William Klein, PhD - Publications

Affiliations: 
Neurobiology and Physiology Northwestern University, Evanston, IL 

108 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2016 Savioz A, Giannakopoulos P, Herrmann FR, Klein WL, Kövari E, Bouras C, Giacobini E. A Study of Aβ Oligomers in the Temporal Cortex and Cerebellum of Patients with Neuropathologically Confirmed Alzheimer's Disease Compared to Aged Controls. Neuro-Degenerative Diseases. 16: 398-406. PMID 27400224 DOI: 10.1159/000446283  1
2015 Wilcox KC, Marunde MR, Das A, Velasco PT, Kuhns BD, Marty MT, Jiang H, Luan CH, Sligar SG, Klein WL. Nanoscale Synaptic Membrane Mimetic Allows Unbiased High Throughput Screen That Targets Binding Sites for Alzheimer's-Associated Aβ Oligomers. Plos One. 10: e0125263. PMID 25928376 DOI: 10.1371/journal.pone.0125263  1
2015 Baker-Nigh A, Vahedi S, Davis EG, Weintraub S, Bigio EH, Klein WL, Geula C. Neuronal amyloid-β accumulation within cholinergic basal forebrain in ageing and Alzheimer's disease. Brain : a Journal of Neurology. 138: 1722-37. PMID 25732182 DOI: 10.1093/brain/awv024  1
2015 Clarke JR, Lyra E Silva NM, Figueiredo CP, Frozza RL, Ledo JH, Beckman D, Katashima CK, Razolli D, Carvalho BM, Frazão R, Silveira MA, Ribeiro FC, Bomfim TR, Neves FS, Klein WL, et al. Alzheimer-associated Aβ oligomers impact the central nervous system to induce peripheral metabolic deregulation. Embo Molecular Medicine. 7: 190-210. PMID 25617315 DOI: 10.15252/emmm.201404183  1
2015 Viola KL, Klein WL. Amyloid β oligomers in Alzheimer's disease pathogenesis, treatment, and diagnosis. Acta Neuropathologica. 129: 183-206. PMID 25604547 DOI: 10.1007/s00401-015-1386-3  1
2015 Viola KL, Sbarboro J, Sureka R, De M, Bicca MA, Wang J, Vasavada S, Satpathy S, Wu S, Joshi H, Velasco PT, MacRenaris K, Waters EA, Lu C, Phan J, ... ... Klein WL, et al. Towards non-invasive diagnostic imaging of early-stage Alzheimer's disease. Nature Nanotechnology. 10: 91-8. PMID 25531084 DOI: 10.1038/nnano.2014.254  1
2015 Knight EM, Williams HN, Stevens AC, Kim SH, Kottwitz JC, Morant AD, Steele JW, Klein WL, Yanagisawa K, Boyd RE, Lockhart DJ, Sjoberg ER, Ehrlich ME, Wustman BA, Gandy S. Evidence that small molecule enhancement of β-hexosaminidase activity corrects the behavioral phenotype in Dutch APP(E693Q) mice through reduction of ganglioside-bound Aβ. Molecular Psychiatry. 20: 109-17. PMID 25349165 DOI: 10.1038/mp.2014.135  1
2014 Sebollela A, Mustata GM, Luo K, Velasco PT, Viola KL, Cline EN, Shekhawat GS, Wilcox KC, Dravid VP, Klein WL. Elucidating molecular mass and shape of a neurotoxic Aβ oligomer. Acs Chemical Neuroscience. 5: 1238-45. PMID 25343357 DOI: 10.1021/cn500156r  1
2014 Forny-Germano L, Lyra e Silva NM, Batista AF, Brito-Moreira J, Gralle M, Boehnke SE, Coe BC, Lablans A, Marques SA, Martinez AM, Klein WL, Houzel JC, Ferreira ST, Munoz DP, De Felice FG. Alzheimer's disease-like pathology induced by amyloid-β oligomers in nonhuman primates. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 34: 13629-43. PMID 25297091 DOI: 10.1523/JNEUROSCI.1353-14.2014  1
2014 Heffern MC, Velasco PT, Matosziuk LM, Coomes JL, Karras C, Ratner MA, Klein WL, Eckermann AL, Meade TJ. Modulation of amyloid-β aggregation by histidine-coordinating Cobalt(III) Schiff base complexes. Chembiochem : a European Journal of Chemical Biology. 15: 1584-9. PMID 24961930 DOI: 10.1002/cbic.201402201  1
2014 Iulita MF, Allard S, Richter L, Munter LM, Ducatenzeiler A, Weise C, Do Carmo S, Klein WL, Multhaup G, Cuello AC. Intracellular Aβ pathology and early cognitive impairments in a transgenic rat overexpressing human amyloid precursor protein: a multidimensional study. Acta Neuropathologica Communications. 2: 61. PMID 24903713 DOI: 10.1186/2051-5960-2-61  1
2014 Blair JA, Siedlak SL, Wolfram JA, Nunomura A, Castellani RJ, Ferreira ST, Klein WL, Wang Y, Casadesus G, Smith MA, Perry G, Zhu X, Lee HG. Accumulation of intraneuronal amyloid-β is common in normal brain. Current Alzheimer Research. 11: 317-24. PMID 24597504 DOI: 10.2174/1567205011666140302200902  1
