Reisa Sperling, MD - Publications

Affiliations: 
Harvard University, Cambridge, MA, United States 

409 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2023 Gagliardi G, Rodriguez-Vieitez E, Montal V, Sepulcre J, Diez I, Lois C, Hanseeuw B, Schultz AP, Properzi MJ, Papp KV, Marshall GA, Fortea J, Johnson KA, Sperling RA, Vannini P. Cortical microstructural changes predict tau accumulation and episodic memory decline in older adults harboring amyloid. Communications Medicine. 3: 106. PMID 37528163 DOI: 10.1038/s43856-023-00324-7  0.334
2023 Prokopiou PC, Engels-Domínguez N, Schultz AP, Sepulcre J, Koops EA, Papp KV, Marshall GA, Normandin MD, El Fakhri G, Rentz D, Sperling RA, Johnson KA, Jacobs HIL. Association of Novelty-Related Locus Coeruleus Function With Entorhinal Tau Deposition and Memory Decline in Preclinical Alzheimer Disease. Neurology. PMID 37491329 DOI: 10.1212/WNL.0000000000207646  0.334
2023 Yang HS, Teng L, Kang D, Menon V, Ge T, Finucane HK, Schultz AP, Properzi M, Klein HU, Chibnik LB, Schneider JA, Bennett DA, Hohman TJ, Mayeux RP, Johnson KA, ... ... Sperling RA, et al. Cell-type-specific Alzheimer's disease polygenic risk scores are associated with distinct disease processes in Alzheimer's disease. Medrxiv : the Preprint Server For Health Sciences. PMID 37333223 DOI: 10.1101/2023.06.01.23290850  0.351
2023 Reynolds G, Buckley R, Papp K, Schultz SA, Rentz D, Sperling R, Amariglio R. Relation of modifiable lifestyle and mood factors to cognitive concerns among participants and their study partners in the A4 screen data. Alzheimer's & Dementia (Amsterdam, Netherlands). 15: e12435. PMID 37304049 DOI: 10.1002/dad2.12435  0.305
2023 Schultz SA, Shirzadi Z, Schultz AP, Liu L, Fitzpatrick CD, McDade E, Barthelemy NR, Renton A, Esposito B, Joseph-Mathurin N, Cruchaga C, Chen CD, Goate A, Allegri RF, Benzinger TLS, ... ... Sperling RA, et al. Location of pathogenic variants in PSEN1 impacts progression of cognitive, clinical, and neurodegenerative measures in autosomal-dominant Alzheimer's disease. Aging Cell. e13871. PMID 37291760 DOI: 10.1111/acel.13871  0.33
2023 Gonzalez C, Mimmack KJ, Amariglio RE, Becker JA, Chhatwal JP, Fitzpatrick CD, Gatchel JR, Johnson KA, Katz ZS, Kuppe MK, Locascio JJ, Udeogu OJ, Papp KV, Premnath P, Properzi MJ, ... ... Sperling RA, et al. Associations of the Harvard Automated Phone Task and Alzheimer's Disease Pathology in Cognitively Normal Older Adults: Preliminary Findings. Journal of Alzheimer's Disease : Jad. PMID 37212093 DOI: 10.3233/JAD-220885  0.373
2023 Nho K, Risacher SL, Apostolova L, Bice PJ, Brosch J, Deardorff R, Faber K, Farlow MR, Foroud T, Gao S, Rosewood T, Kim JP, Nudelman K, Yu M, Aisen P, ... Sperling R, et al. Novel Alzheimer's disease locus identified by genome-wide association analysis of cerebral tau deposition on PET. Medrxiv : the Preprint Server For Health Sciences. PMID 36993271 DOI: 10.1101/2023.02.27.23286048  0.302
2023 Young CB, Mormino EC, Poston KL, Johnson KA, Rentz DM, Sperling RA, Papp KV. Computerized cognitive practice effects in relation to amyloid and tau in preclinical Alzheimer's disease: Results from a multi-site cohort. Alzheimer's & Dementia (Amsterdam, Netherlands). 15: e12414. PMID 36950699 DOI: 10.1002/dad2.12414  0.327
2022 Aguillon D, Langella S, Chen Y, Sanchez JS, Su Y, Vila-Castelar C, Vasquez D, Zetterberg H, Hansson O, Dage JL, Janelidze S, Chen K, Fox-Fuller JT, Aduen P, Martinez JE, ... ... Sperling RA, et al. Plasma p-tau217 predicts in vivo brain pathology and cognition in autosomal dominant Alzheimer's disease. Alzheimer's & Dementia : the Journal of the Alzheimer's Association. PMID 36571821 DOI: 10.1002/alz.12906  0.321
2022 Rafii MS, Sperling RA, Donohue MC, Zhou J, Roberts C, Irizarry MC, Dhadda S, Sethuraman G, Kramer LD, Swanson CJ, Li D, Krause S, Rissman RA, Walter S, Raman R, et al. The AHEAD 3-45 Study: Design of a prevention trial for Alzheimer's disease. Alzheimer's & Dementia : the Journal of the Alzheimer's Association. PMID 35971310 DOI: 10.1002/alz.12748  0.323
2022 Insel PS, Young CB, Aisen PS, Johnson KA, Sperling RA, Mormino EC, Donohue MC. Tau positron emission tomography in preclinical Alzheimer's disease. Brain : a Journal of Neurology. PMID 35962782 DOI: 10.1093/brain/awac299  0.344
2022 Hansson O, Edelmayer RM, Boxer AL, Carrillo MC, Mielke MM, Rabinovici GD, Salloway S, Sperling R, Zetterberg H, Teunissen CE. The Alzheimer's Association appropriate use recommendations for blood biomarkers in Alzheimer's disease. Alzheimer's & Dementia : the Journal of the Alzheimer's Association. PMID 35908251 DOI: 10.1002/alz.12756  0.329
2022 Strikwerda-Brown C, Hobbs DA, Gonneaud J, St-Onge F, Binette AP, Ozlen H, Provost K, Soucy JP, Buckley RF, Benzinger TLS, Morris JC, Villemagne VL, Doré V, Sperling RA, Johnson KA, et al. Association of Elevated Amyloid and Tau Positron Emission Tomography Signal With Near-Term Development of Alzheimer Disease Symptoms in Older Adults Without Cognitive Impairment. Jama Neurology. PMID 35907254 DOI: 10.1001/jamaneurol.2022.2379  0.375
2022 Yau WW, Shirzadi Z, Yang HS, Ikoba AP, Rabin JS, Properzi MJ, Kirn DR, Schultz AP, Rentz DM, Johnson KA, Sperling RA, Chhatwal JP. Tau mediates synergistic influence of vascular risk and Aβ on cognitive decline. Annals of Neurology. PMID 35880989 DOI: 10.1002/ana.26460  0.317
2022 Sepulveda-Falla D, Sanchez JS, Almeida MC, Boassa D, Acosta-Uribe J, Vila-Castelar C, Ramirez-Gomez L, Baena A, Aguillon D, Villalba-Moreno ND, Littau JL, Villegas A, Beach TG, White CL, Ellisman M, ... ... Sperling RA, et al. Distinct tau neuropathology and cellular profiles of an APOE3 Christchurch homozygote protected against autosomal dominant Alzheimer's dementia. Acta Neuropathologica. PMID 35838824 DOI: 10.1007/s00401-022-02467-8  0.321
2022 Assunção SS, Sperling RA, Ritchie C, Kerwin DR, Aisen PS, Lansdall C, Atri A, Cummings J. Meaningful benefits: a framework to assess disease-modifying therapies in preclinical and early Alzheimer's disease. Alzheimer's Research & Therapy. 14: 54. PMID 35440022 DOI: 10.1186/s13195-022-00984-y  0.341
2022 Young CB, Winer JR, Younes K, Cody KA, Betthauser TJ, Johnson SC, Schultz A, Sperling RA, Greicius MD, Cobos I, Poston KL, Mormino EC. Divergent Cortical Tau Positron Emission Tomography Patterns Among Patients With Preclinical Alzheimer Disease. Jama Neurology. PMID 35435938 DOI: 10.1001/jamaneurol.2022.0676  0.329
2022 Guzmán-Vélez E, Diez I, Schoemaker D, Pardilla-Delgado E, Vila-Castelar C, Fox-Fuller JT, Baena A, Sperling RA, Johnson KA, Lopera F, Sepulcre J, Quiroz YT. Amyloid-β and tau pathologies relate to distinctive brain dysconnectomics in preclinical autosomal-dominant Alzheimer's disease. Proceedings of the National Academy of Sciences of the United States of America. 119: e2113641119. PMID 35380901 DOI: 10.1073/pnas.2113641119  0.417
2022 Farrell ME, Papp KV, Buckley RF, Jacobs HIL, Schultz AP, Properzi MJ, Vannini P, Hanseeuw BJ, Rentz DM, Johnson KA, Sperling RA. Association of Emerging β-Amyloid and Tau Pathology With Early Cognitive Changes in Clinically Normal Older Adults. Neurology. PMID 35338074 DOI: 10.1212/WNL.0000000000200137  0.349
2022 Prokopiou PC, Engels-Domínguez N, Papp KV, Scott MR, Schultz AP, Schneider C, Farrell ME, Buckley RF, Quiroz YT, El Fakhri G, Rentz DM, Sperling RA, Johnson KA, Jacobs HIL. Lower novelty-related locus coeruleus function is associated with Aβ-related cognitive decline in clinically healthy individuals. Nature Communications. 13: 1571. PMID 35322012 DOI: 10.1038/s41467-022-28986-2  0.359
2022 Jacobs HIL, Becker JA, Kwong K, Munera D, Ramirez-Gomez L, Engels-Domínguez N, Sanchez JS, Vila-Castelar C, Baena A, Sperling RA, Johnson KA, Lopera F, Quiroz YT. Waning locus coeruleus integrity precedes cortical tau accrual in preclinical autosomal dominant Alzheimer's disease. Alzheimer's & Dementia : the Journal of the Alzheimer's Association. PMID 35298083 DOI: 10.1002/alz.12656  0.374
2022 Jacobs HIL, O'Donnell A, Satizabal CL, Lois C, Kojis D, Hanseeuw BJ, Thibault E, Sanchez JS, Buckley RF, Yang Q, DeCarli C, Killiany R, Sargurupremraj M, Sperling RA, Johnson KA, et al. Associations Between Brainstem Volume and Alzheimer's Disease Pathology in Middle-Aged Individuals of the Framingham Heart Study. Journal of Alzheimer's Disease : Jad. PMID 35213372 DOI: 10.3233/JAD-215372  0.345
2022 Munro CE, Buckley R, Vannini P, DeMuro C, Sperling R, Rentz DM, Johnson K, Gatchel JR, Amariglio R. Longitudinal Trajectories of Participant- and Study Partner-Rated Cognitive Decline, in Relation to Alzheimer's Disease Biomarkers and Mood Symptoms. Frontiers in Aging Neuroscience. 13: 806432. PMID 35173601 DOI: 10.3389/fnagi.2021.806432  0.313
2022 Petersen KK, Grober E, Lipton RB, Sperling RA, Buckley RF, Aisen PS, Ezzati A. Impact of sex and ε4 on the association of cognition and hippocampal volume in clinically normal, amyloid positive adults. Alzheimer's & Dementia (Amsterdam, Netherlands). 14: e12271. PMID 35155730 DOI: 10.1002/dad2.12271  0.316
2021 Grober E, Papp KV, Rentz DM, Sperling RA, Johnson KA, Amariglio RE, Schultz A, Lipton RB, Ezzati A. Neuroimaging correlates of Stages of Objective Memory Impairment (SOMI) system. Alzheimer's & Dementia (Amsterdam, Netherlands). 13: e12224. PMID 35005192 DOI: 10.1002/dad2.12224  0.329
2021 Papp KV, Samaroo A, Chou HC, Buckley R, Schneider OR, Hsieh S, Soberanes D, Quiroz Y, Properzi M, Schultz A, García-Magariño I, Marshall GA, Burke JG, Kumar R, Snyder N, ... ... Sperling RA, et al. Unsupervised mobile cognitive testing for use in preclinical Alzheimer's disease. Alzheimer's & Dementia (Amsterdam, Netherlands). 13: e12243. PMID 34621977 DOI: 10.1002/dad2.12243  0.318
2021 Rodriguez-Vieitez E, Montal V, Sepulcre J, Lois C, Hanseeuw B, Vilaplana E, Schultz AP, Properzi MJ, Scott MR, Amariglio R, Papp KV, Marshall GA, Fortea J, Johnson KA, Sperling RA, et al. Association of cortical microstructure with amyloid-β and tau: impact on cognitive decline, neurodegeneration, and clinical progression in older adults. Molecular Psychiatry. PMID 34588623 DOI: 10.1038/s41380-021-01290-z  0.352
2021 Jacobs HIL, Becker JA, Kwong K, Engels-Domínguez N, Prokopiou PC, Papp KV, Properzi M, Hampton OL, d'Oleire Uquillas F, Sanchez JS, Rentz DM, El Fakhri G, Normandin MD, Price JC, Bennett DA, Sperling RA, et al. In vivo and neuropathology data support locus coeruleus integrity as indicator of Alzheimer's disease pathology and cognitive decline. Science Translational Medicine. 13: eabj2511. PMID 34550726 DOI: 10.1126/scitranslmed.abj2511  0.764
2021 McDade E, Voytyuk I, Aisen P, Bateman RJ, Carrillo MC, De Strooper B, Haass C, Reiman EM, Sperling R, Tariot PN, Yan R, Masters CL, Vassar R, Lichtenthaler SF. The case for low-level BACE1 inhibition for the prevention of Alzheimer disease. Nature Reviews. Neurology. PMID 34548654 DOI: 10.1038/s41582-021-00545-1  0.302
2021 Fox-Fuller JT, Torrico-Teave H, d'Oleire Uquillas F, Chen K, Su Y, Chen Y, Brickhouse M, Sanchez JS, Aguero C, Jacobs HIL, Hampton O, Guzmán-Vélez E, Vila-Castelar C, Aguirre-Acevedo DC, Baena A, ... ... Sperling RA, et al. Cortical thickness across the lifespan in a Colombian cohort with autosomal-dominant Alzheimer's disease: A cross-sectional study. Alzheimer's & Dementia (Amsterdam, Netherlands). 13: e12233. PMID 34541287 DOI: 10.1002/dad2.12233  0.801
2021 Ngolab J, Donohue M, Belsha A, Salazar J, Cohen P, Jaiswal S, Tan V, Gessert D, Korouri S, Aggarwal NT, Alber J, Johnson K, Jicha G, van Dyck C, Lah J, ... Sperling RA, et al. Feasibility study for detection of retinal amyloid in clinical trials: The Anti-Amyloid Treatment in Asymptomatic Alzheimer's Disease (A4) trial. Alzheimer's & Dementia (Amsterdam, Netherlands). 13: e12199. PMID 34430703 DOI: 10.1002/dad2.12199  0.303
2021 Belloy ME, Eger SJ, Le Guen Y, Napolioni V, Deters KD, Yang HS, Scelsi MA, Porter T, James SN, Wong A, Schott JM, Sperling RA, Laws SM, Mormino EC, He Z, et al. KL∗VS heterozygosity reduces brain amyloid in asymptomatic at-risk APOE∗4 carriers. Neurobiology of Aging. 101: 123-129. PMID 33610961 DOI: 10.1016/j.neurobiolaging.2021.01.008  0.338
2021 Guzmán-Vélez E, Zetterberg H, Fox-Fuller JT, Vila-Castelar C, Sanchez JS, Baena A, Garcia-Ospina G, Aguillon D, Pardilla-Delgado E, Gatchel JR, Sperling RA, Johnson K, Reiman EM, Blennow K, Lopera F, et al. Associations between plasma neurofilament light, in vivo brain pathology, and cognition in non-demented individuals with autosomal-dominant Alzheimer's disease. Alzheimer's & Dementia : the Journal of the Alzheimer's Association. PMID 33527648 DOI: 10.1002/alz.12248  0.324
2021 Sanchez JS, Becker JA, Jacobs HIL, Hanseeuw BJ, Jiang S, Schultz AP, Properzi MJ, Katz SR, Beiser A, Satizabal CL, O'Donnell A, DeCarli C, Killiany R, El Fakhri G, Normandin MD, ... Sperling RA, et al. The cortical origin and initial spread of medial temporal tauopathy in Alzheimer's disease assessed with positron emission tomography. Science Translational Medicine. 13. PMID 33472953 DOI: 10.1126/scitranslmed.abc0655  0.376
2021 Sanchez JS, Hanseeuw BJ, Lopera F, Sperling RA, Baena A, Bocanegra Y, Aguillon D, Guzmán-Vélez E, Pardilla-Delgado E, Ramirez-Gomez L, Vila-Castelar C, Martinez JE, Fox-Fuller JT, Ramos C, Ochoa-Escudero M, et al. Longitudinal amyloid and tau accumulation in autosomal dominant Alzheimer's disease: findings from the Colombia-Boston (COLBOS) biomarker study. Alzheimer's Research & Therapy. 13: 27. PMID 33451357 DOI: 10.1186/s13195-020-00765-5  0.334
2020 Samaroo A, Amariglio RE, Burnham S, Sparks P, Properzi M, Schultz AP, Buckley R, Johnson KA, Sperling RA, Rentz DM, Papp KV. Diminished Learning Over Repeated Exposures (LORE) in preclinical Alzheimer's disease. Alzheimer's & Dementia (Amsterdam, Netherlands). 12: e12132. PMID 33426266 DOI: 10.1002/dad2.12132  0.324
2020 Chhatwal JP, Schultz AP, Dang Y, Ostaszewski B, Liu L, Yang HS, Johnson KA, Sperling RA, Selkoe DJ. Plasma N-terminal tau fragment levels predict future cognitive decline and neurodegeneration in healthy elderly individuals. Nature Communications. 11: 6024. PMID 33247134 DOI: 10.1038/s41467-020-19543-w  0.525
2020 Dubbelman MA, Jutten RJ, Tomaszewski Farias SE, Amariglio RE, Buckley RF, Visser PJ, Rentz DM, Johnson KA, Properzi MJ, Schultz A, Donovan N, Gatchell JR, Teunissen CE, Van Berckel BNM, Van der Flier WM, Sperling RA, et al. Decline in cognitively complex everyday activities accelerates along the Alzheimer's disease continuum. Alzheimer's Research & Therapy. 12: 138. PMID 33121534 DOI: 10.1186/s13195-020-00706-2  0.377
2020 Jutten RJ, Sikkes SAM, Amariglio RE, Buckley RF, Properzi MJ, Marshall GA, Rentz DM, Johnson KA, Teunissen CE, Van Berckel BNM, Van der Flier WM, Scheltens P, Sperling RA, Papp KV, et al. Identifying Sensitive Measures of Cognitive Decline at Different Clinical Stages of Alzheimer's Disease. Journal of the International Neuropsychological Society : Jins. 1-13. PMID 33046162 DOI: 10.1017/S1355617720000934  0.348
2020 Hampton OL, Buckley RF, Manning LK, Scott MR, Properzi MJ, Peña-Gómez C, Jacobs HIL, Chhatwal JP, Johnson KA, Sperling RA, Schultz AP. Resting-state functional connectivity and amyloid burden influence longitudinal cortical thinning in the default mode network in preclinical Alzheimer's disease. Neuroimage. Clinical. 28: 102407. PMID 32942175 DOI: 10.1016/J.Nicl.2020.102407  0.346
2020 Walter S, Langford OG, Clanton TB, Jimenez-Maggiora GA, Raman R, Rafii MS, Shaffer EJ, Sperling RA, Cummings JL, Aisen PS. The Trial-Ready Cohort for Preclinical and Prodromal Alzheimer's Disease (TRC-PAD): Experience from the First 3 Years. The Journal of Prevention of Alzheimer's Disease. 7: 234-241. PMID 32920625 DOI: 10.14283/jpad.2020.47  0.315
2020 Vila-Castelar C, Muñoz N, Papp KV, Amariglio RE, Baena A, Guzmán-Vélez E, Bocanegra Y, Sanchez JS, Reiman EM, Johnson KA, Sperling RA, Lopera F, Rentz DM, Quiroz YT. The Latin American Spanish version of the Face-Name Associative Memory Exam is sensitive to cognitive and pathological changes in preclinical autosomal dominant Alzheimer's disease. Alzheimer's Research & Therapy. 12: 104. PMID 32912283 DOI: 10.1186/s13195-020-00671-w  0.463
2020 Norton DJ, Parra MA, Sperling RA, Baena A, Guzman-Velez E, Jin DS, Andrea N, Khang J, Schultz A, Rentz DM, Pardilla-Delgado E, Fuller J, Johnson K, Reiman EM, Lopera F, et al. Visual short-term memory relates to tau and amyloid burdens in preclinical autosomal dominant Alzheimer's disease. Alzheimer's Research & Therapy. 12: 99. PMID 32825838 DOI: 10.1186/S13195-020-00660-Z  0.322
