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Leonard Petrucelli, PhD - Publications

Affiliations: 
Neuroscience Research Mayo Clinic Jacksonville, Jacksonville, FL, United States 
Area:
http://www.biomedexperts.com/Profile.bme/1110907/Leonard_Petrucelli
Website:
http://mayoresearch.mayo.edu/mayo/research/staff/petrucelli_l.cfm

257 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2021 Pottier C, Mateiu L, Baker MC, DeJesus-Hernandez M, Teixeira Vicente C, Finch NA, Tian S, van Blitterswijk M, Murray ME, Ren Y, Petrucelli L, Oskarsson B, Biernacka JM, Graff-Radford NR, Boeve BF, et al. Shared brain transcriptomic signature in TDP-43 type A FTLD patients with or without GRN mutations. Brain : a Journal of Neurology. PMID 34918030 DOI: 10.1093/brain/awab437  1
2021 Arakhamia T, Lee CE, Carlomagno Y, Kumar M, Duong DM, Wesseling H, Kundinger SR, Wang K, Williams D, DeTure M, Dickson DW, Cook CN, Seyfried NT, Petrucelli L, Steen JA, et al. Posttranslational Modifications Mediate the Structural Diversity of Tauopathy Strains. Cell. 184: 6207-6210. PMID 34890553 DOI: 10.1016/j.cell.2021.11.029  1
2021 Bush JA, Aikawa H, Fuerst R, Li Y, Ursu A, Meyer SM, Benhamou RI, Chen JL, Khan T, Wagner-Griffin S, Van Meter MJ, Tong Y, Olafson H, McKee KK, Childs-Disney JL, ... ... Petrucelli L, et al. Ribonuclease recruitment using a small molecule reduced c9ALS/FTD r(GC) repeat expansion in vitro and in vivo ALS models. Science Translational Medicine. 13: eabd5991. PMID 34705518 DOI: 10.1126/scitranslmed.abd5991  1
2021 Ursu A, Baisden JT, Bush JA, Taghavi A, Choudhary S, Zhang YJ, Gendron TF, Petrucelli L, Yildirim I, Disney MD. A Small Molecule Exploits Hidden Structural Features within the RNA Repeat Expansion That Causes c9ALS/FTD and Rescues Pathological Hallmarks. Acs Chemical Neuroscience. 12: 4076-4089. PMID 34677935 DOI: 10.1021/acschemneuro.1c00470  1
2021 Jiang L, Lin W, Zhang C, Ash PEA, Verma M, Kwan J, van Vliet E, Yang Z, Cruz AL, Boudeau S, Maziuk BF, Lei S, Song J, Alvarez VE, Hovde S, ... ... Petrucelli L, et al. Interaction of tau with HNRNPA2B1 and N-methyladenosine RNA mediates the progression of tauopathy. Molecular Cell. PMID 34453888 DOI: 10.1016/j.molcel.2021.07.038  1
2021 Wu Y, Shao W, Todd TW, Tong J, Yue M, Koga S, Castanedes-Casey M, Librero AL, Lee CW, Mackenzie IR, Dickson DW, Zhang YJ, Petrucelli L, Prudencio M. Microglial lysosome dysfunction contributes to white matter pathology and TDP-43 proteinopathy in GRN-associated FTD. Cell Reports. 36: 109581. PMID 34433069 DOI: 10.1016/j.celrep.2021.109581  1
2021 Chung DC, Roemer S, Petrucelli L, Dickson DW. Cellular and pathological heterogeneity of primary tauopathies. Molecular Neurodegeneration. 16: 57. PMID 34425874 DOI: 10.1186/s13024-021-00476-x  1
2021 Koike Y, Jansen-West KR, Hanna Al-Shaikh R, Carlomagno Y, Song Y, Dunmore JA, LeDoux MS, Friedman JH, Pena AB, Uitti RJ, Zaremba J, van Gerpen JA, Pfeiffer RF, Veerappan V, Aiba I, ... ... Petrucelli L, et al. Urine levels of the polyglutamine ataxin-3 protein are elevated in patients with spinocerebellar ataxia type 3. Parkinsonism & Related Disorders. 89: 151-154. PMID 34303201 DOI: 10.1016/j.parkreldis.2021.07.018  1
2021 ReFaey K, Freeman WD, Tripathi S, Guerrero-Cazares H, Eatz TA, Meschia JF, Carter RE, Petrucelli L, Meyer FB, Quinones-Hinojosa A. NIH funding trends for neurosurgeon-scientists from 1993-2017: Biomedical workforce implications for neurooncology. Journal of Neuro-Oncology. PMID 34232472 DOI: 10.1007/s11060-021-03797-5  0.01
2021 ReFaey K, Freeman WD, Tripathi S, Guerrero-Cazares H, Eatz TA, Meschia JF, Carter RE, Petrucelli L, Meyer FB, Quinones-Hinojosa A. NIH funding trends for neurosurgeon-scientists from 1993-2017: Biomedical workforce implications for neurooncology. Journal of Neuro-Oncology. PMID 34232472 DOI: 10.1007/s11060-021-03797-5  0.01
2021 Prudencio M, Erben Y, Marquez CP, Jansen-West KR, Franco-Mesa C, Heckman MG, White LJ, Dunmore JA, Cook CN, Lilley MT, Song Y, Harlow CF, Oskarsson B, Nicholson KA, Wszolek ZK, ... ... Petrucelli L, et al. Serum neurofilament light protein correlates with unfavorable clinical outcomes in hospitalized patients with COVID-19. Science Translational Medicine. PMID 34131052 DOI: 10.1126/scitranslmed.abi7643  1
2021 Melnick M, Gonzales P, LaRocca TJ, Song Y, Wuu J, Benatar M, Oskarsson B, Petrucelli L, Dowell RD, Link CD, Prudencio M. Application of a bioinformatic pipeline to RNA-seq data identifies novel viruslike sequence in human blood. G3 (Bethesda, Md.). PMID 33914880 DOI: 10.1093/g3journal/jkab141  1
2021 DeJesus-Hernandez M, Aleff RA, Jackson JL, Finch NA, Baker MC, Gendron TF, Murray ME, McLaughlin IJ, Harting JR, Graff-Radford NR, Oskarsson B, Knopman DS, Josephs KA, Boeve BF, Petersen RC, ... ... Petrucelli L, et al. Long-read targeted sequencing uncovers clinicopathological associations for C9orf72-linked diseases. Brain : a Journal of Neurology. PMID 33889947 DOI: 10.1093/brain/awab006  1
2021 Erben Y, Franco-Mesa C, Gloviczki P, Stone W, Quinones-Hinojosa A, Meltzer AJ, Lin M, Greenway MRF, Hamid O, Devcic Z, Toskich B, Ritchie C, Lamb CJ, De Martino RR, Siegel J, ... ... Petrucelli L, et al. Deep Venous Thrombosis and Pulmonary Embolism Among Hospitalized Coronavirus Disease 2019 (COVID-19) Positive Patients Predict Higher Mortality, Prolonged Intensive Care Unit and Hospital Stays in A Multi-Site Healthcare System. Journal of Vascular Surgery. Venous and Lymphatic Disorders. PMID 33836287 DOI: 10.1016/j.jvsv.2021.03.009  1
2021 Rojas JC, Wang P, Staffaroni AM, Heller C, Cobigo Y, Wolf A, Goh SM, Ljubenkov PA, Heuer HW, Fong JC, Taylor JB, Veras E, Song L, Jeromin A, Hanlon D, ... ... Petrucelli L, et al. Plasma Neurofilament Light for Prediction of Disease Progression in Familial Frontotemporal Lobar Degeneration. Neurology. PMID 33827960 DOI: 10.1212/WNL.0000000000011848  1
2021 Carlomagno Y, Manne S, DeTure M, Prudencio M, Zhang YJ, Hanna Al-Shaikh R, Dunmore JA, Daughrity LM, Song Y, Castanedes-Casey M, Lewis-Tuffin LJ, Nicholson KA, Wszolek ZK, Dickson DW, Fitzpatrick AWP, ... Petrucelli L, et al. The AD tau core spontaneously self-assembles and recruits full-length tau to filaments. Cell Reports. 34: 108843. PMID 33730588 DOI: 10.1016/j.celrep.2021.108843  1
2021 Ash PEA, Lei S, Shattuck J, Boudeau S, Carlomagno Y, Medalla M, Mashimo BL, Socorro G, Al-Mohanna LFA, Jiang L, Öztürk MM, Knobel M, Ivanov P, Petrucelli L, Wegmann S, et al. TIA1 potentiates tau phase separation and promotes generation of toxic oligomeric tau. Proceedings of the National Academy of Sciences of the United States of America. 118. PMID 33619090 DOI: 10.1073/pnas.2014188118  1
2021 Maor-Nof M, Shipony Z, Lopez-Gonzalez R, Nakayama L, Zhang YJ, Couthouis J, Blum JA, Castruita PA, Linares GR, Ruan K, Ramaswami G, Simon DJ, Nof A, Santana M, Han K, ... ... Petrucelli L, et al. p53 is a central regulator driving neurodegeneration caused by C9orf72 poly(PR). Cell. PMID 33482083 DOI: 10.1016/j.cell.2020.12.025  1
2020 Wojtas AM, Carlomagno Y, Sens JP, Kang SS, Jensen TD, Kurti A, Baker KE, Berry TJ, Phillips VR, Castanedes MC, Awan A, DeTure M, De Castro CHF, Librero AL, Yue M, ... ... Petrucelli L, et al. Clusterin ameliorates tau pathology in vivo by inhibiting fibril formation. Acta Neuropathologica Communications. 8: 210. PMID 33261653 DOI: 10.1186/s40478-020-01079-1  1
2020 Wojtas AM, Sens JP, Kang SS, Baker KE, Berry TJ, Kurti A, Daughrity L, Jansen-West KR, Dickson DW, Petrucelli L, Bu G, Liu CC, Fryer JD. Astrocyte-derived clusterin suppresses amyloid formation in vivo. Molecular Neurodegeneration. 15: 71. PMID 33246484 DOI: 10.1186/s13024-020-00416-1  1
2020 Ursu A, Wang KW, Bush JA, Choudhary S, Chen JL, Baisden JT, Zhang YJ, Gendron TF, Petrucelli L, Yildirim I, Disney MD. Structural Features of Small Molecules Targeting the RNA Repeat Expansion That Causes Genetically Defined ALS/FTD. Acs Chemical Biology. PMID 33196168 DOI: 10.1021/acschembio.0c00049  1
2020 Gendron TF, Badi MK, Heckman MG, Jansen-West KR, Vilanilam GK, Johnson PW, Burch AR, Walton RL, Ross OA, Brott TG, Miller TM, Berry JD, Nicholson KA, Wszolek ZK, Oskarsson BE, ... ... Petrucelli L, et al. Plasma neurofilament light predicts mortality in patients with stroke. Science Translational Medicine. 12. PMID 33177179 DOI: 10.1126/scitranslmed.aay1913  1
2020 Josephs KA, Martin PR, Weigand SD, Tosakulwong N, Buciuc M, Murray ME, Petrucelli L, Senjem ML, Spychalla AJ, Knopman DS, Boeve BF, Petersen RC, Parisi JE, Dickson DW, Jack CR, et al. Protein contributions to brain atrophy acceleration in Alzheimer's disease and primary age-related tauopathy. Brain : a Journal of Neurology. PMID 33150361 DOI: 10.1093/brain/awaa299  1
2020 Hou X, Watzlawik JO, Cook C, Liu CC, Kang SS, Lin WL, DeTure M, Heckman MG, Diehl NN, Al-Shaikh FSH, Walton RL, Ross OA, Melrose HL, Ertekin-Taner N, Bu G, ... Petrucelli L, et al. Mitophagy alterations in Alzheimer's disease are associated with granulovacuolar degeneration and early tau pathology. Alzheimer's & Dementia : the Journal of the Alzheimer's Association. PMID 33090691 DOI: 10.1002/alz.12198  1
2020 Prudencio M, Garcia-Moreno H, Jansen-West KR, Al-Shaikh RH, Gendron TF, Heckman MG, Spiegel MR, Carlomagno Y, Daughrity LM, Song Y, Dunmore JA, Byron N, Oskarsson B, Nicholson KA, Staff NP, ... ... Petrucelli L, et al. Toward allele-specific targeting therapy and pharmacodynamic marker for spinocerebellar ataxia type 3. Science Translational Medicine. 12. PMID 33087504 DOI: 10.1126/scitranslmed.abb7086  1