2013 Lourenco MV, Clarke JR, Frozza RL, Bomfim TR, Forny-Germano L, Batista AF, Sathler LB, Brito-Moreira J, Amaral OB, Silva CA, Freitas-Correa L, Espírito-Santo S, Campello-Costa P, Houzel JC, Klein WL, et al. TNF-α mediates PKR-dependent memory impairment and brain IRS-1 inhibition induced by Alzheimer's β-amyloid oligomers in mice and monkeys. Cell Metabolism. 18: 831-43. PMID 24315369 DOI: 10.1016/j.cmet.2013.11.002  1
2013 Kam TI, Song S, Gwon Y, Park H, Yan JJ, Im I, Choi JW, Choi TY, Kim J, Song DK, Takai T, Kim YC, Kim KS, Choi SY, Choi S, ... Klein WL, et al. FcγRIIb mediates amyloid-β neurotoxicity and memory impairment in Alzheimer's disease. The Journal of Clinical Investigation. 123: 2791-802. PMID 23921129 DOI: 10.1172/JCI66827  1
2013 Figueiredo CP, Clarke JR, Ledo JH, Ribeiro FC, Costa CV, Melo HM, Mota-Sales AP, Saraiva LM, Klein WL, Sebollela A, De Felice FG, Ferreira ST. Memantine rescues transient cognitive impairment caused by high-molecular-weight aβ oligomers but not the persistent impairment induced by low-molecular-weight oligomers. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 33: 9626-34. PMID 23739959 DOI: 10.1523/JNEUROSCI.0482-13.2013  1
2013 Lithner CU, Lacor PN, Zhao WQ, Mustafiz T, Klein WL, Sweatt JD, Hernandez CM. Disruption of neocortical histone H3 homeostasis by soluble Aβ: implications for Alzheimer's disease. Neurobiology of Aging. 34: 2081-90. PMID 23582659 DOI: 10.1016/j.neurobiolaging.2012.12.028  1
2013 Xiao C, Davis FJ, Chauhan BC, Viola KL, Lacor PN, Velasco PT, Klein WL, Chauhan NB. Brain transit and ameliorative effects of intranasally delivered anti-amyloid-β oligomer antibody in 5XFAD mice. Journal of Alzheimer's Disease : Jad. 35: 777-88. PMID 23542865 DOI: 10.3233/JAD-122419  1
2013 Kondo T, Asai M, Tsukita K, Kutoku Y, Ohsawa Y, Sunada Y, Imamura K, Egawa N, Yahata N, Okita K, Takahashi K, Asaka I, Aoi T, Watanabe A, Watanabe K, ... ... Klein WL, et al. Modeling Alzheimer's disease with iPSCs reveals stress phenotypes associated with intracellular Aβ and differential drug responsiveness. Cell Stem Cell. 12: 487-96. PMID 23434393 DOI: 10.1016/j.stem.2013.01.009  1
2013 Marty MT, Wilcox KC, Klein WL, Sligar SG. Nanodisc-solubilized membrane protein library reflects the membrane proteome. Analytical and Bioanalytical Chemistry. 405: 4009-16. PMID 23400332 DOI: 10.1007/s00216-013-6790-8  1
2013 Pitt J, Thorner M, Brautigan D, Larner J, Klein WL. Protection against the synaptic targeting and toxicity of Alzheimer's-associated Aβ oligomers by insulin mimetic chiro-inositols. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 27: 199-207. PMID 23073831 DOI: 10.1096/fj.12-211896  1
2013 Klein WL. Synaptotoxic amyloid-β oligomers: a molecular basis for the cause, diagnosis, and treatment of Alzheimer's disease? Journal of Alzheimer's Disease : Jad. 33: S49-65. PMID 22785404 DOI: 10.3233/JAD-2012-129039  1
2012 Velasco PT, Heffern MC, Sebollela A, Popova IA, Lacor PN, Lee KB, Sun X, Tiano BN, Viola KL, Eckermann AL, Meade TJ, Klein WL. Synapse-binding subpopulations of Aβ oligomers sensitive to peptide assembly blockers and scFv antibodies. Acs Chemical Neuroscience. 3: 972-81. PMID 23173076 DOI: 10.1021/cn300122k  1
2012 Bitel CL, Kasinathan C, Kaswala RH, Klein WL, Frederikse PH. Amyloid-β and tau pathology of Alzheimer's disease induced by diabetes in a rabbit animal model. Journal of Alzheimer's Disease : Jad. 32: 291-305. PMID 22785400 DOI: 10.3233/JAD-2012-120571  1
2012 Costa RO, Lacor PN, Ferreira IL, Resende R, Auberson YP, Klein WL, Oliveira CR, Rego AC, Pereira CM. Endoplasmic reticulum stress occurs downstream of GluN2B subunit of N-methyl-d-aspartate receptor in mature hippocampal cultures treated with amyloid-β oligomers. Aging Cell. 11: 823-33. PMID 22708890 DOI: 10.1111/j.1474-9726.2012.00848.x  1
