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Garret A. FitzGerald, M.D. - Publications

Affiliations: 
University of Pennsylvania, Philadelphia, PA, United States 
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Year Citation  Score
2023 Meng H, Sengupta A, Ricciotti E, Mrčela A, Mathew D, Mazaleuskaya LL, Ghosh S, Brooks TG, Turner AP, Schanoski AS, Lahens NF, Tan AW, Woolfork A, Grant G, Susztak K, ... ... FitzGerald GA, et al. Deep phenotyping of the lipidomic response in COVID-19 and non-COVID-19 sepsis. Clinical and Translational Medicine. 13: e1440. PMID 37948331 DOI: 10.1002/ctm2.1440  0.517
2023 Meng H, Sengupta A, Ricciotti E, Mrčela A, Mathew D, Mazaleuskaya LL, Ghosh S, Brooks TG, Turner AP, Schanoski AS, Lahens NF, Tan AW, Woolfork A, Grant G, Susztak K, ... ... FitzGerald GA, et al. Deep Phenotyping of the Lipidomic Response in COVID and non-COVID Sepsis. Biorxiv : the Preprint Server For Biology. PMID 37398323 DOI: 10.1101/2023.06.02.543298  0.551
2023 Anderson ST, Meng H, Brooks TG, Tang SY, Lordan R, Sengupta A, Nayak S, Mřela A, Sarantopoulou D, Lahens NF, Weljie A, Grant GR, Bushman FD, FitzGerald GA. Sexual dimorphism in the response to chronic circadian misalignment on a high-fat diet. Science Translational Medicine. 15: eabo2022. PMID 37196066 DOI: 10.1126/scitranslmed.abo2022  0.538
2023 Skarke C, Lordan R, Barekat K, Naik A, Mathew D, Ohtani T, Greenplate AR, Grant GR, Lahens NF, Gouma S, Troisi E, Sengupta A, Weljie AM, Meng W, Luning Prak ET, ... ... FitzGerald GA, et al. . The Journal of Pharmacology and Experimental Therapeutics. PMID 37105582 DOI: 10.1124/jpet.122.001415  0.526
2021 Lordan R, Prior S, Hennessy E, Naik A, Ghosh S, Paschos GK, Skarke C, Barekat K, Hollingsworth T, Juska S, Mazaleuskaya LL, Teegarden S, Glascock AL, Anderson S, Meng H, ... ... FitzGerald GA, et al. Considerations for the Safe Operation of Schools During the Coronavirus Pandemic. Frontiers in Public Health. 9: 751451. PMID 34976917 DOI: 10.3389/fpubh.2021.751451  0.51
2020 Yang G, Zhang J, Jiang T, Monslow J, Yew Tang S, Todd L, Puré E, Chen L, FitzGerald GA. Bmal1 (Brain and Muscle Aryl Hydrocarbon Receptor Nuclear-Like 1) Deletion in Myeloid Cells Attenuates Atherosclerotic Lesion Development and Restrains Abdominal Aortic Aneurysm Formation in Hyperlipidemic Mice. Arteriosclerosis, Thrombosis, and Vascular Biology. ATVBAHA120314318. PMID 32321308 DOI: 10.1161/Atvbaha.120.314318  0.309
2019 Ruben MD, Smith DF, FitzGerald GA, Hogenesch JB. Dosing time matters. Science (New York, N.Y.). 365: 547-549. PMID 31395773 DOI: 10.1126/Science.Aax7621  0.498
2019 Sacco A, Bruno A, Contursi A, Dovizio M, Tacconelli S, Ricciotti E, Guillem-Llobat P, Salvatore T, Di Francesco L, Fullone R, Ballerini P, Arena V, Alberti S, Liu G, Gong Y, ... ... FitzGerald G, et al. Platelet-specific deletion of cyclooxygenase-1 ameliorates dextran sulfate sodium-induced colitis in mice. The Journal of Pharmacology and Experimental Therapeutics. PMID 31248980 DOI: 10.1124/Jpet.119.259382  0.323
2018 Chen L, Yang G, Zhang J, Ren B, Tang S, Li X, FitzGerald GA. Time-Dependent Hypotensive Effect of Aspirin in Mice. Arteriosclerosis, Thrombosis, and Vascular Biology. 38: 2819-2826. PMID 30571171 DOI: 10.1161/Atvbaha.118.311296  0.333
2018 Elling R, Robinson EK, Shapleigh B, Liapis SC, Covarrubias S, Katzman S, Groff AF, Jiang Z, Agarwal S, Motwani M, Chan J, Sharma S, Hennessy EJ, FitzGerald GA, McManus MT, et al. Genetic Models Reveal cis and trans Immune-Regulatory Activities for lincRNA-Cox2. Cell Reports. 25: 1511-1524.e6. PMID 30404006 DOI: 10.1016/J.Celrep.2018.10.027  0.301
2018 Ricciotti E, Castro C, Tang SY, Briggs WTE, West JA, Malik D, Rhoades SD, Meng H, Li X, Lahens NF, Sparks JA, Karlson EW, Weljie AM, Griffin JL, FitzGerald GA. Cyclooxygenase-2, Asymmetric Dimethylarginine and the Cardiovascular Hazard from NSAIDs. Circulation. PMID 29930022 DOI: 10.1161/Circulationaha.118.033540  0.607
2018 Ocana JA, Romer E, Sahu R, Pawelzik SC, FitzGerald GA, Kaplan MH, Travers JB. Platelet-Activating Factor-Induced Reduction in Contact Hypersensitivity Responses Is Mediated by Mast Cells via Cyclooxygenase-2-Dependent Mechanisms. Journal of Immunology (Baltimore, Md. : 1950). PMID 29695417 DOI: 10.4049/Jimmunol.1701145  0.315
2017 Skarke C, Lahens NF, Rhoades SD, Campbell A, Bittinger K, Bailey A, Hoffmann C, Olson RS, Chen L, Yang G, Price TS, Moore JH, Bushman FD, Greene CS, Grant GR, ... ... FitzGerald GA, et al. A Pilot Characterization of the Human Chronobiome. Scientific Reports. 7: 17141. PMID 29215023 DOI: 10.1038/S41598-017-17362-6  0.726
2017 Li X, Mazaleuskaya LL, Yuan C, Ballantyne LL, Meng H, Smith WL, FitzGerald GA, Funk CD. Flipping the Cyclooxygenase (Ptgs) Genes Reveals Isoform-Specific Compensatory Functions. Journal of Lipid Research. PMID 29180445 DOI: 10.1194/Jlr.M079996  0.333
2017 Li X, Mazaleuskaya LL, Ballantyne LL, Meng H, FitzGerald GA, Funk CD. Genomic and lipidomic analyses differentiate the compensatory roles of two cyclooxygenase isoforms during systemic inflammation in mice. Journal of Lipid Research. PMID 29180443 DOI: 10.1194/Jlr.M080028  0.317
2017 Hughes ME, Abruzzi KC, Allada R, Anafi R, Arpat AB, Asher G, Baldi P, de Bekker C, Bell-Pedersen D, Blau J, Brown S, Ceriani MF, Chen Z, Chiu JC, Cox J, ... ... FitzGerald GA, et al. Guidelines for Genome-Scale Analysis of Biological Rhythms. Journal of Biological Rhythms. 748730417728663. PMID 29098954 DOI: 10.1177/0748730417728663  0.527
2016 FitzGerald GA. ImPRECISION: Limitations to Interpretation of a Large Randomized Clinical Trial. Circulation. PMID 27840335 DOI: 10.1161/Circulationaha.116.026324  0.302
2016 Tang SY, Monslow J, Grant GR, Todd L, Pawelzik SC, Chen L, Lawson J, Puré E, FitzGerald GA. Cardiovascular Consequences of Prostanoid I Receptor Deletion in Microsomal Prostaglandin E Synthase-1 Deficient Hyperlipidemic Mice. Circulation. PMID 27440004 DOI: 10.1161/Circulationaha.116.022308  0.312
2016 Guillem-Llobat P, Dovizio M, Bruno A, Ricciotti E, Cufino V, Sacco A, Grande R, Alberti S, Arena V, Cirillo M, Patrono C, FitzGerald GA, Steinhilber D, Sgambato A, Patrignani P. Aspirin prevents colorectal cancer metastasis in mice by splitting the crosstalk between platelets and tumor cells. Oncotarget. PMID 27074574 DOI: 10.18632/Oncotarget.8655  0.307
2016 Kim EJ, Lahens N, Ricciotti E, Manduchi E, Grosser T, Fitzgerald G, Hogenesch J, Grant G. Resampling-based read-level normalization of RNA-Seq for differential expression analysis F1000research. 5. DOI: 10.7490/F1000Research.1112772.1  0.503
2015 Fitzgerald GA, Yang G, Paschos GK, Liang X, Skarke C. Molecular clocks and the human condition: approaching their characterization in human physiology and disease. Diabetes, Obesity & Metabolism. 17: 139-42. PMID 26332979 DOI: 10.1111/Dom.12526  0.302
2015 Markosyan N, Rech A, Vonderheide RH, FitzGerald GA, Smyth EM. Abstract 469: mPGES1 deletion and the mechanisms of tumor growth suppression Cancer Research. 75: 469-469. DOI: 10.1158/1538-7445.Am2015-469  0.569
2014 Li X, Fries S, Li R, Lawson JA, Propert KJ, Diamond SL, Blair IA, FitzGerald GA, Grosser T. Differential impairment of aspirin-dependent platelet cyclooxygenase acetylation by nonsteroidal antiinflammatory drugs. Proceedings of the National Academy of Sciences of the United States of America. 111: 16830-5. PMID 25385584 DOI: 10.1073/Pnas.1406997111  0.302
2014 Chen L, Yang G, Monslow J, Todd L, Cormode DP, Tang J, Grant GR, DeLong JH, Tang SY, Lawson JA, Pure E, Fitzgerald GA. Myeloid cell microsomal prostaglandin E synthase-1 fosters atherogenesis in mice. Proceedings of the National Academy of Sciences of the United States of America. 111: 6828-33. PMID 24753592 DOI: 10.1073/Pnas.1401797111  0.311
2014 Chen EP, Markosyan N, Connolly E, Lawson JA, Li X, Grant GR, Grosser T, FitzGerald GA, Smyth EM. Myeloid Cell COX-2 deletion reduces mammary tumor growth through enhanced cytotoxic T-lymphocyte function. Carcinogenesis. 35: 1788-97. PMID 24590894 DOI: 10.1093/Carcin/Bgu053  0.672
2014 Tragante V, Barnes MR, Ganesh SK, Lanktree MB, Guo W, Franceschini N, Smith EN, Johnson T, Holmes MV, Padmanabhan S, Karczewski KJ, Almoguera B, Barnard J, Baumert J, Chang YP, ... ... FitzGerald GA, et al. Gene-centric meta-analysis in 87,736 individuals of European ancestry identifies multiple blood-pressure-related loci. American Journal of Human Genetics. 94: 349-60. PMID 24560520 DOI: 10.1016/J.Ajhg.2013.12.016  0.61
2014 Tang SY, Monslow J, Todd L, Lawson J, Puré E, FitzGerald GA. Cyclooxygenase-2 in endothelial and vascular smooth muscle cells restrains atherogenesis in hyperlipidemic mice. Circulation. 129: 1761-9. PMID 24519928 DOI: 10.1161/Circulationaha.113.007913  0.311
2014 Holmes MV, Lange LA, Palmer T, Lanktree MB, North KE, Almoguera B, Buxbaum S, Chandrupatla HR, Elbers CC, Guo Y, Hoogeveen RC, Li J, Li YR, Swerdlow DI, Cushman M, ... ... FitzGerald GA, et al. Causal effects of body mass index on cardiometabolic traits and events: a Mendelian randomization analysis. American Journal of Human Genetics. 94: 198-208. PMID 24462370 DOI: 10.1016/J.Ajhg.2013.12.014  0.593
2014 Holmes M, Lange L, Palmer T, Lanktree M, North K, Almoguera B, Buxbaum S, Chandrupatla H, Elbers C, Guo Y, Hoogeveen R, Li J, Li Y, Swerdlow D, Cushman M, ... ... FitzGerald G, et al. Causal Effects of Body Mass Index on Cardiometabolic Traits and Events: A Mendelian Randomization Analysis The American Journal of Human Genetics. 94: 312. DOI: 10.1016/J.Ajhg.2014.01.012  0.578
2013 Musiek ES, Lim MM, Yang G, Bauer AQ, Qi L, Lee Y, Roh JH, Ortiz-Gonzalez X, Dearborn JT, Culver JP, Herzog ED, Hogenesch JB, Wozniak DF, Dikranian K, Giasson BI, ... ... Fitzgerald GA, et al. Circadian clock proteins regulate neuronal redox homeostasis and neurodegeneration. The Journal of Clinical Investigation. 123: 5389-400. PMID 24270424 DOI: 10.1172/Jci70317  0.544
2013 Curtis AM, FitzGerald GA. Platelet microRNAs: Novy Mir* or mired in human complexity? Circulation Research. 112: 576-8. PMID 23410874 DOI: 10.1161/Circresaha.113.300859  0.319
2013 Ganesh SK, Tragante V, Guo W, Guo Y, Lanktree MB, Smith EN, Johnson T, Castillo BA, Barnard J, Baumert J, Chang YP, Elbers CC, Farrall M, Fischer ME, Franceschini N, ... ... Fitzgerald GA, et al. Loci influencing blood pressure identified using a cardiovascular gene-centric array. Human Molecular Genetics. 22: 1663-78. PMID 23303523 DOI: 10.1093/Hmg/Dds555  0.603
2013 Yu Z, Ricciotti E, Miwa T, Liu S, Ihida-Stansbury K, Landersberg G, Jones PL, Scalia R, Song WC, Assoian RK, FitzGerald GA. Myeloid cell 5-lipoxygenase activating protein modulates the response to vascular injury. Circulation Research. 112: 432-40. PMID 23250985 DOI: 10.1161/Circresaha.112.300755  0.473
2012 Yang G, FitzGerald GA. (Almost) everything is illuminated: adenosine shines a light on cardioprotection. Circulation Research. 111: 965-6. PMID 23023508 DOI: 10.1161/Circresaha.112.279752  0.303
2012 Yu Y, Ricciotti E, Scalia R, Tang SY, Grant G, Yu Z, Landesberg G, Crichton I, Wu W, Puré E, Funk CD, FitzGerald GA. Vascular COX-2 modulates blood pressure and thrombosis in mice. Science Translational Medicine. 4: 132ra54. PMID 22553252 DOI: 10.1126/Scitranslmed.3003787  0.523
2012 Yu Z, Crichton I, Tang SY, Hui Y, Ricciotti E, Levin MD, Lawson JA, Puré E, FitzGerald GA. Disruption of the 5-lipoxygenase pathway attenuates atherogenesis consequent to COX-2 deletion in mice. Proceedings of the National Academy of Sciences of the United States of America. 109: 6727-32. PMID 22493243 DOI: 10.1073/Pnas.1115313109  0.509
2012 Song WL, Stubbe J, Ricciotti E, Alamuddin N, Ibrahim S, Crichton I, Prempeh M, Lawson JA, Wilensky RL, Rasmussen LM, Puré E, FitzGerald GA. Niacin and biosynthesis of PGDâ‚‚by platelet COX-1 in mice and humans. The Journal of Clinical Investigation. 122: 1459-68. PMID 22406532 DOI: 10.1172/Jci59262  0.343
2012 Saxena R, Elbers CC, Guo Y, Peter I, Gaunt TR, Mega JL, Lanktree MB, Tare A, Castillo BA, Li YR, Johnson T, Bruinenberg M, Gilbert-Diamond D, Rajagopalan R, Voight BF, ... ... FitzGerald GA, et al. Large-scale gene-centric meta-analysis across 39 studies identifies type 2 diabetes loci. American Journal of Human Genetics. 90: 410-25. PMID 22325160 DOI: 10.1016/J.Ajhg.2011.12.022  0.595
2012 Skarke C, Alamuddin N, Lawson JA, Cen L, Propert KJ, Fitzgerald GA. Comparative impact on prostanoid biosynthesis of celecoxib and the novel nonsteroidal anti-inflammatory drug CG100649. Clinical Pharmacology and Therapeutics. 91: 986-93. PMID 22278334 DOI: 10.1038/Clpt.2012.3  0.306
2012 Dovizio M, Tacconelli S, Ricciotti E, Bruno A, Maier TJ, Anzellotti P, Di Francesco L, Sala P, Signoroni S, Bertario L, Dixon DA, Lawson JA, Steinhilber D, FitzGerald GA, Patrignani P. Effects of celecoxib on prostanoid biosynthesis and circulating angiogenesis proteins in familial adenomatous polyposis. The Journal of Pharmacology and Experimental Therapeutics. 341: 242-50. PMID 22262921 DOI: 10.1124/Jpet.111.190785  0.326
2012 Lanktree M, Guo Y, Murtaza M, Glessner J, Bailey S, Onland-Moret N, Lettre G, Ongen H, Rajagopalan R, Johnson T, Shen H, Nelson C, Klopp N, Baumert J, Padmanabhan S, ... ... FitzGerald G, et al. Meta-analysis of Dense Genecentric Association Studies Reveals Common and Uncommon Variants Associated with Height The American Journal of Human Genetics. 90: 1116-1117. DOI: 10.1016/J.Ajhg.2012.05.017  0.576