2020 Grill JD, Raman R, Ernstrom K, Sultzer DL, Burns JM, Donohue MC, Johnson KA, Aisen PS, Sperling RA, Karlawish J. Short-term Psychological Outcomes of Disclosing Amyloid Imaging Results to Research Participants Who Do Not Have Cognitive Impairment. Jama Neurology. PMID 32777010 DOI: 10.1001/Jamaneurol.2020.2734  0.321
2020 Guzmán-Vélez E, Martínez J, Papp K, Baena A, Vila-Castelar C, Artola A, Schultz AP, Bocanegra Y, Sanchez J, Rentz D, Tariot PN, Reiman EM, Sperling R, Johnson KA, Lopera F, et al. Associative memory and in vivo brain pathology in asymptomatic presenilin-1 E280A carriers. Neurology. PMID 32611637 DOI: 10.1212/Wnl.0000000000010177  0.411
2020 Raghavan NS, Dumitrescu L, Mormino E, Mahoney ER, Lee AJ, Gao Y, Bilgel M, Goldstein D, Harrison T, Engelman CD, Saykin AJ, Whelan CD, Liu JZ, Jagust W, Albert M, ... ... Sperling R, et al. Association Between Common Variants in RBFOX1, an RNA-Binding Protein, and Brain Amyloidosis in Early and Preclinical Alzheimer Disease. Jama Neurology. PMID 32568366 DOI: 10.1001/Jamaneurol.2020.1760  0.508
2020 Schultz SA, Strain JF, Adedokun A, Wang Q, Preische O, Kuhle J, Flores S, Keefe S, Dincer A, Ances BM, Berman SB, Brickman AM, Cash DM, Chhatwal J, Cruchaga C, ... ... Sperling R, et al. Serum neurofilament light chain levels are associated with white matter integrity in autosomal dominant Alzheimer's disease. Neurobiology of Disease. 104960. PMID 32522711 DOI: 10.1016/J.Nbd.2020.104960  0.301
2020 Scott MR, Hampton OL, Buckley RF, Chhatwal JP, Hanseeuw BJ, Jacobs HIL, Properzi MJ, Sanchez JS, Johnson KA, Sperling RA, Schultz AP. Inferior temporal tau is associated with accelerated prospective cortical thinning in clinically normal older adults. Neuroimage. 116991. PMID 32512123 DOI: 10.1016/J.Neuroimage.2020.116991  0.359
2020 Aisen PS, Cummings J, Doody R, Kramer L, Salloway S, Selkoe DJ, Sims J, Sperling RA, Vellas B. The Future of Anti-Amyloid Trials. The Journal of Prevention of Alzheimer's Disease. 7: 146-151. PMID 32463066 DOI: 10.14283/jpad.2020.24  0.476
2020 Insel PS, Donohue MC, Sperling R, Hansson O, Mattsson-Carlgren N. The A4 study: β-amyloid and cognition in 4432 cognitively unimpaired adults. Annals of Clinical and Translational Neurology. PMID 32315118 DOI: 10.1002/Acn3.51048  0.394
2020 Jacobs HIL, Augustinack JC, Schultz AP, Hanseeuw BJ, Locascio J, Amariglio RE, Papp KV, Rentz DM, Sperling RA, Johnson KA. The presubiculum links incipient amyloid and tau pathology to memory function in older persons. Neurology. PMID 32273431 DOI: 10.1212/WNL.0000000000009362  0.398
2020 Rabin JS, Shirzadi Z, Swardfager W, MacIntosh BJ, Schultz A, Yang HS, Buckley RF, Gatchel JR, Kirn D, Pruzin JJ, Hedden T, Lipsman N, Rentz DM, Black SE, Johnson KA, Sperling RA, et al. Amyloid-beta burden predicts prospective decline in body mass index in clinically normal adults. Neurobiology of Aging. PMID 32249013 DOI: 10.1016/J.Neurobiolaging.2020.03.002  0.32
2020 Biddle KD, Jacobs HIL, d'Oleire Uquillas F, Zide BS, Kirn DR, Properzi MR, Rentz DM, Johnson KA, Sperling RA, Donovan NJ. Associations of Widowhood and β-Amyloid With Cognitive Decline in Cognitively Unimpaired Older Adults. Jama Network Open. 3: e200121. PMID 32101313 DOI: 10.1001/jamanetworkopen.2020.0121  0.763
2020 Putcha D, Dickerson BC, Brickhouse M, Johnson KA, Sperling RA, Papp KV. Word retrieval across the biomarker-confirmed Alzheimer's disease syndromic spectrum. Neuropsychologia. 107391. PMID 32057937 DOI: 10.1016/j.neuropsychologia.2020.107391  0.588
2020 Davidow J, Biddle K, Johnson K, Sperling R, Donovan N. INTERACTIVE ASSOCIATION OF LIVING ALONE AND AMYLOID-Β BURDEN WITH LONGITUDINAL COGNITION IN COGNITIVELY UNIMPAIRED OLDER ADULTS The American Journal of Geriatric Psychiatry. 28: S76. DOI: 10.1016/J.Jagp.2020.01.102  0.43
2019 Gatchel JR, Lopera F, Norton DJ, Baena A, Guzman-Velez E, Sanchez JS, d'Oleire Uquillas F, Schultz A, Vannini P, Artola A, Amariglio RE, Rentz DM, Tariot PN, Reiman EM, Johnson KA, Sperling RA, et al. Association of subjective cognitive decline with markers of brain pathology in preclinical autosomal dominant Alzheimer's disease. Journal of Neurology, Neurosurgery, and Psychiatry. PMID 31874859 DOI: 10.1136/Jnnp-2019-321205  0.798
2019 Greenberg SM, Bacskai BJ, Hernandez-Guillamon M, Pruzin J, Sperling R, van Veluw SJ. Cerebral amyloid angiopathy and Alzheimer disease - one peptide, two pathways. Nature Reviews. Neurology. PMID 31827267 DOI: 10.1038/S41582-019-0281-2  0.429
2019 Jack CR, Holtzman DM, Sperling R. Dementia is not synonymous with Alzheimer's disease. Science Translational Medicine. 11. PMID 31826979 DOI: 10.1126/Scitranslmed.Aav0511  0.419
2019 Vannini P, Uquillas FD, Jacobs HIL, Sepulcre J, Gatchel J, Amariglio RE, Hanseeuw B, Papp KV, Hedden T, Rentz DM, Pascual-Leone A, Johnson KA, Sperling RA. Decreased meta-memory is associated with early tauopathy in cognitively unimpaired older adults. Neuroimage. Clinical. 24: 102097. PMID 31795044 DOI: 10.1016/J.Nicl.2019.102097  0.379
2019 Papp KV, Buckley R, Mormino E, Maruff P, Villemagne VL, Masters CL, Johnson KA, Rentz DM, Sperling RA, Amariglio RE. Clinical meaningfulness of subtle cognitive decline on longitudinal testing in preclinical AD. Alzheimer's & Dementia : the Journal of the Alzheimer's Association. PMID 31759879 DOI: 10.1016/J.Jalz.2019.09.074  0.345
2019 Schultz AP, Buckley RF, Hampton OL, Scott MR, Properzi MJ, Peña-Gómez C, Pruzin JJ, Yang HS, Johnson KA, Sperling RA, Chhatwal JP. Longitudinal degradation of the default/salience network axis in symptomatic individuals with elevated amyloid burden. Neuroimage. Clinical. 102052. PMID 31711955 DOI: 10.1016/J.Nicl.2019.102052  0.308
2019 d'Oleire Uquillas F, Jacobs HIL, Schultz AP, Hanseeuw BJ, Buckley RF, Sepulcre J, Pascual-Leone A, Donovan NJ, Johnson KA, Sperling RA, Vannini P. Functional and Pathological Correlates of Judgments of Learning in Cognitively Unimpaired Older Adults. Cerebral Cortex (New York, N.Y. : 1991). PMID 31696223 DOI: 10.1093/cercor/bhz217  0.792
2019 Arboleda-Velasquez JF, Lopera F, O'Hare M, Delgado-Tirado S, Marino C, Chmielewska N, Saez-Torres KL, Amarnani D, Schultz AP, Sperling RA, Leyton-Cifuentes D, Chen K, Baena A, Aguillon D, Rios-Romenets S, et al. Resistance to autosomal dominant Alzheimer's disease in an APOE3 Christchurch homozygote: a case report. Nature Medicine. PMID 31686034 DOI: 10.1038/S41591-019-0611-3  0.322
2019 Schultz A, Kloet RW, Sohrabi HR, van der Weerd L, van Rooden S, Wermer MJH, Grand Moursel L, Yaqub M, van Berckel BNM, Chatterjee P, Gardener SL, Taddei K, Fagan AM, Benzinger TL, Morris JC, ... Sperling R, et al. Amyloid Imaging of Dutch-type Hereditary Cerebral Amyloid Angiopathy Carriers. Annals of Neurology. PMID 31361916 DOI: 10.1002/Ana.25560  0.326
2019 Rabin JS, Klein H, Kirn DR, Schultz AP, Yang HS, Hampton O, Jiang S, Buckley RF, Viswanathan A, Hedden T, Pruzin J, Yau WW, Guzmán-Vélez E, Quiroz YT, Properzi M, ... Sperling RA, et al. Associations of Physical Activity and β-Amyloid With Longitudinal Cognition and Neurodegeneration in Clinically Normal Older Adults. Jama Neurology. PMID 31312836 DOI: 10.1001/Jamaneurol.2019.1879  0.32
2019 Rabin JS, Perea RD, Buckley RF, Johnson KA, Sperling RA, Hedden T. Synergism between fornix microstructure and beta amyloid accelerates memory decline in clinically normal older adults. Neurobiology of Aging. 81: 38-46. PMID 31207468 DOI: 10.1016/j.neurobiolaging.2019.05.005  0.371
2019 Daiello LA, Racine AM, Yun Gou R, Marcantonio ER, Xie Z, Kunze LJ, Vlassakov KV, Inouye SK, Jones RN, Alsop D, Travison T, Arnold S, Cooper Z, Dickerson B, Fong T, ... ... Sperling R, et al. Postoperative Delirium and Postoperative Cognitive Dysfunction: Overlap and Divergence. Anesthesiology. PMID 31166241 DOI: 10.1097/Aln.0000000000002729  0.517
2019 Hanseeuw BJ, Betensky RA, Jacobs HIL, Schultz AP, Sepulcre J, Becker JA, Cosio DMO, Farrell M, Quiroz YT, Mormino EC, Buckley RF, Papp KV, Amariglio RA, Dewachter I, Ivanoiu A, ... Sperling RA, et al. Association of Amyloid and Tau With Cognition in Preclinical Alzheimer Disease: A Longitudinal Study. Jama Neurology. PMID 31157827 DOI: 10.1001/Jamaneurol.2019.1424  0.718
2019 Nelson PT, Dickson DW, Trojanowski JQ, Jack CR, Boyle PA, Arfanakis K, Rademakers R, Alafuzoff I, Attems J, Brayne C, Coyle-Gilchrist ITS, Chui HC, Fardo DW, Flanagan ME, Halliday G, ... Sperling RA, et al. Limbic-predominant age-related TDP-43 encephalopathy (LATE): consensus working group report. Brain : a Journal of Neurology. PMID 31039256 DOI: 10.1093/Brain/Awz099  0.345
2019 Henley D, Raghavan N, Sperling R, Aisen P, Raman R, Romano G. Preliminary Results of a Trial of Atabecestat in Preclinical Alzheimer's Disease. The New England Journal of Medicine. 380: 1483-1485. PMID 30970197 DOI: 10.1056/Nejmc1813435  0.401
2019 Fuller JT, Cronin-Golomb A, Gatchel JR, Norton DJ, Guzmán-Vélez E, Jacobs HIL, Hanseeuw B, Pardilla-Delgado E, Artola A, Baena A, Bocanegra Y, Kosik KS, Chen K, Tariot PN, Johnson K, Sperling RA, et al. Biological and Cognitive Markers of Presenilin1 E280A Autosomal Dominant Alzheimer's Disease: A Comprehensive Review of the Colombian Kindred. The Journal of Prevention of Alzheimer's Disease. 6: 112-120. PMID 30756118 DOI: 10.14283/jpad.2019.6  0.345
2019 Hanseeuw BJ, Lopera F, Sperling RA, Norton DJ, Guzman-Velez E, Baena A, Pardilla-Delgado E, Schultz AP, Gatchel J, Jin D, Chen K, Reiman EM, Johnson KA, Quiroz YT. Striatal amyloid is associated with tauopathy and memory decline in familial Alzheimer's disease. Alzheimer's Research & Therapy. 11: 17. PMID 30717814 DOI: 10.1186/S13195-019-0468-1  0.338
2019 Halawa OA, Gatchel JR, Amariglio RE, Rentz DM, Sperling RA, Johnson KA, Marshall GA. Inferior and medial temporal tau and cortical amyloid are associated with daily functional impairment in Alzheimer's disease. Alzheimer's Research & Therapy. 11: 14. PMID 30704519 DOI: 10.1186/s13195-019-0471-6  0.412
2019 Tan CH, Bonham LW, Fan CC, Mormino EC, Sugrue LP, Broce IJ, Hess CP, Yokoyama JS, Rabinovici GD, Miller BL, Yaffe K, Schellenberg GD, Kauppi K, Holland D, McEvoy LK, ... Sperling RA, et al. Polygenic hazard score, amyloid deposition and Alzheimer's neurodegeneration. Brain : a Journal of Neurology. PMID 30689776 DOI: 10.1093/Brain/Awy327  0.368
2019 Marshall GA, Gatchel JR, Donovan NJ, Muniz MC, Schultz AP, Becker JA, Chhatwal JP, Hanseeuw BJ, Papp KV, Amariglio RE, Rentz DM, Sperling RA, Johnson KA. Regional Tau Correlates of Instrumental Activities of Daily Living and Apathy in Mild Cognitive Impairment and Alzheimer's Disease Dementia. Journal of Alzheimer's Disease : Jad. 67: 757-768. PMID 30689584 DOI: 10.3233/Jad-170578  0.385
2019 Jagust W, Jack CR, Bennett DA, Blennow K, Haeberlein SB, Holtzman DM, Jessen F, Karlawish J, Liu E, Molinuevo JL, Montine T, Phelps C, Rankin KP, Rowe CC, Scheltens P, ... Sperling R, et al. "Alzheimer's disease" is neither "Alzheimer's clinical syndrome" nor "dementia". Alzheimer's & Dementia : the Journal of the Alzheimer's Association. 15: 153-157. PMID 30642435 DOI: 10.1016/J.Jalz.2018.11.002  0.413
2019 Yang H, Ge T, Finucane H, De Jager PL, Sperling RA. P4-496: MYELOID CELL-SPECIFIC ALZHEIMER'S DISEASE POLYGENIC RISK SCORE PREDICTS NEURODEGENERATION AND Aβ-RELATED COGNITIVE DECLINE IN COGNITIVELY NORMAL OLDER ADULTS Alzheimer's & Dementia. 15: P1503-P1504. DOI: 10.1016/j.jalz.2019.08.042  0.322
2019 Ying Lim YY, Sperling RA, Insel P, Maruff P, Johnson KA, Mormino EC. DISTINCT CONTRIBUTIONS OF BASELINE AND LONGITUDINAL AMYLOID PET MEASURES TO MEMORY DECLINE IN COGNITIVELY NORMAL OLDER ADULTS Alzheimer's & Dementia. 15: P179-P180. DOI: 10.1016/j.jalz.2019.06.4379  0.312
2019 Jacobs HI, Becker A, Sperling RA, Guzman-Velez E, Baena A, Uquillas Fd, Artola A, Pardilla-Delgado E, Gatchel JR, Reiman EM, Johnson KA, Lopera F, Quiroz YT. P2-425: LOCUS COERULEUS INTENSITY IS ASSOCIATED WITH EARLY AMYLOID AND TAU PATHOLOGY IN PRECLINICAL AUTOSOMAL DOMINANT ALZHEIMER'S DISEASE Alzheimer's & Dementia. 15: P774-P775. DOI: 10.1016/J.Jalz.2019.06.2832  0.304
2018 Vöglein J, Noachtar S, McDade E, Quaid KA, Salloway S, Ghetti B, Noble J, Berman S, Chhatwal J, Mori H, Fox N, Allegri R, Masters CL, Buckles V, Ringman JM, ... ... Sperling R, et al. Seizures as an early symptom of autosomal dominant Alzheimer's disease. Neurobiology of Aging. 76: 18-23. PMID 30616208 DOI: 10.1016/J.Neurobiolaging.2018.11.022  0.305
2018 Rabin JS, Yang HS, Schultz AP, Hanseeuw BJ, Hedden T, Viswanathan A, Gatchel JR, Marshall GA, Kilpatrick E, Klein H, Rao V, Buckley RF, Yau WW, Kirn DR, Rentz DM, ... Sperling RA, et al. Vascular risk and β-amyloid are synergistically associated with cortical tau. Annals of Neurology. PMID 30565287 DOI: 10.1002/Ana.25399  0.326
2018 d'Oleire Uquillas F, Jacobs HIL, Biddle KD, Properzi M, Hanseeuw B, Schultz AP, Rentz DM, Johnson KA, Sperling RA, Donovan NJ. Regional tau pathology and loneliness in cognitively normal older adults. Translational Psychiatry. 8: 282. PMID 30563962 DOI: 10.1038/s41398-018-0345-x  0.795
2018 Sperling RA, Mormino EC, Schultz AP, Betensky RA, Papp KV, Amariglio RE, Hanseeuw BJ, Buckley R, Chhatwal J, Hedden T, Marshall GA, Quiroz YT, Donovan NJ, Jackson J, Gatchel JR, et al. The impact of Aβ and tau on prospective cognitive decline in older individuals. Annals of Neurology. PMID 30549303 DOI: 10.1002/Ana.25395  0.382
2018 Huijbers W, Schultz AP, Papp KV, LaPoint MR, Hanseeuw B, Chhatwal JP, Hedden T, Johnson KA, Sperling RA. Tau accumulation in clinically normal older adults is associated with hippocampal hyperactivity. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. PMID 30482786 DOI: 10.1523/Jneurosci.1397-18.2018  0.731
2018 Chen Z, Mengel D, Keshavan A, Rissman RA, Billinton A, Perkinton M, Percival-Alwyn J, Schultz A, Properzi M, Johnson K, Selkoe DJ, Sperling RA, Patel P, Zetterberg H, Galasko D, et al. Learnings about the complexity of extracellular tau aid development of a blood-based screen for Alzheimer's disease. Alzheimer's & Dementia : the Journal of the Alzheimer's Association. PMID 30419228 DOI: 10.1016/J.Jalz.2018.09.010  0.473
2018 Brashear HR, Ketter N, Bogert J, Di J, Salloway SP, Sperling R. Clinical Evaluation of Amyloid-Related Imaging Abnormalities in Bapineuzumab Phase III Studies. Journal of Alzheimer's Disease : Jad. PMID 30412493 DOI: 10.3233/Jad-180675  0.359
2018 Sepulcre J, Grothe MJ, d'Oleire Uquillas F, Ortiz-Terán L, Diez I, Yang HS, Jacobs HIL, Hanseeuw BJ, Li Q, El-Fakhri G, Sperling RA, Johnson KA. Neurogenetic contributions to amyloid beta and tau spreading in the human cortex. Nature Medicine. PMID 30374196 DOI: 10.1038/S41591-018-0206-4  0.758
2018 Müller S, Preische O, Sohrabi HR, Gräber S, Jucker M, Ringman JM, Martins RN, McDade E, Schofield PR, Ghetti B, Rossor M, Fox NN, Graff-Radford NR, Levin J, Danek A, ... ... Sperling R, et al. Relationship between physical activity, cognition, and Alzheimer pathology in autosomal dominant Alzheimer's disease. Alzheimer's & Dementia : the Journal of the Alzheimer's Association. PMID 30266303 DOI: 10.1016/J.Jalz.2018.06.3059  0.447
2018 McDade E, Wang G, Gordon BA, Hassenstab J, Benzinger TLS, Buckles V, Fagan AM, Holtzman DM, Cairns NJ, Goate AM, Marcus DS, Morris JC, Paumier K, Xiong C, Allegri R, ... Sperling RA, et al. Longitudinal cognitive and biomarker changes in dominantly inherited Alzheimer disease. Neurology. PMID 30217935 DOI: 10.1212/Wnl.0000000000006277  0.335
2018 Guzmán-Vélez E, Jaimes S, Aguirre-Acevedo DC, Norton DJ, Papp KV, Amariglio R, Rentz D, Baena A, Henao E, Tirado V, Muñoz C, Giraldo M, Sperling RA, Lopera F, Quiroz YT. A Three-Factor Structure of Cognitive Functioning Among Carriers and Non-Carriers of Autosomal-Dominant Alzheimer's Disease. Journal of Alzheimer's Disease : Jad. PMID 30040714 DOI: 10.1093/Arclin/Acw043.34  0.327
2018 Salloway SP, Sperling R, Fox NC, Sabbagh MN, Honig LS, Porsteinsson AP, Rofael H, Ketter N, Wang D, Liu E, Carr S, Black RS, Brashear HR. Long-Term Follow Up of Patients with Mild-to-Moderate Alzheimer's Disease Treated with Bapineuzumab in a Phase III, Open-Label, Extension Study. Journal of Alzheimer's Disease : Jad. PMID 29914022 DOI: 10.3233/Jad-171157  0.369
2018 Munro CE, Donovan NJ, Amariglio RE, Papp KV, Marshall GA, Rentz DM, Pascual-Leone A, Sperling RA, Locascio JJ, Vannini P. The Impact of Awareness of and Concern About Memory Performance on the Prediction of Progression From Mild Cognitive Impairment to Alzheimer Disease Dementia. The American Journal of Geriatric Psychiatry : Official Journal of the American Association For Geriatric Psychiatry. PMID 29866588 DOI: 10.1016/j.jagp.2018.04.008  0.399
