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De-Maw Chuang, PhD - Publications

National Institute of Mental Health, Bethesda, MD, United States 

135 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2016 Leng Y, Wang J, Wang Z, Liao HM, Wei M, Leeds P, Chuang DM. Valproic Acid and Other HDAC Inhibitors Upregulate FGF21 Gene Expression and Promote Process Elongation in Glia by Inhibiting HDAC2 and 3. The International Journal of Neuropsychopharmacology / Official Scientific Journal of the Collegium Internationale Neuropsychopharmacologicum (Cinp). PMID 27207921 DOI: 10.1093/ijnp/pyw035  0.52
2016 Linares GR, Chiu CT, Scheuing L, Leng Y, Liao HM, Maric D, Chuang DM. Preconditioning mesenchymal stem cells with the mood stabilizers lithium and valproic acid enhances therapeutic efficacy in a mouse model of Huntington's disease. Experimental Neurology. PMID 27085395 DOI: 10.1016/j.expneurol.2016.04.003  0.52
2016 Wang Z, Leng Y, Wang J, Liao HM, Bergman J, Leeds P, Kozikowski A, Chuang DM. Tubastatin A, an HDAC6 inhibitor, alleviates stroke-induced brain infarction and functional deficits: potential roles of α-tubulin acetylation and FGF-21 up-regulation. Scientific Reports. 6: 19626. PMID 26790818 DOI: 10.1038/srep19626  0.52
2015 Yin X, Ren M, Jiang H, Cui S, Wang S, Jiang H, Qi Y, Wang J, Wang X, Dong G, Leeds P, Chuang DM, Feng H. Downregulated AEG-1 together with inhibited PI3K/Akt pathway is associated with reduced viability of motor neurons in an ALS model. Molecular and Cellular Neurosciences. PMID 26320681 DOI: 10.1016/j.mcn.2015.08.009  0.52
2015 Scheuing L, Chiu CT, Liao HM, Chuang DM. Antidepressant mechanism of ketamine: perspective from preclinical studies. Frontiers in Neuroscience. 9: 249. PMID 26257598 DOI: 10.3389/fnins.2015.00249  0.52
2015 Hunsberger JG, Chibane FL, Elkahloun AG, Henderson R, Singh R, Lawson J, Cruceanu C, Nagarajan V, Turecki G, Squassina A, Medeiros CD, Del Zompo M, Rouleau GA, Alda M, Chuang DM. Novel integrative genomic tool for interrogating lithium response in bipolar disorder. Translational Psychiatry. 5: e504. PMID 25646593 DOI: 10.1038/tp.2014.139  0.52
2015 Chiu CT, Scheuing L, Liu G, Liao HM, Linares GR, Lin D, Chuang DM. The mood stabilizer lithium potentiates the antidepressant-like effects and ameliorates oxidative stress induced by acute ketamine in a mouse model of stress. The International Journal of Neuropsychopharmacology / Official Scientific Journal of the Collegium Internationale Neuropsychopharmacologicum (Cinp). 18. PMID 25548109 DOI: 10.1093/ijnp/pyu102  0.52
2014 Lee JT, Chou CH, Cho NY, Sung YF, Yang FC, Chen CY, Lai YH, Chiang CI, Chu CM, Lin JC, Hsu YD, Hong JS, Peng GS, Chuang DM. Post-insult valproate treatment potentially improved functional recovery in patients with acute middle cerebral artery infarction. American Journal of Translational Research. 6: 820-30. PMID 25628792  0.52
2014 Huang F, Zhang L, Long Z, Chen Z, Hou X, Wang C, Peng H, Wang J, Li J, Duan R, Xia K, Chuang DM, Tang B, Jiang H. miR-25 alleviates polyQ-mediated cytotoxicity by silencing ATXN3. Febs Letters. 588: 4791-8. PMID 25451224 DOI: 10.1016/j.febslet.2014.11.013  0.52
2014 Scheuing L, Chiu CT, Liao HM, Linares GR, Chuang DM. Preclinical and clinical investigations of mood stabilizers for Huntington's disease: what have we learned? International Journal of Biological Sciences. 10: 1024-38. PMID 25285035 DOI: 10.7150/ijbs.9898  0.52
2014 Kim HJ, Chuang DM. HDAC inhibitors mitigate ischemia-induced oligodendrocyte damage: potential roles of oligodendrogenesis, VEGF, and anti-inflammation. American Journal of Translational Research. 6: 206-23. PMID 24936215  0.52
2014 Leeds PR, Yu F, Wang Z, Chiu CT, Zhang Y, Leng Y, Linares GR, Chuang DM. A new avenue for lithium: intervention in traumatic brain injury. Acs Chemical Neuroscience. 5: 422-33. PMID 24697257 DOI: 10.1021/cn500040g  0.52
2013 Yu F, Wang Z, Tanaka M, Chiu CT, Leeds P, Zhang Y, Chuang DM. Posttrauma cotreatment with lithium and valproate: reduction of lesion volume, attenuation of blood-brain barrier disruption, and improvement in motor coordination in mice with traumatic brain injury. Journal of Neurosurgery. 119: 766-73. PMID 23848820 DOI: 10.3171/2013.6.JNS13135  0.52
2013 Hunsberger JG, Fessler EB, Chibane FL, Leng Y, Maric D, Elkahloun AG, Chuang DM. Mood stabilizer-regulated miRNAs in neuropsychiatric and neurodegenerative diseases: identifying associations and functions. American Journal of Translational Research. 5: 450-64. PMID 23724168  0.52
2013 Fessler EB, Chibane FL, Wang Z, Chuang DM. Potential roles of HDAC inhibitors in mitigating ischemia-induced brain damage and facilitating endogenous regeneration and recovery. Current Pharmaceutical Design. 19: 5105-20. PMID 23448466 DOI: 10.2174/1381612811319280009  0.52