2012 Nunes-Tavares N, Santos LE, Stutz B, Brito-Moreira J, Klein WL, Ferreira ST, de Mello FG. Inhibition of choline acetyltransferase as a mechanism for cholinergic dysfunction induced by amyloid-β peptide oligomers. The Journal of Biological Chemistry. 287: 19377-85. PMID 22505713 DOI: 10.1074/jbc.M111.321448  1
2012 Bomfim TR, Forny-Germano L, Sathler LB, Brito-Moreira J, Houzel JC, Decker H, Silverman MA, Kazi H, Melo HM, McClean PL, Holscher C, Arnold SE, Talbot K, Klein WL, Munoz DP, et al. An anti-diabetes agent protects the mouse brain from defective insulin signaling caused by Alzheimer's disease- associated Aβ oligomers. The Journal of Clinical Investigation. 122: 1339-53. PMID 22476196 DOI: 10.1172/JCI57256  1
2012 Zhou Y, Klein WL. Aβ oligomers-induced toxicity is attenuated in cells cultured with NbActiv4â„¢ medium. Neurotoxicity Research. 22: 335-44. PMID 22441766 DOI: 10.1007/s12640-012-9318-7  1
2012 Umeda T, Tomiyama T, Kitajima E, Idomoto T, Nomura S, Lambert MP, Klein WL, Mori H. Hypercholesterolemia accelerates intraneuronal accumulation of Aβ oligomers resulting in memory impairment in Alzheimer's disease model mice. Life Sciences. 91: 1169-76. PMID 22273754 DOI: 10.1016/j.lfs.2011.12.022  1
2012 Soura V, Stewart-Parker M, Williams TL, Ratnayaka A, Atherton J, Gorringe K, Tuffin J, Darwent E, Rambaran R, Klein W, Lacor P, Staras K, Thorpe J, Serpell LC. Visualization of co-localization in Aβ42-administered neuroblastoma cells reveals lysosome damage and autophagosome accumulation related to cell death. The Biochemical Journal. 441: 579-90. PMID 21955321 DOI: 10.1042/BJ20110749  1
2012 Bao F, Wicklund L, Lacor PN, Klein WL, Nordberg A, Marutle A. Different β-amyloid oligomer assemblies in Alzheimer brains correlate with age of disease onset and impaired cholinergic activity. Neurobiology of Aging. 33: 825.e1-13. PMID 21683475 DOI: 10.1016/j.neurobiolaging.2011.05.003  1
2012 Ferretti MT, Bruno MA, Ducatenzeiler A, Klein WL, Cuello AC. Intracellular Aβ-oligomers and early inflammation in a model of Alzheimer's disease. Neurobiology of Aging. 33: 1329-42. PMID 21414686 DOI: 10.1016/j.neurobiolaging.2011.01.007  1
2012 Klein WL. Synaptotoxic amyloid-β oligomers: A molecular basis for the cause, diagnosis, and treatment of Alzheimer's disease? Advances in Alzheimer's Disease. 3: 49-65. DOI: 10.3233/978-1-61499-154-0-49  1
2012 Mustata GM, Shekhawat GS, Lambert MP, Viola KL, Velasco PT, Klein WL, Dravid VP. Insights into the mechanism of Alzheimer's β-amyloid aggregation as a function of concentration by using atomic force microscopy Applied Physics Letters. 100. DOI: 10.1063/1.3697682  1
2012 Wilcox KC, Pitt J, Sebollela A, Martirosova H, Lacor PN, Klein WL. Biological targeting and activity of pre-fibrillar Aβ assemblies Non-Fibrillar Amyloidogenic Protein Assemblies - Common Cytotoxins Underlying Degenerative Diseases. 2147483647: 103-133. DOI: 10.1007/978-94-007-2774-8_4  1
2011 Ferreira ST, Klein WL. The Aβ oligomer hypothesis for synapse failure and memory loss in Alzheimer's disease. Neurobiology of Learning and Memory. 96: 529-43. PMID 21914486 DOI: 10.1016/j.nlm.2011.08.003  1
2011 Wilcox KC, Lacor PN, Pitt J, Klein WL. Aβ oligomer-induced synapse degeneration in Alzheimer's disease. Cellular and Molecular Neurobiology. 31: 939-48. PMID 21538118 DOI: 10.1007/s10571-011-9691-4  1
2011 Umeda T, Tomiyama T, Sakama N, Tanaka S, Lambert MP, Klein WL, Mori H. Intraneuronal amyloid β oligomers cause cell death via endoplasmic reticulum stress, endosomal/lysosomal leakage, and mitochondrial dysfunction in vivo. Journal of Neuroscience Research. 89: 1031-42. PMID 21488093 DOI: 10.1002/jnr.22640  1
2011 Ferretti MT, Partridge V, Leon WC, Canneva F, Allard S, Arvanitis DN, Vercauteren F, Houle D, Ducatenzeiler A, Klein WL, Glabe CG, Szyf M, Cuello AC. Transgenic mice as a model of pre-clinical Alzheimer's disease. Current Alzheimer Research. 8: 4-23. PMID 21143159 DOI: 10.2174/156720511794604561  1