2020 Lee YB, Baskaran P, Gomez-Deza J, Chen HJ, Nishimura AL, Smith BN, Troakes C, Adachi Y, Stepto A, Petrucelli L, Gallo JM, Hirth F, Rogelj B, Guthrie S, Shaw CE. C9orf72 poly GA RAN-translated protein plays a key role in amyotrophic lateral sclerosis via aggregation and toxicity. Human Molecular Genetics. PMID 32888026 DOI: 10.1093/hmg/ddaa181  1
2020 Cook CN, Wu Y, Odeh HM, Gendron TF, Jansen-West K, Del Rosso G, Yue M, Jiang P, Gomes E, Tong J, Daughrity LM, Avendano NM, Castanedes-Casey M, Shao W, Oskarsson B, ... ... Petrucelli L, et al. poly(GR) aggregation induces TDP-43 proteinopathy. Science Translational Medicine. 12. PMID 32878979 DOI: 10.1126/Scitranslmed.Abb3774  1
2020 Prudencio M, Humphrey J, Pickles S, Brown AL, Hill SE, Kachergus J, Shi J, Heckman M, Spiegel M, Cook C, Song Y, Yue M, Daughrity L, Carlomagno Y, Jansen-West K, ... ... Petrucelli L, et al. Truncated stathmin-2 is a marker of TDP-43 pathology in frontotemporal dementia. The Journal of Clinical Investigation. PMID 32790644 DOI: 10.1172/Jci139741  1
2020 Buciuc M, Botha H, Murray ME, Schwarz CG, Senjem ML, Jones DT, Knopman DS, Boeve BF, Petersen RC, Jack CR, Petrucelli L, Parisi JE, Dickson DW, Lowe V, Whitwell JL, et al. Utility of FDG-PET in diagnosis of Alzheimer-related TDP-43 proteinopathy. Neurology. PMID 32518145 DOI: 10.1212/Wnl.0000000000009722  1
2020 McEachin ZT, Gendron TF, Raj N, García-Murias M, Banerjee A, Purcell RH, Ward PJ, Todd TW, Merritt-Garza ME, Jansen-West K, Hales CM, García-Sobrino T, Quintáns B, Holler CJ, Taylor G, ... ... Petrucelli L, et al. Chimeric Peptide Species Contribute to Divergent Dipeptide Repeat Pathology in c9ALS/FTD and SCA36. Neuron. PMID 32375063 DOI: 10.1016/J.Neuron.2020.04.011  1
2020 Todd TW, McEachin ZT, Chew J, Burch AR, Jansen-West K, Tong J, Yue M, Song Y, Castanedes-Casey M, Kurti A, Dunmore JH, Fryer JD, Zhang YJ, San Millan B, Teijeira Bautista S, ... ... Petrucelli L, et al. Hexanucleotide Repeat Expansions in c9FTD/ALS and SCA36 Confer Selective Patterns of Neurodegeneration In Vivo. Cell Reports. 31: 107616. PMID 32375043 DOI: 10.1016/J.Celrep.2020.107616  1
2020 Zhu Q, Jiang J, Gendron TF, McAlonis-Downes M, Jiang L, Taylor A, Diaz Garcia S, Ghosh Dastidar S, Rodriguez MJ, King P, Zhang Y, La Spada AR, Xu H, Petrucelli L, Ravits J, et al. Reduced C9ORF72 function exacerbates gain of toxicity from ALS/FTD-causing repeat expansion in C9orf72. Nature Neuroscience. PMID 32284607 DOI: 10.1038/S41593-020-0619-5  1
2020 Frew J, Baradaran-Heravi A, Balgi AD, Wu X, Yan TD, Arns S, Shidmoossavee FS, Tan J, Jaquith JB, Jansen-West KR, Lynn FC, Gao FB, Petrucelli L, Feldman HH, Mackenzie IR, et al. Premature termination codon readthrough upregulates progranulin expression and improves lysosomal function in preclinical models of GRN deficiency. Molecular Neurodegeneration. 15: 21. PMID 32178712 DOI: 10.1186/S13024-020-00369-5  1
2020 Arakhamia T, Lee CE, Carlomagno Y, Duong DM, Kundinger SR, Wang K, Williams D, DeTure M, Dickson DW, Cook CN, Seyfried NT, Petrucelli L, Fitzpatrick AWP. Posttranslational Modifications Mediate the Structural Diversity of Tauopathy Strains. Cell. PMID 32032505 DOI: 10.1016/J.Cell.2020.01.027  1
2020 Jackson JL, Finch NA, Baker MC, Kachergus JM, DeJesus-Hernandez M, Pereira K, Christopher E, Prudencio M, Heckman MG, Thompson EA, Dickson DW, Shah J, Oskarsson B, Petrucelli L, Rademakers R, et al. Elevated methylation levels, reduced expression levels, and frequent contractions in a clinical cohort of C9orf72 expansion carriers. Molecular Neurodegeneration. 15: 7. PMID 32000838 DOI: 10.1186/S13024-020-0359-8  1
2020 Cook C, Petrucelli L. Aβ Puts the Alpha in Synuclein. Neuron. 105: 205-206. PMID 31972141 DOI: 10.1016/J.Neuron.2020.01.001  1
2020 Vu L, An J, Kovalik T, Gendron T, Petrucelli L, Bowser R. Cross-sectional and longitudinal measures of chitinase proteins in amyotrophic lateral sclerosis and expression of CHI3L1 in activated astrocytes. Journal of Neurology, Neurosurgery, and Psychiatry. PMID 31937582 DOI: 10.1136/Jnnp-2019-321916  0.01
2020 Heuer HW, Wang P, Rascovsky K, Wolf A, Appleby B, Bove J, Bordelon Y, Brannelly P, Brushaber DE, Caso C, Coppola G, Dickerson B, Dickinson S, Domoto-Reilly K, Faber K, ... ... Petrucelli L, et al. Comparison of sporadic and familial behavioral variant frontotemporal dementia (FTD) in a North American cohort. Alzheimer's & Dementia : the Journal of the Alzheimer's Association. 16: 60-70. PMID 31914226 DOI: 10.1002/Alz.12046  1
2020 Miyagawa T, Brushaber D, Syrjanen J, Kremers W, Fields J, Forsberg LK, Heuer HW, Knopman D, Kornak J, Boxer A, Rosen HJ, Boeve BF, Appleby B, Bordelon Y, Bove J, ... ... Petrucelli L, et al. Utility of the global CDR plus NACC FTLD rating and development of scoring rules: Data from the ARTFL/LEFFTDS Consortium. Alzheimer's & Dementia : the Journal of the Alzheimer's Association. 16: 106-117. PMID 31914218 DOI: 10.1002/Alz.12033  1
2019 Dickson DW, Baker MC, Jackson JL, DeJesus-Hernandez M, Finch NA, Tian S, Heckman MG, Pottier C, Gendron TF, Murray ME, Ren Y, Reddy JS, Graff-Radford NR, Boeve BF, Petersen RC, ... ... Petrucelli L, et al. Extensive transcriptomic study emphasizes importance of vesicular transport in C9orf72 expansion carriers. Acta Neuropathologica Communications. 7: 150. PMID 31594549 DOI: 10.1186/S40478-019-0797-0  1
2019 Chen Q, Boeve BF, Schwarz CG, Reid R, Tosakulwong N, Lesnick TG, Bove J, Brannelly P, Brushaber D, Coppola G, Dheel C, Dickerson BC, Dickinson S, Faber K, Fields J, ... ... Petrucelli L, et al. Tracking white matter degeneration in asymptomatic and symptomatic MAPT mutation carriers. Neurobiology of Aging. 83: 54-62. PMID 31585367 DOI: 10.1016/J.Neurobiolaging.2019.08.011  1
2019 Moore S, Alsop E, Lorenzini I, Starr A, Rabichow BE, Mendez E, Levy JL, Burciu C, Reiman R, Chew J, Belzil VV, Dickson D, Robertson J, Staats KA, Ichida JK, ... Petrucelli L, et al. Correction to: ADAR2 mislocalization and widespread RNA editing aberrations in C9orf72-mediated ALS/FTD. Acta Neuropathologica. PMID 31559488 DOI: 10.1007/S00401-019-02076-Y  1
2019 Sakae N, Roemer SF, Bieniek KF, Murray ME, Baker MC, Kasanuki K, Graff-Radford NR, Petrucelli L, Van Blitterswijk M, Rademakers R, Dickson DW. Microglia in frontotemporal lobar degeneration with progranulin or C9ORF72 mutations. Annals of Clinical and Translational Neurology. PMID 31448566 DOI: 10.1002/Acn3.50875  1
2019 Yamada SB, Gendron TF, Niccoli T, Genuth NR, Grosely R, Shi Y, Glaria I, Kramer NJ, Nakayama L, Fang S, Dinger TJI, Thoeng A, Rocha G, Barna M, Puglisi JD, ... ... Petrucelli L, et al. RPS25 is required for efficient RAN translation of C9orf72 and other neurodegenerative disease-associated nucleotide repeats. Nature Neuroscience. PMID 31358992 DOI: 10.1038/S41593-019-0455-7  1
2019 Josephs KA, Zhang YJ, Baker M, Rademakers R, Petrucelli L, Dickson DW. C-terminal and full length TDP-43 specie differ according to FTLD-TDP lesion type but not genetic mutation. Acta Neuropathologica Communications. 7: 100. PMID 31266542 DOI: 10.1186/S40478-019-0755-X  1
2019 Goodman LD, Prudencio M, Kramer NJ, Martinez-Ramirez LF, Srinivasan AR, Lan M, Parisi MJ, Zhu Y, Chew J, Cook CN, Berson A, Gitler AD, Petrucelli L, Bonini NM. Toxic expanded GGGGCC repeat transcription is mediated by the PAF1 complex in C9orf72-associated FTD. Nature Neuroscience. PMID 31110321 DOI: 10.1038/S41593-019-0396-1  1
2019 Goodman LD, Prudencio M, Srinivasan AR, Rifai OM, Lee VM, Petrucelli L, Bonini NM. eIF4B and eIF4H mediate GR production from expanded G4C2 in a Drosophila model for C9orf72-associated ALS. Acta Neuropathologica Communications. 7: 62. PMID 31023341 DOI: 10.1186/S40478-019-0711-9  1
2019 Moore S, Alsop E, Lorenzini I, Starr A, Rabichow BE, Mendez E, Levy JL, Burciu C, Reiman R, Chew J, Belzil VV, W Dickson D, Robertson J, Staats KA, Ichida JK, ... Petrucelli L, et al. ADAR2 mislocalization and widespread RNA editing aberrations in C9orf72-mediated ALS/FTD. Acta Neuropathologica. PMID 30945056 DOI: 10.1007/S00401-019-01999-W  1
2019 Cook C, Petrucelli L. Genetic Convergence Brings Clarity to the Enigmatic Red Line in ALS. Neuron. 101: 1057-1069. PMID 30897357 DOI: 10.1016/J.Neuron.2019.02.032  1
2019 Chung DC, Carlomagno Y, Cook CN, Jansen-West K, Daughrity L, Lewis-Tuffin LJ, Castanedes-Casey M, DeTure M, Dickson DW, Petrucelli L. Tau exhibits unique seeding properties in globular glial tauopathy. Acta Neuropathologica Communications. 7: 36. PMID 30845985 DOI: 10.1186/S40478-019-0691-9  1
2019 Wennberg AM, Whitwell JL, Tosakulwong N, Weigand SD, Murray ME, Machulda MM, Petrucelli L, Mielke MM, Jack CR, Knopman DS, Parisi JE, Petersen RC, Dickson DW, Josephs KA. The influence of tau, amyloid, alpha-synuclein, TDP-43, and vascular pathology in clinically normal elderly individuals. Neurobiology of Aging. 77: 26-36. PMID 30776649 DOI: 10.1016/J.Neurobiolaging.2019.01.008  1
2019 Chew J, Cook C, Gendron TF, Jansen-West K, Del Rosso G, Daughrity LM, Castanedes-Casey M, Kurti A, Stankowski JN, Disney MD, Rothstein JD, Dickson DW, Fryer JD, Zhang YJ, Petrucelli L. Aberrant deposition of stress granule-resident proteins linked to C9orf72-associated TDP-43 proteinopathy. Molecular Neurodegeneration. 14: 9. PMID 30767771 DOI: 10.1186/S13024-019-0310-Z  1
