Emer M. Smyth, Ph.D. - Publications

Affiliations: 
University of Pennsylvania, Philadelphia, PA, United States 

42 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2018 Garg R, Blando JM, Perez CJ, Lal P, Feldman MD, Smyth EM, Ricciotti E, Grosser T, Benavides F, Kazanietz MG. COX-2 mediates pro-tumorigenic effects of PKCε in prostate cancer. Oncogene. PMID 29765153 DOI: 10.1038/s41388-018-0318-9  0.4
2014 Markosyan N, Chen EP, Smyth EM. Targeting COX-2 abrogates mammary tumorigenesis: Breaking cancer-associated suppression of immunosurveillance. Oncoimmunology. 3: e29287. PMID 25114833 DOI: 10.4161/onci.29287  1
2014 Mao Y, Li X, Smyth EM, Yannarell AC, Mackie RI. Enrichment of specific bacterial and eukaryotic microbes in the rhizosphere of switchgrass (Panicum virgatum L.) through root exudates. Environmental Microbiology Reports. 6: 293-306. PMID 24983534 DOI: 10.1111/1758-2229.12152  0.4
2014 Khan A, Li D, Ibrahim S, Smyth E, Woulfe DS. The physical association of the P2Y12 receptor with PAR4 regulates arrestin-mediated akt activation Molecular Pharmacology. 86: 1-11. PMID 24723492 DOI: 10.1124/mol.114.091595  1
2014 Chen EP, Markosyan N, Connolly E, Lawson JA, Li X, Grant GR, Grosser T, FitzGerald GA, Smyth EM. Myeloid Cell COX-2 deletion reduces mammary tumor growth through enhanced cytotoxic T-lymphocyte function. Carcinogenesis. 35: 1788-97. PMID 24590894 DOI: 10.1093/carcin/bgu053  1
2013 Markosyan N, Chen EP, Evans RA, Ndong V, Vonderheide RH, Smyth EM. Mammary carcinoma cell derived cyclooxygenase 2 suppresses tumor immune surveillance by enhancing intratumoral immune checkpoint activity. Breast Cancer Research : Bcr. 15: R75. PMID 24004819 DOI: 10.1186/bcr3469  1
2013 Frey AJ, Ibrahim S, Gleim S, Hwa J, Smyth EM. Biased suppression of TP homodimerization and signaling through disruption of a TM GxxxGxxxL helical interaction motif. Journal of Lipid Research. 54: 1678-90. PMID 23493750 DOI: 10.1194/jlr.M036673  1
2013 Siangjong L, Gauthier KM, Pfister SL, Smyth EM, Campbell WB. Endothelial 12(S)-HETE vasorelaxation is mediated by thromboxane receptor inhibition in mouse mesenteric arteries. American Journal of Physiology. Heart and Circulatory Physiology. 304: H382-92. PMID 23203967 DOI: 10.1152/ajpheart.00690.2012  1
2013 Ibrahim S, McCartney A, Markosyan N, Smyth EM. Heterodimerization with the prostacyclin receptor triggers thromboxane receptor relocation to lipid rafts. Arteriosclerosis, Thrombosis, and Vascular Biology. 33: 60-6. PMID 23162015 DOI: 10.1161/ATVBAHA.112.300536  1
2011 Chen EP, Smyth EM. COX-2 and PGE2-dependent immunomodulation in breast cancer. Prostaglandins & Other Lipid Mediators. 96: 14-20. PMID 21907301 DOI: 10.1016/j.prostaglandins.2011.08.005  1
2011 Markosyan N, Chen EP, Ndong VN, Yao Y, Sterner CJ, Chodosh LA, Lawson JA, Fitzgerald GA, Smyth EM. Deletion of cyclooxygenase 2 in mouse mammary epithelial cells delays breast cancer onset through augmentation of type 1 immune responses in tumors. Carcinogenesis. 32: 1441-9. PMID 21771729 DOI: 10.1093/carcin/bgr134  1
2010 Smyth EM. Thromboxane and the thromboxane receptor in cardiovascular disease. Clinical Lipidology. 5: 209-219. PMID 20543887 DOI: 10.2217/clp.10.11  1
2010 Ibrahim S, Tetruashvily M, Frey AJ, Wilson SJ, Stitham J, Hwa J, Smyth EM. Dominant negative actions of human prostacyclin receptor variant through dimerization: implications for cardiovascular disease. Arteriosclerosis, Thrombosis, and Vascular Biology. 30: 1802-9. PMID 20522800 DOI: 10.1161/ATVBAHA.110.208900  1
2010 Yu Y, Stubbe J, Ibrahim S, Song WL, Smyth EM, Symth EM, Funk CD, FitzGerald GA. Cyclooxygenase-2-dependent prostacyclin formation and blood pressure homeostasis: targeted exchange of cyclooxygenase isoforms in mice. Circulation Research. 106: 337-45. PMID 19940265 DOI: 10.1161/CIRCRESAHA.109.204529  1