2010 Saraiva LM, Seixas da Silva GS, Galina A, da-Silva WS, Klein WL, Ferreira ST, De Felice FG. Amyloid-β triggers the release of neuronal hexokinase 1 from mitochondria. Plos One. 5: e15230. PMID 21179577 DOI: 10.1371/journal.pone.0015230  1
2010 Decker H, Jürgensen S, Adrover MF, Brito-Moreira J, Bomfim TR, Klein WL, Epstein AL, De Felice FG, Jerusalinsky D, Ferreira ST. N-methyl-D-aspartate receptors are required for synaptic targeting of Alzheimer's toxic amyloid-β peptide oligomers. Journal of Neurochemistry. 115: 1520-9. PMID 20950339 DOI: 10.1111/j.1471-4159.2010.07058.x  1
2010 Nogalska A, D'Agostino C, Engel WK, Klein WL, Askanas V. Novel demonstration of amyloid-β oligomers in sporadic inclusion-body myositis muscle fibers. Acta Neuropathologica. 120: 661-6. PMID 20711838 DOI: 10.1007/s00401-010-0737-3  1
2010 Krafft GA, Klein WL. ADDLs and the signaling web that leads to Alzheimer's disease. Neuropharmacology. 59: 230-42. PMID 20650286 DOI: 10.1016/j.neuropharm.2010.07.012  1
2010 Renner M, Lacor PN, Velasco PT, Xu J, Contractor A, Klein WL, Triller A. Deleterious effects of amyloid beta oligomers acting as an extracellular scaffold for mGluR5. Neuron. 66: 739-54. PMID 20547131 DOI: 10.1016/j.neuron.2010.04.029  1
2010 Tomiyama T, Matsuyama S, Iso H, Umeda T, Takuma H, Ohnishi K, Ishibashi K, Teraoka R, Sakama N, Yamashita T, Nishitsuji K, Ito K, Shimada H, Lambert MP, Klein WL, et al. A mouse model of amyloid beta oligomers: their contribution to synaptic alteration, abnormal tau phosphorylation, glial activation, and neuronal loss in vivo. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 30: 4845-56. PMID 20371804 DOI: 10.1523/JNEUROSCI.5825-09.2010  1
2010 Leon WC, Canneva F, Partridge V, Allard S, Ferretti MT, DeWilde A, Vercauteren F, Atifeh R, Ducatenzeiler A, Klein W, Szyf M, Alhonen L, Cuello AC. A novel transgenic rat model with a full Alzheimer's-like amyloid pathology displays pre-plaque intracellular amyloid-beta-associated cognitive impairment. Journal of Alzheimer's Disease : Jad. 20: 113-26. PMID 20164597 DOI: 10.3233/JAD-2010-1349  1
2010 Wu Y, Cao Z, Klein WL, Luo Y. Heat shock treatment reduces beta amyloid toxicity in vivo by diminishing oligomers. Neurobiology of Aging. 31: 1055-8. PMID 18762355 DOI: 10.1016/j.neurobiolaging.2008.07.013  1
2009 Anker JN, Hall WP, Lambert MP, Velasco PT, Mrksich M, Klein WL, Van Duyne RP. Detection and Identification of Bioanalytes with High Resolution LSPR Spectroscopy and MALDI Mass Spectrometry. The Journal of Physical Chemistry. C, Nanomaterials and Interfaces. 113: 5891-5894. PMID 20161175 DOI: 10.1021/jp900266k  1
2009 Shekhawat GS, Lambert MP, Sharma S, Velasco PT, Viola KL, Klein WL, Dravid VP. Soluble state high resolution atomic force microscopy study of Alzheimer's beta-amyloid oligomers. Applied Physics Letters. 95: 183701. PMID 19997583 DOI: 10.1063/1.3251779  1
2009 Tchantchou F, Lacor PN, Cao Z, Lao L, Hou Y, Cui C, Klein WL, Luo Y. Stimulation of neurogenesis and synaptogenesis by bilobalide and quercetin via common final pathway in hippocampal neurons. Journal of Alzheimer's Disease : Jad. 18: 787-98. PMID 19661619 DOI: 10.3233/JAD-2009-1189  1
2009 Pitt J, Roth W, Lacor P, Smith AB, Blankenship M, Velasco P, De Felice F, Breslin P, Klein WL. Alzheimer's-associated Abeta oligomers show altered structure, immunoreactivity and synaptotoxicity with low doses of oleocanthal. Toxicology and Applied Pharmacology. 240: 189-97. PMID 19631677 DOI: 10.1016/j.taap.2009.07.018  1
2009 Peng S, Garzon DJ, Marchese M, Klein W, Ginsberg SD, Francis BM, Mount HT, Mufson EJ, Salehi A, Fahnestock M. Decreased brain-derived neurotrophic factor depends on amyloid aggregation state in transgenic mouse models of Alzheimer's disease. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 29: 9321-9. PMID 19625522 DOI: 10.1523/JNEUROSCI.4736-08.2009  1
