Jochen Schacht, Ph.D. - Publications

Affiliations: 
Kresge Hearing Research Institute University of Michigan, Ann Arbor, Ann Arbor, MI 
Area:
Inner Ear Biochemistry
Website:
http://www.khri.med.umich.edu/research/schacht_lab/

132 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2015 Yang CH, Schrepfer T, Schacht J. Age-related hearing impairment and the triad of acquired hearing loss. Frontiers in Cellular Neuroscience. 9: 276. PMID 26283913 DOI: 10.3389/fncel.2015.00276  1
2015 Shalev M, Rozenberg H, Smolkin B, Nasereddin A, Kopelyanskiy D, Belakhov V, Schrepfer T, Schacht J, Jaffe CL, Adir N, Baasov T. Structural basis for selective targeting of leishmanial ribosomes: aminoglycoside derivatives as promising therapeutics. Nucleic Acids Research. 43: 8601-13. PMID 26264664 DOI: 10.1093/nar/gkv821  1
2015 Oishi N, Duscha S, Boukari H, Meyer M, Xie J, Wei G, Schrepfer T, Roschitzki B, Boettger EC, Schacht J. XBP1 mitigates aminoglycoside-induced endoplasmic reticulum stress and neuronal cell death. Cell Death & Disease. 6: e1763. PMID 25973683 DOI: 10.1038/cddis.2015.108  1
2015 Altschuler RA, Dolan DF, Halsey K, Kanicki A, Deng N, Martin C, Eberle J, Kohrman DC, Miller RA, Schacht J. Age-related changes in auditory nerve-inner hair cell connections, hair cell numbers, auditory brain stem response and gap detection in UM-HET4 mice. Neuroscience. 292: 22-33. PMID 25665752 DOI: 10.1016/j.neuroscience.2015.01.068  1
2014 Kendall A, Schacht J. Disparities in auditory physiology and pathology between C57BL/6J and C57BL/6N substrains. Hearing Research. 318: 18-22. PMID 25456090 DOI: 10.1016/j.heares.2014.10.005  1
2014 Duscha S, Boukari H, Shcherbakov D, Salian S, Silva S, Kendall A, Kato T, Akbergenov R, Perez-Fernandez D, Bernet B, Vaddi S, Thommes P, Schacht J, Crich D, Vasella A, et al. Identification and evaluation of improved 4'-O-(alkyl) 4,5-disubstituted 2-deoxystreptamines as next-generation aminoglycoside antibiotics. Mbio. 5: e01827-14. PMID 25271289 DOI: 10.1128/mBio.01827-14  1
2014 Oishi N, Kendall A, Schacht J. Metformin protects against gentamicin-induced hair cell death in vitro but not ototoxicity in vivo. Neuroscience Letters. 583: 65-9. PMID 25240593 DOI: 10.1016/j.neulet.2014.09.028  1
2014 Shulman E, Belakhov V, Wei G, Kendall A, Meyron-Holtz EG, Ben-Shachar D, Schacht J, Baasov T. Designer aminoglycosides that selectively inhibit cytoplasmic rather than mitochondrial ribosomes show decreased ototoxicity: a strategy for the treatment of genetic diseases. The Journal of Biological Chemistry. 289: 2318-30. PMID 24302717 DOI: 10.1074/jbc.M113.533588  1
2014 Xue X, Mutyam V, Tang L, Biswas S, Du M, Jackson LA, Dai Y, Belakhov V, Shalev M, Chen F, Schacht J, J Bridges R, Baasov T, Hong J, Bedwell DM, et al. Synthetic aminoglycosides efficiently suppress cystic fibrosis transmembrane conductance regulator nonsense mutations and are enhanced by ivacaftor. American Journal of Respiratory Cell and Molecular Biology. 50: 805-16. PMID 24251786 DOI: 10.1165/rcmb.2013-0282OC  1
2013 Oishi N, Chen J, Zheng HW, Hill K, Schacht J, Sha SH. Tumor necrosis factor-alpha-mutant mice exhibit high frequency hearing loss. Journal of the Association For Research in Otolaryngology : Jaro. 14: 801-11. PMID 23996384 DOI: 10.1007/s10162-013-0410-3  1
2013 Chen FQ, Zheng HW, Schacht J, Sha SH. Mitochondrial peroxiredoxin 3 regulates sensory cell survival in the cochlea. Plos One. 8: e61999. PMID 23626763 DOI: 10.1371/journal.pone.0061999  1
2013 Böttger EC, Schacht J. The mitochondrion: a perpetrator of acquired hearing loss. Hearing Research. 303: 12-9. PMID 23361190 DOI: 10.1016/j.heares.2013.01.006  1