2013 Lu WH, Wang CY, Chen PS, Wang JW, Chuang DM, Yang CS, Tzeng SF. Valproic acid attenuates microgliosis in injured spinal cord and purinergic P2X4 receptor expression in activated microglia. Journal of Neuroscience Research. 91: 694-705. PMID 23404572 DOI: 10.1002/jnr.23200  0.52
2013 Chiu CT, Wang Z, Hunsberger JG, Chuang DM. Therapeutic potential of mood stabilizers lithium and valproic acid: beyond bipolar disorder. Pharmacological Reviews. 65: 105-42. PMID 23300133 DOI: 10.1124/pr.111.005512  0.52
2013 Leng Y, Fessler EB, Chuang DM. Neuroprotective effects of the mood stabilizer lamotrigine against glutamate excitotoxicity: roles of chromatin remodelling and Bcl-2 induction. The International Journal of Neuropsychopharmacology / Official Scientific Journal of the Collegium Internationale Neuropsychopharmacologicum (Cinp). 16: 607-20. PMID 22564541 DOI: 10.1017/S1461145712000429  0.52
2012 Hunsberger JG, Fessler EB, Wang Z, Elkahloun AG, Chuang DM. Post-insult valproic acid-regulated microRNAs: potential targets for cerebral ischemia. American Journal of Translational Research. 4: 316-32. PMID 22937209  0.52
2012 Wang Z, Tsai LK, Munasinghe J, Leng Y, Fessler EB, Chibane F, Leeds P, Chuang DM. Chronic valproate treatment enhances postischemic angiogenesis and promotes functional recovery in a rat model of ischemic stroke. Stroke; a Journal of Cerebral Circulation. 43: 2430-6. PMID 22811460 DOI: 10.1161/STROKEAHA.112.652545  0.52
2012 Yu F, Zhang Y, Chuang DM. Lithium reduces BACE1 overexpression, β amyloid accumulation, and spatial learning deficits in mice with traumatic brain injury. Journal of Neurotrauma. 29: 2342-51. PMID 22583494 DOI: 10.1089/neu.2012.2449  0.52
2012 Yu F, Wang Z, Tchantchou F, Chiu CT, Zhang Y, Chuang DM. Lithium ameliorates neurodegeneration, suppresses neuroinflammation, and improves behavioral performance in a mouse model of traumatic brain injury. Journal of Neurotrauma. 29: 362-74. PMID 21895523 DOI: 10.1089/neu.2011.1942  0.52
2012 Liu HC, Leu SJ, Chuang DM. Roles of Glycogen Synthase Kinase-3 in Alzheimer's Disease: From Pathology to Treatment Target Journal of Experimental and Clinical Medicine. 4: 135-139. DOI: 10.1016/j.jecm.2012.04.001  0.52
2011 Wang ZF, Fessler EB, Chuang DM. Beneficial effects of mood stabilizers lithium, valproate and lamotrigine in experimental stroke models. Acta Pharmacologica Sinica. 32: 1433-45. PMID 22056617 DOI: 10.1038/aps.2011.140  0.52
2011 Tsai LK, Wang Z, Munasinghe J, Leng Y, Leeds P, Chuang DM. Mesenchymal stem cells primed with valproate and lithium robustly migrate to infarcted regions and facilitate recovery in a stroke model. Stroke; a Journal of Cerebral Circulation. 42: 2932-9. PMID 21836090 DOI: 10.1161/STROKEAHA.110.612788  0.52
2011 Chiu CT, Liu G, Leeds P, Chuang DM. Combined treatment with the mood stabilizers lithium and valproate produces multiple beneficial effects in transgenic mouse models of Huntington's disease. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 36: 2406-21. PMID 21796107 DOI: 10.1038/npp.2011.128  0.52
2011 Chiu CT, Chuang DM. Neuroprotective action of lithium in disorders of the central nervous system. Zhong Nan Da Xue Xue Bao. Yi Xue Ban = Journal of Central South University. Medical Sciences. 36: 461-76. PMID 21743136 DOI: 10.3969/j.issn.1672-7347.2011.06.001  0.52
2011 Hunsberger JG, Machado-Vieira R, Austin DR, Zarate C, Chuang DM, Chen G, Reed JC, Manji HK. Bax inhibitor 1, a modulator of calcium homeostasis, confers affective resilience. Brain Research. 1403: 19-27. PMID 21718971 DOI: 10.1016/j.brainres.2011.05.067  0.52
2011 Benicky J, Sánchez-Lemus E, Honda M, Pang T, Orecna M, Wang J, Leng Y, Chuang DM, Saavedra JM. Angiotensin II AT1 receptor blockade ameliorates brain inflammation. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 36: 857-70. PMID 21150913 DOI: 10.1038/npp.2010.225  0.52
2011 Wang Z, Leng Y, Tsai LK, Leeds P, Chuang DM. Valproic acid attenuates blood-brain barrier disruption in a rat model of transient focal cerebral ischemia: the roles of HDAC and MMP-9 inhibition. Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism. 31: 52-7. PMID 20978517 DOI: 10.1038/jcbfm.2010.195  0.52
2011 Marinova Z, Leng Y, Leeds P, Chuang DM. Histone deacetylase inhibition alters histone methylation associated with heat shock protein 70 promoter modifications in astrocytes and neurons. Neuropharmacology. 60: 1109-15. PMID 20888352 DOI: 10.1016/j.neuropharm.2010.09.022  0.52
