William Klein, PhD - Publications

Affiliations: 
Neurobiology and Physiology Northwestern University, Evanston, IL 

51 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2022 Bartley SC, Proctor MT, Xia H, Ho E, Kang DS, Schuster K, Bicca MA, Seckler HS, Viola KL, Patrie SM, Kelleher NL, De Mello FG, Klein WL. An Essential Role for Alzheimer's-Linked Amyloid Beta Oligomers in Neurodevelopment: Transient Expression of Multiple Proteoforms during Retina Histogenesis. International Journal of Molecular Sciences. 23. PMID 35216328 DOI: 10.3390/ijms23042208  0.626
2020 Welikovitch LA, Do Carmo S, Maglóczky Z, Malcolm JC, Lőke J, Klein WL, Freund T, Cuello AC. Early intraneuronal amyloid triggers neuron-derived inflammatory signaling in APP transgenic rats and human brain. Proceedings of the National Academy of Sciences of the United States of America. PMID 32144141 DOI: 10.1073/pnas.1914593117  0.307
2019 Sellés MC, Fortuna J, Cercato M, Bitencourt A, Souza A, Prado V, Prado M, Sebollela A, Arancio O, Klein W, De Felice F, Jerusalinsky D, Ferreira S. Neuronal expression of NUsc1, a single-chain variable fragment antibody against Ab oligomers, protects synapses and rescues memory in Alzheimer's disease models Ibro Reports. 6: S497. DOI: 10.1016/J.Ibror.2019.07.1558  0.333
2018 Cline EN, Das A, Bicca MA, Mohammad SN, Schachner LF, Kamel JM, DiNunno N, Weng A, Paschall JD, Lo Bu R, Khan FM, Rollins MG, Ives AN, Shekhawat G, Nunes-Tavares N, ... Klein WL, et al. A Novel Crosslinking Protocol Stabilizes Amyloid β Oligomers Capable of Inducing Alzheimer's-Associated Pathologies. Journal of Neurochemistry. PMID 30565253 DOI: 10.1111/Jnc.14647  0.603
2017 DiChiara T, DiNunno N, Clark J, Bu RL, Cline EN, Rollins MG, Gong Y, Brody DL, Sligar SG, Velasco PT, Viola KL, Klein WL. Alzheimer's Toxic Amyloid Beta Oligomers: Unwelcome Visitors to the Na/K ATPase alpha3 Docking Station. The Yale Journal of Biology and Medicine. 90: 45-61. PMID 28356893  0.313
2016 Lauritzen I, Pardossi-Piquard R, Bourgeois A, Pagnotta S, Biferi MG, Barkats M, Lacor P, Klein W, Bauer C, Checler F. Intraneuronal aggregation of the β-CTF fragment of APP (C99) induces Aβ-independent lysosomal-autophagic pathology. Acta Neuropathologica. PMID 27138984 DOI: 10.1007/S00401-016-1577-6  0.349
2015 Viola KL, Klein WL. Amyloid β oligomers in Alzheimer's disease pathogenesis, treatment, and diagnosis. Acta Neuropathologica. 129: 183-206. PMID 25604547 DOI: 10.1007/s00401-015-1386-3  0.324
2014 Lourenco MV, Clarke J, Frozza RL, Forny-Germano L, Klein W, Holscher C, Munoz D, Ferreira ST, Felice FD. An Inflammatory Pathway Toward Synapse And Cognitive Impairment Triggered By Amyloid-Beta Oligomers: Novel Molecular Links Between Alzheimer'S Disease And Diabetes Alzheimers & Dementia. 10: 217. DOI: 10.1016/J.Jalz.2014.04.293  0.332
2013 Kam TI, Song S, Gwon Y, Park H, Yan JJ, Im I, Choi JW, Choi TY, Kim J, Song DK, Takai T, Kim YC, Kim KS, Choi SY, Choi S, Klein WL, et al. FcγRIIb mediates amyloid-β neurotoxicity and memory impairment in Alzheimer's disease. The Journal of Clinical Investigation. 123: 2791-802. PMID 23921129 DOI: 10.1172/Jci66827  0.315
