Small Molecules. Cell Chemical Biology. PMID 30503283 DOI: 10.1016/J.Chembiol.2018.10.018  0.341
2018 Jiang L, Ash PEA, Maziuk BF, Ballance HI, Boudeau S, Abdullatif AA, Orlando M, Petrucelli L, Ikezu T, Wolozin B. TIA1 regulates the generation and response to toxic tau oligomers. Acta Neuropathologica. PMID 30465259 DOI: 10.1007/S00401-018-1937-5  0.406
2018 Wennberg AM, Tosakulwong N, Lesnick TG, Murray ME, Whitwell JL, Liesinger AM, Petrucelli L, Boeve BF, Parisi JE, Knopman DS, Petersen RC, Dickson DW, Josephs KA. Association of Apolipoprotein E ε4 With Transactive Response DNA-Binding Protein 43. Jama Neurology. 75: 1347-1354. PMID 30422173 DOI: 10.1001/Jamaneurol.2018.3139  0.325
2018 Zhao N, Liu CC, Van Ingelgom AJ, Linares C, Kurti A, Knight JA, Heckman MG, Diehl NN, Shinohara M, Martens YA, Attrebi ON, Petrucelli L, Fryer JD, Wszolek ZK, Graff-Radford NR, et al. APOE ε2 is associated with increased tau pathology in primary tauopathy. Nature Communications. 9: 4388. PMID 30348994 DOI: 10.1038/S41467-018-06783-0  0.377
2018 Hanna Al Shaikh R, Caulfield T, Strongosky AJ, Matthew M, Jansen-West KR, Prudencio M, Fryer JD, Petrucelli L, Uitti RJ, Wszolek ZK. TRIO gene segregation in a family with cerebellar ataxia. Neurologia I Neurochirurgia Polska. PMID 30279051 DOI: 10.1016/J.Pjnns.2018.09.006  0.604
2018 Gan L, Cookson MR, Petrucelli L, La Spada AR. Converging pathways in neurodegeneration, from genetics to mechanisms. Nature Neuroscience. 21: 1300-1309. PMID 30258237 DOI: 10.1038/S41593-018-0237-7  0.553
2018 Eftekharzadeh B, Daigle JG, Kapinos LE, Coyne A, Schiantarelli J, Carlomagno Y, Cook C, Miller SJ, Dujardin S, Amaral AS, Grima JC, Bennett RE, Tepper K, DeTure M, Vanderburgh CR, ... ... Petrucelli L, et al. Tau Protein Disrupts Nucleocytoplasmic Transport in Alzheimer's Disease. Neuron. 99: 925-940.e7. PMID 30189209 DOI: 10.1016/J.Neuron.2018.07.039  0.385
2018 Ebbert MTW, Farrugia SL, Sens JP, Jansen-West K, Gendron TF, Prudencio M, McLaughlin IJ, Bowman B, Seetin M, DeJesus-Hernandez M, Jackson J, Brown PH, Dickson DW, van Blitterswijk M, Rademakers R, ... Petrucelli L, et al. Long-read sequencing across the C9orf72 'GGGGCC' repeat expansion: implications for clinical use and genetic discovery efforts in human disease. Molecular Neurodegeneration. 13: 46. PMID 30126445 DOI: 10.1186/S13024-018-0274-4  0.615
2018 Kang SS, Ebbert MTW, Baker KE, Cook C, Wang X, Sens JP, Kocher JP, Petrucelli L, Fryer JD. Microglial translational profiling reveals a convergent APOE pathway from aging, amyloid, and tau. The Journal of Experimental Medicine. PMID 30082275 DOI: 10.1084/Jem.20180653  0.333
2018 Sakae N, Bieniek KF, Zhang YJ, Ross K, Gendron TF, Murray ME, Rademakers R, Petrucelli L, Dickson DW. Poly-GR dipeptide repeat polymers correlate with neurodegeneration and Clinicopathological subtypes in C9ORF72-related brain disease. Acta Neuropathologica Communications. 6: 63. PMID 30029693 DOI: 10.1186/S40478-018-0564-7  0.372
2018 Sanchez-Contreras MY, Kouri N, Cook CN, Serie DJ, Heckman MG, Finch NA, Caselli RJ, Uitti RJ, Wszolek ZK, Graff-Radford N, Petrucelli L, Wang LS, Schellenberg GD, Dickson DW, Rademakers R, et al. Replication of progressive supranuclear palsy genome-wide association study identifies SLCO1A2 and DUSP10 as new susceptibility loci. Molecular Neurodegeneration. 13: 37. PMID 29986742 DOI: 10.1186/S13024-018-0267-3  0.301
2018 Mordes DA, Prudencio M, Goodman LD, Klim JR, Moccia R, Limone F, Pietilainen O, Chowdhary K, Dickson DW, Rademakers R, Bonini NM, Petrucelli L, Eggan K. Dipeptide repeat proteins activate a heat shock response found in C9ORF72-ALS/FTLD patients. Acta Neuropathologica Communications. 6: 55. PMID 29973287 DOI: 10.1186/S40478-018-0555-8  0.683
2018 Zhang YJ, Gendron TF, Ebbert MTW, O'Raw AD, Yue M, Jansen-West K, Zhang X, Prudencio M, Chew J, Cook CN, Daughrity LM, Tong J, Song Y, Pickles SR, Castanedes-Casey M, ... ... Petrucelli L, et al. Poly(GR) impairs protein translation and stress granule dynamics in C9orf72-associated frontotemporal dementia and amyotrophic lateral sclerosis. Nature Medicine. PMID 29942091 DOI: 10.1038/S41591-018-0071-1  0.678
2018 Nicholson AM, Zhou X, Perkerson RB, Parsons TM, Chew J, Brooks M, DeJesus-Hernandez M, Finch NA, Matchett BJ, Kurti A, Jansen-West KR, Perkerson E, Daughrity L, Castanedes-Casey M, Rousseau L, ... ... Petrucelli L, et al. Loss of Tmem106b is unable to ameliorate frontotemporal dementia-like phenotypes in an AAV mouse model of C9ORF72-repeat induced toxicity. Acta Neuropathologica Communications. 6: 42. PMID 29855382 DOI: 10.1186/S40478-018-0545-X  0.363
2018 Saldi TK, Gonzales P, Garrido-Lecca A, Dostal V, Roberts CM, Petrucelli L, Link CD. The ortholog of TDP-43 regulates the chromatin localization of the heterochromatin protein 1 homolog, HPL-2. Molecular and Cellular Biology. PMID 29760282 DOI: 10.1128/Mcb.00668-17  0.39
2018 Pottier C, Zhou X, Perkerson RB, Baker M, Jenkins GD, Serie DJ, Ghidoni R, Benussi L, Binetti G, López de Munain A, Zulaica M, Moreno F, Le Ber I, Pasquier F, Hannequin D, ... ... Petrucelli L, et al. Potential genetic modifiers of disease risk and age at onset in patients with frontotemporal lobar degeneration and GRN mutations: a genome-wide association study. The Lancet. Neurology. PMID 29724592 DOI: 10.1016/S1474-4422(18)30126-1  0.483
2018 Pickles S, Petrucelli L. CRISPR expands insight into the mechanisms of ALS and FTD. Nature Reviews. Neurology. PMID 29695800 DOI: 10.1038/S41582-018-0005-Z  0.363
2018 Tabet R, Schaeffer L, Freyermuth F, Jambeau M, Workman M, Lee CZ, Lin CC, Jiang J, Jansen-West K, Abou-Hamdan H, Désaubry L, Gendron T, Petrucelli L, Martin F, Lagier-Tourenne C. CUG initiation and frameshifting enable production of dipeptide repeat proteins from ALS/FTD C9ORF72 transcripts. Nature Communications. 9: 152. PMID 29323119 DOI: 10.1038/S41467-017-02643-5  0.388
2018 Chou CC, Zhang Y, Umoh ME, Vaughan SW, Lorenzini I, Liu F, Sayegh M, Donlin-Asp PG, Chen YH, Duong DM, Seyfried NT, Powers MA, Kukar T, Hales CM, Gearing M, ... ... Petrucelli L, et al. TDP-43 pathology disrupts nuclear pore complexes and nucleocytoplasmic transport in ALS/FTD. Nature Neuroscience. PMID 29311743 DOI: 10.1038/S41593-017-0047-3  0.432
2018 Swinnen B, Bento-Abreu A, Gendron TF, Boeynaems S, Bogaert E, Nuyts R, Timmers M, Scheveneels W, Hersmus N, Wang J, Mizielinska S, Isaacs AM, Petrucelli L, Lemmens R, Van Damme P, et al. A zebrafish model for C9orf72 ALS reveals RNA toxicity as a pathogenic mechanism. Acta Neuropathologica. PMID 29302778 DOI: 10.1007/S00401-017-1796-5  0.375
2017 McGoldrick P, Zhang M, van Blitterswijk M, Sato C, Moreno D, Xiao S, Zhang AB, McKeever PM, Weichert A, Schneider R, Keith J, Petrucelli L, Rademakers R, Zinman L, Robertson J, et al. Unaffected mosaic C9orf72 case: RNA foci, dipeptide proteins, but upregulated C9orf72 expression. Neurology. PMID 29282338 DOI: 10.1212/Wnl.0000000000004865  0.405