2018 Buckley RF, Mormino EC, Amariglio RE, Properzi MJ, Rabin JS, Lim YY, Papp KV, Jacobs HIL, Burnham S, Hanseeuw BJ, Doré V, Dobson A, Masters CL, Waller M, Rowe CC, ... Sperling RA, et al. Sex, amyloid, and APOE ε4 and risk of cognitive decline in preclinical Alzheimer's disease: Findings from three well-characterized cohorts. Alzheimer's & Dementia : the Journal of the Alzheimer's Association. PMID 29803541 DOI: 10.1016/J.Jalz.2018.04.010  0.314
2018 Rabin JS, Schultz AP, Hedden T, Viswanathan A, Marshall GA, Kilpatrick E, Klein H, Buckley RF, Yang HS, Properzi M, Rao V, Kirn DR, Papp KV, Rentz DM, Johnson KA, Sperling RA, et al. Interactive Associations of Vascular Risk and β-Amyloid Burden With Cognitive Decline in Clinically Normal Elderly Individuals: Findings From the Harvard Aging Brain Study. Jama Neurology. PMID 29799986 DOI: 10.1001/Jamaneurol.2018.1123  0.317
2018 Orlovsky I, Huijbers W, Hanseeuw BJ, Mormino EC, Hedden T, Buckley RF, LaPoint M, Rabin JS, Rentz DM, Johnson KA, Sperling RA, Papp KV. The relationship between recall of recently versus remotely encoded famous faces and amyloidosis in clinically normal older adults. Alzheimer's & Dementia (Amsterdam, Netherlands). 10: 121-129. PMID 29780861 DOI: 10.1016/J.Dadm.2017.11.003  0.722
2018 Jack CR, Bennett DA, Blennow K, Carrillo MC, Dunn B, Haeberlein SB, Holtzman DM, Jagust W, Jessen F, Karlawish J, Liu E, Molinuevo JL, Montine T, Phelps C, Rankin KP, ... Sperling R, et al. NIA-AA Research Framework: Toward a biological definition of Alzheimer's disease. Alzheimer's & Dementia : the Journal of the Alzheimer's Association. 14: 535-562. PMID 29653606 DOI: 10.1016/J.Jalz.2018.02.018  0.466
2018 Ge T, Sabuncu MR, Smoller JW, Sperling RA, Mormino EC. Dissociable influences ofε4 and polygenic risk of AD dementia on amyloid and cognition. Neurology. PMID 29592889 DOI: 10.1212/Wnl.0000000000005415  0.339
2018 Chhatwal JP, Schultz AP, Johnson KA, Hedden T, Jaimes S, Benzinger TLS, Jack C, Ances BM, Ringman JM, Marcus DS, Ghetti B, Farlow MR, Danek A, Levin J, Yakushev I, ... Sperling RA, et al. Preferential degradation of cognitive networks differentiates Alzheimer's disease from ageing. Brain : a Journal of Neurology. PMID 29522171 DOI: 10.1093/Brain/Awy053  0.319
2018 Quiroz YT, Sperling RA, Norton DJ, Baena A, Arboleda-Velasquez JF, Cosio D, Schultz A, Lapoint M, Guzman-Velez E, Miller JB, Kim LA, Chen K, Tariot PN, Lopera F, Reiman EM, et al. Association Between Amyloid and Tau Accumulation in Young Adults With Autosomal Dominant Alzheimer Disease. Jama Neurology. PMID 29435558 DOI: 10.1001/Jamaneurol.2017.4907  0.351
2018 Jacobs HIL, Hedden T, Schultz AP, Sepulcre J, Perea RD, Amariglio RE, Papp KV, Rentz DM, Sperling RA, Johnson KA. Structural tract alterations predict downstream tau accumulation in amyloid-positive older individuals. Nature Neuroscience. PMID 29403032 DOI: 10.1038/s41593-018-0070-z  0.382
2018 Klinger RY, James OG, Borges-Neto S, Bisanar T, Li YJ, Qi W, Berger M, Terrando N, Newman MF, Doraiswamy PM, Mathew JP, Weiner MW, Aisen P, Weiner M, Aisen P, ... ... Sperling RA, ... ... Sperling RA, et al. 18F-florbetapir Positron Emission Tomography-determined Cerebral β-Amyloid Deposition and Neurocognitive Performance after Cardiac Surgery. Anesthesiology. PMID 29389750 DOI: 10.1097/Aln.0000000000002103  0.692
2018 d'Oleire Uquillas F, Jacobs HIL, Hanseeuw B, Marshall GA, Properzi M, Schultz AP, LaPoint MR, Johnson KA, Sperling RA, Vannini P. Interactive versus additive relationships between regional cortical thinning and amyloid burden in predicting clinical decline in mild AD and MCI individuals. Neuroimage. Clinical. 17: 388-396. PMID 29159051 DOI: 10.1016/j.nicl.2017.10.034  0.796
2017 Papp KV, Rentz DM, Orlovsky I, Sperling RA, Mormino EC. Optimizing the preclinical Alzheimer's cognitive composite with semantic processing: The PACC5. Alzheimer's & Dementia (New York, N. Y.). 3: 668-677. PMID 29264389 DOI: 10.1016/j.trci.2017.10.004  0.333
2017 Jackson JD, Rentz DM, Aghjayan SL, Buckley RF, Meneide TF, Sperling RA, Amariglio RE. Subjective cognitive concerns are associated with objective memory performance in Caucasian but not African-American persons. Age and Ageing. 46: 988-993. PMID 29088363 DOI: 10.1093/ageing/afx077  0.374
2017 Dumurgier J, Hanseeuw BJ, Hatling FB, Judge KA, Schultz AP, Chhatwal JP, Blacker D, Sperling RA, Johnson KA, Hyman BT, Gómez-Isla T. Alzheimer's Disease Biomarkers and Future Decline in Cognitive Normal Older Adults. Journal of Alzheimer's Disease : Jad. PMID 29036824 DOI: 10.3233/Jad-170511  0.338
2017 Buckley RF, Hanseeuw B, Schultz AP, Vannini P, Aghjayan SL, Properzi MJ, Jackson JD, Mormino EC, Rentz DM, Sperling RA, Johnson KA, Amariglio RE. Region-Specific Association of Subjective Cognitive Decline With Tauopathy Independent of Global β-Amyloid Burden. Jama Neurology. PMID 28973551 DOI: 10.1001/jamaneurol.2017.2216  0.369
2017 Norton DJ, Amariglio R, Protas H, Chen K, Aguirre-Acevedo DC, Pulsifer B, Castrillon G, Tirado V, Munoz C, Tariot P, Langbaum JB, Reiman EM, Lopera F, Sperling RA, Quiroz YT. Subjective memory complaints in preclinical autosomal dominant Alzheimer disease. Neurology. PMID 28878053 DOI: 10.1212/Wnl.0000000000004533  0.316
2017 Aisen PS, Cummings J, Jack CR, Morris JC, Sperling R, Frölich L, Jones RW, Dowsett SA, Matthews BR, Raskin J, Scheltens P, Dubois B. On the path to 2025: understanding the Alzheimer's disease continuum. Alzheimer's Research & Therapy. 9: 60. PMID 28793924 DOI: 10.1186/S13195-017-0283-5  0.414
2017 Gatchel JR, Donovan NJ, Locascio JJ, Schultz AP, Becker JA, Chhatwal J, Papp KV, Amariglio RE, Rentz DM, Blacker D, Sperling RA, Johnson KA, Marshall GA. Depressive Symptoms and Tau Accumulation in the Inferior Temporal Lobe and Entorhinal Cortex in Cognitively Normal Older Adults: A Pilot Study. Journal of Alzheimer's Disease : Jad. PMID 28697559 DOI: 10.3233/Jad-170001  0.303
2017 Vannini P, Hanseeuw B, Munro CE, Amariglio RE, Marshall GA, Rentz DM, Pascual-Leone A, Johnson KA, Sperling RA. Anosognosia for memory deficits in mild cognitive impairment: Insight into the neural mechanism using functional and molecular imaging. Neuroimage. Clinical. 15: 408-414. PMID 28616381 DOI: 10.1016/j.nicl.2017.05.020  0.398
2017 Buckley RF, Schultz AP, Hedden T, Papp KV, Hanseeuw BJ, Marshall G, Sepulcre J, Smith EE, Rentz DM, Johnson KA, Sperling RA, Chhatwal JP. Functional network integrity presages cognitive decline in preclinical Alzheimer disease. Neurology. PMID 28592457 DOI: 10.1212/Wnl.0000000000004059  0.336
2017 Sepulcre J, Grothe MJ, Sabuncu M, Chhatwal J, Schultz AP, Hanseeuw B, El Fakhri G, Sperling R, Johnson KA. Hierarchical Organization of Tau and Amyloid Deposits in the Cerebral Cortex. Jama Neurology. PMID 28558094 DOI: 10.1001/Jamaneurol.2017.0263  0.433
2017 Müller S, Preische O, Sohrabi HR, Gräber S, Jucker M, Dietzsch J, Ringman JM, Martins RN, McDade E, Schofield PR, Ghetti B, Rossor M, Graff-Radford NR, Levin J, Galasko D, ... ... Sperling R, et al. Decreased body mass index in the preclinical stage of autosomal dominant Alzheimer's disease. Scientific Reports. 7: 1225. PMID 28450713 DOI: 10.1038/S41598-017-01327-W  0.376
2017 Gatchel JR, Donovan NJ, Locascio JJ, Becker JA, Rentz DM, Sperling RA, Johnson KA, Marshall GA. Regional 18F-Fluorodeoxyglucose Hypometabolism is Associated with Higher Apathy Scores Over Time in Early Alzheimer Disease. The American Journal of Geriatric Psychiatry : Official Journal of the American Association For Geriatric Psychiatry. PMID 28410856 DOI: 10.1016/j.jagp.2016.12.017  0.374
2017 Vannini P, Amariglio R, Hanseeuw B, Johnson KA, McLaren DG, Chhatwal J, Pascual-Leone A, Rentz D, Sperling RA. Memory self-awareness in the preclinical and prodromal stages of Alzheimer's disease. Neuropsychologia. PMID 28385579 DOI: 10.1016/J.Neuropsychologia.2017.04.002  0.396
2017 Vannini P, Hanseeuw B, Munro CE, Amariglio RE, Marshall GA, Rentz DM, Pascual-Leone A, Johnson KA, Sperling RA. Hippocampal hypometabolism in older adults with memory complaints and increased amyloid burden. Neurology. PMID 28381517 DOI: 10.1212/WNL.0000000000003889  0.315
2017 Sepulcre J, Sabuncu MR, Li Q, El Fakhri G, Sperling R, Johnson KA. Tau and Aβ proteins distinctively associate to functional network changes in the aging brain. Alzheimer's & Dementia : the Journal of the Alzheimer's Association. PMID 28366797 DOI: 10.1016/J.Jalz.2017.02.011  0.406
2017 Schultz AP, Chhatwal JP, Hedden T, Mormino EC, Hanseeuw BJ, Sepulcre J, Huijbers W, LaPoint M, Buckley RF, Johnson KA, Sperling RA. Phases of hyper and hypo connectivity in the Default Mode and Salience networks track with amyloid and Tau in clinically normal individuals. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. PMID 28314821 DOI: 10.1523/Jneurosci.3263-16.2017  0.705
2017 Papp KV, Rentz DM, Mormino EC, Schultz AP, Amariglio RE, Quiroz Y, Johnson KA, Sperling RA. Cued memory decline in biomarker-defined preclinical Alzheimer disease. Neurology. PMID 28283594 DOI: 10.1212/Wnl.0000000000003812  0.344
2017 Hanseeuw BJ, Betensky RA, Schultz AP, Papp KV, Mormino EC, Sepulcre J, Bark JS, Cosio DM, LaPoint M, Chhatwal JP, Rentz DM, Sperling RA, Johnson K. FDG metabolism associated with tau-amyloid interaction predicts memory decline. Annals of Neurology. PMID 28253546 DOI: 10.1002/Ana.24910  0.351
2017 Mormino EC, Papp KV, Rentz DM, Donohue MC, Amariglio R, Quiroz YT, Chhatwal J, Marshall GA, Donovan N, Jackson J, Gatchel JR, Hanseeuw BJ, Schultz AP, Aisen PS, Johnson KA, Sperling RA, et al. Early and late change on the preclinical Alzheimer's cognitive composite in clinically normal older individuals with elevated β-amyloid. Alzheimer's & Dementia : the Journal of the Alzheimer's Association. PMID 28253478 DOI: 10.1016/J.Jalz.2017.01.018  0.321
2017 Huijbers W, Schultz AP, Papp KV, LaPoint MR, Chhatwal JP, Hedden T, Johnson K, Sperling RA. TAU ACCUMULATION IN CLINICALLY NORMAL OLDER ADULTS IS ASSOCIATED WITH INCREASES IN HIPPOCAMPAL FMRI ACTIVITY Alzheimer's & Dementia. 13: P1215. DOI: 10.1016/J.Jalz.2017.07.388  0.657
2017 Papp KV, Mormino BC, Huijbers W, Dickerson BC, Orlovsky I, Schultz AP, Sperling RA, Rentz DM, Johnson K. SEMANTIC MEMORY AND PET AMYLOID AND TAU DEPOSITION IN PRECLINICAL AND PRODROMAL ALZHEIMER’S DISEASE Alzheimer's & Dementia. 13: P911-P912. DOI: 10.1016/J.Jalz.2017.07.333  0.739
2017 Yang H, Yu L, White CC, Sperling RA, Bennett DA, Schneider JA, De Jager PL. [P2-115]: A TMEM106B LOCUS IS IMPLICATED IN COGNITIVE DECLINE IN ALZHEIMER's DISEASE Alzheimer's & Dementia. 13: P650-P651. DOI: 10.1016/J.Jalz.2017.06.765  0.31
2016 Prčkovska V, Huijbers W, Schultz A, Ortiz-Teran L, Peña-Gomez C, Villoslada P, Johnson K, Sperling R, Sepulcre J. Epicenters of dynamic connectivity in the adaptation of the ventral visual system. Human Brain Mapping. PMID 28029725 DOI: 10.1002/Hbm.23497  0.624
2016 Molinuevo JL, Rabin LA, Amariglio R, Buckley R, Dubois B, Ellis KA, Ewers M, Hampel H, Klöppel S, Rami L, Reisberg B, Saykin AJ, Sikkes S, Smart CM, Snitz BE, Sperling R, et al. Implementation of subjective cognitive decline criteria in research studies. Alzheimer's & Dementia : the Journal of the Alzheimer's Association. PMID 27825022 DOI: 10.1016/J.Jalz.2016.09.012  0.438
2016 Donovan NJ, Okereke OI, Vannini P, Amariglio RE, Rentz DM, Marshall GA, Johnson KA, Sperling RA. Association of Higher Cortical Amyloid Burden With Loneliness in Cognitively Normal Older Adults. Jama Psychiatry. PMID 27806159 DOI: 10.1001/jamapsychiatry.2016.2657  0.367
2016 Rentz DM, Mormino EC, Papp KV, Betensky RA, Sperling RA, Johnson KA. Cognitive resilience in clinical and preclinical Alzheimer's disease: the Association of Amyloid and Tau Burden on cognitive performance. Brain Imaging and Behavior. PMID 27738998 DOI: 10.1007/s11682-016-9640-4  0.319
2016 Aghjayan SL, Buckley RF, Vannini P, Rentz DM, Jackson JD, Sperling RA, Johnson KA, Amariglio RE. The influence of demographic factors on subjective cognitive concerns and beta-amyloid. International Psychogeriatrics. 1-8. PMID 27724996 DOI: 10.1017/S1041610216001502  0.366
2016 Zhang X, Mormino EC, Sun N, Sperling RA, Sabuncu MR, Yeo BT. Bayesian model reveals latent atrophy factors with dissociable cognitive trajectories in Alzheimer's disease. Proceedings of the National Academy of Sciences of the United States of America. PMID 27702899 DOI: 10.1073/Pnas.1611073113  0.357
2016 Albers AD, Asafu-Adjei J, Delaney MK, Kelly KE, Gomez-Isla T, Blacker D, Johnson KA, Sperling RA, Hyman BT, Betensky RA, Hastings L, Albers MW. Episodic Memory of Odors Stratifies Alzheimer Biomarkers in Normal Elderly. Annals of Neurology. PMID 27696605 DOI: 10.1002/Ana.24792  0.373
2016 Gomperts SN, Locascio JJ, Makaretz SJ, Schultz A, Caso C, Vasdev N, Sperling R, Growdon JH, Dickerson BC, Johnson K. Tau Positron Emission Tomographic Imaging in the Lewy Body Diseases. Jama Neurology. PMID 27654968 DOI: 10.1001/Jamaneurol.2016.3338  0.548
2016 Huijbers W, Papp KV, LaPoint M, Wigman SE, Dagley A, Hedden T, Rentz DM, Schultz AP, Sperling RA. Age-Related Increases in Tip-of-the-tongue are Distinct from Decreases in Remembering Names: A Functional MRI Study. Cerebral Cortex (New York, N.Y. : 1991). PMID 27578492 DOI: 10.1093/Cercor/Bhw234  0.682
2016 Mormino EC, Papp KV, Rentz DM, Schultz AP, LaPoint M, Amariglio R, Hanseeuw B, Marshall GA, Hedden T, Johnson KA, Sperling RA. Heterogeneity in Suspected Non-Alzheimer Disease Pathophysiology Among Clinically Normal Older Individuals. Jama Neurology. PMID 27548655 DOI: 10.1001/jamaneurol.2016.2237  0.303
2016 Buckley RF, Villemagne VL, Masters CL, Ellis KA, Rowe CC, Johnson K, Sperling R, Amariglio R. A Conceptualization of the Utility of Subjective Cognitive Decline in Clinical Trials of Preclinical Alzheimer's Disease. Journal of Molecular Neuroscience : Mn. PMID 27514526 DOI: 10.1007/S12031-016-0810-Z  0.461
2016 Hanseeuw BJ, Schultz AP, Betensky RA, Sperling RA, Johnson KA. Decreased hippocampal metabolism in high-amyloid mild cognitive impairment. Alzheimer's & Dementia : the Journal of the Alzheimer's Association. PMID 27421609 DOI: 10.1016/j.jalz.2016.06.2357  0.328
2016 Sepulcre J, Schultz AP, Sabuncu M, Gomez-Isla T, Chhatwal J, Becker A, Sperling R, Johnson KA. In Vivo Tau, Amyloid, and Gray Matter Profiles in the Aging Brain. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 36: 7364-74. PMID 27413148 DOI: 10.1523/Jneurosci.0639-16.2016  0.423
2016 Tarrant SD, Bardach SH, Bates K, Nichols H, Towner J, Tamatha C, Caban-Holt A, Van-Eldik LJ, Murphy RR, Sperling R, Jicha GA. The Effectiveness of Small-group Community-based Information Sessions on Clinical Trial Recruitment for Secondary Prevention of Alzheimer's Disease. Alzheimer Disease and Associated Disorders. PMID 27213625 DOI: 10.1097/Wad.0000000000000151  0.322
2016 Fotiadis P, van Rooden S, van der Grond J, Schultz A, Martinez-Ramirez S, Auriel E, Reijmer Y, van Opstal AM, Ayres A, Schwab KM, Alzheimer's Disease Neuroimaging Initiative Adni, Hedden T, Rosand J, Viswanathan A, Wermer M, ... Sperling RA, et al. Cortical atrophy in patients with cerebral amyloid angiopathy: a case-control study. The Lancet. Neurology. PMID 27180034 DOI: 10.1016/S1474-4422(16)30030-8  0.326
2016 Weninger S, Carrillo MC, Dunn B, Aisen PS, Bateman RJ, Kotz JD, Langbaum JB, Mills SL, Reiman EM, Sperling R, Santacruz AM, Tariot PN, Welsh-Bohmer KA. Collaboration for Alzheimer's Prevention: Principles to guide data and sample sharing in preclinical Alzheimer's disease trials. Alzheimer's & Dementia : the Journal of the Alzheimer's Association. 12: 631-2. PMID 27157073 DOI: 10.1016/J.Jalz.2016.04.001  0.386
2016 Rieckmann A, Van Dijk KR, Sperling RA, Johnson KA, Buckner RL, Hedden T. Accelerated decline in white matter integrity in clinically normal individuals at risk for Alzheimer's disease. Neurobiology of Aging. 42: 177-88. PMID 27143434 DOI: 10.1016/j.neurobiolaging.2016.03.016  0.321
2016 Rabinovici GD, Karlawish J, Knopman D, Snyder HM, Sperling R, Carrillo MC. Testing and disclosures related to amyloid imaging and Alzheimer's disease: Common questions and fact sheet summary. Alzheimer's & Dementia : the Journal of the Alzheimer's Association. 12: 510-5. PMID 27103054 DOI: 10.1016/J.Jalz.2016.03.002  0.441
