Tiago Fleming Outeiro, Ph.D. - Related publications

Neuroscience Unit, Institute of Molecular Medicine University of Lisbon, Lisboa, Lisboa, Portugal 
models of neurodegenerative disease, sreening
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50 most relevant papers in past 60 days:
Year Citation  Score
2021 Madsen DA, Schmidt SI, Blaabjerg M, Meyer M. Interaction between Parkin and -Synuclein in -Mediated Parkinson's Disease. Cells. 10. PMID 33572534 DOI: 10.3390/cells10020283   
2021 Bindas AJ, Kulkarni S, Koppes RA, Koppes AN. Parkinson's disease and the gut: Models of an emerging relationship. Acta Biomaterialia. PMID 33857691 DOI: 10.1016/j.actbio.2021.03.071   
2021 Giri B, Seamon M, Banerjee A, Chauhan S, Purohit S, Morgan J, Baban B, Wakade C. Emerging urinary alpha-synuclein and miRNA biomarkers in Parkinson's disease. Metabolic Brain Disease. PMID 33881722 DOI: 10.1007/s11011-021-00735-2   
2021 Miller KM, Mercado NM, Sortwell CE. Synucleinopathy-associated pathogenesis in Parkinson's disease and the potential for brain-derived neurotrophic factor. Npj Parkinson's Disease. 7: 35. PMID 33846345 DOI: 10.1038/s41531-021-00179-6   
2021 MacDougall G, Brown LY, Kantor B, Chiba-Falek O. The Path to Progress Preclinical Studies of Age-Related Neurodegenerative Diseases: A Perspective on Rodent and hiPSC-Derived Models. Molecular Therapy : the Journal of the American Society of Gene Therapy. 29: 949-972. PMID 33429080 DOI: 10.1016/j.ymthe.2021.01.001   
2021 Martinez-Valbuena I, Valenti-Azcarate R, Amat-Villegas I, Marcilla I, Marti-Andres G, Caballero MC, Riverol M, Tuñon MT, Fraser PE, Luquin MR. Mixed pathologies in pancreatic β cells from subjects with neurodegenerative diseases and their interaction with prion protein. Acta Neuropathologica Communications. 9: 64. PMID 33832546 DOI: 10.1186/s40478-021-01171-0   
2021 Bloem BR, Okun MS, Klein C. Parkinson's disease. Lancet (London, England). PMID 33848468 DOI: 10.1016/S0140-6736(21)00218-X   
2021 Dean DN, Lee JC. Linking Parkinson's Disease and Melanoma: Interplay Between α-Synuclein and Pmel17 Amyloid Formation. Movement Disorders : Official Journal of the Movement Disorder Society. PMID 34021920 DOI: 10.1002/mds.28655   
2021 Mirelman A, Ben Or Frank M, Melamed M, Granovsky L, Nieuwboer A, Rochester L, Del Din S, Avanzino L, Pelosin E, Bloem BR, Della Croce U, Cereatti A, Bonato P, Camicioli R, Ellis T, et al. Detecting Sensitive Mobility Features for Parkinson's Disease Stages Via Machine Learning. Movement Disorders : Official Journal of the Movement Disorder Society. PMID 33955603 DOI: 10.1002/mds.28631   
2021 Lobine D, Sadeer N, Jugreet S, Suroowan S, Keenoo BS, Imran M, Venugopala KN, Ibrahim FM, Zengin G, Mahomoodally MF. Potential of medicinal plants as neuroprotective and therapeutic properties against amyloid-β-related toxicity, and glutamate-induced excitotoxicity in human neural cells. Current Neuropharmacology. PMID 33845746 DOI: 10.2174/1570159X19666210412095251   
2021 Chen Y, Wu W, Zhao S, Lv X, Hu J, Han C, Wang G, Wang S, Bo P, Zhang J, Gui W, Tang Q, Liu Q, Zhu S, Yu F. Increased Accumulation of α-Synuclein in Inflamed Appendices of Parkinson's Disease Patients. Movement Disorders : Official Journal of the Movement Disorder Society. PMID 33876851 DOI: 10.1002/mds.28553   
