| Year |
Citation |
Score |
| 2023 |
Braxton JR, Altobelli CR, Tucker MR, Tse E, Thwin AC, Arkin MR, Southworth DR. The p97/VCP adaptor UBXD1 drives AAA+ remodeling and ring opening through multi-domain tethered interactions. Nature Structural & Molecular Biology. PMID 37945741 DOI: 10.1038/s41594-023-01126-0 |
0.788 |
|
| 2023 |
Jiang Z, Kuo YH, Arkin MR. Synthetic autophagy receptor. Autophagy. PMID 37934826 DOI: 10.1080/15548627.2023.2278954 |
0.651 |
|
| 2023 |
Jiang Z, Kuo YH, Arkin MR. Autophagy Receptor-Inspired Antibody-Fusion Proteins for Targeted Intracellular Degradation. Journal of the American Chemical Society. 145: 23939-23947. PMID 37748140 DOI: 10.1021/jacs.3c05199 |
0.645 |
|
| 2023 |
Braxton JR, Altobelli CR, Tucker MR, Tse E, Thwin AC, Arkin MR, Southworth DR. The p97/VCP adapter UBXD1 drives AAA+ remodeling and ring opening through multi-domain tethered interactions. Biorxiv : the Preprint Server For Biology. PMID 37292947 DOI: 10.1101/2023.05.15.540864 |
0.784 |
|
| 2023 |
Van Horn KS, Wang D, Medina-Cleghorn D, Lee PS, Bryant C, Altobelli C, Jaishankar P, Leung KK, Ng RA, Ambrose AJ, Tang Y, Arkin MR, Renslo AR. Engaging a Non-catalytic Cysteine Residue Drives Potent and Selective Inhibition of Caspase-6. Journal of the American Chemical Society. PMID 37104712 DOI: 10.1021/jacs.2c12240 |
0.761 |
|
| 2022 |
Tang Y, Kay A, Jiang Z, Arkin MR. LC3B Binds to the Autophagy Protease ATG4b with High Affinity Using a Bipartite Interface. Biochemistry. 61: 2295-2302. PMID 36264309 DOI: 10.1021/acs.biochem.2c00482 |
0.716 |
|
| 2022 |
Jiang Z, Kuo YH, Zhong M, Zhang J, Zhou XX, Xing L, Wells JA, Wang Y, Arkin MR. Adaptor-Specific Antibody Fragment Inhibitors for the Intracellular Modulation of p97 (VCP) Protein-Protein Interactions. Journal of the American Chemical Society. PMID 35819848 DOI: 10.1021/jacs.2c03665 |
0.727 |
|
| 2022 |
Chin MY, Ang KH, Davies J, Alquezar C, Garda VG, Rooney B, Leng K, Kampmann M, Arkin MR, Kao AW. Phenotypic Screening Using High-Content Imaging to Identify Lysosomal pH Modulators in a Neuronal Cell Model. Acs Chemical Neuroscience. 13: 1505-1516. PMID 35522480 DOI: 10.1021/acschemneuro.1c00804 |
0.569 |
|
| 2021 |
Sijbesma E, Hallenbeck KK, Andrei SA, Rust RR, Adriaans JMC, Brunsveld L, Arkin MR, Ottmann C. Exploration of a 14-3-3 PPI Pocket by Covalent Fragments as Stabilizers. Acs Medicinal Chemistry Letters. 12: 976-982. PMID 34136078 DOI: 10.1021/acsmedchemlett.1c00088 |
0.767 |
|
| 2021 |
Chin MY, Patwardhan AR, Ang KH, Wang AL, Alquezar C, Welch M, Nguyen PT, Grabe M, Molofsky AV, Arkin MR, Kao AW. Genetically Encoded, pH-Sensitive mTFP1 Biosensor for Probing Lysosomal pH. Acs Sensors. PMID 34102054 DOI: 10.1021/acssensors.0c02318 |
0.528 |
|
| 2020 |
Abdel Aziz MH, Fan Y, Liu L, Moasser M, Fu H, Jura N, Arkin MR. Expression and Purification of Active Human Kinases Using Pichia pastoris as A General-Purpose Host. Protein Expression and Purification. 105780. PMID 33115654 DOI: 10.1016/j.pep.2020.105780 |
0.74 |
|
| 2020 |
Blay V, Tolani B, Ho SP, Arkin MR. High-Throughput Screening: today's biochemical and cell-based approaches. Drug Discovery Today. PMID 32801051 DOI: 10.1016/J.Drudis.2020.07.024 |
0.313 |
|
| 2020 |
Mendiola AS, Ryu JK, Bardehle S, Meyer-Franke A, Ang KK, Wilson C, Baeten KM, Hanspers K, Merlini M, Thomas S, Petersen MA, Williams A, Thomas R, Rafalski VA, Meza-Acevedo R, ... ... Arkin MR, et al. Author Correction: Transcriptional profiling and therapeutic targeting of oxidative stress in neuroinflammation. Nature Immunology. PMID 32661365 DOI: 10.1038/S41590-020-0754-X |
0.606 |
|
| 2020 |
Leandro J, Khamrui S, Wang H, Suebsuwong C, Nemeria NS, Huynh K, Moustakim M, Secor C, Wang M, Dodatko T, Stauffer B, Wilson CG, Yu C, Arkin MR, Jordan F, et al. Inhibition and Crystal Structure of the Human DHTKD1-Thiamin Diphosphate Complex. Acs Chemical Biology. PMID 32633484 DOI: 10.1021/Acschembio.0C00114 |