2016 Hendrix JA, Bateman RJ, Brashear HR, Duggan C, Carrillo MC, Bain LJ, DeMattos R, Katz RG, Ostrowitzki S, Siemers E, Sperling R, Vitolo OV. Challenges, solutions, and recommendations for Alzheimer's disease combination therapy. Alzheimer's & Dementia : the Journal of the Alzheimer's Association. PMID 27017906 DOI: 10.1016/J.Jalz.2016.02.007  0.36
2016 Lee S, Viqar F, Zimmerman ME, Narkhede A, Tosto G, Benzinger TL, Marcus DS, Fagan AM, Goate A, Fox NC, Cairns NJ, Holtzman DM, Buckles V, Ghetti B, McDade E, ... ... Sperling RA, et al. White matter hyperintensities are a core feature of Alzheimer's disease: Evidence from the Dominantly Inherited Alzheimer Network. Annals of Neurology. PMID 27016429 DOI: 10.1002/ana.24647  0.324
2016 Dubois B, Hampel H, Feldman HH, Scheltens P, Aisen P, Andrieu S, Bakardjian H, Benali H, Bertram L, Blennow K, Broich K, Cavedo E, Crutch S, Dartigues JF, Duyckaerts C, ... ... Sperling R, et al. Preclinical Alzheimer's disease: Definition, natural history, and diagnostic criteria. Alzheimer's & Dementia : the Journal of the Alzheimer's Association. 12: 292-323. PMID 27012484 DOI: 10.1016/J.Jalz.2016.02.002  0.362
2016 Molinuevo JL, Cami J, Carné X, Carrillo MC, Georges J, Isaac MB, Khachaturian Z, Kim SY, Morris JC, Pasquier F, Ritchie C, Sperling R, Karlawish J. Ethical challenges in preclinical Alzheimer's disease observational studies and trials: Results of the Barcelona summit. Alzheimer's & Dementia : the Journal of the Alzheimer's Association. PMID 26988427 DOI: 10.1016/J.Jalz.2016.01.009  0.373
2016 Winblad B, Amouyel P, Andrieu S, Ballard C, Brayne C, Brodaty H, Cedazo-Minguez A, Dubois B, Edvardsson D, Feldman H, Fratiglioni L, Frisoni GB, Gauthier S, Georges J, Graff C, ... ... Sperling R, et al. Defeating Alzheimer's disease and other dementias: a priority for European science and society. The Lancet. Neurology. 15: 455-532. PMID 26987701 DOI: 10.1016/S1474-4422(16)00062-4  0.396
2016 Jack CR, Knopman DS, Chételat G, Dickson D, Fagan AM, Frisoni GB, Jagust W, Mormino EC, Petersen RC, Sperling RA, van der Flier WM, Villemagne VL, Visser PJ, Vos SJ. Suspected non-Alzheimer disease pathophysiology - concept and controversy. Nature Reviews. Neurology. PMID 26782335 DOI: 10.1038/Nrneurol.2015.251  0.31
2016 Sperling R. Secondary prevention trials in preclinical Alzheimer's disease Neurobiology of Aging. 39. DOI: 10.1016/J.Neurobiolaging.2016.01.078  0.378
2015 Marshall GA, Dekhtyar M, Bruno JM, Jethwani K, Amariglio RE, Johnson KA, Sperling RA, Rentz DM. The Harvard Automated Phone Task: new performance-based activities of daily living tests for early Alzheimer's disease. The Journal of Prevention of Alzheimer's Disease. 2: 242-253. PMID 26665121 DOI: 10.14283/jpad.2015.72  0.344
2015 Malishkevich A, Marshall GA, Schultz AP, Sperling RA, Aharon-Peretz J, Gozes I. Blood-Borne Activity-Dependent Neuroprotective Protein (ADNP) is Correlated with Premorbid Intelligence, Clinical Stage, and Alzheimer's Disease Biomarkers. Journal of Alzheimer's Disease : Jad. PMID 26639975 DOI: 10.3233/JAD-150799  0.375
2015 Papp KV, Mormino EC, Amariglio RE, Munro C, Dagley A, Schultz AP, Johnson KA, Sperling RA, Rentz DM. Biomarker Validation of a Decline in Semantic Processing in Preclinical Alzheimer's Disease. Neuropsychology. PMID 26595826 DOI: 10.1037/neu0000246  0.377
2015 Johnson KA, Schultz A, Betensky RA, Becker JA, Sepulcre J, Rentz D, Mormino E, Chhatwal J, Amariglio R, Papp K, Marshall G, Albers M, Mauro S, Pepin L, Alverio J, ... Sperling R, et al. Tau PET imaging in aging and early Alzheimer's disease. Annals of Neurology. PMID 26505746 DOI: 10.1002/Ana.24546  0.589
2015 Reiman EM, Langbaum JB, Tariot PN, Lopera F, Bateman RJ, Morris JC, Sperling RA, Aisen PS, Roses AD, Welsh-Bohmer KA, Carrillo MC, Weninger S. CAP-advancing the evaluation of preclinical Alzheimer disease treatments. Nature Reviews. Neurology. PMID 26416539 DOI: 10.1038/Nrneurol.2015.177  0.301
2015 Guercio BJ, Donovan NJ, Munro CE, Aghjayan SL, Wigman SE, Locascio JJ, Amariglio RE, Rentz DM, Johnson KA, Sperling RA, Marshall GA. The Apathy Evaluation Scale: A Comparison of Subject, Informant, and Clinician Report in Cognitively Normal Elderly and Mild Cognitive Impairment. Journal of Alzheimer's Disease : Jad. 47: 421-32. PMID 26401564 DOI: 10.3233/JAD-150146  0.346
2015 Salloway S, Sperling R. Understanding Conflicting Neuropathological Findings in Patients Clinically Diagnosed as Having Alzheimer Dementia. Jama Neurology. 72: 1106-8. PMID 26302229 DOI: 10.1001/Jamaneurol.2015.1804  0.395
2015 Hyman BT, Growdon JH, Albers MW, Buckner RL, Chhatwal J, Gomez-Isla MT, Haass C, Hudry E, Jack CR, Johnson KA, Khachaturian ZS, Kim DY, Martin JB, Nitsch RM, Rosen BR, ... ... Sperling RA, et al. Massachusetts Alzheimer's Disease Research Center: Progress and challenges. Alzheimer's & Dementia : the Journal of the Alzheimer's Association. PMID 26297855 DOI: 10.1016/J.Jalz.2015.06.1887  0.451
2015 Vellas B, Bateman R, Blennow K, Frisoni G, Johnson K, Katz R, Langbaum J, Marson D, Sperling R, Wessels A, Salloway S, Doody R, Aisen P. Endpoints for Pre-Dementia AD Trials: A Report from the EU/US/CTAD Task Force. The Journal of Prevention of Alzheimer's Disease. 2: 128-135. PMID 26247004 DOI: 10.14283/jpad.2015.55  0.302
2015 Wang F, Gordon BA, Ryman DC, Ma S, Xiong C, Hassenstab J, Goate A, Fagan AM, Cairns NJ, Marcus DS, McDade E, Ringman JM, Graff-Radford NR, Ghetti B, Farlow MR, Sperling R, et al. Cerebral amyloidosis associated with cognitive decline in autosomal dominant Alzheimer disease. Neurology. PMID 26245925 DOI: 10.1212/Wnl.0000000000001903  0.405
2015 Toledo JB, Zetterberg H, van Harten AC, Glodzik L, Martinez-Lage P, Bocchio-Chiavetto L, Rami L, Hansson O, Sperling R, Engelborghs S, Osorio RS, Vanderstichele H, Vandijck M, Hampel H, Teipl S, et al. Alzheimer's disease cerebrospinal fluid biomarker in cognitively normal subjects. Brain : a Journal of Neurology. 138: 2701-15. PMID 26220940 DOI: 10.1093/Brain/Awv199  0.537
2015 Liu E, Schmidt ME, Margolin R, Sperling R, Koeppe R, Mason NS, Klunk WE, Mathis CA, Salloway S, Fox NC, Hill DL, Les AS, Collins P, Gregg KM, Di J, et al. Amyloid-β 11C-PiB-PET imaging results from 2 randomized bapineuzumab phase 3 AD trials. Neurology. PMID 26208959 DOI: 10.1212/Wnl.0000000000001877  0.327
2015 Quiroz YT, Schultz AP, Chen K, Protas HD, Brickhouse M, Fleisher AS, Langbaum JB, Thiyyagura P, Fagan AM, Shah AR, Muniz M, Arboleda-Velasquez JF, Munoz C, Garcia G, Acosta-Baena N, ... ... Sperling RA, et al. Brain Imaging and Blood Biomarker Abnormalities in Children With Autosomal Dominant Alzheimer Disease: A Cross-Sectional Study. Jama Neurology. PMID 26121081 DOI: 10.1001/Jamaneurol.2015.1099  0.471
2015 Gidicsin CM, Maye JE, Locascio JJ, Pepin LC, Philiossaint M, Becker JA, Younger AP, Dekhtyar M, Schultz AP, Amariglio RE, Marshall GA, Rentz DM, Hedden T, Sperling RA, Johnson KA. Cognitive activity relates to cognitive performance but not to Alzheimer disease biomarkers. Neurology. 85: 48-55. PMID 26062627 DOI: 10.1212/Wnl.0000000000001704  0.306
2015 Marshall GA, Zoller AS, Lorius N, Amariglio RE, Locascio JJ, Johnson KA, Sperling RA, Rentz DM, For The Alzheimer's Disease Neuroimaging Initiative EY. Functional Activities Questionnaire Items that Best Discriminate and Predict Progression from Clinically Normal to Mild Cognitive Impairment. Current Alzheimer Research. 12: 493-502. PMID 26017560  0.364
2015 Papp KV, Amariglio RE, Mormino EC, Hedden T, Dekhytar M, Johnson KA, Sperling RA, Rentz DM. Free and cued memory in relation to biomarker-defined abnormalities in clinically normal older adults and those at risk for Alzheimer's disease. Neuropsychologia. 73: 169-75. PMID 26002757 DOI: 10.1016/j.neuropsychologia.2015.04.034  0.395
2015 Harkins K, Sankar P, Sperling R, Grill JD, Green RC, Johnson KA, Healy M, Karlawish J. Development of a process to disclose amyloid imaging results to cognitively normal older adult research participants. Alzheimer's Research & Therapy. 7: 26. PMID 25969699 DOI: 10.1186/S13195-015-0112-7  0.375
2015 Munro CE, Donovan NJ, Guercio BJ, Wigman SE, Schultz AP, Amariglio RE, Rentz DM, Johnson KA, Sperling RA, Marshall GA. Neuropsychiatric Symptoms and Functional Connectivity in Mild Cognitive Impairment. Journal of Alzheimer's Disease : Jad. PMID 25854929 DOI: 10.3233/JAD-150017  0.328
2015 Dagley A, LaPoint M, Huijbers W, Hedden T, McLaren DG, Chatwal JP, Papp KV, Amariglio RE, Blacker D, Rentz DM, Johnson KA, Sperling RA, Schultz AP. Harvard Aging Brain Study: Dataset and accessibility. Neuroimage. PMID 25843019 DOI: 10.1016/J.Neuroimage.2015.03.069  0.619
2015 Mattsson N, Insel PS, Donohue M, Jagust W, Sperling R, Aisen P, Weiner MW. Predicting Reduction of Cerebrospinal Fluid β-Amyloid 42 in Cognitively Healthy Controls. Jama Neurology. 72: 554-60. PMID 25775167 DOI: 10.1001/Jamaneurol.2014.4530  0.4
2015 Guercio BJ, Donovan NJ, Ward A, Schultz A, Lorius N, Amariglio RE, Rentz DM, Johnson KA, Sperling RA, Marshall GA. Apathy is associated with lower inferior temporal cortical thickness in mild cognitive impairment and normal elderly individuals. The Journal of Neuropsychiatry and Clinical Neurosciences. 27: e22-7. PMID 25716491 DOI: 10.1176/appi.neuropsych.13060141  0.34
2015 Perry D, Sperling R, Katz R, Berry D, Dilts D, Hanna D, Salloway S, Trojanowski JQ, Bountra C, Krams M, Luthman J, Potkin S, Gribkoff V, Temple R, Wang Y, et al. Building a roadmap for developing combination therapies for Alzheimer's disease. Expert Review of Neurotherapeutics. 15: 327-33. PMID 25708309 DOI: 10.1586/14737175.2015.996551  0.359
2015 Amariglio RE, Donohue MC, Marshall GA, Rentz DM, Salmon DP, Ferris SH, Karantzoulis S, Aisen PS, Sperling RA. Tracking early decline in cognitive function in older individuals at risk for Alzheimer disease dementia: the Alzheimer's Disease Cooperative Study Cognitive Function Instrument. Jama Neurology. 72: 446-54. PMID 25706191 DOI: 10.1001/Jamaneurol.2014.3375  0.352
2015 Huijbers W, Mormino EC, Schultz AP, Wigman S, Ward AM, Larvie M, Amariglio RE, Marshall GA, Rentz DM, Johnson KA, Sperling RA. Amyloid-β deposition in mild cognitive impairment is associated with increased hippocampal activity, atrophy and clinical progression. Brain : a Journal of Neurology. 138: 1023-35. PMID 25678559 DOI: 10.1093/Brain/Awv007  0.706
2015 Replogle JM, Chan G, White CC, Raj T, Winn PA, Evans DA, Sperling RA, Chibnik LB, Bradshaw EM, Schneider JA, Bennett DA, De Jager PL. A TREM1 variant alters the accumulation of Alzheimer-related amyloid pathology. Annals of Neurology. 77: 469-77. PMID 25545807 DOI: 10.1002/Ana.24337  0.339
2015 Stephenson D, Perry D, Bens C, Bain LJ, Berry D, Krams M, Sperling R, Dilts D, Luthman J, Hanna D, McKew J, Temple R, Fields FO, Salloway S, Katz R. Charting a path toward combination therapy for Alzheimer's disease. Expert Review of Neurotherapeutics. 15: 107-13. PMID 25540951 DOI: 10.1586/14737175.2015.995168  0.366
2015 Ward AM, Mormino EC, Huijbers W, Schultz AP, Hedden T, Sperling RA. Relationships between default-mode network connectivity, medial temporal lobe structure, and age-related memory deficits. Neurobiology of Aging. 36: 265-72. PMID 25113793 DOI: 10.1016/J.Neurobiolaging.2014.06.028  0.675
2015 Lorius N, Locascio JJ, Rentz DM, Johnson KA, Sperling RA, Viswanathan A, Marshall GA. Vascular disease and risk factors are associated with cognitive decline in the alzheimer disease spectrum. Alzheimer Disease and Associated Disorders. 29: 18-25. PMID 24787033 DOI: 10.1097/WAD.0000000000000043  0.346
2015 Toledo JB, Zetterberg H, Van Harten AC, Glodzik L, Martinez-Lage P, Bocchio-Chiavetto L, Rami L, Hansson O, Sperling R, Engelborghs S, Osorio RS, Vanderstichele H, Vandijck M, Hampel H, Teipl S, et al. Alzheimer's disease cerebrospinal fluid biomarker in cognitively normal subjects Brain. 138: 2701-2715. DOI: 10.1093/brain/awv199  0.472
2015 Quiroz YT, Schultz AP, Chen K, Protas HD, Brickhouse M, Fleisher AS, Langbaum JB, Thiyyagura P, Fagan AM, Shah AR, Muniz M, Arboleda-Velasquez JF, Munoz C, Garcia G, Acosta-Baena N, ... ... Sperling RA, et al. Brain imaging and blood biomarker abnormalities in children with autosomal dominant Alzheimer disease a cross-sectional study Jama Neurology. 72: 912-919.  0.46
2014 Cavedo E, Lista S, Khachaturian Z, Aisen P, Amouyel P, Herholz K, Jack CR, Sperling R, Cummings J, Blennow K, O'Bryant S, Frisoni GB, Khachaturian A, Kivipelto M, Klunk W, et al. The Road Ahead to Cure Alzheimer's Disease: Development of Biological Markers and Neuroimaging Methods for Prevention Trials Across all Stages and Target Populations. The Journal of Prevention of Alzheimer's Disease. 1: 181-202. PMID 26478889 DOI: 10.14283/jpad.2014.32  0.366
2014 Sperling R, Mormino E, Johnson K. The evolution of preclinical Alzheimer's disease: implications for prevention trials. Neuron. 84: 608-22. PMID 25442939 DOI: 10.1016/J.Neuron.2014.10.038  0.458
2014 Fargo KN, Aisen P, Albert M, Au R, Corrada MM, DeKosky S, Drachman D, Fillit H, Gitlin L, Haas M, Herrup K, Kawas C, Khachaturian AS, Khachaturian ZS, ... ... Sperling RA, et al. 2014 Report on the Milestones for the US National Plan to Address Alzheimer's Disease. Alzheimer's & Dementia : the Journal of the Alzheimer's Association. 10: S430-52. PMID 25341459 DOI: 10.1016/J.Jalz.2014.08.103  0.584
2014 Marshall GA, Zoller AS, Kelly KE, Amariglio RE, Locascio JJ, Johnson KA, Sperling RA, Rentz DM, For The Alzheimer's Disease Neuroimaging Initiative. Everyday cognition scale items that best discriminate between and predict progression from clinically normal to mild cognitive impairment. Current Alzheimer Research. 11: 853-61. PMID 25274110  0.306
2014 Zoller AS, Gaal IM, Royer CA, Locascio JJ, Amariglio RE, Blacker D, Okereke OI, Johnson KA, Sperling RA, Rentz DM, Marshall GA. SIST-M-IR activities of daily living items that best discriminate clinically normal elderly from those with mild cognitive impairment. Current Alzheimer Research. 11: 785-91. PMID 25212917 DOI: 10.2174/156720501108140910122220  0.454
2014 Schultz AP, Chhatwal JP, Huijbers W, Hedden T, van Dijk KR, McLaren DG, Ward AM, Wigman S, Sperling RA. Template based rotation: a method for functional connectivity analysis with a priori templates. Neuroimage. 102: 620-36. PMID 25150630 DOI: 10.1016/J.Neuroimage.2014.08.022  0.623
2014 Roy K, Pepin LC, Philiossaint M, Lorius N, Becker JA, Locascio JJ, Rentz DM, Sperling RA, Johnson KA, Marshall GA. Regional fluorodeoxyglucose metabolism and instrumental activities of daily living across the Alzheimer's disease spectrum. Journal of Alzheimer's Disease : Jad. 42: 291-300. PMID 24898635 DOI: 10.3233/JAD-131796  0.358
2014 Donohue MC, Sperling RA, Salmon DP, Rentz DM, Raman R, Thomas RG, Weiner M, Aisen PS. The preclinical Alzheimer cognitive composite: measuring amyloid-related decline. Jama Neurology. 71: 961-70. PMID 24886908 DOI: 10.1001/Jamaneurol.2014.803  0.319
2014 McLaren DG, Sperling RA, Atri A. Flexible modulation of network connectivity related to cognition in Alzheimer's disease. Neuroimage. 100: 544-57. PMID 24852459 DOI: 10.1016/J.Neuroimage.2014.05.032  0.324
2014 Papp KV, Amariglio RE, Dekhtyar M, Roy K, Wigman S, Bamfo R, Sherman J, Sperling RA, Rentz DM. Development of a psychometrically equivalent short form of the Face-Name Associative Memory Exam for use along the early Alzheimer's disease trajectory. The Clinical Neuropsychologist. 28: 771-85. PMID 24815535 DOI: 10.1080/13854046.2014.911351  0.377
2014 Jessen F, Amariglio RE, van Boxtel M, Breteler M, Ceccaldi M, Chételat G, Dubois B, Dufouil C, Ellis KA, van der Flier WM, Glodzik L, van Harten AC, de Leon MJ, McHugh P, Mielke MM, ... Sperling RA, et al. A conceptual framework for research on subjective cognitive decline in preclinical Alzheimer's disease. Alzheimer's & Dementia : the Journal of the Alzheimer's Association. 10: 844-52. PMID 24798886 DOI: 10.1016/J.Jalz.2014.01.001  0.544
2014 Mormino EC, Betensky RA, Hedden T, Schultz AP, Ward A, Huijbers W, Rentz DM, Johnson KA, Sperling RA. Amyloid and APOE ε4 interact to influence short-term decline in preclinical Alzheimer disease. Neurology. 82: 1760-7. PMID 24748674 DOI: 10.1212/Wnl.0000000000000431  0.697
2014 Huijbers W, Mormino EC, Wigman SE, Ward AM, Vannini P, McLaren DG, Becker JA, Schultz AP, Hedden T, Johnson KA, Sperling RA. Amyloid deposition is linked to aberrant entorhinal activity among cognitively normal older adults. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 34: 5200-10. PMID 24719099 DOI: 10.1523/Jneurosci.3579-13.2014  0.731