2012 Saxena R, Elbers C, Guo Y, Peter I, Gaunt T, Mega J, Lanktree M, Tare A, Castillo B, Li Y, Johnson T, Bruinenberg M, Gilbert-Diamond D, Rajagopalan R, Voight B, ... ... FitzGerald G, et al. Large-Scale Gene-Centric Meta-Analysis across 39 Studies Identifies Type 2 Diabetes Loci The American Journal of Human Genetics. 90: 753. DOI: 10.1016/J.Ajhg.2012.03.001  0.578
2011 Markosyan N, Chen EP, Ndong VN, Yao Y, Sterner CJ, Chodosh LA, Lawson JA, Fitzgerald GA, Smyth EM. Deletion of cyclooxygenase 2 in mouse mammary epithelial cells delays breast cancer onset through augmentation of type 1 immune responses in tumors. Carcinogenesis. 32: 1441-9. PMID 21771729 DOI: 10.1093/Carcin/Bgr134  0.679
2011 Ricciotti E, FitzGerald GA. Prostaglandins and inflammation. Arteriosclerosis, Thrombosis, and Vascular Biology. 31: 986-1000. PMID 21508345 DOI: 10.1161/Atvbaha.110.207449  0.32
2011 Wang M, Ihida-Stansbury K, Kothapalli D, Tamby MC, Yu Z, Chen L, Grant G, Cheng Y, Lawson JA, Assoian RK, Jones PL, Fitzgerald GA. Microsomal prostaglandin e2 synthase-1 modulates the response to vascular injury. Circulation. 123: 631-9. PMID 21282500 DOI: 10.1161/Circulationaha.110.973685  0.489
2011 Lanktree MB, Guo Y, Murtaza M, Glessner JT, Bailey SD, Onland-Moret NC, Lettre G, Ongen H, Rajagopalan R, Johnson T, Shen H, Nelson CP, Klopp N, Baumert J, Padmanabhan S, ... ... Fitzgerald GA, et al. Meta-analysis of Dense Genecentric Association Studies Reveals Common and Uncommon Variants Associated with Height. American Journal of Human Genetics. 88: 6-18. PMID 21194676 DOI: 10.1016/J.Ajhg.2010.11.007  0.585
2010 Wang M, FitzGerald GA. Cardiovascular biology of microsomal prostaglandin E synthase-1. Trends in Cardiovascular Medicine. 20: 189-95. PMID 22137640 DOI: 10.1016/J.Tcm.2011.04.002  0.307
2010 Hui Y, Ricciotti E, Crichton I, Yu Z, Wang D, Stubbe J, Wang M, Puré E, FitzGerald GA. Targeted deletions of cyclooxygenase-2 and atherogenesis in mice. Circulation. 121: 2654-60. PMID 20530000 DOI: 10.1161/Circulationaha.109.910687  0.504
2010 Wang M, Cooper PR, Jiang M, Zhao H, Hui Y, Yao Y, Tate JC, Damera G, Lawson JA, Jester WF, Haczku A, Panettieri RA, FitzGerald GA. Deletion of microsomal prostaglandin E synthase-1 does not alter ozone-induced airway hyper-responsiveness. The Journal of Pharmacology and Experimental Therapeutics. 334: 63-8. PMID 20371706 DOI: 10.1124/Jpet.110.166678  0.304
2010 Paschos GK, Baggs JE, Hogenesch JB, FitzGerald GA. The role of clock genes in pharmacology. Annual Review of Pharmacology and Toxicology. 50: 187-214. PMID 20055702 DOI: 10.1146/Annurev.Pharmtox.010909.105621  0.545
2010 Yu Y, Stubbe J, Ibrahim S, Song WL, Smyth EM, Symth EM, Funk CD, FitzGerald GA. Cyclooxygenase-2-dependent prostacyclin formation and blood pressure homeostasis: targeted exchange of cyclooxygenase isoforms in mice. Circulation Research. 106: 337-45. PMID 19940265 DOI: 10.1161/Circresaha.109.204529  0.632
2010 Smyth EM, FitzGerald GA. Prostaglandin mediators Handbook of Cell Signaling, 2/E. 2: 1219-1228. DOI: 10.1016/B978-0-12-374145-5.00150-9  0.573
2009 Yu Y, Ricciotti E, Grosser T, Fitzgerald GA. The translational therapeutics of prostaglandin inhibition in atherothrombosis. Journal of Thrombosis and Haemostasis : Jth. 7: 222-6. PMID 19630805 DOI: 10.1111/J.1538-7836.2009.03439.X  0.328
2009 Grad E, Golomb M, Koroukhov N, Lawson JA, Lotan C, Fitzgerald GA, Danenberg HD. Aspirin reduces the prothrombotic activity of C-reactive protein. Journal of Thrombosis and Haemostasis : Jth. 7: 1393-400. PMID 19522741 DOI: 10.1111/J.1538-7836.2009.03511.X  0.335
2009 Yu Y, Lucitt MB, Stubbe J, Cheng Y, Friis UG, Hansen PB, Jensen BL, Smyth EM, FitzGerald GA. Prostaglandin F2alpha elevates blood pressure and promotes atherosclerosis. Proceedings of the National Academy of Sciences of the United States of America. 106: 7985-90. PMID 19416858 DOI: 10.1073/Pnas.0811834106  0.623
2009 Wang D, Patel VV, Ricciotti E, Zhou R, Levin MD, Gao E, Yu Z, Ferrari VA, Lu MM, Xu J, Zhang H, Hui Y, Cheng Y, Petrenko N, Yu Y, ... FitzGerald GA, et al. Cardiomyocyte cyclooxygenase-2 influences cardiac rhythm and function. Proceedings of the National Academy of Sciences of the United States of America. 106: 7548-52. PMID 19376970 DOI: 10.1073/Pnas.0805806106  0.481
2009 Baggs JE, Price TS, DiTacchio L, Panda S, Fitzgerald GA, Hogenesch JB. Network features of the mammalian circadian clock. Plos Biology. 7: e52. PMID 19278294 DOI: 10.1371/Journal.Pbio.1000052  0.695
2009 Smyth EM, Grosser T, Wang M, Yu Y, FitzGerald GA. Prostanoids in health and disease. Journal of Lipid Research. 50: S423-8. PMID 19095631 DOI: 10.1194/Jlr.R800094-Jlr200  0.603
2008 Keating BJ, Tischfield S, Murray SS, Bhangale T, Price TS, Glessner JT, Galver L, Barrett JC, Grant SF, Farlow DN, Chandrupatla HR, Hansen M, Ajmal S, Papanicolaou GJ, Guo Y, ... ... Fitzgerald GA, et al. Concept, design and implementation of a cardiovascular gene-centric 50 k SNP array for large-scale genomic association studies. Plos One. 3: e3583. PMID 18974833 DOI: 10.1371/Journal.Pone.0003583  0.606
2008 Price TS, Baggs JE, Curtis AM, Fitzgerald GA, Hogenesch JB. WAVECLOCK: wavelet analysis of circadian oscillation. Bioinformatics (Oxford, England). 24: 2794-5. PMID 18931366 DOI: 10.1093/Bioinformatics/Btn521  0.461
2008 Chen M, Boilard E, Nigrovic PA, Clark P, Xu D, Fitzgerald GA, Audoly LP, Lee DM. Predominance of cyclooxygenase 1 over cyclooxygenase 2 in the generation of proinflammatory prostaglandins in autoantibody-driven K/BxN serum-transfer arthritis. Arthritis and Rheumatism. 58: 1354-65. PMID 18438856 DOI: 10.1002/Art.23453  0.314
2008 Westgate EJ, Cheng Y, Reilly DF, Price TS, Walisser JA, Bradfield CA, FitzGerald GA. Genetic components of the circadian clock regulate thrombogenesis in vivo. Circulation. 117: 2087-95. PMID 18413500 DOI: 10.1161/Circulationaha.107.739227  0.624
2008 Wang M, Song WL, Cheng Y, Fitzgerald GA. Microsomal prostaglandin E synthase-1 inhibition in cardiovascular inflammatory disease. Journal of Internal Medicine. 263: 500-5. PMID 18410593 DOI: 10.1111/J.1365-2796.2008.01938.X  0.316
2008 Kunieda T, Minamino T, Miura K, Katsuno T, Tateno K, Miyauchi H, Kaneko S, Bradfield CA, FitzGerald GA, Komuro I. Reduced nitric oxide causes age-associated impairment of circadian rhythmicity. Circulation Research. 102: 607-14. PMID 18218984 DOI: 10.1161/Circresaha.107.162230  0.302
2008 Lucitt MB, Price TS, Pizarro A, Wu W, Yocum AK, Seiler C, Pack MA, Blair IA, Fitzgerald GA, Grosser T. Analysis of the zebrafish proteome during embryonic development. Molecular & Cellular Proteomics : McP. 7: 981-94. PMID 18212345 DOI: 10.1074/Mcp.M700382-Mcp200  0.589
2007 Funk CD, FitzGerald GA. COX-2 inhibitors and cardiovascular risk. Journal of Cardiovascular Pharmacology. 50: 470-9. PMID 18030055 DOI: 10.1097/Fjc.0B013E318157F72D  0.328
2007 Wada M, DeLong CJ, Hong YH, Rieke CJ, Song I, Sidhu RS, Yuan C, Warnock M, Schmaier AH, Yokoyama C, Smyth EM, Wilson SJ, FitzGerald GA, Garavito RM, Sui de X, et al. Enzymes and receptors of prostaglandin pathways with arachidonic acid-derived versus eicosapentaenoic acid-derived substrates and products. The Journal of Biological Chemistry. 282: 22254-66. PMID 17519235 DOI: 10.1074/Jbc.M703169200  0.613
2007 Curtis AM, Cheng Y, Kapoor S, Reilly D, Price TS, Fitzgerald GA. Circadian variation of blood pressure and the vascular response to asynchronous stress. Proceedings of the National Academy of Sciences of the United States of America. 104: 3450-5. PMID 17360665 DOI: 10.1073/Pnas.0611680104  0.621
2007 Price TS, Lucitt MB, Wu W, Austin DJ, Pizarro A, Yocum AK, Blair IA, FitzGerald GA, Grosser T. EBP, a program for protein identification using multiple tandem mass spectrometry datasets. Molecular & Cellular Proteomics : McP. 6: 527-36. PMID 17164401 DOI: 10.1074/Mcp.T600049-Mcp200  0.582
2007 Yu Y, Fan J, Hui Y, Rouzer CA, Marnett LJ, Klein-Szanto AJ, FitzGerald GA, Funk CD. Targeted cyclooxygenase gene (ptgs) exchange reveals discriminant isoform functionality. The Journal of Biological Chemistry. 282: 1498-506. PMID 17110378 DOI: 10.1074/Jbc.M609930200  0.332
2006 Egan K, FitzGerald GA. Eicosanoids and the vascular endothelium. Handbook of Experimental Pharmacology. 189-211. PMID 16999220 DOI: 10.1007/3-540-32967-6_6  0.337
2006 Wang M, Zukas AM, Hui Y, Ricciotti E, Puré E, FitzGerald GA. Deletion of microsomal prostaglandin E synthase-1 augments prostacyclin and retards atherogenesis. Proceedings of the National Academy of Sciences of the United States of America. 103: 14507-12. PMID 16973753 DOI: 10.1073/Pnas.0606586103  0.327
2006 Yu Y, Fan J, Chen XS, Wang D, Klein-Szanto AJ, Campbell RL, FitzGerald GA, Funk CD. Genetic model of selective COX2 inhibition reveals novel heterodimer signaling. Nature Medicine. 12: 699-704. PMID 16732282 DOI: 10.1038/Nm1412  0.33
2006 Cheng Y, Wang M, Yu Y, Lawson J, Funk CD, Fitzgerald GA. Cyclooxygenases, microsomal prostaglandin E synthase-1, and cardiovascular function. The Journal of Clinical Investigation. 116: 1391-9. PMID 16614756 DOI: 10.1172/Jci27540  0.346
2006 Lovgren AK, Jania LA, Hartney JM, Parsons KK, Audoly LP, Fitzgerald GA, Tilley SL, Koller BH. COX-2-derived prostacyclin protects against bleomycin-induced pulmonary fibrosis. American Journal of Physiology. Lung Cellular and Molecular Physiology. 291: L144-56. PMID 16473862 DOI: 10.1152/Ajplung.00492.2005  0.313
2006 Fries S, Grosser T, Price TS, Lawson JA, Kapoor S, DeMarco S, Pletcher MT, Wiltshire T, FitzGerald GA. Marked interindividual variability in the response to selective inhibitors of cyclooxygenase-2. Gastroenterology. 130: 55-64. PMID 16401468 DOI: 10.1053/J.Gastro.2005.10.002  0.619
2006 Grosser T, Fries S, FitzGerald GA. Biological basis for the cardiovascular consequences of COX-2 inhibition: therapeutic challenges and opportunities. The Journal of Clinical Investigation. 116: 4-15. PMID 16395396 DOI: 10.1172/Jci27291  0.326
2005 Rudic RD, McNamara P, Reilly D, Grosser T, Curtis AM, Price TS, Panda S, Hogenesch JB, FitzGerald GA. Bioinformatic analysis of circadian gene oscillation in mouse aorta. Circulation. 112: 2716-24. PMID 16230482 DOI: 10.1161/Circulationaha.105.568626  0.699
2005 Francois H, Athirakul K, Howell D, Dash R, Mao L, Kim HS, Rockman HA, Fitzgerald GA, Koller BH, Coffman TM. Prostacyclin protects against elevated blood pressure and cardiac fibrosis. Cell Metabolism. 2: 201-7. PMID 16154102 DOI: 10.1016/J.Cmet.2005.08.005  0.316
2005 Rudic RD, Brinster D, Cheng Y, Fries S, Song WL, Austin S, Coffman TM, FitzGerald GA. COX-2-derived prostacyclin modulates vascular remodeling. Circulation Research. 96: 1240-7. PMID 15905461 DOI: 10.1161/01.Res.0000170888.11669.28  0.331
2005 Wang D, Wong D, Wang M, Cheng Y, Fitzgerald GA. Cardiovascular hazard and non-steroidal anti-inflammatory drugs. Current Opinion in Pharmacology. 5: 204-10. PMID 15780832 DOI: 10.1016/J.Coph.2005.02.001  0.352
2005 Yu Y, Cheng Y, Fan J, Chen XS, Klein-Szanto A, Fitzgerald GA, Funk CD. Differential impact of prostaglandin H synthase 1 knockdown on platelets and parturition. The Journal of Clinical Investigation. 115: 986-95. PMID 15776109 DOI: 10.1172/Jci23683  0.332
2005 Pini B, Grosser T, Lawson JA, Price TS, Pack MA, FitzGerald GA. Prostaglandin E synthases in zebrafish. Arteriosclerosis, Thrombosis, and Vascular Biology. 25: 315-20. PMID 15576635 DOI: 10.1161/01.Atv.0000152355.97808.10  0.62
2005 Egan KM, Lawson JA, Fries S, Koller B, Rader DJ, Smyth EM, FitzGerald GA. Cyclooxygenase-2-Derived Prostacyclin Confers Atheroprotection on Female Mice Obstetrical & Gynecological Survey. 60: 309-310. DOI: 10.1097/01.Ogx.0000160574.33752.4F  0.64
2004 Egan KM, Lawson JA, Fries S, Koller B, Rader DJ, Smyth EM, Fitzgerald GA. COX-2-derived prostacyclin confers atheroprotection on female mice. Science (New York, N.Y.). 306: 1954-7. PMID 15550624 DOI: 10.1126/Science.1103333  0.618
2004 Hui Y, Cheng Y, Smalera I, Jian W, Goldhahn L, Fitzgerald GA, Funk CD. Directed vascular expression of human cysteinyl leukotriene 2 receptor modulates endothelial permeability and systemic blood pressure. Circulation. 110: 3360-6. PMID 15545522 DOI: 10.1161/01.Cir.0000147775.50954.Aa  0.316
2004 Rudic RD, McNamara P, Curtis AM, Boston RC, Panda S, Hogenesch JB, Fitzgerald GA. BMAL1 and CLOCK, two essential components of the circadian clock, are involved in glucose homeostasis. Plos Biology. 2: e377. PMID 15523558 DOI: 10.1371/Journal.Pbio.0020377  0.522
2004 Patrono C, Coller B, FitzGerald GA, Hirsh J, Roth G. Platelet-active drugs: the relationships among dose, effectiveness, and side effects: the Seventh ACCP Conference on Antithrombotic and Thrombolytic Therapy. Chest. 126: 234S-264S. PMID 15383474 DOI: 10.1378/Chest.126.3_Suppl.234S  0.304
2004 Sato TK, Panda S, Miraglia LJ, Reyes TM, Rudic RD, McNamara P, Naik KA, FitzGerald GA, Kay SA, Hogenesch JB. A functional genomics strategy reveals Rora as a component of the mammalian circadian clock. Neuron. 43: 527-37. PMID 15312651 DOI: 10.1016/J.Neuron.2004.07.018  0.544
2004 Curtis AM, Seo SB, Westgate EJ, Rudic RD, Smyth EM, Chakravarti D, FitzGerald GA, McNamara P. Histone acetyltransferase-dependent chromatin remodeling and the vascular clock. The Journal of Biological Chemistry. 279: 7091-7. PMID 14645221 DOI: 10.1074/Jbc.M311973200  0.603
2003 FitzGerald GA. COX-2 and beyond: Approaches to prostaglandin inhibition in human disease. Nature Reviews. Drug Discovery. 2: 879-90. PMID 14668809 DOI: 10.1038/Nrd1225  0.306