0.33 |
|
| 2020 |
Guillory X, Wolter M, Leysen S, Neves JF, Kuusk A, Genet S, Somsen B, Morrow J, Rivers E, van Beek L, Patel J, Goodnow R, Schoenherr H, Fuller N, Cao Q, ... ... Arkin MR, et al. Fragment-based Differential Targeting of PPI Stabilizer Interfaces. Journal of Medicinal Chemistry. PMID 32501690 DOI: 10.1021/Acs.Jmedchem.9B01942 |
0.371 |
|
| 2020 |
Mendiola AS, Ryu JK, Bardehle S, Meyer-Franke A, Ang KK, Wilson C, Baeten KM, Hanspers K, Merlini M, Thomas S, Petersen MA, Williams A, Thomas R, Rafalski VA, Meza-Acevedo R, ... ... Arkin MR, et al. Transcriptional profiling and therapeutic targeting of oxidative stress in neuroinflammation. Nature Immunology. PMID 32284594 DOI: 10.1038/S41590-020-0654-0 |
0.617 |
|
| 2020 |
Chen X, Li Y, Wang C, Tang Y, Mok SA, Tsai RM, Rojas JC, Karydas A, Miller BL, Boxer AL, Gestwicki JE, Arkin M, Cuervo AM, Gan L. Promoting tau secretion and propagation by hyperactive p300/CBP via autophagy-lysosomal pathway in tauopathy. Molecular Neurodegeneration. 15: 2. PMID 31906970 DOI: 10.1186/S13024-019-0354-0 |
0.468 |
|
| 2019 |
Sanchez MI, de Vries LE, Lehmann C, Lee JT, Ang KK, Wilson C, Chen S, Arkin MR, Bogyo M, Deu E. Identification of Plasmodium dipeptidyl aminopeptidase allosteric inhibitors by high throughput screening. Plos One. 14: e0226270. PMID 31851699 DOI: 10.1371/Journal.Pone.0226270 |
0.383 |
|
| 2019 |
Walhart T, Isaacson-Wechsler E, Ang KH, Arkin M, Tugizov S, Palefsky JM. A Cell-Based Luminescence Reporter Plasmid Assay for High-Throughput Screening to Identify Novel FDA-Approved Drug Inhibitors of HPV-16 Infection. Slas Discovery : Advancing Life Sciences R & D. 2472555219860771. PMID 31361520 DOI: 10.1177/2472555219860771 |
0.509 |
|
| 2019 |
Ravalin M, Theofilas P, Basu K, Opoku-Nsiah KA, Assimon VA, Medina-Cleghorn D, Chen YF, Bohn MF, Arkin M, Grinberg LT, Craik CS, Gestwicki JE. Specificity for latent C termini links the E3 ubiquitin ligase CHIP to caspases. Nature Chemical Biology. 15: 786-794. PMID 31320752 DOI: 10.1038/S41589-019-0322-6 |
0.786 |
|
| 2019 |
Zhong M, Lee GM, Sijbesma E, Ottmann C, Arkin MR. Modulating protein-protein interaction networks in protein homeostasis. Current Opinion in Chemical Biology. 50: 55-65. PMID 30913483 DOI: 10.1016/J.Cbpa.2019.02.012 |
0.327 |
|
| 2019 |
Sijbesma E, Hallenbeck KK, Leysen S, de Vink P, Skora L, Jahnke W, Brunsveld L, Arkin MR, Ottmann C. Site-Directed Fragment-based Screening for the Discovery of Protein-Protein Interaction Stabilizers. Journal of the American Chemical Society. PMID 30707565 DOI: 10.1021/Jacs.8B11658 |
0.783 |
|
| 2018 |
LaPorte MG, Burnett JC, Colombo R, Bulfer SL, Alverez C, Chou TF, Neitz RJ, Green N, Moore WJ, Yue Z, Li S, Arkin MR, Wipf P, Huryn DM. Optimization of Phenyl Indole Inhibitors of the AAA+ ATPase p97. Acs Medicinal Chemistry Letters. 9: 1075-1081. PMID 30429948 DOI: 10.1021/Acsmedchemlett.8B00372 |
0.775 |
|
| 2018 |
Laurie MT, White CV, Retallack H, Wu W, Moser MS, Sakanari JA, Ang K, Wilson C, Arkin MR, DeRisi JL. Functional Assessment of 2,177 U.S. and International Drugs Identifies the Quinoline Nitroxoline as a Potent Amoebicidal Agent against the Pathogen . Mbio. 9. PMID 30377287 DOI: 10.1128/Mbio.02051-18 |
0.301 |
|
| 2018 |
Ryu JK, Rafalski VA, Meyer-Franke A, Adams RA, Poda SB, Rios Coronado PE, Pedersen LØ, Menon V, Baeten KM, Sikorski SL, Bedard C, Hanspers K, Bardehle S, Mendiola AS, Davalos D, ... ... Arkin MR, et al. Fibrin-targeting immunotherapy protects against neuroinflammation and neurodegeneration. Nature Immunology. PMID 30323343 DOI: 10.1038/S41590-018-0232-X |
0.765 |
|
| 2018 |
El-Sakkary N, Chen S, Arkin MR, Caffrey CR, Ribeiro P. Octopamine-signaling in the metazoan pathogen, : localization, small-molecule screening and opportunities for drug development. Disease Models & Mechanisms. PMID 29925529 DOI: 10.1242/Dmm.033563 |
0.302 |
|
| 2018 |