2014 Donovan NJ, Amariglio RE, Zoller AS, Rudel RK, Gomez-Isla T, Blacker D, Hyman BT, Locascio JJ, Johnson KA, Sperling RA, Marshall GA, Rentz DM. Subjective cognitive concerns and neuropsychiatric predictors of progression to the early clinical stages of Alzheimer disease. The American Journal of Geriatric Psychiatry : Official Journal of the American Association For Geriatric Psychiatry. 22: 1642-51. PMID 24698445 DOI: 10.1016/J.Jagp.2014.02.007  0.325
2014 Marshall GA, Lorius N, Locascio JJ, Hyman BT, Rentz DM, Johnson KA, Sperling RA. Regional cortical thinning and cerebrospinal biomarkers predict worsening daily functioning across the Alzheimer's disease spectrum. Journal of Alzheimer's Disease : Jad. 41: 719-28. PMID 24685624 DOI: 10.3233/Jad-132768  0.338
2014 Sperling RA, Rentz DM, Johnson KA, Karlawish J, Donohue M, Salmon DP, Aisen P. The A4 study: stopping AD before symptoms begin? Science Translational Medicine. 6: 228fs13. PMID 24648338 DOI: 10.1126/Scitranslmed.3007941  0.336
2014 Doraiswamy PM, Sperling RA, Johnson K, Reiman EM, Wong TZ, Sabbagh MN, Sadowsky CH, Fleisher AS, Carpenter A, Joshi AD, Lu M, Grundman M, Mintun MA, Skovronsky DM, Pontecorvo MJ, et al. Florbetapir F 18 amyloid PET and 36-month cognitive decline: a prospective multicenter study. Molecular Psychiatry. 19: 1044-51. PMID 24614494 DOI: 10.1038/Mp.2014.9  0.341
2014 Fagan AM, Xiong C, Jasielec MS, Bateman RJ, Goate AM, Benzinger TL, Ghetti B, Martins RN, Masters CL, Mayeux R, Ringman JM, Rossor MN, Salloway S, Schofield PR, Sperling RA, et al. Longitudinal change in CSF biomarkers in autosomal-dominant Alzheimer's disease. Science Translational Medicine. 6: 226ra30. PMID 24598588 DOI: 10.1126/Scitranslmed.3007901  0.334
2014 Serrano-Pozo A, Qian J, Monsell SE, Blacker D, Gómez-Isla T, Betensky RA, Growdon JH, Johnson KA, Frosch MP, Sperling RA, Hyman BT. Mild to moderate Alzheimer dementia with insufficient neuropathological changes. Annals of Neurology. 75: 597-601. PMID 24585367 DOI: 10.1002/Ana.24125  0.34
2014 Salloway S, Sperling R, Fox NC, Blennow K, Klunk W, Raskind M, Sabbagh M, Honig LS, Porsteinsson AP, Ferris S, Reichert M, Ketter N, Nejadnik B, Guenzler V, Miloslavsky M, et al. Two phase 3 trials of bapineuzumab in mild-to-moderate Alzheimer's disease. The New England Journal of Medicine. 370: 322-33. PMID 24450891 DOI: 10.1056/Nejmoa1304839  0.404
2014 Donovan NJ, Wadsworth LP, Lorius N, Locascio JJ, Rentz DM, Johnson KA, Sperling RA, Marshall GA. Regional cortical thinning predicts worsening apathy and hallucinations across the Alzheimer disease spectrum. The American Journal of Geriatric Psychiatry : Official Journal of the American Association For Geriatric Psychiatry. 22: 1168-79. PMID 23890751 DOI: 10.1016/j.jagp.2013.03.006  0.392
2014 Ward AM, Schultz AP, Huijbers W, Van Dijk KR, Hedden T, Sperling RA. The parahippocampal gyrus links the default-mode cortical network with the medial temporal lobe memory system. Human Brain Mapping. 35: 1061-73. PMID 23404748 DOI: 10.1002/Hbm.22234  0.666
2014 Sperling R, Mormino E, Schultz A, Rentz D, Aisen P, Johnson K. The Aging Brain - Does Amyloid Matter? Neurobiology of Aging. 35. DOI: 10.1016/J.Neurobiolaging.2014.01.111  0.307
2014 Johnson KA, Mormino E, Rentz DM, Schultz A, Becker JA, Sepulcre J, Chhatwal J, Amariglio R, Papp K, Marshall G, Shoup T, Yokell D, Brady T, Hyman B, Vasdev N, Sperling R, et al. DT-01-02: TEMPORAL NEOCORTICAL TAU DEPOSITION MEASURED WITH PET IS ASSOCIATED WITH LONGITUDINAL DECLINE IN MEMORY PERFORMANCE AMONG CLINICALLY NORMAL ELDERLY Alzheimer's & Dementia. 10: P280-P280. DOI: 10.1016/J.Jalz.2014.07.150  0.51
2014 Marshall G, Dekhtyar M, Bruno J, Roy K, Masters C, Jethwani K, Amariglio RE, Johnson K, Sperling R, Rentz DM. A New Performance-Based Activities Of Daily Living Instrument For Early Alzheimer'S Disease Alzheimers & Dementia. 10: 365. DOI: 10.1016/J.Jalz.2014.05.418  0.382
2014 Margolin R, Di J, Andrews R, Salloway S, Sperling R, Brashear HR, Liu E, Schmidt M, Matthews DC. Amyloid Burden-Related Performance Differences On Cognitive And Functional Instruments Across Alzheimer'S Disease Pathophysiologic Stages Alzheimers & Dementia. 10: 839. DOI: 10.1016/J.Jalz.2014.05.1656  0.468
2014 Growdon M, Schultz A, Dagley A, Amariglio RE, Hedden T, Rentz DM, Johnson K, Sperling R, Albers MW, Marshall G. Olfactory Identification And Alzheimer'S Disease Biomarkers In Clinically Normal Elderly Alzheimers & Dementia. 10: 87. DOI: 10.1016/J.Jalz.2014.05.159  0.368
2014 Munro CE, Donovan NJ, Guercio B, Wigman SE, Schultz A, Amariglio RE, Rentz DM, Johnson K, Sperling R, Marshall G. Neuropsychiatric Symptoms And Functional Connectivity In Mild Cognitive Impairment And Cognitively Normal Elderly Alzheimers & Dementia. 10: 729. DOI: 10.1016/J.Jalz.2014.05.1358  0.343
2014 Johnson KA, Schultz A, Becker A, Hyman B, Rentz D, Sepulcre J, Vasdev N, Sperling R, Brady T. Tau Pet Using F18-T807: Initial Experience In Normal Elderly And Ad Dementia Alzheimers & Dementia. 10: 242. DOI: 10.1016/J.Jalz.2014.04.365  0.349
2014 Huijbers W, Mormino E, Schultz A, Chhatwal J, Boot BP, Amariglio RE, Marshall G, Rentz DM, Johnson KA, Sperling R. O3-10-06: AMYLOID-β DEPOSITION IN MILD COGNITIVE IMPAIRMENT IS ASSOCIATED WITH HIPPOCAMPAL HYPERACTIVATION, ATROPHY, AND CLINICAL PROGRESSION Alzheimer's & Dementia. 10: P230-P230. DOI: 10.1016/J.Jalz.2014.04.328  0.637
2014 Sepulcre J, Johnson KA, Sperling R. F2-02-03: TAU AND AB DEPOSITS RELATE TO DISTINCTIVE FUNCTIONAL CONNECTIVITY DISRUPTIONS IN THE ELDERLY BRAIN Alzheimer's & Dementia. 10: P159-P160. DOI: 10.1016/J.Jalz.2014.04.143  0.306
2013 Rentz DM, Parra Rodriguez MA, Amariglio R, Stern Y, Sperling R, Ferris S. Promising developments in neuropsychological approaches for the detection of preclinical Alzheimer's disease: a selective review. Alzheimer's Research & Therapy. 5: 58. PMID 24257331 DOI: 10.1186/Alzrt222  0.406
2013 Marshall GA, Donovan NJ, Lorius N, Gidicsin CM, Maye J, Pepin LC, Becker JA, Amariglio RE, Rentz DM, Sperling RA, Johnson KA. Apathy is associated with increased amyloid burden in mild cognitive impairment. The Journal of Neuropsychiatry and Clinical Neurosciences. 25: 302-7. PMID 24247857 DOI: 10.1176/Appi.Neuropsych.12060156  0.326
2013 Ward AM, McLaren DG, Schultz AP, Chhatwal J, Boot BP, Hedden T, Sperling RA. Daytime sleepiness is associated with decreased default mode network connectivity in both young and cognitively intact elderly subjects. Sleep. 36: 1609-15. PMID 24179292 DOI: 10.5665/Sleep.3108  0.301
2013 Santiago JA, Scherzer CR, Potashkin JA, Hyman BT, Ivinson AJ, Trisini-Lipsanopoulos A, Dhima K, Bayer S, Lockhart KC, Yi T, Liao Z, Hoesing AN, Duong K, Roderick S, Sudarsky LR, ... ... Sperling R, et al. Specific splice variants are associated with Parkinson's disease Movement Disorders. 28: 1724-1727. PMID 24108702 DOI: 10.1002/mds.25635  0.362
2013 Salmon DP, Ferris SH, Thomas RG, Sano M, Cummings JL, Sperling RA, Petersen RC, Aisen PS. Age and apolipoprotein E genotype influence rate of cognitive decline in nondemented elderly. Neuropsychology. 27: 391-401. PMID 23876113 DOI: 10.1037/A0032707  0.336
2013 Vellas B, Carrillo MC, Sampaio C, Brashear HR, Siemers E, Hampel H, Schneider LS, Weiner M, Doody R, Khachaturian Z, Cedarbaum J, Grundman M, Broich K, Giacobini E, Dubois B, ... Sperling R, et al. Designing drug trials for Alzheimer's disease: what we have learned from the release of the phase III antibody trials: a report from the EU/US/CTAD Task Force. Alzheimer's & Dementia : the Journal of the Alzheimer's Association. 9: 438-44. PMID 23809364 DOI: 10.1016/J.Jalz.2013.03.007  0.377
2013 Sepulcre J, Sabuncu MR, Becker A, Sperling R, Johnson KA. In vivo characterization of the early states of the amyloid-beta network. Brain : a Journal of Neurology. 136: 2239-52. PMID 23801740 DOI: 10.1093/Brain/Awt146  0.465
2013 Sperling R, Johnson K. Biomarkers of Alzheimer disease: current and future applications to diagnostic criteria. Continuum (Minneapolis, Minn.). 19: 325-38. PMID 23558480 DOI: 10.1212/01.CON.0000429181.60095.99  0.343
2013 Carrillo MC, Brashear HR, Logovinsky V, Ryan JM, Feldman HH, Siemers ER, Abushakra S, Hartley DM, Petersen RC, Khachaturian AS, Sperling RA. Can we prevent Alzheimer's disease? Secondary "prevention" trials in Alzheimer's disease. Alzheimer's & Dementia : the Journal of the Alzheimer's Association. 9: 123-131.e1. PMID 23411394 DOI: 10.1016/J.Jalz.2012.12.004  0.329
2013 Huijbers W, Schultz AP, Vannini P, McLaren DG, Wigman SE, Ward AM, Hedden T, Sperling RA. The encoding/retrieval flip: interactions between memory performance and memory stage and relationship to intrinsic cortical networks. Journal of Cognitive Neuroscience. 25: 1163-79. PMID 23384193 DOI: 10.1162/Jocn_A_00366  0.67
2013 Yang T, Hong S, O'Malley T, Sperling RA, Walsh DM, Selkoe DJ. New ELISAs with high specificity for soluble oligomers of amyloid β-protein detect natural Aβ oligomers in human brain but not CSF. Alzheimer's & Dementia : the Journal of the Alzheimer's Association. 9: 99-112. PMID 23375565 DOI: 10.1016/J.Jalz.2012.11.005  0.461
2013 Johnson KA, Sperling RA, Gidicsin CM, Carmasin JS, Maye JE, Coleman RE, Reiman EM, Sabbagh MN, Sadowsky CH, Fleisher AS, Murali Doraiswamy P, Carpenter AP, Clark CM, Joshi AD, Lu M, et al. Florbetapir (F18-AV-45) PET to assess amyloid burden in Alzheimer's disease dementia, mild cognitive impairment, and normal aging. Alzheimer's & Dementia : the Journal of the Alzheimer's Association. 9: S72-83. PMID 23375563 DOI: 10.1016/J.Jalz.2012.10.007  0.34
2013 Sperling RA, Karlawish J, Johnson KA. Preclinical Alzheimer disease-the challenges ahead. Nature Reviews. Neurology. 9: 54-8. PMID 23183885 DOI: 10.1038/nrneurol.2012.241  0.31
2013 Quiroz YT, Stern CE, Reiman EM, Brickhouse M, Ruiz A, Sperling RA, Lopera F, Dickerson BC. Cortical atrophy in presymptomatic Alzheimer's disease presenilin 1 mutation carriers. Journal of Neurology, Neurosurgery, and Psychiatry. 84: 556-61. PMID 23134660 DOI: 10.1136/Jnnp-2012-303299  0.58
2013 Desikan RS, McEvoy LK, Holland D, Thompson WK, Brewer JB, Aisen PS, Andreassen OA, Hyman BT, Sperling RA, Dale AM. Apolipoprotein E epsilon4 does not modulate amyloid-β-associated neurodegeneration in preclinical Alzheimer disease. Ajnr. American Journal of Neuroradiology. 34: 505-10. PMID 22976236 DOI: 10.3174/Ajnr.A3267  0.335
2013 Sperling RA, Johnson KA, Doraiswamy PM, Reiman EM, Fleisher AS, Sabbagh MN, Sadowsky CH, Carpenter A, Davis MD, Lu M, Flitter M, Joshi AD, Clark CM, Grundman M, Mintun MA, et al. Amyloid deposition detected with florbetapir F 18 ((18)F-AV-45) is related to lower episodic memory performance in clinically normal older individuals. Neurobiology of Aging. 34: 822-31. PMID 22878163 DOI: 10.1016/j.neurobiolaging.2012.06.014  0.309
2013 Vannini P, Hedden T, Huijbers W, Ward A, Johnson KA, Sperling RA. The ups and downs of the posteromedial cortex: age- and amyloid-related functional alterations of the encoding/retrieval flip in cognitively normal older adults. Cerebral Cortex (New York, N.Y. : 1991). 23: 1317-28. PMID 22586140 DOI: 10.1093/Cercor/Bhs108  0.735
2013 Salloway S, Sperling R, Gregg K, Yu P, Joshi A, Lu M, Mintun M, Pontecorvo M, Booth K, Wyman B, Sun J, Sundell K, Schmidt M, Margolin R, Skovronsky D, et al. Incidence and clinical progression of placebo-treated amyloid-negative subjects with mild-to-moderate Alzheimer's disease (AD): Results from the phase III PET substudies of bapineuzumab and solanezumab Alzheimers & Dementia. 9. DOI: 10.1016/J.Jalz.2013.08.250  0.438
2013 Papp K, Amariglio R, Sperling R, Bamfo R, Wigman S, Rentz D. P2-273: Semantic memory and its relationship to episodic memory and amyloid burden in cognitively normal (CN) older adults and those with mild cognitive impairment (MCI) Alzheimer's & Dementia. 9: P457-P458. DOI: 10.1016/J.Jalz.2013.05.920  0.442
2013 Donovan N, Zoller A, Rudel R, Amariglio R, Locascio J, Johnson K, Sperling R, Marshall G, Rentz D. Neuropsychiatric and cognitive factors predict progression to mild cognitive impairment and dementia Alzheimers & Dementia. 9: 443. DOI: 10.1016/J.Jalz.2013.05.884  0.362
2013 Romano S, Potkin S, Barlas S, Sperling R, Kalali A, Siemers E, Logovinsky V. Designing the next generation of disease modification trials in people with early Alzheimer's disease: Learnings from recently completed programs in mild-to-moderate populations Alzheimers & Dementia. 9. DOI: 10.1016/J.Jalz.2013.05.625  0.325
2013 Einstein S, Bouix S, Nielsen C, Clegg S, Les A, Simon H, Hill D, Margolin R, Sperling R, Fox N, Liu E, Novak G. The impact of gradient field distortion on the calculation of brain atrophy in Alzheimer's disease, derived from volumetric MRI using the boundary shift integral Alzheimers & Dementia. 9: 105. DOI: 10.1016/J.Jalz.2013.05.561  0.326
2013 Langbaum J, High N, Aisen P, Albert M, Brown K, Comer M, Cummings J, Manly J, Petersen R, Sperling R, Strobel G, Weiner M, Tariot P, Reiman E. Development and implementation of the National Alzheimer's Prevention Registry Alzheimers & Dementia. 9: 280. DOI: 10.1016/J.Jalz.2013.05.560  0.501
2013 Vannini P, Wigman S, Ward A, Amariglio R, Marshall G, Schultz A, Dijk Kv, Huijbers W, Rentz D, Johnson K, Sperling R. Decreased resting state functional connectivity at baseline predicts subjective memory complaints after 1 year in cognitively normal individuals and individuals with mild cognitive impairment Alzheimers & Dementia. 9: 110. DOI: 10.1016/J.Jalz.2013.05.195  0.702
2013 Ward A, Mormino E, Schultz A, Hedden T, Johnson K, Sperling R. IC-P-188: Entorhinal thickness mediates the relationship between hippocampus volume and default-mode network connectivity independently of amyloid burden in cognitively intact elderly Alzheimer's & Dementia. 9: P106-P107. DOI: 10.1016/J.Jalz.2013.05.187  0.381
2013 Marshall G, Zoller A, Lorius N, Amariglio R, Locascio J, Johnson K, Sperling R, Rentz D. Functional activities questionnaire items that best predict disease progression in the clinically normal elderly Alzheimers & Dementia. 9: 779. DOI: 10.1016/J.Jalz.2013.05.1590  0.339
2013 Blazey T, Jack C, Kantarci K, Preboske G, Ringman J, Brickman A, Raichle M, Hornbeck R, Saykin A, Salloway S, McDade E, Rossor M, Fox N, Thompson P, Correia S, ... ... Sperling R, et al. Prevalence and growth of cerebral microhemorrhages in autosomal dominant Alzheimer's disease Alzheimers & Dementia. 9. DOI: 10.1016/J.Jalz.2013.05.100  0.343
2013 Schultz A, McLaren D, Chhatwal J, Evans K, Johnson K, Sperling R. IC-P-101: Increased cerebral blood flow in cognitively normal older adults with amyloid Alzheimer's & Dementia. 9: P58-P59. DOI: 10.1016/J.Jalz.2013.05.098  0.349
2013 Chhatwal J, Schultz A, Johnson K, Benzinger T, Jack C, Ances B, Sullivan C, Salloway S, Ringman J, Koeppe R, Marcus D, Thompson P, Saykin A, Correia S, Schofield P, ... ... Sperling R, et al. IC-P-082: Disrupted functional connectivity in autosomal dominant Alzheimer's disease demonstrates network specificity and precedes brain volume loss: Findings from DIAN Alzheimer's & Dementia. 9: P49-P50. DOI: 10.1016/J.Jalz.2013.05.079  0.388
2013 Wigman S, Mormino E, Schultz A, Ward A, Amariglio R, Huijbers W, Rentz D, Johnson K, Sperling R, Vannini P. IC-P-081: Differential anatomical correlates of objective and subjective memory in older individuals across a spectrum of memory impairment Alzheimer's & Dementia. 9: P49-P49. DOI: 10.1016/J.Jalz.2013.05.078  0.695
2013 Cash D, Ridgway G, Modat M, Ryan N, Kinnunen K, Cardoso J, Benzinger T, Jack CR, Raichle M, Marcus D, Ringman J, Thompson P, Ghetti B, Salloway S, Sperling R, et al. Dissociating volume and intensity differences in familial Alzheimer's disease Alzheimers & Dementia. 9: 603. DOI: 10.1016/J.Jalz.2013.05.075  0.339
2013 Huijbers W, Ward A, Wigman S, Mormino E, Vannini P, Becker J, Schultz A, Johnson K, Hedden T, Sperling R. IC-P-013: Dissociations between entorhinal and hippocampal activity in cognitively normal older adults with and without beta-amyloid deposition Alzheimer's & Dementia. 9: P17-P17. DOI: 10.1016/J.Jalz.2013.05.014  0.695
2013 Chhatwal J, Schultz A, Johnson K, Benzinger T, Jack C, Ances B, Sullivan C, Salloway S, Ringman J, Koeppe R, Marcus D, Thompson P, Saykin A, Correia S, Schofield P, ... ... Sperling R, et al. O4-03-03: Disrupted functional connectivity in autosomal dominant Alzheimer's disease demonstrates network specificity and precedes brain volume loss: Findings from the Dominantly Inherited Alzheimer Network Alzheimer's & Dementia. 9: P684-P685. DOI: 10.1016/J.Jalz.2013.04.348  0.38