2013 Altschuler RA, Raphael Y, Sha SH, Schacht J, Martin DC, Miller JM. Protection and Repair of Hearing Principles of Tissue Engineering: Fourth Edition. 1375-1395. DOI: 10.1016/B978-0-12-398358-9.00065-3  1
2012 Oishi N, Talaska AE, Schacht J. Ototoxicity in dogs and cats. The Veterinary Clinics of North America. Small Animal Practice. 42: 1259-71. PMID 23122180 DOI: 10.1016/j.cvsm.2012.08.005  1
2012 Schacht J, Talaska AE, Rybak LP. Cisplatin and aminoglycoside antibiotics: hearing loss and its prevention. Anatomical Record (Hoboken, N.J. : 2007). 295: 1837-50. PMID 23045231 DOI: 10.1002/ar.22578  1
2012 Matt T, Ng CL, Lang K, Sha SH, Akbergenov R, Shcherbakov D, Meyer M, Duscha S, Xie J, Dubbaka SR, Perez-Fernandez D, Vasella A, Ramakrishnan V, Schacht J, Böttger EC. Dissociation of antibacterial activity and aminoglycoside ototoxicity in the 4-monosubstituted 2-deoxystreptamine apramycin. Proceedings of the National Academy of Sciences of the United States of America. 109: 10984-9. PMID 22699498 DOI: 10.1073/pnas.1204073109  1
2012 Schacht J, Altschuler R, Burke DT, Chen S, Dolan D, Galecki AT, Kohrman D, Miller RA. Alleles that modulate late life hearing in genetically heterogeneous mice. Neurobiology of Aging. 33: 1842.e15-29. PMID 22305187 DOI: 10.1016/j.neurobiolaging.2011.12.034  1
2012 Chen FQ, Hill K, Guan YJ, Schacht J, Sha SH. Activation of apoptotic pathways in the absence of cell death in an inner-ear immortomouse cell line. Hearing Research. 284: 33-41. PMID 22240458 DOI: 10.1016/j.heares.2011.12.007  1
2012 Sha SH, Kanicki A, Halsey K, Wearne KA, Schacht J. Antioxidant-enriched diet does not delay the progression of age-related hearing loss. Neurobiology of Aging. 33: 1010.e15-6. PMID 22154190 DOI: 10.1016/j.neurobiolaging.2011.10.023  1
2011 Canlon B, Schacht J. Introduction: Pathology of the inner ear. Hearing Research. 281: 1-2. PMID 22051189 DOI: 10.1016/j.heares.2011.10.005  1
2011 Op de Beeck K, Schacht J, Van Camp G. Apoptosis in acquired and genetic hearing impairment: the programmed death of the hair cell. Hearing Research. 281: 18-27. PMID 21782914 DOI: 10.1016/j.heares.2011.07.002  1
2011 Xie J, Talaska AE, Schacht J. New developments in aminoglycoside therapy and ototoxicity. Hearing Research. 281: 28-37. PMID 21640178 DOI: 10.1016/j.heares.2011.05.008  1
2011 Miller RA, Dolan D, Han M, Kohler W, Schacht J. Resistance of skin fibroblasts to peroxide and UV damage predicts hearing loss in aging mice. Aging Cell. 10: 362-3. PMID 21395967 DOI: 10.1111/j.1474-9726.2010.00668.x  1
2011 Oishi N, Schacht J. Emerging treatments for noise-induced hearing loss. Expert Opinion On Emerging Drugs. 16: 235-45. PMID 21247358 DOI: 10.1517/14728214.2011.552427  1
2010 Sha SH, Chen FQ, Schacht J. PTEN attenuates PIP3/Akt signaling in the cochlea of the aging CBA/J mouse. Hearing Research. 264: 86-92. PMID 19761823 DOI: 10.1016/j.heares.2009.09.002  1
2009 Sha SH, Chen FQ, Schacht J. Activation of cell death pathways in the inner ear of the aging CBA/J mouse. Hearing Research. 254: 92-9. PMID 19422898 DOI: 10.1016/j.heares.2009.04.019  1
2009 Nudelman I, Rebibo-Sabbah A, Cherniavsky M, Belakhov V, Hainrichson M, Chen F, Schacht J, Pilch DS, Ben-Yosef T, Baasov T. Development of novel aminoglycoside (NB54) with reduced toxicity and enhanced suppression of disease-causing premature stop mutations. Journal of Medicinal Chemistry. 52: 2836-45. PMID 19309154 DOI: 10.1021/jm801640k  1