2013 Ferreira S, Figueiredo C, Clarke J, Ribeiro F, Mota-Sales A, Ledo J, Costa C, Melo H, Saraiva L, Klein W, Sebollela A, Felice FD. Differential impact of high and low molecular mass beta-amyloid oligomers on synapse density, receptor composition and memory in mice Alzheimers & Dementia. 9: 520. DOI: 10.1016/J.Jalz.2013.04.244  0.323
2012 Nunes-Tavares N, Santos LE, Stutz B, Brito-Moreira J, Klein WL, Ferreira ST, de Mello FG. Inhibition of choline acetyltransferase as a mechanism for cholinergic dysfunction induced by amyloid-β peptide oligomers. The Journal of Biological Chemistry. 287: 19377-85. PMID 22505713 DOI: 10.1074/Jbc.M111.321448  0.605
2012 Forny-Germano L, de Menezes Lyra e Silva N, Brito-Moreira J, Batista AF, Martins S, Klein W, Houzel J, Ferreira S, Munoz D, De Felice F. P1-277: A nonhuman primate model of Alzheimer's disease with tangles and synapse loss triggered by Aß oligomers Alzheimer's & Dementia. 8: P203-P203. DOI: 10.1016/J.Jalz.2012.05.557  0.32
2011 Panchal M, Lacor P, Klein W, Duyckaerts C. Histological localization of amyloid-β oligomers in the human brain during the course of Alzheimer's disease Alzheimers & Dementia. 7. DOI: 10.1016/J.Jalz.2011.05.1137  0.334
2011 Bao F, Lacor P, Klein W, Marutle A, Nordberg A. P2-213: Different distribution of soluble beta-amyloid assemblies in the Tg2576 mouse brain and Alzheimer disease autopsy brain Alzheimer's & Dementia. 7: S380-S381. DOI: 10.1016/J.Jalz.2011.05.1096  0.337
2010 Tomiyama T, Matsuyama S, Iso H, Umeda T, Takuma H, Ohnishi K, Ishibashi K, Teraoka R, Sakama N, Yamashita T, Nishitsuji K, Ito K, Shimada H, Lambert MP, Klein WL, et al. A mouse model of amyloid beta oligomers: their contribution to synaptic alteration, abnormal tau phosphorylation, glial activation, and neuronal loss in vivo. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 30: 4845-56. PMID 20371804 DOI: 10.1523/JNEUROSCI.5825-09.2010  0.318
2010 Leon WC, Canneva F, Partridge V, Allard S, Ferretti MT, DeWilde A, Vercauteren F, Atifeh R, Ducatenzeiler A, Klein W, Szyf M, Alhonen L, Cuello AC. A novel transgenic rat model with a full Alzheimer's-like amyloid pathology displays pre-plaque intracellular amyloid-beta-associated cognitive impairment. Journal of Alzheimer's Disease : Jad. 20: 113-26. PMID 20164597 DOI: 10.3233/Jad-2010-1349  0.396
2010 Lacor PN, Wadhwani AR, Sureka R, Giljohann D, Pitt J, Xu J, Contractor A, Triller A, Mirkin C, Klein W. P1-114: Synaptotoxicity of Abeta oligomers results from “hijacking” of metabotropic glutamate receptors Alzheimer's & Dementia. 6: S207-S207. DOI: 10.1016/J.Jalz.2010.05.663  0.334
2009 Pitt J, Roth W, Lacor P, Smith AB, Blankenship M, Velasco P, De Felice F, Breslin P, Klein WL. Alzheimer's-associated Abeta oligomers show altered structure, immunoreactivity and synaptotoxicity with low doses of oleocanthal. Toxicology and Applied Pharmacology. 240: 189-97. PMID 19631677 DOI: 10.1016/J.Taap.2009.07.018  0.309