2021 Stoyka LE, Mahoney CL, Thrasher DR, Russell DL, Cook AK, Harris AT, Narayanan A, Janado TP, Standaert DG, Roberson ED, Volpicelli-Daley LA. Templated α-synuclein inclusion formation is independent of endogenous tau. Eneuro. PMID 33972291 DOI: 10.1523/ENEURO.0458-20.2021   
2021 Cagin U. Targeting Age-Related Neurodegenerative Diseases by AAV-Mediated Gene Therapy. Advances in Experimental Medicine and Biology. 1286: 213-223. PMID 33725356 DOI: 10.1007/978-3-030-55035-6_15   
2021 Pope ED, Cordes L, Shi J, Mari Z, Decourt B, Sabbagh MN. Dementia with Lewy bodies: emerging drug targets and therapeutics. Expert Opinion On Investigational Drugs. 1-7. PMID 33899637 DOI: 10.1080/13543784.2021.1916913   
2021 Ernest James Phillips T, Maguire E. Phosphoinositides: Roles in the Development of Microglial-Mediated Neuroinflammation and Neurodegeneration. Frontiers in Cellular Neuroscience. 15: 652593. PMID 33841102 DOI: 10.3389/fncel.2021.652593   
2021 Huang Y, Liao J, Liu X, Zhong Y, Cai X, Long L. Review: The Role of Intestinal Dysbiosis in Parkinson's Disease. Frontiers in Cellular and Infection Microbiology. 11: 615075. PMID 33968794 DOI: 10.3389/fcimb.2021.615075   
2021 Jin Y, Vadukul DM, Gialama D, Ge Y, Thrush R, White JT, Aprile FA. The Diagnostic Potential of Amyloidogenic Proteins. International Journal of Molecular Sciences. 22. PMID 33923609 DOI: 10.3390/ijms22084128   
2021 Pischedda F, Cirnaru MD, Ponzoni L, Sandre M, Biosa A, Carrion MP, Marin O, Morari M, Pan L, Greggio E, Bandopadhyay R, Sala M, Piccoli G. LRRK2 G2019S kinase activity triggers neurotoxic NSF aggregation. Brain : a Journal of Neurology. PMID 33876242 DOI: 10.1093/brain/awab073   
2021 Caruana M, Camilleri A, Farrugia MY, Ghio S, Jakubíčková M, Cauchi RJ, Vassallo N. Extract from the Marine Seaweed Protects Mitochondrial Biomembranes from Damage by Amyloidogenic Peptides. Molecules (Basel, Switzerland). 26. PMID 33799979 DOI: 10.3390/molecules26051444   
2021 Müller T, Mueller BK, Riederer P. Perspective: Treatment for Disease Modification in Chronic Neurodegeneration. Cells. 10. PMID 33921342 DOI: 10.3390/cells10040873   
2021 Li X, Feng X, Jiang Z, Jiang Z. Association of small intestinal bacterial overgrowth with Parkinson's disease: a systematic review and meta-analysis. Gut Pathogens. 13: 25. PMID 33863370 DOI: 10.1186/s13099-021-00420-w   
2021 Bridi JC, Bereczki E, Smith SK, Poças GM, Kottler B, Domingos PM, Elliott CJ, Aarsland D, Hirth F. Presynaptic accumulation of α-synuclein causes synaptopathy and progressive neurodegeneration in . Brain Communications. 3: fcab049. PMID 33997781 DOI: 10.1093/braincomms/fcab049   
2021 Majbour NK, Abdi IY, Dakna M, Wicke T, Lang E, Ali Moussa HY, Thomas MA, Trenkwalder C, Safieh-Garabedian B, Tokuda T, Mollenhauer B, El-Agnaf O. Cerebrospinal α-Synuclein Oligomers Reflect Disease Motor Severity in DeNoPa Longitudinal Cohort. Movement Disorders : Official Journal of the Movement Disorder Society. PMID 33978256 DOI: 10.1002/mds.28611   
2021 Wen X, Yang Y, Klionsky DJ. Moments in autophagy and disease: Past and present. Molecular Aspects of Medicine. 100966. PMID 33931245 DOI: 10.1016/j.mam.2021.100966   
2021 O'Regan GC, Farag SH, Casey CS, Wood-Kaczmar A, Pocock JM, Tabrizi SJ, Andre R. Human Huntington's disease pluripotent stem cell-derived microglia develop normally but are abnormally hyper-reactive and release elevated levels of reactive oxygen species. Journal of Neuroinflammation. 18: 94. PMID 33874957 DOI: 10.1186/s12974-021-02147-6   