2017 Farhan SMK, Gendron TF, Petrucelli L, Hegele RA, Strong MJ. OPTN p.Met468Arg and ATXN2 intermediate length polyQ extension in families with C9orf72 mediated amyotrophic lateral sclerosis and frontotemporal dementia. American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics. PMID 29080331 DOI: 10.1002/Ajmg.B.32606  0.412
2017 Lee YB, Baskaran P, Gomez J, Chen HJ, Nishimura A, Smith B, Troakes C, Adachi Y, Stepto A, Petrucelli L, Gallo JM, Hirth F, Rogelj B, Guthrie S, Shaw CE. C9orf72 poly GA RAN-translated protein plays a key role in Amyotrophic Lateral Sclerosis via aggregation and toxicity. Human Molecular Genetics. PMID 28973350 DOI: 10.1093/Hmg/Ddx350  0.336
2017 Josephs KA, Dickson DW, Tosakulwong N, Weigand SD, Murray ME, Petrucelli L, Liesinger AM, Senjem ML, Spychalla AJ, Knopman DS, Parisi JE, Petersen RC, Jack CR, Whitwell JL. Rates of hippocampal atrophy and presence of post-mortem TDP-43 in patients with Alzheimer's disease: a longitudinal retrospective study. The Lancet. Neurology. PMID 28919059 DOI: 10.1016/S1474-4422(17)30284-3  0.368
2017 Mackenzie IR, Nicholson AM, Sarkar M, Messing J, Purice MD, Pottier C, Annu K, Baker M, Perkerson RB, Kurti A, Matchett BJ, Mittag T, Temirov J, Hsiung GR, Krieger C, ... ... Petrucelli L, et al. TIA1 Mutations in Amyotrophic Lateral Sclerosis and Frontotemporal Dementia Promote Phase Separation and Alter Stress Granule Dynamics. Neuron. 95: 808-816.e9. PMID 28817800 DOI: 10.1016/J.Neuron.2017.07.025  0.392
2017 Carlomagno Y, Chung DC, Yue M, Castanedes-Casey M, Madden BJ, Dunmore J, Tong J, DeTure M, Dickson DW, Petrucelli L, Cook C. An acetylation-phosphorylation switch that regulates tau aggregation propensity and function. The Journal of Biological Chemistry. PMID 28760828 DOI: 10.1074/Jbc.M117.794602  0.366
2017 Lee CW, Stankowski JN, Chew J, Cook CN, Lam YW, Almeida S, Carlomagno Y, Lau KF, Prudencio M, Gao FB, Bogyo M, Dickson DW, Petrucelli L. The lysosomal protein cathepsin L is a progranulin protease. Molecular Neurodegeneration. 12: 55. PMID 28743268 DOI: 10.1186/S13024-017-0196-6  0.627
2017 Wojtas AM, Kang SS, Olley BM, Gatherer M, Shinohara M, Lozano PA, Liu CC, Kurti A, Baker KE, Dickson DW, Yue M, Petrucelli L, Bu G, Carare RO, Fryer JD. Loss of clusterin shifts amyloid deposition to the cerebrovasculature via disruption of perivascular drainage pathways. Proceedings of the National Academy of Sciences of the United States of America. PMID 28701379 DOI: 10.1016/J.Jalz.2017.06.250  0.334
2017 Prudencio M, Gonzales PK, Cook CN, Gendron TF, Daughrity LM, Song Y, Ebbert MTW, van Blitterswijk M, Zhang YJ, Jansen-West K, Baker MC, DeTure M, Rademakers R, Boylan KB, Dickson DW, ... Petrucelli L, et al. Repetitive element transcripts are elevated in the brain of C9orf72 ALS/FTLD patients. Human Molecular Genetics. PMID 28637276 DOI: 10.1093/Hmg/Ddx233  0.648
2017 Gendron TF, Daughrity LM, Heckman MG, Diehl NN, Wuu J, Miller TM, Pastor P, Trojanowski JQ, Grossman M, Berry JD, Hu WT, Ratti A, Benatar M, Silani V, Glass JD, ... ... Petrucelli L, et al. Phosphorylated neurofilament heavy chain: A biomarker of survival for C9ORF72-associated amyotrophic lateral sclerosis. Annals of Neurology. PMID 28628244 DOI: 10.1002/Ana.24980  0.331
2017 Petrucelli L, Gitler AD. Unlocking the Mystery of ALS. Scientific American. 316: 46-51. PMID 28510559 DOI: 10.1038/Scientificamerican0617-46  0.336
2017 DeJesus-Hernandez M, Finch NA, Wang X, Gendron TF, Bieniek KF, Heckman MG, Vasilevich A, Murray ME, Rousseau L, Weesner R, Lucido A, Parsons M, Chew J, Josephs KA, Parisi JE, ... ... Petrucelli L, et al. In-depth clinico-pathological examination of RNA foci in a large cohort of C9ORF72 expansion carriers. Acta Neuropathologica. PMID 28508101 DOI: 10.1007/S00401-017-1725-7  0.337
2017 Kawamata H, Peixoto P, Konrad C, Palomo G, Bredvik K, Gerges M, Valsecchi F, Petrucelli L, Ravits JM, Starkov A, Manfredi G. Mutant TDP-43 does not impair mitochondrial bioenergetics in vitro and in vivo. Molecular Neurodegeneration. 12: 37. PMID 28482850 DOI: 10.1186/S13024-017-0180-1  0.327
2017 Schludi MH, Becker L, Garrett L, Gendron TF, Zhou Q, Schreiber F, Popper B, Dimou L, Strom TM, Winkelmann J, von Thaden A, Rentzsch K, May S, Michaelsen M, Schwenk BM, ... ... Petrucelli L, et al. Spinal poly-GA inclusions in a C9orf72 mouse model trigger motor deficits and inflammation without neuron loss. Acta Neuropathologica. PMID 28409281 DOI: 10.1007/S00401-017-1711-0  0.372
2017 Gendron TF, Chew J, Stankowski JN, Hayes LR, Zhang YJ, Prudencio M, Carlomagno Y, Daughrity LM, Jansen-West K, Perkerson EA, O'Raw A, Cook C, Pregent L, Belzil V, van Blitterswijk M, ... ... Petrucelli L, et al. Poly(GP) proteins are a useful pharmacodynamic marker for C9ORF72-associated amyotrophic lateral sclerosis. Science Translational Medicine. 9. PMID 28356511 DOI: 10.1126/Scitranslmed.Aai7866  0.673
2017 Moujalled D, Grubman A, Acevedo K, Yang S, Ke YD, Moujalled DM, Duncan C, Caragounis A, Perera ND, Turner BJ, Prudencio M, Petrucelli L, Blair I, Ittner LM, Crouch PJ, et al. TDP-43 mutations causing amyotrophic lateral sclerosis are associated with altered expression of RNA-binding protein hnRNP K and affect the Nrf2 antioxidant pathway. Human Molecular Genetics. PMID 28334913 DOI: 10.1093/Hmg/Ddx093  0.673
2017 Josephs KA, Murray ME, Tosakulwong N, Whitwell JL, Knopman DS, Machulda MM, Weigand SD, Boeve BF, Kantarci K, Petrucelli L, Lowe VJ, Jack CR, Petersen RC, Parisi JE, Dickson DW. Tau aggregation influences cognition and hippocampal atrophy in the absence of beta-amyloid: a clinico-imaging-pathological study of primary age-related tauopathy (PART). Acta Neuropathologica. PMID 28160067 DOI: 10.1007/S00401-017-1681-2  0.319
2017 Gendron TF, Petrucelli L. Disease Mechanisms of C9ORF72 Repeat Expansions. Cold Spring Harbor Perspectives in Medicine. PMID 28130314 DOI: 10.1101/Cshperspect.A024224  0.436
2017 Petrucelli L. C9RAN PROTEINS AS A HALLMARK FOR C9ORF72-LINKED FTD AND ALS (C9FTD/ALS) Alzheimer's & Dementia. 13: P1444. DOI: 10.1016/J.Jalz.2017.07.473  0.336
2016 Vatsavayai SC, Yoon SJ, Gardner RC, Gendron TF, Vargas JN, Trujillo A, Pribadi M, Phillips JJ, Gaus SE, Hixson JD, Garcia PA, Rabinovici GD, Coppola G, Geschwind DH, Petrucelli L, et al. Timing and significance of pathological features in C9orf72 expansion-associated frontotemporal dementia. Brain : a Journal of Neurology. PMID 27797809 DOI: 10.1093/Brain/Aww250  0.383
2016 Tian F, Yang W, Mordes DA, Wang JY, Salameh JS, Mok J, Chew J, Sharma A, Leno-Duran E, Suzuki-Uematsu S, Suzuki N, Han SS, Lu FK, Ji M, Zhang R, ... ... Petrucelli L, et al. Monitoring peripheral nerve degeneration in ALS by label-free stimulated Raman scattering imaging. Nature Communications. 7: 13283. PMID 27796305 DOI: 10.1038/Ncomms13283  0.317