2011 Omata N, Chiu CT, Moya PR, Leng Y, Wang Z, Hunsberger JG, Leeds P, Chuang DM. Lentivirally mediated GSK-3β silencing in the hippocampal dentate gyrus induces antidepressant-like effects in stressed mice. The International Journal of Neuropsychopharmacology / Official Scientific Journal of the Collegium Internationale Neuropsychopharmacologicum (Cinp). 14: 711-7. PMID 20604988 DOI: 10.1017/S1461145710000726  0.52
2011 Liu ZH, Chuang DM, Smith CB. Lithium ameliorates phenotypic deficits in a mouse model of fragile X syndrome. The International Journal of Neuropsychopharmacology / Official Scientific Journal of the Collegium Internationale Neuropsychopharmacologicum (Cinp). 14: 618-30. PMID 20497624 DOI: 10.1017/S1461145710000520  0.52
2010 Chiu CT, Chuang DM. Molecular actions and therapeutic potential of lithium in preclinical and clinical studies of CNS disorders. Pharmacology & Therapeutics. 128: 281-304. PMID 20705090 DOI: 10.1016/j.pharmthera.2010.07.006  0.52
2010 Tsai LK, Leng Y, Wang Z, Leeds P, Chuang DM. The mood stabilizers valproic acid and lithium enhance mesenchymal stem cell migration via distinct mechanisms. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 35: 2225-37. PMID 20613717 DOI: 10.1038/npp.2010.97  0.52
2010 Leng Y, Marinova Z, Reis-Fernandes MA, Nau H, Chuang DM. Potent neuroprotective effects of novel structural derivatives of valproic acid: potential roles of HDAC inhibition and HSP70 induction. Neuroscience Letters. 476: 127-32. PMID 20394799 DOI: 10.1016/j.neulet.2010.04.013  0.52
2009 Chuang DM, Leng Y, Marinova Z, Kim HJ, Chiu CT. Multiple roles of HDAC inhibition in neurodegenerative conditions. Trends in Neurosciences. 32: 591-601. PMID 19775759 DOI: 10.1016/j.tins.2009.06.002  0.52
2009 Marinova Z, Ren M, Wendland JR, Leng Y, Liang MH, Yasuda S, Leeds P, Chuang DM. Valproic acid induces functional heat-shock protein 70 via Class I histone deacetylase inhibition in cortical neurons: a potential role of Sp1 acetylation. Journal of Neurochemistry. 111: 976-87. PMID 19765194 DOI: 10.1111/j.1471-4159.2009.06385.x  0.52
2009 Kim HJ, Leeds P, Chuang DM. The HDAC inhibitor, sodium butyrate, stimulates neurogenesis in the ischemic brain. Journal of Neurochemistry. 110: 1226-40. PMID 19549282 DOI: 10.1111/j.1471-4159.2009.06212.x  0.52
2009 Guo S, Arai K, Stins MF, Chuang DM, Lo EH. Lithium upregulates vascular endothelial growth factor in brain endothelial cells and astrocytes. Stroke; a Journal of Cerebral Circulation. 40: 652-5. PMID 18974377 DOI: 10.1161/STROKEAHA.108.524504  0.52
2009 Yasuda S, Liang MH, Marinova Z, Yahyavi A, Chuang DM. The mood stabilizers lithium and valproate selectively activate the promoter IV of brain-derived neurotrophic factor in neurons. Molecular Psychiatry. 14: 51-9. PMID 17925795 DOI: 10.1038/  0.52
2008 Feng HL, Leng Y, Ma CH, Zhang J, Ren M, Chuang DM. Combined lithium and valproate treatment delays disease onset, reduces neurological deficits and prolongs survival in an amyotrophic lateral sclerosis mouse model. Neuroscience. 155: 567-72. PMID 18640245 DOI: 10.1016/j.neuroscience.2008.06.040  0.52
2008 Wu X, Chen PS, Dallas S, Wilson B, Block ML, Wang CC, Kinyamu H, Lu N, Gao X, Leng Y, Chuang DM, Zhang W, Lu RB, Hong JS. Histone deacetylase inhibitors up-regulate astrocyte GDNF and BDNF gene transcription and protect dopaminergic neurons. The International Journal of Neuropsychopharmacology / Official Scientific Journal of the Collegium Internationale Neuropsychopharmacologicum (Cinp). 11: 1123-34. PMID 18611290 DOI: 10.1017/S1461145708009024  0.52
2008 Leng Y, Liang MH, Ren M, Marinova Z, Leeds P, Chuang DM. Synergistic neuroprotective effects of lithium and valproic acid or other histone deacetylase inhibitors in neurons: roles of glycogen synthase kinase-3 inhibition. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 28: 2576-88. PMID 18322101 DOI: 10.1523/JNEUROSCI.5467-07.2008  0.52
2008 Kim YR, van Meer MP, Tejima E, Murata Y, Mandeville JB, Dai G, Chuang DM, Rosen BR, Lo EH. Functional MRI of delayed chronic lithium treatment in rat focal cerebral ischemia. Stroke; a Journal of Cerebral Circulation. 39: 439-47. PMID 18187690 DOI: 10.1161/STROKEAHA.107.492215  0.52
2008 Liang MH, Wendland JR, Chuang DM. Lithium inhibits Smad3/4 transactivation via increased CREB activity induced by enhanced PKA and AKT signaling. Molecular and Cellular Neurosciences. 37: 440-53. PMID 18077182 DOI: 10.1016/j.mcn.2007.10.017  0.52
2007 Bian Q, Shi T, Chuang DM, Qian Y. Lithium reduces ischemia-induced hippocampal CA1 damage and behavioral deficits in gerbils. Brain Research. 1184: 270-6. PMID 18028886 DOI: 10.1016/j.brainres.2007.09.054  0.52
