Tiago Fleming Outeiro, Ph.D. - Publications

Neuroscience Unit, Institute of Molecular Medicine University of Lisbon, Lisboa, Lisboa, Portugal 
models of neurodegenerative disease, sreening

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Year Citation  Score
2016 Guerreiro PS, Coelho JE, Sousa-Lima I, Macedo P, Lopes LV, Outeiro TF, Pais TF. Mutant A53T α-Synuclein Improves Rotarod Performance Before Motor Deficits and Affects Metabolic Pathways. Neuromolecular Medicine. PMID 27535567 DOI: 10.1007/s12017-016-8435-5  0.32
2016 Batalha VL, Ferreira DG, Coelho JE, Valadas JS, Gomes R, Temido-Ferreira M, Shmidt T, Baqi Y, Buée L, Müller CE, Hamdane M, Outeiro TF, Bader M, Meijsing SH, Sadri-Vakili G, et al. The caffeine-binding adenosine A2A receptor induces age-like HPA-axis dysfunction by targeting glucocorticoid receptor function. Scientific Reports. 6: 31493. PMID 27510168 DOI: 10.1038/srep31493  0.32
2016 Gonçalves SA, Macedo D, Raquel H, Simões PD, Giorgini F, Ramalho JS, Barral DC, Ferreira Moita L, Outeiro TF. shRNA-Based Screen Identifies Endocytic Recycling Pathway Components That Act as Genetic Modifiers of Alpha-Synuclein Aggregation, Secretion and Toxicity. Plos Genetics. 12: e1005995. PMID 27123591 DOI: 10.1371/journal.pgen.1005995  0.32
2016 Oliveira AO, Osmand A, Outeiro TF, Muchowski PJ, Finkbeiner S. αB-Crystallin over-expression in astrocytes modulates the phenotype of the BACHD mouse model of Huntington's disease. Human Molecular Genetics. PMID 26920069 DOI: 10.1093/hmg/ddw028  0.32
2015 Vreja IC, Nikić I, Göttfert F, Bates M, Kröhnert K, Outeiro TF, Hell SW, Lemke EA, Rizzoli SO. Super-resolution Microscopy of Clickable Amino Acids Reveals the Effects of Fluorescent Protein Tagging on Protein Assemblies. Acs Nano. PMID 26498474 DOI: 10.1021/acsnano.5b04434  0.32
2015 Moree B, Yin G, Lázaro DF, Munari F, Strohäker T, Giller K, Becker S, Outeiro TF, Zweckstetter M, Salafsky J. Small Molecules Detected by Second-Harmonic Generation Modulate the Conformation of Monomeric α-Synuclein and Reduce its Aggregation in Cells. The Journal of Biological Chemistry. PMID 26396193 DOI: 10.1074/jbc.M114.636027  0.32
2015 Dučić T, Carboni E, Lai B, Chen S, Michalke B, Lázaro DF, Outeiro TF, Bähr M, Barski E, Lingor P. Alpha-Synuclein Regulates Neuronal Levels of Manganese and Calcium. Acs Chemical Neuroscience. PMID 26284970 DOI: 10.1021/acschemneuro.5b00093  0.32
2015 Villar-Piqué A, da Fonseca TL, Outeiro TF. Structure, function and toxicity of alpha-synuclein: the Bermuda triangle in synucleinopathies. Journal of Neurochemistry. PMID 26190401 DOI: 10.1111/jnc.13249  0.32
2015 Guerreiro PS, Gerhardt E, Lopes da Fonseca T, Bähr M, Outeiro TF, Eckermann K. LRRK2 Promotes Tau Accumulation, Aggregation and Release. Molecular Neurobiology. PMID 26014385 DOI: 10.1007/s12035-015-9209-z  0.32
2015 Nunes P, Morais GR, Palma E, Silva F, Oliveira MC, Ferreira VF, Mendes F, Gano L, Vicente Miranda H, Outeiro TF, Santos I, Paulo A. Isostructural Re(I)/(99m)Tc(I) tricarbonyl complexes for cancer theranostics. Organic & Biomolecular Chemistry. 13: 5182-94. PMID 25849043 DOI: 10.1039/c5ob00124b  0.32
2015 Mbefo MK, Fares MB, Paleologou K, Oueslati A, Yin G, Tenreiro S, Pinto M, Outeiro T, Zweckstetter M, Masliah E, Lashuel HA. Parkinson disease mutant E46K enhances α-synuclein phosphorylation in mammalian cell lines, in yeast, and in vivo. The Journal of Biological Chemistry. 290: 9412-27. PMID 25657004 DOI: 10.1074/jbc.M114.610774  0.32
2015 Chen X, Wales P, Quinti L, Zuo F, Moniot S, Herisson F, Rauf NA, Wang H, Silverman RB, Ayata C, Maxwell MM, Steegborn C, Schwarzschild MA, Outeiro TF, Kazantsev AG. The sirtuin-2 inhibitor AK7 is neuroprotective in models of Parkinson's disease but not amyotrophic lateral sclerosis and cerebral ischemia. Plos One. 10: e0116919. PMID 25608039 DOI: 10.1371/journal.pone.0116919  0.32
2015 Poças GM, Branco-Santos J, Herrera F, Outeiro TF, Domingos PM. α-Synuclein modifies mutant huntingtin aggregation and neurotoxicity in Drosophila. Human Molecular Genetics. 24: 1898-907. PMID 25452431 DOI: 10.1093/hmg/ddu606  0.32
