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Peter Brazda, Ph.D. - Related publications

2019- Princess Máxima Center for Pediatric Oncology 
molecular biology, cancer biology, single cell transcriptomics, single molecule biophysics
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50 most relevant papers in past 60 days:
Year Citation  Score
2021 Boritzki V, Hübner H, Allikalt A, Gmeiner P, Wöhrl BM. Optimizing the Expression of Human Dopamine Receptors in . International Journal of Molecular Sciences. 22. PMID 34445358 DOI: 10.3390/ijms22168647   
2021 Cremers GAO, Rosier BJHM, Meijs A, Tito NB, van Duijnhoven SMJ, van Eenennaam H, Albertazzi L, de Greef TFA. Determinants of Ligand-Functionalized DNA Nanostructure-Cell Interactions. Journal of the American Chemical Society. 143: 10131-10142. PMID 34180666 DOI: 10.1021/jacs.1c02298   
2021 Schaber EN, Ivanova N, Iliev S, Petrova J, Gocheva G, Madjarova G, Ivanova A. Initial Stages of Spontaneous Binding of Folate-Based Vectors to Folate Receptor-α Observed by Unbiased Molecular Dynamics. The Journal of Physical Chemistry. B. 125: 7598-7612. PMID 34247488 DOI: 10.1021/acs.jpcb.1c00488   
2021 Schaber EN, Ivanova N, Iliev S, Petrova J, Gocheva G, Madjarova G, Ivanova A. Initial Stages of Spontaneous Binding of Folate-Based Vectors to Folate Receptor-α Observed by Unbiased Molecular Dynamics. The Journal of Physical Chemistry. B. 125: 7598-7612. PMID 34247488 DOI: 10.1021/acs.jpcb.1c00488   
2021 Meng Q, Fu Y, Li S, Yan Y, Duan D, Anthony DD, Zhu Y, Wu X, Qian F, Wu C. Rapid, sensitive and cost-effective determination of immune checkpoint inhibitor activity using a magnetic bead-based binding assay. Journal of Immunological Methods. 113134. PMID 34464606 DOI: 10.1016/j.jim.2021.113134   
2021 Nobrega JN, Raymond R, Rajji TK, Pollock BG. A calcium fluorescence assay for quantification of cholinergic receptor activity of clinical drugs in serum - comparison with radioactive methods. Journal of Pharmacological and Toxicological Methods. 107118. PMID 34481920 DOI: 10.1016/j.vascn.2021.107118   
2021 Spiegelberg D, Stenberg J, Richalet P, Vanhove M. K determination from time-resolved experiments on live cells with LigandTracer and reconciliation with end-point flow cytometry measurements. European Biophysics Journal : Ebj. PMID 34302187 DOI: 10.1007/s00249-021-01560-2   
2021 Yang W, Nan H, Xu Z, Huang Z, Chen S, Li J, Li J, Yang H. DNA-Templated Glycan Labeling for Monitoring Receptor Spatial Distribution in Living Cells. Analytical Chemistry. PMID 34474560 DOI: 10.1021/acs.analchem.1c01815   
2021 Giubilaro J, Schuetz DA, Stepniewski TM, Namkung Y, Khoury E, Lara-Márquez M, Campbell S, Beautrait A, Armando S, Radresa O, Duchaine J, Lamarche-Vane N, Claing A, Selent J, Bouvier M, et al. Discovery of a dual Ras and ARF6 inhibitor from a GPCR endocytosis screen. Nature Communications. 12: 4688. PMID 34344896 DOI: 10.1038/s41467-021-24968-y   
2021 Eguchi A, Ueki A, Hoshiyama J, Kuwata K, Chikaoka Y, Kawamura T, Nagatoishi S, Tsumoto K, Ueki R, Sando S. A DNA Aptamer That Inhibits the Aberrant Signaling of Fibroblast Growth Factor Receptor in Cancer Cells. Jacs Au. 1: 578-585. PMID 34467321 DOI: 10.1021/jacsau.0c00121   
2021 Dodat F, Mader S, Lévesque D. Minireview: what is known about SUMOylation among NR4A family members? Journal of Molecular Biology. 167212. PMID 34437889 DOI: 10.1016/j.jmb.2021.167212   