2009 Peng S, Garzon DJ, Marchese M, Klein W, Ginsberg SD, Francis BM, Mount HT, Mufson EJ, Salehi A, Fahnestock M. Decreased brain-derived neurotrophic factor depends on amyloid aggregation state in transgenic mouse models of Alzheimer's disease. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 29: 9321-9. PMID 19625522 DOI: 10.1523/Jneurosci.4736-08.2009  0.354
2009 Kiyota T, Yamamoto M, Xiong H, Lambert MP, Klein WL, Gendelman HE, Ransohoff RM, Ikezu T. CCL2 accelerates microglia-mediated Abeta oligomer formation and progression of neurocognitive dysfunction. Plos One. 4: e6197. PMID 19593388 DOI: 10.1371/Journal.Pone.0006197  0.301
2008 De Felice FG, Wu D, Lambert MP, Fernandez SJ, Velasco PT, Lacor PN, Bigio EH, Jerecic J, Acton PJ, Shughrue PJ, Chen-Dodson E, Kinney GG, Klein WL. Alzheimer's disease-type neuronal tau hyperphosphorylation induced by A beta oligomers. Neurobiology of Aging. 29: 1334-47. PMID 17403556 DOI: 10.1016/J.Neurobiolaging.2007.02.029  0.312
2008 Ferretti MT, Bruno M, Partridge V, Arvanitis D, Leon W, Ducatenzeiler A, Glabe C, Klein W, Cuello AC. P1-086: Intracellular accumulation of Aβ oligomers and inflammatory response precede plaque formation in a new transgenic model of the Alzheimer-like amyloid pathology Alzheimers & Dementia. 4. DOI: 10.1016/J.Jalz.2008.05.672  0.37
2007 De Felice FG, Wasilewska-Sampaio AP, Barbosa AC, Gomes FC, Klein WL, Ferreira ST. Cyclic AMP enhancers and Abeta oligomerization blockers as potential therapeutic agents in Alzheimer's disease. Current Alzheimer Research. 4: 263-71. PMID 17627483 DOI: 10.2174/156720507781077287  0.305
2007 Lambert MP, Velasco PT, Chang L, Viola KL, Fernandez S, Lacor PN, Khuon D, Gong Y, Bigio EH, Shaw P, De Felice FG, Krafft GA, Klein WL. Monoclonal antibodies that target pathological assemblies of Abeta. Journal of Neurochemistry. 100: 23-35. PMID 17116235 DOI: 10.1111/J.1471-4159.2006.04157.X  0.308
2006 Oddo S, Caccamo A, Tran L, Lambert MP, Glabe CG, Klein WL, LaFerla FM. Temporal profile of amyloid-beta (Abeta) oligomerization in an in vivo model of Alzheimer disease. A link between Abeta and tau pathology. The Journal of Biological Chemistry. 281: 1599-604. PMID 16282321 DOI: 10.1074/Jbc.M507892200  0.304
2004 Lacor PN, Buniel MC, Chang L, Fernandez SJ, Gong Y, Viola KL, Lambert MP, Velasco PT, Bigio EH, Finch CE, Krafft GA, Klein WL. Synaptic targeting by Alzheimer's-related amyloid beta oligomers. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 24: 10191-200. PMID 15537891 DOI: 10.1523/Jneurosci.3432-04.2004  0.331
2004 De Felice FG, Vieira MN, Saraiva LM, Figueroa-Villar JD, Garcia-Abreu J, Liu R, Chang L, Klein WL, Ferreira ST. Targeting the neurotoxic species in Alzheimer's disease: inhibitors of Abeta oligomerization. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 18: 1366-72. PMID 15333579 DOI: 10.1096/Fj.04-1764Com  0.306
2004 Klein WL, Stine WB, Teplow DB. Small assemblies of unmodified amyloid beta-protein are the proximate neurotoxin in Alzheimer's disease. Neurobiology of Aging. 25: 569-80. PMID 15172732 DOI: 10.1016/J.Neurobiolaging.2004.02.010  0.3