Markossian S, Ang KK, Wilson CG, Arkin MR. Small-Molecule Screening for Genetic Diseases. Annual Review of Genomics and Human Genetics. PMID 29799800 DOI: 10.1146/Annurev-Genom-083117-021452 |
0.316 |
|
| 2018 |
Wertz I, Kategaya L, Lello PD, Rouge L, Pastor R, Clark KR, Drummond J, Kleinheinz T, Lin E, Upton J, Prakash S, Heideker J, McCleland M, Ritorto MS, Alessi DR, ... ... Arkin MR, et al. Abstract SY23-03: Development and mechanistic characterization of USP7 deubiquitinase inhibitors Cancer Research. 78. DOI: 10.1158/1538-7445.Am2018-Sy23-03 |
0.578 |
|
| 2017 |
Kategaya L, Di Lello P, Rougé L, Pastor R, Clark KR, Drummond J, Kleinheinz T, Lin E, Upton JP, Prakash S, Heideker J, McCleland M, Ritorto MS, Alessi DR, Trost M, ... ... Arkin MR, et al. USP7 small-molecule inhibitors interfere with ubiquitin binding. Nature. PMID 29045385 DOI: 10.1038/Nature24006 |
0.582 |
|
| 2017 |
Theofilas P, Ehrenberg AJ, Nguy A, Thackrey JM, Dunlop S, Mejia MB, Alho AT, Paraizo Leite RE, Rodriguez RD, Suemoto CK, Nascimento CF, Chin M, Medina-Cleghorn D, Cuervo AM, Arkin M, et al. Probing the correlation of neuronal loss, neurofibrillary tangles, and cell death markers across the Alzheimer's disease Braak stages: a quantitative study in humans. Neurobiology of Aging. 61: 1-12. PMID 29031088 DOI: 10.1016/J.Neurobiolaging.2017.09.007 |
0.755 |
|
| 2017 |
Hallenbeck KK, Davies JL, Merron C, Ogden P, Sijbesma E, Ottmann C, Renslo AR, Wilson C, Arkin MR. A Liquid Chromatography/Mass Spectrometry Method for Screening Disulfide Tethering Fragments. Slas Discovery. 2472555217732072. PMID 28945980 DOI: 10.1177/2472555217732072 |
0.753 |
|
| 2017 |
Carlson HK, Mullan MR, Mosqueda LA, Chen S, Arkin MR, Coates JD. High-throughput screening to identify potent and specific inhibitors of microbial sulfate reduction. Environmental Science & Technology. PMID 28492331 DOI: 10.1021/Acs.Est.7B00686 |
0.334 |
|
| 2017 |
Burnett JC, Lim C, Peyser BD, Samankumara LP, Kovaliov M, Colombo R, Bulfer SL, LaPorte MG, Hermone AR, McGrath CF, Arkin MR, Gussio R, Huryn DM, Wipf P. A threonine turnstile defines a dynamic amphiphilic binding motif in the AAA ATPase p97 allosteric binding site. Organic & Biomolecular Chemistry. PMID 28352916 DOI: 10.1039/C7Ob00526A |
0.769 |
|
| 2016 |
Visperas PR, Wilson CG, Winger JA, Yan Q, Lin K, Arkin MR, Weiss A, Kuriyan J. Identification of Inhibitors of the Association of ZAP-70 with the T Cell Receptor by High-Throughput Screen. Journal of Biomolecular Screening. PMID 27932698 DOI: 10.1177/1087057116681407 |
0.765 |
|
| 2016 |
Hallenbeck KK, Turner DM, Renslo AR, Arkin MR. Covalent Strategies in Structure-Guided Drug Discovery. Current Topics in Medicinal Chemistry. PMID 27449257 DOI: 10.2174/1568026616666160719163839 |
0.783 |
|
| 2016 |
Hallenbeck KK, Turner DM, Renslo AR, Arkin MR. Covalent Strategies in Structure-Guided Drug Discovery. Current Topics in Medicinal Chemistry. PMID 27448650 |
0.773 |
|
| 2016 |
Gallagher CM, Garri C, Cain EL, Ang KK, Wilson CG, Chen S, Hearn BR, Jaishankar P, Aranda-Diaz A, Arkin MR, Renslo AR, Walter P. Ceapins are a new class of unfolded protein response inhibitors, selectively targeting the ATF6α branch. Elife. 5. PMID 27435960 DOI: 10.7554/Elife.11878 |
0.613 |
|
| 2016 |
Bulfer SL, Chou TF, Arkin MR. p97 disease mutations modulate nucleotide-induced con-formation to alter protein-protein interactions. Acs Chemical Biology. PMID 27267671 DOI: 10.1021/Acschembio.6B00350 |
0.769 |
|
| 2016 |
Alverez C, Bulfer SL, Chakrasali R, Chimenti MS, Deshaies RJ, Green N, Kelly M, LaPorte MG, Lewis TS, Liang M, Moore WJ, Neitz RJ, Peshkov VA, Walters MA, Zhang F, ... Arkin MR, et al. Allosteric Indole Amide Inhibitors of p97: Identification of a Novel Probe of the Ubiquitin Pathway. Acs Medicinal Chemistry Letters. 7: 182-7. PMID 26985295 DOI: 10.1021/Acsmedchemlett.5B00396 |
0.783 |
|
| 2016 |