2003 Zhang Z, Vezza R, Plappert T, McNamara P, Lawson JA, Austin S, Praticò D, Sutton MS, FitzGerald GA. COX-2-dependent cardiac failure in Gh/tTG transgenic mice. Circulation Research. 92: 1153-61. PMID 12702643 DOI: 10.1161/01.Res.0000071749.22027.45  0.312
2002 Smyth EM, Austin SC, FitzGerald GA. Activation-dependent internalization of the human prostacyclin receptor. Advances in Experimental Medicine and Biology. 507: 295-301. PMID 12664600 DOI: 10.1007/978-1-4615-0193-0_45  0.594
2002 Smyth EM, FitzGerald GA. Human prostacyclin receptor. Vitamins and Hormones. 65: 149-65. PMID 12481546 DOI: 10.1016/S0083-6729(02)65063-0  0.615
2002 FitzGerald GA. The choreography of cyclooxygenases in the kidney. The Journal of Clinical Investigation. 110: 33-4. PMID 12093885 DOI: 10.1172/Jci16044  0.301
2002 Grosser T, Yusuff S, Cheskis E, Pack MA, FitzGerald GA. Developmental expression of functional cyclooxygenases in zebrafish. Proceedings of the National Academy of Sciences of the United States of America. 99: 8418-23. PMID 12011329 DOI: 10.1073/Pnas.112217799  0.31
2002 Cheng Y, Austin SC, Rocca B, Koller BH, Coffman TM, Grosser T, Lawson JA, FitzGerald GA. Role of prostacyclin in the cardiovascular response to thromboxane A2. Science (New York, N.Y.). 296: 539-41. PMID 11964481 DOI: 10.1126/Science.1068711  0.345
2002 FitzGerald GA. Cardiovascular pharmacology of nonselective nonsteroidal anti-inflammatory drugs and coxibs: clinical considerations. The American Journal of Cardiology. 89: 26D-32D. PMID 11909558 DOI: 10.1016/S0002-9149(02)02234-8  0.338
2002 Reilly M, FitzGerald GA. Gathering intelligence on antiplatelet drugs: the view from 30 000 feet. When combined with other information overviews lead to conviction. Bmj (Clinical Research Ed.). 324: 59-60. PMID 11786434 DOI: 10.1136/Bmj.324.7329.59  0.3
2001 Catella-Lawson F, Kapoor S, Moretti D, De Marco S, Vigilante GJ, Cucchiara AJ, Ramsey KE, Combe S, Rocca B, Theroux P, FitzGerald GA. Oral glycoprotein IIb/IIIa antagonism in patients with coronary artery disease. The American Journal of Cardiology. 88: 236-42. PMID 11472700 DOI: 10.1016/S0002-9149(01)01632-0  0.31
2001 McNamara P, Seo SB, Rudic RD, Sehgal A, Chakravarti D, FitzGerald GA. Regulation of CLOCK and MOP4 by nuclear hormone receptors in the vasculature: a humoral mechanism to reset a peripheral clock. Cell. 105: 877-89. PMID 11439184 DOI: 10.1016/S0092-8674(01)00401-9  0.302
2001 Praticò D, Tillmann C, Zhang ZB, Li H, FitzGerald GA. Acceleration of atherogenesis by COX-1-dependent prostanoid formation in low density lipoprotein receptor knockout mice. Proceedings of the National Academy of Sciences of the United States of America. 98: 3358-63. PMID 11248083 DOI: 10.1073/Pnas.061607398  0.369
2001 Fabre JE, Nguyen M, Athirakul K, Coggins K, McNeish JD, Austin S, Parise LK, FitzGerald GA, Coffman TM, Koller BH. Activation of the murine EP3 receptor for PGE2 inhibits cAMP production and promotes platelet aggregation. The Journal of Clinical Investigation. 107: 603-10. PMID 11238561 DOI: 10.1172/Jci10881  0.32
2001 Whitehead AS, FitzGerald GA. Twenty-first century phox: not yet ready for widespread screening. Circulation. 103: 7-9. PMID 11136676 DOI: 10.1161/01.Cir.103.1.7  0.305
2000 Praticò D, Cyrus T, Li H, FitzGerald GA. Endogenous biosynthesis of thromboxane and prostacyclin in 2 distinct murine models of atherosclerosis. Blood. 96: 3823-6. PMID 11090066 DOI: 10.1182/Blood.V96.12.3823.H8003823_3823_3826  0.322
2000 Praticó D, Cheng Y, FitzGerald GA. TP or not TP: primary mediators in a close runoff? Arteriosclerosis, Thrombosis, and Vascular Biology. 20: 1695-8. PMID 10894803 DOI: 10.1161/01.Atv.20.7.1695  0.323
2000 Smyth EM, Austin SC, Reilly MP, FitzGerald GA. Internalization and sequestration of the human prostacyclin receptor. The Journal of Biological Chemistry. 275: 32037-45. PMID 10889200 DOI: 10.1074/Jbc.M003873200  0.618
2000 Audoly LP, Rocca B, Fabre JE, Koller BH, Thomas D, Loeb AL, Coffman TM, FitzGerald GA. Cardiovascular responses to the isoprostanes iPF(2alpha)-III and iPE(2)-III are mediated via the thromboxane A(2) receptor in vivo. Circulation. 101: 2833-40. PMID 10859290 DOI: 10.1161/01.Cir.101.24.2833  0.303
1999 Austin S, FitzGerald GA. Not a mouse stirring: deletion of the EP2 and love's labor's lost. The Journal of Clinical Investigation. 103: 1481-2. PMID 10359555 DOI: 10.1172/Jci7289  0.326
1999 Habib A, FitzGerald GA, Maclouf J. Phosphorylation of the thromboxane receptor alpha, the predominant isoform expressed in human platelets. The Journal of Biological Chemistry. 274: 2645-51. PMID 9915793 DOI: 10.1074/Jbc.274.5.2645  0.308
1999 McAdam BF, Catella-Lawson F, Mardini IA, Kapoor S, Lawson JA, FitzGerald GA. Systemic biosynthesis of prostacyclin by cyclooxygenase (COX)-2: the human pharmacology of a selective inhibitor of COX-2. Proceedings of the National Academy of Sciences of the United States of America. 96: 272-7. PMID 9874808 DOI: 10.1073/Pnas.96.1.272  0.324
1998 Smyth EM, Li WH, FitzGerald GA. Phosphorylation of the prostacyclin receptor during homologous desensitization. A critical role for protein kinase c. The Journal of Biological Chemistry. 273: 23258-66. PMID 9722557 DOI: 10.1074/Jbc.273.36.23258  0.596
1998 Barry OP, Praticò D, Savani RC, FitzGerald GA. Modulation of monocyte-endothelial cell interactions by platelet microparticles. The Journal of Clinical Investigation. 102: 136-44. PMID 9649567 DOI: 10.1172/Jci2592  0.312
1998 Praticò D, Barry OP, Lawson JA, Adiyaman M, Hwang SW, Khanapure SP, Iuliano L, Rokach J, FitzGerald GA. IPF2alpha-I: an index of lipid peroxidation in humans. Proceedings of the National Academy of Sciences of the United States of America. 95: 3449-54. PMID 9520386 DOI: 10.1073/Pnas.95.7.3449  0.307
1998 Reilly MP, Lawson JA, FitzGerald GA. Eicosanoids and isoeicosanoids: indices of cellular function and oxidant stress. The Journal of Nutrition. 128: 434S-438S. PMID 9478043 DOI: 10.1093/Jn/128.2.434S  0.317
1997 Patrono C, FitzGerald GA. Isoprostanes: potential markers of oxidant stress in atherothrombotic disease. Arteriosclerosis, Thrombosis, and Vascular Biology. 17: 2309-15. PMID 9409197 DOI: 10.1161/01.Atv.17.11.2309  0.313
1997 FitzGerald GA, Tigges J, Barry P, Lawson JA. Markers of platelet activation and oxidant stress in atherothrombotic disease. Thrombosis and Haemostasis. 78: 280-4. PMID 9198167 DOI: 10.1055/S-0038-1657540  0.306
1997 Catella-Lawson F, FitzGerald GA. Confusion in reperfusion. Problems in the clinical development of antithrombotic drugs. Circulation. 95: 793-5. PMID 9054731 DOI: 10.1161/01.Cir.95.4.793  0.325
1997 Rocca B, FitzGerald GA. Simply read: erythrocytes modulate platelet function. Should we rethink the way we give aspirin? Circulation. 95: 11-3. PMID 8994408 DOI: 10.1161/01.Cir.95.1.11  0.31
1996 Smyth EM, Nestor PV, FitzGerald GA. Agonist-dependent phosphorylation of an epitope-tagged human prostacyclin receptor. The Journal of Biological Chemistry. 271: 33698-704. PMID 8969241 DOI: 10.1074/Jbc.271.52.33698  0.606
1996 Praticò D, Smyth EM, Violi F, FitzGerald GA. Local amplification of platelet function by 8-Epi prostaglandin F2alpha is not mediated by thromboxane receptor isoforms. The Journal of Biological Chemistry. 271: 14916-24. PMID 8663015 DOI: 10.1074/Jbc.271.25.14916  0.627
1994 FitzGerald GA, Shipp E. Antiplatelet and anticoagulant drugs in coronary vascular disease. Annals of Epidemiology. 2: 529-42. PMID 1342304 DOI: 10.1016/1047-2797(92)90103-W  0.325
1991 Clarke RJ, Mayo G, FitzGerald GA, Fitzgerald DJ. Combined administration of aspirin and a specific thrombin inhibitor in man. Circulation. 83: 1510-8. PMID 2022012 DOI: 10.1161/01.Cir.83.5.1510  0.302
1991 FitzGerald GA. Mechanisms of platelet activation: Thromboxane A2 as an amplifying signal for other agonists The American Journal of Cardiology. 68. PMID 1892057 DOI: 10.1016/0002-9149(91)90379-Y  0.329
1991 Funk CD, Funk LB, Kennedy ME, Pong AS, Fitzgerald GA. Human platelet/erythroleukemia cell prostaglandin G/H synthase: cDNA cloning, expression, and gene chromosomal assignment The Faseb Journal. 5: 2304-2312. DOI: 10.1096/Fasebj.5.9.1907252  0.315
1990 Sebaldt RJ, Sheller JR, Oates JA, Roberts LJ, FitzGerald GA. Inhibition of eicosanoid biosynthesis by glucocorticoids in humans. Proceedings of the National Academy of Sciences of the United States of America. 87: 6974-8. PMID 2169616 DOI: 10.1073/Pnas.87.18.6974  0.316
1989 Fitzgerald GA, Braden G, Fitzgerald DJ, Knapp HR. Fish oils in cardiovascular disease Journal of Internal Medicine. 225: 25-29. PMID 2650696 DOI: 10.1111/J.1365-2796.1989.Tb01432.X  0.313
1989 Nowak J, FitzGerald GA. Redirection of prostaglandin endoperoxide metabolism at the platelet-vascular interface in man. The Journal of Clinical Investigation. 83: 380-5. PMID 2643628 DOI: 10.1172/Jci113895  0.322
1989 Murray R, FitzGerald GA. Regulation of thromboxane receptor activation in human platelets. Proceedings of the National Academy of Sciences of the United States of America. 86: 124-8. PMID 2521385 DOI: 10.1073/Pnas.86.1.124  0.303
1989 Lupinetti MD, Sheller JR, Catella F, Fitzgerald GA. Thromboxane biosynthesis in allergen-induced bronchospasm. Evidence for platelet activation. The American Review of Respiratory Disease. 140: 932-5. PMID 2508524 DOI: 10.1164/Ajrccm/140.4.932  0.303
1989 Fitzgerald DJ, Wright F, FitzGerald GA. Increased thromboxane biosynthesis during coronary thrombolysis. Evidence that platelet activation and thromboxane A2 modulate the response to tissue-type plasminogen activator in vivo. Circulation Research. 65: 83-94. PMID 2500270 DOI: 10.1161/01.Res.65.1.83  0.302
1988 Catella F, FitzGerald GA. Paired analysis of urinary thromboxane B2 metabolites in humans. Thrombosis Research. 47: 647-56. PMID 3686481 DOI: 10.1016/0049-3848(87)90103-4  0.313
1988 Fitzgerald DJ, Fragetta J, FitzGerald GA. Prostaglandin endoperoxides modulate the response to thromboxane synthase inhibition during coronary thrombosis. The Journal of Clinical Investigation. 82: 1708-13. PMID 3183064 DOI: 10.1172/Jci113784  0.339
1987 Fitzgerald GA, Catella F, Oates JA. Eicosanoid biosynthesis in human cardiovascular disease. Human Pathology. 18: 248-52. PMID 3546074 DOI: 10.1016/S0046-8177(87)80007-2  0.327
1986 FitzGerald GA, Reilly IA, Pedersen AK. The biochemical pharmacology of thromboxane synthase inhibition in man. Circulation. 72: 1194-201. PMID 3905048 DOI: 10.1161/01.Cir.72.6.1194  0.323
1986 Fitzgerald DJ, Roy L, Catella F, FitzGerald GA. Platelet activation in unstable coronary disease. The New England Journal of Medicine. 315: 983-9. PMID 3531859 DOI: 10.1056/Nejm198610163151602  0.303
1986 Fitzgerald DJ, Doran J, Jackson E, FitzGerald GA. Coronary vascular occlusion mediated via thromboxane A2-prostaglandin endoperoxide receptor activation in vivo. The Journal of Clinical Investigation. 77: 496-502. PMID 3003161 DOI: 10.1172/Jci112329  0.31
1986 Reilly IA, Doran JB, Smith B, FitzGerald GA. Increased thromboxane biosynthesis in a human preparation of platelet activation: biochemical and functional consequences of selective inhibition of thromboxane synthase. Circulation. 73: 1300-9. PMID 2938849 DOI: 10.1161/01.Cir.73.6.1300  0.335
1985 Pedersen AK, FitzGerald GA. Cyclooxygenase inhibition, platelet function, and metabolite formation during chronic sulfinpyrazone dosing. Clinical Pharmacology and Therapeutics. 37: 36-42. PMID 3917387 DOI: 10.1038/Clpt.1985.8  0.309
1984 FitzGerald GA, Oates JA. Selective and nonselective inhibition of thromboxane formation. Clinical Pharmacology and Therapeutics. 35: 633-40. PMID 6370554 DOI: 10.1038/Clpt.1984.87  0.327
1984 FitzGerald GA, Smith B, Pedersen AK, Brash AR. Increased prostacyclin biosynthesis in patients with severe atherosclerosis and platelet activation. The New England Journal of Medicine. 310: 1065-8. PMID 6231483 DOI: 10.1056/Nejm198404263101701  0.324
1983 FitzGerald GA, Brash AR, Oates JA, Pedersen AK. Endogenous prostacyclin biosynthesis and platelet function during selective inhibition of thromboxane synthase in man. The Journal of Clinical Investigation. 72: 1336-43. PMID 6355181 DOI: 10.1172/Jci111089  0.308
Low-probability matches (unlikely to be authored by this person)
1999 Vezza R, Habib A, FitzGerald GA. Differential signaling by the thromboxane receptor isoforms via the novel GTP-binding protein, Gh. The Journal of Biological Chemistry. 274: 12774-9. PMID 10212262 DOI: 10.1074/Jbc.274.18.12774  0.3
2006 North TE, Goessling W, Kopani KR, Lengerke C, Walkley CR, Lord AM, Jang I, Grosser T, FitzGerald GA, Daley GQ, Orkin SH, Zon LI. Prostaglandin E2 Is a Potent Regulator of Vertebrate Hematopoietic Stem Cell Homeostasis. Blood. 108: 680-680. DOI: 10.1182/Blood.V108.11.680.680  0.3
2004 Kothapalli D, Fuki I, Ali K, Stewart SA, Zhao L, Yahil R, Kwiatkowski D, Hawthorne EA, FitzGerald GA, Phillips MC, Lund-Katz S, Puré E, Rader DJ, Assoian RK. Antimitogenic effects of HDL and APOE mediated by Cox-2-dependent IP activation. The Journal of Clinical Investigation. 113: 609-18. PMID 14966570 DOI: 10.1172/Jci19097  0.299
1984 Fitzgerald DJ, Roy L, Robertson RM, FitzGerald GA. The effects of organic nitrates on prostacyclin biosynthesis and platelet function in humans. Circulation. 70: 297-302. PMID 6428771 DOI: 10.1161/01.Cir.70.2.297  0.299