2019 Zhang YJ, Guo L, Gonzales PK, Gendron TF, Wu Y, Jansen-West K, O'Raw AD, Pickles SR, Prudencio M, Carlomagno Y, Gachechiladze MA, Ludwig C, Tian R, Chew J, DeTure M, ... ... Petrucelli L, et al. Heterochromatin anomalies and double-stranded RNA accumulation underlie poly(PR) toxicity. Science (New York, N.Y.). 363. PMID 30765536 DOI: 10.1126/Science.Aav2606  1
2019 Pottier C, Ren Y, Perkerson RB, Baker M, Jenkins GD, van Blitterswijk M, DeJesus-Hernandez M, van Rooij JGJ, Murray ME, Christopher E, McDonnell SK, Fogarty Z, Batzler A, Tian S, Vicente CT, ... ... Petrucelli L, et al. Genome-wide analyses as part of the international FTLD-TDP whole-genome sequencing consortium reveals novel disease risk factors and increases support for immune dysfunction in FTLD. Acta Neuropathologica. PMID 30739198 DOI: 10.1007/S00401-019-01962-9  1
2019 Carlomagno Y, Chung DC, Yue M, Kurti A, Avendano NM, Castanedes-Casey M, Hinkle KM, Jansen-West K, Daughrity LM, Tong J, Phillips V, Rademakers R, DeTure M, Fryer JD, Dickson DW, ... Petrucelli L, et al. Enhanced phosphorylation of T153 in soluble tau is a defining biochemical feature of the A152T tau risk variant. Acta Neuropathologica Communications. 7: 10. PMID 30674342 DOI: 10.1186/S40478-019-0661-2  1
2019 Eftekharzadeh B, Daigle JG, Kapinos LE, Coyne A, Schiantarelli J, Carlomagno Y, Cook C, Miller SJ, Dujardin S, Amaral AS, Grima JC, Bennett RE, Tepper K, DeTure M, Vanderburg CR, ... ... Petrucelli L, et al. Tau Protein Disrupts Nucleocytoplasmic Transport in Alzheimer's Disease. Neuron. 101: 349. PMID 30653936 DOI: 10.1016/J.Neuron.2018.12.031  1
2019 Josephs KA, Murray ME, Tosakulwong N, Weigand SD, Serie AM, Perkerson RB, Matchett BJ, Jack CR, Knopman DS, Petersen RC, Parisi JE, Petrucelli L, Baker M, Rademakers R, Whitwell JL, et al. Pathological, imaging and genetic characteristics support the existence of distinct TDP-43 types in non-FTLD brains. Acta Neuropathologica. PMID 30604226 DOI: 10.1007/S00401-018-1951-7  1
2019 Heuer HW, Boxer AL, Boeve BF, Rosen HJ, Forsberg LK, Brushaber D, Appleby B, Bordelon YM, Brannelly P, Coppola G, Dickerson BC, Dickinson S, Kimiko D, Faber K, Fields JA, ... ... Petrucelli L, et al. O4-03-01: Frontotemporal Lobar Degeneration Research In North America: Progress In The Artfl/Lefftds Consortia Alzheimers & Dementia. 15. DOI: 10.1016/J.Jalz.2019.06.4752  1
2019 Chen Q, Boeve BF, Schwarz CG, Reid RI, Tosakulwong N, Lesnick TG, Bove J, Brannelly P, Brushaber D, Coppola G, Dheel C, Dickerson BC, Dickinson S, Faber K, Fields JA, ... ... Petrucelli L, et al. P2-329: Tracking White Matter Degeneration In Asymptomatic And Symptomatic Mapt Mutation Carriers With Dti Alzheimers & Dementia. 15. DOI: 10.1016/J.Jalz.2019.06.2736  1
2018 Wang ZF, Ursu A, Childs-Disney JL, Guertler R, Yang WY, Bernat V, Rzuczek SG, Fuerst R, Zhang YJ, Gendron TF, Yildirim I, Dwyer BG, Rice JE, Petrucelli L, Disney MD. The Hairpin Form of r(GC) in c9ALS/FTD Is Repeat-Associated Non-ATG Translated and a Target for Bioactive Small Molecules. Cell Chemical Biology. PMID 30503283 DOI: 10.1016/J.Chembiol.2018.10.018  1
2018 Jiang L, Ash PEA, Maziuk BF, Ballance HI, Boudeau S, Abdullatif AA, Orlando M, Petrucelli L, Ikezu T, Wolozin B. TIA1 regulates the generation and response to toxic tau oligomers. Acta Neuropathologica. PMID 30465259 DOI: 10.1007/S00401-018-1937-5  1
2018 Wennberg AM, Tosakulwong N, Lesnick TG, Murray ME, Whitwell JL, Liesinger AM, Petrucelli L, Boeve BF, Parisi JE, Knopman DS, Petersen RC, Dickson DW, Josephs KA. Association of Apolipoprotein E ε4 With Transactive Response DNA-Binding Protein 43. Jama Neurology. 75: 1347-1354. PMID 30422173 DOI: 10.1001/Jamaneurol.2018.3139  1
2018 Zhao N, Liu CC, Van Ingelgom AJ, Linares C, Kurti A, Knight JA, Heckman MG, Diehl NN, Shinohara M, Martens YA, Attrebi ON, Petrucelli L, Fryer JD, Wszolek ZK, Graff-Radford NR, et al. APOE ε2 is associated with increased tau pathology in primary tauopathy. Nature Communications. 9: 4388. PMID 30348994 DOI: 10.1038/S41467-018-06783-0  1
2018 Hanna Al Shaikh R, Caulfield T, Strongosky AJ, Matthew M, Jansen-West KR, Prudencio M, Fryer JD, Petrucelli L, Uitti RJ, Wszolek ZK. TRIO gene segregation in a family with cerebellar ataxia. Neurologia I Neurochirurgia Polska. PMID 30279051 DOI: 10.1016/J.Pjnns.2018.09.006  1
2018 Gan L, Cookson MR, Petrucelli L, La Spada AR. Converging pathways in neurodegeneration, from genetics to mechanisms. Nature Neuroscience. 21: 1300-1309. PMID 30258237 DOI: 10.1038/S41593-018-0237-7  1
2018 Eftekharzadeh B, Daigle JG, Kapinos LE, Coyne A, Schiantarelli J, Carlomagno Y, Cook C, Miller SJ, Dujardin S, Amaral AS, Grima JC, Bennett RE, Tepper K, DeTure M, Vanderburgh CR, ... ... Petrucelli L, et al. Tau Protein Disrupts Nucleocytoplasmic Transport in Alzheimer's Disease. Neuron. 99: 925-940.e7. PMID 30189209 DOI: 10.1016/J.Neuron.2018.07.039  1
2018 Ebbert MTW, Farrugia SL, Sens JP, Jansen-West K, Gendron TF, Prudencio M, McLaughlin IJ, Bowman B, Seetin M, DeJesus-Hernandez M, Jackson J, Brown PH, Dickson DW, van Blitterswijk M, Rademakers R, ... Petrucelli L, et al. Long-read sequencing across the C9orf72 'GGGGCC' repeat expansion: implications for clinical use and genetic discovery efforts in human disease. Molecular Neurodegeneration. 13: 46. PMID 30126445 DOI: 10.1186/S13024-018-0274-4  1
2018 Kang SS, Ebbert MTW, Baker KE, Cook C, Wang X, Sens JP, Kocher JP, Petrucelli L, Fryer JD. Microglial translational profiling reveals a convergent APOE pathway from aging, amyloid, and tau. The Journal of Experimental Medicine. PMID 30082275 DOI: 10.1084/Jem.20180653  1
2018 Sakae N, Bieniek KF, Zhang YJ, Ross K, Gendron TF, Murray ME, Rademakers R, Petrucelli L, Dickson DW. Poly-GR dipeptide repeat polymers correlate with neurodegeneration and Clinicopathological subtypes in C9ORF72-related brain disease. Acta Neuropathologica Communications. 6: 63. PMID 30029693 DOI: 10.1186/S40478-018-0564-7  1
2018 Sanchez-Contreras MY, Kouri N, Cook CN, Serie DJ, Heckman MG, Finch NA, Caselli RJ, Uitti RJ, Wszolek ZK, Graff-Radford N, Petrucelli L, Wang LS, Schellenberg GD, Dickson DW, Rademakers R, et al. Replication of progressive supranuclear palsy genome-wide association study identifies SLCO1A2 and DUSP10 as new susceptibility loci. Molecular Neurodegeneration. 13: 37. PMID 29986742 DOI: 10.1186/S13024-018-0267-3  1
2018 Mordes DA, Prudencio M, Goodman LD, Klim JR, Moccia R, Limone F, Pietilainen O, Chowdhary K, Dickson DW, Rademakers R, Bonini NM, Petrucelli L, Eggan K. Dipeptide repeat proteins activate a heat shock response found in C9ORF72-ALS/FTLD patients. Acta Neuropathologica Communications. 6: 55. PMID 29973287 DOI: 10.1186/S40478-018-0555-8  1
2018 Zhang YJ, Gendron TF, Ebbert MTW, O'Raw AD, Yue M, Jansen-West K, Zhang X, Prudencio M, Chew J, Cook CN, Daughrity LM, Tong J, Song Y, Pickles SR, Castanedes-Casey M, ... ... Petrucelli L, et al. Poly(GR) impairs protein translation and stress granule dynamics in C9orf72-associated frontotemporal dementia and amyotrophic lateral sclerosis. Nature Medicine. PMID 29942091 DOI: 10.1038/S41591-018-0071-1  1
2018 Nicholson AM, Zhou X, Perkerson RB, Parsons TM, Chew J, Brooks M, DeJesus-Hernandez M, Finch NA, Matchett BJ, Kurti A, Jansen-West KR, Perkerson E, Daughrity L, Castanedes-Casey M, Rousseau L, ... ... Petrucelli L, et al. Loss of Tmem106b is unable to ameliorate frontotemporal dementia-like phenotypes in an AAV mouse model of C9ORF72-repeat induced toxicity. Acta Neuropathologica Communications. 6: 42. PMID 29855382 DOI: 10.1186/S40478-018-0545-X  1
2018 Saldi TK, Gonzales P, Garrido-Lecca A, Dostal V, Roberts CM, Petrucelli L, Link CD. The ortholog of TDP-43 regulates the chromatin localization of the heterochromatin protein 1 homolog, HPL-2. Molecular and Cellular Biology. PMID 29760282 DOI: 10.1128/Mcb.00668-17  1
2018 Pottier C, Zhou X, Perkerson RB, Baker M, Jenkins GD, Serie DJ, Ghidoni R, Benussi L, Binetti G, López de Munain A, Zulaica M, Moreno F, Le Ber I, Pasquier F, Hannequin D, ... ... Petrucelli L, et al. Potential genetic modifiers of disease risk and age at onset in patients with frontotemporal lobar degeneration and GRN mutations: a genome-wide association study. The Lancet. Neurology. PMID 29724592 DOI: 10.1016/S1474-4422(18)30126-1  1
2018 Pickles S, Petrucelli L. CRISPR expands insight into the mechanisms of ALS and FTD. Nature Reviews. Neurology. PMID 29695800 DOI: 10.1038/S41582-018-0005-Z  0.01
2018 Tabet R, Schaeffer L, Freyermuth F, Jambeau M, Workman M, Lee CZ, Lin CC, Jiang J, Jansen-West K, Abou-Hamdan H, Désaubry L, Gendron T, Petrucelli L, Martin F, Lagier-Tourenne C. CUG initiation and frameshifting enable production of dipeptide repeat proteins from ALS/FTD C9ORF72 transcripts. Nature Communications. 9: 152. PMID 29323119 DOI: 10.1038/S41467-017-02643-5  1
2018 Chou CC, Zhang Y, Umoh ME, Vaughan SW, Lorenzini I, Liu F, Sayegh M, Donlin-Asp PG, Chen YH, Duong DM, Seyfried NT, Powers MA, Kukar T, Hales CM, Gearing M, ... ... Petrucelli L, et al. TDP-43 pathology disrupts nuclear pore complexes and nucleocytoplasmic transport in ALS/FTD. Nature Neuroscience. PMID 29311743 DOI: 10.1038/S41593-017-0047-3  1
2018 Swinnen B, Bento-Abreu A, Gendron TF, Boeynaems S, Bogaert E, Nuyts R, Timmers M, Scheveneels W, Hersmus N, Wang J, Mizielinska S, Isaacs AM, Petrucelli L, Lemmens R, Van Damme P, et al. A zebrafish model for C9orf72 ALS reveals RNA toxicity as a pathogenic mechanism. Acta Neuropathologica. PMID 29302778 DOI: 10.1007/S00401-017-1796-5  1