2010 Smyth EM, FitzGerald GA. Prostaglandin mediators Handbook of Cell Signaling, 2/E. 2: 1219-1228. DOI: 10.1016/B978-0-12-374145-5.00150-9  1
2009 McGillicuddy FC, Chiquoine EH, Hinkle CC, Kim RJ, Shah R, Roche HM, Smyth EM, Reilly MP. Interferon gamma attenuates insulin signaling, lipid storage, and differentiation in human adipocytes via activation of the JAK/STAT pathway. The Journal of Biological Chemistry. 284: 31936-44. PMID 19776010 DOI: 10.1074/jbc.M109.061655  1
2009 Yu Y, Lucitt MB, Stubbe J, Cheng Y, Friis UG, Hansen PB, Jensen BL, Smyth EM, FitzGerald GA. Prostaglandin F2alpha elevates blood pressure and promotes atherosclerosis. Proceedings of the National Academy of Sciences of the United States of America. 106: 7985-90. PMID 19416858 DOI: 10.1073/pnas.0811834106  1
2009 Wilson SJ, Cavanagh CC, Lesher AM, Frey AJ, Russell SE, Smyth EM. Activation-dependent stabilization of the human thromboxane receptor: role of reactive oxygen species. Journal of Lipid Research. 50: 1047-56. PMID 19151335 DOI: 10.1194/jlr.M800447-JLR200  1
2009 Smyth EM, Grosser T, Wang M, Yu Y, FitzGerald GA. Prostanoids in health and disease. Journal of Lipid Research. 50: S423-8. PMID 19095631 DOI: 10.1194/jlr.R800094-JLR200  1
2007 Wada M, DeLong CJ, Hong YH, Rieke CJ, Song I, Sidhu RS, Yuan C, Warnock M, Schmaier AH, Yokoyama C, Smyth EM, Wilson SJ, FitzGerald GA, Garavito RM, Sui de X, et al. Enzymes and receptors of prostaglandin pathways with arachidonic acid-derived versus eicosapentaenoic acid-derived substrates and products. The Journal of Biological Chemistry. 282: 22254-66. PMID 17519235 DOI: 10.1074/jbc.M703169200  1
2007 Wilson SJ, McGinley K, Huang AJ, Smyth EM. Heterodimerization of the alpha and beta isoforms of the human thromboxane receptor enhances isoprostane signaling. Biochemical and Biophysical Research Communications. 352: 397-403. PMID 17134677 DOI: 10.1016/j.bbrc.2006.11.040  1
2007 Wilson SJ, Dowling JK, Zhao L, Carnish E, Smyth EM. Regulation of thromboxane receptor trafficking through the prostacyclin receptor in vascular smooth muscle cells: role of receptor heterodimerization. Arteriosclerosis, Thrombosis, and Vascular Biology. 27: 290-6. PMID 17110599 DOI: 10.1161/01.ATV.0000252667.53790.4e  1
2006 Wilson SJ, Smyth EM. Internalization and recycling of the human prostacyclin receptor is modulated through its isoprenylation-dependent interaction with the delta subunit of cGMP phosphodiesterase 6. The Journal of Biological Chemistry. 281: 11780-6. PMID 16527812 DOI: 10.1074/jbc.M513110200  1
2006 Zhang L, DiLizio C, Kim D, Smyth EM, Manning DR. The G12 family of G proteins as a reporter of thromboxane A2 receptor activity. Molecular Pharmacology. 69: 1433-40. PMID 16418336 DOI: 10.1124/mol.105.019703  1
2004 Egan KM, Lawson JA, Fries S, Koller B, Rader DJ, Smyth EM, Fitzgerald GA. COX-2-derived prostacyclin confers atheroprotection on female mice. Science (New York, N.Y.). 306: 1954-7. PMID 15550624 DOI: 10.1126/science.1103333  1
2004 Wilson SJ, Roche AM, Kostetskaia E, Smyth EM. Dimerization of the human receptors for prostacyclin and thromboxane facilitates thromboxane receptor-mediated cAMP generation. The Journal of Biological Chemistry. 279: 53036-47. PMID 15471868 DOI: 10.1074/jbc.M405002200  1
2004 Curtis AM, Seo SB, Westgate EJ, Rudic RD, Smyth EM, Chakravarti D, FitzGerald GA, McNamara P. Histone acetyltransferase-dependent chromatin remodeling and the vascular clock. The Journal of Biological Chemistry. 279: 7091-7. PMID 14645221 DOI: 10.1074/jbc.M311973200  1