1995 Catella-Lawson F, FitzGerald GA. Long-term aspirin in the prevention of cardiovascular disorders. Recent developments and variations on a theme. Drug Safety. 13: 69-75. PMID 7576265 DOI: 10.2165/00002018-199513020-00001  0.299
1986 Reilly IA, Roy L, Fitzgerald GA. Biosynthesis of thromboxane in patients with systemic sclerosis and Raynaud's phenomenon. British Medical Journal (Clinical Research Ed.). 292: 1037-9. PMID 3083991 DOI: 10.1136/Bmj.292.6527.1037  0.299
2002 McNamara P, Lawson JA, Rokach J, FitzGerald GA. Isoprostane activation of the nuclear hormone receptor PPAR. Advances in Experimental Medicine and Biology. 507: 351-5. PMID 12664609 DOI: 10.1007/978-1-4615-0193-0_54  0.299
2015 FitzGerald GA. BIOMEDICINE. Bringing PGE₂ in from the cold. Science (New York, N.Y.). 348: 1208-9. PMID 26068834 DOI: 10.1126/Science.Aac5515  0.299
1989 Fitzgerald DJ, Fitzgerald GA. Role of thrombin and thromboxane A2 in reocclusion following coronary thrombolysis with tissue-type plasminogen activator. Proceedings of the National Academy of Sciences of the United States of America. 86: 7585-9. PMID 2508092 DOI: 10.1073/Pnas.86.19.7585  0.298
2001 Catella-Lawson F, Reilly MP, Kapoor SC, Cucchiara AJ, DeMarco S, Tournier B, Vyas SN, FitzGerald GA. Cyclooxygenase inhibitors and the antiplatelet effects of aspirin. The New England Journal of Medicine. 345: 1809-17. PMID 11752357 DOI: 10.1056/Nejmoa003199  0.298
1986 Catella F, Nowak J, Fitzgerald GA. Measurement of renal and non-renal eicosanoid synthesis. The American Journal of Medicine. 81: 23-9. PMID 3092663 DOI: 10.1016/0002-9343(86)90905-8  0.298
2015 Liang X, Bittinger K, Li X, Abernethy DR, Bushman FD, FitzGerald GA. Bidirectional interactions between indomethacin and the murine intestinal microbiota. Elife. 4: e08973. PMID 26701907 DOI: 10.7554/Elife.08973  0.297
2000 McAdam BF, Mardini IA, Habib A, Burke A, Lawson JA, Kapoor S, FitzGerald GA. Effect of regulated expression of human cyclooxygenase isoforms on eicosanoid and isoeicosanoid production in inflammation. The Journal of Clinical Investigation. 105: 1473-82. PMID 10811855 DOI: 10.1172/Jci9523  0.297
1996 FitzGerald GA. The human pharmacology of thrombin inhibition. Coronary Artery Disease. 7: 911-8. PMID 9116934 DOI: 10.1097/00019501-199612000-00006  0.297
1983 FitzGerald GA, Oates JA, Hawiger J, Maas RL, Roberts LJ, Lawson JA, Brash AR. Endogenous biosynthesis of prostacyclin and thromboxane and platelet function during chronic administration of aspirin in man. The Journal of Clinical Investigation. 71: 676-88. PMID 6338043 DOI: 10.1172/Jci110814  0.297
1985 Goldberg MR, Robertson D, FitzGerald GA. Prostacyclin biosynthesis and platelet function in autonomic dysfunction. Neurology. 35: 120-3. PMID 3838109 DOI: 10.1212/Wnl.35.1.120  0.296
2003 Griendling KK, FitzGerald GA. Oxidative stress and cardiovascular injury: Part II: animal and human studies. Circulation. 108: 2034-40. PMID 14581381 DOI: 10.1161/01.Cir.0000093661.90582.C4  0.295
2017 Prentice KJ, Wendell SG, Liu Y, Eversley JA, Salvatore SR, Mohan H, Brandt SL, Adams AC, Serena Wang X, Wei D, FitzGerald GA, Durham TB, Hammond CD, Sloop KW, Skarke C, et al. CMPF, a Metabolite Formed Upon Prescription Omega-3-Acid Ethyl Ester Supplementation, Prevents and Reverses Steatosis. Ebiomedicine. PMID 29290411 DOI: 10.1016/J.Ebiom.2017.12.019  0.295
2003 Griendling KK, FitzGerald GA. Oxidative stress and cardiovascular injury: Part I: basic mechanisms and in vivo monitoring of ROS. Circulation. 108: 1912-6. PMID 14568884 DOI: 10.1161/01.Cir.0000093660.86242.Bb  0.295
1990 Funk CD, Furci L, FitzGerald GA. Molecular cloning, primary structure, and expression of the human platelet/erythroleukemia cell 12-lipoxygenase. Proceedings of the National Academy of Sciences of the United States of America. 87: 5638-42. PMID 2377602 DOI: 10.1073/Pnas.87.15.5638  0.295
2014 Yan S, Zhang Q, Zhong X, Tang J, Wang Y, Yu J, Zhou Y, Zhang J, Guo F, Liu Y, FitzGerald GA, Yu Y. I prostanoid receptor-mediated inflammatory pathway promotes hepatic gluconeogenesis through activation of PKA and inhibition of AKT. Diabetes. 63: 2911-23. PMID 24722246 DOI: 10.2337/Db13-1893  0.294
2013 Musiek ES, Fitzgerald GA. Molecular clocks in pharmacology. Handbook of Experimental Pharmacology. 243-60. PMID 23604482 DOI: 10.1007/978-3-642-25950-0_10  0.294
2016 Mazaleuskaya LL, Lawson JA, Li X, Grant G, Mesaros C, Grosser T, Blair IA, Ricciotti E, FitzGerald GA. A broad-spectrum lipidomics screen of antiinflammatory drug combinations in human blood. Jci Insight. 1. PMID 27547824 DOI: 10.1172/Jci.Insight.87031  0.294
1986 Catella F, Healy D, Lawson JA, FitzGerald GA. 11-Dehydrothromboxane B2: A quantitative index of thromboxane A2 formation in the human circulation Proceedings of the National Academy of Sciences of the United States of America. 83: 5861-5865. PMID 3461463 DOI: 10.1073/Pnas.83.16.5861  0.294
1999 Barry OP, FitzGerald GA. Mechanisms of cellular activation by platelet microparticles. Thrombosis and Haemostasis. 82: 794-800. PMID 10605784 DOI: 10.1055/S-0037-1615913  0.294
2007 Chou WL, Chuang LM, Chou CC, Wang AH, Lawson JA, FitzGerald GA, Chang ZF. Identification of a novel prostaglandin reductase reveals the involvement of prostaglandin E2 catabolism in regulation of peroxisome proliferator-activated receptor gamma activation. The Journal of Biological Chemistry. 282: 18162-72. PMID 17449869 DOI: 10.1074/Jbc.M702289200  0.293
2019 Theken KN, Hersh EV, Lahens NF, Lee HM, Li X, Granquist EJ, Giannakopoulos H, Levin LM, Secreto SA, Grant GR, Detre JA, FitzGerald GA, Grosser T, Farrar JT. Variability in the Analgesic Response to Ibuprofen is Associated with Cyclooxygenase Activation in Inflammatory Pain. Clinical Pharmacology and Therapeutics. PMID 30929268 DOI: 10.1002/Cpt.1446  0.293
1990 Braden GA, Knapp HR, Fitzgerald DJ, FitzGerald GA. Dietary fish oil accelerates the response to coronary thrombolysis with tissue-type plasminogen activator. Evidence for a modest platelet inhibitory effect in vivo Circulation. 82: 178-187. PMID 2114234 DOI: 10.1161/01.Cir.82.1.178  0.292
2010 Grosser T, Yu Y, Fitzgerald GA. Emotion recollected in tranquility: lessons learned from the COX-2 saga. Annual Review of Medicine. 61: 17-33. PMID 20059330 DOI: 10.1146/Annurev-Med-011209-153129  0.292
1995 Pratico D, Lawson JA, FitzGerald GA. Cyclooxygenase-dependent formation of the isoprostane, 8-epi prostaglandin F2 alpha. The Journal of Biological Chemistry. 270: 9800-8. PMID 7730359 DOI: 10.1074/Jbc.270.17.9800  0.292
1997 Rokach J, Khanapure SP, Hwang SW, Adiyaman M, Lawson JA, FitzGerald GA. The isoprostanes: a perspective. Prostaglandins. 54: 823-51. PMID 9533180 DOI: 10.1016/S0090-6980(97)00183-4  0.292
1988 Reilly IA, FitzGerald GA. Aspirin in cardiovascular disease. Drugs. 35: 154-76. PMID 3281822 DOI: 10.2165/00003495-198835020-00005  0.291
2001 Tangirala RK, Praticó D, FitzGerald GA, Chun S, Tsukamoto K, Maugeais C, Usher DC, Puré E, Rader DJ. Reduction of isoprostanes and regression of advanced atherosclerosis by apolipoprotein E. The Journal of Biological Chemistry. 276: 261-6. PMID 11024044 DOI: 10.1074/Jbc.M003324200  0.29
2013 Song WL, FitzGerald GA. Niacin, an old drug with a new twist. Journal of Lipid Research. 54: 2586-94. PMID 23948546 DOI: 10.1194/Jlr.R040592  0.29
1992 Kerins DM, Roy L, Kunitada S, Adedoyin A, FitzGerald GA, Fitzgerald DJ. Pharmacokinetics of tissue-type plasminogen activator during acute myocardial infarction in men. Effect of a prostacyclin analogue. Circulation. 85: 526-32. PMID 1370924 DOI: 10.1161/01.Cir.85.2.526  0.289
1990 Sladek K, Dworski R, Fitzgerald GA, Buitkus KL, Block FJ, Marney SR, Sheller JR. Allergen-stimulated release of thromboxane A2 and leukotriene E4 in humans. Effect of indomethacin. The American Review of Respiratory Disease. 141: 1441-5. PMID 2161626 DOI: 10.1164/Ajrccm/141.6.1441  0.289
1984 Pedersen AK, FitzGerald GA. Dose-related kinetics of aspirin. Presystemic acetylation of platelet cyclooxygenase. The New England Journal of Medicine. 311: 1206-11. PMID 6436696 DOI: 10.1056/Nejm198411083111902  0.289
2007 Reilly DF, Westgate EJ, FitzGerald GA. Peripheral circadian clocks in the vasculature. Arteriosclerosis, Thrombosis, and Vascular Biology. 27: 1694-705. PMID 17541024 DOI: 10.1161/Atvbaha.107.144923  0.289
2008 Song WL, Wang M, Ricciotti E, Fries S, Yu Y, Grosser T, Reilly M, Lawson JA, FitzGerald GA. Tetranor PGDM, an abundant urinary metabolite reflects biosynthesis of prostaglandin D2 in mice and humans. The Journal of Biological Chemistry. 283: 1179-88. PMID 17993463 DOI: 10.1074/Jbc.M706839200  0.289
1989 Dworski R, Sheller JR, Wickersham NE, Oates JA, Brigham KL, Roberts LJ, Fitzgerald GA. Allergen-stimulated release of mediators into sheep bronchoalveolar lavage fluid. Effect of cyclooxygenase inhibition. The American Review of Respiratory Disease. 139: 46-51. PMID 2492175 DOI: 10.1164/Ajrccm/139.1.46  0.288
2013 Chen L, Yang G, Xu X, Grant G, Lawson JA, Bohlooly-Y M, FitzGerald GA. Cell selective cardiovascular biology of microsomal prostaglandin E synthase-1. Circulation. 127: 233-43. PMID 23204105 DOI: 10.1161/Circulationaha.112.119479  0.288
2013 Fitzgerald DJ, Fitzgerald GA. Historical lessons in translational medicine: cyclooxygenase inhibition and P2Y12 antagonism. Circulation Research. 112: 174-94. PMID 23287454 DOI: 10.1161/Circresaha.111.300271  0.288
2007 García Rodríguez LA, Egan K, FitzGerald GA. Traditional nonsteroidal anti-inflammatory drugs and postmenopausal hormone therapy: a drug-drug interaction? Plos Medicine. 4: e157. PMID 17518513 DOI: 10.1371/Journal.Pmed.0040157  0.288
2007 FitzGerald GA. COX-2 in play at the AHA and the FDA. Trends in Pharmacological Sciences. 28: 303-7. PMID 17573128 DOI: 10.1016/J.Tips.2007.05.007  0.288
2016 Yang G, Chen L, Grant GR, Paschos G, Song WL, Musiek ES, Lee V, McLoughlin SC, Grosser T, Cotsarelis G, FitzGerald GA. Timing of expression of the core clock gene Bmal1 influences its effects on aging and survival. Science Translational Medicine. 8: 324ra16. PMID 26843191 DOI: 10.1126/Scitranslmed.Aad3305  0.288
2012 Grad E, Pachino RM, FitzGerald GA, Danenberg HD. Role of thromboxane receptor in C-reactive protein-induced thrombosis. Arteriosclerosis, Thrombosis, and Vascular Biology. 32: 2468-74. PMID 22879580 DOI: 10.1161/Atvbaha.112.256073  0.287
2000 Meagher EA, FitzGerald GA. Indices of lipid peroxidation in vivo: strengths and limitations. Free Radical Biology & Medicine. 28: 1745-50. PMID 10946216 DOI: 10.1016/S0891-5849(00)00232-X  0.287
2000 Rocca B, Loeb AL, Strauss JF, Vezza R, Habib A, Li H, FitzGerald GA. Directed vascular expression of the thromboxane A2 receptor results in intrauterine growth retardation. Nature Medicine. 6: 219-21. PMID 10655114 DOI: 10.1038/72334  0.287
2005 Kadiiska MB, Gladen BC, Baird DD, Graham LB, Parker CE, Ames BN, Basu S, Fitzgerald GA, Lawson JA, Marnett LJ, Morrow JD, Murray DM, Plastaras J, Roberts LJ, Rokach J, et al. Biomarkers of oxidative stress study III. Effects of the nonsteroidal anti-inflammatory agents indomethacin and meclofenamic acid on measurements of oxidative products of lipids in CCl4 poisoning. Free Radical Biology & Medicine. 38: 711-8. PMID 15721981 DOI: 10.1016/J.Freeradbiomed.2004.10.024  0.287
1986 Knapp HR, Reilly IAG, Alessandrini P, Fitzgerald GA. In vivo indexes of platelet and vascular function during fish-oil adminstration in patients with atherosclerosis New England Journal of Medicine. 314: 937-942. PMID 3007982 DOI: 10.1056/Nejm198604103141501  0.287
1997 Reilly M, Barry P, Lawson J, FitzGerald G. Urinary 8-EPI PGF2α: an index of oxidant stress in vivo Fibrinolysis and Proteolysis. 11: 81-84. DOI: 10.1016/S0268-9499(97)80029-X  0.286
2018 Li X, Ballantyne LL, Crawford MC, FitzGerald GA, Funk CD. Isoform-Specific Compensation of Cyclooxygenase (Ptgs) Genes during Implantation and Late-Stage Pregnancy. Scientific Reports. 8: 12097. PMID 30108257 DOI: 10.1038/S41598-018-30636-X  0.286
2012 Garza LA, Liu Y, Yang Z, Alagesan B, Lawson JA, Norberg SM, Loy DE, Zhao T, Blatt HB, Stanton DC, Carrasco L, Ahluwalia G, Fischer SM, FitzGerald GA, Cotsarelis G. Prostaglandin D2 inhibits hair growth and is elevated in bald scalp of men with androgenetic alopecia. Science Translational Medicine. 4: 126ra34. PMID 22440736 DOI: 10.1126/Scitranslmed.3003122  0.286
2013 McLoughlin SC, FitzGerald GA. Between a rock and a hard place: how to align our circadian rhythms? Circulation. 127: 19-20. PMID 23172837 DOI: 10.1161/Circulationaha.112.150417  0.286
2017 Grosser T, Ricciotti E, FitzGerald GA. The Cardiovascular Pharmacology of Nonsteroidal Anti-Inflammatory Drugs. Trends in Pharmacological Sciences. PMID 28651847 DOI: 10.1016/J.Tips.2017.05.008  0.286
2001 Vezza R, Rokach J, FitzGerald GA. Prostaglandin F(2alpha) receptor-dependent regulation of prostaglandin transport. Molecular Pharmacology. 59: 1506-13. PMID 11353812 DOI: 10.1124/Mol.59.6.1506  0.285
2014 Zhou W, Goleniewska K, Zhang J, Dulek DE, Toki S, Lotz MT, Newcomb DC, Boswell MG, Polosukhin VV, Milne GL, Wu P, Moore ML, FitzGerald GA, Peebles RS. Cyclooxygenase inhibition abrogates aeroallergen-induced immune tolerance by suppressing prostaglandin I2 receptor signaling. The Journal of Allergy and Clinical Immunology. 134: 698-705.e5. PMID 25042746 DOI: 10.1016/J.Jaci.2014.06.004  0.285
2016 FitzGerald GA. Human Platelet Lipidomics: Variance, Visualization, Flux, and Fuel. Cell Metabolism. 23: 757-9. PMID 27166936 DOI: 10.1016/J.Cmet.2016.04.025  0.284