2009 Kiyota T, Yamamoto M, Xiong H, Lambert MP, Klein WL, Gendelman HE, Ransohoff RM, Ikezu T. CCL2 accelerates microglia-mediated Abeta oligomer formation and progression of neurocognitive dysfunction. Plos One. 4: e6197. PMID 19593388 DOI: 10.1371/journal.pone.0006197  1
2009 Zhao WQ, Lacor PN, Chen H, Lambert MP, Quon MJ, Krafft GA, Klein WL. Insulin receptor dysfunction impairs cellular clearance of neurotoxic oligomeric a{beta}. The Journal of Biological Chemistry. 284: 18742-53. PMID 19406747 DOI: 10.1074/jbc.M109.011015  1
2009 Kiyota T, Yamamoto M, Schroder B, Jacobsen MT, Swan RJ, Lambert MP, Klein WL, Gendelman HE, Ransohoff RM, Ikezu T. AAV1/2-mediated CNS gene delivery of dominant-negative CCL2 mutant suppresses gliosis, beta-amyloidosis, and learning impairment of APP/PS1 mice. Molecular Therapy : the Journal of the American Society of Gene Therapy. 17: 803-9. PMID 19277012 DOI: 10.1038/mt.2009.44  1
2009 Lambert MP, Velasco PT, Viola KL, Klein WL. Targeting generation of antibodies specific to conformational epitopes of amyloid beta-derived neurotoxins. Cns & Neurological Disorders Drug Targets. 8: 65-81. PMID 19275637 DOI: 10.2174/187152709787601876  1
2009 De Felice FG, Vieira MN, Bomfim TR, Decker H, Velasco PT, Lambert MP, Viola KL, Zhao WQ, Ferreira ST, Klein WL. Protection of synapses against Alzheimer's-linked toxins: insulin signaling prevents the pathogenic binding of Abeta oligomers. Proceedings of the National Academy of Sciences of the United States of America. 106: 1971-6. PMID 19188609 DOI: 10.1073/pnas.0809158106  1
2009 Nishitsuji K, Tomiyama T, Ishibashi K, Ito K, Teraoka R, Lambert MP, Klein WL, Mori H. The E693Delta mutation in amyloid precursor protein increases intracellular accumulation of amyloid beta oligomers and causes endoplasmic reticulum stress-induced apoptosis in cultured cells. The American Journal of Pathology. 174: 957-69. PMID 19164507 DOI: 10.2353/ajpath.2009.080480  1
2009 Wang XP, Zhang JH, Wang YJ, Feng Y, Zhang X, Sun XX, Li JL, Du XT, Lambert MP, Yang SG, Zhao M, Klein WL, Liu RT. Conformation-dependent single-chain variable fragment antibodies specifically recognize beta-amyloid oligomers. Febs Letters. 583: 579-84. PMID 19162022 DOI: 10.1016/j.febslet.2008.12.064  1
2009 Wu JS, Lambert MP, Velasco PT, Gutiontov S, Sharma S, Joshi HM, Shekhawat G, Klein WL, Dravid VP. Oligomeric and fibrillar amyloid-beta42 studied by cryo-TEM Microscopy and Microanalysis. 15: 944-945. DOI: 10.1017/S1431927609095762  1
2008 Hirata-Fukae C, Li HF, Hoe HS, Gray AJ, Minami SS, Hamada K, Niikura T, Hua F, Tsukagoshi-Nagai H, Horikoshi-Sakuraba Y, Mughal M, Rebeck GW, LaFerla FM, Mattson MP, Iwata N, ... ... Klein WL, et al. Females exhibit more extensive amyloid, but not tau, pathology in an Alzheimer transgenic model. Brain Research. 1216: 92-103. PMID 18486110 DOI: 10.1016/j.brainres.2008.03.079  1
2008 McKee AC, Carreras I, Hossain L, Ryu H, Klein WL, Oddo S, LaFerla FM, Jenkins BG, Kowall NW, Dedeoglu A. Ibuprofen reduces Abeta, hyperphosphorylated tau and memory deficits in Alzheimer mice. Brain Research. 1207: 225-36. PMID 18374906 DOI: 10.1016/j.brainres.2008.01.095  1
2008 Viola KL, Velasco PT, Klein WL. Why Alzheimer's is a disease of memory: the attack on synapses by A beta oligomers (ADDLs). The Journal of Nutrition, Health & Aging. 12: 51S-7S. PMID 18165846  1
2008 Durairajan SS, Yuan Q, Xie L, Chan WS, Kum WF, Koo I, Liu C, Song Y, Huang JD, Klein WL, Li M. Salvianolic acid B inhibits Abeta fibril formation and disaggregates preformed fibrils and protects against Abeta-induced cytotoxicty. Neurochemistry International. 52: 741-50. PMID 17964692 DOI: 10.1016/j.neuint.2007.09.006  1
2008 Zhao WQ, De Felice FG, Fernandez S, Chen H, Lambert MP, Quon MJ, Krafft GA, Klein WL. Amyloid beta oligomers induce impairment of neuronal insulin receptors. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 22: 246-60. PMID 17720802 DOI: 10.1096/fj.06-7703com  1