2009 Chen FQ, Schacht J, Sha SH. Aminoglycoside-induced histone deacetylation and hair cell death in the mouse cochlea. Journal of Neurochemistry. 108: 1226-36. PMID 19141081 DOI: 10.1111/j.1471-4159.2009.05871.x  1
2008 Sha SH, Kanicki A, Dootz G, Talaska AE, Halsey K, Dolan D, Altschuler R, Schacht J. Age-related auditory pathology in the CBA/J mouse. Hearing Research. 243: 87-94. PMID 18573325 DOI: 10.1016/j.heares.2008.06.001  1
2008 Samson J, Wiktorek-Smagur A, Politanski P, Rajkowska E, Pawlaczyk-Luszczynska M, Dudarewicz A, Sha SH, Schacht J, Sliwinska-Kowalska M. Noise-induced time-dependent changes in oxidative stress in the mouse cochlea and attenuation by D-methionine. Neuroscience. 152: 146-50. PMID 18234425 DOI: 10.1016/j.neuroscience.2007.11.015  1
2008 Kong WJ, Hao J, Schacht J. The history of otology in traditional Chinese medicine Sketches of Otohistory. 65-70. DOI: 10.1159/000119424  1
2008 Schacht J, Hawkins JE. Ototoxicity: Drug-Induced hearing loss Sketches of Otohistory. 59-64. DOI: 10.1159/000119423  1
2008 Hawkins JE, Schacht J. Noise-Induced Hearing Loss Sketches of Otohistory. 54-58. DOI: 10.1159/000119422  1
2008 Schacht J, Hawkins JE. Presby[a]cusis Sketches of Otohistory. 49-53. DOI: 10.1159/000119421  1
2008 Hawkins JE, Schacht J. The emergence of vestibular science Sketches of Otohistory. 43-48. DOI: 10.1159/000119420  1
2008 Hawkins JE, Schacht J. The Nineteenth-Century rise of laryngology Sketches of Otohistory. 39-42. DOI: 10.1159/000119419  1
2008 Schacht J, Hawkins JE. A cell by any other name: Cochlear eponyms Sketches of Otohistory. 19-29. DOI: 10.1159/000119410  1
2007 Kharkheli E, Kevanishvili Z, Maglakelidze T, Davitashvili O, Schacht J. Does vitamin E prevent gentamicin-induced ototoxicity? Georgian Medical News. 14-7. PMID 17595452  1
2007 Sharashenidze N, Schacht J, Kevanishvili Z. Age-related hearing loss: gender differences. Georgian Medical News. 14-8. PMID 17473326  1
2007 Minami SB, Yamashita D, Ogawa K, Schacht J, Miller JM. Creatine and tempol attenuate noise-induced hearing loss. Brain Research. 1148: 83-9. PMID 17359945 DOI: 10.1016/j.brainres.2007.02.021  1
2007 Jiang H, Talaska AE, Schacht J, Sha SH. Oxidative imbalance in the aging inner ear. Neurobiology of Aging. 28: 1605-12. PMID 16920227 DOI: 10.1016/j.neurobiolaging.2006.06.025  1
2007 Chen Y, Huang WG, Zha DJ, Qiu JH, Wang JL, Sha SH, Schacht J. Aspirin attenuates gentamicin ototoxicity: from the laboratory to the clinic. Hearing Research. 226: 178-82. PMID 16844331 DOI: 10.1016/j.heares.2006.05.008  1
2007 Talaska AE, Schacht J. Mechanisms of noise damage to the cochlea Audiological Medicine. 5: 3-9. DOI: 10.1080/16513860601158887  1
2007 Altschuler RA, Raphael Y, Martin DC, Schacht J, Anderson DJ, Miller JM. Protection and repair of audition Principles of Tissue Engineering. 995-1008. DOI: 10.1016/B978-012370615-7/50070-6  1
2007 Talaska AE, Schacht J. Adverse Effects of Aminoglycoside Therapy Aminoglycoside Antibiotics: From Chemical Biology to Drug Discovery. 255-266. DOI: 10.1002/9780470149676.ch9  1
2006 Jiang H, Sha SH, Schacht J. Kanamycin alters cytoplasmic and nuclear phosphoinositide signaling in the organ of Corti in vivo. Journal of Neurochemistry. 99: 269-76. PMID 16903869 DOI: 10.1111/j.1471-4159.2006.04117.x  1
2006 Sha SH, Qiu JH, Schacht J. Aspirin to prevent gentamicin-induced hearing loss. The New England Journal of Medicine. 354: 1856-7. PMID 16641409 DOI: 10.1056/NEJMc053428  1
2006 Jiang H, Sha SH, Schacht J. Rac/Rho pathway regulates actin depolymerization induced by aminoglycoside antibiotics. Journal of Neuroscience Research. 83: 1544-51. PMID 16521128 DOI: 10.1002/jnr.20833  1