2015 Macedo D, Tavares L, McDougall GJ, Vicente Miranda H, Stewart D, Ferreira RB, Tenreiro S, Outeiro TF, Santos CN. (Poly)phenols protect from α-synuclein toxicity by reducing oxidative stress and promoting autophagy. Human Molecular Genetics. 24: 1717-32. PMID 25432533 DOI: 10.1093/hmg/ddu585  0.32
2015 Breda C, Nugent ML, Estranero JG, Kyriacou CP, Outeiro TF, Steinert JR, Giorgini F. Rab11 modulates α-synuclein-mediated defects in synaptic transmission and behaviour. Human Molecular Genetics. 24: 1077-91. PMID 25305083 DOI: 10.1093/hmg/ddu521  0.32
2015 Blum D, Herrera F, Francelle L, Mendes T, Basquin M, Obriot H, Demeyer D, Sergeant N, Gerhardt E, Brouillet E, Buée L, Outeiro TF. Mutant huntingtin alters Tau phosphorylation and subcellular distribution. Human Molecular Genetics. 24: 76-85. PMID 25143394 DOI: 10.1093/hmg/ddu421  0.32
2015 Morais GR, Palma E, Marques F, Gano L, Oliveira MC, Abrunhosa A, Miranda HV, Outeiro TF, Santos I, Paulo A. Synthesis and Biological Evaluation of Novel 2-Aryl Benzimidazoles as Chemotherapeutic Agents Journal of Heterocyclic Chemistry. DOI: 10.1002/jhet.2575  0.32
2014 Fonseca-Ornelas L, Eisbach SE, Paulat M, Giller K, Fernández CO, Outeiro TF, Becker S, Zweckstetter M. Small molecule-mediated stabilization of vesicle-associated helical α-synuclein inhibits pathogenic misfolding and aggregation. Nature Communications. 5: 5857. PMID 25524885 DOI: 10.1038/ncomms6857  0.32
2014 Poehler AM, Xiang W, Spitzer P, May VE, Meixner H, Rockenstein E, Chutna O, Outeiro TF, Winkler J, Masliah E, Klucken J. Autophagy modulates SNCA/α-synuclein release, thereby generating a hostile microenvironment. Autophagy. 10: 2171-92. PMID 25484190 DOI: 10.4161/auto.36436  0.32
2014 Lázaro DF, Rodrigues EF, Langohr R, Shahpasandzadeh H, Ribeiro T, Guerreiro P, Gerhardt E, Kröhnert K, Klucken J, Pereira MD, Popova B, Kruse N, Mollenhauer B, Rizzoli SO, Braus GH, ... ... Outeiro TF, et al. Systematic comparison of the effects of alpha-synuclein mutations on its oligomerization and aggregation. Plos Genetics. 10: e1004741. PMID 25393002 DOI: 10.1371/journal.pgen.1004741  0.32
2014 Shahpasandzadeh H, Popova B, Kleinknecht A, Fraser PE, Outeiro TF, Braus GH. Interplay between sumoylation and phosphorylation for protection against α-synuclein inclusions. The Journal of Biological Chemistry. 289: 31224-40. PMID 25231978 DOI: 10.1074/jbc.M114.559237  0.32
2014 Fernandes JT, Tenreiro S, Gameiro A, Chu V, Outeiro TF, Conde JP. Modulation of alpha-synuclein toxicity in yeast using a novel microfluidic-based gradient generator. Lab On a Chip. 14: 3949-57. PMID 25167219 DOI: 10.1039/c4lc00756e  0.32
2014 Perfeito R, Lázaro DF, Outeiro TF, Rego AC. Linking alpha-synuclein phosphorylation to reactive oxygen species formation and mitochondrial dysfunction in SH-SY5Y cells. Molecular and Cellular Neurosciences. 62: 51-9. PMID 25109238 DOI: 10.1016/j.mcn.2014.08.002  0.32
2014 Zondler L, Miller-Fleming L, Repici M, Gonçalves S, Tenreiro S, Rosado-Ramos R, Betzer C, Straatman KR, Jensen PH, Giorgini F, Outeiro TF. DJ-1 interactions with α-synuclein attenuate aggregation and cellular toxicity in models of Parkinson's disease. Cell Death & Disease. 5: e1350. PMID 25058424 DOI: 10.1038/cddis.2014.307  0.32
2014 Yin G, Lopes da Fonseca T, Eisbach SE, Anduaga AM, Breda C, Orcellet ML, Szeg? ÉM, Guerreiro P, Lázaro DF, Braus GH, Fernandez CO, Griesinger C, Becker S, Goody RS, Itzen A, ... ... Outeiro TF, et al. α-Synuclein interacts with the switch region of Rab8a in a Ser129 phosphorylation-dependent manner. Neurobiology of Disease. 70: 149-61. PMID 24983211 DOI: 10.1016/j.nbd.2014.06.018  0.32
2014 Tenreiro S, Eckermann K, Outeiro TF. Protein phosphorylation in neurodegeneration: friend or foe? Frontiers in Molecular Neuroscience. 7: 42. PMID 24860424 DOI: 10.3389/fnmol.2014.00042  0.32
2014 Tenreiro S, Reimão-Pinto MM, Antas P, Rino J, Wawrzycka D, Macedo D, Rosado-Ramos R, Amen T, Waiss M, Magalhães F, Gomes A, Santos CN, Kaganovich D, Outeiro TF. Phosphorylation modulates clearance of alpha-synuclein inclusions in a yeast model of Parkinson's disease. Plos Genetics. 10: e1004302. PMID 24810576 DOI: 10.1371/journal.pgen.1004302  0.32