2008 De Felice FG, Wu D, Lambert MP, Fernandez SJ, Velasco PT, Lacor PN, Bigio EH, Jerecic J, Acton PJ, Shughrue PJ, Chen-Dodson E, Kinney GG, Klein WL. Alzheimer's disease-type neuronal tau hyperphosphorylation induced by A beta oligomers. Neurobiology of Aging. 29: 1334-47. PMID 17403556 DOI: 10.1016/j.neurobiolaging.2007.02.029  1
2007 De Felice FG, Wasilewska-Sampaio AP, Barbosa AC, Gomes FC, Klein WL, Ferreira ST. Cyclic AMP enhancers and Abeta oligomerization blockers as potential therapeutic agents in Alzheimer's disease. Current Alzheimer Research. 4: 263-71. PMID 17627483 DOI: 10.2174/156720507781077287  1
2007 De Felice FG, Velasco PT, Lambert MP, Viola K, Fernandez SJ, Ferreira ST, Klein WL. Abeta oligomers induce neuronal oxidative stress through an N-methyl-D-aspartate receptor-dependent mechanism that is blocked by the Alzheimer drug memantine. The Journal of Biological Chemistry. 282: 11590-601. PMID 17308309 DOI: 10.1074/jbc.M607483200  1
2007 Lacor PN, Buniel MC, Furlow PW, Clemente AS, Velasco PT, Wood M, Viola KL, Klein WL. Abeta oligomer-induced aberrations in synapse composition, shape, and density provide a molecular basis for loss of connectivity in Alzheimer's disease. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 27: 796-807. PMID 17251419 DOI: 10.1523/JNEUROSCI.3501-06.2007  1
2007 Lambert MP, Velasco PT, Chang L, Viola KL, Fernandez S, Lacor PN, Khuon D, Gong Y, Bigio EH, Shaw P, De Felice FG, Krafft GA, Klein WL. Monoclonal antibodies that target pathological assemblies of Abeta. Journal of Neurochemistry. 100: 23-35. PMID 17116235 DOI: 10.1111/j.1471-4159.2006.04157.x  1
2006 Klein WL. Synaptic targeting by A beta oligomers (ADDLS) as a basis for memory loss in early Alzheimer's disease. Alzheimer's & Dementia : the Journal of the Alzheimer's Association. 2: 43-55. PMID 19595855 DOI: 10.1016/j.jalz.2005.11.003  1
2006 Wu Y, Wu Z, Butko P, Christen Y, Lambert MP, Klein WL, Link CD, Luo Y. Amyloid-beta-induced pathological behaviors are suppressed by Ginkgo biloba extract EGb 761 and ginkgolides in transgenic Caenorhabditis elegans. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 26: 13102-13. PMID 17167099 DOI: 10.1523/JNEUROSCI.3448-06.2006  1
2006 Ohno M, Chang L, Tseng W, Oakley H, Citron M, Klein WL, Vassar R, Disterhoft JF. Temporal memory deficits in Alzheimer's mouse models: rescue by genetic deletion of BACE1. The European Journal of Neuroscience. 23: 251-60. PMID 16420434 DOI: 10.1111/j.1460-9568.2005.04551.x  1
2006 Boutaud O, Montine TJ, Chang L, Klein WL, Oates JA. PGH2-derived levuglandin adducts increase the neurotoxicity of amyloid beta1-42. Journal of Neurochemistry. 96: 917-23. PMID 16412101 DOI: 10.1111/j.1471-4159.2005.03586.x  1
2006 Oddo S, Caccamo A, Tran L, Lambert MP, Glabe CG, Klein WL, LaFerla FM. Temporal profile of amyloid-beta (Abeta) oligomerization in an in vivo model of Alzheimer disease. A link between Abeta and tau pathology. The Journal of Biological Chemistry. 281: 1599-604. PMID 16282321 DOI: 10.1074/jbc.M507892200  1
2005 Haes AJ, Chang L, Klein WL, Van Duyne RP. Detection of a biomarker for Alzheimer's disease from synthetic and clinical samples using a nanoscale optical biosensor. Journal of the American Chemical Society. 127: 2264-71. PMID 15713105 DOI: 10.1021/ja044087q  1
2005 Georganopoulou DG, Chang L, Nam JM, Thaxton CS, Mufson EJ, Klein WL, Mirkin CA. Nanoparticle-based detection in cerebral spinal fluid of a soluble pathogenic biomarker for Alzheimer's disease. Proceedings of the National Academy of Sciences of the United States of America. 102: 2273-6. PMID 15695586 DOI: 10.1073/pnas.0409336102  1
2004 Lacor PN, Buniel MC, Chang L, Fernandez SJ, Gong Y, Viola KL, Lambert MP, Velasco PT, Bigio EH, Finch CE, Krafft GA, Klein WL. Synaptic targeting by Alzheimer's-related amyloid beta oligomers. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 24: 10191-200. PMID 15537891 DOI: 10.1523/JNEUROSCI.3432-04.2004  1