2006 Vicente-Torres MA, Schacht J. A BAD link to mitochondrial cell death in the cochlea of mice with noise-induced hearing loss. Journal of Neuroscience Research. 83: 1564-72. PMID 16521126 DOI: 10.1002/jnr.20832  1
2006 Kong WJ, Hao J, Schacht J. Sketches of otohistory Part 12: The history of otology in traditional Chinese medicine. Audiology & Neuro-Otology. 11: 145-50. PMID 16514235 DOI: 10.1159/000091411  1
2006 Schacht J, Hawkins JE. Sketches of otohistory. Part 11: Ototoxicity: drug-induced hearing loss. Audiology & Neuro-Otology. 11: 1-6. PMID 16219991 DOI: 10.1159/000088850  1
2006 Jiang H, Sha SH, Forge A, Schacht J. Caspase-independent pathways of hair cell death induced by kanamycin in vivo. Cell Death and Differentiation. 13: 20-30. PMID 16021180 DOI: 10.1038/sj.cdd.4401706  1
2006 Talaska AE, Schacht J, Fischel-Ghodsian N. Molecular and genetic aspects of aminoglycoside-induced hearing loss Drug Discovery Today: Disease Mechanisms. 3: 119-124. DOI: 10.1016/j.ddmec.2006.03.010  1
2005 Hawkins JE, Schacht J. Sketches of otohistory. Part 10: noise-induced hearing loss. Audiology & Neuro-Otology. 10: 305-9. PMID 16103641 DOI: 10.1159/000087347  1
2005 Schacht J, Hawkins JE. Sketches of otohistory. Part 9: presby[a]cusis. Audiology & Neuro-Otology. 10: 243-7. PMID 15976497 DOI: 10.1159/000086524  1
2005 Yamashita D, Jiang HY, Le Prell CG, Schacht J, Miller JM. Post-exposure treatment attenuates noise-induced hearing loss. Neuroscience. 134: 633-42. PMID 15961244 DOI: 10.1016/j.neuroscience.2005.04.015  1
2005 Hawkins JE, Schacht J. Sketches of otohistory. Part 8: The emergence of vestibular science. Audiology & Neuro-Otology. 10: 185-90. PMID 15832015 DOI: 10.1159/000085076  1
2005 Hawkins JE, Schacht J. Sketches of otohistory. Part 7: The nineteenth-century rise of laryngology. Audiology & Neuro-Otology. 10: 130-3. PMID 15724083 DOI: 10.1159/000084022  1
2005 Lesniak W, Pecoraro VL, Schacht J. Ternary complexes of gentamicin with iron and lipid catalyze formation of reactive oxygen species. Chemical Research in Toxicology. 18: 357-64. PMID 15720143 DOI: 10.1021/tx0496946  1
2005 Jiang H, Sha SH, Schacht J. NF-kappaB pathway protects cochlear hair cells from aminoglycoside-induced ototoxicity. Journal of Neuroscience Research. 79: 644-51. PMID 15672440 DOI: 10.1002/jnr.20392  1
2005 Hawkins JE. Sketches of otohistory. Part 6: Gustaf Retzius. Audiology & Neuro-Otology. 10: 65-8. PMID 15650297 DOI: 10.1159/000083361  1
2005 Endo T, Nakagawa T, Iguchi F, Kita T, Okano T, Sha SH, Schacht J, Shiga A, Kim TS, Ito J. Elevation of superoxide dismutase increases acoustic trauma from noise exposure. Free Radical Biology & Medicine. 38: 492-8. PMID 15649651 DOI: 10.1016/j.freeradbiomed.2004.11.008  1
2005 Hawkins JE. Sketches of otohistory: part 5: Prosper Ménière: physician, botanist, classicist, diarist and historian. Audiology & Neuro-Otology. 10: 1-5. PMID 15627721 DOI: 10.1159/000082305  1
2005 Talaska AE, Schacht J. Prevention of aminoglycoside ototoxicity: From the laboratory to the clinic Volta Review. 105: 371-382.  1
2004 Yamashita D, Miller JM, Jiang HY, Minami SB, Schacht J. AIF and EndoG in noise-induced hearing loss. Neuroreport. 15: 2719-22. PMID 15597041  1
2004 Minami SB, Sha SH, Schacht J. Antioxidant protection in a new animal model of cisplatin-induced ototoxicity. Hearing Research. 198: 137-43. PMID 15567610 DOI: 10.1016/j.heares.2004.07.016  1
2004 Schacht J, Hawkins JE. Sketches of otohistory part 4: a cell by any other name: cochlear eponyms. Audiology & Neuro-Otology. 9: 317-27. PMID 15467285 DOI: 10.1159/000081311  1