2021 Wang X, Sandberg ML, Martin AD, Negri KR, Gabrelow GB, Nampe DP, Wu ML, McElvain ME, Toledo Warshaviak D, Lee WH, Oh J, Daris ME, Chai F, Yao C, Furney J, et al. Potent, Selective CARs as Potential T-Cell Therapeutics for HPV-positive Cancers. Journal of Immunotherapy (Hagerstown, Md. : 1997). PMID 34432728 DOI: 10.1097/CJI.0000000000000386   
2021 Zhang J, Tang W, Bhatia NK, Xu Y, Paudyal N, Liu D, Kim S, Song R, XiangWei W, Shaulsky G, Myers SJ, Dobyns W, Jayaraman V, Traynelis SF, Yuan H, et al. A Variant Associated With Myoclonus and Developmental Delay: From Molecular Mechanism to Rescue Pharmacology. Frontiers in Genetics. 12: 694312. PMID 34413877 DOI: 10.3389/fgene.2021.694312   
2021 van Aalst E, Wylie BJ. Cholesterol Is a Dose-Dependent Positive Allosteric Modulator of CCR3 Ligand Affinity and G Protein Coupling. Frontiers in Molecular Biosciences. 8: 724603. PMID 34490352 DOI: 10.3389/fmolb.2021.724603   
2021 Cong X, Maurel D, Déméné H, Vasiliauskaité-Brooks I, Hagelberger J, Peysson F, Saint-Paul J, Golebiowski J, Granier S, Sounier R. Molecular insights into the biased signaling mechanism of the μ-opioid receptor. Molecular Cell. PMID 34433090 DOI: 10.1016/j.molcel.2021.07.033   
2021 Lu S, He X, Yang Z, Chai Z, Zhou S, Wang J, Rehman AU, Ni D, Pu J, Sun J, Zhang J. Activation pathway of a G protein-coupled receptor uncovers conformational intermediates as targets for allosteric drug design. Nature Communications. 12: 4721. PMID 34354057 DOI: 10.1038/s41467-021-25020-9   
2021 Okimoto R, Ino K, Ishizu K, Takamatsu H, Sakamoto K, Yuyama H, Fuji H, Someya A, Ohtake A, Ishigami T, Masuda N, Takeda M, Kajioka S, Yoshimura N. . The Journal of Pharmacology and Experimental Therapeutics. PMID 34244231 DOI: 10.1124/jpet.121.000709   
2021 Smith C, Li A, Krishnamurthy N, Lemmon MA. Phosphatidylserine binding directly regulates TIM-3 function. The Biochemical Journal. PMID 34435619 DOI: 10.1042/BCJ20210425   
2021 Gonias SL. Plasminogen activator receptor assemblies in cell-signaling, innate immunity, and inflammation. American Journal of Physiology. Cell Physiology. PMID 34406905 DOI: 10.1152/ajpcell.00269.2021   
2021 Manoliu LCE, Martin EC, Milac AL, Spiridon L. Effective Use of Empirical Data for Virtual Screening against APJR GPCR Receptor. Molecules (Basel, Switzerland). 26. PMID 34443478 DOI: 10.3390/molecules26164894   
2021 Ren X, Gelinas AD, Linehan M, Iwasaki A, Wang W, Janjic N, Marie Pyle A. Title: Evolving a RIG-I antagonist: a modified DNA aptamer mimics viral RNA. Journal of Molecular Biology. 167227. PMID 34487794 DOI: 10.1016/j.jmb.2021.167227   
2021 Kilpatrick LE, Hill SJ. The use of fluorescence correlation spectroscopy to characterise the molecular mobility of G protein-coupled receptors in membrane microdomains: an update. Biochemical Society Transactions. 49: 1547-1554. PMID 34436556 DOI: 10.1042/BST20201001   
2021 Deganutti G, Atanasio S, Rujan RM, Sexton PM, Wootten D, Reynolds CA. Exploring Ligand Binding to Calcitonin Gene-Related Peptide Receptors. Frontiers in Molecular Biosciences. 8: 720561. PMID 34513925 DOI: 10.3389/fmolb.2021.720561   
2021 Morimoto S, Morishima N, Watanabe D, Kato Y, Shibata N, Ichihara A. Immunohistochemistry for (Pro)renin Receptor in Humans. International Journal of Endocrinology. 2021: 8828610. PMID 34367278 DOI: 10.1155/2021/8828610   
2021 Reinmuth L, Hsiao CC, Hamann J, Rosenkilde M, Mackrill J. Multiple Targets for Oxysterols in Their Regulation of the Immune System. Cells. 10. PMID 34440846 DOI: 10.3390/cells10082078   
2021 Budzinski J, Maschauer S, Kobayashi H, Couvineau P, Vogt H, Gmeiner P, Roggenhofer A, Prante O, Bouvier M, Weikert D. Bivalent ligands promote endosomal trafficking of the dopamine D3 receptor-neurotensin receptor 1 heterodimer. Communications Biology. 4: 1062. PMID 34508168 DOI: 10.1038/s42003-021-02574-4   