2013 Becker J, Rentz D, Pepin L, Sperling R, Johnson K. Amyloid, apolipoprotein E (APOE) and age in relation to longitudinal FDG metabolism and clinical decline in cognitively normal and mildly impaired elderly Alzheimers & Dementia. 9. DOI: 10.1016/J.Jalz.2013.04.143  0.389
2013 Sperling R. Functional MRI as a marker of memory network disruption in early Alzheimer's disease Alzheimers & Dementia. 9: 313. DOI: 10.1016/J.Jalz.2013.04.130  0.422
2013 Mormino E, Vannini P, Amariglio R, Schultz A, Marshall G, Johnson K, Sperling R, Rentz D. O1-04-04: Subjective cognitive concerns, amyloid burden and cognitive reserve Alzheimer's & Dementia. 9: P133-P134. DOI: 10.1016/J.Jalz.2013.04.070  0.357
2013 Rentz D, Hedden T, Mormino E, Amariglio R, Becker J, Schultz A, Marshall G, Sperling R, Johnson K. IC-O2-02: Detecting cognitive evidence of preclinical Alzheimer's disease Alzheimer's & Dementia. 9: P6-P6. DOI: 10.1016/J.Jalz.2013.04.022  0.388
2013 Kinnunen K, Ryan N, Cash D, Leite AB, Finnegan S, Cardoso M, Leung K, Modat M, Benzinger T, Jack C, Marcus D, Raichle M, Thompson P, Ringman J, Ghetti B, ... ... Sperling R, et al. Are early atrophy patterns in autosomal dominant familial Alzheimer's disease gene-dependent? Alzheimers & Dementia. 9. DOI: 10.1016/J.Jalz.2013.04.017  0.328
2013 Sperling R. Sowing the seeds of hope: The potential to slow disease now and prevent dementia in the future Alzheimers & Dementia. 9: 1. DOI: 10.1016/J.Jalz.2013.04.010  0.337
2012 Marshall GA, Amariglio RE, Sperling RA, Rentz DM. Activities of daily living: where do they fit in the diagnosis of Alzheimer's disease? Neurodegenerative Disease Management. 2: 483-491. PMID 23585777 DOI: 10.2217/nmt.12.55  0.378
2012 Hedden T, Mormino EC, Amariglio RE, Younger AP, Schultz AP, Becker JA, Buckner RL, Johnson KA, Sperling RA, Rentz DM. Cognitive profile of amyloid burden and white matter hyperintensities in cognitively normal older adults. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 32: 16233-42. PMID 23152607 DOI: 10.1523/JNEUROSCI.2462-12.2012  0.323
2012 Morris JC, Aisen PS, Bateman RJ, Benzinger TL, Cairns NJ, Fagan AM, Ghetti B, Goate AM, Holtzman DM, Klunk WE, McDade E, Marcus DS, Martins RN, Masters CL, Mayeux R, ... Sperling RA, et al. Developing an international network for Alzheimer research: The Dominantly Inherited Alzheimer Network. Clinical Investigation. 2: 975-984. PMID 23139856 DOI: 10.4155/Cli.12.93  0.331
2012 Reiman EM, Quiroz YT, Fleisher AS, Chen K, Velez-Pardo C, Jimenez-Del-Rio M, Fagan AM, Shah AR, Alvarez S, Arbelaez A, Giraldo M, Acosta-Baena N, Sperling RA, Dickerson B, Stern CE, et al. Brain imaging and fluid biomarker analysis in young adults at genetic risk for autosomal dominant Alzheimer's disease in the presenilin 1 E280A kindred: a case-control study. The Lancet. Neurology. 11: 1048-56. PMID 23137948 DOI: 10.1016/S1474-4422(12)70228-4  0.576
2012 Huijbers W, Vannini P, Sperling RA, C M P, Cabeza R, Daselaar SM. Explaining the encoding/retrieval flip: memory-related deactivations and activations in the posteromedial cortex. Neuropsychologia. 50: 3764-74. PMID 22982484 DOI: 10.1016/J.Neuropsychologia.2012.08.021  0.807
2012 Amariglio RE, Becker JA, Carmasin J, Wadsworth LP, Lorius N, Sullivan C, Maye JE, Gidicsin C, Pepin LC, Sperling RA, Johnson KA, Rentz DM. Subjective cognitive complaints and amyloid burden in cognitively normal older individuals. Neuropsychologia. 50: 2880-6. PMID 22940426 DOI: 10.1016/J.Neuropsychologia.2012.08.011  0.366
2012 Wadsworth LP, Lorius N, Donovan NJ, Locascio JJ, Rentz DM, Johnson KA, Sperling RA, Marshall GA. Neuropsychiatric symptoms and global functional impairment along the Alzheimer's continuum. Dementia and Geriatric Cognitive Disorders. 34: 96-111. PMID 22922821 DOI: 10.1159/000342119  0.353
2012 Chhatwal JP, Sperling RA. Functional MRI of mnemonic networks across the spectrum of normal aging, mild cognitive impairment, and Alzheimer's disease. Journal of Alzheimer's Disease : Jad. 31: S155-67. PMID 22890098 DOI: 10.3233/Jad-2012-120730  0.358
2012 Doraiswamy PM, Sperling RA, Coleman RE, Johnson KA, Reiman EM, Davis MD, Grundman M, Sabbagh MN, Sadowsky CH, Fleisher AS, Carpenter A, Clark CM, Joshi AD, Mintun MA, Skovronsky DM, et al. Amyloid-β assessed by florbetapir F 18 PET and 18-month cognitive decline: a multicenter study. Neurology. 79: 1636-44. PMID 22786606 DOI: 10.1212/Wnl.0B013E3182661F74  0.355
2012 Bateman RJ, Xiong C, Benzinger TL, Fagan AM, Goate A, Fox NC, Marcus DS, Cairns NJ, Xie X, Blazey TM, Holtzman DM, Santacruz A, Buckles V, Oliver A, Moulder K, ... Sperling RA, et al. Clinical and biomarker changes in dominantly inherited Alzheimer's disease. The New England Journal of Medicine. 367: 795-804. PMID 22784036 DOI: 10.1056/Nejmoa1202753  0.313
2012 Amariglio RE, Frishe K, Olson LE, Wadsworth LP, Lorius N, Sperling RA, Rentz DM. Validation of the Face Name Associative Memory Exam in cognitively normal older individuals. Journal of Clinical and Experimental Neuropsychology. 34: 580-7. PMID 22765048 DOI: 10.1080/13803395.2012.666230  0.324
2012 Desikan RS, McEvoy LK, Thompson WK, Holland D, Brewer JB, Aisen PS, Sperling RA, Dale AM. Amyloid-β--associated clinical decline occurs only in the presence of elevated P-tau. Archives of Neurology. 69: 709-13. PMID 22529247 DOI: 10.1001/Archneurol.2011.3354  0.334
2012 McLaren DG, Sreenivasan A, Diamond EL, Mitchell MB, Van Dijk KR, Deluca AN, O'Brien JL, Rentz DM, Sperling RA, Atri A. Tracking cognitive change over 24 weeks with longitudinal functional magnetic resonance imaging in Alzheimer's disease. Neuro-Degenerative Diseases. 9: 176-86. PMID 22456451 DOI: 10.1159/000335876  0.382
2012 Bakken TE, Roddey JC, Djurovic S, Akshoomoff N, Amaral DG, Bloss CS, Casey BJ, Chang L, Ernst TM, Gruen JR, Jernigan TL, Kaufmann WE, Kenet T, Kennedy DN, Kuperman JM, ... ... Sperling RA, et al. Association of common genetic variants in GPCPD1 with scaling of visual cortical surface area in humans. Proceedings of the National Academy of Sciences of the United States of America. 109: 3985-90. PMID 22343285 DOI: 10.1073/Pnas.1105829109  0.698
2012 Sperling R, Salloway S, Brooks DJ, Tampieri D, Barakos J, Fox NC, Raskind M, Sabbagh M, Honig LS, Porsteinsson AP, Lieberburg I, Arrighi HM, Morris KA, Lu Y, Liu E, et al. Amyloid-related imaging abnormalities in patients with Alzheimer's disease treated with bapineuzumab: a retrospective analysis. The Lancet. Neurology. 11: 241-9. PMID 22305802 DOI: 10.1016/S1474-4422(12)70015-7  0.326
2012 Villemagne VL, Klunk WE, Mathis CA, Rowe CC, Brooks DJ, Hyman BT, Ikonomovic MD, Ishii K, Jack CR, Jagust WJ, Johnson KA, Koeppe RA, Lowe VJ, Masters CL, Montine TJ, ... ... Sperling RA, et al. Aβ Imaging: feasible, pertinent, and vital to progress in Alzheimer's disease. European Journal of Nuclear Medicine and Molecular Imaging. 39: 209-19. PMID 22218879 DOI: 10.1007/S00259-011-2045-0  0.469
2012 Sabuncu MR, Buckner RL, Smoller JW, Lee PH, Fischl B, Sperling RA. The association between a polygenic Alzheimer score and cortical thickness in clinically normal subjects. Cerebral Cortex (New York, N.Y. : 1991). 22: 2653-61. PMID 22169231 DOI: 10.1093/Cercor/Bhr348  0.346
2012 Vannini P, Hedden T, Becker JA, Sullivan C, Putcha D, Rentz D, Johnson KA, Sperling RA. Age and amyloid-related alterations in default network habituation to stimulus repetition. Neurobiology of Aging. 33: 1237-52. PMID 21334099 DOI: 10.1016/j.neurobiolaging.2011.01.003  0.398
2012 Marshall G, Lorius N, Gidicsin C, Maye J, Becker JA, Amariglio R, Rentz D, Sperling R, Johnson K. Instrumental Activities of Daily Living Impairment Is Associated with Temporal and Parietal Hypometabolism in Mild Cognitive Impairment (P04.214) Neurology. 78: P04.214-P04.214. DOI: 10.1212/Wnl.78.1_Meetingabstracts.P04.214  0.387
2012 Salloway S, Sperling R, Porsteinsson A, Crans G, Hernandez C, Abushakra S. Responder Analyses from a 78-Week Phase 2 Placebo-Controlled Study of ELND005 (Scyllo-Inositol) in Mild to Moderate (MM) Alzheimer's Disease (AD) (P04.195) Neurology. 78: P04.195-P04.195. DOI: 10.1212/Wnl.78.1_Meetingabstracts.P04.195  0.325
2012 Porsteinsson A, Sperling R, Salloway S, Crans G, Hernandez C, Abushakra S. Responders to ELND005 (Scyllo-Inositol) Demonstrate Clinical and Biomarker Characteristics Consistent with Mild Alzheimer's Disease (AD): Data from a 78-Week Phase 2 Study in Mild to Moderate (M/M) AD (P04.194) Neurology. 78: P04.194-P04.194. DOI: 10.1212/Wnl.78.1_Meetingabstracts.P04.194  0.402
2012 Mckhann GM, Albert MS, Sperling RA. Changing diagnostic concepts of Alzheimer's disease Advances in Biological Psychiatry. 28: 115-121. DOI: 10.1159/000335402  0.45
2012 Sperling R, Downing AC, Salmon D, Rentz D, Siemers E, Sethuraman G, Karlawish J, Johnson K, Donohue M, Aisen P. The A4 trial: Anti-amyloid treatment of asymptomatic Alzheimer's disease Alzheimers & Dementia. 10: 246. DOI: 10.1016/J.Jalz.2014.04.378  0.346
2012 Doraiswamy PM, Sperling R, Coleman E, Johnson K, Fleisher A, Reiman E, Sabbagh M, Sadowsky C, Joshi A, Lu M, Mintun M, Skovronsky D, Pontecorvo M. Prognostic significance of Florbetapir (18F-Florbetapir) PET imaging for future cognitive performance in recently diagnosed MCI: Final results from a 3-year multicenter longitudinal trial Alzheimers & Dementia. 8. DOI: 10.1016/J.Jalz.2013.08.063  0.318
2012 Becker J, Koeppe R, Benzinger T, Jack C, Marcus D, Raichle M, Thompson P, Saykin A, Correia S, Schofield P, Rowe C, Fox N, Brickman A, Ghetti B, Masters C, ... ... Sperling R, et al. FDG metabolism in the DIAN study of autosomal dominant Alzheimer's disease Alzheimers & Dementia. 8. DOI: 10.1016/J.Jalz.2012.05.655  0.344
2012 Chhatwal J, Schultz A, Johnson K, Benzinger T, Jack C, Salloway S, Ringman J, Koeppe R, Marcus D, Thompson P, Saykin A, Correia S, Schofield P, Rowe C, Fox N, ... ... Sperling R, et al. O2-06-01: Disrupted functional connectivity in autosomal dominant Alzheimer's disease: Preliminary findings from the DIAN study Alzheimer's & Dementia. 8: P244-P245. DOI: 10.1016/J.Jalz.2012.05.654  0.367
2012 Sperling R, Roberts S. Disclosure of amyloid status in secondary prevention trials for Alzheimer's disease Alzheimers & Dementia. 8. DOI: 10.1016/J.Jalz.2012.05.2120  0.406
2012 Benzinger T, Blazey T, Ances B, Raichle M, Ances B, Snyder A, Su Y, Marcus D, Ringman J, Thompson P, Ghetti B, Saykin A, Salloway S, Correia S, Johnson K, ... Sperling R, et al. IC-P-128: Progressive white matter abnormalities in autosomal dominant Alzheimer's disease: Results of the DIAN study Alzheimer's & Dementia. 8: P68-P69. DOI: 10.1016/j.jalz.2012.05.1858  0.363
2012 Kinnunen K, Cash D, Leung K, Liang Y, Cardoso M, Modat M, Malone I, Benzinger T, Koeppe R, Jack C, Raichle M, Marcus D, Ringman J, Thompson P, Saykin A, ... ... Sperling R, et al. Brain and hippocampal rates of atrophy in familial Alzheimer's disease mutation carriers: Preliminary findings from the DIAN study Alzheimers & Dementia. 8. DOI: 10.1016/J.Jalz.2012.05.172  0.343
2012 Sperling R. Amyloid-Related Imaging Abnormalities (ARIA) Alzheimers & Dementia. 8: 606. DOI: 10.1016/J.Jalz.2012.05.1624  0.305
2012 Benzinger T, Blazey T, Koeppe R, Jack C, Raichle M, Su Y, Snyder A, Marcus D, Ringman J, Thompson P, Ghetti B, Saykin A, Salloway S, Correia S, Johnson K, Sperling R, et al. Elevated PiB precedes dementia in autosomal dominant Alzheimer's disease: PiB, FDG and atrophy in the DIAN cohort Alzheimers & Dementia. 8. DOI: 10.1016/J.Jalz.2012.05.132  0.42
2012 Donovan N, Wadsworth L, Lorius N, Locascio J, Rentz D, Johnson K, Sperling R, Marshall G. Regional cortical thinning predicts worsening apathy and hallucinations in mild cognitive impairment and mild Alzheimer's disease Alzheimers & Dementia. 8: 26. DOI: 10.1016/J.Jalz.2012.05.071  0.442
2012 Kinnunen K, Cash D, Liang Y, Leung K, Cardoso M, Modat M, Malone I, Yeatman T, Nicholas J, Benzinger T, Koeppe R, Jack C, Raichle M, Marcus D, Ringman J, ... ... Sperling R, et al. Cross-sectional cerebral volumetric differences and associations with estimated time to age-at-onset in familial Alzheimer's disease: Findings from the DIAN study Alzheimers & Dementia. 8: 23. DOI: 10.1016/J.Jalz.2012.05.064  0.431
2012 McLaren D, Sperling R, Atri A. A biomarker signal: Context-dependent hippocampal fMRI connectivity analysis of clinical trial measures in Alzheimer's disease Alzheimers & Dementia. 8: 19. DOI: 10.1016/J.Jalz.2012.05.054  0.384
2012 Cash D, Ridgway G, Ryan N, Kinnunen K, Yeatman T, Malone I, Benzinger T, Koeppe R, Jack C, Raichle M, Marcus D, Ringman J, Thompson P, Saykin A, Salloway S, ... ... Sperling R, et al. A voxel-based morphometry study of volumetric MRI in familial Alzheimer’s disease Alzheimers & Dementia. 8. DOI: 10.1016/J.Jalz.2012.05.052  0.36
2012 Bateman R, Benzinger T, Cairns N, Fagan A, Goate A, Marcus D, Storandt M, Xiong C, Buckles V, Holtzman D, Moulder K, Oliver A, Santacruz A, Fox N, Ghetti B, ... ... Sperling R, et al. Presymptomatic Alzheimer's disease in the Dominantly Inherited Alzheimer's Network (DIAN) Alzheimers & Dementia. 8: 4. DOI: 10.1016/J.Jalz.2012.05.015  0.398
2011 Silverberg NB, Ryan LM, Carrillo MC, Sperling R, Petersen RC, Posner HB, Snyder PJ, Hilsabeck R, Gallagher M, Raber J, Rizzo A, Possin K, King J, Kaye J, Ott BR, et al. Assessment of cognition in early dementia. Alzheimer's & Dementia : the Journal of the Alzheimer's Association. 7: e60-e76. PMID 23559893 DOI: 10.1016/J.Jalz.2011.05.001  0.603
2011 Reiman EM, McKhann GM, Albert MS, Sperling RA, Petersen RC, Blacker D. Clinical impact of updated diagnostic and research criteria for Alzheimer's disease. The Journal of Clinical Psychiatry. 72: e37. PMID 22244033 DOI: 10.4088/Jcp.10087Tx2C  0.511
2011 Holtzman DM, Goate A, Kelly J, Sperling R. Mapping the road forward in Alzheimer's disease. Science Translational Medicine. 3: 114ps48. PMID 22190237 DOI: 10.1126/Scitranslmed.3003529  0.429
2011 Putcha D, Brickhouse M, O'Keefe K, Sullivan C, Rentz D, Marshall G, Dickerson B, Sperling R. Hippocampal hyperactivation associated with cortical thinning in Alzheimer's disease signature regions in non-demented elderly adults. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 31: 17680-8. PMID 22131428 DOI: 10.1523/Jneurosci.4740-11.2011  0.682
2011 Sperling R. Potential of functional MRI as a biomarker in early Alzheimer's disease. Neurobiology of Aging. 32: S37-43. PMID 22078171 DOI: 10.1016/J.Neurobiolaging.2011.09.009  0.448
2011 Reiman EM, McKhann GM, Albert MS, Sperling RA, Petersen RC, Blacker D. Alzheimer's disease: implications of the updated diagnostic and research criteria. The Journal of Clinical Psychiatry. 72: 1190-6. PMID 21951985 DOI: 10.4088/Jcp.10087Co1C  0.45
2011 Salloway S, Sperling R, Keren R, Porsteinsson AP, van Dyck CH, Tariot PN, Gilman S, Arnold D, Abushakra S, Hernandez C, Crans G, Liang E, Quinn G, Bairu M, Pastrak A, et al. A phase 2 randomized trial of ELND005, scyllo-inositol, in mild to moderate Alzheimer disease. Neurology. 77: 1253-62. PMID 21917766 DOI: 10.1212/Wnl.0B013E3182309Fa5  0.345
2011 Sabuncu MR, Desikan RS, Sepulcre J, Yeo BT, Liu H, Schmansky NJ, Reuter M, Weiner MW, Buckner RL, Sperling RA, Fischl B. The dynamics of cortical and hippocampal atrophy in Alzheimer disease. Archives of Neurology. 68: 1040-8. PMID 21825241 DOI: 10.1001/Archneurol.2011.167  0.4
2011 Jack CR, Barkhof F, Bernstein MA, Cantillon M, Cole PE, Decarli C, Dubois B, Duchesne S, Fox NC, Frisoni GB, Hampel H, Hill DL, Johnson K, Mangin JF, Scheltens P, ... ... Sperling R, et al. Steps to standardization and validation of hippocampal volumetry as a biomarker in clinical trials and diagnostic criterion for Alzheimer's disease. Alzheimer's & Dementia : the Journal of the Alzheimer's Association. 7: 474-485.e4. PMID 21784356 DOI: 10.1016/J.Jalz.2011.04.007  0.387
2011 Marshall GA, Olson LE, Frey MT, Maye J, Becker JA, Rentz DM, Sperling RA, Johnson KA. Instrumental activities of daily living impairment is associated with increased amyloid burden. Dementia and Geriatric Cognitive Disorders. 31: 443-50. PMID 21778725 DOI: 10.1159/000329543  0.353
2011 Ewers M, Sperling RA, Klunk WE, Weiner MW, Hampel H. Neuroimaging markers for the prediction and early diagnosis of Alzheimer's disease dementia. Trends in Neurosciences. 34: 430-42. PMID 21696834 DOI: 10.1016/J.Tins.2011.05.005  0.38
2011 Rentz DM, Amariglio RE, Becker JA, Frey M, Olson LE, Frishe K, Carmasin J, Maye JE, Johnson KA, Sperling RA. Face-name associative memory performance is related to amyloid burden in normal elderly. Neuropsychologia. 49: 2776-83. PMID 21689670 DOI: 10.1016/J.Neuropsychologia.2011.06.006  0.366