2004 De Felice FG, Vieira MN, Saraiva LM, Figueroa-Villar JD, Garcia-Abreu J, Liu R, Chang L, Klein WL, Ferreira ST. Targeting the neurotoxic species in Alzheimer's disease: inhibitors of Abeta oligomerization. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 18: 1366-72. PMID 15333579 DOI: 10.1096/fj.04-1764com  1
2004 Wang Z, Chang L, Klein WL, Thatcher GR, Venton DL. Per-6-substituted-per-6-deoxy beta-cyclodextrins inhibit the formation of beta-amyloid peptide derived soluble oligomers. Journal of Medicinal Chemistry. 47: 3329-33. PMID 15189029 DOI: 10.1021/jm034224e  1
2004 Klein WL, Stine WB, Teplow DB. Small assemblies of unmodified amyloid beta-protein are the proximate neurotoxin in Alzheimer's disease. Neurobiology of Aging. 25: 569-80. PMID 15172732 DOI: 10.1016/j.neurobiolaging.2004.02.010  1
2004 Haes AJ, Hall WP, Chang L, Klein WL, Van Duyne RP. A localized surface plasmon resonance biosensor: First steps toward an assay for Alzheimer's disease Nano Letters. 4: 1029-1034. DOI: 10.1021/nl049670j  1
2003 Chromy BA, Nowak RJ, Lambert MP, Viola KL, Chang L, Velasco PT, Jones BW, Fernandez SJ, Lacor PN, Horowitz P, Finch CE, Krafft GA, Klein WL. Self-assembly of Abeta(1-42) into globular neurotoxins. Biochemistry. 42: 12749-60. PMID 14596589 DOI: 10.1021/bi030029q  1
2003 Chang L, Bakhos L, Wang Z, Venton DL, Klein WL. Femtomole immunodetection of synthetic and endogenous amyloid-beta oligomers and its application to Alzheimer's disease drug candidate screening. Journal of Molecular Neuroscience : Mn. 20: 305-13. PMID 14501013 DOI: 10.1385/JMN:20:3:305  1
2003 Gong Y, Chang L, Viola KL, Lacor PN, Lambert MP, Finch CE, Krafft GA, Klein WL. Alzheimer's disease-affected brain: presence of oligomeric A beta ligands (ADDLs) suggests a molecular basis for reversible memory loss. Proceedings of the National Academy of Sciences of the United States of America. 100: 10417-22. PMID 12925731 DOI: 10.1073/pnas.1834302100  1
2003 Kim HJ, Chae SC, Lee DK, Chromy B, Lee SC, Park YC, Klein WL, Krafft GA, Hong ST. Selective neuronal degeneration induced by soluble oligomeric amyloid beta protein. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 17: 118-20. PMID 12424218 DOI: 10.1096/fj.01-0987fje  1
2002 Yu J, Bakhos L, Chang L, Holterman MJ, Klein WL, Venton DL. Per-6-substituted beta-cyclodextrin libraries inhibit formation of beta-amyloid-peptide (A beta)-derived, soluble oligomers. Journal of Molecular Neuroscience : Mn. 19: 51-5. PMID 12212793 DOI: 10.1007/s12031-002-0010-x  1
2002 Klein WL. Abeta toxicity in Alzheimer's disease: globular oligomers (ADDLs) as new vaccine and drug targets. Neurochemistry International. 41: 345-52. PMID 12176077 DOI: 10.1016/S0197-0186(02)00050-5  1
2002 Klein WL. ADDLs & protofibrils--the missing links? Neurobiology of Aging. 23: 231-5. PMID 11804707 DOI: 10.1016/S0197-4580(01)00312-8  1
2002 Wang HW, Pasternak JF, Kuo H, Ristic H, Lambert MP, Chromy B, Viola KL, Klein WL, Stine WB, Krafft GA, Trommer BL. Soluble oligomers of beta amyloid (1-42) inhibit long-term potentiation but not long-term depression in rat dentate gyrus. Brain Research. 924: 133-40. PMID 11750898 DOI: 10.1016/S0006-8993(01)03058-X  1
2001 Lambert MP, Viola KL, Chromy BA, Chang L, Morgan TE, Yu J, Venton DL, Krafft GA, Finch CE, Klein WL. Vaccination with soluble Abeta oligomers generates toxicity-neutralizing antibodies. Journal of Neurochemistry. 79: 595-605. PMID 11701763 DOI: 10.1046/j.1471-4159.2001.00592.x  1
2001 Klein WL, Krafft GA, Finch CE. Targeting small Abeta oligomers: the solution to an Alzheimer's disease conundrum? Trends in Neurosciences. 24: 219-24. PMID 11250006 DOI: 10.1016/S0166-2236(00)01749-5  1
2000 Chromy BA, Lambert MP, Klein WL. Increased Protein Tyrosine Phosphorylation in Apoptotic Neural Cell Death Due to Microtubule Perturbations. Neurotoxicity Research. 2: 357-372. PMID 25242875 DOI: 10.1007/BF03033343  0.6