1999 Barry OP, Kazanietz MG, Praticò D, FitzGerald GA. Arachidonic acid in platelet microparticles up-regulates cyclooxygenase-2-dependent prostaglandin formation via a protein kinase C/mitogen-activated protein kinase-dependent pathway. The Journal of Biological Chemistry. 274: 7545-56. PMID 10066822 DOI: 10.1074/Jbc.274.11.7545  0.284
1999 Rocca B, Spain LM, Puré E, Langenbach R, Patrono C, FitzGerald GA. Distinct roles of prostaglandin H synthases 1 and 2 in T-cell development. The Journal of Clinical Investigation. 103: 1469-77. PMID 10330429 DOI: 10.1172/Jci6400  0.284
2004 Fitzgerald GA. Coxibs and cardiovascular disease. The New England Journal of Medicine. 351: 1709-11. PMID 15470192 DOI: 10.1056/Nejmp048288  0.284
1996 Delanty N, Reilly M, Pratico D, FitzGerald DJ, Lawson JA, FitzGerald GA. 8-Epi PGF2 alpha: specific analysis of an isoeicosanoid as an index of oxidant stress in vivo. British Journal of Clinical Pharmacology. 42: 15-9. PMID 8807139 DOI: 10.1046/J.1365-2125.1996.03804.X  0.284
1997 Habib A, Vezza R, Créminon C, Maclouf J, FitzGerald GA. Rapid, agonist-dependent phosphorylation in vivo of human thromboxane receptor isoforms. Minimal involvement of protein kinase C. The Journal of Biological Chemistry. 272: 7191-200. PMID 9054415 DOI: 10.1074/Jbc.272.11.7191  0.283
1988 Kühl PG, Bolds JM, Loyd JE, Snapper JR, FitzGerald GA. Thromboxane receptor-mediated bronchial and hemodynamic responses in ovine endotoxemia. The American Journal of Physiology. 254: R310-9. PMID 2964208 DOI: 10.1152/Ajpregu.1988.254.2.R310  0.283
1986 Lawson JA, Patrono C, Ciabattoni G, FitzGerald GA. Long-lived enzymatic metabolites of thromboxane B2 in the human circulation Analytical Biochemistry. 155: 198-205. PMID 3087234 DOI: 10.1016/0003-2697(86)90247-2  0.283
2008 Parastatidis I, Thomson L, Burke A, Chernysh I, Nagaswami C, Visser J, Stamer S, Liebler DC, Koliakos G, Heijnen HF, Fitzgerald GA, Weisel JW, Ischiropoulos H. Fibrinogen beta-chain tyrosine nitration is a prothrombotic risk factor. The Journal of Biological Chemistry. 283: 33846-53. PMID 18818200 DOI: 10.1074/Jbc.M805522200  0.283
2004 Fitzgerald GA. Prostaglandins: modulators of inflammation and cardiovascular risk. Journal of Clinical Rheumatology : Practical Reports On Rheumatic & Musculoskeletal Diseases. 10: S12-7. PMID 17043495 DOI: 10.1097/01.Rhu.0000130685.73681.8B  0.283
1992 Remuzzi G, FitzGerald GA, Patrono C. Thromboxane synthesis and action within the kidney. Kidney International. 41: 1483-93. PMID 1501404 DOI: 10.1038/Ki.1992.217  0.283
1990 Kerins DM, Roy L, FitzGerald GA, Fitzgerald DJ. Platelet and vascular function during coronary thrombolysis with tissue-type plasminogen activator. Circulation. 80: 1718-25. PMID 2513144 DOI: 10.1161/01.Cir.80.6.1718  0.283
2008 Reilly DF, Curtis AM, Cheng Y, Westgate EJ, Rudic RD, Paschos G, Morris J, Ouyang M, Thomas SA, FitzGerald GA. Peripheral circadian clock rhythmicity is retained in the absence of adrenergic signaling. Arteriosclerosis, Thrombosis, and Vascular Biology. 28: 121-6. PMID 17975121 DOI: 10.1161/Atvbaha.107.152538  0.282
1988 Fitzgerald DJ, Catella F, Roy L, FitzGerald GA. Marked platelet activation in vivo after intravenous streptokinase in patients with acute myocardial infarction. Circulation. 77: 142-50. PMID 3275505 DOI: 10.1161/01.Cir.77.1.142  0.282
1986 Reilly IA, FitzGerald GA. Eicosenoid biosynthesis and platelet function with advancing age. Thrombosis Research. 41: 545-54. PMID 3754355 DOI: 10.1016/0049-3848(86)91700-7  0.282
2008 Song WL, Lawson JA, Reilly D, Rokach J, Chang CT, Giasson B, FitzGerald GA. Neurofurans, novel indices of oxidant stress derived from docosahexaenoic acid. The Journal of Biological Chemistry. 283: 6-16. PMID 17921521 DOI: 10.1074/Jbc.M706124200  0.282
1981 Fitzgerald GA, Maas RL, Stein R, Oates JA, Roberts LJ. Intravenous prostacyclin in thrombotic thrombocytopenic purpura. Annals of Internal Medicine. 95: 319-22. PMID 7023309 DOI: 10.7326/0003-4819-95-3-319  0.282
2015 McLoughlin SC, Haines P, FitzGerald GA. Clocks and cardiovascular function. Methods in Enzymology. 552: 211-28. PMID 25707279 DOI: 10.1016/Bs.Mie.2014.11.029  0.282
1998 Praticò D, Tangirala RK, Rader DJ, Rokach J, FitzGerald GA. Vitamin E suppresses isoprostane generation in vivo and reduces atherosclerosis in ApoE-deficient mice. Nature Medicine. 4: 1189-92. PMID 9771755 DOI: 10.1038/2685  0.282
2018 Li X, Mazaleuskaya LL, Ballantyne LL, Meng H, FitzGerald GA, Funk CD. Differential compensation of two cyclooxygenases in renal homeostasis is independent of prostaglandin-synthetic capacity under basal conditions. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. fj201800252R. PMID 29676940 DOI: 10.1096/Fj.201800252R  0.282
2011 Winnik S, Lohmann C, Richter EK, Schäfer N, Song WL, Leiber F, Mocharla P, Hofmann J, Klingenberg R, Borén J, Becher B, Fitzgerald GA, Lüscher TF, Matter CM, Beer JH. Dietary α-linolenic acid diminishes experimental atherogenesis and restricts T cell-driven inflammation. European Heart Journal. 32: 2573-84. PMID 21285075 DOI: 10.1093/Eurheartj/Ehq501  0.282
1988 Knapp HR, Healy C, Lawson J, FitzGerald GA. Effects of low-dose aspirin on endogenous eicosanoid formation in normal and atherosclerotic men. Thrombosis Research. 50: 377-86. PMID 3293263 DOI: 10.1016/0049-3848(88)90267-8  0.281
2013 Bhala N, Emberson J, Merhi A, Abramson S, Arber N, Baron JA, Bombardier C, Cannon C, Farkouh ME, FitzGerald GA, Goss P, Halls H, Hawk E, Hawkey C, et al. Vascular and upper gastrointestinal effects of non-steroidal anti-inflammatory drugs: meta-analyses of individual participant data from randomised trials. Lancet. 382: 769-79. PMID 23726390 DOI: 10.1016/S0140-6736(13)60900-9  0.281
2001 Praticò D, Lawson JA, Rokach J, FitzGerald GA. The isoprostanes in biology and medicine. Trends in Endocrinology and Metabolism: Tem. 12: 243-7. PMID 11445440 DOI: 10.1016/S1043-2760(01)00411-8  0.281
2013 Nelson AM, Loy DE, Lawson JA, Katseff AS, Fitzgerald GA, Garza LA. Prostaglandin D2 inhibits wound-induced hair follicle neogenesis through the receptor, Gpr44. The Journal of Investigative Dermatology. 133: 881-9. PMID 23190891 DOI: 10.1038/Jid.2012.398  0.28
1988 Alessandrini P, McRae J, Feman S, FitzGerald GA. Thromboxane biosynthesis and platelet function in Type I diabetes mellitus New England Journal of Medicine. 319: 208-212. PMID 3292913 DOI: 10.1056/Nejm198807283190404  0.28
2001 Bennett JS, Catella-Lawson F, Rut AR, Vilaire G, Qi W, Kapoor SC, Murphy S, FitzGerald GA. Effect of the Pl(A2) alloantigen on the function of beta(3)-integrins in platelets. Blood. 97: 3093-9. PMID 11342435 DOI: 10.1182/Blood.V97.10.3093  0.278
1990 Catella F, Lawson JA, FitzGerald DJ, Fitzgerald GA. Endogenous biosynthesis of arachidonic acid epoxides in humans: Increased formation in pregnancy-induced hypertension Proceedings of the National Academy of Sciences of the United States of America. 87: 5893-5897. PMID 2198572 DOI: 10.1073/Pnas.87.15.5893  0.278
2018 Hao H, Hu S, Wan Q, Xu C, Chen H, Zhu L, Xu Z, Meng J, Breyer RM, Li N, Liu DP, FitzGerald GA, Wang M. Protective Role of mPGES-1 (Microsomal Prostaglandin E Synthase-1)-Derived PGE(Prostaglandin E2) and the Endothelial EP4 (Prostaglandin E Receptor) in Vascular Responses to Injury. Arteriosclerosis, Thrombosis, and Vascular Biology. PMID 29599139 DOI: 10.1161/Atvbaha.118.310713  0.278
2013 Toki S, Goleniewska K, Huckabee MM, Zhou W, Newcomb DC, Fitzgerald GA, Lawson WE, Peebles RS. PGIâ‚‚ signaling inhibits antigen uptake and increases migration of immature dendritic cells. Journal of Leukocyte Biology. 94: 77-88. PMID 23625201 DOI: 10.1189/Jlb.1112559  0.277
2008 Wang M, Lee E, Song W, Ricciotti E, Rader DJ, Lawson JA, Puré E, FitzGerald GA. Microsomal prostaglandin E synthase-1 deletion suppresses oxidative stress and angiotensin II-induced abdominal aortic aneurysm formation. Circulation. 117: 1302-9. PMID 18285567 DOI: 10.1161/Circulationaha.107.731398  0.277
1991 Fitzgerald DJ, Hanson M, FitzGerald GA. Systemic lysis protects against the effects of platelet activation during coronary thrombolysis. The Journal of Clinical Investigation. 88: 1589-95. PMID 1939647 DOI: 10.1172/Jci115471  0.277
1980 Watkins J, FitzGerald G, Zamboulis C, Brown MJ, Dollery CT. Absence of opiate and histamine H2 receptor-mediated effects of clonidine. Clinical Pharmacology and Therapeutics. 28: 605-10. PMID 6254720 DOI: 10.1038/Clpt.1980.210  0.276
1997 Iuliano L, Praticò D, Ferro D, Pittoni V, Valesini G, Lawson J, FitzGerald GA, Violi F. Enhanced lipid peroxidation in patients positive for antiphospholipid antibodies. Blood. 90: 3931-5. PMID 9354660 DOI: 10.1182/Blood.V90.10.3931  0.276
2018 Devchand PR, Liu T, Altman RB, FitzGerald GA, Schadt EE. The Pioglitazone Trek via Human PPAR Gamma: From Discovery to a Medicine at the FDA and Beyond. Frontiers in Pharmacology. 9: 1093. PMID 30337873 DOI: 10.3389/Fphar.2018.01093  0.276
1985 Pedersen AK, FitzGerald GA. Preparation and analysis of deuterium-labeled aspirin: application to pharmacokinetic studies. Journal of Pharmaceutical Sciences. 74: 188-92. PMID 3989690 DOI: 10.1002/Jps.2600740217  0.275
1998 Adiyaman M, Lawson JA, Khanapure SP, FitzGerald GA, Rokach J. Total synthesis of 17,17,18,18-d4-iPF2alpha-VI and quantification of iPF2alpha-VI in human urine by gas chromatography/mass spectrometry. Analytical Biochemistry. 262: 45-56. PMID 9735147 DOI: 10.1006/Abio.1998.2767  0.275
1990 FitzGerald GA, Murray R, Price P, Catella F. The molecular, biochemical and human pharmacology of thromboxane A2 in renal disease. Advances in Experimental Medicine and Biology. 259: 325-60. PMID 2516412 DOI: 10.1007/978-1-4684-5700-1_14  0.274
2006 Ali FY, Egan K, FitzGerald GA, Desvergne B, Wahli W, Bishop-Bailey D, Warner TD, Mitchell JA. Role of prostacyclin versus peroxisome proliferator-activated receptor beta receptors in prostacyclin sensing by lung fibroblasts. American Journal of Respiratory Cell and Molecular Biology. 34: 242-6. PMID 16239641 DOI: 10.1165/Rcmb.2005-0289Oc  0.274
1987 Fitzgerald DJ, Mayo G, Catella F, Entman SS, FitzGerald GA. Increased thromboxane biosynthesis in normal pregnancy is mainly derived from platelets. American Journal of Obstetrics and Gynecology. 157: 325-30. PMID 3618681 DOI: 10.1016/S0002-9378(87)80162-X  0.274
2006 Cannon CP, Curtis SP, FitzGerald GA, Krum H, Kaur A, Bolognese JA, Reicin AS, Bombardier C, Weinblatt ME, van der Heijde D, Erdmann E, Laine L. Cardiovascular outcomes with etoricoxib and diclofenac in patients with osteoarthritis and rheumatoid arthritis in the Multinational Etoricoxib and Diclofenac Arthritis Long-term (MEDAL) programme: a randomised comparison. Lancet. 368: 1771-81. PMID 17113426 DOI: 10.1016/S0140-6736(06)69666-9  0.274
1985 Roy L, Knapp HR, Robertson RM, FitzGerald GA. Endogenous biosynthesis of prostacyclin during cardiac catheterization and angiography in man. Circulation. 71: 434-40. PMID 3882264 DOI: 10.1161/01.Cir.71.3.434  0.273
2004 Praticò D, Rokach J, Lawson J, FitzGerald GA. F2-isoprostanes as indices of lipid peroxidation in inflammatory diseases. Chemistry and Physics of Lipids. 128: 165-71. PMID 15037161 DOI: 10.1016/J.Chemphyslip.2003.09.012  0.273
1986 Patrono C, Ciabattoni G, Pugliese F, Pierucci A, Blair IA, FitzGerald GA. Estimated rate of thromboxane secretion into the circulation of normal humans. The Journal of Clinical Investigation. 77: 590-4. PMID 3944270 DOI: 10.1172/Jci112341  0.273
2020 Di Francesco L, Bruno A, Ricciotti E, Tacconelli S, Dovizio M, Guillem-Llobat P, Alisi MA, Garrone B, Coletta I, Mangano G, Milanese C, FitzGerald GA, Patrignani P. Pharmacological Characterization of the Microsomal Prostaglandin E Synthase-1 Inhibitor AF3485 and . Frontiers in Pharmacology. 11: 374. PMID 32317963 DOI: 10.3389/Fphar.2020.00374  0.273
2006 Curtis AM, Fitzgerald GA. Central and peripheral clocks in cardiovascular and metabolic function. Annals of Medicine. 38: 552-9. PMID 17438670 DOI: 10.1080/07853890600995010  0.273
1996 Praticó D, FitzGerald GA. Generation of 8-epiprostaglandin F2alpha by human monocytes. Discriminate production by reactive oxygen species and prostaglandin endoperoxide synthase-2. The Journal of Biological Chemistry. 271: 8919-24. PMID 8621535 DOI: 10.1074/Jbc.271.15.8919  0.273
2008 Ky B, Burke A, Tsimikas S, Wolfe ML, Tadesse MG, Szapary PO, Witztum JL, FitzGerald GA, Rader DJ. The influence of pravastatin and atorvastatin on markers of oxidative stress in hypercholesterolemic humans. Journal of the American College of Cardiology. 51: 1653-62. PMID 18436117 DOI: 10.1016/J.Jacc.2008.01.026  0.273
2001 FitzGerald GA, Patrono C. The coxibs, selective inhibitors of cyclooxygenase-2. The New England Journal of Medicine. 345: 433-42. PMID 11496855 DOI: 10.1056/Nejm200108093450607  0.273
1991 Clarke RJ, Mayo G, Price P, FitzGerald GA. Suppression of thromboxane A2 but not of systemic prostacyclin by controlled-release aspirin. The New England Journal of Medicine. 325: 1137-41. PMID 1891022 DOI: 10.1097/00006254-199204000-00004  0.272
2018 Mazaleuskaya LL, Salamatipour A, Sarantopoulou D, Weng L, FitzGerald GA, Blair IA, Mesaros C. Analysis of hydroxyeicosatetraenoic acids (HETEs) in human whole blood by chiral ultrahigh performance liquid chromatgraphy (UHPLC)-electron capture atmospheric pressure chemical ionization/high resolution mass spectrometry (ECAPCI/HRMS). Journal of Lipid Research. PMID 29301865 DOI: 10.1194/Jlr.D081414  0.272