2021 Rosier N, Grätz L, Schihada H, Möller J, Işbilir A, Humphrys LJ, Nagl M, Seibel U, Lohse MJ, Pockes S. A Versatile Sub-Nanomolar Fluorescent Ligand Enables NanoBRET Binding Studies and Single-Molecule Microscopy at the Histamine H Receptor. Journal of Medicinal Chemistry. PMID 34309390 DOI: 10.1021/acs.jmedchem.1c01089   
2021 Gonzalez CU, Carrillo E, Berka V, Jayaraman V. Structural Arrangement Produced by Concanavalin A Binding to Homomeric GluK2 Receptors. Membranes. 11. PMID 34436376 DOI: 10.3390/membranes11080613   
2021 Lenglez S, Sablon A, Fénelon G, Boland A, Deleuze JF, Boutoleau-Bretonnière C, Nicolas G, Demoulin JB. Distinct functional classes of PDGFRB pathogenic variants in primary familial brain calcification. Human Molecular Genetics. PMID 34494111 DOI: 10.1093/hmg/ddab258   
2021 Palaka BK, Vijayakumar S, Choudhury SR. Exploring nod factor receptors activation process in chickpea by bridging modelling, docking and molecular dynamics simulations. International Journal of Biological Macromolecules. PMID 34450153 DOI: 10.1016/j.ijbiomac.2021.08.152   
2021 Light TP, Brun D, Guardado-Calvo P, Pederzoli R, Haouz A, Neipel F, Rey FA, Hristova K, Backovic M. Human herpesvirus 8 molecular mimicry of ephrin ligands facilitates cell entry and triggers EphA2 signaling. Plos Biology. 19: e3001392. PMID 34499637 DOI: 10.1371/journal.pbio.3001392   
2021 Kumar R, Grinberg AV, Li H, Kuo TH, Sako D, Krishnan L, Liharska K, Li J, Grenha R, Maguire MC, Briscoe SD, Pearsall RS, Herrin BR, Suragani RNVS, Castonguay R. Functionally diverse heteromeric traps for ligands of the transforming growth factor-β superfamily. Scientific Reports. 11: 18341. PMID 34526551 DOI: 10.1038/s41598-021-97203-9   
2021 Wu N, Olechwier AM, Brunner C, Edwards PC, Tsai CJ, Tate CG, Schertler GFX, Schneider G, Deupi X, Zenobi R, Ma P. High-mass MALDI-MS unravels ligand-mediated G protein-coupling selectivity to GPCRs. Proceedings of the National Academy of Sciences of the United States of America. 118. PMID 34326250 DOI: 10.1073/pnas.2024146118   
2021 Yuan Y, Jia G, Wu C, Wang W, Cheng L, Li Q, Li Z, Luo K, Yang S, Yan W, Su Z, Shao Z. Structures of signaling complexes of lipid receptors S1PR1 and S1PR5 reveal mechanisms of activation and drug recognition. Cell Research. PMID 34526663 DOI: 10.1038/s41422-021-00566-x   
2021 Haubrich J, Font J, Quast RB, Goupil-Lamy A, Scholler P, Nevoltris D, Acher F, Chames P, Rondard P, Prézeau L, Pin JP. A nanobody activating metabotropic glutamate receptor 4 discriminates between homo- and heterodimers. Proceedings of the National Academy of Sciences of the United States of America. 118. PMID 34385321 DOI: 10.1073/pnas.2105848118   
2021 Vassiliou AG, Athanasiou N, Vassiliadi DA, Jahaj E, Keskinidou C, Kotanidou A, Dimopoulou I. Glucocorticoid and mineralocorticoid receptor expression in critical illness: A narrative review. World Journal of Critical Care Medicine. 10: 102-111. PMID 34316445 DOI: 10.5492/wjccm.v10.i4.102   
2021 Piha-Paul SA, Geva R, Tan TJ, Lim DW, Hierro C, Doi T, Rahma O, Lesokhin A, Luke JJ, Otero J, Nardi L, Singh A, Xyrafas A, Chen X, Mataraza J, et al. First-in-human phase I/Ib open-label dose-escalation study of GWN323 (anti-GITR) as a single agent and in combination with spartalizumab (anti-PD-1) in patients with advanced solid tumors and lymphomas. Journal For Immunotherapy of Cancer. 9. PMID 34389618 DOI: 10.1136/jitc-2021-002863   