2007 Chen PS, Wang CC, Bortner CD, Peng GS, Wu X, Pang H, Lu RB, Gean PW, Chuang DM, Hong JS. Valproic acid and other histone deacetylase inhibitors induce microglial apoptosis and attenuate lipopolysaccharide-induced dopaminergic neurotoxicity. Neuroscience. 149: 203-12. PMID 17850978 DOI: 10.1016/j.neuroscience.2007.06.053  0.52
2007 Chuang DM, Manji HK. In search of the Holy Grail for the treatment of neurodegenerative disorders: has a simple cation been overlooked? Biological Psychiatry. 62: 4-6. PMID 17572175 DOI: 10.1016/j.biopsych.2007.04.008  0.52
2007 Rowe MK, Wiest C, Chuang DM. GSK-3 is a viable potential target for therapeutic intervention in bipolar disorder. Neuroscience and Biobehavioral Reviews. 31: 920-31. PMID 17499358 DOI: 10.1016/j.neubiorev.2007.03.002  0.52
2007 Liang ZQ, Wang X, Li LY, Wang Y, Chen RW, Chuang DM, Chase TN, Qin ZH. Nuclear factor-kappaB-dependent cyclin D1 induction and DNA replication associated with N-methyl-D-aspartate receptor-mediated apoptosis in rat striatum. Journal of Neuroscience Research. 85: 1295-309. PMID 17385714 DOI: 10.1002/jnr.21248  0.52
2007 Kim HJ, Rowe M, Ren M, Hong JS, Chen PS, Chuang DM. Histone deacetylase inhibitors exhibit anti-inflammatory and neuroprotective effects in a rat permanent ischemic model of stroke: multiple mechanisms of action. The Journal of Pharmacology and Experimental Therapeutics. 321: 892-901. PMID 17371805 DOI: 10.1124/jpet.107.120188  0.52
2007 Liang MH, Chuang DM. Regulation and function of glycogen synthase kinase-3 isoforms in neuronal survival. The Journal of Biological Chemistry. 282: 3904-17. PMID 17148450 DOI: 10.1074/jbc.M605178200  0.52
2007 Imaizumi M, Kim HJ, Zoghbi SS, Briard E, Hong J, Musachio JL, Ruetzler C, Chuang DM, Pike VW, Innis RB, Fujita M. PET imaging with [11C]PBR28 can localize and quantify upregulated peripheral benzodiazepine receptors associated with cerebral ischemia in rat. Neuroscience Letters. 411: 200-5. PMID 17127001 DOI: 10.1016/j.neulet.2006.09.093  0.52
2007 Senatorov VV, Chuang DM. Lithium protects against quinolinic acid-induced excitotoxicity in rat corticostriatal organotypic culture International Journal of Neuroprotection and Neuroregeneration. 3: 122-132.  0.52
2006 Chen PS, Peng GS, Li G, Yang S, Wu X, Wang CC, Wilson B, Lu RB, Gean PW, Chuang DM, Hong JS. Valproate protects dopaminergic neurons in midbrain neuron/glia cultures by stimulating the release of neurotrophic factors from astrocytes. Molecular Psychiatry. 11: 1116-25. PMID 16969367 DOI: 10.1038/  0.52
2006 Liang MH, Chuang DM. Differential roles of glycogen synthase kinase-3 isoforms in the regulation of transcriptional activation. The Journal of Biological Chemistry. 281: 30479-84. PMID 16912034 DOI: 10.1074/jbc.M607468200  0.52
2006 Leng Y, Chuang DM. Endogenous alpha-synuclein is induced by valproic acid through histone deacetylase inhibition and participates in neuroprotection against glutamate-induced excitotoxicity. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 26: 7502-12. PMID 16837598 DOI: 10.1523/JNEUROSCI.0096-06.2006  0.52
2005 Chuang DM. The antiapoptotic actions of mood stabilizers: molecular mechanisms and therapeutic potentials. Annals of the New York Academy of Sciences. 1053: 195-204. PMID 16179524 DOI: 10.1196/annals.1344.018  0.52
2005 Liang ZQ, Wang XX, Wang Y, Chuang DM, DiFiglia M, Chase TN, Qin ZH. Susceptibility of striatal neurons to excitotoxic injury correlates with basal levels of Bcl-2 and the induction of P53 and c-Myc immunoreactivity. Neurobiology of Disease. 20: 562-73. PMID 15922606 DOI: 10.1016/j.nbd.2005.04.011  0.52
2005 Chuang DM, Hough C, Senatorov VV. Glyceraldehyde-3-phosphate dehydrogenase, apoptosis, and neurodegenerative diseases. Annual Review of Pharmacology and Toxicology. 45: 269-90. PMID 15822178 DOI: 10.1146/annurev.pharmtox.45.120403.095902  0.52
2005 Peng GS, Li G, Tzeng NS, Chen PS, Chuang DM, Hsu YD, Yang S, Hong JS. Valproate pretreatment protects dopaminergic neurons from LPS-induced neurotoxicity in rat primary midbrain cultures: role of microglia. Brain Research. Molecular Brain Research. 134: 162-9. PMID 15790540 DOI: 10.1016/j.molbrainres.2004.10.021  0.52
2005 Hiroi T, Wei H, Hough C, Leeds P, Chuang DM. Protracted lithium treatment protects against the ER stress elicited by thapsigargin in rat PC12 cells: roles of intracellular calcium, GRP78 and Bcl-2. The Pharmacogenomics Journal. 5: 102-11. PMID 15668729 DOI: 10.1038/sj.tpj.6500296  0.52
2005 Leeds P, Leng Y, Chalecka-Franaszek E, Chuang DM. Neurotrophins protect against cytosine arabinoside-induced apoptosis of immature rat cerebellar neurons. Neurochemistry International. 46: 61-72. PMID 15567516 DOI: 10.1016/j.neuint.2004.07.001  0.52