Banerjee S, Bartesaghi A, Merk A, Rao P, Bulfer SL, Yan Y, Green N, Mroczkowski B, Neitz RJ, Wipf P, Falconieri V, Deshaies RJ, Milne JL, Huryn D, Arkin M, et al. 2.3 Å resolution cryo-EM structure of human p97 and mechanism of allosteric inhibition. Science (New York, N.Y.). PMID 26822609 DOI: 10.1126/Science.Aad7974 |
0.774 |
|
| 2016 |
Visscher M, Arkin MR, Dansen TB. Covalent targeting of acquired cysteines in cancer. Current Opinion in Chemical Biology. 30: 61-7. PMID 26629855 DOI: 10.1016/J.Cbpa.2015.11.004 |
0.316 |
|
| 2016 |
Gallagher CM, Garri C, Cain EL, Ang KK, Wilson CG, Chen S, Hearn BR, Jaishankar P, Aranda-Diaz A, Arkin MR, Renslo AR, Walter P. Author response: Ceapins are a new class of unfolded protein response inhibitors, selectively targeting the ATF6α branch Elife. DOI: 10.7554/Elife.11878.029 |
0.313 |
|
| 2016 |
Alverez C, Bulfer SL, Chakrasali R, Chimenti MS, Deshaies RJ, Green N, Kelly M, LaPorte MG, Lewis TS, Liang M, Moore WJ, Neitz RJ, Peshkov VA, Walters MA, Zhang F, ... Arkin MR, et al. Allosteric Indole Amide Inhibitors of p97: Identification of a Novel Probe of the Ubiquitin Pathway Acs Medicinal Chemistry Letters. 7: 182-187. DOI: 10.1021/acsmedchemlett.5b00396 |
0.756 |
|
| 2015 |
Alverez C, Arkin MR, Bulfer SL, Colombo R, Kovaliov M, LaPorte MG, Lim C, Liang M, Moore WJ, Neitz RJ, Yan Y, Yue Z, Huryn DM, Wipf P. Structure-Activity Study of Bioisosteric Trifluoromethyl and Pentafluorosulfanyl Indole Inhibitors of the AAA ATPase p97. Acs Medicinal Chemistry Letters. 6: 1225-30. PMID 26713109 DOI: 10.1021/Acsmedchemlett.5B00364 |
0.761 |
|
| 2015 |
Suzawa M, Miranda DA, Ramos KA, Ang KK, Faivre EJ, Wilson CG, Caboni L, Arkin MR, Kim YS, Fletterick RJ, Diaz A, Schneekloth JS, Ingraham HA. A gene-expression screen identifies a non-toxic sumoylation inhibitor that Mimics SUMO-less human LRH-1 in liver. Elife. 4. PMID 26653140 DOI: 10.7554/Elife.09003 |
0.615 |
|
| 2015 |
Khare S, Roach SL, Barnes SW, Hoepfner D, Walker JR, Chatterjee AK, Neitz RJ, Arkin MR, McNamara CW, Ballard J, Lai Y, Fu Y, Molteni V, Yeh V, McKerrow JH, et al. Utilizing Chemical Genomics to Identify Cytochrome b as a Novel Drug Target for Chagas Disease. Plos Pathogens. 11: e1005058. PMID 26186534 DOI: 10.1371/Journal.Ppat.1005058 |
0.361 |
|
| 2015 |
Neitz RJ, Bryant C, Chen S, Gut J, Hugo Caselli E, Ponce S, Chowdhury S, Xu H, Arkin MR, Ellman JA, Renslo AR. Tetrafluorophenoxymethyl ketone cruzain inhibitors with improved pharmacokinetic properties as therapeutic leads for Chagas' disease. Bioorganic & Medicinal Chemistry Letters. 25: 4834-7. PMID 26144347 DOI: 10.1016/J.Bmcl.2015.06.066 |
0.378 |
|
| 2015 |
Pfaff SJ, Chimenti MS, Kelly MJ, Arkin MR. Biophysical methods for identifying fragment-based inhibitors of protein-protein interactions. Methods in Molecular Biology (Clifton, N.J.). 1278: 587-613. PMID 25859978 DOI: 10.1007/978-1-4939-2425-7_39 |
0.675 |
|
| 2015 |
Zhang X, Gui L, Zhang X, Bulfer SL, Sanghez V, Wong DE, Lee Y, Lehmann L, Lee JS, Shih PY, Lin HJ, Iacovino M, Weihl CC, Arkin MR, Wang Y, et al. Altered cofactor regulation with disease-associated p97/VCP mutations. Proceedings of the National Academy of Sciences of the United States of America. 112: E1705-14. PMID 25775548 DOI: 10.1073/Pnas.1418820112 |
0.759 |
|
| 2015 |
Tran K, Arkin MR, Beal PA. Tethering in RNA: an RNA-binding fragment discovery tool. Molecules (Basel, Switzerland). 20: 4148-61. PMID 25749683 DOI: 10.3390/Molecules20034148 |
0.317 |
|
| 2015 |
Bulman CA, Bidlow CM, Lustigman S, Cho-Ngwa F, Williams D, Rascón AA, Tricoche N, Samje M, Bell A, Suzuki B, Lim KC, Supakorndej N, Supakorndej P, Wolfe AR, Knudsen GM, ... ... Arkin M, et al. Repurposing auranofin as a lead candidate for treatment of lymphatic filariasis and onchocerciasis. Plos Neglected Tropical Diseases. 9: e0003534. PMID 25700363 DOI: 10.1371/Journal.Pntd.0003534 |
0.574 |
|
| 2015 |