2016 Lopez-Gonzalez R, Lu Y, Gendron TF, Karydas A, Tran H, Yang D, Petrucelli L, Miller BL, Almeida S, Gao FB. Poly(GR) in C9ORF72-Related ALS/FTD Compromises Mitochondrial Function and Increases Oxidative Stress and DNA Damage in iPSC-Derived Motor Neurons. Neuron. PMID 27720481 DOI: 10.1016/J.Neuron.2016.09.015  0.318
2016 Tacik P, DeTure MA, Yari C, Lin WL, Murray ME, Baker MC, Josephs KA, Boeve BF, Wszolek ZK, Graff-Radford NR, Parisi JE, Petrucelli L, Rademakers R, Isaacson RS, Heilman KM, et al. FTDP-17 with pick body-like inclusions associated with a novel tau mutation, p.E372G. Brain Pathology (Zurich, Switzerland). PMID 27529406 DOI: 10.1111/Bpa.12428  0.355
2016 Kramer NJ, Carlomagno Y, Zhang YJ, Almeida S, Cook CN, Gendron TF, Prudencio M, Van Blitterswijk M, Belzil V, Couthouis J, Paul JW, Goodman LD, Daughrity L, Chew J, Garrett A, ... ... Petrucelli L, et al. Spt4 selectively regulates the expression of C9orf72 sense and antisense mutant transcripts. Science (New York, N.Y.). 353: 708-12. PMID 27516603 DOI: 10.1126/Science.Aaf7791  0.791
2016 Lowe VJ, Curran G, Fang P, Liesinger AM, Josephs KA, Parisi JE, Kantarci K, Boeve BF, Pandey MK, Bruinsma T, Knopman DS, Jones DT, Petrucelli L, Cook CN, Graff-Radford NR, et al. An autoradiographic evaluation of AV-1451 Tau PET in dementia. Acta Neuropathologica Communications. 4: 58. PMID 27296779 DOI: 10.1186/S40478-016-0315-6  0.333
2016 Belzil VV, Katzman RB, Petrucelli L. ALS and FTD: an epigenetic perspective. Acta Neuropathologica. PMID 27282474 DOI: 10.1007/S00401-016-1587-4  0.395
2016 Vanderweyde T, Apicco DJ, Youmans-Kidder K, Ash PE, Cook C, Lummertz da Rocha E, Jansen-West K, Frame AA, Citro A, Leszyk JD, Ivanov P, Abisambra JF, Steffen M, Li H, Petrucelli L, et al. Interaction of tau with the RNA-binding Protein TIA1 Regulates tau Pathophysiology and Toxicity. Cell Reports. PMID 27160897 DOI: 10.1016/J.Celrep.2016.04.045  0.408
2016 Jiang J, Zhu Q, Gendron TF, Saberi S, McAlonis-Downes M, Seelman A, Stauffer JE, Jafar-Nejad P, Drenner K, Schulte D, Chun S, Sun S, Ling SC, Myers B, Engelhardt J, ... ... Petrucelli L, et al. Gain of Toxicity from ALS/FTD-Linked Repeat Expansions in C9ORF72 Is Alleviated by Antisense Oligonucleotides Targeting GGGGCC-Containing RNAs. Neuron. PMID 27112497 DOI: 10.1016/J.Neuron.2016.04.006  0.419
2016 Todd TW, Petrucelli L. Insights into the pathogenic mechanisms of Chromosome 9 open reading frame 72 (C9orf72) repeat expansions. Journal of Neurochemistry. PMID 27016280 DOI: 10.1111/Jnc.13623  0.456
2016 Zhang YJ, Gendron TF, Grima JC, Sasaguri H, Jansen-West K, Xu YF, Katzman RB, Gass J, Murray ME, Shinohara M, Lin WL, Garrett A, Stankowski JN, Daughrity L, Tong J, ... ... Petrucelli L, et al. C9ORF72 poly(GA) aggregates sequester and impair HR23 and nucleocytoplasmic transport proteins. Nature Neuroscience. PMID 26998601 DOI: 10.1038/Nn.4272  0.355
2015 Esanov R, Belle KC, van Blitterswijk M, Belzil VV, Rademakers R, Dickson DW, Petrucelli L, Boylan KB, Dykxhoorn DM, Wuu J, Benatar M, Wahlestedt C, Zeier Z. C9orf72 promoter hypermethylation is reduced while hydroxymethylation is acquired during reprogramming of ALS patient cells. Experimental Neurology. PMID 26746986 DOI: 10.1016/J.Expneurol.2015.12.022  0.389
2015 Peters OM, Cabrera GT, Tran H, Gendron TF, McKeon JE, Metterville J, Weiss A, Wightman N, Salameh J, Kim J, Sun H, Boylan KB, Dickson D, Kennedy Z, Lin Z, ... ... Petrucelli L, et al. Human C9ORF72 Hexanucleotide Expansion Reproduces RNA Foci and Dipeptide Repeat Proteins but Not Neurodegeneration in BAC Transgenic Mice. Neuron. 88: 902-909. PMID 26637797 DOI: 10.1016/J.Neuron.2015.11.018  0.422
2015 O'Rourke JG, Bogdanik L, Muhammad AK, Gendron TF, Kim KJ, Austin A, Cady J, Liu EY, Zarrow J, Grant S, Ho R, Bell S, Carmona S, Simpkinson M, Lall D, ... ... Petrucelli L, et al. C9orf72 BAC Transgenic Mice Display Typical Pathologic Features of ALS/FTD. Neuron. 88: 892-901. PMID 26637796 DOI: 10.1016/J.Neuron.2015.10.027  0.397
2015 Mohagheghi F, Prudencio M, Stuani C, Cook C, Jansen-West K, Dickson DW, Petrucelli L, Buratti E. TDP-43 functions within a network of hnRNP proteins to inhibit the production of a truncated human SORT1 receptor. Human Molecular Genetics. PMID 26614389 DOI: 10.1093/Hmg/Ddv491  0.655
2015 van Blitterswijk M, Gendron TF, Baker MC, DeJesus-Hernandez M, Finch NA, Brown PH, Daughrity LM, Murray ME, Heckman MG, Jiang J, Lagier-Tourenne C, Edbauer D, Cleveland DW, Josephs KA, Parisi JE, ... ... Petrucelli L, et al. Novel clinical associations with specific C9ORF72 transcripts in patients with repeat expansions in C9ORF72. Acta Neuropathologica. PMID 26437865 DOI: 10.1007/S00401-015-1480-6  0.321
2015 Tran H, Almeida S, Moore J, Gendron TF, Chalasani U, Lu Y, Du X, Nickerson JA, Petrucelli L, Weng Z, Gao FB. Differential Toxicity of Nuclear RNA Foci versus Dipeptide Repeat Proteins in a Drosophila Model of C9ORF72 FTD/ALS. Neuron. 87: 1207-14. PMID 26402604 DOI: 10.1016/J.Neuron.2015.09.015  0.358
2015 Mackenzie IR, Frick P, Grässer FA, Gendron TF, Petrucelli L, Cashman NR, Edbauer D, Kremmer E, Prudlo J, Troost D, Neumann M. Quantitative analysis and clinico-pathological correlations of different dipeptide repeat protein pathologies in C9ORF72 mutation carriers. Acta Neuropathologica. PMID 26374446 DOI: 10.1007/S00401-015-1476-2  0.424
2015 Gendron TF, van Blitterswijk M, Bieniek KF, Daughrity LM, Jiang J, Rush BK, Pedraza O, Lucas JA, Murray ME, Desaro P, Robertson A, Overstreet K, Thomas CS, Crook JE, Castanedes-Casey M, ... ... Petrucelli L, et al. Cerebellar c9RAN proteins associate with clinical and neuropathological characteristics of C9ORF72 repeat expansion carriers. Acta Neuropathologica. 130: 559-73. PMID 26350237 DOI: 10.1007/S00401-015-1474-4  0.385
2015 Freibaum BD, Lu Y, Lopez-Gonzalez R, Kim NC, Almeida S, Lee KH, Badders N, Valentine M, Miller BL, Wong PC, Petrucelli L, Kim HJ, Gao FB, Taylor JP. GGGGCC repeat expansion in C9orf72 compromises nucleocytoplasmic transport. Nature. 525: 129-33. PMID 26308899 DOI: 10.1038/Nature14974  0.426
2015 Cook C, Kang SS, Carlomagno Y, Lin WL, Yue M, Kurti A, Shinohara M, Jansen-West K, Perkerson E, Castanedes-Casey M, Rousseau L, Phillips V, Bu G, Dickson DW, Petrucelli L, et al. Tau deposition drives neuropathological, inflammatory, and behavioral abnormalities independently of neuronal loss in a novel mouse model. Human Molecular Genetics. PMID 26276810 DOI: 10.1093/Hmg/Ddv336  0.412
2015 Josephs KA, Whitwell JL, Tosakulwong N, Weigand SD, Murray ME, Liesinger AM, Petrucelli L, Senjem ML, Ivnik RJ, Parisi JE, Petersen RC, Dickson DW. TAR DNA-binding protein 43 and pathological subtype of Alzheimer's disease impact clinical features. Annals of Neurology. PMID 26224156 DOI: 10.1002/Ana.24493  0.331