2018 Kornak J, Fields JA, Farmer S, Boeve BF, Rosen HJ, Boxer AL, Bove J, Brushaber D, Coppola G, Dheel C, Dickerson BC, Dickinson S, Faber K, Fong J, Foroud TM, ... ... Petrucelli L, et al. P1-281: Nonlinear N-Score Estimation For Establishing Cognitive Norms From The National Alzheimer'S Coordinating Center (Nacc) Dataset Alzheimers & Dementia. 14. DOI: 10.1016/J.Jalz.2018.06.287  1
2017 McGoldrick P, Zhang M, van Blitterswijk M, Sato C, Moreno D, Xiao S, Zhang AB, McKeever PM, Weichert A, Schneider R, Keith J, Petrucelli L, Rademakers R, Zinman L, Robertson J, et al. Unaffected mosaic C9orf72 case: RNA foci, dipeptide proteins, but upregulated C9orf72 expression. Neurology. PMID 29282338 DOI: 10.1212/Wnl.0000000000004865  1
2017 Farhan SMK, Gendron TF, Petrucelli L, Hegele RA, Strong MJ. OPTN p.Met468Arg and ATXN2 intermediate length polyQ extension in families with C9orf72 mediated amyotrophic lateral sclerosis and frontotemporal dementia. American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics. PMID 29080331 DOI: 10.1002/Ajmg.B.32606  1
2017 Lee YB, Baskaran P, Gomez J, Chen HJ, Nishimura A, Smith B, Troakes C, Adachi Y, Stepto A, Petrucelli L, Gallo JM, Hirth F, Rogelj B, Guthrie S, Shaw CE. C9orf72 poly GA RAN-translated protein plays a key role in Amyotrophic Lateral Sclerosis via aggregation and toxicity. Human Molecular Genetics. PMID 28973350 DOI: 10.1093/Hmg/Ddx350  1
2017 Farhan SMK, Gendron TF, Petrucelli L, Hegele RA, Strong MJ. ARHGEF28 p.Lys280Metfs40Ter in an amyotrophic lateral sclerosis family with a C9orf72 expansion. Neurology. Genetics. 3: e190. PMID 28971145 DOI: 10.1212/Nxg.0000000000000190  1
2017 Josephs KA, Dickson DW, Tosakulwong N, Weigand SD, Murray ME, Petrucelli L, Liesinger AM, Senjem ML, Spychalla AJ, Knopman DS, Parisi JE, Petersen RC, Jack CR, Whitwell JL. Rates of hippocampal atrophy and presence of post-mortem TDP-43 in patients with Alzheimer's disease: a longitudinal retrospective study. The Lancet. Neurology. PMID 28919059 DOI: 10.1016/S1474-4422(17)30284-3  1
2017 Mackenzie IR, Nicholson AM, Sarkar M, Messing J, Purice MD, Pottier C, Annu K, Baker M, Perkerson RB, Kurti A, Matchett BJ, Mittag T, Temirov J, Hsiung GR, Krieger C, ... ... Petrucelli L, et al. TIA1 Mutations in Amyotrophic Lateral Sclerosis and Frontotemporal Dementia Promote Phase Separation and Alter Stress Granule Dynamics. Neuron. 95: 808-816.e9. PMID 28817800 DOI: 10.1016/J.Neuron.2017.07.025  1
2017 Carlomagno Y, Chung DC, Yue M, Castanedes-Casey M, Madden BJ, Dunmore J, Tong J, DeTure M, Dickson DW, Petrucelli L, Cook C. An acetylation-phosphorylation switch that regulates tau aggregation propensity and function. The Journal of Biological Chemistry. PMID 28760828 DOI: 10.1074/Jbc.M117.794602  1
2017 Lee CW, Stankowski JN, Chew J, Cook CN, Lam YW, Almeida S, Carlomagno Y, Lau KF, Prudencio M, Gao FB, Bogyo M, Dickson DW, Petrucelli L. The lysosomal protein cathepsin L is a progranulin protease. Molecular Neurodegeneration. 12: 55. PMID 28743268 DOI: 10.1186/S13024-017-0196-6  1
2017 Wojtas AM, Kang SS, Olley BM, Gatherer M, Shinohara M, Lozano PA, Liu CC, Kurti A, Baker KE, Dickson DW, Yue M, Petrucelli L, Bu G, Carare RO, Fryer JD. Loss of clusterin shifts amyloid deposition to the cerebrovasculature via disruption of perivascular drainage pathways. Proceedings of the National Academy of Sciences of the United States of America. PMID 28701379 DOI: 10.1016/J.Jalz.2017.06.250  1
2017 Finch NA, Wang X, Baker MC, Heckman MG, Gendron TF, Bieniek KF, Wuu J, DeJesus-Hernandez M, Brown PH, Chew J, Jansen-West KR, Daughrity LM, Nicholson AM, Murray ME, Josephs KA, ... ... Petrucelli L, et al. Abnormal expression of homeobox genes and transthyretin in C9ORF72 expansion carriers. Neurology. Genetics. 3: e161. PMID 28660252 DOI: 10.1212/Nxg.0000000000000161  1
2017 Prudencio M, Gonzales PK, Cook CN, Gendron TF, Daughrity LM, Song Y, Ebbert MTW, van Blitterswijk M, Zhang YJ, Jansen-West K, Baker MC, DeTure M, Rademakers R, Boylan KB, Dickson DW, ... Petrucelli L, et al. Repetitive element transcripts are elevated in the brain of C9orf72 ALS/FTLD patients. Human Molecular Genetics. PMID 28637276 DOI: 10.1093/Hmg/Ddx233  1
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2017 Petrucelli L, Gitler AD. Unlocking the Mystery of ALS. Scientific American. 316: 46-51. PMID 28510559 DOI: 10.1038/Scientificamerican0617-46  0.04
2017 DeJesus-Hernandez M, Finch NA, Wang X, Gendron TF, Bieniek KF, Heckman MG, Vasilevich A, Murray ME, Rousseau L, Weesner R, Lucido A, Parsons M, Chew J, Josephs KA, Parisi JE, ... ... Petrucelli L, et al. In-depth clinico-pathological examination of RNA foci in a large cohort of C9ORF72 expansion carriers. Acta Neuropathologica. PMID 28508101 DOI: 10.1007/S00401-017-1725-7  1
2017 Kawamata H, Peixoto P, Konrad C, Palomo G, Bredvik K, Gerges M, Valsecchi F, Petrucelli L, Ravits JM, Starkov A, Manfredi G. Mutant TDP-43 does not impair mitochondrial bioenergetics in vitro and in vivo. Molecular Neurodegeneration. 12: 37. PMID 28482850 DOI: 10.1186/S13024-017-0180-1  0.01
2017 Schludi MH, Becker L, Garrett L, Gendron TF, Zhou Q, Schreiber F, Popper B, Dimou L, Strom TM, Winkelmann J, von Thaden A, Rentzsch K, May S, Michaelsen M, Schwenk BM, ... ... Petrucelli L, et al. Spinal poly-GA inclusions in a C9orf72 mouse model trigger motor deficits and inflammation without neuron loss. Acta Neuropathologica. PMID 28409281 DOI: 10.1007/S00401-017-1711-0  1
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2017 Moujalled D, Grubman A, Acevedo K, Yang S, Ke YD, Moujalled DM, Duncan C, Caragounis A, Perera ND, Turner BJ, Prudencio M, Petrucelli L, Blair I, Ittner LM, Crouch PJ, et al. TDP-43 mutations causing amyotrophic lateral sclerosis are associated with altered expression of RNA-binding protein hnRNP K and affect the Nrf2 antioxidant pathway. Human Molecular Genetics. PMID 28334913 DOI: 10.1093/Hmg/Ddx093  1
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2017 Meeter LHH, Gendron TF, Sias AC, Jiskoot LC, Graff C, Boxer AL, Sánchez-Valle R, Pijnenburg YAL, Benussi L, Ghidoni R, Borroni B, Laforce R, Cardoso MJ, Ourselin S, Cash DM, ... ... Petrucelli L, et al. Poly-Gp Dipeptide Repeats And Neurofilament Light Chain As Biomarkers In Presymptomatic And Symptomatic Frontotemporal Dementia Caused By C9Orf72 Repeat Expansions Alzheimers & Dementia. 13. DOI: 10.1016/J.Jalz.2017.07.425  1
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2016 Lopez-Gonzalez R, Lu Y, Gendron TF, Karydas A, Tran H, Yang D, Petrucelli L, Miller BL, Almeida S, Gao FB. Poly(GR) in C9ORF72-Related ALS/FTD Compromises Mitochondrial Function and Increases Oxidative Stress and DNA Damage in iPSC-Derived Motor Neurons. Neuron. PMID 27720481 DOI: 10.1016/J.Neuron.2016.09.015  1
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2016 Vanderweyde T, Apicco DJ, Youmans-Kidder K, Ash PE, Cook C, Lummertz da Rocha E, Jansen-West K, Frame AA, Citro A, Leszyk JD, Ivanov P, Abisambra JF, Steffen M, Li H, Petrucelli L, et al. Interaction of tau with the RNA-binding Protein TIA1 Regulates tau Pathophysiology and Toxicity. Cell Reports. PMID 27160897 DOI: 10.1016/J.Celrep.2016.04.045  1
2016 Jiang J, Zhu Q, Gendron TF, Saberi S, McAlonis-Downes M, Seelman A, Stauffer JE, Jafar-Nejad P, Drenner K, Schulte D, Chun S, Sun S, Ling SC, Myers B, Engelhardt J, ... ... Petrucelli L, et al. Gain of Toxicity from ALS/FTD-Linked Repeat Expansions in C9ORF72 Is Alleviated by Antisense Oligonucleotides Targeting GGGGCC-Containing RNAs. Neuron. PMID 27112497 DOI: 10.1016/J.Neuron.2016.04.006  1
2016 Todd TW, Petrucelli L. Insights into the pathogenic mechanisms of Chromosome 9 open reading frame 72 (C9orf72) repeat expansions. Journal of Neurochemistry. PMID 27016280 DOI: 10.1111/Jnc.13623  1
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2015 O'Rourke JG, Bogdanik L, Muhammad AK, Gendron TF, Kim KJ, Austin A, Cady J, Liu EY, Zarrow J, Grant S, Ho R, Bell S, Carmona S, Simpkinson M, Lall D, ... ... Petrucelli L, et al. C9orf72 BAC Transgenic Mice Display Typical Pathologic Features of ALS/FTD. Neuron. 88: 892-901. PMID 26637796 DOI: 10.1016/J.Neuron.2015.10.027  1
2015 Mohagheghi F, Prudencio M, Stuani C, Cook C, Jansen-West K, Dickson DW, Petrucelli L, Buratti E. TDP-43 functions within a network of hnRNP proteins to inhibit the production of a truncated human SORT1 receptor. Human Molecular Genetics. PMID 26614389 DOI: 10.1093/Hmg/Ddv491  1
2015 van Blitterswijk M, Gendron TF, Baker MC, DeJesus-Hernandez M, Finch NA, Brown PH, Daughrity LM, Murray ME, Heckman MG, Jiang J, Lagier-Tourenne C, Edbauer D, Cleveland DW, Josephs KA, Parisi JE, ... ... Petrucelli L, et al. Novel clinical associations with specific C9ORF72 transcripts in patients with repeat expansions in C9ORF72. Acta Neuropathologica. PMID 26437865 DOI: 10.1007/S00401-015-1480-6  1
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2015 Cook C, Kang SS, Carlomagno Y, Lin WL, Yue M, Kurti A, Shinohara M, Jansen-West K, Perkerson E, Castanedes-Casey M, Rousseau L, Phillips V, Bu G, Dickson DW, Petrucelli L, et al. Tau deposition drives neuropathological, inflammatory, and behavioral abnormalities independently of neuronal loss in a novel mouse model. Human Molecular Genetics. PMID 26276810 DOI: 10.1093/Hmg/Ddv336  1