Chimenti MS, Bulfer SL, Neitz RJ, Renslo AR, Jacobson MP, James TL, Arkin MR, Kelly MJ. A Fragment-Based Ligand Screen Against Part of a Large Protein Machine: The ND1 Domains of the AAA+ ATPase p97/VCP. Journal of Biomolecular Screening. 20: 788-800. PMID 25690569 DOI: 10.1177/1087057115570550 |
0.781 |
|
| 2015 |
Visperas PR, Winger JA, Horton TM, Shah NH, Aum DJ, Tao A, Barros T, Yan Q, Wilson CG, Arkin MR, Weiss A, Kuriyan J. Modification by covalent reaction or oxidation of cysteine residues in the tandem-SH2 domains of ZAP-70 and Syk can block phosphopeptide binding. The Biochemical Journal. 465: 149-61. PMID 25287889 DOI: 10.1042/Bj20140793 |
0.781 |
|
| 2015 |
Neitz RJ, Chen S, Supek F, Yeh V, Kellar D, Gut J, Bryant C, Gallardo-Godoy A, Molteni V, Roach SL, Khare S, Stinson M, Chatterjee AK, Robertson S, Renslo AR, ... Arkin M, et al. Lead identification to clinical candidate selection: drugs for Chagas disease. Journal of Biomolecular Screening. 20: 101-11. PMID 25281737 DOI: 10.1177/1087057114553103 |
0.334 |
|
| 2015 |
Alverez C, Arkin MR, Bulfer SL, Colombo R, Kovaliov M, Laporte MG, Lim C, Liang M, Moore WJ, Neitz RJ, Yan Y, Yue Z, Huryn DM, Wipf P. Structure-Activity Study of Bioisosteric Trifluoromethyl and Pentafluorosulfanyl Indole Inhibitors of the AAA ATPase p97 Acs Medicinal Chemistry Letters. 6: 1225-1230. DOI: 10.1021/acsmedchemlett.5b00364 |
0.752 |
|
| 2014 |
Rettenmaier TJ, Sadowsky JD, Thomsen ND, Chen SC, Doak AK, Arkin MR, Wells JA. A small-molecule mimic of a peptide docking motif inhibits the protein kinase PDK1. Proceedings of the National Academy of Sciences of the United States of America. 111: 18590-5. PMID 25518860 DOI: 10.1073/Pnas.1415365112 |
0.574 |
|
| 2014 |
Arkin MR, Tang Y, Wells JA. Small-molecule inhibitors of protein-protein interactions: progressing toward the reality. Chemistry & Biology. 21: 1102-14. PMID 25237857 DOI: 10.1016/J.Chembiol.2014.09.001 |
0.645 |
|
| 2014 |
Chou TF, Bulfer SL, Weihl CC, Li K, Lis LG, Walters MA, Schoenen FJ, Lin HJ, Deshaies RJ, Arkin MR. Specific inhibition of p97/VCP ATPase and kinetic analysis demonstrate interaction between D1 and D2 ATPase domains. Journal of Molecular Biology. 426: 2886-99. PMID 24878061 DOI: 10.1016/J.Jmb.2014.05.022 |
0.768 |
|
| 2014 |
Arkin MR, Ang KK, Chen S, Davies J, Merron C, Tang Y, Wilson CG, Renslo AR. UCSF Small Molecule Discovery Center: innovation, collaboration and chemical biology in the Bay Area. Combinatorial Chemistry & High Throughput Screening. 17: 333-42. PMID 24661212 DOI: 10.2174/1386207317666140323133841 |
0.499 |
|
| 2014 |
Flygare JA, Arkin MR. Inhibiting caspase-6 activation and catalytic activity for neurodegenerative diseases. Current Topics in Medicinal Chemistry. 14: 319-25. PMID 24283214 DOI: 10.2174/1568026613666131126224039 |
0.342 |
|
| 2014 |
Murray J, Giannetti AM, Steffek M, Gibbons P, Hearn BR, Cohen F, Tam C, Pozniak C, Bravo B, Lewcock J, Jaishankar P, Ly CQ, Zhao X, Tang Y, Chugha P, ... Arkin MR, et al. Tailoring small molecules for an allosteric site on procaspase-6. Chemmedchem. 9: 73-7, 2. PMID 24259468 DOI: 10.1002/Cmdc.201300424 |
0.548 |
|
| 2013 |
Wilson CG, Arkin MR. Probing structural adaptivity at PPI interfaces with small molecules. Drug Discovery Today. Technologies. 10: e501-8. PMID 24451641 DOI: 10.1016/J.Ddtec.2012.10.009 |
0.383 |
|
| 2013 |
Sun Y, Dong Z, Jin T, Ang KH, Huang M, Haston KM, Peng J, Zhong TP, Finkbeiner S, Weiss WA, Arkin MR, Jan LY, Guo S. Imaging-based chemical screening reveals activity-dependent neural differentiation of pluripotent stem cells. Elife. 2: e00508. PMID 24040509 DOI: 10.7554/Elife.00508 |
0.597 |
|
| 2013 |
Bagriantsev SN, Ang KH, Gallardo-Godoy A, Clark KA, Arkin MR, Renslo AR, Minor DL. A high-throughput functional screen identifies small molecule regulators of temperature- and mechano-sensitive K2P channels. Acs Chemical Biology. 8: 1841-51. PMID 23738709 DOI: 10.1021/Cb400289X |
0.606 |
|
| 2013 |