2015 Prudencio M, Belzil VV, Batra R, Ross CA, Gendron TF, Pregent LJ, Murray ME, Overstreet KK, Piazza-Johnston AE, Desaro P, Bieniek KF, DeTure M, Lee WC, Biendarra SM, Davis MD, ... ... Petrucelli L, et al. Distinct brain transcriptome profiles in C9orf72-associated and sporadic ALS. Nature Neuroscience. 18: 1175-82. PMID 26192745 DOI: 10.1038/Nn.4065  0.666
2015 Chew J, Gendron TF, Prudencio M, Sasaguri H, Zhang YJ, Castanedes-Casey M, Lee CW, Jansen-West K, Kurti A, Murray ME, Bieniek KF, Bauer PO, Whitelaw EC, Rousseau L, Stankowski JN, ... ... Petrucelli L, et al. Neurodegeneration. C9ORF72 repeat expansions in mice cause TDP-43 pathology, neuronal loss, and behavioral deficits. Science (New York, N.Y.). 348: 1151-4. PMID 25977373 DOI: 10.1126/Science.Aaa9344  0.677
2015 Tacik P, DeTure M, Lin WL, Sanchez Contreras M, Wojtas A, Hinkle KM, Fujioka S, Baker MC, Walton RL, Carlomagno Y, Brown PH, Strongosky AJ, Kouri N, Murray ME, Petrucelli L, et al. A novel tau mutation, p.K317N, causes globular glial tauopathy. Acta Neuropathologica. 130: 199-214. PMID 25900293 DOI: 10.1007/S00401-015-1425-0  0.373
2015 Ross OA, Cook C, Petrucelli L. Linking the VPS35 and EIF4G1 pathways in Parkinson's disease. Neuron. 85: 1-3. PMID 25569341 DOI: 10.1016/J.Neuron.2014.12.045  0.367
2015 Chew J, Gendron TF, Prudencio M, Sasaguri H, Zhang YJ, Castanedes-Casey M, Lee CW, Jansen-West K, Kurti A, Murray ME, Bieniek KF, Bauer PO, Whitelaw EC, Rousseau L, Stankowski JN, ... ... Petrucelli L, et al. C9ORF72 repeat expansions in mice cause TDP-43 pathology, neuronal loss, and behavioral deficits Science. 348: 1151-1154. DOI: 10.1126/science.aaa9344  0.58
2015 Vanderweyde T, Youmans-Kidder K, Apicco DJ, Ash PEA, Cook C, Petrucelli L, Wolozin B. Interaction between microtubule-associated protein tau and RNA binding proteins stimulates tau misfolding and stress granule formation Alzheimers & Dementia. 11. DOI: 10.1016/J.Jalz.2015.07.417  0.357
2014 Saldi TK, Ash PE, Wilson G, Gonzales P, Garrido-Lecca A, Roberts CM, Dostal V, Gendron TF, Stein LD, Blumenthal T, Petrucelli L, Link CD. TDP-1, the Caenorhabditis elegans ortholog of TDP-43, limits the accumulation of double-stranded RNA. The Embo Journal. 33: 2947-66. PMID 25391662 DOI: 10.15252/Embj.201488740  0.335
2014 van Blitterswijk M, Mullen B, Wojtas A, Heckman MG, Diehl NN, Baker MC, DeJesus-Hernandez M, Brown PH, Murray ME, Hsiung GY, Stewart H, Karydas AM, Finger E, Kertesz A, Bigio EH, ... ... Petrucelli L, et al. Genetic modifiers in carriers of repeat expansions in the C9ORF72 gene. Molecular Neurodegeneration. 9: 38. PMID 25239657 DOI: 10.1186/1750-1326-9-38  0.354
2014 Zhang YJ, Jansen-West K, Xu YF, Gendron TF, Bieniek KF, Lin WL, Sasaguri H, Caulfield T, Hubbard J, Daughrity L, Chew J, Belzil VV, Prudencio M, Stankowski JN, Castanedes-Casey M, ... ... Petrucelli L, et al. Aggregation-prone c9FTD/ALS poly(GA) RAN-translated proteins cause neurotoxicity by inducing ER stress. Acta Neuropathologica. 128: 505-24. PMID 25173361 DOI: 10.1007/S00401-014-1336-5  0.678
2014 Su Z, Zhang Y, Gendron TF, Bauer PO, Chew J, Yang WY, Fostvedt E, Jansen-West K, Belzil VV, Desaro P, Johnston A, Overstreet K, Oh SY, Todd PK, Berry JD, ... ... Petrucelli L, et al. Discovery of a biomarker and lead small molecules to target r(GGGGCC)-associated defects in c9FTD/ALS. Neuron. 83: 1043-50. PMID 25132468 DOI: 10.1016/J.Neuron.2014.07.041  0.322
2014 Cook C, Stankowski JN, Carlomagno Y, Stetler C, Petrucelli L. Acetylation: a new key to unlock tau's role in neurodegeneration. Alzheimer's Research & Therapy. 6: 29. PMID 25031639 DOI: 10.1186/Alzrt259  0.366
2014 Stoica R, De Vos KJ, Paillusson S, Mueller S, Sancho RM, Lau KF, Vizcay-Barrena G, Lin WL, Xu YF, Lewis J, Dickson DW, Petrucelli L, Mitchell JC, Shaw CE, Miller CC. ER-mitochondria associations are regulated by the VAPB-PTPIP51 interaction and are disrupted by ALS/FTD-associated TDP-43. Nature Communications. 5: 3996. PMID 24893131 DOI: 10.1038/Ncomms4996  0.325
2014 van Blitterswijk M, Mullen B, Heckman MG, Baker MC, DeJesus-Hernandez M, Brown PH, Murray ME, Hsiung GY, Stewart H, Karydas AM, Finger E, Kertesz A, Bigio EH, Weintraub S, Mesulam M, ... ... Petrucelli L, et al. Ataxin-2 as potential disease modifier in C9ORF72 expansion carriers. Neurobiology of Aging. 35: 2421.e13-7. PMID 24866401 DOI: 10.1016/J.Neurobiolaging.2014.04.016  0.37
2014 Bieniek KF, van Blitterswijk M, Baker MC, Petrucelli L, Rademakers R, Dickson DW. Expanded C9ORF72 hexanucleotide repeat in depressive pseudodementia. Jama Neurology. 71: 775-81. PMID 24756204 DOI: 10.1001/Jamaneurol.2013.6368  0.332
2014 Josephs KA, Whitwell JL, Weigand SD, Murray ME, Tosakulwong N, Liesinger AM, Petrucelli L, Senjem ML, Knopman DS, Boeve BF, Ivnik RJ, Smith GE, Jack CR, Parisi JE, Petersen RC, et al. TDP-43 is a key player in the clinical features associated with Alzheimer's disease. Acta Neuropathologica. 127: 811-24. PMID 24659241 DOI: 10.1007/S00401-014-1269-Z  0.321
2014 Liu-Yesucevitz L, Lin AY, Ebata A, Boon JY, Reid W, Xu YF, Kobrin K, Murphy GJ, Petrucelli L, Wolozin B. ALS-linked mutations enlarge TDP-43-enriched neuronal RNA granules in the dendritic arbor. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 34: 4167-74. PMID 24647938 DOI: 10.1523/Jneurosci.2350-13.2014  0.385
2014 Carlomagno Y, Zhang Y, Davis M, Lin WL, Cook C, Dunmore J, Tay W, Menkosky K, Cao X, Petrucelli L, Deture M. Casein kinase II induced polymerization of soluble TDP-43 into filaments is inhibited by heat shock proteins. Plos One. 9: e90452. PMID 24595055 DOI: 10.1371/Journal.Pone.0090452  0.4
2014 Belzil VV, Bauer PO, Gendron TF, Murray ME, Dickson D, Petrucelli L. Characterization of DNA hypermethylation in the cerebellum of c9FTD/ALS patients. Brain Research. 1584: 15-21. PMID 24530272 DOI: 10.1016/J.Brainres.2014.02.015  0.374
2014 Cook C, Dunmore JH, Murray ME, Scheffel K, Shukoor N, Tong J, Castanedes-Casey M, Phillips V, Rousseau L, Penuliar MS, Kurti A, Dickson DW, Petrucelli L, Fryer JD. Severe amygdala dysfunction in a MAPT transgenic mouse model of frontotemporal dementia. Neurobiology of Aging. 35: 1769-77. PMID 24503275 DOI: 10.1016/J.Neurobiolaging.2013.12.023  0.323
2014 D'Alton S, Altshuler M, Cannon A, Dickson DW, Petrucelli L, Lewis J. Divergent phenotypes in mutant TDP-43 transgenic mice highlight potential confounds in TDP-43 transgenic modeling. Plos One. 9: e86513. PMID 24466128 DOI: 10.1371/Journal.Pone.0086513  0.394
2014 Gendron TF, Belzil VV, Zhang YJ, Petrucelli L. Mechanisms of toxicity in C9FTLD/ALS. Acta Neuropathologica. 127: 359-76. PMID 24394885 DOI: 10.1007/S00401-013-1237-Z  0.455