2014 Miller-Fleming L, Antas P, Pais TF, Smalley JL, Giorgini F, Outeiro TF. Yeast DJ-1 superfamily members are required for diauxic-shift reprogramming and cell survival in stationary phase. Proceedings of the National Academy of Sciences of the United States of America. 111: 7012-7. PMID 24706893 DOI: 10.1073/pnas.1319221111  0.32
2014 Rodrigues TM, Jerónimo-Santos A, Outeiro TF, Sebastião AM, Diógenes MJ. Challenges and promises in the development of neurotrophic factor-based therapies for Parkinson's disease. Drugs & Aging. 31: 239-61. PMID 24610720 DOI: 10.1007/s40266-014-0160-x  0.32
2014 Vittori A, Breda C, Repici M, Orth M, Roos RA, Outeiro TF, Giorgini F, Hollox EJ. Copy-number variation of the neuronal glucose transporter gene SLC2A3 and age of onset in Huntington's disease. Human Molecular Genetics. 23: 3129-37. PMID 24452335 DOI: 10.1093/hmg/ddu022  0.32
2014 McFarland KN, Huizenga MN, Darnell SB, Sangrey GR, Berezovska O, Cha JH, Outeiro TF, Sadri-Vakili G. MeCP2: a novel Huntingtin interactor. Human Molecular Genetics. 23: 1036-44. PMID 24105466 DOI: 10.1093/hmg/ddt499  0.32
2014 Sajjad MU, Green EW, Miller-Fleming L, Hands S, Herrera F, Campesan S, Khoshnan A, Outeiro TF, Giorgini F, Wyttenbach A. DJ-1 modulates aggregation and pathogenesis in models of Huntington's disease. Human Molecular Genetics. 23: 755-66. PMID 24070869 DOI: 10.1093/hmg/ddt466  0.32
2014 Fernandes JTS, Tenreiro S, Pedrosa CR, Gameiro A, Chu V, Outeiro TF, Conde JP. Integration of single cell traps, chemical gradient generator and photosensors in a microfluidic platform for the study of alphasynuclein toxicity in yeast Procedia Engineering. 87: 92-95. DOI: 10.1016/j.proeng.2014.11.273  0.32
2013 Vittori A, Orth M, Roos RA, Outeiro TF, Giorgini F, Hollox EJ. β-Defensin genomic copy number does not influence the age of onset in Huntington's Disease. Journal of Huntington's Disease. 2: 107-24. PMID 25057107 DOI: 10.3233/JHD-130002  0.32
2013 Wales P, Pinho R, Lázaro DF, Outeiro TF. Limelight on alpha-synuclein: pathological and mechanistic implications in neurodegeneration. Journal of Parkinson's Disease. 3: 415-59. PMID 24270242 DOI: 10.3233/JPD-130216  0.32
2013 Fagerqvist T, Näsström T, Ihse E, Lindström V, Sahlin C, Tucker SM, Kasaryan A, Karlsson M, Nikolajeff F, Schell H, Outeiro TF, Kahle PJ, Lannfelt L, Ingelsson M, Bergström J. Off-pathway α-synuclein oligomers seem to alter α-synuclein turnover in a cell model but lack seeding capability in vivo. Amyloid : the International Journal of Experimental and Clinical Investigation : the Official Journal of the International Society of Amyloidosis. 20: 233-44. PMID 24053224 DOI: 10.3109/13506129.2013.835726  0.32
2013 Pais TF, SzegÅ‘ ÉM, Marques O, Miller-Fleming L, Antas P, Guerreiro P, de Oliveira RM, Kasapoglu B, Outeiro TF. The NAD-dependent deacetylase sirtuin 2 is a suppressor of microglial activation and brain inflammation. The Embo Journal. 32: 2603-16. PMID 24013120 DOI: 10.1038/emboj.2013.200  0.32
2013 Basso E, Antas P, Marijanovic Z, Gonçalves S, Tenreiro S, Outeiro TF. PLK2 modulates α-synuclein aggregation in yeast and mammalian cells. Molecular Neurobiology. 48: 854-62. PMID 23677647 DOI: 10.1007/s12035-013-8473-z  0.32
2013 Amaral M, Outeiro TF, Scrutton NS, Giorgini F. The causative role and therapeutic potential of the kynurenine pathway in neurodegenerative disease. Journal of Molecular Medicine (Berlin, Germany). 91: 705-13. PMID 23636512 DOI: 10.1007/s00109-013-1046-9  0.32
2013 Eisbach SE, Outeiro TF. Alpha-synuclein and intracellular trafficking: impact on the spreading of Parkinson's disease pathology. Journal of Molecular Medicine (Berlin, Germany). 91: 693-703. PMID 23616088 DOI: 10.1007/s00109-013-1038-9  0.32
2013 Faria C, Jorge CD, Borges N, Tenreiro S, Outeiro TF, Santos H. Inhibition of formation of α-synuclein inclusions by mannosylglycerate in a yeast model of Parkinson's disease. Biochimica Et Biophysica Acta. 1830: 4065-72. PMID 23608058 DOI: 10.1016/j.bbagen.2013.04.015  0.32
2013 Tenreiro S, Munder MC, Alberti S, Outeiro TF. Harnessing the power of yeast to unravel the molecular basis of neurodegeneration. Journal of Neurochemistry. 127: 438-52. PMID 23600759 DOI: 10.1111/jnc.12271  0.32