2004 Minami SB, Yamashita D, Schacht J, Miller JM. Calcineurin activation contributes to noise-induced hearing loss. Journal of Neuroscience Research. 78: 383-92. PMID 15389832 DOI: 10.1002/jnr.20267  1
2004 Yamashita D, Jiang HY, Schacht J, Miller JM. Delayed production of free radicals following noise exposure. Brain Research. 1019: 201-9. PMID 15306254 DOI: 10.1016/j.brainres.2004.05.104  1
2004 Lautermann J, Dehne N, Schacht J, Jahnke K. [Aminoglycoside- and cisplatin-ototoxicity: from basic science to clinics]. Laryngo- Rhino- Otologie. 83: 317-23. PMID 15143449 DOI: 10.1055/s-2004-814280  1
2004 Kawamoto K, Sha SH, Minoda R, Izumikawa M, Kuriyama H, Schacht J, Raphael Y. Antioxidant gene therapy can protect hearing and hair cells from ototoxicity. Molecular Therapy : the Journal of the American Society of Gene Therapy. 9: 173-81. PMID 14759801 DOI: 10.1016/j.ymthe.2003.11.020  1
2004 Matsunobu T, Ogita K, Schacht J. Modulation of activator protein 1/DNA binding activity by acoustic overstimulation in the guinea-pig cochlea. Neuroscience. 123: 1037-43. PMID 14751294 DOI: 10.1016/j.neuroscience.2003.10.022  1
2004 Schacht J, Hoke M. Editorial: Audiology and Neuro-Otology Audiology and Neuro-Otology. 9: 65. DOI: 10.1159/000075996  1
2003 Lesniak W, Mc Laren J, Harris WR, Pecoraro VL, Schacht J. An isocratic separation of underivatized gentamicin components, 1H NMR assignment and protonation pattern. Carbohydrate Research. 338: 2853-62. PMID 14667706 DOI: 10.1016/j.carres.2003.08.005  1
2003 Le Prell CG, Dolan DF, Schacht J, Miller JM, Lomax MI, Altschuler RA. Pathways for protection from noise induced hearing loss. Noise & Health. 5: 1-17. PMID 14558888  1
2003 Miller JM, Brown JN, Schacht J. 8-iso-prostaglandin F(2alpha), a product of noise exposure, reduces inner ear blood flow. Audiology & Neuro-Otology. 8: 207-21. PMID 12811002 DOI: 10.1159/000071061  1
2003 Wang AM, Sha SH, Lesniak W, Schacht J. Tanshinone (Salviae miltiorrhizae extract) preparations attenuate aminoglycoside-induced free radical formation in vitro and ototoxicity in vivo. Antimicrobial Agents and Chemotherapy. 47: 1836-41. PMID 12760856 DOI: 10.1128/AAC.47.6.1836-1841.2003  1
2003 Lautermann J, Schacht J, Jahnke K. [Aminoglycoside toxicity. Pathomechanisms, clinical management and means of prevention]. Hno. 51: 344-51; quiz 352. PMID 12682739 DOI: 10.1007/s00106-003-0830-1  1
2003 Ohinata Y, Miller JM, Schacht J. Protection from noise-induced lipid peroxidation and hair cell loss in the cochlea. Brain Research. 966: 265-73. PMID 12618349 DOI: 10.1016/S0006-8993(02)04205-1  1
2003 Lesniak W, Harris WR, Kravitz JY, Schacht J, Pecoraro VL. Solution chemistry of copper(II)-gentamicin complexes: relevance to metal-related aminoglycoside toxicity. Inorganic Chemistry. 42: 1420-9. PMID 12611506 DOI: 10.1021/ic025965t  1
2002 Wu WJ, Sha SH, Schacht J. Recent advances in understanding aminoglycoside ototoxicity and its prevention. Audiology & Neuro-Otology. 7: 171-4. PMID 12053140 DOI: 10.1159/000058305  1
2002 Li G, Sha SH, Zotova E, Arezzo J, Van de Water T, Schacht J. Salicylate protects hearing and kidney function from cisplatin toxicity without compromising its oncolytic action. Laboratory Investigation; a Journal of Technical Methods and Pathology. 82: 585-96. PMID 12003999 DOI: 10.1038/labinvest.3780453  1
2001 Chung JW, Schacht J. ATP and nitric oxide modulate intracellular calcium in isolated pillar cells of the guinea pig cochlea. Journal of the Association For Research in Otolaryngology : Jaro. 2: 399-407. PMID 11833612 DOI: 10.1007/s101620010058  1