2014 van Blitterswijk M, Mullen B, Nicholson AM, Bieniek KF, Heckman MG, Baker MC, DeJesus-Hernandez M, Finch NA, Brown PH, Murray ME, Hsiung GY, Stewart H, Karydas AM, Finger E, Kertesz A, ... ... Petrucelli L, et al. TMEM106B protects C9ORF72 expansion carriers against frontotemporal dementia. Acta Neuropathologica. 127: 397-406. PMID 24385136 DOI: 10.1007/S00401-013-1240-4  0.358
2014 Lee WC, Almeida S, Prudencio M, Caulfield TR, Zhang YJ, Tay WM, Bauer PO, Chew J, Sasaguri H, Jansen-West KR, Gendron TF, Stetler CT, Finch N, Mackenzie IR, Rademakers R, ... ... Petrucelli L, et al. Targeted manipulation of the sortilin-progranulin axis rescues progranulin haploinsufficiency. Human Molecular Genetics. 23: 1467-78. PMID 24163244 DOI: 10.1093/Hmg/Ddt534  0.634
2014 Kouri N, Carlomagno Y, Baker M, Liesinger AM, Caselli RJ, Wszolek ZK, Petrucelli L, Boeve BF, Parisi JE, Josephs KA, Uitti RJ, Ross OA, Graff-Radford NR, DeTure MA, Dickson DW, et al. Novel mutation in MAPT exon 13 (p.N410H) causes corticobasal degeneration. Acta Neuropathologica. 127: 271-82. PMID 24121548 DOI: 10.1007/S00401-013-1193-7  0.354
2014 Cook C, Carlomagno Y, Gendron TF, Dunmore J, Scheffel K, Stetler C, Davis M, Dickson D, Jarpe M, DeTure M, Petrucelli L. Acetylation of the KXGS motifs in tau is a critical determinant in modulation of tau aggregation and clearance. Human Molecular Genetics. 23: 104-16. PMID 23962722 DOI: 10.1093/Hmg/Ddt402  0.38
2014 Belzil VV, Petrucelli L. Epigenetic modifications of the C9ORF72 gene: A potential biomarker of disease? Future Neurology. 9: 123-126. DOI: 10.2217/Fnl.14.5  0.427
2014 Almeida S, Gascon E, Tran H, Chou HJ, Gendron TF, DeGroot S, Tapper AR, Sellier C, Charlet-Berguerand N, Karydas A, Seeley WW, Boxer AL, Petrucelli L, Miller BL, Gao F. Erratum to: Modeling key pathological features of frontotemporal dementia with C9ORF72 repeat expansion in iPSC-derived human neurons Acta Neuropathologica. 127: 941-941. DOI: 10.1007/S00401-014-1275-1  0.316
2013 Mann DM, Rollinson S, Robinson A, Bennion Callister J, Thompson JC, Snowden JS, Gendron T, Petrucelli L, Masuda-Suzukake M, Hasegawa M, Davidson Y, Pickering-Brown S. Dipeptide repeat proteins are present in the p62 positive inclusions in patients with frontotemporal lobar degeneration and motor neurone disease associated with expansions in C9ORF72. Acta Neuropathologica Communications. 1: 68. PMID 24252525 DOI: 10.1186/2051-5960-1-68  0.339
2013 Belzil VV, Bauer PO, Prudencio M, Gendron TF, Stetler CT, Yan IK, Pregent L, Daughrity L, Baker MC, Rademakers R, Boylan K, Patel TC, Dickson DW, Petrucelli L. Reduced C9orf72 gene expression in c9FTD/ALS is caused by histone trimethylation, an epigenetic event detectable in blood. Acta Neuropathologica. 126: 895-905. PMID 24166615 DOI: 10.1007/S00401-013-1199-1  0.647
2013 Sareen D, O'Rourke JG, Meera P, Muhammad AK, Grant S, Simpkinson M, Bell S, Carmona S, Ornelas L, Sahabian A, Gendron T, Petrucelli L, Baughn M, Ravits J, Harms MB, et al. Targeting RNA foci in iPSC-derived motor neurons from ALS patients with a C9ORF72 repeat expansion. Science Translational Medicine. 5: 208ra149. PMID 24154603 DOI: 10.1126/Scitranslmed.3007529  0.391
2013 Donnelly CJ, Zhang PW, Pham JT, Haeusler AR, Heusler AR, Mistry NA, Vidensky S, Daley EL, Poth EM, Hoover B, Fines DM, Maragakis N, Tienari PJ, Petrucelli L, Traynor BJ, et al. RNA toxicity from the ALS/FTD C9ORF72 expansion is mitigated by antisense intervention. Neuron. 80: 415-28. PMID 24139042 DOI: 10.1016/J.Neuron.2013.10.015  0.452
2013 Gendron TF, Bieniek KF, Zhang YJ, Jansen-West K, Ash PE, Caulfield T, Daughrity L, Dunmore JH, Castanedes-Casey M, Chew J, Cosio DM, van Blitterswijk M, Lee WC, Rademakers R, Boylan KB, ... ... Petrucelli L, et al. Antisense transcripts of the expanded C9ORF72 hexanucleotide repeat form nuclear RNA foci and undergo repeat-associated non-ATG translation in c9FTD/ALS. Acta Neuropathologica. 126: 829-44. PMID 24129584 DOI: 10.1007/S00401-013-1192-8  0.442
2013 van Blitterswijk M, Baker MC, DeJesus-Hernandez M, Ghidoni R, Benussi L, Finger E, Hsiung GY, Kelley BJ, Murray ME, Rutherford NJ, Brown PE, Ravenscroft T, Mullen B, Ash PE, Bieniek KF, ... ... Petrucelli L, et al. C9ORF72 repeat expansions in cases with previously identified pathogenic mutations. Neurology. 81: 1332-41. PMID 24027057 DOI: 10.1212/Wnl.0B013E3182A8250C  0.341
2013 van Blitterswijk M, DeJesus-Hernandez M, Niemantsverdriet E, Murray ME, Heckman MG, Diehl NN, Brown PH, Baker MC, Finch NA, Bauer PO, Serrano G, Beach TG, Josephs KA, Knopman DS, Petersen RC, ... ... Petrucelli L, et al. Association between repeat sizes and clinical and pathological characteristics in carriers of C9ORF72 repeat expansions (Xpansize-72): a cross-sectional cohort study. The Lancet. Neurology. 12: 978-88. PMID 24011653 DOI: 10.1016/S1474-4422(13)70210-2  0.342
2013 Murray ME, Bieniek KF, Banks Greenberg M, DeJesus-Hernandez M, Rutherford NJ, van Blitterswijk M, Niemantsverdriet E, Ash PE, Gendron TF, Kouri N, Baker M, Goodman IJ, Petrucelli L, Rademakers R, Dickson DW. Progressive amnestic dementia, hippocampal sclerosis, and mutation in C9ORF72. Acta Neuropathologica. 126: 545-54. PMID 23922030 DOI: 10.1007/S00401-013-1161-2  0.419
2013 Gendron TF, Cosio DM, Petrucelli L. c9RAN translation: a potential therapeutic target for the treatment of amyotrophic lateral sclerosis and frontotemporal dementia. Expert Opinion On Therapeutic Targets. 17: 991-5. PMID 23844663 DOI: 10.1517/14728222.2013.818659  0.434
2013 Almeida S, Gascon E, Tran H, Chou HJ, Gendron TF, Degroot S, Tapper AR, Sellier C, Charlet-Berguerand N, Karydas A, Seeley WW, Boxer AL, Petrucelli L, Miller BL, Gao FB. Modeling key pathological features of frontotemporal dementia with C9ORF72 repeat expansion in iPSC-derived human neurons. Acta Neuropathologica. 126: 385-99. PMID 23836290 DOI: 10.1007/S00401-013-1149-Y  0.38
2013 Wang W, Li L, Lin WL, Dickson DW, Petrucelli L, Zhang T, Wang X. The ALS disease-associated mutant TDP-43 impairs mitochondrial dynamics and function in motor neurons. Human Molecular Genetics. 22: 4706-19. PMID 23827948 DOI: 10.1093/Hmg/Ddt319  0.314
2013 Fratta P, Poulter M, Lashley T, Rohrer JD, Polke JM, Beck J, Ryan N, Hensman D, Mizielinska S, Waite AJ, Lai MC, Gendron TF, Petrucelli L, Fisher EM, Revesz T, et al. Homozygosity for the C9orf72 GGGGCC repeat expansion in frontotemporal dementia. Acta Neuropathologica. 126: 401-9. PMID 23818065 DOI: 10.1007/S00401-013-1147-0  0.576
2013 Dayton RD, Gitcho MA, Orchard EA, Wilson JD, Wang DB, Cain CD, Johnson JA, Zhang YJ, Petrucelli L, Mathis JM, Klein RL. Selective forelimb impairment in rats expressing a pathological TDP-43 25 kDa C-terminal fragment to mimic amyotrophic lateral sclerosis. Molecular Therapy : the Journal of the American Society of Gene Therapy. 21: 1324-34. PMID 23689600 DOI: 10.1038/Mt.2013.88  0.413