2013 Amaral M, Levy C, Heyes DJ, Lafite P, Outeiro TF, Giorgini F, Leys D, Scrutton NS. Structural basis of kynurenine 3-monooxygenase inhibition. Nature. 496: 382-5. PMID 23575632 DOI: 10.1038/nature12039  0.32
2013 Taschenberger G, Toloe J, Tereshchenko J, Akerboom J, Wales P, Benz R, Becker S, Outeiro TF, Looger LL, Bähr M, Zweckstetter M, Kügler S. β-synuclein aggregates and induces neurodegeneration in dopaminergic neurons. Annals of Neurology. 74: 109-18. PMID 23536356 DOI: 10.1002/ana.23905  0.32
2013 Vicente Miranda H, Xiang W, de Oliveira RM, Simões T, Pimentel J, Klucken J, Penque D, Outeiro TF. Heat-mediated enrichment of α-synuclein from cells and tissue for assessing post-translational modifications. Journal of Neurochemistry. 126: 673-84. PMID 23534813 DOI: 10.1111/jnc.12251  0.32
2013 Schildknecht S, Gerding HR, Karreman C, Drescher M, Lashuel HA, Outeiro TF, Di Monte DA, Leist M. Oxidative and nitrative alpha-synuclein modifications and proteostatic stress: implications for disease mechanisms and interventions in synucleinopathies. Journal of Neurochemistry. 125: 491-511. PMID 23452040 DOI: 10.1111/jnc.12226  0.32
2013 Donmez G, Outeiro TF. SIRT1 and SIRT2: emerging targets in neurodegeneration. Embo Molecular Medicine. 5: 344-52. PMID 23417962 DOI: 10.1002/emmm.201302451  0.32
2013 Gonçalves S, Outeiro TF. Assessing the subcellular dynamics of alpha-synuclein using photoactivation microscopy. Molecular Neurobiology. 47: 1081-92. PMID 23389286 DOI: 10.1007/s12035-013-8406-x  0.32
2013 Amaral JD, Herrera F, Rodrigues PM, Dionísio PA, Outeiro TF, Rodrigues CM. Live-cell imaging of p53 interactions using a novel Venus-based bimolecular fluorescence complementation system. Biochemical Pharmacology. 85: 745-52. PMID 23261524 DOI: 10.1016/j.bcp.2012.12.009  0.32
2013 Guerreiro PS, Huang Y, Gysbers A, Cheng D, Gai WP, Outeiro TF, Halliday GM. LRRK2 interactions with α-synuclein in Parkinson's disease brains and in cell models. Journal of Molecular Medicine (Berlin, Germany). 91: 513-22. PMID 23183827 DOI: 10.1007/s00109-012-0984-y  0.32
2013 Repici M, Straatman KR, Balduccio N, Enguita FJ, Outeiro TF, Giorgini F. Parkinson's disease-associated mutations in DJ-1 modulate its dimerization in living cells. Journal of Molecular Medicine (Berlin, Germany). 91: 599-611. PMID 23183826 DOI: 10.1007/s00109-012-0976-y  0.32
2013 Marques S, Outeiro TF. Epigenetics in Parkinson's and Alzheimer's diseases. Sub-Cellular Biochemistry. 61: 507-25. PMID 23150265 DOI: 10.1007/978-94-007-4525-4_22  0.32
2013 Lopes da Fonseca T, Correia A, Hasselaar W, van der Linde HC, Willemsen R, Outeiro TF. The zebrafish homologue of Parkinson's disease ATP13A2 is essential for embryonic survival. Brain Research Bulletin. 90: 118-26. PMID 23123961 DOI: 10.1016/j.brainresbull.2012.09.017  0.32
2013 Szeg? ÉM, Outeiro TF, Kermer P, Schulz JB. Impairment of the septal cholinergic neurons in MPTP-treated A30P α-synuclein mice. Neurobiology of Aging. 34: 589-601. PMID 22579457 DOI: 10.1016/j.neurobiolaging.2012.04.012  0.32
2012 Diógenes MJ, Dias RB, Rombo DM, Vicente Miranda H, Maiolino F, Guerreiro P, Näsström T, Franquelim HG, Oliveira LM, Castanho MA, Lannfelt L, Bergström J, Ingelsson M, Quintas A, Sebastião AM, ... ... Outeiro TF, et al. Extracellular alpha-synuclein oligomers modulate synaptic transmission and impair LTP via NMDA-receptor activation. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 32: 11750-62. PMID 22915117 DOI: 10.1523/JNEUROSCI.0234-12.2012  0.32
2012 Sampaio-Marques B, Felgueiras C, Silva A, Rodrigues M, Tenreiro S, Franssens V, Reichert AS, Outeiro TF, Winderickx J, Ludovico P. SNCA (α-synuclein)-induced toxicity in yeast cells is dependent on sirtuin 2 (Sir2)-mediated mitophagy. Autophagy. 8: 1494-509. PMID 22914317 DOI: 10.4161/auto.21275  0.32
2012 Marques O, Outeiro TF. Alpha-synuclein: from secretion to dysfunction and death. Cell Death & Disease. 3: e350. PMID 22825468 DOI: 10.1038/cddis.2012.94  0.32
2012 Marques SC, Lemos R, Ferreiro E, Martins M, de Mendonça A, Santana I, Outeiro TF, Pereira CM. Epigenetic regulation of BACE1 in Alzheimer's disease patients and in transgenic mice. Neuroscience. 220: 256-66. PMID 22728099 DOI: 10.1016/j.neuroscience.2012.06.029  0.32