Choy JW, Bryant C, Calvet CM, Doyle PS, Gunatilleke SS, Leung SS, Ang KK, Chen S, Gut J, Oses-Prieto JA, Johnston JB, Arkin MR, Burlingame AL, Taunton J, Jacobson MP, et al. Chemical-biological characterization of a cruzain inhibitor reveals a second target and a mammalian off-target. Beilstein Journal of Organic Chemistry. 9: 15-25. PMID 23400640 DOI: 10.3762/Bjoc.9.3 |
0.402 |
|
| 2013 |
Sun Y, Dong Z, Jin T, Ang K, Huang M, Haston KM, Peng J, Zhong TP, Finkbeiner S, Weiss WA, Arkin MR, Jan LY, Guo S. Author response: Imaging-based chemical screening reveals activity-dependent neural differentiation of pluripotent stem cells Elife. DOI: 10.7554/Elife.00508.017 |
0.569 |
|
| 2013 |
Hong WX, Akutagawa J, Chen S, Arkin M, Braun BS. Abstract 5524: Library screen to rapidly determine activity against normal and mutant bone marrow progenitor cells. Cancer Research. 73: 5524-5524. DOI: 10.1158/1538-7445.Am2013-5524 |
0.336 |
|
| 2013 |
Murray J, Giannetti AM, Steffek M, Gibbons P, Hearn BR, Cohen F, Tam C, Pozniak C, Bravo B, Lewcock J, Jaishankar P, Ly CQ, Zhao X, Tang Y, Chugha P, ... Arkin MR, et al. Inside Cover: Tailoring Small Molecules for an Allosteric Site on Procaspase-6 (ChemMedChem 1/2014) Chemmedchem. 9: 2-2. DOI: 10.1002/Cmdc.201390058 |
0.463 |
|
| 2012 |
Heise CE, Murray J, Augustyn KE, Bravo B, Chugha P, Cohen F, Giannetti AM, Gibbons P, Hannoush RN, Hearn BR, Jaishankar P, Ly CQ, Shah K, Stanger K, Steffek M, ... ... Arkin MR, et al. Mechanistic and structural understanding of uncompetitive inhibitors of caspase-6. Plos One. 7: e50864. PMID 23227217 DOI: 10.1371/Journal.Pone.0050864 |
0.773 |
|
| 2012 |
Wu VM, Chen SC, Arkin MR, Reiter JF. Small molecule inhibitors of Smoothened ciliary localization and ciliogenesis. Proceedings of the National Academy of Sciences of the United States of America. 109: 13644-9. PMID 22864913 DOI: 10.1073/Pnas.1207170109 |
0.345 |
|
| 2012 |
Rogers KE, Keränen H, Durrant JD, Ratnam J, Doak A, Arkin MR, McCammon JA. Novel cruzain inhibitors for the treatment of Chagas' disease. Chemical Biology & Drug Design. 80: 398-405. PMID 22613098 DOI: 10.1111/J.1747-0285.2012.01416.X |
0.341 |
|
| 2012 |
Debnath A, Parsonage D, Andrade RM, He C, Cobo ER, Hirata K, Chen S, GarcÃa-Rivera G, Orozco E, MartÃnez MB, Gunatilleke SS, Barrios AM, Arkin MR, Poole LB, McKerrow JH, et al. A high-throughput drug screen for Entamoeba histolytica identifies a new lead and target. Nature Medicine. 18: 956-60. PMID 22610278 DOI: 10.1038/Nm.2758 |
0.304 |
|
| 2012 |
Hong WX, Chen S, Akutagawa J, Arkin M, Braun BS. An In Vitro Library Screen to Rapidly Determine Activity Against Normal and Mutant Bone Marrow Progenitor Cells Blood. 120: 4916-4916. DOI: 10.1182/Blood.V120.21.4916.4916 |
0.317 |
|
| 2011 |
Tang Y, Wells JA, Arkin MR. Structural and enzymatic insights into caspase-2 protein substrate recognition and catalysis. The Journal of Biological Chemistry. 286: 34147-54. PMID 21828056 DOI: 10.1074/Jbc.M111.247627 |
0.64 |
|
| 2011 |
De Muylder G, Ang KK, Chen S, Arkin MR, Engel JC, McKerrow JH. A screen against Leishmania intracellular amastigotes: comparison to a promastigote screen and identification of a host cell-specific hit. Plos Neglected Tropical Diseases. 5: e1253. PMID 21811648 DOI: 10.1371/Journal.Pntd.0001253 |
0.318 |
|
| 2011 |
Ang KK, Ratnam J, Gut J, Legac J, Hansell E, Mackey ZB, Skrzypczynska KM, Debnath A, Engel JC, Rosenthal PJ, McKerrow JH, Arkin MR, Renslo AR. Mining a cathepsin inhibitor library for new antiparasitic drug leads. Plos Neglected Tropical Diseases. 5: e1023. PMID 21572521 DOI: 10.1371/Journal.Pntd.0001023 |
0.351 |
|
| 2011 |
Ben Khalaf N, De Muylder G, Ratnam J, Kean-Hooi Ang K, Arkin M, McKerrow J, Chenik M. A high-throughput turbidometric assay for screening inhibitors of Leishmania major protein disulfide isomerase. Journal of Biomolecular Screening. 16: 545-51. PMID 21441416 DOI: 10.1177/1087057111401026 |
0.388 |
|
| 2011 |