2015 Josephs KA, Whitwell JL, Tosakulwong N, Weigand SD, Murray ME, Liesinger AM, Petrucelli L, Senjem ML, Ivnik RJ, Parisi JE, Petersen RC, Dickson DW. TAR DNA-binding protein 43 and pathological subtype of Alzheimer's disease impact clinical features. Annals of Neurology. PMID 26224156 DOI: 10.1002/Ana.24493  1
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2015 Ross OA, Cook C, Petrucelli L. Linking the VPS35 and EIF4G1 pathways in Parkinson's disease. Neuron. 85: 1-3. PMID 25569341 DOI: 10.1016/J.Neuron.2014.12.045  1
2015 Chew J, Gendron TF, Prudencio M, Sasaguri H, Zhang YJ, Castanedes-Casey M, Lee CW, Jansen-West K, Kurti A, Murray ME, Bieniek KF, Bauer PO, Whitelaw EC, Rousseau L, Stankowski JN, ... ... Petrucelli L, et al. C9ORF72 repeat expansions in mice cause TDP-43 pathology, neuronal loss, and behavioral deficits Science. 348: 1151-1154. DOI: 10.1126/science.aaa9344  1
2015 Vanderweyde T, Youmans-Kidder K, Apicco DJ, Ash PEA, Cook C, Petrucelli L, Wolozin B. Interaction between microtubule-associated protein tau and RNA binding proteins stimulates tau misfolding and stress granule formation Alzheimers & Dementia. 11. DOI: 10.1016/J.Jalz.2015.07.417  1
2014 Su Z, Zhang Y, Gendron TF, Bauer PO, Chew J, Yang WY, Fostvedt E, Jansen-West K, Belzil VV, Desaro P, Johnston A, Overstreet K, Oh SY, Todd PK, Berry JD, ... ... Petrucelli L, et al. Discovery of a Biomarker and Lead Small Molecules to Target r(GGGGCC)-Associated Defects in c9FTD/ALS. Neuron. 84: 239. PMID 28898625 DOI: 10.1016/J.Neuron.2014.09.019  1
2014 Gascon E, Lynch K, Ruan H, Almeida S, Verheyden JM, Seeley WW, Dickson DW, Petrucelli L, Sun D, Jiao J, Zhou H, Jakovcevski M, Akbarian S, Yao WD, Gao FB. Alterations in microRNA-124 and AMPA receptors contribute to social behavioral deficits in frontotemporal dementia. Nature Medicine. 20: 1444-51. PMID 25401692 DOI: 10.1038/Nm.3717  1
2014 Saldi TK, Ash PE, Wilson G, Gonzales P, Garrido-Lecca A, Roberts CM, Dostal V, Gendron TF, Stein LD, Blumenthal T, Petrucelli L, Link CD. TDP-1, the Caenorhabditis elegans ortholog of TDP-43, limits the accumulation of double-stranded RNA. The Embo Journal. 33: 2947-66. PMID 25391662 DOI: 10.15252/Embj.201488740  1
2014 van Blitterswijk M, Mullen B, Wojtas A, Heckman MG, Diehl NN, Baker MC, DeJesus-Hernandez M, Brown PH, Murray ME, Hsiung GY, Stewart H, Karydas AM, Finger E, Kertesz A, Bigio EH, ... ... Petrucelli L, et al. Genetic modifiers in carriers of repeat expansions in the C9ORF72 gene. Molecular Neurodegeneration. 9: 38. PMID 25239657 DOI: 10.1186/1750-1326-9-38  1
2014 Zhang YJ, Jansen-West K, Xu YF, Gendron TF, Bieniek KF, Lin WL, Sasaguri H, Caulfield T, Hubbard J, Daughrity L, Chew J, Belzil VV, Prudencio M, Stankowski JN, Castanedes-Casey M, ... ... Petrucelli L, et al. Aggregation-prone c9FTD/ALS poly(GA) RAN-translated proteins cause neurotoxicity by inducing ER stress. Acta Neuropathologica. 128: 505-24. PMID 25173361 DOI: 10.1007/S00401-014-1336-5  1
2014 Su Z, Zhang Y, Gendron TF, Bauer PO, Chew J, Yang WY, Fostvedt E, Jansen-West K, Belzil VV, Desaro P, Johnston A, Overstreet K, Oh SY, Todd PK, Berry JD, ... ... Petrucelli L, et al. Discovery of a biomarker and lead small molecules to target r(GGGGCC)-associated defects in c9FTD/ALS. Neuron. 83: 1043-50. PMID 25132468 DOI: 10.1016/J.Neuron.2014.07.041  1
2014 Cook C, Stankowski JN, Carlomagno Y, Stetler C, Petrucelli L. Acetylation: a new key to unlock tau's role in neurodegeneration. Alzheimer's Research & Therapy. 6: 29. PMID 25031639 DOI: 10.1186/Alzrt259  1
2014 Stoica R, De Vos KJ, Paillusson S, Mueller S, Sancho RM, Lau KF, Vizcay-Barrena G, Lin WL, Xu YF, Lewis J, Dickson DW, Petrucelli L, Mitchell JC, Shaw CE, Miller CC. ER-mitochondria associations are regulated by the VAPB-PTPIP51 interaction and are disrupted by ALS/FTD-associated TDP-43. Nature Communications. 5: 3996. PMID 24893131 DOI: 10.1038/Ncomms4996  1
2014 van Blitterswijk M, Mullen B, Heckman MG, Baker MC, DeJesus-Hernandez M, Brown PH, Murray ME, Hsiung GY, Stewart H, Karydas AM, Finger E, Kertesz A, Bigio EH, Weintraub S, Mesulam M, ... ... Petrucelli L, et al. Ataxin-2 as potential disease modifier in C9ORF72 expansion carriers. Neurobiology of Aging. 35: 2421.e13-7. PMID 24866401 DOI: 10.1016/J.Neurobiolaging.2014.04.016  1
2014 Bieniek KF, van Blitterswijk M, Baker MC, Petrucelli L, Rademakers R, Dickson DW. Expanded C9ORF72 hexanucleotide repeat in depressive pseudodementia. Jama Neurology. 71: 775-81. PMID 24756204 DOI: 10.1001/Jamaneurol.2013.6368  1
2014 Josephs KA, Whitwell JL, Weigand SD, Murray ME, Tosakulwong N, Liesinger AM, Petrucelli L, Senjem ML, Knopman DS, Boeve BF, Ivnik RJ, Smith GE, Jack CR, Parisi JE, Petersen RC, et al. TDP-43 is a key player in the clinical features associated with Alzheimer's disease. Acta Neuropathologica. 127: 811-24. PMID 24659241 DOI: 10.1007/S00401-014-1269-Z  1
2014 Liu-Yesucevitz L, Lin AY, Ebata A, Boon JY, Reid W, Xu YF, Kobrin K, Murphy GJ, Petrucelli L, Wolozin B. ALS-linked mutations enlarge TDP-43-enriched neuronal RNA granules in the dendritic arbor. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 34: 4167-74. PMID 24647938 DOI: 10.1523/Jneurosci.2350-13.2014  1
2014 Carlomagno Y, Zhang Y, Davis M, Lin WL, Cook C, Dunmore J, Tay W, Menkosky K, Cao X, Petrucelli L, Deture M. Casein kinase II induced polymerization of soluble TDP-43 into filaments is inhibited by heat shock proteins. Plos One. 9: e90452. PMID 24595055 DOI: 10.1371/Journal.Pone.0090452  1
2014 Belzil VV, Bauer PO, Gendron TF, Murray ME, Dickson D, Petrucelli L. Characterization of DNA hypermethylation in the cerebellum of c9FTD/ALS patients. Brain Research. 1584: 15-21. PMID 24530272 DOI: 10.1016/J.Brainres.2014.02.015  1
2014 Cook C, Dunmore JH, Murray ME, Scheffel K, Shukoor N, Tong J, Castanedes-Casey M, Phillips V, Rousseau L, Penuliar MS, Kurti A, Dickson DW, Petrucelli L, Fryer JD. Severe amygdala dysfunction in a MAPT transgenic mouse model of frontotemporal dementia. Neurobiology of Aging. 35: 1769-77. PMID 24503275 DOI: 10.1016/J.Neurobiolaging.2013.12.023  1
2014 D'Alton S, Altshuler M, Cannon A, Dickson DW, Petrucelli L, Lewis J. Divergent phenotypes in mutant TDP-43 transgenic mice highlight potential confounds in TDP-43 transgenic modeling. Plos One. 9: e86513. PMID 24466128 DOI: 10.1371/Journal.Pone.0086513  1
2014 Gendron TF, Belzil VV, Zhang YJ, Petrucelli L. Mechanisms of toxicity in C9FTLD/ALS. Acta Neuropathologica. 127: 359-76. PMID 24394885 DOI: 10.1007/S00401-013-1237-Z  1
2014 van Blitterswijk M, Mullen B, Nicholson AM, Bieniek KF, Heckman MG, Baker MC, DeJesus-Hernandez M, Finch NA, Brown PH, Murray ME, Hsiung GY, Stewart H, Karydas AM, Finger E, Kertesz A, ... ... Petrucelli L, et al. TMEM106B protects C9ORF72 expansion carriers against frontotemporal dementia. Acta Neuropathologica. 127: 397-406. PMID 24385136 DOI: 10.1007/S00401-013-1240-4  1
2014 Josephs KA, Murray ME, Whitwell JL, Parisi JE, Petrucelli L, Jack CR, Petersen RC, Dickson DW. Staging TDP-43 pathology in Alzheimer's disease. Acta Neuropathologica. 127: 441-50. PMID 24240737 DOI: 10.1007/S00401-013-1211-9  1
2014 Lee WC, Almeida S, Prudencio M, Caulfield TR, Zhang YJ, Tay WM, Bauer PO, Chew J, Sasaguri H, Jansen-West KR, Gendron TF, Stetler CT, Finch N, Mackenzie IR, Rademakers R, ... ... Petrucelli L, et al. Targeted manipulation of the sortilin-progranulin axis rescues progranulin haploinsufficiency. Human Molecular Genetics. 23: 1467-78. PMID 24163244 DOI: 10.1093/Hmg/Ddt534  1
2014 Kouri N, Carlomagno Y, Baker M, Liesinger AM, Caselli RJ, Wszolek ZK, Petrucelli L, Boeve BF, Parisi JE, Josephs KA, Uitti RJ, Ross OA, Graff-Radford NR, DeTure MA, Dickson DW, et al. Novel mutation in MAPT exon 13 (p.N410H) causes corticobasal degeneration. Acta Neuropathologica. 127: 271-82. PMID 24121548 DOI: 10.1007/S00401-013-1193-7  1
2014 Cook C, Carlomagno Y, Gendron TF, Dunmore J, Scheffel K, Stetler C, Davis M, Dickson D, Jarpe M, DeTure M, Petrucelli L. Acetylation of the KXGS motifs in tau is a critical determinant in modulation of tau aggregation and clearance. Human Molecular Genetics. 23: 104-16. PMID 23962722 DOI: 10.1093/Hmg/Ddt402  1
2014 Belzil VV, Petrucelli L. Epigenetic modifications of the C9ORF72 gene: A potential biomarker of disease? Future Neurology. 9: 123-126. DOI: 10.2217/Fnl.14.5  1
2014 Su Z, Zhang Y, Gendron TF, Bauer PO, Chew J, Yang WY, Fostvedt E, Jansen-West K, Belzil VV, Desaro P, Johnston A, Overstreet K, Oh SY, Todd PK, Berry JD, ... ... Petrucelli L, et al. Errata to Discovery of a biomarker and lead small molecules to target r(GGGGCC)-Associated Defects in c9FTD/ALS [Neuron, 83, (2014) 1043-1050] Neuron. 84: 239. DOI: 10.1016/j.neuron.2014.09.019  1
2013 Dayton RD, Gitcho MA, Orchard EA, Wilson JD, Wang DB, Cain CD, Johnson JA, Zhang YJ, Petrucelli L, Mathis JM, Klein RL. Selective Forelimb Impairment in Rats Expressing a Pathological TDP-43 25 kDa C-terminal Fragment to Mimic Amyotrophic Lateral Sclerosis. Molecular Therapy : the Journal of the American Society of Gene Therapy. 21: 1324-1334. PMID 28160795 DOI: 10.1038/mt.2013.88  1
2013 Mann DM, Rollinson S, Robinson A, Bennion Callister J, Thompson JC, Snowden JS, Gendron T, Petrucelli L, Masuda-Suzukake M, Hasegawa M, Davidson Y, Pickering-Brown S. Dipeptide repeat proteins are present in the p62 positive inclusions in patients with frontotemporal lobar degeneration and motor neurone disease associated with expansions in C9ORF72. Acta Neuropathologica Communications. 1: 68. PMID 24252525 DOI: 10.1186/2051-5960-1-68  1