2001 Wu WJ, Sha SH, McLaren JD, Kawamoto K, Raphael Y, Schacht J. Aminoglycoside ototoxicity in adult CBA, C57BL and BALB mice and the Sprague-Dawley rat. Hearing Research. 158: 165-78. PMID 11506949 DOI: 10.1016/S0378-5955(01)00303-3  1
2001 Sha SH, Zajic G, Epstein CJ, Schacht J. Overexpression of copper/zinc-superoxide dismutase protects from kanamycin-induced hearing loss. Audiology & Neuro-Otology. 6: 117-23. PMID 11474137 DOI: 10.1159/000046818  1
2001 Sha SH, Taylor R, Forge A, Schacht J. Differential vulnerability of basal and apical hair cells is based on intrinsic susceptibility to free radicals. Hearing Research. 155: 1-8. PMID 11335071 DOI: 10.1016/S0378-5955(01)00224-6  1
2001 Matsunobu T, Chung JW, Schacht J. Acetylcholine-evoked calcium increases in Deiters' cells of the guinea pig cochlea suggest alpha9-like receptors. Journal of Neuroscience Research. 63: 252-6. PMID 11170174 DOI: 10.1002/1097-4547(20010201)63:3<252::AID-JNR1018>3.0.CO;2-0  1
2000 Sinswat P, Wu WJ, Sha SH, Schacht J. Protection from ototoxicity of intraperitoneal gentamicin in guinea pig. Kidney International. 58: 2525-32. PMID 11115087 DOI: 10.1046/j.1523-1755.2000.00437.x  1
2000 Ohinata Y, Miller JM, Altschuler RA, Schacht J. Intense noise induces formation of vasoactive lipid peroxidation products in the cochlea. Brain Research. 878: 163-73. PMID 10996147 DOI: 10.1016/S0006-8993(00)02733-5  1
2000 Gilmartin MR, McLaren J, Schacht J. Confounding factors in lanthanide ion probe spectrofluorometric assay of aminoglycoside antibiotics. Analytical Biochemistry. 283: 116-9. PMID 10929818 DOI: 10.1006/abio.2000.4626  1
2000 Ohinata Y, Yamasoba T, Schacht J, Miller JM. Glutathione limits noise-induced hearing loss. Hearing Research. 146: 28-34. PMID 10913881 DOI: 10.1016/S0378-5955(00)00096-4  1
2000 Matsunobu T, Schacht J. Nitric oxide/cyclic GMP pathway attenuates ATP-evoked intracellular calcium increase in supporting cells of the guinea pig cochlea. The Journal of Comparative Neurology. 423: 452-61. PMID 10870085 DOI: 10.1002/1096-9861(20000731)423:3<452::AID-CNE8>3.0.CO;2-Y  1
2000 Ogita K, Matsunobu T, Schacht J. Acoustic trauma enhances DNA binding of transcription factor AP-1 in the guinea pig inner ear. Neuroreport. 11: 859-62. PMID 10757534  1
2000 Sha SH, Schacht J. Antioxidants attenuate gentamicin-induced free radical formation in vitro and ototoxicity in vivo: D-methionine is a potential protectant. Hearing Research. 142: 34-40. PMID 10748326 DOI: 10.1016/S0378-5955(00)00003-4  1
2000 Forge A, Schacht J. Aminoglycoside antibiotics. Audiology & Neuro-Otology. 5: 3-22. PMID 10686428  1
1999 Tian F, Fessenden JD, Schacht J. Cyclic GMP-dependent protein kinase-I in the guinea pig cochlea. Hearing Research. 131: 63-70. PMID 10355605  0.56
1999 Fessenden JD, Altschuler RA, Seasholtz AF, Schacht J. Nitric oxide/cyclic guanosine monophosphate pathway in the peripheral and central auditory system of the rat. The Journal of Comparative Neurology. 404: 52-63. PMID 9886024 DOI: 10.1002/(SICI)1096-9861(19990201)404:1<52::AID-CNE4>3.0.CO;2-W  1
1998 Fessenden JD, Schacht J. The nitric oxide/cyclic GMP pathway: a potential major regulator of cochlear physiology. Hearing Research. 118: 168-76. PMID 9606072  0.56
1997 Ryals B, Westbrook E, Schacht J. Morphological evidence of ototoxicity of the iron chelator deferoxamine. Hearing Research. 112: 44-8. PMID 9367228 DOI: 10.1016/S0378-5955(97)00094-4  1
1997 Fessenden JD, Schacht J. Localization of soluble guanylate cyclase activity in the guinea pig cochlea suggests involvement in regulation of blood flow and supporting cell physiology. The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society. 45: 1401-8. PMID 9313801  0.56