2003 Chromy BA, Nowak RJ, Lambert MP, Viola KL, Chang L, Velasco PT, Jones BW, Fernandez SJ, Lacor PN, Horowitz P, Finch CE, Krafft GA, Klein WL. Self-assembly of Abeta(1-42) into globular neurotoxins. Biochemistry. 42: 12749-60. PMID 14596589 DOI: 10.1021/Bi030029Q  0.658
2003 Chang L, Bakhos L, Wang Z, Venton DL, Klein WL. Femtomole immunodetection of synthetic and endogenous amyloid-beta oligomers and its application to Alzheimer's disease drug candidate screening. Journal of Molecular Neuroscience : Mn. 20: 305-13. PMID 14501013 DOI: 10.1385/Jmn:20:3:305  0.312
2003 Gong Y, Chang L, Viola KL, Lacor PN, Lambert MP, Finch CE, Krafft GA, Klein WL. Alzheimer's disease-affected brain: presence of oligomeric A beta ligands (ADDLs) suggests a molecular basis for reversible memory loss. Proceedings of the National Academy of Sciences of the United States of America. 100: 10417-22. PMID 12925731 DOI: 10.1073/Pnas.1834302100  0.3
2003 Kim HJ, Chae SC, Lee DK, Chromy B, Lee SC, Park YC, Klein WL, Krafft GA, Hong ST. Selective neuronal degeneration induced by soluble oligomeric amyloid beta protein. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 17: 118-20. PMID 12424218 DOI: 10.1096/Fj.01-0987Fje  0.676
2002 Klein WL. Abeta toxicity in Alzheimer's disease: globular oligomers (ADDLs) as new vaccine and drug targets. Neurochemistry International. 41: 345-52. PMID 12176077 DOI: 10.1016/S0197-0186(02)00050-5  0.307
2002 Wang HW, Pasternak JF, Kuo H, Ristic H, Lambert MP, Chromy B, Viola KL, Klein WL, Stine WB, Krafft GA, Trommer BL. Soluble oligomers of beta amyloid (1-42) inhibit long-term potentiation but not long-term depression in rat dentate gyrus. Brain Research. 924: 133-40. PMID 11750898 DOI: 10.1016/S0006-8993(01)03058-X  0.656
2001 Lambert MP, Viola KL, Chromy BA, Chang L, Morgan TE, Yu J, Venton DL, Krafft GA, Finch CE, Klein WL. Vaccination with soluble Abeta oligomers generates toxicity-neutralizing antibodies. Journal of Neurochemistry. 79: 595-605. PMID 11701763 DOI: 10.1046/J.1471-4159.2001.00592.X  0.671
2001 Klein WL, Krafft GA, Finch CE. Targeting small Abeta oligomers: the solution to an Alzheimer's disease conundrum? Trends in Neurosciences. 24: 219-24. PMID 11250006 DOI: 10.1016/S0166-2236(00)01749-5  0.311
2000 Chromy BA, Lambert MP, Klein WL. Increased Protein Tyrosine Phosphorylation in Apoptotic Neural Cell Death Due to Microtubule Perturbations. Neurotoxicity Research. 2: 357-372. PMID 25242875 DOI: 10.1007/Bf03033343  0.622
1998 Lambert MP, Barlow AK, Chromy BA, Edwards C, Freed R, Liosatos M, Morgan TE, Rozovsky I, Trommer B, Viola KL, Wals P, Zhang C, Finch CE, Krafft GA, Klein WL. Diffusible, nonfibrillar ligands derived from Abeta1-42 are potent central nervous system neurotoxins. Proceedings of the National Academy of Sciences of the United States of America. 95: 6448-53. PMID 9600986 DOI: 10.1073/Pnas.95.11.6448  0.679
1995 Lambert MP, Sabo S, Zhang C, Enam SA, Klein WL. Constitutive Alzheimer's-type tau epitopes in a neuritogenic rat CNS cell line. Neurobiology of Aging. 16: 583-9. PMID 8544909 DOI: 10.1016/0197-4580(95)00042-D  0.615