1989 Murray R, Furci L, FitzGerald GA. Induction of prostacyclin receptor expression in human erythroleukemia cells. Febs Letters. 255: 172-4. PMID 2477277 DOI: 10.1016/0014-5793(89)81084-1  0.271
1983 Hollister AS, FitzGerald GA, Nadeau JH, Robertson D. Acute reduction in human platelet alpha 2-adrenoreceptor affinity for agonist by endogenous and exogenous catecholamines. The Journal of Clinical Investigation. 72: 1498-505. PMID 6138365 DOI: 10.1172/Jci111106  0.27
2003 Bell-Parikh LC, Ide T, Lawson JA, McNamara P, Reilly M, FitzGerald GA. Biosynthesis of 15-deoxy-delta12,14-PGJ2 and the ligation of PPARgamma. The Journal of Clinical Investigation. 112: 945-55. PMID 12975479 DOI: 10.1172/Jci18012  0.27
1996 Catella-Lawson F, FitzGerald GA. Oxidative stress and platelet activation in diabetes mellitus. Diabetes Research and Clinical Practice. 30: 13-8. PMID 8964187 DOI: 10.1016/S0168-8227(96)80033-7  0.27
2005 Rudic RD, Curtis AM, Cheng Y, FitzGerald G. Peripheral clocks and the regulation of cardiovascular and metabolic function Methods in Enzymology. 393: 524-539. PMID 15817310 DOI: 10.1016/S0076-6879(05)93027-9  0.27
2003 Ide T, Egan K, Bell-Parikh LC, FitzGerald GA. Activation of nuclear receptors by prostaglandins. Thrombosis Research. 110: 311-5. PMID 14592554 DOI: 10.1016/S0049-3848(03)00418-3  0.27
2015 Castro C, Briggs W, Paschos GK, FitzGerald GA, Griffin JL. A metabolomic study of adipose tissue in mice with a disruption of the circadian system. Molecular Biosystems. 11: 1897-906. PMID 25907923 DOI: 10.1039/C5Mb00032G  0.269
2011 Daham K, Song WL, Lawson JA, Kupczyk M, Gülich A, Dahlén SE, FitzGerald GA, Dahlén B. Effects of celecoxib on major prostaglandins in asthma. Clinical and Experimental Allergy : Journal of the British Society For Allergy and Clinical Immunology. 41: 36-45. PMID 20880055 DOI: 10.1111/J.1365-2222.2010.03617.X  0.269
2019 Zhu L, Xu C, Huo X, Hao H, Wan Q, Chen H, Zhang X, Breyer RM, Huang Y, Cao X, Liu DP, FitzGerald GA, Wang M. The cyclooxygenase-1/mPGES-1/endothelial prostaglandin EP4 receptor pathway constrains myocardial ischemia-reperfusion injury. Nature Communications. 10: 1888. PMID 31015404 DOI: 10.1038/S41467-019-09492-4  0.269
1998 Praticò D, Basili S, Vieri M, Cordova C, Violi F, Fitzgerald GA. Chronic obstructive pulmonary disease is associated with an increase in urinary levels of isoprostane F2alpha-III, an index of oxidant stress. American Journal of Respiratory and Critical Care Medicine. 158: 1709-14. PMID 9847257 DOI: 10.1164/Ajrccm.158.6.9709066  0.269
1991 Kerins DM, FitzGerald GA. The current role of platelet-active drugs in ischaemic heart disease. Drugs. 41: 665-71. PMID 1712703 DOI: 10.2165/00003495-199141050-00001  0.268
2013 Hirankarn S, Barrett JS, Alamuddin N, FitzGerald GA, Skarke C. GCG100649, A Novel Cyclooxygenase-2 Inhibitor, Exhibits a Drug Disposition Profile in Healthy Volunteers Compatible With High Affinity to Carbonic Anhydrase-I/II: Preliminary Dose-Exposure Relationships to Define Clinical Development Strategies. Clinical Pharmacology in Drug Development. 2: 379-86. PMID 27121942 DOI: 10.1002/Cpdd.47  0.268
2007 Zhou W, Hashimoto K, Goleniewska K, O'Neal JF, Ji S, Blackwell TS, Fitzgerald GA, Egan KM, Geraci MW, Peebles RS. Prostaglandin I2 analogs inhibit proinflammatory cytokine production and T cell stimulatory function of dendritic cells. Journal of Immunology (Baltimore, Md. : 1950). 178: 702-10. PMID 17202330 DOI: 10.4049/Jimmunol.178.2.702  0.268
2012 Paschos GK, Ibrahim S, Song WL, Kunieda T, Grant G, Reyes TM, Bradfield CA, Vaughan CH, Eiden M, Masoodi M, Griffin JL, Wang F, Lawson JA, Fitzgerald GA. Obesity in mice with adipocyte-specific deletion of clock component Arntl. Nature Medicine. 18: 1768-77. PMID 23142819 DOI: 10.1038/Nm.2979  0.268
1996 Vezza R, Habib A, Li H, Lawson JA, FitzGerald GA. Regulation of cyclooxygenases by protein kinase C. Evidence against the importance of direct enzyme phosphorylation. The Journal of Biological Chemistry. 271: 30028-33. PMID 8939949 DOI: 10.1074/Jbc.271.47.30028  0.268
2011 Zhou W, Dowell D, Huckabee M, Newcomb D, Goleniewska K, FitzGerald G, Peebles Jr. R. The Deficiency of PGI2 Signaling Induces STAT6-independent Allergic Airway Inflammation Journal of Allergy and Clinical Immunology. 127: AB57-AB57. DOI: 10.1016/J.Jaci.2010.12.237  0.267
1984 Watson ML, Goodman RP, Gill JR, Branch RA, Brash AR, Fitzgerald GA. Endogenous prostacyclin synthesis is decreased during activation of the renin-angiotensin system in man Journal of Clinical Endocrinology and Metabolism. 58: 304-308. PMID 6363436 DOI: 10.1210/Jcem-58-2-304  0.267
1981 Robertson RM, Robertson D, Roberts LJ, Maas RL, FitzGerald GA, Friesinger GC, Oates JA. Thromboxane A2 in vasotonic angina pectoris: evidence from direct measurements and inhibitor trials. The New England Journal of Medicine. 304: 998-1003. PMID 7010173 DOI: 10.1056/Nejm198104233041703  0.267
1997 Leo R, Praticò D, Iuliano L, Pulcinelli FM, Ghiselli A, Pignatelli P, Colavita AR, FitzGerald GA, Violi F. Platelet activation by superoxide anion and hydroxyl radicals intrinsically generated by platelets that had undergone anoxia and then reoxygenated. Circulation. 95: 885-91. PMID 9054746 DOI: 10.1161/01.Cir.95.4.885  0.267
1990 FitzGerald GA, Lupinetti M, Charman SA, Charman WN. Presystemic acetylation of platelet cyclooxygenase: Selective inhibition by controlled release-low dose aspirin Journal of the American College of Cardiology. 15: A160. DOI: 10.1016/0735-1097(90)92356-7  0.267
2010 Paschos GK, FitzGerald GA. Circadian clocks and vascular function. Circulation Research. 106: 833-41. PMID 20299673 DOI: 10.1161/Circresaha.109.211706  0.266
2011 Toki S, Zhou W, Goleniewska K, FitzGerald G, Peebles Jr. R. Prostaglandin I2 Receptor (IP) Signaling Inhibits TLR4 Cell Surface Expression and Reduces LPS-induced Lung Inflammation Journal of Allergy and Clinical Immunology. 127: AB92-AB92. DOI: 10.1016/J.Jaci.2010.12.371  0.265
2018 Lin N, Shay JES, Xie H, Lee DSM, Skuli N, Tang Q, Zhou Z, Azzam A, Meng H, Wang H, FitzGerald GA, Simon MC. Myeloid Cell Hypoxia-Inducible Factors Promote Resolution of Inflammation in Experimental Colitis. Frontiers in Immunology. 9: 2565. PMID 30455703 DOI: 10.3389/Fimmu.2018.02565  0.265
2015 Skarke C, Alamuddin N, Lawson JA, Li X, Ferguson JF, Reilly MP, FitzGerald GA. Bioactive products formed in humans from fish oils. Journal of Lipid Research. 56: 1808-20. PMID 26180051 DOI: 10.1194/Jlr.M060392  0.265
2019 Markosyan N, Li J, Sun Y, Richman L, Lin J, Yan F, Quinones L, Sela Y, Yamazoe T, Gordon N, Tobias J, Byrne K, Rech A, FitzGerald G, Stanger B, et al. Abstract B33: Tumor cell-intrinsic EPHA2 suppresses antitumor immunity by regulating PTGS2 (COX-2) in pancreatic adenocarcinoma Immunotherapy. 79. DOI: 10.1158/1538-7445.Panca19-B33  0.265
1992 Kunitada S, FitzGerald G, Fitzgerald D. Inhibition of clot lysis and decreased binding of tissue-type plasminogen activator as a consequence of clot retraction Blood. 79: 1420-1427. DOI: 10.1182/Blood.V79.6.1420.Bloodjournal7961420  0.265
2003 Ferro D, Saliola M, Meroni PL, Valesini G, Caroselli C, Praticò D, Fitzgerald GA, Shoenfeld Y, Violi F. Enhanced monocyte expression of tissue factor by oxidative stress in patients with antiphospholipid antibodies: effect of antioxidant treatment. Journal of Thrombosis and Haemostasis : Jth. 1: 523-31. PMID 12871461 DOI: 10.1046/J.1538-7836.2003.00108.X  0.264
2001 Cyrus T, Praticò D, Zhao L, Witztum JL, Rader DJ, Rokach J, FitzGerald GA, Funk CD. Absence of 12/15-lipoxygenase expression decreases lipid peroxidation and atherogenesis in apolipoprotein e-deficient mice. Circulation. 103: 2277-82. PMID 11342477 DOI: 10.1161/01.Cir.103.18.2277  0.264
2018 Song WL, Ricciotti E, Liang X, Grosser T, Grant GR, FitzGerald GA. L-Pgds but not H-Pgds deletion causes hypertension and accelerates thrombogenesis in mice. The Journal of Pharmacology and Experimental Therapeutics. PMID 30305427 DOI: 10.1124/Jpet.118.250936  0.264
2004 Hashimoto K, Graham BS, Geraci MW, FitzGerald GA, Egan K, Zhou W, Goleniewska K, O'Neal JF, Morrow JD, Durbin RK, Wright PF, Collins RD, Suzutani T, Peebles RS. Signaling through the prostaglandin I2 receptor IP protects against respiratory syncytial virus-induced illness. Journal of Virology. 78: 10303-9. PMID 15367596 DOI: 10.1128/Jvi.78.19.10303-10309.2004  0.263
2008 FitzGerald GA. Translational therapeutics at the platelet vascular interface. Summary. Arteriosclerosis, Thrombosis, and Vascular Biology. 28: s51-2. PMID 18296588 DOI: 10.1161/Atvbaha.108.162206  0.263
1982 FitzGerald GA, Brash AR, Falardeau P, Oates JA. Estimated rate of prostacyclin secretion into the circulation of normal man. The Journal of Clinical Investigation. 68: 1272-6. PMID 7028786 DOI: 10.1172/Jci110373  0.263
2018 Paschos GK, Tang SY, Theken KN, Li X, Verginadis I, Lekkas D, Herman L, Yan W, Lawson J, FitzGerald GA. Cold-Induced Browning of Inguinal White Adipose Tissue Is Independent of Adipose Tissue Cyclooxygenase-2. Cell Reports. 24: 809-814. PMID 30044978 DOI: 10.1016/J.Celrep.2018.06.082  0.263
2007 Zhou W, Blackwell TS, Goleniewska K, O'Neal JF, Fitzgerald GA, Lucitt M, Breyer RM, Peebles RS. Prostaglandin I2 analogs inhibit Th1 and Th2 effector cytokine production by CD4 T cells. Journal of Leukocyte Biology. 81: 809-17. PMID 17135575 DOI: 10.1189/Jlb.0606375  0.263
1998 Baughman RA, Kapoor SC, Agarwal RK, Kisicki J, Catella-Lawson F, FitzGerald GA. Oral delivery of anticoagulant doses of heparin. A randomized, double-blind, controlled study in humans. Circulation. 98: 1610-5. PMID 9778325 DOI: 10.1161/01.Cir.98.16.1610  0.263
2006 Woon PY, Curtis AM, Kaisaki PJ, Argoud K, Wallace KJ, Bihoreau MT, FitzGerald GA, Gauguier D. Genomic organization of the rat Clock gene and sequence analysis in inbred rat strains. Genomics. 87: 208-17. PMID 16376516 DOI: 10.1016/J.Ygeno.2005.10.006  0.262
2008 FitzGerald GA. Translational therapeutics at the platelet vascular interface. Introduction. Arteriosclerosis, Thrombosis, and Vascular Biology. 28: s3-4. PMID 18296587 DOI: 10.1161/Atvbaha.108.162198  0.262
2005 Kadiiska MB, Gladen BC, Baird DD, Germolec D, Graham LB, Parker CE, Nyska A, Wachsman JT, Ames BN, Basu S, Brot N, Fitzgerald GA, Floyd RA, George M, Heinecke JW, et al. Biomarkers of oxidative stress study II: are oxidation products of lipids, proteins, and DNA markers of CCl4 poisoning? Free Radical Biology & Medicine. 38: 698-710. PMID 15721980 DOI: 10.1016/J.Freeradbiomed.2004.09.017  0.262
2009 Chang CT, Patel P, Gore V, Song WL, Lawson JA, Powell WS, Fitzgerald GA, Rokach J. A new approach to the synthesis of polyunsaturated deuterated isoprostanes: total synthesis of d4-5-epi-8,12-iso-iPF3alpha-VI and d4-8,12-iso-iPF3alpha-VI. Bioorganic & Medicinal Chemistry Letters. 19: 6755-8. PMID 19846297 DOI: 10.1016/J.Bmcl.2009.09.099  0.262
2019 Yang G, Chen L, Zhang J, Ren B, FitzGerald GA. Bmal1 deletion in mice facilitates adaptation to disrupted light/dark conditions. Jci Insight. 5. PMID 30973828 DOI: 10.1172/Jci.Insight.125133  0.262
1990 Fitzgerald DJ, Rocki W, Murray R, Mayo G, FitzGerald GA. Thromboxane A2 synthesis in pregnancy-induced hypertension. Lancet (London, England). 335: 751-4. PMID 1969511 DOI: 10.1016/0020-7292(91)90552-G  0.261
2015 Liang X, Bushman FD, FitzGerald GA. Rhythmicity of the intestinal microbiota is regulated by gender and the host circadian clock. Proceedings of the National Academy of Sciences of the United States of America. 112: 10479-84. PMID 26240359 DOI: 10.1073/Pnas.1501305112  0.261
2009 Song WL, Paschos G, Fries S, Reilly MP, Yu Y, Rokach J, Chang CT, Patel P, Lawson JA, Fitzgerald GA. Novel eicosapentaenoic acid-derived F3-isoprostanes as biomarkers of lipid peroxidation. The Journal of Biological Chemistry. 284: 23636-43. PMID 19520854 DOI: 10.1074/Jbc.M109.024075  0.26
2014 Daham K, James A, Balgoma D, Kupczyk M, Billing B, Lindeberg A, Henriksson E, FitzGerald GA, Wheelock CE, Dahlén SE, Dahlén B. Effects of selective COX-2 inhibition on allergen-induced bronchoconstriction and airway inflammation in asthma. The Journal of Allergy and Clinical Immunology. 134: 306-13. PMID 24461582 DOI: 10.1016/J.Jaci.2013.12.002  0.26
1992 Funk CD, Funk LB, FitzGerald GA, Samuelsson B. Characterization of human 12-lipoxygenase genes. Proceedings of the National Academy of Sciences of the United States of America. 89: 3962-6. PMID 1570320 DOI: 10.1073/Pnas.89.9.3962  0.259
2007 North TE, Goessling W, Walkley CR, Lengerke C, Kopani KR, Lord AM, Weber GJ, Bowman TV, Jang IH, Grosser T, Fitzgerald GA, Daley GQ, Orkin SH, Zon LI. Prostaglandin E2 regulates vertebrate haematopoietic stem cell homeostasis. Nature. 447: 1007-11. PMID 17581586 DOI: 10.1038/Nature05883  0.259
1999 Ferro D, Basili S, Praticó D, Iuliano L, FitzGerald GA, Violi F. Vitamin E reduces monocyte tissue factor expression in cirrhotic patients. Blood. 93: 2945-50. PMID 10216089 DOI: 10.1182/Blood.V93.9.2945  0.259
2000 Christofidou-Solomidou M, Pietra GG, Solomides CC, Arguiris E, Harshaw D, Fitzgerald GA, Albelda SM, Muzykantov VR. Immunotargeting of glucose oxidase to endothelium in vivo causes oxidative vascular injury in the lungs. American Journal of Physiology. Lung Cellular and Molecular Physiology. 278: L794-805. PMID 10749757 DOI: 10.1152/Ajplung.2000.278.4.L794  0.259