Gut J, Ang KK, Legac J, Arkin MR, Rosenthal PJ, McKerrow JH. An image-based assay for high throughput screening of Giardia lamblia. Journal of Microbiological Methods. 84: 398-405. PMID 21262276 DOI: 10.1016/J.Mimet.2010.12.026 |
0.314 |
|
| 2011 |
Wilson CG, Arkin MR. Small-molecule inhibitors of IL-2/IL-2R: lessons learned and applied. Current Topics in Microbiology and Immunology. 348: 25-59. PMID 20703966 DOI: 10.1007/82_2010_93 |
0.311 |
|
| 2010 |
Engel JC, Ang KK, Chen S, Arkin MR, McKerrow JH, Doyle PS. Image-based high-throughput drug screening targeting the intracellular stage of Trypanosoma cruzi, the agent of Chagas' disease. Antimicrobial Agents and Chemotherapy. 54: 3326-34. PMID 20547819 DOI: 10.1128/Aac.01777-09 |
0.306 |
|
| 2010 |
Mott BT, Ferreira RS, Simeonov A, Jadhav A, Ang KK, Leister W, Shen M, Silveira JT, Doyle PS, Arkin MR, McKerrow JH, Inglese J, Austin CP, Thomas CJ, Shoichet BK, et al. Identification and optimization of inhibitors of Trypanosomal cysteine proteases: cruzain, rhodesain, and TbCatB. Journal of Medicinal Chemistry. 53: 52-60. PMID 19908842 DOI: 10.1021/Jm901069A |
0.353 |
|
| 2010 |
Arkin M. Finding Small Molecule Ligands for Protein-Protein Interactions and Other “Undruggable” Targets Biophysical Journal. 98: 411a. DOI: 10.1016/J.Bpj.2009.12.2216 |
0.382 |
|
| 2009 |
Bryant C, Kerr ID, Debnath M, Ang KK, Ratnam J, Ferreira RS, Jaishankar P, Zhao D, Arkin MR, McKerrow JH, Brinen LS, Renslo AR. Novel non-peptidic vinylsulfones targeting the S2 and S3 subsites of parasite cysteine proteases. Bioorganic & Medicinal Chemistry Letters. 19: 6218-21. PMID 19773167 DOI: 10.1016/J.Bmcl.2009.08.098 |
0.332 |
|
| 2009 |
Mckerrow JH, Doyle PS, Engel JC, Podust LM, Robertson SA, Ferreira R, Saxton T, Arkin M, Kerr ID, Brinen LS, Craik CS. Two approaches to discovering and developing new drugs for Chagas disease Memorias Do Instituto Oswaldo Cruz. 104: 263-269. PMID 19753483 DOI: 10.1590/S0074-02762009000900034 |
0.309 |
|
| 2009 |
Arkin MR, Whitty A. The road less traveled: modulating signal transduction enzymes by inhibiting their protein-protein interactions. Current Opinion in Chemical Biology. 13: 284-90. PMID 19553156 DOI: 10.1016/J.Cbpa.2009.05.125 |
0.356 |
|
| 2009 |
Rubio BK, Tenney K, Ang KH, Abdulla M, Arkin M, McKerrow JH, Crews P. The marine sponge Diacarnus bismarckensis as a source of peroxiterpene inhibitors of Trypanosoma brucei, the causative agent of sleeping sickness Journal of Natural Products. 72: 218-222. PMID 19159277 DOI: 10.1021/Np800711A |
0.568 |
|
| 2005 |
Arkin M. Protein-protein interactions and cancer: small molecules going in for the kill. Current Opinion in Chemical Biology. 9: 317-24. PMID 15939335 DOI: 10.1016/J.Cbpa.2005.03.001 |
0.383 |
|
| 2004 |
Raimundo BC, Oslob JD, Braisted AC, Hyde J, McDowell RS, Randal M, Waal ND, Wilkinson J, Yu CH, Arkin MR. Integrating fragment assembly and biophysical methods in the chemical advancement of small-molecule antagonists of IL-2: an approach for inhibiting protein-protein interactions. Journal of Medicinal Chemistry. 47: 3111-30. PMID 15163192 DOI: 10.1021/Jm049967U |
0.316 |
|
| 2004 |
Arkin MR, Wells JA. Small-molecule inhibitors of protein-protein interactions: progressing towards the dream. Nature Reviews. Drug Discovery. 3: 301-17. PMID 15060526 DOI: 10.1038/Nrd1343 |
0.532 |
|
| 2003 |
Hyde J, Braisted AC, Randal M, Arkin MR. Discovery and characterization of cooperative ligand binding in the adaptive region of interleukin-2. Biochemistry. 42: 6475-83. PMID 12767230 DOI: 10.2210/Pdb1Nbp/Pdb |
0.329 |
|
| 2003 |
Wells J, Arkin M, Braisted A, DeLano W, McDowell B, Oslob J, Raimundo B, Randal M. Drug discovery at signaling interfaces. Ernst Schering Research Foundation Workshop. 19-27. PMID 12664533 DOI: 10.1007/978-3-662-05314-0_3 |
0.374 |
|
| 2003 |
Braisted AC, Oslob JD, Delano WL, Hyde J, McDowell RS, Waal N, Yu C, Arkin MR, Raimundo BC. Discovery of a potent small molecule IL-2 inhibitor through fragment assembly. Journal of the American Chemical Society. 125: 3714-5. PMID 12656598 DOI: 10.1021/Ja034247I |