2004 Chuang DM. Neuroprotective and neurotrophic actions of the mood stabilizer lithium: can it be used to treat neurodegenerative diseases? Critical Reviews in Neurobiology. 16: 83-90. PMID 15581403 DOI: 10.1615/CritRevNeurobiol.v16.i12.90  0.52
2004 Rowe MK, Chuang DM. Lithium neuroprotection: molecular mechanisms and clinical implications. Expert Reviews in Molecular Medicine. 6: 1-18. PMID 15488156 DOI: 10.1017/S1462399404008385  0.52
2004 Kanai H, Sawa A, Chen RW, Leeds P, Chuang DM. Valproic acid inhibits histone deacetylase activity and suppresses excitotoxicity-induced GAPDH nuclear accumulation and apoptotic death in neurons. The Pharmacogenomics Journal. 4: 336-44. PMID 15289798 DOI: 10.1038/sj.tpj.6500269  0.52
2004 Ren M, Leng Y, Jeong M, Leeds PR, Chuang DM. Valproic acid reduces brain damage induced by transient focal cerebral ischemia in rats: potential roles of histone deacetylase inhibition and heat shock protein induction. Journal of Neurochemistry. 89: 1358-67. PMID 15189338 DOI: 10.1111/j.1471-4159.2004.02406.x  0.52
2004 Senatorov VV, Ren M, Kanai H, Wei H, Chuang DM. Short-term lithium treatment promotes neuronal survival and proliferation in rat striatum infused with quinolinic acid, an excitotoxic model of Huntington's disease. Molecular Psychiatry. 9: 371-85. PMID 14702090 DOI: 10.1038/  0.52
2004 Chuang DM. Lithium protection from glutamate excitotoxicity: Therapeutic implications Clinical Neuroscience Research. 4: 243-252. DOI: 10.1016/j.cnr.2004.09.016  0.52
2003 Ren M, Senatorov VV, Chen RW, Chuang DM. Postinsult treatment with lithium reduces brain damage and facilitates neurological recovery in a rat ischemia/reperfusion model. Proceedings of the National Academy of Sciences of the United States of America. 100: 6210-5. PMID 12732732 DOI: 10.1073/pnas.0937423100  0.52
2003 Jeong MR, Hashimoto R, Senatorov VV, Fujimaki K, Ren M, Lee MS, Chuang DM. Valproic acid, a mood stabilizer and anticonvulsant, protects rat cerebral cortical neurons from spontaneous cell death: a role of histone deacetylase inhibition. Febs Letters. 542: 74-8. PMID 12729901 DOI: 10.1016/S0014-5793(03)00350-8  0.52
2003 Hashimoto R, Fujimaki K, Jeong MR, Senatorov VV, Christ L, Leeds P, Chuang DM, Takeda M. [Neuroprotective actions of lithium]. Seishin Shinkeigaku Zasshi = Psychiatria Et Neurologia Japonica. 105: 81-6. PMID 12701214  0.52
2003 Senatorov VV, Charles V, Reddy PH, Tagle DA, Chuang DM. Overexpression and nuclear accumulation of glyceraldehyde-3-phosphate dehydrogenase in a transgenic mouse model of Huntington's disease. Molecular and Cellular Neurosciences. 22: 285-97. PMID 12691731 DOI: 10.1016/S1044-7431(02)00013-1  0.52
2003 Hashimoto R, Fujimaki K, Jeong MR, Christ L, Chuang DM. Lithium-induced inhibition of Src tyrosine kinase in rat cerebral cortical neurons: a role in neuroprotection against N-methyl-D-aspartate receptor-mediated excitotoxicity. Febs Letters. 538: 145-8. PMID 12633868 DOI: 10.1016/S0014-5793(03)00167-4  0.52
2003 Hashimoto R, Senatorov V, Kanai H, Leeds P, Chuang DM. Lithium stimulates progenitor proliferation in cultured brain neurons. Neuroscience. 117: 55-61. PMID 12605892 DOI: 10.1016/S0306-4522(02)00577-8  0.52
2003 Kopnisky KL, Chalecka-Franaszek E, Gonzalez-Zulueta M, Chuang DM. Chronic lithium treatment antagonizes glutamate-induced decrease of phosphorylated CREB in neurons via reducing protein phosphatase 1 and increasing MEK activities. Neuroscience. 116: 425-35. PMID 12559097 DOI: 10.1016/S0306-4522(02)00573-0  0.52
2003 Chen RW, Qin ZH, Ren M, Kanai H, Chalecka-Franaszek E, Leeds P, Chuang DM. Regulation of c-Jun N-terminal kinase, p38 kinase and AP-1 DNA binding in cultured brain neurons: roles in glutamate excitotoxicity and lithium neuroprotection. Journal of Neurochemistry. 84: 566-75. PMID 12558976 DOI: 10.1046/j.1471-4159.2003.01548.x  0.52
2002 Hashimoto R, Takei N, Shimazu K, Christ L, Lu B, Chuang DM. Lithium induces brain-derived neurotrophic factor and activates TrkB in rodent cortical neurons: an essential step for neuroprotection against glutamate excitotoxicity. Neuropharmacology. 43: 1173-9. PMID 12504924 DOI: 10.1016/S0028-3908(02)00217-4  0.52
2002 Chuang DM, Chen RW, Chalecka-Franaszek E, Ren M, Hashimoto R, Senatorov V, Kanai H, Hough C, Hiroi T, Leeds P. Neuroprotective effects of lithium in cultured cells and animal models of diseases. Bipolar Disorders. 4: 129-36. PMID 12071510 DOI: 10.1034/j.1399-5618.2002.01179.x  0.52
2002 Hashimoto R, Hough C, Nakazawa T, Yamamoto T, Chuang DM. Lithium protection against glutamate excitotoxicity in rat cerebral cortical neurons: involvement of NMDA receptor inhibition possibly by decreasing NR2B tyrosine phosphorylation. Journal of Neurochemistry. 80: 589-97. PMID 11841566 DOI: 10.1046/j.0022-3042.2001.00728.x  0.52