2012 Petroi D, Popova B, Taheri-Talesh N, Irniger S, Shahpasandzadeh H, Zweckstetter M, Outeiro TF, Braus GH. Aggregate clearance of α-synuclein in Saccharomyces cerevisiae depends more on autophagosome and vacuole function than on the proteasome. The Journal of Biological Chemistry. 287: 27567-79. PMID 22722939 DOI: 10.1074/jbc.M112.361865  0.32
2012 Rosa P, Tenreiro S, Chu V, Outeiro TF, Conde JP. High-throughput study of alpha-synuclein expression in yeast using microfluidics for control of local cellular microenvironment. Biomicrofluidics. 6: 14109-141099. PMID 22662094 DOI: 10.1063/1.3683161  0.32
2012 Maxwell MM, Zaldivar-Jolissaint JF, Mai A, Outeiro TF, Kazanstev AG. Highlights of the Keystone Symposium: sirtuins in metabolism, aging and disease. Embo Molecular Medicine. 4: 557-60. PMID 22610822 DOI: 10.1002/emmm.201201452  0.32
2012 de Oliveira RM, Sarkander J, Kazantsev AG, Outeiro TF. SIRT2 as a Therapeutic Target for Age-Related Disorders. Frontiers in Pharmacology. 3: 82. PMID 22563317 DOI: 10.3389/fphar.2012.00082  0.32
2012 Kazantsev AG, Outeiro TF. Editorial on special topic: sirtuins in metabolism, aging, and disease. Frontiers in Pharmacology. 3: 71. PMID 22536186 DOI: 10.3389/fphar.2012.00071  0.32
2012 Sancenon V, Lee SA, Patrick C, Griffith J, Paulino A, Outeiro TF, Reggiori F, Masliah E, Muchowski PJ. Suppression of α-synuclein toxicity and vesicle trafficking defects by phosphorylation at S129 in yeast depends on genetic context. Human Molecular Genetics. 21: 2432-49. PMID 22357655 DOI: 10.1093/hmg/dds058  0.32
2012 Herrera F, Gonçalves S, Outeiro TF. Imaging protein oligomerization in neurodegeneration using bimolecular fluorescence complementation. Methods in Enzymology. 506: 157-74. PMID 22341224 DOI: 10.1016/B978-0-12-391856-7.00033-0  0.32
2012 Kemppainen S, Rantamäki T, Jerónimo-Santos A, Lavasseur G, Autio H, Karpova N, Kärkkäinen E, Stavén S, Vicente Miranda H, Outeiro TF, Diógenes MJ, Laroche S, Davis S, Sebastião AM, Castrén E, et al. Impaired TrkB receptor signaling contributes to memory impairment in APP/PS1 mice. Neurobiology of Aging. 33: 1122.e23-39. PMID 22209410 DOI: 10.1016/j.neurobiolaging.2011.11.006  0.32
2012 Herrera F, Outeiro TF. α-Synuclein modifies huntingtin aggregation in living cells. Febs Letters. 586: 7-12. PMID 22119730 DOI: 10.1016/j.febslet.2011.11.019  0.32
2012 Gonçalves S, Miranda HV, Outeiro TF. Novel Molecular Therapeutics in Parkinson's Disease Molecular and Cellular Therapeutics. 245-265. DOI: 10.1002/9781119967309.ch11  0.32
2011 Gerhardt E, Gräber S, Szego EM, Moisoi N, Martins LM, Outeiro TF, Kermer P. Idebenone and resveratrol extend lifespan and improve motor function of HtrA2 knockout mice. Plos One. 6: e28855. PMID 22205977 DOI: 10.1371/journal.pone.0028855  0.32
2011 Ribeiro Morais G, Vicente Miranda H, Santos IC, Santos I, Outeiro TF, Paulo A. Synthesis and in vitro evaluation of fluorinated styryl benzazoles as amyloid-probes. Bioorganic & Medicinal Chemistry. 19: 7698-710. PMID 22078413 DOI: 10.1016/j.bmc.2011.09.065  0.32
2011 Näsström T, Gonçalves S, Sahlin C, Nordström E, Screpanti Sundquist V, Lannfelt L, Bergström J, Outeiro TF, Ingelsson M. Antibodies against alpha-synuclein reduce oligomerization in living cells. Plos One. 6: e27230. PMID 22073131 DOI: 10.1371/journal.pone.0027230  0.32
2011 Badiola N, de Oliveira RM, Herrera F, Guardia-Laguarta C, Gonçalves SA, Pera M, Suárez-Calvet M, Clarimon J, Outeiro TF, Lleó A. Tau enhances α-synuclein aggregation and toxicity in cellular models of synucleinopathy. Plos One. 6: e26609. PMID 22039514 DOI: 10.1371/journal.pone.0026609  0.32
2011 Martins M, Rosa A, Guedes LC, Fonseca BV, Gotovac K, Violante S, Mestre T, Coelho M, Rosa MM, Martin ER, Vance JM, Outeiro TF, Wang L, Borovecki F, Ferreira JJ, et al. Convergence of miRNA expression profiling, α-synuclein interacton and GWAS in Parkinson's disease. Plos One. 6: e25443. PMID 22003392 DOI: 10.1371/journal.pone.0025443  0.32