1995 Barber K, Enam SA, Bodovitz S, Falduto M, Frail D, Klein WL. Particulate forms of APP in the extracellular milieu of cultured cells. Experimental Neurology. 132: 42-53. PMID 7720825 DOI: 10.1016/0014-4886(95)90057-8  0.593
1994 Pope WB, Lambert MP, Leypold B, Seupaul R, Sletten L, Krafft G, Klein WL. Microtubule-associated protein tau is hyperphosphorylated during mitosis in the human neuroblastoma cell line SH-SY5Y. Experimental Neurology. 126: 185-94. PMID 7925819 DOI: 10.1006/Exnr.1994.1057  0.505
1993 Pope W, Enam SA, Bawa N, Miller BE, Ghanbari HA, Klein WL. Phosphorylated tau epitope of Alzheimer's disease is coupled to axon development in the avian central nervous system. Experimental Neurology. 120: 106-13. PMID 7682967 DOI: 10.1006/Exnr.1993.1044  0.656
1992 Tsui HC, Pope WB, Kim CS, Klein WL. Transient expression of adheron molecules during chick retinal development. Journal of Neurobiology. 23: 720-38. PMID 1431842 DOI: 10.1002/neu.480230610  0.491
1988 de Mello MC, Klein WL, de Mello FG. L-glutamate evoked release of GABA from cultured avian retina cells does not require glutamate receptor activation. Brain Research. 443: 166-72. PMID 2896053 DOI: 10.1016/0006-8993(88)91609-5  0.529
1987 Lankford K, De Mello FG, Klein WL. A transient embryonic dopamine receptor inhibits growth cone motility and neurite outgrowth in a subset of avian retina neurons. Neuroscience Letters. 75: 169-74. PMID 2952906 DOI: 10.1016/0304-3940(87)90292-8  0.558
1985 Large TH, Rauh JJ, De Mello FG, Klein WL. Two molecular weight forms of muscarinic acetylcholine receptors in the avian central nervous system: switch in predominant form during differentiation of synapses. Proceedings of the National Academy of Sciences of the United States of America. 82: 8785-9. PMID 3866251 DOI: 10.1073/PNAS.82.24.8785  0.572
1984 Ventura AL, Klein WL, de Mello FG. Differential ontogenesis of D1 and D2 dopaminergic receptors in the chick embryo retina. Brain Research. 314: 217-23. PMID 6200189 DOI: 10.1016/0165-3806(84)90044-0  0.555
1982 de Mello MC, Ventura AL, Paes de Carvalho R, Klein WL, de Mello FG. Regulation of dopamine- and adenosine-dependent adenylate cyclase systems of chicken embryo retina cells in culture. Proceedings of the National Academy of Sciences of the United States of America. 79: 5708-12. PMID 6291061 DOI: 10.1073/pnas.79.18.5708  0.572
1979 Klein WL, Nathanson N, Nirenberg M. Muscarinic acetylcholine receptor regulation by accelerated rate of receptor loss. Biochemical and Biophysical Research Communications. 90: 506-12. PMID 508317 DOI: 10.1016/0006-291X(79)91264-6  0.601
1978 Nathanson NM, Klein WL, Nirenberg M. Regulation of adenylate cyclase activity mediated by muscarinic acetylcholine receptors. Proceedings of the National Academy of Sciences of the United States of America. 75: 1788-91. PMID 205870  0.589
1978 Burgermeister W, Klein WL, Nirenberg M, Witkop B. Comparative binding studies with cholinergic ligands and histrionicotoxin at muscarinic receptors of neural cell lines. Molecular Pharmacology. 14: 751-67. PMID 30889  0.474
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