1988 Jackson EK, Goto F, Uderman HD, Workman RJ, Herzer WA, FitzGerald GA, Branch RA. Effects of thromboxane synthase inhibitors on renal function. Naunyn-Schmiedeberg's Archives of Pharmacology. 337: 183-90. PMID 3285227 DOI: 10.1007/Bf00169247  0.259
2012 Toki S, Goleniewska K, FitzGerald G, Peebles R. Prostaglandin I2 Receptor (IP) Signaling Inhibits Antigen Uptake but Induce the Ability of Migration on Immature Dendritic Cells Journal of Allergy and Clinical Immunology. 129: AB161. DOI: 10.1016/J.Jaci.2011.12.365  0.258
2005 Furberg CD, Psaty BM, FitzGerald GA. Parecoxib, valdecoxib, and cardiovascular risk. Circulation. 111: 249. PMID 15655125 DOI: 10.1161/01.Cir.0000155081.76164.17  0.258
2014 FitzGerald GA. Circadian Rhythms. Temporal targets of drug action. Science (New York, N.Y.). 346: 921-2. PMID 25414292 DOI: 10.1126/Science.Aaa2285  0.258
1997 Reilly MP, Delanty N, Roy L, Rokach J, Callaghan PO, Crean P, Lawson JA, FitzGerald GA. Increased formation of the isoprostanes IPF2alpha-I and 8-epi-prostaglandin F2alpha in acute coronary angioplasty: evidence for oxidant stress during coronary reperfusion in humans. Circulation. 96: 3314-20. PMID 9396422 DOI: 10.1161/01.Cir.96.10.3314  0.257
1980 Hossmann V, Fitzgerald GA, Dollery CT. Circadian rhythm of baroreflex reactivity and adrenergic vascular response. Cardiovascular Research. 14: 125-9. PMID 7397713 DOI: 10.1093/Cvr/14.3.125  0.257
2013 Grosser T, Fries S, Lawson JA, Kapoor SC, Grant GR, Fitzgerald GA. Response to letters regarding article, "Drug resistance and pseudoresistance: an unintended consequence of enteric coating aspirin". Circulation. 128: e191. PMID 24043153 DOI: 10.1161/Circulationaha.113.004750  0.257
2008 Chang CT, Patel P, Kang N, Lawson JA, Song WL, Powell WS, FitzGerald GA, Rokach J. Eicosapentaenoic-acid-derived isoprostanes: synthesis and discovery of two major isoprostanes. Bioorganic & Medicinal Chemistry Letters. 18: 5523-7. PMID 18804370 DOI: 10.1016/J.Bmcl.2008.09.008  0.256
2007 Jaffar Z, Ferrini ME, Buford MC, Fitzgerald GA, Roberts K. Prostaglandin I2-IP signaling blocks allergic pulmonary inflammation by preventing recruitment of CD4+ Th2 cells into the airways in a mouse model of asthma. Journal of Immunology (Baltimore, Md. : 1950). 179: 6193-203. PMID 17947695 DOI: 10.4049/Jimmunol.179.9.6193  0.256
1987 Wennmalm M, FitzGerald GA, Wennmalm A. Prostacyclin as neuromodulator in the sympathetically stimulated rabbit heart. Prostaglandins. 33: 675-91. PMID 2884696 DOI: 10.1016/0090-6980(87)90034-7  0.255
2014 FitzGerald GA. Testing cardiovascular drug safety and efficacy in randomized trials. Circulation Research. 114: 1156-61. PMID 24677235 DOI: 10.1161/Circresaha.114.301809  0.255
2013 Grosser T, Fries S, Lawson JA, Kapoor SC, Grant GR, FitzGerald GA. Drug resistance and pseudoresistance: an unintended consequence of enteric coating aspirin. Circulation. 127: 377-85. PMID 23212718 DOI: 10.1161/Circulationaha.112.117283  0.255
1994 Dworski R, Fitzgerald GA, Oates JA, Sheller JR. Effect of oral prednisone on airway inflammatory mediators in atopic asthma. American Journal of Respiratory and Critical Care Medicine. 149: 953-9. PMID 8143061 DOI: 10.1164/Ajrccm.149.4.8143061  0.255
2020 Sengupta S, Brooks TG, Grant GR, FitzGerald GA. Accounting for Time: Circadian Rhythms in the Time of COVID-19. Journal of Biological Rhythms. 748730420953335. PMID 32875944 DOI: 10.1177/0748730420953335  0.254
2011 Jaffar Z, Ferrini ME, Shaw PK, FitzGerald GA, Roberts K. Prostaglandin Iâ‚‚promotes the development of IL-17-producing γδ T cells that associate with the epithelium during allergic lung inflammation. Journal of Immunology (Baltimore, Md. : 1950). 187: 5380-91. PMID 21976777 DOI: 10.4049/Jimmunol.1101261  0.253
2015 Greene CS, Krishnan A, Wong AK, Ricciotti E, Zelaya RA, Himmelstein DS, Zhang R, Hartmann BM, Zaslavsky E, Sealfon SC, Chasman DI, FitzGerald GA, Dolinski K, Grosser T, Troyanskaya OG. Understanding multicellular function and disease with human tissue-specific networks. Nature Genetics. 47: 569-76. PMID 25915600 DOI: 10.1038/Ng.3259  0.253
1988 Oates JA, FitzGerald GA, Branch RA, Jackson EK, Knapp HR, Roberts LJ. Clinical implications of prostaglandin and thromboxane A2 formation (1). The New England Journal of Medicine. 319: 689-98. PMID 3045550 DOI: 10.1056/Nejm198809153191106  0.253
1993 Harker LA, Kelly AB, Hanson SR, Krupski W, Bass A, Osterud B, FitzGerald GA, Goodnight SH, Connor WE. Interruption of vascular thrombus formation and vascular lesion formation by dietary n-3 fatty acids in fish oil in nonhuman primates. Circulation. 87: 1017-29. PMID 8443878 DOI: 10.1161/01.Cir.87.3.1017  0.253
1998 Rader DJ, FitzGerald GA. State of the art: atherosclerosis in a limited edition. Nature Medicine. 4: 899-900. PMID 9701240 DOI: 10.1038/Nm0898-899  0.252
2004 Rokach J, Kim S, Bellone S, Lawson JA, Praticò D, Powell WS, FitzGerald GA. Total synthesis of isoprostanes: discovery and quantitation in biological systems. Chemistry and Physics of Lipids. 128: 35-56. PMID 15037151 DOI: 10.1016/J.Chemphyslip.2003.09.011  0.252
2015 Mazaleuskaya LL, Sangkuhl K, Thorn CF, FitzGerald GA, Altman RB, Klein TE. PharmGKB summary: pathways of acetaminophen metabolism at the therapeutic versus toxic doses. Pharmacogenetics and Genomics. 25: 416-26. PMID 26049587 DOI: 10.1097/Fpc.0000000000000150  0.251
2002 FitzGerald GA. Nonsteroidal anti-inflammatory drugs, coxibs, and cardio-renal physiology: a mechanism-based approach. The American Journal of Cardiology. 89: 1D-2D. PMID 11909554 DOI: 10.1016/S0002-9149(02)02230-0  0.25
2012 Olson MT, Kickler TS, Lawson JA, McLean RC, Jani J, FitzGerald GA, Rade JJ. Effect of assay specificity on the association of urine 11-dehydro thromboxane B2 determination with cardiovascular risk. Journal of Thrombosis and Haemostasis : Jth. 10: 2462-9. PMID 23072449 DOI: 10.1111/Jth.12026  0.25
2014 Skarke C, FitzGerald GA. Selective COX-2 inhibitors suppress prostacyclin. Clinical Therapeutics. 36: 2120-1. PMID 25450471 DOI: 10.1016/J.Clinthera.2014.09.024  0.25
2001 Meagher EA, Barry OP, Lawson JA, Rokach J, FitzGerald GA. Effects of vitamin E on lipid peroxidation in healthy persons. Jama. 285: 1178-82. PMID 11231747 DOI: 10.1001/Jama.285.9.1178  0.25
1990 Catella F, FitzGerald GA. Measurement of thromboxane metabolites by gas chromatography-mass spectrometry. Methods in Enzymology. 187: 42-50. PMID 2233356 DOI: 10.1016/0076-6879(90)87007-P  0.249
2012 Zhou W, Dowell DR, Huckabee MM, Newcomb DC, Boswell MG, Goleniewska K, Lotz MT, Toki S, Yin H, Yao S, Natarajan C, Wu P, Sriram S, Breyer RM, Fitzgerald GA, et al. Prostaglandin I2 signaling drives Th17 differentiation and exacerbates experimental autoimmune encephalomyelitis. Plos One. 7: e33518. PMID 22590492 DOI: 10.1371/Journal.Pone.0033518  0.249
2010 FitzGerald GA. Perestroika in pharma: evolution or revolution in drug development? The Mount Sinai Journal of Medicine, New York. 77: 327-32. PMID 20687177 DOI: 10.1002/Msj.20198  0.249
1998 Reilly MP, Praticò D, Delanty N, DiMinno G, Tremoli E, Rader D, Kapoor S, Rokach J, Lawson J, FitzGerald GA. Increased formation of distinct F2 isoprostanes in hypercholesterolemia. Circulation. 98: 2822-8. PMID 9860782 DOI: 10.1161/01.Cir.98.25.2822  0.248
1996 Reilly M, Delanty N, Lawson JA, FitzGerald GA. Modulation of oxidant stress in vivo in chronic cigarette smokers. Circulation. 94: 19-25. PMID 8964113 DOI: 10.1161/01.Cir.94.1.19  0.248
1989 Knapp HR, FitzGerald GA. The antihypertensive effects of fish oil. A controlled study of polyunsaturated fatty acid supplements in essential hypertension. The New England Journal of Medicine. 320: 1037-43. PMID 2648152 DOI: 10.1056/Nejm198904203201603  0.248
2006 Lawson JA, Kim S, Powell WS, FitzGerald GA, Rokach J. Oxidized derivatives of omega-3 fatty acids: identification of IPF3 alpha-VI in human urine. Journal of Lipid Research. 47: 2515-24. PMID 16943517 DOI: 10.1194/Jlr.M600327-Jlr200  0.248
1992 Kerins DM, FitzGerald GA. Arachidonic Acid Metabolism, Platelets, and Thromboembolic Disease Handbook of Experimental Pharmacology. 101: 299-351. DOI: 10.1007/978-3-642-75865-2_9  0.247
1990 Lellouche F, Fradin A, Fitzgerald G, Maclouf J. Enzyme immunoassay measurement of the urinary metabolites of thromboxane A2 and prostacyclin Prostaglandins. 40: 297-310. PMID 2247619 DOI: 10.1016/0090-6980(90)90017-P  0.247
1987 Fitzgerald DJ, Entman SS, Mulloy K, FitzGerald GA. Decreased prostacyclin biosynthesis preceding the clinical manifestation of pregnancy-induced hypertension. Circulation. 75: 956-63. PMID 3552297 DOI: 10.1161/01.Cir.75.5.956  0.247
2017 Grosser T, Theken KN, FitzGerald GA. Cyclooxygenase inhibition: Pain, inflammation and the cardiovascular system. Clinical Pharmacology and Therapeutics. PMID 28710775 DOI: 10.1002/Cpt.794  0.247
2009 Vardeh D, Wang D, Costigan M, Lazarus M, Saper CB, Woolf CJ, Fitzgerald GA, Samad TA. COX2 in CNS neural cells mediates mechanical inflammatory pain hypersensitivity in mice. The Journal of Clinical Investigation. 119: 287-94. PMID 19127021 DOI: 10.1172/Jci37098  0.246
2018 Kress GJ, Liao F, Dimitry J, Cedeno MR, FitzGerald GA, Holtzman DM, Musiek ES. Regulation of amyloid-β dynamics and pathology by the circadian clock. The Journal of Experimental Medicine. PMID 29382695 DOI: 10.1084/Jem.20172347  0.246
2013 Toki S, Reiss S, Goleniewska K, Moore ML, FitzGerald G, Peebles RS. Prostaglandin I2 Receptor (IP) Signaling Inhibits Lung Type I Interferon Expression by RSV Infection Journal of Allergy and Clinical Immunology. 131: AB191. DOI: 10.1016/J.Jaci.2012.12.1348  0.246
1983 Feldman RD, Limbird LE, Nadeau J, FitzGerald GA, Robertson D, Wood AJ. Dynamic regulation of leukocyte beta adrenergic receptor-agonist interactions by physiological changes in circulating catecholamines. The Journal of Clinical Investigation. 72: 164-70. PMID 6308044 DOI: 10.1172/Jci110954  0.245
1999 Al-Abed Y, Mitsuhashi T, Li H, Lawson JA, FitzGerald GA, Founds H, Donnelly T, Cerami A, Ulrich P, Bucala R. Inhibition of advanced glycation endproduct formation by acetaldehyde: role in the cardioprotective effect of ethanol. Proceedings of the National Academy of Sciences of the United States of America. 96: 2385-90. PMID 10051651 DOI: 10.1073/Pnas.96.5.2385  0.245
2012 Fitzgerald DJ, Fitzgerald GA. Antiplatelet and anticoagulant therapy during coronary thrombolysis. Trends in Cardiovascular Medicine. 1: 29-35. PMID 21239343 DOI: 10.1016/1050-1738(91)90056-K  0.245
2003 FitzGerald GA. Correction: Cox-2 and beyond: Approaches to prostagland in inhibition in human disease Nature Reviews Drug Discovery. 2: 1030-1030. DOI: 10.1038/Nrd1264  0.244
1981 Hossmann V, FitzGerald GA, Dollery CT. Influence of hospitalization and placebo therapy on blood pressure and sympathetic function in essential hypertension. Hypertension (Dallas, Tex. : 1979). 3: 113-8. PMID 7009424 DOI: 10.1161/01.Hyp.3.1.113  0.243
2001 Iuliano L, Praticò D, Greco C, Mangieri E, Scibilia G, FitzGerald GA, Violi F. Angioplasty increases coronary sinus F2-isoprostane formation: evidence for in vivo oxidative stress during PTCA. Journal of the American College of Cardiology. 37: 76-80. PMID 11153776 DOI: 10.1016/S0735-1097(00)01040-8  0.243
1988 FitzGerald GA, Oates JA, Nowak J. Cigarette smoking and hemostatic function. American Heart Journal. 115: 267-71. PMID 3276116 DOI: 10.1016/0002-8703(88)90648-5  0.242
2019 Sengupta S, Tang SY, Devine JC, Anderson ST, Nayak S, Zhang SL, Valenzuela A, Fisher DG, Grant GR, López CB, FitzGerald GA. Circadian control of lung inflammation in influenza infection. Nature Communications. 10: 4107. PMID 31511530 DOI: 10.1038/S41467-019-11400-9  0.242
1987 Ciabattoni G, Maclouf J, Catella F, FitzGerald GA, Patrono C. Radioimmunoassay of 11-dehydrothromboxane B2 in human plasma and urine. Biochimica Et Biophysica Acta. 918: 293-7. PMID 3567215 DOI: 10.1016/0005-2760(87)90233-5  0.242
1992 Goodnight SH, Cairns JA, Fisher M, FitzGerald GA. Assessment of the therapeutic use of n-3 fatty acids in vascular disease and thrombosis. Chest. 102: 374S-384S. PMID 1395822 DOI: 10.1378/Chest.102.4_Supplement.374S  0.242
2017 Liang X, FitzGerald GA. Timing the Microbes: The Circadian Rhythm of the Gut Microbiome. Journal of Biological Rhythms. 748730417729066. PMID 28862076 DOI: 10.1177/0748730417729066  0.242
1984 Pedersen AK, Watson ML, Fitzgerald GA. Inhibition of thromboxane biosynthesis in serum: Limitations of the measurement of immunoreactive 6-KETO-PGF1α Thrombosis Research. 33: 99-103. PMID 6546456 DOI: 10.1016/0049-3848(84)90159-2  0.242
2002 Rocca B, FitzGerald GA. Cyclooxygenases and prostaglandins: shaping up the immune response. International Immunopharmacology. 2: 603-30. PMID 12013502 DOI: 10.1016/S1567-5769(01)00204-1  0.242
2017 Paschos GK, FitzGerald GA. Circadian Clocks and Metabolism: Implications for Microbiome and Aging. Trends in Genetics : Tig. PMID 28844699 DOI: 10.1016/J.Tig.2017.07.010  0.241
2005 Francois H, Athirakul K, Howell D, Dash R, Mao L, Kim H, Rockman HA, FitzGerald GA, Koller BH, Coffman TM. NSAIDs and cardiovascular risk—Reply Cell Metabolism. 2: 340. DOI: 10.1016/J.Cmet.2005.11.008  0.241
1999 Meagher EA, Barry OP, Burke A, Lucey MR, Lawson JA, Rokach J, FitzGerald GA. Alcohol-induced generation of lipid peroxidation products in humans. The Journal of Clinical Investigation. 104: 805-13. PMID 10491416 DOI: 10.1172/Jci5584  0.241