2011 Swinnen E, Büttner S, Outeiro TF, Galas MC, Madeo F, Winderickx J, Franssens V. Aggresome formation and segregation of inclusions influence toxicity of α-synuclein and synphilin-1 in yeast. Biochemical Society Transactions. 39: 1476-81. PMID 21936837 DOI: 10.1042/BST0391476  0.32
2011 Outeiro TF. Amyloidogenesis: FlAsH illuminates Aβ aggregation. Nature Chemical Biology. 7: 581-2. PMID 21849997 DOI: 10.1038/nchembio.636  0.32
2011 Szego ÉM, Gerhardt E, Outeiro TF, Kermer P. Dopamine-depletion and increased α-synuclein load induce degeneration of cortical cholinergic fibers in mice. Journal of the Neurological Sciences. 310: 90-5. PMID 21774947 DOI: 10.1016/j.jns.2011.06.048  0.32
2011 de Oliveira RM, Marijanovic Z, Carvalho F, Miltényi GM, Matos JE, Tenreiro S, Oliveira S, Enguita FJ, Stone R, Outeiro TF. Impaired proteostasis contributes to renal tubular dysgenesis. Plos One. 6: e20854. PMID 21695262 DOI: 10.1371/journal.pone.0020854  0.32
2011 Jorge CD, Ventura R, Maycock C, Outeiro TF, Santos H, Costa J. Assessment of the efficacy of solutes from extremophiles on protein aggregation in cell models of Huntington's and Parkinson's diseases. Neurochemical Research. 36: 1005-11. PMID 21416120 DOI: 10.1007/s11064-011-0440-3  0.32
2011 Herrera F, Tenreiro S, Miller-Fleming L, Outeiro TF. Visualization of cell-to-cell transmission of mutant huntingtin oligomers. Plos Currents. 3: RRN1210. PMID 21331289 DOI: 10.1371/currents.RRN1210  0.32
2011 Hansen C, Angot E, Bergström AL, Steiner JA, Pieri L, Paul G, Outeiro TF, Melki R, Kallunki P, Fog K, Li JY, Brundin P. α-Synuclein propagates from mouse brain to grafted dopaminergic neurons and seeds aggregation in cultured human cells. The Journal of Clinical Investigation. 121: 715-25. PMID 21245577 DOI: 10.1172/JCI43366  0.32
2011 Tauber E, Miller-Fleming L, Mason RP, Kwan W, Clapp J, Butler NJ, Outeiro TF, Muchowski PJ, Giorgini F. Functional gene expression profiling in yeast implicates translational dysfunction in mutant huntingtin toxicity. The Journal of Biological Chemistry. 286: 410-9. PMID 21044956 DOI: 10.1074/jbc.M110.101527  0.32
2011 Marques SC, Oliveira CR, Pereira CM, Outeiro TF. Epigenetics in neurodegeneration: a new layer of complexity. Progress in Neuro-Psychopharmacology & Biological Psychiatry. 35: 348-55. PMID 20736041 DOI: 10.1016/j.pnpbp.2010.08.008  0.32
2011 Outeiro TF, Lopes LV. Synaptic dysfunction in Parkinson's disease: From protein misfolding to functional alterations Folding For the Synapse. 257-267. DOI: 10.1007/978-1-4419-7061-9-13  0.32
2011 Marques SCF, Pereira CMF, Outeiro TF. Epigenetics and neurodegeneration: Unveiling the complexity Bio Tech International. 23: 16-19.  0.32
2011 Marques SCF, Pereira CMF, Outeiro TF. Epigenetics and neurodegeneration: A connection overlooked Epigenetics: Mechanisms, Functions and Human Effects. 241-252.  0.32
2010 da Costa G, Guerreiro A, Correia CF, Gomes RJ, Freire A, Monteiro E, Barroso E, Coelho AV, Outeiro TF, Freire AP, Cordeiro C. A non-invasive method based on saliva to characterize transthyretin in familial amyloidotic polyneuropathy patients using FT-ICR high-resolution MS. Proteomics. Clinical Applications. 4: 674-8. PMID 21179887 DOI: 10.1002/prca.200900118  0.32
2010 Büttner S, Delay C, Franssens V, Bammens T, Ruli D, Zaunschirm S, de Oliveira RM, Outeiro TF, Madeo F, Buée L, Galas MC, Winderickx J. Synphilin-1 enhances α-synuclein aggregation in yeast and contributes to cellular stress and cell death in a Sir2-dependent manner. Plos One. 5: e13700. PMID 21060871 DOI: 10.1371/journal.pone.0013700  0.32
2010 Diógenes MJ, Outeiro TF. Neurotrophic factors as a protective strategy in Parkinson's disease. Cns & Neurological Disorders Drug Targets. 9: 754-63. PMID 20942787  0.32
2010 Kazantsev AG, Outeiro TF. Drug discovery for CNS disorders: from bench to bedside. Cns & Neurological Disorders Drug Targets. 9: 668. PMID 20942783 DOI: 10.2174/187152710793237395  0.32
2010 de Oliveira RM, Pais TF, Outeiro TF. Sirtuins: common targets in aging and in neurodegeneration. Current Drug Targets. 11: 1270-80. PMID 20840069  0.32
2010 Tenreiro S, Outeiro TF. Simple is good: yeast models of neurodegeneration. Fems Yeast Research. 10: 970-9. PMID 20579105 DOI: 10.1111/j.1567-1364.2010.00649.x  0.32