2021 Pérez MJ, Baden P, Deleidi M. Progresses in both basic research and clinical trials of NAD+ in Parkinson's disease. Mechanisms of Ageing and Development. 111499. PMID 33989633 DOI: 10.1016/j.mad.2021.111499   
2021 Huang TI, Hsieh CL. Effects of Acupuncture on Oxidative Stress Amelioration via Nrf2/ARE-Related Pathways in Alzheimer and Parkinson Diseases. Evidence-Based Complementary and Alternative Medicine : Ecam. 2021: 6624976. PMID 33995547 DOI: 10.1155/2021/6624976   
2021 Ghosh S, Won SJ, Wang J, Fong R, Butler NJM, Moss A, Wong C, Pan J, Sanchez J, Huynh A, Wu L, Manfredsson FP, Swanson RA. α-synuclein aggregates induce c-Abl activation and dopaminergic neuronal loss by a feed-forward redox stress mechanism. Progress in Neurobiology. 102070. PMID 33951536 DOI: 10.1016/j.pneurobio.2021.102070   
2021 Zhu C, Bilousova T, Focht S, Jun M, Elias CJ, Melnik M, Chandra S, Campagna J, Cohn W, Hatami A, Spilman P, Gylys KH, John V. Pharmacological inhibition of nSMase2 reduces brain exosome release and α-synuclein pathology in a Parkinson's disease model. Molecular Brain. 14: 70. PMID 33875010 DOI: 10.1186/s13041-021-00776-9   
2021 Wang Q, Luo Y, Chaudhuri KR, Reynolds R, Tan EK, Pettersson S. The role of gut dysbiosis in Parkinson's disease: mechanistic insights andtherapeutic options. Brain : a Journal of Neurology. PMID 33856024 DOI: 10.1093/brain/awab156   
2021 Creekmore BC, Chang YW, Lee EB. The Cryo-EM Effect: Structural Biology of Neurodegenerative Disease Aggregates. Journal of Neuropathology and Experimental Neurology. PMID 33970243 DOI: 10.1093/jnen/nlab039   
2021 Ou GY, Lin WW, Zhao WJ. Neuregulins in Neurodegenerative Diseases. Frontiers in Aging Neuroscience. 13: 662474. PMID 33897409 DOI: 10.3389/fnagi.2021.662474   
2021 Haupt M, Bähr M, Doeppner TR. Lithium beyond psychiatric indications: the reincarnation of a new old drug. Neural Regeneration Research. 16: 2383-2387. PMID 33907010 DOI: 10.4103/1673-5374.313015   
2021 Priss A, Afitska K, Galkin M, Yushchenko DA, Shvadchak VV. Rationally Designed Protein-Based Inhibitor of α-Synuclein Fibrillization in Cells. Journal of Medicinal Chemistry. PMID 33970620 DOI: 10.1021/acs.jmedchem.1c00086   
2021 Yu Y, Liang S, Wang Y, Zhao Y, Zhao J, Li H, Wu J, Cheng Y, Wu F, Wu J. Quantitative Analysis of Postural Instability in Patients with Parkinson's Disease. Parkinson's Disease. 2021: 5681870. PMID 33936583 DOI: 10.1155/2021/5681870   
2021 Valderhaug VD, Heiney K, Huse Ramstad O, Braathen G, Kuan WL, Nichele S, Sandvig A, Sandvig I. Early functional changes associated with alpha-synuclein proteinopathy in engineered human neural networks. American Journal of Physiology. Cell Physiology. PMID 33950697 DOI: 10.1152/ajpcell.00413.2020   
2021 Wood A, Gurfinkel Y, Polain N, Lamont W, Lyn Rea S. Molecular Mechanisms Underlying TDP-43 Pathology in Cellular and Animal Models of ALS and FTLD. International Journal of Molecular Sciences. 22. PMID 33946763 DOI: 10.3390/ijms22094705   
2021 Raj A, Tora V, Gao X, Cho H, Choi JY, Ryu Y, Lyoo C, Franchi B. Combined Model of Aggregation And Network Diffusion Recapitulates Alzheimer's Regional Tau-PET. Brain Connectivity. PMID 33947253 DOI: 10.1089/brain.2020.0841   