2013 Clippinger AK, D'Alton S, Lin WL, Gendron TF, Howard J, Borchelt DR, Cannon A, Carlomagno Y, Chakrabarty P, Cook C, Golde TE, Levites Y, Ranum L, Schultheis PJ, Xu G, ... Petrucelli L, et al. Robust cytoplasmic accumulation of phosphorylated TDP-43 in transgenic models of tauopathy. Acta Neuropathologica. 126: 39-50. PMID 23666556 DOI: 10.1007/S00401-013-1123-8  0.596
2013 Zhang YJ, Caulfield T, Xu YF, Gendron TF, Hubbard J, Stetler C, Sasaguri H, Whitelaw EC, Cai S, Lee WC, Petrucelli L. The dual functions of the extreme N-terminus of TDP-43 in regulating its biological activity and inclusion formation. Human Molecular Genetics. 22: 3112-22. PMID 23575225 DOI: 10.1093/Hmg/Ddt166  0.387
2013 Ash PE, Bieniek KF, Gendron TF, Caulfield T, Lin WL, Dejesus-Hernandez M, van Blitterswijk MM, Jansen-West K, Paul JW, Rademakers R, Boylan KB, Dickson DW, Petrucelli L. Unconventional translation of C9ORF72 GGGGCC expansion generates insoluble polypeptides specific to c9FTD/ALS. Neuron. 77: 639-46. PMID 23415312 DOI: 10.1016/J.Neuron.2013.02.004  0.769
2013 Belzil VV, Gendron TF, Petrucelli L. RNA-mediated toxicity in neurodegenerative disease. Molecular and Cellular Neurosciences. 56: 406-19. PMID 23280309 DOI: 10.1016/J.Mcn.2012.12.006  0.358
2013 Rayaprolu S, Fujioka S, Traynor S, Soto-Ortolaza AI, Petrucelli L, Dickson DW, Rademakers R, Boylan KB, Graff-Radford NR, Uitti RJ, Wszolek ZK, Ross OA. TARDBP mutations in Parkinson's disease. Parkinsonism & Related Disorders. 19: 312-5. PMID 23231971 DOI: 10.1016/J.Parkreldis.2012.11.003  0.379
2013 Gendron TF, Rademakers R, Petrucelli L. TARDBP mutation analysis in TDP-43 proteinopathies and deciphering the toxicity of mutant TDP-43. Journal of Alzheimer's Disease : Jad. 33: S35-45. PMID 22751173 DOI: 10.3233/Jad-2012-129036  0.411
2013 Cook C, Petrucelli L. Tau triage decisions mediated by the chaperone network. Journal of Alzheimer's Disease : Jad. 33: S145-51. PMID 22596270 DOI: 10.3233/Jad-2012-129008  0.372
2013 Donnelly CJ, Zhang PW, Pham JT, Haeusler AR, Mistry NA, Vidensky S, Daley EL, Poth EM, Hoover B, Fines DM, Maragakis N, Tienari PJ, Petrucelli L, Traynor BJ, Wang J, et al. RNA Toxicity from the ALS/FTD C9ORF72 expansion is mitigated by antisense intervention [Neuron, 79, (September 18, 2013), 1222-1231] Neuron. 80: 1102. DOI: 10.1016/J.Neuron.2013.10.055  0.335
2013 Wolozin B, Vanderwyede T, Liu-Yesucevitz L, Dedeoglu A, Petrucelli L, Duff K. P4-034: Viewing neurodegeneration beyond the tangle: The role of RNA binding proteins in Alzheimer's disease Alzheimer's & Dementia. 9: P715-P716. DOI: 10.1016/J.Jalz.2013.05.1422  0.56
2012 Prudencio M, Jansen-West KR, Lee WC, Gendron TF, Zhang YJ, Xu YF, Gass J, Stuani C, Stetler C, Rademakers R, Dickson DW, Buratti E, Petrucelli L. Misregulation of human sortilin splicing leads to the generation of a nonfunctional progranulin receptor. Proceedings of the National Academy of Sciences of the United States of America. 109: 21510-5. PMID 23236149 DOI: 10.1073/Pnas.1211577110  0.65
2012 Vaccaro A, Tauffenberger A, Ash PE, Carlomagno Y, Petrucelli L, Parker JA. TDP-1/TDP-43 regulates stress signaling and age-dependent proteotoxicity in Caenorhabditis elegans. Plos Genetics. 8: e1002806. PMID 22792076 DOI: 10.1371/Journal.Pgen.1002806  0.386
2012 Gass J, Lee WC, Cook C, Finch N, Stetler C, Jansen-West K, Lewis J, Link CD, Rademakers R, Nykjær A, Petrucelli L. Progranulin regulates neuronal outgrowth independent of sortilin. Molecular Neurodegeneration. 7: 33. PMID 22781549 DOI: 10.1186/1750-1326-7-33  0.338
2012 Cook C, Stetler C, Petrucelli L. Disruption of protein quality control in Parkinson's disease. Cold Spring Harbor Perspectives in Medicine. 2: a009423. PMID 22553500 DOI: 10.1101/Cshperspect.A009423  0.358
2012 Cannon A, Yang B, Knight J, Farnham IM, Zhang Y, Wuertzer CA, D'Alton S, Lin WL, Castanedes-Casey M, Rousseau L, Scott B, Jurasic M, Howard J, Yu X, Bailey R, ... ... Petrucelli L, et al. Neuronal sensitivity to TDP-43 overexpression is dependent on timing of induction. Acta Neuropathologica. 123: 807-23. PMID 22539017 DOI: 10.1007/S00401-012-0979-3  0.359
2012 Cook C, Gendron TF, Scheffel K, Carlomagno Y, Dunmore J, DeTure M, Petrucelli L. Loss of HDAC6, a novel CHIP substrate, alleviates abnormal tau accumulation. Human Molecular Genetics. 21: 2936-45. PMID 22492994 DOI: 10.1093/Hmg/Dds125  0.402
2012 Gass J, Prudencio M, Stetler C, Petrucelli L. Progranulin: an emerging target for FTLD therapies. Brain Research. 1462: 118-28. PMID 22338605 DOI: 10.1016/J.Brainres.2012.01.047  0.673
2012 Nicholson AM, Gass J, Petrucelli L, Rademakers R. Progranulin axis and recent developments in frontotemporal lobar degeneration. Alzheimer's Research & Therapy. 4: 4. PMID 22277331 DOI: 10.1186/Alzrt102  0.382
2012 Petrucelli L. Mechanisms and models of TDP-43 proteinopathies Molecular Neurodegeneration. 7: L19. DOI: 10.1186/1750-1326-7-S1-L19  0.446
2011 Xu YF, Zhang YJ, Lin WL, Cao X, Stetler C, Dickson DW, Lewis J, Petrucelli L. Expression of mutant TDP-43 induces neuronal dysfunction in transgenic mice. Molecular Neurodegeneration. 6: 73. PMID 22029574 DOI: 10.1186/1750-1326-6-73  0.458
2011 Gendron TF, Petrucelli L. Rodent models of TDP-43 proteinopathy: investigating the mechanisms of TDP-43-mediated neurodegeneration. Journal of Molecular Neuroscience : Mn. 45: 486-99. PMID 21811811 DOI: 10.1007/S12031-011-9610-7  0.414
2010 Liu-Yesucevitz L, Bilgutay A, Zhang YJ, Vanderweyde T, Vanderwyde T, Citro A, Mehta T, Zaarur N, McKee A, Bowser R, Sherman M, Petrucelli L, Wolozin B. Tar DNA binding protein-43 (TDP-43) associates with stress granules: analysis of cultured cells and pathological brain tissue. Plos One. 5: e13250. PMID 20948999 DOI: 10.1371/Journal.Pone.0013250  0.416
2010 Zhang YJ, Gendron TF, Xu YF, Ko LW, Yen SH, Petrucelli L. Phosphorylation regulates proteasomal-mediated degradation and solubility of TAR DNA binding protein-43 C-terminal fragments. Molecular Neurodegeneration. 5: 33. PMID 20804554 DOI: 10.1186/1750-1326-5-33  0.377
2010 Lee BD, Shin JH, VanKampen J, Petrucelli L, West AB, Ko HS, Lee YI, Maguire-Zeiss KA, Bowers WJ, Federoff HJ, Dawson VL, Dawson TM. Inhibitors of leucine-rich repeat kinase-2 protect against models of Parkinson's disease. Nature Medicine. 16: 998-1000. PMID 20729864 DOI: 10.1038/Nm.2199  0.313
2010 Xu YF, Gendron TF, Zhang YJ, Lin WL, D'Alton S, Sheng H, Casey MC, Tong J, Knight J, Yu X, Rademakers R, Boylan K, Hutton M, McGowan E, Dickson DW, ... ... Petrucelli L, et al. Wild-type human TDP-43 expression causes TDP-43 phosphorylation, mitochondrial aggregation, motor deficits, and early mortality in transgenic mice. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 30: 10851-9. PMID 20702714 DOI: 10.1523/Jneurosci.1630-10.2010  0.705