2013 Belzil VV, Bauer PO, Prudencio M, Gendron TF, Stetler CT, Yan IK, Pregent L, Daughrity L, Baker MC, Rademakers R, Boylan K, Patel TC, Dickson DW, Petrucelli L. Reduced C9orf72 gene expression in c9FTD/ALS is caused by histone trimethylation, an epigenetic event detectable in blood. Acta Neuropathologica. 126: 895-905. PMID 24166615 DOI: 10.1007/S00401-013-1199-1  1
2013 Sareen D, O'Rourke JG, Meera P, Muhammad AK, Grant S, Simpkinson M, Bell S, Carmona S, Ornelas L, Sahabian A, Gendron T, Petrucelli L, Baughn M, Ravits J, Harms MB, et al. Targeting RNA foci in iPSC-derived motor neurons from ALS patients with a C9ORF72 repeat expansion. Science Translational Medicine. 5: 208ra149. PMID 24154603 DOI: 10.1126/Scitranslmed.3007529  1
2013 Donnelly CJ, Zhang PW, Pham JT, Haeusler AR, Heusler AR, Mistry NA, Vidensky S, Daley EL, Poth EM, Hoover B, Fines DM, Maragakis N, Tienari PJ, Petrucelli L, Traynor BJ, et al. RNA toxicity from the ALS/FTD C9ORF72 expansion is mitigated by antisense intervention. Neuron. 80: 415-28. PMID 24139042 DOI: 10.1016/J.Neuron.2013.10.015  1
2013 Gendron TF, Bieniek KF, Zhang YJ, Jansen-West K, Ash PE, Caulfield T, Daughrity L, Dunmore JH, Castanedes-Casey M, Chew J, Cosio DM, van Blitterswijk M, Lee WC, Rademakers R, Boylan KB, ... ... Petrucelli L, et al. Antisense transcripts of the expanded C9ORF72 hexanucleotide repeat form nuclear RNA foci and undergo repeat-associated non-ATG translation in c9FTD/ALS. Acta Neuropathologica. 126: 829-44. PMID 24129584 DOI: 10.1007/S00401-013-1192-8  1
2013 van Blitterswijk M, Baker MC, DeJesus-Hernandez M, Ghidoni R, Benussi L, Finger E, Hsiung GY, Kelley BJ, Murray ME, Rutherford NJ, Brown PE, Ravenscroft T, Mullen B, Ash PE, Bieniek KF, ... ... Petrucelli L, et al. C9ORF72 repeat expansions in cases with previously identified pathogenic mutations. Neurology. 81: 1332-41. PMID 24027057 DOI: 10.1212/Wnl.0B013E3182A8250C  1
2013 van Blitterswijk M, DeJesus-Hernandez M, Niemantsverdriet E, Murray ME, Heckman MG, Diehl NN, Brown PH, Baker MC, Finch NA, Bauer PO, Serrano G, Beach TG, Josephs KA, Knopman DS, Petersen RC, ... ... Petrucelli L, et al. Association between repeat sizes and clinical and pathological characteristics in carriers of C9ORF72 repeat expansions (Xpansize-72): a cross-sectional cohort study. The Lancet. Neurology. 12: 978-88. PMID 24011653 DOI: 10.1016/S1474-4422(13)70210-2  1
2013 Murray ME, Bieniek KF, Banks Greenberg M, DeJesus-Hernandez M, Rutherford NJ, van Blitterswijk M, Niemantsverdriet E, Ash PE, Gendron TF, Kouri N, Baker M, Goodman IJ, Petrucelli L, Rademakers R, Dickson DW. Progressive amnestic dementia, hippocampal sclerosis, and mutation in C9ORF72. Acta Neuropathologica. 126: 545-54. PMID 23922030 DOI: 10.1007/S00401-013-1161-2  1
2013 Gendron TF, Cosio DM, Petrucelli L. c9RAN translation: a potential therapeutic target for the treatment of amyotrophic lateral sclerosis and frontotemporal dementia. Expert Opinion On Therapeutic Targets. 17: 991-5. PMID 23844663 DOI: 10.1517/14728222.2013.818659  1
2013 Almeida S, Gascon E, Tran H, Chou HJ, Gendron TF, Degroot S, Tapper AR, Sellier C, Charlet-Berguerand N, Karydas A, Seeley WW, Boxer AL, Petrucelli L, Miller BL, Gao FB. Modeling key pathological features of frontotemporal dementia with C9ORF72 repeat expansion in iPSC-derived human neurons. Acta Neuropathologica. 126: 385-99. PMID 23836290 DOI: 10.1007/S00401-013-1149-Y  1
2013 Wang W, Li L, Lin WL, Dickson DW, Petrucelli L, Zhang T, Wang X. The ALS disease-associated mutant TDP-43 impairs mitochondrial dynamics and function in motor neurons. Human Molecular Genetics. 22: 4706-19. PMID 23827948 DOI: 10.1093/Hmg/Ddt319  1
2013 Fratta P, Poulter M, Lashley T, Rohrer JD, Polke JM, Beck J, Ryan N, Hensman D, Mizielinska S, Waite AJ, Lai MC, Gendron TF, Petrucelli L, Fisher EM, Revesz T, et al. Homozygosity for the C9orf72 GGGGCC repeat expansion in frontotemporal dementia. Acta Neuropathologica. 126: 401-9. PMID 23818065 DOI: 10.1007/S00401-013-1147-0  1
2013 Dayton RD, Gitcho MA, Orchard EA, Wilson JD, Wang DB, Cain CD, Johnson JA, Zhang YJ, Petrucelli L, Mathis JM, Klein RL. Selective forelimb impairment in rats expressing a pathological TDP-43 25 kDa C-terminal fragment to mimic amyotrophic lateral sclerosis. Molecular Therapy : the Journal of the American Society of Gene Therapy. 21: 1324-34. PMID 23689600 DOI: 10.1038/Mt.2013.88  1
2013 Clippinger AK, D'Alton S, Lin WL, Gendron TF, Howard J, Borchelt DR, Cannon A, Carlomagno Y, Chakrabarty P, Cook C, Golde TE, Levites Y, Ranum L, Schultheis PJ, Xu G, ... Petrucelli L, et al. Robust cytoplasmic accumulation of phosphorylated TDP-43 in transgenic models of tauopathy. Acta Neuropathologica. 126: 39-50. PMID 23666556 DOI: 10.1007/S00401-013-1123-8  1
2013 Gendron TF, Zhang YJ, Petrucelli L. Does obesity-induced Ï„ phosphorylation tip the scale toward dementia? Diabetes. 62: 1365-6. PMID 23613550 DOI: 10.2337/Db12-1784  1
2013 Zhang YJ, Caulfield T, Xu YF, Gendron TF, Hubbard J, Stetler C, Sasaguri H, Whitelaw EC, Cai S, Lee WC, Petrucelli L. The dual functions of the extreme N-terminus of TDP-43 in regulating its biological activity and inclusion formation. Human Molecular Genetics. 22: 3112-22. PMID 23575225 DOI: 10.1093/Hmg/Ddt166  1
2013 Ash PE, Bieniek KF, Gendron TF, Caulfield T, Lin WL, Dejesus-Hernandez M, van Blitterswijk MM, Jansen-West K, Paul JW, Rademakers R, Boylan KB, Dickson DW, Petrucelli L. Unconventional translation of C9ORF72 GGGGCC expansion generates insoluble polypeptides specific to c9FTD/ALS. Neuron. 77: 639-46. PMID 23415312 DOI: 10.1016/J.Neuron.2013.02.004  1
2013 Belzil VV, Gendron TF, Petrucelli L. RNA-mediated toxicity in neurodegenerative disease. Molecular and Cellular Neurosciences. 56: 406-19. PMID 23280309 DOI: 10.1016/J.Mcn.2012.12.006  1
2013 Rayaprolu S, Fujioka S, Traynor S, Soto-Ortolaza AI, Petrucelli L, Dickson DW, Rademakers R, Boylan KB, Graff-Radford NR, Uitti RJ, Wszolek ZK, Ross OA. TARDBP mutations in Parkinson's disease. Parkinsonism & Related Disorders. 19: 312-5. PMID 23231971 DOI: 10.1016/J.Parkreldis.2012.11.003  1
2013 Gendron TF, Rademakers R, Petrucelli L. TARDBP mutation analysis in TDP-43 proteinopathies and deciphering the toxicity of mutant TDP-43. Journal of Alzheimer's Disease : Jad. 33: S35-45. PMID 22751173 DOI: 10.3233/Jad-2012-129036  1
2013 Cook C, Petrucelli L. Tau triage decisions mediated by the chaperone network. Journal of Alzheimer's Disease : Jad. 33: S145-51. PMID 22596270 DOI: 10.3233/Jad-2012-129008  1
2013 Donnelly CJ, Zhang PW, Pham JT, Haeusler AR, Mistry NA, Vidensky S, Daley EL, Poth EM, Hoover B, Fines DM, Maragakis N, Tienari PJ, Petrucelli L, Traynor BJ, Wang J, et al. RNA Toxicity from the ALS/FTD C9ORF72 expansion is mitigated by antisense intervention [Neuron, 79, (September 18, 2013), 1222-1231] Neuron. 80: 1102. DOI: 10.1016/J.Neuron.2013.10.055  1
2012 Prudencio M, Jansen-West KR, Lee WC, Gendron TF, Zhang YJ, Xu YF, Gass J, Stuani C, Stetler C, Rademakers R, Dickson DW, Buratti E, Petrucelli L. Misregulation of human sortilin splicing leads to the generation of a nonfunctional progranulin receptor. Proceedings of the National Academy of Sciences of the United States of America. 109: 21510-5. PMID 23236149 DOI: 10.1073/Pnas.1211577110  1
2012 Vaccaro A, Tauffenberger A, Ash PE, Carlomagno Y, Petrucelli L, Parker JA. TDP-1/TDP-43 regulates stress signaling and age-dependent proteotoxicity in Caenorhabditis elegans. Plos Genetics. 8: e1002806. PMID 22792076 DOI: 10.1371/Journal.Pgen.1002806  1
2012 Gass J, Lee WC, Cook C, Finch N, Stetler C, Jansen-West K, Lewis J, Link CD, Rademakers R, Nykjær A, Petrucelli L. Progranulin regulates neuronal outgrowth independent of sortilin. Molecular Neurodegeneration. 7: 33. PMID 22781549 DOI: 10.1186/1750-1326-7-33  1
2012 Cook C, Stetler C, Petrucelli L. Disruption of protein quality control in Parkinson's disease. Cold Spring Harbor Perspectives in Medicine. 2: a009423. PMID 22553500 DOI: 10.1101/Cshperspect.A009423  1
2012 Cannon A, Yang B, Knight J, Farnham IM, Zhang Y, Wuertzer CA, D'Alton S, Lin WL, Castanedes-Casey M, Rousseau L, Scott B, Jurasic M, Howard J, Yu X, Bailey R, ... ... Petrucelli L, et al. Neuronal sensitivity to TDP-43 overexpression is dependent on timing of induction. Acta Neuropathologica. 123: 807-23. PMID 22539017 DOI: 10.1007/S00401-012-0979-3  1
2012 Lorusso V, Giampaglia M, Petrucelli L, Saracino V, Perrone T, Gnoni A. Antiemetic efficacy of single-dose palonosetron and dexamethasone in patients receiving multiple cycles of multiple day-based chemotherapy. Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer. 20: 3241-6. PMID 22534864 DOI: 10.1007/s00520-012-1469-9  1
2012 Cook C, Gendron TF, Scheffel K, Carlomagno Y, Dunmore J, DeTure M, Petrucelli L. Loss of HDAC6, a novel CHIP substrate, alleviates abnormal tau accumulation. Human Molecular Genetics. 21: 2936-45. PMID 22492994 DOI: 10.1093/Hmg/Dds125  1
2012 Gass J, Prudencio M, Stetler C, Petrucelli L. Progranulin: an emerging target for FTLD therapies. Brain Research. 1462: 118-28. PMID 22338605 DOI: 10.1016/J.Brainres.2012.01.047  1
2012 Nicholson AM, Gass J, Petrucelli L, Rademakers R. Progranulin axis and recent developments in frontotemporal lobar degeneration. Alzheimer's Research & Therapy. 4: 4. PMID 22277331 DOI: 10.1186/Alzrt102  1