2021 Mak S, Li W, Fu H, Luo J, Cui W, Hu S, Pang Y, Carlier PR, Tsim KW, Pi R, Han Y. Promising tacrine/huperzine A- based dimeric AChE inhibitors for neurodegenerative disorders: from relieving symptoms to modifying diseases through multi-target. Journal of Neurochemistry. PMID 33930191 DOI: 10.1111/jnc.15379   
2021 Pérez-Sisqués L, Martín-Flores N, Masana M, Solana J, Llobet A, Romaní-Aumedes J, Canal M, Campoy G, García-García E, Sánchez-Fernández N, Fernández-García S, Gilbert JP, Rodríguez MJ, Man HY, Feinstein E, et al. RTP801 regulates motor cortex synaptic transmission and learning. Experimental Neurology. 113755. PMID 33984337 DOI: 10.1016/j.expneurol.2021.113755   
2021 Shukla R, Singh TR. High-throughput screening of natural compounds and inhibition of a major therapeutic target HsGSK-3β for Alzheimer's disease using computational approaches. Journal, Genetic Engineering & Biotechnology. 19: 61. PMID 33945025 DOI: 10.1186/s43141-021-00163-w   
2021 Khoury R, Liu Y, Sheheryar Q, Grossberg GT. Pharmacotherapy for Frontotemporal Dementia. Cns Drugs. 35: 425-438. PMID 33840052 DOI: 10.1007/s40263-021-00813-0   
2021 Diaz-Lucena D, Kruse N, Thüne K, Schmitz M, Villar-Piqué A, da Cunha JEG, Hermann P, López-Pérez Ó, Andrés-Benito P, Ladogana A, Calero M, Vidal E, Riggert J, Pineau H, Sim V, et al. TREM2 expression in the brain and biological fluids in prion diseases. Acta Neuropathologica. PMID 33881612 DOI: 10.1007/s00401-021-02296-1   
2021 Galán-Ganga M, Rodríguez-Cueto C, Merchán-Rubira J, Hernández F, Ávila J, Posada-Ayala M, Lanciego JL, Luengo E, Lopez MG, Rábano A, Fernández-Ruiz J, Lastres-Becker I. Cannabinoid receptor CB2 ablation protects against TAU induced neurodegeneration. Acta Neuropathologica Communications. 9: 90. PMID 34001284 DOI: 10.1186/s40478-021-01196-5   
2021 Chen Y, Zhou J, Wang L. Role and Mechanism of Gut Microbiota in Human Disease. Frontiers in Cellular and Infection Microbiology. 11: 625913. PMID 33816335 DOI: 10.3389/fcimb.2021.625913   
2021 Yang X, Wang B, Hoop CL, Williams JK, Baum J. NMR unveils an N-terminal interaction interface on acetylated-α-synuclein monomers for recruitment to fibrils. Proceedings of the National Academy of Sciences of the United States of America. 118. PMID 33903234 DOI: 10.1073/pnas.2017452118   
2021 Iturria-Medina Y, Carbonell F, Assadi A, Adewale Q, Khan AF, Baumeister TR, Sanchez-Rodriguez L. Integrating molecular, histopathological, neuroimaging and clinical neuroscience data with NeuroPM-box. Communications Biology. 4: 614. PMID 34021244 DOI: 10.1038/s42003-021-02133-x   
2021 Scott GD, Lim MM, Drake MG, Woltjer R, Quinn JF. Onset of Skin, Gut, and Genitourinary Prodromal Parkinson's Disease: A Study of 1.5 Million Veterans. Movement Disorders : Official Journal of the Movement Disorder Society. PMID 33942370 DOI: 10.1002/mds.28636   
2021 Bahbah EI, Ghozy S, Attia MS, Negida A, Emran TB, Mitra S, Albadrani GM, Abdel-Daim MM, Uddin MS, Simal-Gandara J. Molecular Mechanisms of Astaxanthin as a Potential Neurotherapeutic Agent. Marine Drugs. 19. PMID 33916730 DOI: 10.3390/md19040201   
2021 Liang X, Hou X, Fang H. Structure, Function and Modulation of Striatal-enriched Protein Tyrosine Phosphatase (STEP). Current Medicinal Chemistry. PMID 33845719 DOI: 10.2174/0929867328666210412123304