2011 Marshall GA, Rentz DM, Frey MT, Locascio JJ, Johnson KA, Sperling RA. Executive function and instrumental activities of daily living in mild cognitive impairment and Alzheimer's disease. Alzheimer's & Dementia : the Journal of the Alzheimer's Association. 7: 300-8. PMID 21575871 DOI: 10.1016/j.jalz.2010.04.005  0.37
2011 Atri A, O'Brien JL, Sreenivasan A, Rastegar S, Salisbury S, DeLuca AN, O'Keefe KM, LaViolette PS, Rentz DM, Locascio JJ, Sperling RA. Test-retest reliability of memory task functional magnetic resonance imaging in Alzheimer disease clinical trials. Archives of Neurology. 68: 599-606. PMID 21555634 DOI: 10.1001/Archneurol.2011.94  0.311
2011 Sperling RA, Aisen PS, Beckett LA, Bennett DA, Craft S, Fagan AM, Iwatsubo T, Jack CR, Kaye J, Montine TJ, Park DC, Reiman EM, Rowe CC, Siemers E, Stern Y, et al. Toward defining the preclinical stages of Alzheimer's disease: recommendations from the National Institute on Aging-Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease. Alzheimer's & Dementia : the Journal of the Alzheimer's Association. 7: 280-92. PMID 21514248 DOI: 10.1016/J.Jalz.2011.03.003  0.375
2011 Jack CR, Albert MS, Knopman DS, McKhann GM, Sperling RA, Carrillo MC, Thies B, Phelps CH. Introduction to the recommendations from the National Institute on Aging-Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease. Alzheimer's & Dementia : the Journal of the Alzheimer's Association. 7: 257-62. PMID 21514247 DOI: 10.1016/J.Jalz.2011.03.004  0.523
2011 Dickerson BC, Stoub TR, Shah RC, Sperling RA, Killiany RJ, Albert MS, Hyman BT, Blacker D, Detoledo-Morrell L. Alzheimer-signature MRI biomarker predicts AD dementia in cognitively normal adults. Neurology. 76: 1395-402. PMID 21490323 DOI: 10.1212/Wnl.0B013E3182166E96  0.787
2011 Drzezga A, Becker JA, Van Dijk KR, Sreenivasan A, Talukdar T, Sullivan C, Schultz AP, Sepulcre J, Putcha D, Greve D, Johnson KA, Sperling RA. Neuronal dysfunction and disconnection of cortical hubs in non-demented subjects with elevated amyloid burden. Brain : a Journal of Neurology. 134: 1635-46. PMID 21490054 DOI: 10.1093/brain/awr066  0.465
2011 Becker JA, Hedden T, Carmasin J, Maye J, Rentz DM, Putcha D, Fischl B, Greve DN, Marshall GA, Salloway S, Marks D, Buckner RL, Sperling RA, Johnson KA. Amyloid-β associated cortical thinning in clinically normal elderly. Annals of Neurology. 69: 1032-42. PMID 21437929 DOI: 10.1002/Ana.22333  0.394
2011 Yang W, Lui RL, Gao JH, Chan TF, Yau ST, Sperling RA, Huang X. Independent component analysis-based classification of Alzheimer's disease MRI data. Journal of Alzheimer's Disease : Jad. 24: 775-83. PMID 21321398 DOI: 10.3233/Jad-2011-101371  0.347
2011 Putcha D, O'Keefe K, LaViolette P, O'Brien J, Greve D, Rentz DM, Locascio J, Atri A, Sperling R. Reliability of functional magnetic resonance imaging associative encoding memory paradigms in non-demented elderly adults. Human Brain Mapping. 32: 2027-44. PMID 21259385 DOI: 10.1002/Hbm.21166  0.492
2011 Bateman RJ, Aisen PS, De Strooper B, Fox NC, Lemere CA, Ringman JM, Salloway S, Sperling RA, Windisch M, Xiong C. Autosomal-dominant Alzheimer's disease: a review and proposal for the prevention of Alzheimer's disease. Alzheimer's Research & Therapy. 3: 1. PMID 21211070 DOI: 10.1186/Alzrt59  0.3
2011 Pihlajamäki M, O'Keefe K, O'Brien J, Blacker D, Sperling RA. Failure of repetition suppression and memory encoding in aging and Alzheimer's disease. Brain Imaging and Behavior. 5: 36-44. PMID 21161449 DOI: 10.1007/s11682-010-9110-3  0.398
2011 Becker J, Gidicsin C, Maye J, Sperling R, Johnson K. P4-470: Characterizing biomarker dynamics along the Alzheimer's disease trajectory Alzheimer's & Dementia. 7: e74-e74. DOI: 10.1016/J.Jalz.2011.09.163  0.359
2011 Sperling R, Salloway S, Arrighi M, Morris K, Lu Y, Liu E, Black R, Brashear RH, Grundman M. Revised estimates of incidence and risk factors for amyloid related imaging abnormalities (ARIA) in the phase 2 studies of bapineuzumab for mild-to-moderate Alzheimer's disease Alzheimers & Dementia. 7. DOI: 10.1016/J.Jalz.2011.09.134  0.36
2011 Marshall G, Lorius N, Locascio J, Rentz D, Johnson K, Sperling R. Low CSF Abeta 1-42 is associated with worsening daily functioning in mild cognitive impairment and mild Alzheimer's disease Alzheimers & Dementia. 7. DOI: 10.1016/J.Jalz.2011.05.936  0.447
2011 Wadsworth L, England R, Frishe K, Olson L, Johnson K, Sperling R, Rentz D. Paired associative learning is related to amyloid deposition in normal older individuals. Alzheimers & Dementia. 7. DOI: 10.1016/J.Jalz.2011.05.852  0.31
2011 Maye J, Gidicsin C, Carmasin J, Becker JA, Blacker D, Rentz D, Sperling R, Johnson K. P1-382: Maternal history of dementia is associated with amyloid deposition and brain glucose hypometabolism in cognitively normal and mildly impaired elderly Alzheimer's & Dementia. 7: S234-S235. DOI: 10.1016/J.Jalz.2011.05.663  0.403
2011 Rentz D, Betensky R, Becker A, England R, Maye J, Gidicsin C, Sperling R, Johnson K. P1-341: Amyloid deposition in non-demented elderly predicts longitudinal cognitive decline Alzheimer's & Dementia. 7: S221-S221. DOI: 10.1016/J.Jalz.2011.05.621  0.377
2011 Wadsworth LP, Rentz D, Lorius N, Johnson K, Sperling R, Locascio J, Donvan N, Marshall G. Neuropsychiatric Symptoms are Associated with Current and Future Global Functional Impairment in Mild Cognitive Impairment Alzheimers & Dementia. 7. DOI: 10.1016/J.Jalz.2011.05.456  0.336
2011 Sperling R. Can we detect Alzheimer's disease 10 years before dementia and why would we want to? Alzheimers & Dementia. 7. DOI: 10.1016/J.Jalz.2011.05.2319  0.398
2011 McLaren D, Sperling R, Atri A. fMRI Context-dependent connectivity in Alzheimer's disease Alzheimers & Dementia. 7. DOI: 10.1016/J.Jalz.2011.05.2128  0.414
2011 Porsteinsson A, Sperling R, Salloway S, Keren R, Dyck Cv, Tariot P, Arnold D, Crans G, Hernandez R, Liang E, Bairu M, Cedarbaum J, Pastrak A, Abushakra S. Imaging and cerebrospinal fluid biomarker results of a phase II dose-ranging study of ELND005 (Scyllo-inositol) in mild-to-moderate Alzheimer's disease Alzheimers & Dementia. 7. DOI: 10.1016/J.Jalz.2011.05.2010  0.326
2011 Lorius N, Locascio J, Rentz D, Johnson K, Sperling R, Blacker D, Viswanathan A, Marshall G. Vascular risk factors are associated with cognitive decline in mild cognitive impairment Alzheimers & Dementia. 7. DOI: 10.1016/J.Jalz.2011.05.1693  0.329
2011 Salloway S, Porsteinsson A, Sperling R, Keren R, Dyck Cv, Tariot P, Gilman S, Crans G, Hernandez R, Quinn G, Bairu M, Cedarbaum J, Pastrak A, Abushakra S. Safety and efficacy results of a phase II randomized, placebo-controlled, dose-ranging study of elnd005 (scyllo-inositol) in mild-to-moderate Alzheimer's disease Alzheimers & Dementia. 7. DOI: 10.1016/J.Jalz.2011.05.1371  0.304
2011 Quiroz Y, Sperling R, Lopera F, Fleisher A, Chen K, Tirado V, Munoz C, Langbaum J, Tariot P, Stern C, Reiman E. IC-P-066: Task-dependent fMRI abnormalities in young adults at genetic risk for early-onset Alzheimer's disease Alzheimer's & Dementia. 7: S34-S35. DOI: 10.1016/J.Jalz.2011.05.132  0.371
2011 Vannini P, Hedden T, McLaren D, Maye J, Ward A, Sullivan C, Olson L, Becker J, Johnson K, Sperling R. P2-355: Increased amyloid deposition and parental history of Alzheimer's disease is related to altered default network activity during successful encoding in cognitively normal older adults Alzheimer's & Dementia. 7: S426-S427. DOI: 10.1016/J.Jalz.2011.05.1231  0.442
2011 Dickerson B, Stoub T, Shah R, Sperling R, Killiany R, Albert M, Hyman B, Blacker D, DeToledo-Morrell L. IC-P-040: Alzheimer's signature MRI biomarker predicts likelihood of Alzheimer's dementia in cognitively normal adults Alzheimer's & Dementia. 7: S24-S25. DOI: 10.1016/J.Jalz.2011.05.109  0.759
2011 Sperling R, Bronen R, Greenberg S, Sorensen AG, Salloway S, Gass A, Meadowcroft M, Berman R, Albright C, Coric V, Feldman H. Three cases of apparent Vasogenic Edema (VE) from a phase 2 clinical trial of the gamma secretase Inhibitor BMS-708163 in patients with mild-to-moderate AD Alzheimers & Dementia. 7. DOI: 10.1016/J.Jalz.2011.05.1085  0.334
2011 Feldman H, Coric V, Sperling R, Greenberg S, Bronen R, Sorensen AG, Salloway S, Pachai C, Kaplita S, Meadowcroft M, Albright C, Berman R. Cerebral microbleeds in a phase 2 clinical trial of mild-to-moderate Alzheimer's disease with the gamma secretase inhibitor BMS-708163 Alzheimers & Dementia. 7. DOI: 10.1016/J.Jalz.2011.05.1080  0.354
2011 Quiroz Y, Stern C, Reiman E, Brickhouse M, Moreno S, Henao E, Sperling R, Lopera F, Dickerson B. Cortical signature of alzheimer's disease-related thinning in presymptomatic presenilin-1 mutation carriers Alzheimers & Dementia. 7. DOI: 10.1016/J.Jalz.2011.05.016  0.362
2011 Pihlajamäki M, Sperling RA. Functional MRI in Alzheimer's Disease and Other Dementias The Handbook of Alzheimer's Disease and Other Dementias. 535-556. DOI: 10.1002/9781444344110.ch18  0.317
2010 Desikan RS, Sabuncu MR, Schmansky NJ, Reuter M, Cabral HJ, Hess CP, Weiner MW, Biffi A, Anderson CD, Rosand J, Salat DH, Kemper TL, Dale AM, Sperling RA, Fischl B, et al. Selective disruption of the cerebral neocortex in Alzheimer's disease. Plos One. 5: e12853. PMID 20886094 DOI: 10.1371/Journal.Pone.0012853  0.402
2010 Sperling R, Johnson K. Pro: Can biomarkers be gold standards in Alzheimer's disease? Alzheimer's Research & Therapy. 2: 17. PMID 20587006 DOI: 10.1186/alzrt41  0.359
2010 O'Brien JL, O'Keefe KM, LaViolette PS, DeLuca AN, Blacker D, Dickerson BC, Sperling RA. Longitudinal fMRI in elderly reveals loss of hippocampal activation with clinical decline. Neurology. 74: 1969-76. PMID 20463288 DOI: 10.1212/Wnl.0B013E3181E3966E  0.606
2010 Rentz DM, Locascio JJ, Becker JA, Moran EK, Eng E, Buckner RL, Sperling RA, Johnson KA. Cognition, reserve, and amyloid deposition in normal aging. Annals of Neurology. 67: 353-64. PMID 20373347 DOI: 10.1002/ana.21904  0.353
2010 Wang L, Laviolette P, O'Keefe K, Putcha D, Bakkour A, Van Dijk KR, Pihlajamäki M, Dickerson BC, Sperling RA. Intrinsic connectivity between the hippocampus and posteromedial cortex predicts memory performance in cognitively intact older individuals. Neuroimage. 51: 910-7. PMID 20188183 DOI: 10.1016/J.Neuroimage.2010.02.046  0.556
2010 Wang L, Negreira A, LaViolette P, Bakkour A, Sperling RA, Dickerson BC. Intrinsic interhemispheric hippocampal functional connectivity predicts individual differences in memory performance ability. Hippocampus. 20: 345-51. PMID 20087893 DOI: 10.1002/Hipo.20771  0.509
2010 Sperling RA, Dickerson BC, Pihlajamaki M, Vannini P, LaViolette PS, Vitolo OV, Hedden T, Becker JA, Rentz DM, Selkoe DJ, Johnson KA. Functional alterations in memory networks in early Alzheimer's disease. Neuromolecular Medicine. 12: 27-43. PMID 20069392 DOI: 10.1007/S12017-009-8109-7  0.704
2010 Pihlajamäki M, O' Keefe K, Bertram L, Tanzi RE, Dickerson BC, Blacker D, Albert MS, Sperling RA. Evidence of altered posteromedial cortical FMRI activity in subjects at risk for Alzheimer disease. Alzheimer Disease and Associated Disorders. 24: 28-36. PMID 19571734 DOI: 10.1097/Wad.0B013E3181A785C9  0.698
2009 Salloway S, Sperling R, Gilman S, Fox NC, Blennow K, Raskind M, Sabbagh M, Honig LS, Doody R, van Dyck CH, Mulnard R, Barakos J, Gregg KM, Liu E, Lieberburg I, et al. A phase 2 multiple ascending dose trial of bapineuzumab in mild to moderate Alzheimer disease. Neurology. 73: 2061-70. PMID 19923550 DOI: 10.1212/Wnl.0B013E3181C67808  0.373
2009 Pihlajamäki M, Sperling RA. Functional MRI assessment of task-induced deactivation of the default mode network in Alzheimer's disease and at-risk older individuals. Behavioural Neurology. 21: 77-91. PMID 19847047 DOI: 10.3233/BEN-2009-0231  0.419
2009 Dickerson BC, Sperling RA. Large-scale functional brain network abnormalities in Alzheimer's disease: insights from functional neuroimaging. Behavioural Neurology. 21: 63-75. PMID 19847046 DOI: 10.3233/BEN-2009-0227  0.599
2009 Hedden T, Van Dijk KR, Becker JA, Mehta A, Sperling RA, Johnson KA, Buckner RL. Disruption of functional connectivity in clinically normal older adults harboring amyloid burden. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 29: 12686-94. PMID 19812343 DOI: 10.1523/JNEUROSCI.3189-09.2009  0.335
2009 Sperling RA, Laviolette PS, O'Keefe K, O'Brien J, Rentz DM, Pihlajamaki M, Marshall G, Hyman BT, Selkoe DJ, Hedden T, Buckner RL, Becker JA, Johnson KA. Amyloid deposition is associated with impaired default network function in older persons without dementia. Neuron. 63: 178-88. PMID 19640477 DOI: 10.1016/J.Neuron.2009.07.003  0.58
2009 Carrillo MC, Blackwell A, Hampel H, Lindborg J, Sperling R, Schenk D, Sevigny JJ, Ferris S, Bennett DA, Craft S, Hsu T, Klunk W. Early risk assessment for Alzheimer's disease. Alzheimer's & Dementia : the Journal of the Alzheimer's Association. 5: 182-96. PMID 19328456 DOI: 10.1016/J.Jalz.2009.01.019  0.38
2009 Chua EF, Schacter DL, Sperling RA. Neural basis for recognition confidence in younger and older adults. Psychology and Aging. 24: 139-53. PMID 19290745 DOI: 10.1037/A0014029  0.692
2009 Buckner RL, Sepulcre J, Talukdar T, Krienen FM, Liu H, Hedden T, Andrews-Hanna JR, Sperling RA, Johnson KA. Cortical hubs revealed by intrinsic functional connectivity: mapping, assessment of stability, and relation to Alzheimer's disease. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 29: 1860-73. PMID 19211893 DOI: 10.1523/Jneurosci.5062-08.2009  0.326
2009 Chua EF, Schacter DL, Sperling RA. Neural correlates of metamemory: a comparison of feeling-of-knowing and retrospective confidence judgments. Journal of Cognitive Neuroscience. 21: 1751-65. PMID 18823230 DOI: 10.1162/Jocn.2009.21123  0.702
2009 Dickerson BC, Bakkour A, Salat DH, Feczko E, Pacheco J, Greve DN, Grodstein F, Wright CI, Blacker D, Rosas HD, Sperling RA, Atri A, Growdon JH, Hyman BT, Morris JC, et al. The cortical signature of Alzheimer's disease: regionally specific cortical thinning relates to symptom severity in very mild to mild AD dementia and is detectable in asymptomatic amyloid-positive individuals. Cerebral Cortex (New York, N.Y. : 1991). 19: 497-510. PMID 18632739 DOI: 10.1093/Cercor/Bhn113  0.568
2009 Wang L, laViolette P, O'Keefe K, Putcha D, Hamdi I, Vannini P, Dijk KV, Bakkour A, Sreenivasan A, Atri A, Dickerson B, Sperling R. Intrinsic Connectivity of the Hippocampus and Precuneus/Posterior Cingulate Cortex Predicts Memory Performance in Cognitively Intact Older Individuals Neuroimage. 47. DOI: 10.1016/S1053-8119(09)71494-6  0.591
2009 Putcha D, O'Keefe K, LaViolette P, Hamdi I, O'Brien J, Atri A, Sperling R. Test-Retest of fMRI Activity in Hippocampus and Default Network in Non-demented Elderly Subjects. Neuroimage. 47. DOI: 10.1016/S1053-8119(09)70696-2  0.32
2009 Atri A, Locascio J, Sperling R. Optimizing FMRI test-retest reliability and power estimates for Alzheimer's disease early-phase studies: Modeling decline and leveraging network properties Alzheimers & Dementia. 5: 373. DOI: 10.1016/J.Jalz.2009.04.1175  0.324
2009 Raskind M, Liang E, Sperling R, Boxer A, Ross J, Brody M, Garzone P, Raje S, Black R, Grundman M. Pharmacokinetics and pharmacodynamics of bapineuzumab following multiple intravenous infusions in patients with mild-to-moderate Alzheimer's disease Alzheimers & Dementia. 5. DOI: 10.1016/J.Jalz.2009.04.1019  0.37
2009 Sperling R, Johnson K, Pontecorvo MJ, Safirstein B, Farmer M, Holub R, Korn R, Spicer K, Doraiswamy M, Reiman EM, Joshi A, Saha K, Flitter M, Clark CM, Skovronsky DM. P1-084: PET imaging of β-amyloid with florpiramine F18 (18F-AV-45): Preliminary results from a phase II study of cognitively normal elderly subjects, individuals with mild cognitive impairment, and patients with a clinical diagnosis of Alzheimer's disease Alzheimer's & Dementia. 5: P197-P197. DOI: 10.1016/J.Jalz.2009.04.088  0.398
2008 Pihlajamäki M, DePeau KM, Blacker D, Sperling RA. Impaired medial temporal repetition suppression is related to failure of parietal deactivation in Alzheimer disease. The American Journal of Geriatric Psychiatry : Official Journal of the American Association For Geriatric Psychiatry. 16: 283-92. PMID 18378553 DOI: 10.1097/JGP.0b013e318162a0a9  0.373
2008 Miller SL, Celone K, DePeau K, Diamond E, Dickerson BC, Rentz D, Pihlajamäki M, Sperling RA. Age-related memory impairment associated with loss of parietal deactivation but preserved hippocampal activation. Proceedings of the National Academy of Sciences of the United States of America. 105: 2181-6. PMID 18238903 DOI: 10.1073/Pnas.0706818105  0.809