2010 Gonçalves SA, Matos JE, Outeiro TF. Zooming into protein oligomerization in neurodegeneration using BiFC. Trends in Biochemical Sciences. 35: 643-51. PMID 20561791 DOI: 10.1016/j.tibs.2010.05.007  0.32
2010 Marques SC, Oliveira CR, Outeiro TF, Pereira CM. Alzheimer's disease: the quest to understand complexity. Journal of Alzheimer's Disease : Jad. 21: 373-83. PMID 20555132 DOI: 10.3233/JAD-2010-100303  0.32
2010 Nakhjavani M, Morteza A, Khajeali L, Esteghamati A, Khalilzadeh O, Asgarani F, Outeiro TF. Increased serum HSP70 levels are associated with the duration of diabetes. Cell Stress & Chaperones. 15: 959-64. PMID 20496051 DOI: 10.1007/s12192-010-0204-z  0.32
2010 Vicente Miranda H, Outeiro TF. The sour side of neurodegenerative disorders: the effects of protein glycation. The Journal of Pathology. 221: 13-25. PMID 20186922 DOI: 10.1002/path.2682  0.32
2010 Su LJ, Auluck PK, Outeiro TF, Yeger-Lotem E, Kritzer JA, Tardiff DF, Strathearn KE, Liu F, Cao S, Hamamichi S, Hill KJ, Caldwell KA, Bell GW, Fraenkel E, Cooper AA, et al. Compounds from an unbiased chemical screen reverse both ER-to-Golgi trafficking defects and mitochondrial dysfunction in Parkinson's disease models. Disease Models & Mechanisms. 3: 194-208. PMID 20038714 DOI: 10.1242/dmm.004267  0.32
2009 da Costa G, Gomes R, Correia CF, Freire A, Monteiro E, Martins A, Barroso E, Coelho AV, Outeiro TF, Ponces Freire A, Cordeiro C. Identification and quantitative analysis of human transthyretin variants in human serum by Fourier transform ion-cyclotron resonance mass spectrometry. Amyloid : the International Journal of Experimental and Clinical Investigation : the Official Journal of the International Society of Amyloidosis. 16: 201-7. PMID 19922331 DOI: 10.3109/13506120903421561  0.32
2009 Outeiro TF, Ferreira J. Current and future therapeutic strategies for Parkinson's disease. Current Pharmaceutical Design. 15: 3968-76. PMID 19751203 DOI: 10.2174/138161209789649321  0.32
2008 Mollenhauer B, Cullen V, Kahn I, Krastins B, Outeiro TF, Pepivani I, Ng J, Schulz-Schaeffer W, Kretzschmar HA, McLean PJ, Trenkwalder C, Sarracino DA, Vonsattel JP, Locascio JJ, El-Agnaf OM, et al. Direct quantification of CSF alpha-synuclein by ELISA and first cross-sectional study in patients with neurodegeneration. Experimental Neurology. 213: 315-25. PMID 18625222 DOI: 10.1016/j.expneurol.2008.06.004  0.32
2008 Tetzlaff JE, Putcha P, Outeiro TF, Ivanov A, Berezovska O, Hyman BT, McLean PJ. CHIP targets toxic alpha-Synuclein oligomers for degradation. The Journal of Biological Chemistry. 283: 17962-8. PMID 18436529 DOI: 10.1074/jbc.M802283200  0.32
2008 Outeiro TF, Putcha P, Tetzlaff JE, Spoelgen R, Koker M, Carvalho F, Hyman BT, McLean PJ. Formation of toxic oligomeric alpha-synuclein species in living cells. Plos One. 3: e1867. PMID 18382657 DOI: 10.1371/journal.pone.0001867  0.32
2008 Fleming J, Outeiro TF, Slack M, Lindquist SL, Bulawa CE. Detection of compounds that rescue Rab1-synuclein toxicity. Methods in Enzymology. 439: 339-51. PMID 18374176 DOI: 10.1016/S0076-6879(07)00425-9  0.32
2008 Outeiro TF, Marques O, Kazantsev A. Therapeutic role of sirtuins in neurodegenerative disease. Biochimica Et Biophysica Acta. 1782: 363-9. PMID 18373985 DOI: 10.1016/j.bbadis.2008.02.010  0.32
2008 Miller-Fleming L, Giorgini F, Outeiro TF. Yeast as a model for studying human neurodegenerative disorders. Biotechnology Journal. 3: 325-38. PMID 18228539 DOI: 10.1002/biot.200700217  0.32
2008 Outeiro TF. From mad cows to neurotic yeast: Novel molecular approaches to understand neurodegeneration Microscopy and Microanalysis. 14: 105-106. DOI: 10.1017/S143192760808954X  0.32
2008 Outeiro TF, Kazantsev A. Drug targeting of α-synuclein oligomerization in synucleinopathies Perspectives in Medicinal Chemistry. 2008: 41-49.  0.32
2007 Grammatopoulos TN, Outeiro TF, Hyman BT, Standaert DG. Angiotensin II protects against alpha-synuclein toxicity and reduces protein aggregation in vitro. Biochemical and Biophysical Research Communications. 363: 846-51. PMID 17900533 DOI: 10.1016/j.bbrc.2007.09.043  0.32