2003 Kothapalli D, Stewart SA, Smyth EM, Azonobi I, Pure E, Assoian RK. Prostacylin receptor activation inhibits proliferation of aortic smooth muscle cells by regulating cAMP response element-binding protein- and pocket protein-dependent cyclin a gene expression. Molecular Pharmacology. 64: 249-58. PMID 12869629 DOI: 10.1124/mol.64.2.249  1
2002 Smyth EM, Austin SC, FitzGerald GA. Activation-dependent internalization of the human prostacyclin receptor. Advances in Experimental Medicine and Biology. 507: 295-301. PMID 12664600  1
2002 Smyth EM, FitzGerald GA. Human prostacyclin receptor. Vitamins and Hormones. 65: 149-65. PMID 12481546  1
2001 Zhang Z, Austin SC, Smyth EM. Glycosylation of the human prostacyclin receptor: role in ligand binding and signal transduction. Molecular Pharmacology. 60: 480-7. PMID 11502878  1
2000 Smyth EM, Austin SC, Reilly MP, FitzGerald GA. Internalization and sequestration of the human prostacyclin receptor. The Journal of Biological Chemistry. 275: 32037-45. PMID 10889200 DOI: 10.1074/jbc.M003873200  1
1998 Smyth EM, Li WH, FitzGerald GA. Phosphorylation of the prostacyclin receptor during homologous desensitization. A critical role for protein kinase c. The Journal of Biological Chemistry. 273: 23258-66. PMID 9722557 DOI: 10.1074/jbc.273.36.23258  1
1997 Smyth EM, Fitzgerald GA. Identification of the site for pkc-dependent phosphorylation of the human prostacyclin receptor Faseb Journal. 11: A1054.  1
1996 Smyth EM, Nestor PV, FitzGerald GA. Agonist-dependent phosphorylation of an epitope-tagged human prostacyclin receptor. The Journal of Biological Chemistry. 271: 33698-704. PMID 8969241 DOI: 10.1074/jbc.271.52.33698  1
1996 McQuaid KE, Smyth EM, Keenan AK. Evidence for modulation of hydrogen peroxide-induced endothelial barrier dysfunction by nitric oxide in vitro. European Journal of Pharmacology. 307: 233-41. PMID 8832226 DOI: 10.1016/0014-2999(96)00271-3  1
1996 Praticò D, Smyth EM, Violi F, FitzGerald GA. Local amplification of platelet function by 8-Epi prostaglandin F2alpha is not mediated by thromboxane receptor isoforms. The Journal of Biological Chemistry. 271: 14916-24. PMID 8663015  1
1994 Smyth EM, Keenan AK. Effects of the ANF-C receptor ligand des[Cys105,Cys121]rANF(104-126) on ANF internalization and cGMP production by bovine pulmonary artery endothelial cells. Life Sciences. 54: 1-7. PMID 8255164 DOI: 10.1016/0024-3205(94)00571-0  1
1994 Smyth EM, Keenan AK. The vascular ANF-C receptor: role in atrial peptide signalling. Cellular Signalling. 6: 125-33. PMID 8086274 DOI: 10.1016/0898-6568(94)90068-X  1
1992 Barniville G, Hartigan PJ, Lydon A, Rawas O, Andrews JF, Donne B, Kelly M, Brady C, McNamara B, Taylor D, Ishtiaq A, Glacken P, O'brien M, Moraes D, Tyrrell J, ... ... Smyth EM, et al. Royal academy of medicine in Ireland section of biomedical sciences - Proceedings of meeting held 23rd and 24th June, 1992 Irish Journal of Medical Science. 161: 639-652. DOI: 10.1007/BF02983772  1
1992 Bourke W, O'Connor C, Fitzgerald MX, McConnell TJ, Kent A, Redmond EM, Keenan AK, Smyth EM, Shanahan R, O'Donnell N, O'Connor CM, Kelly V, Barry-Kinsella C, Sharma SC, Cottrell E, et al. Royal academy of medicine in ireland section of biological sciences - Proceedings of winter meeting held friday, 3rd January, 1992 in R.C.S.I. Irish Journal of Medical Science. 161: 463-473. DOI: 10.1007/BF02942159  1
1992 Smyth E, Redmond EM, Fenton M, Keenan AK. Neutral endopeptidase does not affect atrial natriuretic factor-stimulated cyclic guanine monophosphate production in bovine pulmonary artery endothelial cells European Journal of Internal Medicine. 2: 285-287.  1
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