2008 Dickerson BC, Sperling RA. Functional abnormalities of the medial temporal lobe memory system in mild cognitive impairment and Alzheimer's disease: insights from functional MRI studies. Neuropsychologia. 46: 1624-35. PMID 18206188 DOI: 10.1016/j.neuropsychologia.2007.11.030  0.598
2008 Miller SL, Fenstermacher E, Bates J, Blacker D, Sperling RA, Dickerson BC. Hippocampal activation in adults with mild cognitive impairment predicts subsequent cognitive decline. Journal of Neurology, Neurosurgery, and Psychiatry. 79: 630-5. PMID 17846109 DOI: 10.1136/jnnp.2007.124149  0.571
2008 Pihlajamäki M, Sperling RA. fMRI: Use in early Alzheimer's disease and in clinical trials Future Neurology. 3: 409-421. DOI: 10.2217/14796708.3.4.409  0.421
2008 Sperling R, O'Brien J, O'Keefe K, DeLuca A, LaViolette P, Pihlajamaki M, Johnson K, Blacker D, Dickerson B. P1-295: Longitudinal functional MRI demonstrates loss of hippocampal activation associated with clinical decline in nondemented older subjects Alzheimer's & Dementia. 4: T305-T305. DOI: 10.1016/J.Jalz.2008.05.885  0.561
2008 Becker JA, Carmasin J, Fischl B, Greve D, DeLuca A, LaViolette P, O'Brien J, O'Keefe K, Fischman A, Rentz D, Sperling R, Johnson K. P1-221: Amyloid deposition related to cortical thinning Alzheimers & Dementia. 4. DOI: 10.1016/J.Jalz.2008.05.810  0.331
2008 Sperling R, O'Brien J, O'Keefe K, DeLuca A, LaViolette P, Pihlajamaki M, Johnson K, Blacker D, Dickerson B. IC-P2-139: Longitudinal fMRI demonstrates loss of hippocampal function associated with clinical decline in non-demented older subjects Alzheimer's & Dementia. 4: T62-T62. DOI: 10.1016/J.Jalz.2008.05.2593  0.615
2008 Sperling R. S1-01-06: Functional magnetic resonance imaging in early Alzheimer's disease Alzheimers & Dementia. 4. DOI: 10.1016/J.Jalz.2008.05.188  0.343
2007 Dickerson BC, Sperling RA, Hyman BT, Albert MS, Blacker D. Clinical prediction of Alzheimer disease dementia across the spectrum of mild cognitive impairment. Archives of General Psychiatry. 64: 1443-50. PMID 18056553 DOI: 10.1001/Archpsyc.64.12.1443  0.662
2007 Diamond EL, Miller S, Dickerson BC, Atri A, DePeau K, Fenstermacher E, Pihlajamäki M, Celone K, Salisbury S, Gregas M, Rentz D, Sperling RA. Relationship of fMRI activation to clinical trial memory measures in Alzheimer disease. Neurology. 69: 1331-41. PMID 17893294 DOI: 10.1212/01.Wnl.0000277292.37292.69  0.832
2007 Rentz DM, Huh TJ, Sardinha LM, Moran EK, Becker JA, Daffner KR, Sperling RA, Johnson KA. Intelligence quotient-adjusted memory impairment is associated with abnormal single photon emission computed tomography perfusion. Journal of the International Neuropsychological Society : Jins. 13: 821-31. PMID 17697413 DOI: 10.1017/S1355617707071056  0.662
2007 Dickerson BC, Miller SL, Greve DN, Dale AM, Albert MS, Schacter DL, Sperling RA. Prefrontal-hippocampal-fusiform activity during encoding predicts intraindividual differences in free recall ability: an event-related functional-anatomic MRI study. Hippocampus. 17: 1060-70. PMID 17604356 DOI: 10.1002/Hipo.20338  0.609
2007 Chua EF, Schacter DL, Rand-Giovannetti E, Sperling RA. Evidence for a specific role of the anterior hippocampal region in successful associative encoding. Hippocampus. 17: 1071-80. PMID 17604351 DOI: 10.1002/Hipo.20340  0.704
2007 Sperling R. Functional MRI studies of associative encoding in normal aging, mild cognitive impairment, and Alzheimer's disease. Annals of the New York Academy of Sciences. 1097: 146-55. PMID 17413017 DOI: 10.1196/Annals.1379.009  0.559
2007 Chappell AS, Gonzales C, Williams J, Witte MM, Mohs RC, Sperling R. AMPA potentiator treatment of cognitive deficits in Alzheimer disease. Neurology. 68: 1008-12. PMID 17389305 DOI: 10.1212/01.Wnl.0000260240.46070.7C  0.35
2007 Sperling R, LaViolette P, White E, Becker JA, Moran E, Gregas M, Klunk W, Mathis C, Price J, Fischman A, Selkoe D, Rentz D, Johnson K. O1-05-01: Cortical amyloid deposition related to failure of hippocampal activation Alzheimers & Dementia. 3. DOI: 10.1016/J.Jalz.2007.04.068  0.485
2006 Celone KA, Calhoun VD, Dickerson BC, Atri A, Chua EF, Miller SL, DePeau K, Rentz DM, Selkoe DJ, Blacker D, Albert MS, Sperling RA. Alterations in memory networks in mild cognitive impairment and Alzheimer's disease: an independent component analysis. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 26: 10222-31. PMID 17021177 DOI: 10.1523/Jneurosci.2250-06.2006  0.833
2006 Rentz DM, Sardinha LM, Huh TJ, Searl MM, Daffner KR, Sperling RA. IQ-based norms for highly intelligent adults. The Clinical Neuropsychologist. 20: 637-48. PMID 16980251 DOI: 10.1080/13854040500477498  0.593
2006 Chua EF, Schacter DL, Rand-Giovannetti E, Sperling RA. Understanding metamemory: neural correlates of the cognitive process and subjective level of confidence in recognition memory. Neuroimage. 29: 1150-60. PMID 16303318 DOI: 10.1016/J.Neuroimage.2005.09.058  0.713
2006 Rand-Giovannetti E, Chua EF, Driscoll AE, Schacter DL, Albert MS, Sperling RA. Hippocampal and neocortical activation during repetitive encoding in older persons. Neurobiology of Aging. 27: 173-82. PMID 16298252 DOI: 10.1016/J.Neurobiolaging.2004.12.013  0.764
2006 Quiroz YT, Sperling RA, Lopera F, Baena A, Alvarez S, Guzman-Velez E, Pardilla-Delgado E, Arboleda-Velasquez J, Gatchel JR, Fuller J, Artola A, Schultz AP, Chen K, Tariot PN, Reiman EM, et al. P4-299: TAU ACCUMULATION IN THE ENTORHINAL CORTEX AND PRECUNEUS IS ASSOCIATED WITH CORTICAL AMYLOID-BETA BURDEN, AGE AND WORSE MEMORY PERFORMANCE IN PRECLINICAL AUTOSOMAL DOMINANT ALZHEIMER'S DISEASE Alzheimer's & Dementia. 14: P1567-P1567. DOI: 10.1016/J.Jalz.2018.07.121  0.347
2006 Lim Y, Maruff P, Masters CL, Sperling RA, Johnson KA, Mormino BC. P4-118: AV1451 TAU PET, BUT NOT CSF TAU, IS RELATED TO MEMORY DECLINE IN PRECLINICAL AND PRODROMAL ALZHEIMER'S DISEASE Alzheimer's & Dementia. 14: P1484-P1484. DOI: 10.1016/j.jalz.2018.06.2522  0.335
2006 Sanchez JS, Sperling RA, Lopera F, Augustinack J, Becker A, Jacobs HI, Jin D, Katz S, Luner E, Moody K, Price JC, Guzman-Velez E, Baena A, Pardilla-Delgado E, Chen K, et al. IC-P-215: TAU ACCUMULATION IN RHINAL CORTEX IS ASSOCIATED WITH MEMORY PERFORMANCE IN NON-DEMENTED YOUNG ADULTS WITH AUTOSOMAL DOMINANT ALZHEIMER'S DISEASE Alzheimer's & Dementia. 14: P176-P177. DOI: 10.1016/J.Jalz.2018.06.2282  0.348
2006 Hanseeuw BJ, Lopera F, Sperling RA, Norton D, Guzman-Velez E, Baena A, Schultz AP, Gatchel JR, Chen K, Reiman EM, Johnson KA, Quiroz YT. IC-P-140: TAU ACCUMULATION AND MEMORY DECLINE ARE MORE CLOSELY RELATED TO STRIATAL THAN CORTICAL AMYLOIDOSIS IN INDIVIDUALS WITH EARLY-ONSET AUTOSOMAL DOMINANT ALZHEIMER'S DISEASE Alzheimer's & Dementia. 14: P117-P117. DOI: 10.1016/J.Jalz.2018.06.2206  0.35
2006 Sanchez JS, Sperling RA, Lopera F, Augustinack J, Becker A, Jacobs HI, Jin D, Katz S, Luner E, Moody K, Price JC, Guzman-Velez E, Baena A, Pardilla-Delgado E, Chen K, et al. P2-452: TAU ACCUMULATION IN RHINAL CORTEX IS ASSOCIATED WITH MEMORY PERFORMANCE IN NONDEMENTED YOUNG ADULTS WITH AUTOSOMAL DOMINANT ALZHEIMER'S DISEASE Alzheimer's & Dementia. 14: P892-P892. DOI: 10.1016/j.jalz.2018.06.1145  0.357
2006 Dickerson BC, Hevelone N, Sperling RA, Albert MS, Blacker D. P2-073: Prediction of cognitive decline among very mild MCI cases Alzheimer's & Dementia. 2: S254-S254. DOI: 10.1016/J.Jalz.2006.05.910  0.582
2006 Pihlajamaki M, Miller SM, DePeau KM, Celone KA, Bertram L, Tanzi RE, Dickerson BC, Albert MS, Blacker D, Sperling RA. O4-01-02: The effect of APOE-4 on fMRI deactivation in older controls, MCI subjects and AD patients Alzheimer's & Dementia. 2: S74-S75. DOI: 10.1016/J.Jalz.2006.05.292  0.8
2006 Sperling R, Depeau K, Miller S, Chua E, Rentz D, Dickerson B, Atri A, Selkoe D, Johnson K, Calhoun V, Albert M, Celone K. Ic-101-05 Alzheimers & Dementia. 2. DOI: 10.1016/J.Jalz.2006.05.2344  0.734
2006 DePeau KM, Pihlajamaki M, Diamond EL, Miller SM, Chua EF, Dickerson BC, Albert MS, Blacker D, Sperling RA. IC-P-086: Failure of hippocampal habituation in mild cognitive impairment and Alzheimer's disease Alzheimer's & Dementia. 2: S687-S688. DOI: 10.1016/J.Jalz.2006.05.2291  0.756
2006 Pihlajamaki M, Miller SM, DePeau KM, Celone KA, Bertram L, Tanzi RE, Dickerson BC, Albert MS, Blacker D, Sperling RA. IC-P-071: The effect of APOE-4 on fMRI deactivation in older controls, MCI subjects and AD patients Alzheimer's & Dementia. 2: S681-S681. DOI: 10.1016/J.Jalz.2006.05.2276  0.805
2006 Johnson KA, Pollen D, Rentz D, Moran E, Becker JA, Moonis M, Swearer J, Hyman B, Selkoe D, Sperling R, DeKosky S, Matthis C, Klunk W, Fischman A. IC-103-03: Amyloid deposition in presymptomatic familial Alzheimer's disease Alzheimer's & Dementia. 2: S653-S653. DOI: 10.1016/J.Jalz.2006.05.2198  0.525
2006 DePeau KM, Pihlajamaki M, Diamond EL, Miller SM, Chua EF, Dickerson BC, Albert MS, Blacker D, Sperling RA. P2-381: Failure of hippocampal habituation in mild cognitive impairment and Alzheimer's disease Alzheimer's & Dementia. 2: S357-S358. DOI: 10.1016/j.jalz.2006.05.1221  0.318
2006 Miller SL, Bates J, Blacker D, Sperling R, Dickerson BC. IC-P-081: Hippocampal activation in MCI predicts subsequent cognitive decline Alzheimer's & Dementia. 2: S685-S686. DOI: 10.1016/J.Jalz.2006.05.1202  0.558
2006 Sperling R, Depeau K, Miller S, Chua E, Dorene R, Dickerson B, Atri A, Selkoe D, Albert M, Calhoun V, Celone K. P2-302: FMRI alterations medial temporal and neocortical networks in MCI and AD Alzheimer's & Dementia. 2: S328-S329. DOI: 10.1016/J.Jalz.2006.05.1142  0.793
2006 Johnson KA, Pollen D, Rentz D, Moran E, Becker JA, Moonis M, Swearer J, Hyman B, Selkoe D, Sperling R, DeKosky S, Matthis C, Klunk W, Fischman A. P2-268: Amyloid deposition in presymptomatic familial Alzheimer's disease Alzheimer's & Dementia. 2: S317-S317. DOI: 10.1016/J.Jalz.2006.05.1107  0.529
2006 Dickerson BC, Murthi S, Fenstermacher E, Sperling RA, Blacker D, Csernansky JG, Wang L. P2-257: Hippocampal shape deformities and functional hyperactivation in MCI Alzheimer's & Dementia. 2: S312-S312. DOI: 10.1016/j.jalz.2006.05.1096  0.45
2006 Dickerson BC, Murthi S, Fenstermacher E, Sperling RA, Blacker D, Csernansky JG, Wang L. IC-P-077: Hippocampal shape deformities and functional hyperactivation in MCI Alzheimer's & Dementia. 2: S683-S684. DOI: 10.1016/J.Jalz.2006.05.1096  0.449
2005 Dickerson BC, Salat DH, Greve DN, Chua EF, Rand-Giovannetti E, Rentz DM, Bertram L, Mullin K, Tanzi RE, Blacker D, Albert MS, Sperling RA. Increased hippocampal activation in mild cognitive impairment compared to normal aging and AD. Neurology. 65: 404-11. PMID 16087905 DOI: 10.1212/01.Wnl.0000171450.97464.49  0.82
2005 Dickerson BC, Sperling RA. Neuroimaging biomarkers for clinical trials of disease-modifying therapies in Alzheimer's disease. Neurorx : the Journal of the American Society For Experimental Neurotherapeutics. 2: 348-60. PMID 15897955 DOI: 10.1602/neurorx.2.2.348  0.542
2005 Dickerson BC, Salat DH, Greve DN, Albert MS, Blacker D, Sperling RA. [P-095]: An fMRI investigation of memory-related medial temporal lobe activation in mild cognitive impairment prior to dementia Alzheimer's & Dementia. 1: S38-S38. DOI: 10.1016/J.Jalz.2005.06.169  0.649
2005 Sperling R. fMRI features of AD: Distinguishing Alzheimer’s disease from normal aging and other dementias with fMRI Alzheimers & Dementia. 1. DOI: 10.1016/J.Jalz.2005.06.048  0.411
2004 Chua EF, Rand-Giovannetti E, Schacter DL, Albert MS, Sperling RA. Dissociating confidence and accuracy: functional magnetic resonance imaging shows origins of the subjective memory experience. Journal of Cognitive Neuroscience. 16: 1131-42. PMID 15453969 DOI: 10.1162/0898929041920568  0.742
2004 Dickerson BC, Salat DH, Bates JF, Atiya M, Killiany RJ, Greve DN, Dale AM, Stern CE, Blacker D, Albert MS, Sperling RA. Medial temporal lobe function and structure in mild cognitive impairment. Annals of Neurology. 56: 27-35. PMID 15236399 DOI: 10.1002/Ana.20163  0.675
2004 Rentz DM, Huh TJ, Faust RR, Budson AE, Scinto LF, Sperling RA, Daffner KR. Use of IQ-adjusted norms to predict progressive cognitive decline in highly intelligent older individuals. Neuropsychology. 18: 38-49. PMID 14744186 DOI: 10.1037/0894-4105.18.1.38  0.661
2004 Lange N, Lake S, Sperling R, Brown J, Routledge C, Albert M, Heckers S. Two macroscopic and microscopic brain imaging studies of human hippocampus in early Alzheimer's disease and schizophrenia research. Statistics in Medicine. 23: 327-50. PMID 14716733 DOI: 10.1002/Sim.1720  0.537
2004 Sperling R, Dickerson B, Rand-Giovannetti E, Chua EF, Driscoll AE, Rentz D, Blacker D, Albert MS. P3-100 Increased medial temporal lobe FMRI activation in questionable AD compared to normal aging Neurobiology of Aging. 25: S383. DOI: 10.1016/S0197-4580(04)81252-1  0.792
2004 Dickerson BC, Salat DH, Bates JF, Atiya M, Killiany RJ, Greve DN, Dale AM, Stern CE, Blacker D, Albert MS, Sperling RA. P2-165 Functional and structural MRI in questionable AD: relationships to clinical impairment and future decline Neurobiology of Aging. 25: S272-S273. DOI: 10.1016/S0197-4580(04)80912-6  0.627
2003 Sperling R, Chua E, Cocchiarella A, Rand-Giovannetti E, Poldrack R, Schacter DL, Albert M. Putting names to faces: successful encoding of associative memories activates the anterior hippocampal formation. Neuroimage. 20: 1400-10. PMID 14568509 DOI: 10.1016/S1053-8119(03)00391-4  0.739
2003 Monsonego A, Zota V, Karni A, Krieger JI, Bar-Or A, Bitan G, Budson AE, Sperling R, Selkoe DJ, Weiner HL. Increased T cell reactivity to amyloid beta protein in older humans and patients with Alzheimer disease. The Journal of Clinical Investigation. 112: 415-22. PMID 12897209 DOI: 10.1172/Jci18104  0.559
2003 Sperling RA, Bates JF, Chua EF, Cocchiarella AJ, Rentz DM, Rosen BR, Schacter DL, Albert MS. fMRI studies of associative encoding in young and elderly controls and mild Alzheimer's disease. Journal of Neurology, Neurosurgery, and Psychiatry. 74: 44-50. PMID 12486265 DOI: 10.1136/Jnnp.74.1.44  0.764
2002 Budson AE, Michalska KJ, Rentz DM, Joubert CC, Daffner KR, Schacter DL, Sperling RA. Use of a false recognition paradigm in an Alzheimer's disease clinical trial: a pilot study. American Journal of Alzheimer's Disease and Other Dementias. 17: 93-100. PMID 11954675 DOI: 10.1177/153331750201700204  0.629
2002 Sperling R, Greve D, Dale A, Killiany R, Holmes J, Rosas HD, Cocchiarella A, Firth P, Rosen B, Lake S, Lange N, Routledge C, Albert M. Functional MRI detection of pharmacologically induced memory impairment. Proceedings of the National Academy of Sciences of the United States of America. 99: 455-60. PMID 11756667 DOI: 10.1073/Pnas.012467899  0.559
2001 Sperling RA, Bates JF, Cocchiarella AJ, Schacter DL, Rosen BR, Albert MS. Encoding novel face-name associations: a functional MRI study. Human Brain Mapping. 14: 129-39. PMID 11559958 DOI: 10.1002/Hbm.1047  0.463
2001 Johnson KA, Lopera F, Jones K, Becker A, Sperling R, Hilson J, Londono J, Siegert I, Arcos M, Moreno S, Madrigal L, Ossa J, Pineda N, Ardila A, Roselli M, et al. Presenilin-1-associated abnormalities in regional cerebral perfusion. Neurology. 56: 1545-51. PMID 11402113 DOI: 10.1212/Wnl.56.11.1545  0.523
2001 Sperling RA, Guttmann CR, Hohol MJ, Warfield SK, Jakab M, Parente M, Diamond EL, Daffner KR, Olek MJ, Orav EJ, Kikinis R, Jolesz FA, Weiner HL. Regional magnetic resonance imaging lesion burden and cognitive function in multiple sclerosis: a longitudinal study. Archives of Neurology. 58: 115-21. PMID 11176944 DOI: 10.1001/Archneur.58.1.115  0.552
2001 Sperling R, Greve D, Dale A, Killiany R, Rosen B, Holmes J, Rosas H, Cocchiarella A, Firth P, Lange N, Routledge C, Albert M. Effects of lorazepam and scopolamine on encoding face-name associations: A pharmacologic fMRI trial Neuroimage. 13: 743. DOI: 10.1016/S1053-8119(01)92085-3  0.544
2000 Greenberg SM, Tennis MK, Brown LB, Gomez-Isla T, Hayden DL, Schoenfeld DA, Walsh KL, Corwin C, Daffner KR, Friedman P, Meadows ME, Sperling RA, Growdon JH. Donepezil therapy in clinical practice: a randomized crossover study. Archives of Neurology. 57: 94-9. PMID 10634454 DOI: 10.1001/Archneur.57.1.94  0.605
1996 Sandson TA, O'Connor M, Sperling RA, Edelman RR, Warach S. Noninvasive perfusion MRI in Alzheimer's disease: a preliminary report. Neurology. 47: 1339-42. PMID 8909457 DOI: 10.1212/WNL.47.5.1339  0.359
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