2010 Ash PE, Zhang YJ, Roberts CM, Saldi T, Hutter H, Buratti E, Petrucelli L, Link CD. Neurotoxic effects of TDP-43 overexpression in C. elegans. Human Molecular Genetics. 19: 3206-18. PMID 20530643 DOI: 10.1093/Hmg/Ddq230  0.389
2010 Ahmed Z, Sheng H, Xu YF, Lin WL, Innes AE, Gass J, Yu X, Wuertzer CA, Hou H, Chiba S, Yamanouchi K, Leissring M, Petrucelli L, Nishihara M, Hutton ML, et al. Accelerated lipofuscinosis and ubiquitination in granulin knockout mice suggest a role for progranulin in successful aging. The American Journal of Pathology. 177: 311-24. PMID 20522652 DOI: 10.2353/Ajpath.2010.090915  0.644
2010 Gendron TF, Josephs KA, Petrucelli L. Review: transactive response DNA-binding protein 43 (TDP-43): mechanisms of neurodegeneration. Neuropathology and Applied Neurobiology. 36: 97-112. PMID 20202122 DOI: 10.1111/J.1365-2990.2010.01060.X  0.418
2010 Golde TE, Petrucelli L, Lewis J. Targeting Abeta and tau in Alzheimer's disease, an early interim report. Experimental Neurology. 223: 252-66. PMID 19716367 DOI: 10.1016/J.Expneurol.2009.07.035  0.373
2010 Ahmed Z, Sheng H, Xu YF, Lin WL, Innes AE, Gass J, Yu X, Wuertzer CA, Hou H, Chiba S, Yamanouchi K, Leissring M, Petrucelli L, Nishihara M, Hutton ML, et al. Accelerated lipofuscinosis and ubiquitination in granulin knockout mice suggest a role for progranulin in successful aging (American Journal of Pathology (2010), 177, (311-324)) American Journal of Pathology. 177: 2146. DOI: 10.2353/Ajpath.2010.100772  0.612
2010 Xu Y, Gendron T, Zhang Y, Lin W, D'Alton S, Sheng H, Crook R, Casey MC, Tong J, Knight J, Yu X, Rademakers R, Boylan K, Hutton M, McGowan E, ... ... Petrucelli L, et al. P1-185: Wild-type human TDP-43 induces mitochondrial abnormalities and axonal degeneration in transgenic mice Alzheimer's & Dementia. 6: S227-S227. DOI: 10.1016/J.Jalz.2010.05.735  0.61
2010 Zhang Y, Gendron T, Xu Y, Ko L, Yen S, Petrucelli L. P1-165: Generation and characterization of FTLD-U and ALS cell model with inducible expression of TDP-43 C-terminal fragment Alzheimer's & Dementia. 6: S221-S222. DOI: 10.1016/J.Jalz.2010.05.715  0.301
2010 Ash PE, Saldi TK, Link CD, Petrucelli L. O1-07-03: Structure/function analysis of TDP-43 neurotoxicity in C. elegans Alzheimer's & Dementia. 6: S84-S84. DOI: 10.1016/J.Jalz.2010.05.251  0.417
2010 Ahmed Z, Sheng H, Xu Y, Lin W, Innes AE, Yu X, Hou H, Chiba S, Yamanouchi K, Petrucelli L, Nishihara M, Hutton ML, McGowan E, Dickson DW, Lewis J. Accelerated lipofuscinosis and ubiquitination in granulin knockout mice suggests a role for progranulin in successful aging Alzheimers & Dementia. 6. DOI: 10.1016/J.Jalz.2010.05.249  0.511
2009 Cook C, Gass J, Dunmore J, Tong J, Taylor J, Eriksen J, McGowan E, Lewis J, Johnston J, Petrucelli L. Aging is not associated with proteasome impairment in UPS reporter mice. Plos One. 4: e5888. PMID 19517018 DOI: 10.1371/Journal.Pone.0005888  0.59
2009 Cook C, Petrucelli L. A critical evaluation of the ubiquitin-proteasome system in Parkinson's disease. Biochimica Et Biophysica Acta. 1792: 664-75. PMID 19419700 DOI: 10.1016/J.Bbadis.2009.01.012  0.309
2009 Zhang YJ, Xu YF, Cook C, Gendron TF, Roettges P, Link CD, Lin WL, Tong J, Castanedes-Casey M, Ash P, Gass J, Rangachari V, Buratti E, Baralle F, Golde TE, ... ... Petrucelli L, et al. Aberrant cleavage of TDP-43 enhances aggregation and cellular toxicity. Proceedings of the National Academy of Sciences of the United States of America. 106: 7607-12. PMID 19383787 DOI: 10.1073/Pnas.0900688106  0.421
2009 Bett JS, Cook C, Petrucelli L, Bates GP. The ubiquitin-proteasome reporter GFPu does not accumulate in neurons of the R6/2 transgenic mouse model of Huntington's disease. Plos One. 4: e5128. PMID 19352500 DOI: 10.1371/Journal.Pone.0005128  0.391
2009 Gendron TF, Petrucelli L. The role of tau in neurodegeneration. Molecular Neurodegeneration. 4: 13. PMID 19284597 DOI: 10.1186/1750-1326-4-13  0.386
2009 Ko HS, Bailey R, Smith WW, Liu Z, Shin JH, Lee YI, Zhang YJ, Jiang H, Ross CA, Moore DJ, Patterson C, Petrucelli L, Dawson TM, Dawson VL. CHIP regulates leucine-rich repeat kinase-2 ubiquitination, degradation, and toxicity. Proceedings of the National Academy of Sciences of the United States of America. 106: 2897-902. PMID 19196961 DOI: 10.1073/Pnas.0810123106  0.347
2009 Golde TE, Petrucelli L. "What kills neurons in neurodegenerative diseases?", a review series in an open access journal. Molecular Neurodegeneration. 4: 7. PMID 19193221 DOI: 10.1186/1750-1326-4-7  0.341
2008 Ayala YM, Zago P, D'Ambrogio A, Xu YF, Petrucelli L, Buratti E, Baralle FE. Structural determinants of the cellular localization and shuttling of TDP-43. Journal of Cell Science. 121: 3778-85. PMID 18957508 DOI: 10.1242/Jcs.038950  0.399
2008 Rutherford NJ, Zhang YJ, Baker M, Gass JM, Finch NA, Xu YF, Stewart H, Kelley BJ, Kuntz K, Crook RJ, Sreedharan J, Vance C, Sorenson E, Lippa C, Bigio EH, ... ... Petrucelli L, et al. Novel mutations in TARDBP (TDP-43) in patients with familial amyotrophic lateral sclerosis. Plos Genetics. 4: e1000193. PMID 18802454 DOI: 10.1371/Journal.Pgen.1000193  0.567
2008 Cook C, Zhang YJ, Xu YF, Dickson DW, Petrucelli L. TDP-43 in neurodegenerative disorders. Expert Opinion On Biological Therapy. 8: 969-78. PMID 18549326 DOI: 10.1517/14712598.8.7.969  0.386
2008 Dickey CA, Koren J, Zhang YJ, Xu YF, Jinwal UK, Birnbaum MJ, Monks B, Sun M, Cheng JQ, Patterson C, Bailey RM, Dunmore J, Soresh S, Leon C, Morgan D, ... Petrucelli L, et al. Akt and CHIP coregulate tau degradation through coordinated interactions. Proceedings of the National Academy of Sciences of the United States of America. 105: 3622-7. PMID 18292230 DOI: 10.1073/Pnas.0709180105  0.367
2007 Dickey CA, Petrucelli L. Commentary on "Cytoskeletal modulators and pleiotropic strategies for Alzheimer drug discovery." The last stand: the dichotomy of chaperone function in Alzheimer's disease. Alzheimer's & Dementia : the Journal of the Alzheimer's Association. 3: 3-6. PMID 19595909 DOI: 10.1016/J.Jalz.2006.09.001  0.428
2007 Zhang YJ, Xu YF, Dickey CA, Buratti E, Baralle F, Bailey R, Pickering-Brown S, Dickson D, Petrucelli L. Progranulin mediates caspase-dependent cleavage of TAR DNA binding protein-43. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 27: 10530-4. PMID 17898224 DOI: 10.1523/Jneurosci.3421-07.2007  0.399
2007 Dächsel JC, Taylor JP, Mok SS, Ross OA, Hinkle KM, Bailey RM, Hines JH, Szutu J, Madden B, Petrucelli L, Farrer MJ. Identification of potential protein interactors of Lrrk2. Parkinsonism & Related Disorders. 13: 382-5. PMID 17400507 DOI: 10.1016/J.Parkreldis.2007.01.008  0.538