2001 Wei H, Qin ZH, Senatorov VV, Wei W, Wang Y, Qian Y, Chuang DM. Lithium suppresses excitotoxicity-induced striatal lesions in a rat model of Huntington's disease. Neuroscience. 106: 603-12. PMID 11591460 DOI: 10.1016/S0306-4522(01)00311-6  0.52
2001 Qin ZH, Wang Y, Chen RW, Wang X, Ren M, Chuang DM, Chase TN. Prostaglandin A(1) protects striatal neurons against excitotoxic injury in rat striatum. The Journal of Pharmacology and Experimental Therapeutics. 297: 78-87. PMID 11259530  0.52
2001 Chuang DM. Emerging role of lithium as a neuroprotective drug: Therapeutic implications Annals of the New York Academy of Sciences. 939: 404.  0.52
2000 Wei H, Leeds P, Chen RW, Wei W, Leng Y, Bredesen DE, Chuang DM. Neuronal apoptosis induced by pharmacological concentrations of 3-hydroxykynurenine: characterization and protection by dantrolene and Bcl-2 overexpression. Journal of Neurochemistry. 75: 81-90. PMID 10854250 DOI: 10.1046/j.1471-4159.2000.0750081.x  0.52
2000 Wei H, Leeds PR, Qian Y, Wei W, Chen RW, Chuang DM. β-Amyloid peptide-induced death of PC 12 cells and cerebellar granule cell neurons is inhibited by long-term lithium treatment European Journal of Pharmacology. 392: 117-123. PMID 10762662 DOI: 10.1016/S0014-2999(00)00127-8  0.52
1999 Wang Y, Qin ZH, Nakai M, Chen RW, Chuang DM, Chase TN. Co-stimulation of cyclic-AMP-linked metabotropic glutamate receptors in rat striatum attenuates excitotoxin-induced nuclear factor-kappaB activation and apoptosis. Neuroscience. 94: 1153-62. PMID 10625054 DOI: 10.1016/S0306-4522(99)00264-X  0.52
1999 Chen RW, Saunders PA, Wei H, Li Z, Seth P, Chuang DM. Involvement of glyceraldehyde-3-phosphate dehydrogenase (GAPDH) and p53 in neuronal apoptosis: evidence that GAPDH is upregulated by p53. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 19: 9654-62. PMID 10531467  0.52
1999 Hough C, Lu SJ, Davis CL, Chuang DM, Post RM. Elevated basal and thapsigargin-stimulated intracellular calcium of platelets and lymphocytes from bipolar affective disorder patients measured by a fluorometric microassay. Biological Psychiatry. 46: 247-55. PMID 10418700 DOI: 10.1016/S0006-3223(98)00308-4  0.52
1999 Chalecka-Franaszek E, Chuang DM. Lithium activates the serine/threonine kinase Akt-1 and suppresses glutamate-induced inhibition of Akt-1 activity in neurons. Proceedings of the National Academy of Sciences of the United States of America. 96: 8745-50. PMID 10411946 DOI: 10.1073/pnas.96.15.8745  0.52
1999 Chalecka-Franaszek E, Chen H, Chuang DM. 5-Hydroxytryptamine2A receptor stimulation induces activator protein-1 and cyclic AMP-responsive element binding with cyclic AMP-responsive element-binding protein and Jun D as common components in cerebellar neurons. Neuroscience. 88: 885-98. PMID 10363825 DOI: 10.1016/S0306-4522(98)00269-3  0.52
1999 Qin ZH, Chen RW, Wang Y, Nakai M, Chuang DM, Chase TN. Nuclear factor kappaB nuclear translocation upregulates c-Myc and p53 expression during NMDA receptor-mediated apoptosis in rat striatum. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 19: 4023-33. PMID 10234031  0.52
1999 Mason RP, Leeds PR, Jacob RF, Hough CJ, Zhang KG, Mason PE, Chuang DM. Inhibition of excessive neuronal apoptosis by the calcium antagonist amlodipine and antioxidants in cerebellar granule cells. Journal of Neurochemistry. 72: 1448-56. PMID 10098848 DOI: 10.1046/j.1471-4159.1999.721448.x  0.52
1999 Chen RW, Chuang DM. Long term lithium treatment suppresses p53 and Bax expression but increases Bcl-2 expression. A prominent role in neuroprotection against excitotoxicity. The Journal of Biological Chemistry. 274: 6039-42. PMID 10037682 DOI: 10.1074/jbc.274.10.6039  0.52
1999 Saunders PA, Chen RW, Chuang DM. Nuclear translocation of glyceraldehyde-3-phosphate dehydrogenase isoforms during neuronal apoptosis. Journal of Neurochemistry. 72: 925-32. PMID 10037463 DOI: 10.1046/j.1471-4159.1999.0720925.x  0.52
1999 Katsube N, Sunaga K, Aishita H, Chuang DM, Ishitani R. ONO-1603, a potential antidementia drug, delays age-induced apoptosis and suppresses overexpression of glyceraldehyde-3-phosphate dehydrogenase in cultured central nervous system neurons. The Journal of Pharmacology and Experimental Therapeutics. 288: 6-13. PMID 9862746  0.52
1998 Nonaka S, Chuang DM. Neuroprotective effects of chronic lithium on focal cerebral ischemia in rats. Neuroreport. 9: 2081-4. PMID 9674597  0.52
1998 Nonaka S, Katsube N, Chuang DM. Lithium protects rat cerebellar granule cells against apoptosis induced by anticonvulsants, phenytoin and carbamazepine. The Journal of Pharmacology and Experimental Therapeutics. 286: 539-47. PMID 9655900  0.52