1997 Hawkins JE, Schacht J. Smith et al.:"The electrolytes of the labyrinthine fluids." (Laryngoscope 1954;64:141-153). The Laryngoscope. 107: 293-7. PMID 9121300  1
1995 Lautermann J, McLaren J, Schacht J. Glutathione protection against gentamicin ototoxicity depends on nutritional status. Hearing Research. 86: 15-24. PMID 8567412 DOI: 10.1016/0378-5955(95)00049-A  1
1995 Coling DE, Schacht J. Second messengers in the cochlea. Acta Oto-Laryngologica. 115: 218-21. PMID 7610808 DOI: 10.3109/00016489509139295  1
1994 Ogawa K, McLaren J, Schacht J. Effect of aging on myo-inositol and phosphoinositide metabolism in the cochlear and vestibular sensory epithelia of the rat. Hearing Research. 73: 155-62. PMID 8188544 DOI: 10.1016/0378-5955(94)90230-5  1
1994 Garetz SL, Rhee DJ, Schacht J. Sulfhydryl compounds and antioxidants inhibit cytotoxicity to outer hair cells of a gentamicin metabolite in vitro. Hearing Research. 77: 75-80. PMID 7928739 DOI: 10.1016/0378-5955(94)90254-2  1
1994 Fessenden JD, Coling DE, Schacht J. Detection and characterization of nitric oxide synthase in the mammalian cochlea. Brain Research. 668: 9-15. PMID 7535658 DOI: 10.1016/0006-8993(94)90505-3  1
1994 Coling DE, Naik RM, Schacht J. Calcium and calmodulin inhibit phosphorylation of a novel auditory nerve protein. Hearing Research. 72: 197-205. PMID 7512086 DOI: 10.1016/0378-5955(94)90219-4  1
1993 Forge A, Zajic G, Li L, Nevill G, Schacht J. Structural variability of the sub-surface cisternae in intact, isolated outer hair cells shown by fluorescent labelling of intracellular membranes and freeze-fracture. Hearing Research. 64: 175-83. PMID 8432688 DOI: 10.1016/0378-5955(93)90003-J  1
1993 Schwartz DR, Schacht J, Miller JM, Frey K, Altschuler RA. Chronic electrical stimulation reverses deafness-related depression of electrically evoked 2-deoxyglucose activity in the guinea pig inferior colliculus. Hearing Research. 70: 243-9. PMID 8294268 DOI: 10.1016/0378-5955(93)90162-T  1
1993 Zajic G, Forge A, Schacht J. Membrane stains as an objective means to distinguish isolated inner and outer hair cells. Hearing Research. 66: 53-7. PMID 7682544 DOI: 10.1016/0378-5955(93)90259-4  1
1991 Zajic G, Nair TS, Ptok M, Van Waes C, Altschuler RA, Schacht J, Carey TE. Monoclonal antibodies to inner ear antigens: I. Antigens expressed by supporting cells of the guinea pig cochlea. Hearing Research. 52: 59-71. PMID 2061214 DOI: 10.1016/0378-5955(91)90187-E  1
1991 Ptok M, Nair TS, Altschuler RA, Schacht J, Carey TE. Monoclonal antibodies to inner ear antigens: II. Antigens expressed in sensory cell stereocilia. Hearing Research. 57: 79-90. PMID 1774215 DOI: 10.1016/0378-5955(91)90077-M  1
1991 Pujol R, Zajic G, Dulon D, Raphael Y, Altschuler RA, Schacht J. First appearance and development of motile properties in outer hair cells isolated from guinea-pig cochlea. Hearing Research. 57: 129-41. PMID 1774204 DOI: 10.1016/0378-5955(91)90082-K  1
1991 Coling DE, Schacht J. Protein phosphorylation in the organ of Corti: differential regulation by second messengers between base and apex. Hearing Research. 57: 113-20. PMID 1774202 DOI: 10.1016/0378-5955(91)90080-S  1
1990 Bobbin RP, Fallon M, Puel JL, Bryant G, Bledsoe SC, Zajic G, Schacht J. Acetylcholine, carbachol, and GABA induce no detectable change in the length of isolated outer hair cells. Hearing Research. 47: 39-52. PMID 2228797 DOI: 10.1016/0378-5955(90)90165-L  1
1989 Riaz M, Weiner ND, Schacht J. Separation of liposome populations differing in phosphoinositide content by chromatography on immobilized neomycin. Journal of Pharmaceutical Sciences. 78: 172-5. PMID 2541241  1