2007 Outeiro TF, Kontopoulos E, Altmann SM, Kufareva I, Strathearn KE, Amore AM, Volk CB, Maxwell MM, Rochet JC, McLean PJ, Young AB, Abagyan R, Feany MB, Hyman BT, Kazantsev AG. Sirtuin 2 inhibitors rescue alpha-synuclein-mediated toxicity in models of Parkinson's disease. Science (New York, N.Y.). 317: 516-9. PMID 17588900 DOI: 10.1126/science.1143780  0.32
2007 Outeiro TF, Grammatopoulos TN, Altmann S, Amore A, Standaert DG, Hyman BT, Kazantsev AG. Pharmacological inhibition of PARP-1 reduces alpha-synuclein- and MPP+-induced cytotoxicity in Parkinson's disease in vitro models. Biochemical and Biophysical Research Communications. 357: 596-602. PMID 17449015 DOI: 10.1016/j.bbrc.2007.03.163  0.32
2007 St Martin JL, Klucken J, Outeiro TF, Nguyen P, Keller-McGandy C, Cantuti-Castelvetri I, Grammatopoulos TN, Standaert DG, Hyman BT, McLean PJ. Dopaminergic neuron loss and up-regulation of chaperone protein mRNA induced by targeted over-expression of alpha-synuclein in mouse substantia nigra. Journal of Neurochemistry. 100: 1449-57. PMID 17241127 DOI: 10.1111/j.1471-4159.2006.04310.x  0.32
2007 Outeiro TF, McLean PJ, Hyman BT. Protein aggregation disorders Neurobiology of Disease. 111-123. DOI: 10.1016/B978-012088592-3/50012-8  0.32
2006 Outeiro TF, Klucken J, Strathearn KE, Liu F, Nguyen P, Rochet JC, Hyman BT, McLean PJ. Small heat shock proteins protect against alpha-synuclein-induced toxicity and aggregation. Biochemical and Biophysical Research Communications. 351: 631-8. PMID 17081499 DOI: 10.1016/j.bbrc.2006.10.085  0.32
2006 Klucken J, Outeiro TF, Nguyen P, McLean PJ, Hyman BT. Detection of novel intracellular alpha-synuclein oligomeric species by fluorescence lifetime imaging. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 20: 2050-7. PMID 17012257 DOI: 10.1096/fj.05-5422com  0.32
2006 Outeiro TF. A bridge from Portugal to the States. Nature. 443: 118. PMID 17001768  0.32
2006 Outeiro TF, Giorgini F. Yeast as a drug discovery platform in Huntington's and Parkinson's diseases. Biotechnology Journal. 1: 258-69. PMID 16897706 DOI: 10.1002/biot.200500043  0.32
2006 Bodner RA, Outeiro TF, Altmann S, Maxwell MM, Cho SH, Hyman BT, McLean PJ, Young AB, Housman DE, Kazantsev AG. Pharmacological promotion of inclusion formation: a therapeutic approach for Huntington's and Parkinson's diseases. Proceedings of the National Academy of Sciences of the United States of America. 103: 4246-51. PMID 16537516 DOI: 10.1073/pnas.0511256103  0.32
2004 Derkatch IL, Uptain SM, Outeiro TF, Krishnan R, Lindquist SL, Liebman SW. Effects of Q/N-rich, polyQ, and non-polyQ amyloids on the de novo formation of the [PSI+] prion in yeast and aggregation of Sup35 in vitro. Proceedings of the National Academy of Sciences of the United States of America. 101: 12934-9. PMID 15326312 DOI: 10.1073/pnas.0404968101  0.32
2004 Outeiro TF, Muchowski PJ. Molecular genetics approaches in yeast to study amyloid diseases. Journal of Molecular Neuroscience : Mn. 23: 49-60. PMID 15126692 DOI: 10.1385/JMN:23:1-2:049  0.32
2004 Rochet JC, Outeiro TF, Conway KA, Ding TT, Volles MJ, Lashuel HA, Bieganski RM, Lindquist SL, Lansbury PT. Interactions among alpha-synuclein, dopamine, and biomembranes: some clues for understanding neurodegeneration in Parkinson's disease. Journal of Molecular Neuroscience : Mn. 23: 23-34. PMID 15126689 DOI: 10.1385/JMN:23:1-2:023  0.32
2004 Da Cruz E Silva EF, Outeiro TF, Da Cruz E Silva OAB. Symposium on novel therapeutic opportunities for neurodegenerative disease Journal of Molecular Neuroscience. 23: 1-2. DOI: 10.1385/JMN:23:1-2:001  0.32
2003 Outeiro TF, Lindquist S. Yeast cells provide insight into alpha-synuclein biology and pathobiology. Science (New York, N.Y.). 302: 1772-5. PMID 14657500 DOI: 10.1126/science.1090439  0.32
2003 Willingham S, Outeiro TF, DeVit MJ, Lindquist SL, Muchowski PJ. Yeast genes that enhance the toxicity of a mutant huntingtin fragment or alpha-synuclein. Science (New York, N.Y.). 302: 1769-72. PMID 14657499 DOI: 10.1126/science.1090389  0.32
2003 Resende CG, Outeiro TF, Sands L, Lindquist S, Tuite MF. Prion protein gene polymorphisms in Saccharomyces cerevisiae. Molecular Microbiology. 49: 1005-17. PMID 12890024 DOI: 10.1046/j.1365-2958.2003.03608.x  0.32
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