2011 Xu YF, Zhang YJ, Lin WL, Cao X, Stetler C, Dickson DW, Lewis J, Petrucelli L. Expression of mutant TDP-43 induces neuronal dysfunction in transgenic mice. Molecular Neurodegeneration. 6: 73. PMID 22029574 DOI: 10.1186/1750-1326-6-73  1
2011 Gendron TF, Petrucelli L. Rodent models of TDP-43 proteinopathy: investigating the mechanisms of TDP-43-mediated neurodegeneration. Journal of Molecular Neuroscience : Mn. 45: 486-99. PMID 21811811 DOI: 10.1007/S12031-011-9610-7  1
2010 Liu-Yesucevitz L, Bilgutay A, Zhang YJ, Vanderweyde T, Vanderwyde T, Citro A, Mehta T, Zaarur N, McKee A, Bowser R, Sherman M, Petrucelli L, Wolozin B. Tar DNA binding protein-43 (TDP-43) associates with stress granules: analysis of cultured cells and pathological brain tissue. Plos One. 5: e13250. PMID 20948999 DOI: 10.1371/Journal.Pone.0013250  1
2010 Zhang YJ, Gendron TF, Xu YF, Ko LW, Yen SH, Petrucelli L. Phosphorylation regulates proteasomal-mediated degradation and solubility of TAR DNA binding protein-43 C-terminal fragments. Molecular Neurodegeneration. 5: 33. PMID 20804554 DOI: 10.1186/1750-1326-5-33  1
2010 Lee BD, Shin JH, VanKampen J, Petrucelli L, West AB, Ko HS, Lee YI, Maguire-Zeiss KA, Bowers WJ, Federoff HJ, Dawson VL, Dawson TM. Inhibitors of leucine-rich repeat kinase-2 protect against models of Parkinson's disease. Nature Medicine. 16: 998-1000. PMID 20729864 DOI: 10.1038/Nm.2199  1
2010 Xu YF, Gendron TF, Zhang YJ, Lin WL, D'Alton S, Sheng H, Casey MC, Tong J, Knight J, Yu X, Rademakers R, Boylan K, Hutton M, McGowan E, Dickson DW, ... ... Petrucelli L, et al. Wild-type human TDP-43 expression causes TDP-43 phosphorylation, mitochondrial aggregation, motor deficits, and early mortality in transgenic mice. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 30: 10851-9. PMID 20702714 DOI: 10.1523/Jneurosci.1630-10.2010  1
2010 Deture M, Hicks C, Petrucelli L. Targeting heat shock proteins in tauopathies. Current Alzheimer Research. 7: 677-84. PMID 20678072  1
2010 Ash PE, Zhang YJ, Roberts CM, Saldi T, Hutter H, Buratti E, Petrucelli L, Link CD. Neurotoxic effects of TDP-43 overexpression in C. elegans. Human Molecular Genetics. 19: 3206-18. PMID 20530643 DOI: 10.1093/Hmg/Ddq230  1
2010 Ahmed Z, Sheng H, Xu YF, Lin WL, Innes AE, Gass J, Yu X, Wuertzer CA, Hou H, Chiba S, Yamanouchi K, Leissring M, Petrucelli L, Nishihara M, Hutton ML, et al. Accelerated lipofuscinosis and ubiquitination in granulin knockout mice suggest a role for progranulin in successful aging. The American Journal of Pathology. 177: 311-24. PMID 20522652 DOI: 10.2353/Ajpath.2010.090915  1
2010 Adams SJ, DeTure MA, McBride M, Dickson DW, Petrucelli L. Three repeat isoforms of tau inhibit assembly of four repeat tau filaments. Plos One. 5: e10810. PMID 20520830 DOI: 10.1371/Journal.Pone.0010810  1
2010 Gendron TF, Josephs KA, Petrucelli L. Review: transactive response DNA-binding protein 43 (TDP-43): mechanisms of neurodegeneration. Neuropathology and Applied Neurobiology. 36: 97-112. PMID 20202122 DOI: 10.1111/J.1365-2990.2010.01060.X  1
2010 Golde TE, Petrucelli L, Lewis J. Targeting Abeta and tau in Alzheimer's disease, an early interim report. Experimental Neurology. 223: 252-66. PMID 19716367 DOI: 10.1016/J.Expneurol.2009.07.035  1
2010 Ahmed Z, Sheng H, Xu YF, Lin WL, Innes AE, Gass J, Yu X, Wuertzer CA, Hou H, Chiba S, Yamanouchi K, Leissring M, Petrucelli L, Nishihara M, Hutton ML, et al. Accelerated lipofuscinosis and ubiquitination in granulin knockout mice suggest a role for progranulin in successful aging (American Journal of Pathology (2010), 177, (311-324)) American Journal of Pathology. 177: 2146. DOI: 10.2353/Ajpath.2010.100772  1
2010 Ahmed Z, Sheng H, Xu Y, Lin W, Innes AE, Yu X, Hou H, Chiba S, Yamanouchi K, Petrucelli L, Nishihara M, Hutton ML, McGowan E, Dickson DW, Lewis J. Accelerated lipofuscinosis and ubiquitination in granulin knockout mice suggests a role for progranulin in successful aging Alzheimers & Dementia. 6. DOI: 10.1016/J.Jalz.2010.05.249  1
2009 Cook C, Gass J, Dunmore J, Tong J, Taylor J, Eriksen J, McGowan E, Lewis J, Johnston J, Petrucelli L. Aging is not associated with proteasome impairment in UPS reporter mice. Plos One. 4: e5888. PMID 19517018 DOI: 10.1371/Journal.Pone.0005888  1
2009 Cook C, Petrucelli L. A critical evaluation of the ubiquitin-proteasome system in Parkinson's disease. Biochimica Et Biophysica Acta. 1792: 664-75. PMID 19419700 DOI: 10.1016/J.Bbadis.2009.01.012  1
2009 Zhang YJ, Xu YF, Cook C, Gendron TF, Roettges P, Link CD, Lin WL, Tong J, Castanedes-Casey M, Ash P, Gass J, Rangachari V, Buratti E, Baralle F, Golde TE, ... ... Petrucelli L, et al. Aberrant cleavage of TDP-43 enhances aggregation and cellular toxicity. Proceedings of the National Academy of Sciences of the United States of America. 106: 7607-12. PMID 19383787 DOI: 10.1073/Pnas.0900688106  1
2009 Bett JS, Cook C, Petrucelli L, Bates GP. The ubiquitin-proteasome reporter GFPu does not accumulate in neurons of the R6/2 transgenic mouse model of Huntington's disease. Plos One. 4: e5128. PMID 19352500 DOI: 10.1371/Journal.Pone.0005128  1
2009 Lorusso V, Spedicato A, Petrucelli L, Saracino V, Giampaglia M, Perrone T. Single dose of palonosetron plus dexamethasone to control nausea, vomiting and to warrant an adequate food intake in patients treated with highly emetogenic chemotherapy (HEC). Preliminary results. Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer. 17: 1469-73. PMID 19294429 DOI: 10.1007/s00520-009-0611-9  1
2009 Gendron TF, Petrucelli L. The role of tau in neurodegeneration. Molecular Neurodegeneration. 4: 13. PMID 19284597 DOI: 10.1186/1750-1326-4-13  0.4
2009 Ko HS, Bailey R, Smith WW, Liu Z, Shin JH, Lee YI, Zhang YJ, Jiang H, Ross CA, Moore DJ, Patterson C, Petrucelli L, Dawson TM, Dawson VL. CHIP regulates leucine-rich repeat kinase-2 ubiquitination, degradation, and toxicity. Proceedings of the National Academy of Sciences of the United States of America. 106: 2897-902. PMID 19196961 DOI: 10.1073/Pnas.0810123106  1
2009 Golde TE, Petrucelli L. "What kills neurons in neurodegenerative diseases?", a review series in an open access journal. Molecular Neurodegeneration. 4: 7. PMID 19193221 DOI: 10.1186/1750-1326-4-7  1
2008 Ayala YM, Zago P, D'Ambrogio A, Xu YF, Petrucelli L, Buratti E, Baralle FE. Structural determinants of the cellular localization and shuttling of TDP-43. Journal of Cell Science. 121: 3778-85. PMID 18957508 DOI: 10.1242/Jcs.038950  1
2008 Rutherford NJ, Zhang YJ, Baker M, Gass JM, Finch NA, Xu YF, Stewart H, Kelley BJ, Kuntz K, Crook RJ, Sreedharan J, Vance C, Sorenson E, Lippa C, Bigio EH, ... ... Petrucelli L, et al. Novel mutations in TARDBP (TDP-43) in patients with familial amyotrophic lateral sclerosis. Plos Genetics. 4: e1000193. PMID 18802454 DOI: 10.1371/Journal.Pgen.1000193  1
2008 Cook C, Zhang YJ, Xu YF, Dickson DW, Petrucelli L. TDP-43 in neurodegenerative disorders. Expert Opinion On Biological Therapy. 8: 969-78. PMID 18549326 DOI: 10.1517/14712598.8.7.969  1
2008 Dickey CA, Koren J, Zhang YJ, Xu YF, Jinwal UK, Birnbaum MJ, Monks B, Sun M, Cheng JQ, Patterson C, Bailey RM, Dunmore J, Soresh S, Leon C, Morgan D, ... Petrucelli L, et al. Akt and CHIP coregulate tau degradation through coordinated interactions. Proceedings of the National Academy of Sciences of the United States of America. 105: 3622-7. PMID 18292230 DOI: 10.1073/Pnas.0709180105  1
2008 Petrucelli L, Dickson DW. Neuropathology of Parkinson's Disease Parkinson's Disease. 35-48. DOI: 10.1016/B978-0-12-374028-1.00003-8  1
2007 Dickey CA, Petrucelli L. Commentary on "Cytoskeletal modulators and pleiotropic strategies for Alzheimer drug discovery." The last stand: the dichotomy of chaperone function in Alzheimer's disease. Alzheimer's & Dementia : the Journal of the Alzheimer's Association. 3: 3-6. PMID 19595909 DOI: 10.1016/J.Jalz.2006.09.001  1
2007 Zhang YJ, Xu YF, Dickey CA, Buratti E, Baralle F, Bailey R, Pickering-Brown S, Dickson D, Petrucelli L. Progranulin mediates caspase-dependent cleavage of TAR DNA binding protein-43. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 27: 10530-4. PMID 17898224 DOI: 10.1523/Jneurosci.3421-07.2007  1
2007 Dächsel JC, Taylor JP, Mok SS, Ross OA, Hinkle KM, Bailey RM, Hines JH, Szutu J, Madden B, Petrucelli L, Farrer MJ. Identification of potential protein interactors of Lrrk2. Parkinsonism & Related Disorders. 13: 382-5. PMID 17400507 DOI: 10.1016/J.Parkreldis.2007.01.008  1
2007 Dickey CA, Kamal A, Lundgren K, Klosak N, Bailey RM, Dunmore J, Ash P, Shoraka S, Zlatkovic J, Eckman CB, Patterson C, Dickson DW, Nahman NS, Hutton M, Burrows F, ... Petrucelli L, et al. The high-affinity HSP90-CHIP complex recognizes and selectively degrades phosphorylated tau client proteins. The Journal of Clinical Investigation. 117: 648-58. PMID 17304350 DOI: 10.1172/Jci29715  1
2007 Dickey CA, Patterson C, Dickson D, Petrucelli L. Brain CHIP: removing the culprits in neurodegenerative disease. Trends in Molecular Medicine. 13: 32-8. PMID 17127096 DOI: 10.1016/J.Molmed.2006.11.003  1
2006 Dickey CA, Petrucelli L. Current strategies for the treatment of Alzheimer's disease and other tauopathies. Expert Opinion On Therapeutic Targets. 10: 665-76. PMID 16981824 DOI: 10.1517/14728222.10.5.665  1