1998 Ishitani R, Tanaka M, Sunaga K, Katsube N, Chuang DM. Nuclear localization of overexpressed glyceraldehyde-3-phosphate dehydrogenase in cultured cerebellar neurons undergoing apoptosis. Molecular Pharmacology. 53: 701-7. PMID 9547361  0.52
1998 Nonaka S, Hough CJ, Chuang DM. Chronic lithium treatment robustly protects neurons in the central nervous system against excitotoxicity by inhibiting N-methyl-D-aspartate receptor-mediated calcium influx. Proceedings of the National Academy of Sciences of the United States of America. 95: 2642-7. PMID 9482940 DOI: 10.1073/pnas.95.5.2642  0.52
1998 Li H, Weiss SR, Chuang DM, Post RM, Rogawski MA. Bidirectional synaptic plasticity in the rat basolateral amygdala: characterization of an activity-dependent switch sensitive to the presynaptic metabotropic glutamate receptor antagonist 2S-alpha-ethylglutamic acid. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 18: 1662-70. PMID 9464991  0.52
1998 Fukamauchi F, Wang YJ, Chuang DM. Ethanol induces subtype-specific up-regulation of muscarinic acetylcholine receptor mRNA in neurohybrid cell lines. Life Sciences. 62: 389-96. PMID 9449229 DOI: 10.1016/S0024-3205(97)01132-6  0.52
1997 Xing G, Zhang L, Zhang L, Heynen T, Li XL, Smith MA, Weiss SR, Feldman AN, Detera-Wadleigh S, Chuang DM, Post RM. Rat nurr1 is prominently expressed in perirhinal cortex, and differentially induced in the hippocampal dentate gyrus by electroconvulsive vs. kindled seizures. Brain Research. Molecular Brain Research. 47: 251-61. PMID 9221923 DOI: 10.1016/S0169-328X(97)00056-9  0.52
1997 Lin WW, Wang CW, Chuang DM. Effects of depolarization and NMDA antagonists on the role survival of cerebellar granule cells: a pivotal role for protein kinase C isoforms. Journal of Neurochemistry. 68: 2577-86. PMID 9166755  0.52
1997 Yu O, Chuang DM. Neurotrophin protection against toxicity induced by low potassium and nitroprusside in cultured cerebellar granule neurons. Journal of Neurochemistry. 68: 68-77. PMID 8978711  0.52
1996 Chuang DM, Ishitani R. A role for GAPDH in apoptosis and neurodegeneration. Nature Medicine. 2: 609-10. PMID 8640541 DOI: 10.1038/nm0696-609  0.52
1996 Hough CJ, Irwin RP, Gao XM, Rogawski MA, Chuang DM. Carbamazepine inhibition of N-methyl-D-aspartate-evoked calcium influx in rat cerebellar granule cells. The Journal of Pharmacology and Experimental Therapeutics. 276: 143-9. PMID 8558424  0.52
1996 Yu O, Chuang DM. Inhibition of excitatory amino acid-induced phosphoinositide hydrolysis as a possible mechanism of nitroprusside neurotoxicity. Journal of Neurochemistry. 66: 346-54. PMID 8522973  0.52
1995 Gao XM, Margolis RL, Leeds P, Hough C, Post RM, Chuang DM. Carbamazepine induction of apoptosis in cultured cerebellar neurons: effects of N-methyl-D-aspartate, aurintricarboxylic acid and cycloheximide. Brain Research. 703: 63-71. PMID 8719616 DOI: 10.1016/0006-8993(95)01066-1  0.52
1995 Belcheva MM, Gucker S, Chuang DM, Clark WG, Jefcoat LB, McHale RJ, Toth G, Borsodi A, Coscia CJ. Modulation of opioid binding associated with nuclear matrix and nuclear membranes of NG108-15 cells. The Journal of Pharmacology and Experimental Therapeutics. 274: 1513-23. PMID 7562528  0.52
1995 Chen H, Zhang L, Rubinow DR, Chuang DM. Chronic buspirone treatment differentially regulates 5-HT1A and 5-HT2A receptor mRNA and binding sites in various regions of the rat hippocampus. Brain Research. Molecular Brain Research. 32: 348-53. PMID 7500848 DOI: 10.1016/0169-328X(95)00098-D  0.52
1995 Chen H, Li H, Chuang DM. Role of second messengers in agonist up-regulation of 5-HT2A (5-HT2) receptor binding sites in cerebellar granule neurons: involvement of calcium influx and a calmodulin-dependent pathway. The Journal of Pharmacology and Experimental Therapeutics. 275: 674-80. PMID 7473154  0.4
1994 Margolis RL, Chuang DM, Post RM. Programmed cell death: implications for neuropsychiatric disorders. Biological Psychiatry. 35: 946-56. PMID 8080894  0.56
1994 Lin WW, Chuang DM. Different signal transduction pathways are coupled to the nucleotide receptor and the P2Y receptor in C6 glioma cells. The Journal of Pharmacology and Experimental Therapeutics. 269: 926-31. PMID 8014879  0.52
1993 Belcheva M, Barg J, Rowinski J, Clark WG, Gloeckner CA, Ho A, Gao XM, Chuang DM, Coscia C. Novel opioid binding sites associated with nuclei of NG108-15 neurohybrid cells. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 13: 104-14. PMID 8423466  0.52
1993 Lin WW, Chuang DM. Agonist-induced desensitization of ATP receptor-mediated phosphoinositide turnover in C6 glioma cells: comparison with the negative-feedback regulation by protein kinase C. Neurochemistry International. 23: 53-60. PMID 8396484 DOI: 10.1016/0197-0186(93)90143-S  0.52