2000 Longo VD, Viola KL, Klein WL, Finch CE. Reversible inactivation of superoxide-sensitive aconitase in Abeta1-42-treated neuronal cell lines. Journal of Neurochemistry. 75: 1977-85. PMID 11032887 DOI: 10.1046/j.1471-4159.2000.0751977.x  1
1998 Lambert MP, Barlow AK, Chromy BA, Edwards C, Freed R, Liosatos M, Morgan TE, Rozovsky I, Trommer B, Viola KL, Wals P, Zhang C, Finch CE, Krafft GA, Klein WL. Diffusible, nonfibrillar ligands derived from Abeta1-42 are potent central nervous system neurotoxins. Proceedings of the National Academy of Sciences of the United States of America. 95: 6448-53. PMID 9600986 DOI: 10.1073/pnas.95.11.6448  1
1997 Berg MM, Krafft GA, Klein WL. Rapid impact of beta-amyloid on paxillin in a neural cell line. Journal of Neuroscience Research. 50: 979-89. PMID 9452012 DOI: 10.1002/(SICI)1097-4547(19971215)50:6<979::AID-JNR8>3.0.CO;2-A  1
1997 Brown ER, Barlow AK, Bodovitz S, Finch CE, Krafft GA, Klein WK. Binding of toxic aoligomers to neuronal cell surface proteins Faseb Journal. 11: A974.  1
1996 Stevens GR, Zhang C, Berg MM, Lambert MP, Barber K, Cantallops I, Routtenberg A, Klein WL. CNS neuronal focal adhesion kinase forms clusters that co-localize with vinculin. Journal of Neuroscience Research. 46: 445-55. PMID 8950704 DOI: 10.1002/(SICI)1097-4547(19961115)46:4<445::AID-JNR6>3.0.CO;2-G  1
1996 Zhang C, Qiu HE, Krafft GA, Klein WL. A beta peptide enhances focal adhesion kinase/Fyn association in a rat CNS nerve cell line. Neuroscience Letters. 211: 187-90. PMID 8817572 DOI: 10.1016/0304-3940(96)12761-0  1
1996 Barber K, Mala RR, Lambert MP, Qiu R, MacDonald RC, Klein WL. Delivery of membrane-impermeant fluorescent probes into living neural cell populations by lipotransfer. Neuroscience Letters. 207: 17-20. PMID 8710199 DOI: 10.1016/0304-3940(96)12497-6  1
1996 Zhang C, Qiu HE, Krafft GA, Klein WL. Protein kinase C and F-actin are essential for stimulation of neuronal FAK tyrosine phosphorylation by G-proteins and amyloid beta protein. Febs Letters. 386: 185-8. PMID 8647278 DOI: 10.1016/0014-5793(96)00435-8  1
1995 Lambert MP, Sabo S, Zhang C, Enam SA, Klein WL. Constitutive Alzheimer's-type tau epitopes in a neuritogenic rat CNS cell line. Neurobiology of Aging. 16: 583-9. PMID 8544909 DOI: 10.1016/0197-4580(95)00042-D  1
1995 Barber K, Enam SA, Bodovitz S, Falduto M, Frail D, Klein WL. Particulate forms of APP in the extracellular milieu of cultured cells. Experimental Neurology. 132: 42-53. PMID 7720825 DOI: 10.1016/0014-4886(95)90057-8  1
1994 Pope WB, Lambert MP, Leypold B, Seupaul R, Sletten L, Krafft G, Klein WL. Microtubule-associated protein tau is hyperphosphorylated during mitosis in the human neuroblastoma cell line SH-SY5Y. Experimental Neurology. 126: 185-94. PMID 7925819 DOI: 10.1006/exnr.1994.1057  1
1993 Pope W, Enam SA, Bawa N, Miller BE, Ghanbari HA, Klein WL. Phosphorylated tau epitope of Alzheimer's disease is coupled to axon development in the avian central nervous system. Experimental Neurology. 120: 106-13. PMID 7682967 DOI: 10.1006/exnr.1993.1044  1
1992 Tsui HC, Pope WB, Kim CS, Klein WL. Transient expression of adheron molecules during chick retinal development. Journal of Neurobiology. 23: 720-38. PMID 1431842 DOI: 10.1002/neu.480230610  1
1979 Klein WL, Nathanson N, Nirenberg M. Muscarinic acetylcholine receptor regulation by accelerated rate of receptor loss. Biochemical and Biophysical Research Communications. 90: 506-12. PMID 508317 DOI: 10.1016/0006-291X(79)91264-6  1
1978 Nathanson NM, Klein WL, Nirenberg M. Regulation of adenylate cyclase activity mediated by muscarinic acetylcholine receptors. Proceedings of the National Academy of Sciences of the United States of America. 75: 1788-91. PMID 205870  1
1978 Burgermeister W, Klein WL, Nirenberg M, Witkop B. Comparative binding studies with cholinergic ligands and histrionicotoxin at muscarinic receptors of neural cell lines. Molecular Pharmacology. 14: 751-67. PMID 30889  1
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