2006 Dickey CA, Ash P, Klosak N, Lee WC, Petrucelli L, Hutton M, Eckman CB. Pharmacologic reductions of total tau levels; implications for the role of microtubule dynamics in regulating tau expression. Molecular Neurodegeneration. 1: 6. PMID 16930453 DOI: 10.1186/1750-1326-1-6  1
2006 Bové J, Zhou C, Jackson-Lewis V, Taylor J, Chu Y, Rideout HJ, Wu DC, Kordower JH, Petrucelli L, Przedborski S. Proteasome inhibition and Parkinson's disease modeling. Annals of Neurology. 60: 260-4. PMID 16862585 DOI: 10.1002/Ana.20937  1
2006 Dickey CA, Yue M, Lin WL, Dickson DW, Dunmore JH, Lee WC, Zehr C, West G, Cao S, Clark AM, Caldwell GA, Caldwell KA, Eckman C, Patterson C, Hutton M, ... Petrucelli L, et al. Deletion of the ubiquitin ligase CHIP leads to the accumulation, but not the aggregation, of both endogenous phospho- and caspase-3-cleaved tau species. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 26: 6985-96. PMID 16807328 DOI: 10.1523/Jneurosci.0746-06.2006  1
2006 Klein RL, Dayton RD, Henderson KM, Petrucelli L. Parkin is protective for substantia nigra dopamine neurons in a tau gene transfer neurodegeneration model. Neuroscience Letters. 401: 130-5. PMID 16554120 DOI: 10.1016/J.Neulet.2006.03.001  1
2006 Dickey CA, Dunmore J, Lu B, Wang JW, Lee WC, Kamal A, Burrows F, Eckman C, Hutton M, Petrucelli L. HSP induction mediates selective clearance of tau phosphorylated at proline-directed Ser/Thr sites but not KXGS (MARK) sites. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 20: 753-5. PMID 16464956 DOI: 10.1096/Fj.05-5343Fje  1
2005 Dickey CA, Eriksen J, Kamal A, Burrows F, Kasibhatla S, Eckman CB, Hutton M, Petrucelli L. Development of a high throughput drug screening assay for the detection of changes in tau levels -- proof of concept with HSP90 inhibitors. Current Alzheimer Research. 2: 231-8. PMID 15974923 DOI: 10.2174/1567205053585927  1
2005 Eriksen JL, Wszolek Z, Petrucelli L. Molecular pathogenesis of Parkinson disease. Archives of Neurology. 62: 353-7. PMID 15767499 DOI: 10.1001/Archneur.62.3.353  1
2005 Eriksen JL, Przedborski S, Petrucelli L. Gene dosage and pathogenesis of Parkinson's disease. Trends in Molecular Medicine. 11: 91-6. PMID 15760766 DOI: 10.1016/J.Molmed.2005.01.001  1
2004 Petrucelli L, Dawson TM. Mechanism of neurodegenerative disease: role of the ubiquitin proteasome system. Annals of Medicine. 36: 315-20. PMID 15224658 DOI: 10.1080/07853890410031948  1
2004 Petrucelli L, Dickson D, Kehoe K, Taylor J, Snyder H, Grover A, De Lucia M, McGowan E, Lewis J, Prihar G, Kim J, Dillmann WH, Browne SE, Hall A, Voellmy R, et al. CHIP and Hsp70 regulate tau ubiquitination, degradation and aggregation. Human Molecular Genetics. 13: 703-14. PMID 14962978 DOI: 10.1093/Hmg/Ddh083  1
2004 Eriksen JL, Petrucelli L. Parkinson's disease - Molecular mechanisms of disease Drug Discovery Today: Disease Mechanisms. 1: 399-405. DOI: 10.1016/J.Ddmec.2004.11.016  1
2003 Eriksen JL, Dawson TM, Dickson DW, Petrucelli L. Caught in the act: alpha-synuclein is the culprit in Parkinson's disease. Neuron. 40: 453-6. PMID 14642269 DOI: 10.1016/S0896-6273(03)00684-6  1
2003 Choi P, Snyder H, Petrucelli L, Theisler C, Chong M, Zhang Y, Lim K, Chung KK, Kehoe K, D'Adamio L, Lee JM, Cochran E, Bowser R, Dawson TM, Wolozin B. SEPT5_v2 is a parkin-binding protein. Brain Research. Molecular Brain Research. 117: 179-89. PMID 14559152 DOI: 10.1016/S0169-328X(03)00318-8  1
2002 Petrucelli L, O'Farrell C, Lockhart PJ, Baptista M, Kehoe K, Vink L, Choi P, Wolozin B, Farrer M, Hardy J, Cookson MR. Parkin protects against the toxicity associated with mutant alpha-synuclein: proteasome dysfunction selectively affects catecholaminergic neurons. Neuron. 36: 1007-19. PMID 12495618 DOI: 10.1016/S0896-6273(02)01125-X  1
2002 Lee JM, Petrucelli L, Fisher G, Ramdath S, Castillo J, Di Fiore MM, D'Aniello A. Evidence for D-aspartyl-beta-amyloid secretase activity in human brain. Journal of Neuropathology and Experimental Neurology. 61: 125-31. PMID 11855381  1
2001 O'Farrell C, Murphy DD, Petrucelli L, Singleton AB, Hussey J, Farrer M, Hardy J, Dickson DW, Cookson MR. Transfected synphilin-1 forms cytoplasmic inclusions in HEK293 cells. Brain Research. Molecular Brain Research. 97: 94-102. PMID 11744167 DOI: 10.1016/S0169-328X(01)00292-3  1
2001 Choi P, Golts N, Snyder H, Chong M, Petrucelli L, Hardy J, Sparkman D, Cochran E, Lee JM, Wolozin B. Co-association of parkin and alpha-synuclein. Neuroreport. 12: 2839-43. PMID 11588587 DOI: 10.1097/00001756-200109170-00017  1
2001 Farrer M, Chan P, Chen R, Tan L, Lincoln S, Hernandez D, Forno L, Gwinn-Hardy K, Petrucelli L, Hussey J, Singleton A, Tanner C, Hardy J, Langston JW. Lewy bodies and parkinsonism in families with parkin mutations. Annals of Neurology. 50: 293-300. PMID 11558785 DOI: 10.1002/Ana.1132  1
2001 West A, Farrer M, Petrucelli L, Cookson M, Lockhart P, Hardy J. Identification and characterization of the human parkin gene promoter. Journal of Neurochemistry. 78: 1146-52. PMID 11553688 DOI: 10.1046/J.1471-4159.2001.00512.X  1
2000 Ostrerova-Golts N, Petrucelli L, Hardy J, Lee JM, Farer M, Wolozin B. The A53T alpha-synuclein mutation increases iron-dependent aggregation and toxicity. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 20: 6048-54. PMID 10934254  1
2000 Ostrerova-Golts N, Petrucelli L, Hardy J, Lee JM, Farer M, Wolozin B. The A53T α-Synuclein Mutation Increases Iron-Dependent Aggregation and Toxicity The Journal of Neuroscience. 20: 6048-6054. DOI: 10.1523/Jneurosci.20-16-06048.2000  1
1999 Ostrerova N, Petrucelli L, Farrer M, Mehta N, Choi P, Hardy J, Wolozin B. alpha-Synuclein shares physical and functional homology with 14-3-3 proteins. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 19: 5782-91. PMID 10407019  1
1998 D'Aniello A, Lee JM, Petrucelli L, Di Fiore MM. Regional decreases of free D-aspartate levels in Alzheimer's disease. Neuroscience Letters. 250: 131-4. PMID 9697936 DOI: 10.1016/S0304-3940(98)00451-0  1
1996 D'Aniello A, Di Cosmo A, Di Cristo C, Annunziato L, Petrucelli L, Fisher G. Involvement of D-aspartic acid in the synthesis of testosterone in rat testes. Life Sciences. 59: 97-104. PMID 8699926 DOI: 10.1016/0024-3205(96)00266-4  1
1994 Petrucelli L, Fisher GH. D-aspartate and D-glutamate in microwaved versus conventionally heated milk. Journal of the American College of Nutrition. 13: 209-10. PMID 7911811 DOI: 10.1080/07315724.1994.10718397  1
1994 Fisher GH, Petrucelli L, Gardner C, Emory C, Frey WH, Amaducci L, Sorbi S, Sorrentino G, Borghi M, D'Aniello A. Free D-amino acids in human cerebrospinal fluid of Alzheimer disease, multiple sclerosis, and healthy control subjects. Molecular and Chemical Neuropathology / Sponsored by the International Society For Neurochemistry and the World Federation of Neurology and Research Groups On Neurochemistry and Cerebrospinal Fluid. 23: 115-24. PMID 7702702 DOI: 10.1007/Bf02815405  1
1993 D'Aniello A, Petrucelli L, Gardner C, Fisher G. Improved method for hydrolyzing proteins and peptides without inducing racemization and for determining their true D-amino acid content. Analytical Biochemistry. 213: 290-5. PMID 8238904 DOI: 10.1006/abio.1993.1423  1
1993 D'Aniello A, Vetere A, Petrucelli L. Further study on the specificity of D-amino acid oxidase and D-aspartate oxidase and time course for complete oxidation of D-amino acids. Comparative Biochemistry and Physiology. B, Comparative Biochemistry. 105: 731-4. PMID 8103425 DOI: 10.1016/0305-0491(93)90113-J  1
1993 D'Aniello A, D'Onofrio G, Pischetola M, D'Aniello G, Vetere A, Petrucelli L, Fisher GH. Biological role of D-amino acid oxidase and D-aspartate oxidase. Effects of D-amino acids. The Journal of Biological Chemistry. 268: 26941-9. PMID 7903300  1
1992 D'Aniello A, Vetere A, Fisher GH, Cusano G, Chavez M, Petrucelli L. Presence of D-alanine in proteins of normal and Alzheimer human brain. Brain Research. 592: 44-8. PMID 1450921 DOI: 10.1016/0006-8993(92)91656-Y  1
1992 Fisher GH, D'Aniello A, Vetere A, Cusano GP, Chávez M, Petrucelli L. Quantification of D-aspartate in normal and Alzheimer brains. Neuroscience Letters. 143: 215-8. PMID 1436669 DOI: 10.1016/0304-3940(92)90268-C  1
1973 Roppolo JR, Werner G, Whitsel BL, Dreyer DA, Petrucelli LM. Phencyclidine action on neural mechanisms of somesthesis. Neuropharmacology. 12: 417-31. PMID 4196641 DOI: 10.1016/0028-3908(73)90058-0  1
1972 Whitsel BL, Petrucelli LM, Ha H, Dreyer DA. The resorting of spinal afferents as antecedent to the body representation in the postcentral gyrus. Brain, Behavior and Evolution. 5: 303-41. PMID 4629567  1
1970 Whitsel BL, Petrucelli LM, Sapiro G, Ha H. Fiber sorting in the fasciculus gracilis of squirrel monkeys. Experimental Neurology. 29: 227-42. PMID 4994110 DOI: 10.1016/0014-4886(70)90054-3  1
1969 Innes JR, Ulland BM, Valerio MG, Petrucelli L, Fishbein L, Hart ER, Pallotta AJ, Bates RR, Falk HL, Gart JJ, Klein M, Mitchell I, Peters J. Bioassay of pesticides and industrial chemicals for tumorigenicity in mice: a preliminary note. Journal of the National Cancer Institute. 42: 1101-14. PMID 5793189  1
1969 Whitsel BL, Petrucelli LM, Werner G. Symmetry and connectivity in the map of the body surface in somatosensory area II of primates. Journal of Neurophysiology. 32: 170-83. PMID 4975532  1
1969 Whitsel BL, Petrucelli LM, Sapiro G. Modality representation in the lumbar and cervical fasciculus gracilis of squirrel monkeys. Brain Research. 15: 67-78. PMID 4241233 DOI: 10.1016/0006-8993(69)90310-2  1
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