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Brian S. Safina, Ph.D. - Publications

Affiliations: 
2004 University of California, San Diego, La Jolla, CA 
Area:
Organic Chemistry
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14 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2018 Chen H, Volgraf M, Do S, Kolesnikov A, Shore DG, Verma VA, Villemure E, Wang L, Chen Y, Hu B, Lu AJ, Wu G, Xu X, Yuen PW, Zhang Y, ... ... Safina BS, et al. Discovery of a Potent (4R,5S)-4-Fluoro-5-Methylproline Sulfonamide Transient Receptor Potential Ankyrin 1 (TRPA1) Antagonist and its Methylene Phosphate Prodrug Guided By Molecular Modeling. Journal of Medicinal Chemistry. PMID 29590749 DOI: 10.1021/Acs.Jmedchem.8B00117  0.642
2013 Carrera DE, Sheng P, Safina BS, Li J, Angelaud R. Development of a scalable strategy for the synthesis of PI3Kδ inhibitors: Selective and efficient functionalization of purine derivatives Organic Process Research and Development. 17: 138-144. DOI: 10.1021/Op300235T  0.349
2005 Nicolaou KC, Zak M, Safina BS, Estrada AA, Lee SH, Nevalainen M. Total synthesis of thiostrepton. Assembly of key building blocks and completion of the synthesis Journal of the American Chemical Society. 127: 11176-11183. PMID 16076225 DOI: 10.1021/Ja052934Z  0.77
2005 Nicolaou KC, Safina BS, Zak M, Lee SH, Nevalainen M, Bella M, Estrada AA, Funke C, Zécri FJ, Bulat S. Total synthesis of thiostrepton. Retrosynthetic analysis and construction of key building blocks. Journal of the American Chemical Society. 127: 11159-75. PMID 16076224 DOI: 10.1021/Ja0529337  0.763
2005 Nicolaou KC, Estrada AA, Zak M, Lee SH, Safina BS. A mild and selective method for the hydrolysis of esters with trimethyltin hydroxide Angewandte Chemie - International Edition. 44: 1378-1382. PMID 15674985 DOI: 10.1002/Anie.200462207  0.694
2005 Nicolaou K, Safina B, Zak M, Lee S, Navalainen M, Bella M, Estrada A, Funke C, Zecri F, Bulat S. Synthesis of Thiostrepton Synfacts. 2006: 0014-0014. DOI: 10.1055/S-2005-921667  0.757
2004 Nicolaou KC, Safina BS, Zak M, Estrada AA, Lee SH. Total synthesis of thiostrepton, part 1: construction of the dehydropiperidine/thiazoline-containing macrocycle. Angewandte Chemie (International Ed. in English). 43: 5087-92. PMID 15372631 DOI: 10.1002/Anie.200461340  0.78
2004 Nicolaou KC, Zak M, Safina BS, Lee SH, Estrada AA. Total synthesis of thiostrepton, part 2: construction of the quinaldic acid macrocycle and final stages of the synthesis. Angewandte Chemie (International Ed. in English). 43: 5092-7. PMID 15372630 DOI: 10.1002/Anie.200461341  0.77
2003 Nicolaou KC, Nevalainen M, Zak M, Bulat S, Bella M, Safina BS. Synthetic studies on thiostrepton: construction of thiostrepton analogues with the thiazoline-containing macrocycle. Angewandte Chemie (International Ed. in English). 42: 3418-24. PMID 12888975 DOI: 10.1002/Anie.200351745  0.759
2002 Nicolaou KC, Nevalainen M, Safina BS, Zak M, Bulat S. A biomimetically inspired synthesis of the dehydropiperidine domain of thiostrepton. Angewandte Chemie (International Ed. in English). 41: 1941-5. PMID 19750640 DOI: 10.1002/1521-3773(20020603)41:11<1941::Aid-Anie1941>3.0.Co;2-V  0.71
2002 Nicolaou KC, Safina BS, Funke C, Zak M, Zécri FJ. Stereocontrolled synthesis of the quinaldic acid macrocyclic system of thiostrepton. Angewandte Chemie (International Ed. in English). 41: 1937-40. PMID 19750639 DOI: 10.1002/1521-3773(20020603)41:11<1937::Aid-Anie1937>3.0.Co;2-Y  0.752
2002 Nicolaou KC, Nevalainen M, Safina BS, Zak M, Bulat S. A Biomimetically Inspired Synthesis of the Dehydropiperidine Domain of Thiostrepton We thank Drs. D. H. Huang and L. Pasternack, G. Suizdak, and R. Chadja for NMR spectroscopic, mass spectrometric, and X-ray crystallographic assistance, respectively. Financial support for this work was provided by The Skaggs Institute for Chemical Biology, the National Institutes of Health (USA), fellowships from The Academy of Finland (M.N.), The Skaggs Institute for Research (M.Z.), and Bayer AG (S.B.), and grants from Abbott, Amgen, Array Biopharma, Boehringer-Ingelheim, Glaxo, Hoffmann-LaRoche, DuPont, Merck, Novartis, Pfizer, and Schering Plough. Angewandte Chemie International Edition. 41: 1941. DOI: 10.1002/1521-3773(20020603)41:11<1941::AID-ANIE1941>3.0.CO;2-V  0.3
2002 Nicolaou KC, Safina BS, Funke C, Zak M, Zécri FJ. Stereocontrolled Synthesis of the Quinaldic Acid Macrocyclic System of Thiostrepton We thank Drs. D. H. Huang and G. Suizdak for NMR spectroscopic and mass spectrometric assistance, respectively, as well as Mike Sertic (University of California, San Diego) for experimental assistance. Financial support for this work was provided by The Skaggs Institute for Chemical Biology, the National Institutes of Health (USA), fellowships from The Skaggs Institute for Research (to M.Z. and F.Z.), and grants from Abbott, Amgen, Array Biopharma, Boehringer-Ingelheim, Glaxo, Hoffmann-LaRoche, DuPont, Merck, Novartis, Pfizer, and Schering Plough. Angewandte Chemie International Edition. 41: 1937. DOI: 10.1002/1521-3773(20020603)41:11<1937::AID-ANIE1937>3.0.CO;2-Y  0.334
2001 Nicolaou KC, Safina BS, Winssinger N. A new photolabile linker for the photoactivation of carboxyl groups Synlett. 900-903.  0.462
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