2007 Dickey CA, Kamal A, Lundgren K, Klosak N, Bailey RM, Dunmore J, Ash P, Shoraka S, Zlatkovic J, Eckman CB, Patterson C, Dickson DW, Nahman NS, Hutton M, Burrows F, ... Petrucelli L, et al. The high-affinity HSP90-CHIP complex recognizes and selectively degrades phosphorylated tau client proteins. The Journal of Clinical Investigation. 117: 648-58. PMID 17304350 DOI: 10.1172/Jci29715  0.543
2007 Dickey CA, Patterson C, Dickson D, Petrucelli L. Brain CHIP: removing the culprits in neurodegenerative disease. Trends in Molecular Medicine. 13: 32-8. PMID 17127096 DOI: 10.1016/J.Molmed.2006.11.003  0.405
2006 Dickey CA, Petrucelli L. Current strategies for the treatment of Alzheimer's disease and other tauopathies. Expert Opinion On Therapeutic Targets. 10: 665-76. PMID 16981824 DOI: 10.1517/14728222.10.5.665  0.394
2006 Dickey CA, Ash P, Klosak N, Lee WC, Petrucelli L, Hutton M, Eckman CB. Pharmacologic reductions of total tau levels; implications for the role of microtubule dynamics in regulating tau expression. Molecular Neurodegeneration. 1: 6. PMID 16930453 DOI: 10.1186/1750-1326-1-6  0.565
2006 Dickey CA, Yue M, Lin WL, Dickson DW, Dunmore JH, Lee WC, Zehr C, West G, Cao S, Clark AM, Caldwell GA, Caldwell KA, Eckman C, Patterson C, Hutton M, ... Petrucelli L, et al. Deletion of the ubiquitin ligase CHIP leads to the accumulation, but not the aggregation, of both endogenous phospho- and caspase-3-cleaved tau species. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 26: 6985-96. PMID 16807328 DOI: 10.1523/Jneurosci.0746-06.2006  0.517
2006 Klein RL, Dayton RD, Henderson KM, Petrucelli L. Parkin is protective for substantia nigra dopamine neurons in a tau gene transfer neurodegeneration model. Neuroscience Letters. 401: 130-5. PMID 16554120 DOI: 10.1016/J.Neulet.2006.03.001  0.389
2006 Dickey CA, Dunmore J, Lu B, Wang JW, Lee WC, Kamal A, Burrows F, Eckman C, Hutton M, Petrucelli L. HSP induction mediates selective clearance of tau phosphorylated at proline-directed Ser/Thr sites but not KXGS (MARK) sites. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 20: 753-5. PMID 16464956 DOI: 10.1096/Fj.05-5343Fje  0.471
2006 Dickey CA, Petrucelli L, Hutton M, Eckman CB, Kamal A. P3-319: Manipulating components of the heat shock response as a therapeutic strategy for tauopathies Alzheimer's & Dementia. 2: S468-S469. DOI: 10.1016/J.Jalz.2006.05.1589  0.447
2006 Petrucelli L, Dickey C, Dickson D, Hutton M, Patterson C, Caldwell G. P3-294: The impact of chip on neurodegenerative diseases Alzheimer's & Dementia. 2: S462-S462. DOI: 10.1016/J.Jalz.2006.05.1563  0.493
2005 Dickey CA, Eriksen J, Kamal A, Burrows F, Kasibhatla S, Eckman CB, Hutton M, Petrucelli L. Development of a high throughput drug screening assay for the detection of changes in tau levels -- proof of concept with HSP90 inhibitors. Current Alzheimer Research. 2: 231-8. PMID 15974923 DOI: 10.2174/1567205053585927  0.549
2005 Eriksen JL, Przedborski S, Petrucelli L. Gene dosage and pathogenesis of Parkinson's disease. Trends in Molecular Medicine. 11: 91-6. PMID 15760766 DOI: 10.1016/J.Molmed.2005.01.001  0.335
2004 Petrucelli L, Dickson D, Kehoe K, Taylor J, Snyder H, Grover A, De Lucia M, McGowan E, Lewis J, Prihar G, Kim J, Dillmann WH, Browne SE, Hall A, Voellmy R, et al. CHIP and Hsp70 regulate tau ubiquitination, degradation and aggregation. Human Molecular Genetics. 13: 703-14. PMID 14962978 DOI: 10.1093/Hmg/Ddh083  0.71
2004 Eriksen J, Kehoe K, Taylor J, Hutton M, Petrucelli L. P3-389 HSP70 prevents α-synuclein inhibition of the proteasome Neurobiology of Aging. 25: S466. DOI: 10.1016/S0197-4580(04)81537-9  0.454
2004 Taylor JP, Petrucelli L, Kehoe K, Hutton M. P3-277 The role of molecular chaperones in the metabolism of tau Neurobiology of Aging. 25: S433. DOI: 10.1016/S0197-4580(04)81427-1  0.476
2004 Kehoe K, Taylor J, Voellmy R, Petrucelli L, Hutton M. P3-242 Induction of the heat shock response protects against tau associated toxicity in M17 cell lines Neurobiology of Aging. 25: S423-S424. DOI: 10.1016/S0197-4580(04)81392-7  0.467
2004 Petrucelli L, Taylor J, Kehoe K, Lewis J, McGowan E, Snyder H, Wolozin B, Dawson TM, Dillmann W, Voellmy R, Hutton M. P3-228 Chip and HSP70 regulate tau ubiquitination, degradation and aggregation Neurobiology of Aging. 25: S419-S420. DOI: 10.1016/S0197-4580(04)81378-2  0.639
2004 Eriksen JL, Petrucelli L. Parkinson's disease - Molecular mechanisms of disease Drug Discovery Today: Disease Mechanisms. 1: 399-405. DOI: 10.1016/J.Ddmec.2004.11.016  0.36
2003 Eriksen JL, Dawson TM, Dickson DW, Petrucelli L. Caught in the act: alpha-synuclein is the culprit in Parkinson's disease. Neuron. 40: 453-6. PMID 14642269 DOI: 10.1016/S0896-6273(03)00684-6  0.339
2003 Choi P, Snyder H, Petrucelli L, Theisler C, Chong M, Zhang Y, Lim K, Chung KK, Kehoe K, D'Adamio L, Lee JM, Cochran E, Bowser R, Dawson TM, Wolozin B. SEPT5_v2 is a parkin-binding protein. Brain Research. Molecular Brain Research. 117: 179-89. PMID 14559152 DOI: 10.1016/S0169-328X(03)00318-8  0.325
2002 Petrucelli L, O'Farrell C, Lockhart PJ, Baptista M, Kehoe K, Vink L, Choi P, Wolozin B, Farrer M, Hardy J, Cookson MR. Parkin protects against the toxicity associated with mutant alpha-synuclein: proteasome dysfunction selectively affects catecholaminergic neurons. Neuron. 36: 1007-19. PMID 12495618 DOI: 10.1016/S0896-6273(02)01125-X  0.666
2001 O'Farrell C, Murphy DD, Petrucelli L, Singleton AB, Hussey J, Farrer M, Hardy J, Dickson DW, Cookson MR. Transfected synphilin-1 forms cytoplasmic inclusions in HEK293 cells. Brain Research. Molecular Brain Research. 97: 94-102. PMID 11744167 DOI: 10.1016/S0169-328X(01)00292-3  0.708
2001 Choi P, Golts N, Snyder H, Chong M, Petrucelli L, Hardy J, Sparkman D, Cochran E, Lee JM, Wolozin B. Co-association of parkin and alpha-synuclein. Neuroreport. 12: 2839-43. PMID 11588587 DOI: 10.1097/00001756-200109170-00017  0.405
2001 Farrer M, Chan P, Chen R, Tan L, Lincoln S, Hernandez D, Forno L, Gwinn-Hardy K, Petrucelli L, Hussey J, Singleton A, Tanner C, Hardy J, Langston JW. Lewy bodies and parkinsonism in families with parkin mutations. Annals of Neurology. 50: 293-300. PMID 11558785 DOI: 10.1002/Ana.1132  0.621
2001 West A, Farrer M, Petrucelli L, Cookson M, Lockhart P, Hardy J. Identification and characterization of the human parkin gene promoter. Journal of Neurochemistry. 78: 1146-52. PMID 11553688 DOI: 10.1046/J.1471-4159.2001.00512.X  0.599
2000 Ostrerova-Golts N, Petrucelli L, Hardy J, Lee JM, Farer M, Wolozin B. The A53T α-Synuclein Mutation Increases Iron-Dependent Aggregation and Toxicity The Journal of Neuroscience. 20: 6048-6054. DOI: 10.1523/Jneurosci.20-16-06048.2000  0.414
1999 Ostrerova N, Petrucelli L, Farrer M, Mehta N, Choi P, Hardy J, Wolozin B. α-Synuclein Shares Physical and Functional Homology with 14-3-3 Proteins The Journal of Neuroscience. 19: 5782-5791. DOI: 10.1523/Jneurosci.19-14-05782.1999  0.551
Show low-probability matches.