2021 Haider S, Pandey P, Reddy CR, Lambert JA, Chittiboyina AG. Novel Machaeriol Analogues as Modulators of Cannabinoid Receptors: Structure-Activity Relationships of (+)-Hexahydrocannabinoids and Their Isoform Selectivities. Acs Omega. 6: 20408-20421. PMID 34395989 DOI: 10.1021/acsomega.1c02413   
2021 Chen Z, Oh D, Biswas KH, Zaidel-Bar R, Groves JT. Probing the effect of clustering on EphA2 receptor signaling efficiency by subcellular control of ligand-receptor mobility. Elife. 10. PMID 34414885 DOI: 10.7554/eLife.67379   
2021 Fernandez RA, Quimque MT, Notarte KI, Manzano JA, Pilapil DY, de Leon VN, San Jose JJ, Villalobos O, Muralidharan NH, Gromiha MM, Brogi S, Macabeo APG. Myxobacterial depsipeptide chondramides interrupt SARS-CoV-2 entry by targeting its broad, cell tropic spike protein. Journal of Biomolecular Structure & Dynamics. 1-12. PMID 34463219 DOI: 10.1080/07391102.2021.1969281   
2021 Binder P, Schnellbächer ND, Höfer T, Becker NB, Schwarz US. Optimal ligand discrimination by asymmetric dimerization and turnover of interferon receptors. Proceedings of the National Academy of Sciences of the United States of America. 118. PMID 34507994 DOI: 10.1073/pnas.2103939118   
2021 Ma S, Chen Y, Dai A, Yin W, Guo J, Yang D, Zhou F, Jiang Y, Wang MW, Xu HE. Structural mechanism of calcium-mediated hormone recognition and Gβ interaction by the human melanocortin-1 receptor. Cell Research. PMID 34453129 DOI: 10.1038/s41422-021-00557-y   
2021 Vaidya AS, Peterson FC, Eckhardt J, Xing Z, Park SY, Dejonghe W, Takeuchi J, Pri-Tal O, Faria J, Elzinga D, Volkman BF, Todoroki Y, Mosquna A, Okamoto M, Cutler SR. Click-to-lead design of a picomolar ABA receptor antagonist with potent activity in vivo. Proceedings of the National Academy of Sciences of the United States of America. 118. PMID 34531324 DOI: 10.1073/pnas.2108281118   
2021 Basit A, Karim AM, Asif M, Ali T, Lee JH, Jeon JH, Rehman SU, Lee SH. Designing Short Peptides to Block the Interaction of SARS-CoV-2 and Human ACE2 for COVID-19 Therapeutics. Frontiers in Pharmacology. 12: 731828. PMID 34512357 DOI: 10.3389/fphar.2021.731828   
2021 Siclari JJ, Gardner KH. Two steps, one ligand: How PPARγ binds small-molecule agonists. Structure (London, England : 1993). 29: 935-936. PMID 34478635 DOI: 10.1016/j.str.2021.08.005   
2021 Patel A, Bhatt M, Soni A, Sharma P. Identification of steroidal saponins from Tribulus terrestris and their in silico docking studies. Journal of Cellular Biochemistry. PMID 34337761 DOI: 10.1002/jcb.30113   
2021 Pruitt RN, Locci F, Wanke F, Zhang L, Saile SC, Joe A, Karelina D, Hua C, Fröhlich K, Wan WL, Hu M, Rao S, Stolze SC, Harzen A, Gust AA, et al. The EDS1-PAD4-ADR1 node mediates Arabidopsis pattern-triggered immunity. Nature. PMID 34497423 DOI: 10.1038/s41586-021-03829-0   
2021 Hur J, Kang ES, Hwang JS, Lee WJ, Won JP, Lee HG, Kim E, Seo HG. Peroxisome proliferator-activated receptor-δ-mediated upregulation of catalase helps to reduce ultraviolet B-induced cellular injury in dermal fibroblasts. Journal of Dermatological Science. PMID 34420848 DOI: 10.1016/j.jdermsci.2021.08.003   
2021 Cevheroğlu O, Murat M, Mingu-Akmete S, Son ÇD. Ste2p Under the Microscope: the Investigation of Oligomeric States of a Yeast G Protein-Coupled Receptor. The Journal of Physical Chemistry. B. 125: 9526-9536. PMID 34433281 DOI: 10.1021/acs.jpcb.1c05872   
2021 Tao XX, Wang B, Zuo SK, Yu Y. [Identification of mouse lines with HA-tagged prostaglandin receptors]. Sheng Li Xue Bao : [Acta Physiologica Sinica]. 73: 559-570. PMID 34405212