1993 Margolis RL, Chuang DM, Dick D, Weiss SR, Post RM. Effect of cocaine, lidocaine kindling and carbamazepine on batrachotoxin-induced phosphoinositide hydrolysis in rat brain slices. Brain Research. 614: 185-90. PMID 8394185 DOI: 10.1016/0006-8993(93)91033-O  0.52
1993 Lin WW, Chuang DM. Extracellular ATP stimulates inositol phospholipid turnover and calcium influx in C6 glioma cells. Neurochemical Research. 18: 681-7. PMID 8389991 DOI: 10.1007/BF00966782  0.52
1993 Lin WW, Chuang DM. Endothelin- and ATP-induced inhibition of adenylyl cyclase activity in C6 glioma cells: role of Gi and calcium. Molecular Pharmacology. 44: 158-65. PMID 8341270  0.52
1993 Yu O, Chuang DM. Long-term GABA treatment elicits supersensitivity of quisqualate-preferring metabotropic glutamate receptor in cultured rat cerebellar neurons. Journal of Neurochemistry. 61: 430-5. PMID 8101556  0.52
1992 Post RM, Weiss SR, Chuang DM. Mechanisms of action of anticonvulsants in affective disorders: comparisons with lithium. Journal of Clinical Psychopharmacology. 12: 23S-35S. PMID 1541715 DOI: 10.1097/00004714-199202001-00005  0.52
1992 Lesch KP, Hough CJ, Aulakh CS, Wolozin BL, Tolliver TJ, Hill JL, Akiyoshi J, Chuang DM, Murphy DL. Fluoxetine modulates G protein alpha s, alpha q, and alpha 12 subunit mRNA expression in rat brain. European Journal of Pharmacology. 227: 233-7. PMID 1426031 DOI: 10.1016/0922-4106(92)90134-H  0.52
1992 Chuang DM, Gao XM, Paul SM. N-methyl-D-aspartate exposure blocks glutamate toxicity in cultured cerebellar granule cells. Molecular Pharmacology. 42: 210-6. PMID 1355259  0.52
1992 Lin WW, Chuang DM. Regulation of bradykinin-induced phosphoinositide turnover in cultured cerebellar astrocytes: possible role of protein kinase C. Neurochemistry International. 21: 573-9. PMID 1338944 DOI: 10.1016/0197-0186(92)90090-E  0.52
1992 Lin WW, Chuang DM. Potentiation by Ca2+ ionophores and inhibition by extracellular KCl of endothelin-induced phosphoinositide turnover in C6 glioma cells. Neurochemistry International. 21: 293-301. PMID 1338900 DOI: 10.1016/0197-0186(92)90161-J  0.52
1992 Belcheva MM, Barg J, Gloeckner C, Gao XM, Chuang DM, Coscia CJ. Antagonist-induced transient down-regulation of delta-opioid receptors in NG108-15 cells. Molecular Pharmacology. 42: 445-52. PMID 1328845  0.52
1991 Belcheva MM, Barg J, McHale RJ, Gao XM, Chuang DM, Coscia CJ. Up-regulation of delta opioid receptors in neuroblastoma hybrid cells: evidence for differences in the mechanisms of action of sodium butyrate and naltrexone. The Journal of Pharmacology and Experimental Therapeutics. 259: 302-9. PMID 1656025  0.52
1990 Duchemin AM, Quach TT, Schrier BK, Chuang DM, Wyatt RJ. Expression of neurotrophic activity in Xenopus oocytes injected with mRNA from wounded rat cerebral cortex. Brain Research. Molecular Brain Research. 8: 235-41. PMID 2170801 DOI: 10.1016/0169-328X(90)90022-6  0.52
1990 Coscia CJ, Belcheva M, Gao XM, Chuang DM. Effects of up-regulation by butyrate on delta opioid receptor GTP sensitivity and distribution in subcellular compartments. Progress in Clinical and Biological Research. 328: 157-60. PMID 2154771  0.52
1989 Lin WW, Lee CY, Chuang DM. Cross-desensitization of endothelin- and sarafotoxin-induced phosphoinositide turnover in neurons. European Journal of Pharmacology. 166: 581-2. PMID 2553439 DOI: 10.1016/0014-2999(89)90381-6  0.52
1989 McLean S, Rothman RB, Chuang DM, Rice KC, Spain JW, Coscia CJ, Roth BL. Cross-linking of [125I]beta-endorphin to mu-opioid receptors during development. Brain Research. Developmental Brain Research. 45: 283-9. PMID 2540924 DOI: 10.1016/0165-3806(89)90046-1  0.52
1989 Copeland RL, Pradhan SN, Dillon-Carter O, Chuang DM. Rebound increase of basal cAMP level in NG108-15 cells during chronic morphine treatment: effects of naloxone and chloramphenicol. Life Sciences. 44: 1107-16. PMID 2539545 DOI: 10.1016/0024-3205(89)90338-X  0.52
1988 Yu O, Chuang DM. GABA pretreatment enhances glutamate mediated phosphoinositide hydrolysis in neurons. European Journal of Pharmacology. 158: 179-80. PMID 2906009 DOI: 10.1016/0014-2999(88)90272-5  0.52
1986 Chuang DM, Dillon-Carter O, Spain JW, Laskowski MB, Roth BL, Coscia CJ. Detection and characterization of beta-adrenergic receptors and adenylate cyclase in coated vesicles isolated from bovine brain. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 6: 2578-84. PMID 3018196  0.52
1986 Nicoletti F, Meek JL, Iadarola MJ, Chuang DM, Roth BL, Costa E. Coupling of inositol phospholipid metabolism with excitatory amino acid recognition sites in rat hippocampus. Journal of Neurochemistry. 46: 40-6. PMID 2866236 DOI: 10.1111/j.1471-4159.1986.tb12922.x  0.52
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