1989 Forge A, Zajic G, Davies S, Weiner N, Schacht J. Gentamicin alters membrane structure as shown by freeze-fracture of liposomes. Hearing Research. 37: 129-39. PMID 2536649 DOI: 10.1016/0378-5955(89)90035-X  1
1988 Henley CM, Mahran LG, Schacht J. Inhibition of renal ornithine decarboxylase by aminoglycoside antibiotics in vitro. Biochemical Pharmacology. 37: 1679-82. PMID 3377830 DOI: 10.1016/0006-2952(88)90427-3  1
1988 Henley CM, Schacht J. Pharmacokinetics of aminoglycoside antibiotics in blood, inner-ear fluids and tissues and their relationship to ototoxicity. Audiology : Official Organ of the International Society of Audiology. 27: 137-46. PMID 3044302 DOI: 10.3109/00206098809081584  1
1987 Williams SE, Smith DE, Schacht J. Characteristics of gentamicin uptake in the isolated crista ampullaris of the inner ear of the guinea pig. Biochemical Pharmacology. 36: 89-95. PMID 3801057 DOI: 10.1016/0006-2952(87)90385-6  1
1987 Williams SE, Zenner HP, Schacht J. Three molecular steps of aminoglycoside ototoxicity demonstrated in outer hair cells. Hearing Research. 30: 11-8. PMID 3680049 DOI: 10.1016/0378-5955(87)90177-8  1
1987 Henley CM, Gerhardt HJ, Schacht J. Inhibition of inner ear ornithine decarboxylase by neomycin in-vitro. Brain Research Bulletin. 19: 695-8. PMID 3125950 DOI: 10.1016/0361-9230(87)90056-6  1
1986 Williams SE, Schacht J. Binding of neomycin and calcium to phospholipids and other anionic compounds. The Journal of Antibiotics. 39: 457-62. PMID 3700247  1
1977 Stockhorst E, Schacht J. Radioactive labeling of phospholipids and proteins by cochlear perfusion in the guinea pig and the effect of neomycin. Acta Oto-Laryngologica. 83: 401-9. PMID 888675  0.01
1976 Springer AD, Schacht J, Agranoff BW. The effect of memory blocking antibiotics and their analogs on acetylcholinesterase. Pharmacology, Biochemistry, and Behavior. 5: 1-3. PMID 996038 DOI: 10.1016/0091-3057(76)90278-1  1
1975 Preston RE, Johnsson LG, Hill JH, Schacht J. Incorporation of radioactive calcium into otolithic membranes and middle ear ossicles of the gerbil. Acta Oto-Laryngologica. 80: 269-75. PMID 1180040 DOI: 10.3109/00016487509121327  1
1974 Schacht J, Neale EA, Agranoff BW. Cholinergic stimulation of phospholipid labelling from (32P) orthophosphate in guinea-pig cortex synaptosomes in vitro: subsynaptosomal localization. Journal of Neurochemistry. 23: 211-8. PMID 4368498  1
1974 Schacht J, Agranoff BW. Detergent-like action of tetraphenylborate on phospholipid labelling in guinea pig cortex subfractions. Journal of Neurochemistry. 22: 473-8. PMID 4364346  1
1974 Schacht J, Agranoff BW. Stimulation of hydrolysis of phosphatidic acid by cholinergic agents in guinea pig synaptosomes. The Journal of Biological Chemistry. 249: 1551-7. PMID 4361741  1
1973 Schacht J, Agranoff BW. Acetylcholine stimulates hydrolysis of 32 P-labeled phosphatidic acid in guinea pig synaptosomes. Biochemical and Biophysical Research Communications. 50: 934-41. PMID 4347533 DOI: 10.1016/0006-291X(73)91335-1  1
1972 Schacht J, Agranoff BW. Phospholipid labelling by ( 32 P)-orthophosphate and ( 3 H)-myo-inositol in the stimulated goldfish brain in vivo. Journal of Neurochemistry. 19: 1417-21. PMID 4337116  1
1972 Schacht J, Agranoff BW. Effects of acetylcholine on labeling of phosphatidate and phosphoinositides by ( 32 P) orthophosphate in nerve ending fractions of guinea pig cortex. The Journal of Biological Chemistry. 247: 771-7. PMID 4333513  1
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