0.368 |
|
| 2003 |
Arkin MR, Randal M, DeLano WL, Hyde J, Luong TN, Oslob JD, Raphael DR, Taylor L, Wang J, McDowell RS, Wells JA, Braisted AC. Binding of small molecules to an adaptive protein-protein interface. Proceedings of the National Academy of Sciences of the United States of America. 100: 1603-8. PMID 12582206 DOI: 10.1073/Pnas.252756299 |
0.536 |
|
| 2001 |
Arkin M, Lear JD. A new data analysis method to determine binding constants of small molecules to proteins using equilibrium analytical ultracentrifugation with absorption optics Analytical Biochemistry. 299: 98-107. PMID 11726190 DOI: 10.1006/Abio.2001.5396 |
0.31 |
|
| 1998 |
Arkin MR, Wells JA. Probing the importance of second sphere residues in an esterolytic antibody by phage display Journal of Molecular Biology. 284: 1083-1094. PMID 9837728 DOI: 10.1006/Jmbi.1998.2234 |
0.497 |
|
| 1997 |
Arkin MR, Stemp ED, Pulver SC, Barton JK. Long-range oxidation of guanine by Ru(III) in duplex DNA. Chemistry & Biology. 4: 389-400. PMID 9195873 DOI: 10.1016/S1074-5521(97)90129-0 |
0.765 |
|
| 1997 |
Olson EJC, Hu D, Hörmann A, Jonkman AM, Arkin MR, Stemp EDA, Barton JK, Barbara PF. First observation of the key intermediate in the 'light-switch' mechanism of [Ru(phen)2dppz]2+ Journal of the American Chemical Society. 119: 11458-11467. DOI: 10.1021/Ja971151D |
0.549 |
|
| 1997 |
Stemp EDA, Arkin MR, Barton JK. Oxidation of guanine in DNA by Ru(phen)2(dppz)3+ using the flash-quench technique Journal of the American Chemical Society. 119: 2921-2925. DOI: 10.1021/Ja963606P |
0.571 |
|
| 1996 |
Arkin MR, Stemp ED, Holmlin RE, Barton JK, Hörmann A, Olson EJ, Barbara PF. Rates of DNA-mediated electron transfer between metallointercalators. Science (New York, N.Y.). 273: 475-80. PMID 8662532 DOI: 10.1126/Science.273.5274.475 |
0.775 |
|
| 1996 |
Arkin MR, Stemp EDA, Turro C, Turro NJ, Barton JK. Luminescence quenching in supramolecular systems: A comparison of DNA- and SDS micelle-mediated photoinduced electron transfer between metal complexes Journal of the American Chemical Society. 118: 2267-2274. DOI: 10.1021/Ja9532998 |
0.578 |
|
| 1996 |
Hörmann A, Olson EJC, Barbara PF, Arkin MR, Stemp EDA, Holmlin RE, Barton JK. Time resolved electron transfer studies between metallointercalators in DNA Springer Series in Chemical Physics. 62: 359-360. |
0.517 |
|
| 1995 |
Stemp EDA, Arkin MR, Barton JK. Electron transfer between metallointercalators bound to DNA: Spectral identification of the transient intermediate Journal of the American Chemical Society. 117: 2375-2376. DOI: 10.1021/Ja00113A037 |
0.572 |
|
| 1995 |
Arkin MR, Stemp ED, Holmin R, Hoermann A, Olson E, Barbara PF, Barton JK. Rates of electron transfer reactions between metallointercalators Journal of Inorganic Biochemistry. 59: 266. DOI: 10.1016/0162-0134(95)97369-2 |
0.749 |
|
| 1995 |
Barton JK, Arkin MR, Stemp ED, Holmlin R, Jenkins Y. DNA-mediated electron transfer Journal of Inorganic Biochemistry. 59: 132. DOI: 10.1016/0162-0134(95)97240-Q |
0.761 |
|
| 1994 |
Murphy CJ, Arkin MR, Ghatlia ND, Bossmann S, Turro NJ, Barton JK. Fast photoinduced electron transfer through DNA intercalation. Proceedings of the National Academy of Sciences of the United States of America. 91: 5315-9. PMID 8202486 DOI: 10.1073/Pnas.91.12.5315 |
0.644 |
|
| 1993 |
Murphy CJ, Arkin MR, Jenkins Y, Ghatlia ND, Bossmann SH, Turro NJ, Barton JK. Long-range photoinduced electron transfer through a DNA helix. Science (New York, N.Y.). 262: 1025-9. PMID 7802858 DOI: 10.1126/Science.7802858 |
0.648 |
|
| 1993 |
Arkin M, Murphy C, Jenkins Y, Turro N, Barton J. Evidence for photoelectron transfer through DNA intercalation Journal of Inorganic Biochemistry. 51: 526. DOI: 10.1016/0162-0134(93)85552-J |
0.628 |
|
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