2019 Sarantopoulou D, Tang SY, Ricciotti E, Lahens NF, Lekkas D, Schug J, Guo XS, Paschos GK, FitzGerald GA, Pack AI, Grant GR. Comparative evaluation of RNA-Seq library preparation methods for strand-specificity and low input. Scientific Reports. 9: 13477. PMID 31530843 DOI: 10.1038/S41598-019-49889-1  0.24
1983 FitzGerald GA, Pedersen AK, Patrono C. Analysis of prostacyclin and thromboxane biosynthesis in cardiovascular disease. Circulation. 67: 1174-7. PMID 6342834 DOI: 10.1161/01.Cir.67.6.1174  0.24
2007 Huang JC, Wun WS, Goldsby JS, Egan K, FitzGerald GA, Wu KK. Prostacyclin receptor signaling and early embryo development in the mouse. Human Reproduction (Oxford, England). 22: 2851-6. PMID 17905746 DOI: 10.1093/Humrep/Dem304  0.24
2020 Melamud E, Taylor DL, Sethi A, Cule M, Baryshnikova A, Saleheen D, van Bruggen N, FitzGerald GA. The promise and reality of therapeutic discovery from large cohorts. The Journal of Clinical Investigation. PMID 31929188 DOI: 10.1172/Jci129196  0.24
2011 FitzGerald GA. Regulatory science: what it is and why we need it. Clinical Pharmacology and Therapeutics. 89: 291-4. PMID 21160470 DOI: 10.1038/Clpt.2010.276  0.24
2014 Song W, Stubbe J, Ricciotti E, Dunbar RL, Rader DJ, FitzGerald GA. Systemic Eicosanoid and Cytokine Response to Niacin: Implications in HPS2-THRIVE Trial and Beyond†∗ Journal of Clinical Lipidology. 8: 309-310. DOI: 10.1016/J.Jacl.2014.02.030  0.239
2007 FitzGerald G. The devil’s doctor: Paracelsus and the world of Renaissance magic and science Journal of Clinical Investigation. 117: 512-512. DOI: 10.1172/Jci31235  0.239
1980 FitzGerald GA, Hossmann V, Hamilton CA, Reid JL, Davies DS, Dollery CT. Interindividual variation in kinetics of infused epinephrine. Clinical Pharmacology and Therapeutics. 26: 669-75. PMID 498709 DOI: 10.1002/Cpt1979266669  0.238
1997 Rokach J, Khanapure SP, Hwang SW, Adiyaman M, Lawson JA, FitzGerald GA. Nomenclature of isoprostanes: a proposal. Prostaglandins. 54: 853-73. PMID 9533181 DOI: 10.1016/S0090-6980(97)00184-6  0.238
1997 Adiyaman M, Li H, Lawson JA, Hwang SW, Khanapure SP, FitzGerald GA, Rokach J. First total synthesis of isoprostane IPF(2α)-III Tetrahedron Letters. 38: 3339-3342. DOI: 10.1016/S0040-4039(97)00622-9  0.238
2010 Skarke C, FitzGerald GA. Training translators for smart drug discovery. Science Translational Medicine. 2: 26cm12. PMID 20375362 DOI: 10.1126/Scitranslmed.3000890  0.238
1999 Li H, Lawson JA, Reilly M, Adiyaman M, Hwang SW, Rokach J, FitzGerald GA. Quantitative high performance liquid chromatography/tandem mass spectrometric analysis of the four classes of F(2)-isoprostanes in human urine. Proceedings of the National Academy of Sciences of the United States of America. 96: 13381-6. PMID 10557329 DOI: 10.1073/Pnas.96.23.13381  0.238
2019 Markosyan N, Li J, Sun YH, Richman LP, Lin JH, Yan F, Quinones L, Sela Y, Yamazoe T, Gordon N, Tobias JW, Byrne KT, Rech AJ, FitzGerald GA, Stanger BZ, et al. Tumor cell-intrinsic EPHA2 suppresses anti-tumor immunity by regulating PTGS2 (COX-2). The Journal of Clinical Investigation. 130. PMID 31162144 DOI: 10.1172/Jci127755  0.237
2015 Curtis AM, Fagundes CT, Yang G, Palsson-McDermott EM, Wochal P, McGettrick AF, Foley NH, Early JO, Chen L, Zhang H, Xue C, Geiger SS, Hokamp K, Reilly MP, Coogan AN, ... ... FitzGerald GA, et al. Circadian control of innate immunity in macrophages by miR-155 targeting Bmal1. Proceedings of the National Academy of Sciences of the United States of America. 112: 7231-6. PMID 25995365 DOI: 10.1073/Pnas.1501327112  0.237
2009 Greenbaum DC, FitzGerald GA. Platelets, pyrexia, and plasmodia. The New England Journal of Medicine. 361: 526-8. PMID 19641212 DOI: 10.1056/Nejmcibr0903050  0.237
2005 Fitzgerald GA. Opinion: anticipating change in drug development: the emerging era of translational medicine and therapeutics. Nature Reviews. Drug Discovery. 4: 815-8. PMID 16224453 DOI: 10.1038/Nrd1849  0.236
1990 FitzGerald GA. Ticlopidine in unstable angina. A more expensive aspirin? Circulation. 82: 296-298. PMID 2114237 DOI: 10.1161/01.Cir.82.1.296  0.236
2001 Kim S, Jung YJ, Lawson JA, FitzGerald GA, Rokach J. iPF2α-III metabolism. First total synthesis of 2,3-dinor iPF2α-III, a primary β-oxidation metabolite Tetrahedron Letters. 42: 8277-8280. DOI: 10.1016/S0040-4039(01)01794-4  0.236
2007 Song WL, Lawson JA, Wang M, Zou H, FitzGerald GA. Noninvasive assessment of the role of cyclooxygenases in cardiovascular health: a detailed HPLC/MS/MS method. Methods in Enzymology. 433: 51-72. PMID 17954228 DOI: 10.1016/S0076-6879(07)33003-6  0.236
2001 McNamara P, FitzGerald GA. Smoking-induced vascular disease: a new twist on an old theme. Circulation Research. 89: 563-5. PMID 11577020 DOI: 10.1161/Res.89.7.563  0.236
1985 Lawson JA, Brash AR, Doran J, FitzGerald GA. Measurement of urinary 2,3-dinor-thromboxane B2 and thromboxane B2 using bonded-phase phenylboronic acid columns and capillary gas chromatography-negative-ion chemical ionization mass spectrometry Analytical Biochemistry. 150: 463-470. PMID 4091270 DOI: 10.1016/0003-2697(85)90536-6  0.235
2015 Mazaleuskaya LL, Theken KN, Gong L, Thorn CF, FitzGerald GA, Altman RB, Klein TE. PharmGKB summary: ibuprofen pathways. Pharmacogenetics and Genomics. 25: 96-106. PMID 25502615 DOI: 10.1097/Fpc.0000000000000113  0.235
1998 Pudukulathan Z, Manna S, Hwang SW, Khanapure SP, Lawson JA, FitzGerald GA, Rokach J. Diels-Alder approach to isoprostanes. Total synthesis of iPF(2α)-V Journal of the American Chemical Society. 120: 11953-11961. DOI: 10.1021/Ja982596K  0.235
1999 Praticò D, Ferro D, Iuliano L, Rokach J, Conti F, Valesini G, FitzGerald GA, Violi F. Ongoing prothrombotic state in patients with antiphospholipid antibodies: a role for increased lipid peroxidation. Blood. 93: 3401-7. PMID 10233892 DOI: 10.1182/Blood.V93.10.3401.410K36_3401_3407  0.234
1987 Fisher KL, FitzGerald GA, Lawn RM. Two polymorphisms in the human lipoprotein lipase (LPL) gene. Nucleic Acids Research. 15: 7657. PMID 2889196 DOI: 10.1093/Nar/15.18.7657  0.234
2017 Desai BN, Singhal G, Watanabe M, Stevanovic D, Lundasen T, Fisher FM, Mather ML, Vardeh HG, Douris N, Adams AC, Nasser IA, FitzGerald GA, Flier JS, Skarke C, Maratos-Flier E. Fibroblast growth factor 21 (FGF21) is robustly induced by ethanol and has a protective role in ethanol associated liver injury. Molecular Metabolism. 6: 1395-1406. PMID 29107287 DOI: 10.1016/J.Molmet.2017.08.004  0.234
2000 Pratic� D, Clark CM, Lee VM, Trojanowski JQ, Rokach J, FitzGerald GA. Increased 8,12-iso-iPF2?-VI in Alzheimer's disease: Correlation of a noninvasive index of lipid peroxidation with disease severity Annals of Neurology. 48: 809-812. DOI: 10.1002/1531-8249(200011)48:5<809::Aid-Ana19>3.0.Co;2-9  0.234
1983 Watson ML, Goodman RP, Gill JR, Tsunodo S, Branch RA, Fitzgerald GA, Brash AR. Systemic PGI2 Synthesis in Man is Decreased during Activation of the Renin-Angiotensin System Clinical Science. 64: 36P-36P. DOI: 10.1042/Cs064036Pa  0.233
2003 Charman WN, Charman SA, Monkhouse DC, Frisbee SE, Lockhart EA, Weisman S, Fitzgerald GA. Biopharmaceutical characterisation of a low-dose (75 mg) controlled-release aspirin formulation. British Journal of Clinical Pharmacology. 36: 470-3. PMID 12959298 DOI: 10.1111/J.1365-2125.1993.Tb00399.X  0.233
2018 Grosser T, Naji A, FitzGerald GA. Urinary Prostaglandin Metabolites: An Incomplete Reckoning and a Flush to Judgment. Circulation Research. 122: 537-539. PMID 29449357 DOI: 10.1161/Circresaha.118.312616  0.232
1987 Haywood JL, Fitzgerald GA, Cotton RB. Systemic Production Of Vasodilator Eicosanoids Is Not Increased In Infants With Symptomatic Patent Ductus Arteriosus (Spda) Who Fail Indomethacin Prophylaxis Pediatric Research. 21: 236-236. DOI: 10.1203/00006450-198704010-00413  0.232
2001 FitzGerald GA, Loll P. COX in a crystal ball: current status and future promise of prostaglandin research. The Journal of Clinical Investigation. 107: 1335-7. PMID 11390412 DOI: 10.1172/Jci13037  0.232
2001 Al-Abed Y, VanPatten S, Li H, Lawson JA, FitzGerald GA, Manogue KR, Bucala R. Characterization of a novel hemoglobin-glutathione adduct that is elevated in diabetic patients. Molecular Medicine (Cambridge, Mass.). 7: 619-23. PMID 11778651 DOI: 10.1007/Bf03401868  0.231
2013 Ricciotti E, Yu Y, Grosser T, Fitzgerald GA. COX-2, the dominant source of prostacyclin. Proceedings of the National Academy of Sciences of the United States of America. 110: E183. PMID 23292931 DOI: 10.1073/Pnas.1219073110  0.231
2012 Lowell AN, Qiao H, Liu T, Ishikawa T, Zhang H, Oriana S, Wang M, Ricciotti E, FitzGerald GA, Zhou R, Yamakoshi Y. Functionalized low-density lipoprotein nanoparticles for in vivo enhancement of atherosclerosis on magnetic resonance images. Bioconjugate Chemistry. 23: 2313-9. PMID 23075169 DOI: 10.1021/Bc300561E  0.23
2012 FitzGerald GA. Medicine. Can intellectual property save drug development? Science (New York, N.Y.). 338: 483-4. PMID 23112323 DOI: 10.1126/Science.1231170  0.23
1993 Sorensen JD, Olsen SF, Pedersen AK, Boris J, Secher NJ, FitzGerald GA. Effects of fish oil supplementation in the third trimester of pregnancy on prostacyclin and thromboxane production American Journal of Obstetrics and Gynecology. 168: 915-922. PMID 8456902 DOI: 10.1016/0020-7292(93)90339-X  0.229
2011 Meagher EA, Fitzgerald GA. Efficient drug approval and monitoring must rely on sound regulatory science. Nature Medicine. 17: 1535. PMID 22146443 DOI: 10.1038/Nm1211-1535  0.229
2000 Pratico D, Clark CC, Lee VM, Trojanowski JQ, FitzGerald GA. Increased isoprostane biosynthesis in alzheimer's disease: Correlation of a specific non invasive index of lipid peroxidation with disease severity Neurobiology of Aging. 21: 220. DOI: 10.1016/S0197-4580(00)83319-9  0.229
1979 Hossmann V, FitzGerald GA, Dollery CT. The Influence of Hospitalization and Placebo Therapy on Sympathetic Activity and Blood Pressure in Essential Hypertensive Patients Clinical Science. 57: 3P-4P. DOI: 10.1042/Cs057003Pc  0.228
2000 FitzGerald GA, Austin S, Egan K, Cheng Y, Pratico D. Cyclo-oxygenase products and atherothrombosis. Annals of Medicine. 32: 21-6. PMID 11209977  0.228
1998 Adiyaman M, Lawson JA, FitzGerald GA, Rokach J. Syntheses and identification of the most abundant urinary type VI isoprostanes Tetrahedron Letters. 39: 7039-7042. DOI: 10.1016/S0040-4039(98)01524-X  0.228
2018 Friedman ES, Bittinger K, Esipova TV, Hou L, Chau L, Jiang J, Mesaros C, Lund PJ, Liang X, FitzGerald GA, Goulian M, Lee D, Garcia BA, Blair IA, Vinogradov SA, et al. Microbes vs. chemistry in the origin of the anaerobic gut lumen. Proceedings of the National Academy of Sciences of the United States of America. PMID 29610310 DOI: 10.1073/Pnas.1718635115  0.227
2005 Kim S, Powell WS, Lawson JA, Jacobo SH, Pratico D, FitzGerald GA, Maxey K, Rokach J. iPF2alpha-III-17,18,19,20-d4: total synthesis and metabolism. Bioorganic & Medicinal Chemistry Letters. 15: 1613-7. PMID 15745808 DOI: 10.1016/J.Bmcl.2005.01.062  0.227
1979 Fitzgerald G, Petrie A. ANALYSIS OF EFFICACY OF ANTIHYPERTENSIVE DRUGS The Lancet. 313: 874. PMID 86117 DOI: 10.1016/S0140-6736(79)91286-8  0.226
1998 Praticò D, MY Lee V, Trojanowski JQ, Rokach J, Fitzgerald GA. Increased F2-isoprostanes in Alzheimer's disease: evidence for enhanced lipid peroxidation in vivo. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 12: 1777-83. PMID 9837868 DOI: 10.1096/Fasebj.12.15.1777  0.226
2007 Fitzgerald GA. Clinical pharmacology or translational medicine and therapeutics: reinvent or rebrand and expand? Clinical Pharmacology and Therapeutics. 81: 19-20. PMID 17185991 DOI: 10.1038/Sj.Clpt.6100044  0.226
2013 Yang G, Paschos G, Curtis AM, Musiek ES, McLoughlin SC, FitzGerald GA. Knitting up the raveled sleave of care. Science Translational Medicine. 5: 212rv3. PMID 24259052 DOI: 10.1126/Scitranslmed.3007225  0.225
1989 Goodnight SH, Fisher M, FitzGerald GA, Levine PH. Assessment of the therapeutic use of dietary fish oil in atherosclerotic vascular disease and thrombosis. Chest. 95: 19S-25S. PMID 2644100 DOI: 10.1378/Chest.95.2_Supplement.19S  0.225
2020 Song WC, FitzGerald GA. COVID-19, microangiopathy, hemostatic activation, and complement. The Journal of Clinical Investigation. PMID 32459663 DOI: 10.1172/Jci140183  0.225
2010 Piano MR, Benowitz NL, Fitzgerald GA, Corbridge S, Heath J, Hahn E, Pechacek TF, Howard G. Impact of smokeless tobacco products on cardiovascular disease: implications for policy, prevention, and treatment: a policy statement from the American Heart Association. Circulation. 122: 1520-44. PMID 20837898 DOI: 10.1161/Cir.0B013E3181F432C3  0.225
2014 Liang X, Bushman FD, FitzGerald GA. Time in motion: the molecular clock meets the microbiome. Cell. 159: 469-70. PMID 25417097 DOI: 10.1016/J.Cell.2014.10.020  0.225
2012 Bubela T, FitzGerald GA, Gold ER. Recalibrating intellectual property rights to enhance translational research collaborations. Science Translational Medicine. 4: 122cm3. PMID 22357536 DOI: 10.1126/Scitranslmed.3003490  0.225
2006 Jacobo SH, Chang CT, Lee GJ, Lawson JA, Powell WS, Pratico D, FitzGerald GA, Rokach J. Total synthesis of 8,12-iso-iPF3alpha-VI, an EPA-derived isoprostane: stereoselective introduction of the fifth asymmetric center. The Journal of Organic Chemistry. 71: 1370-9. PMID 16468784 DOI: 10.1021/Jo051916X  0.224
2004 Ky B, Wolfe ML, Burke A, Szapary PO, Reilly MP, Dykhouse JB, Bloedon LT, FitzGerald GA, Rader DJ. 1008-184 The effects of pravastatin and atorvastatin on markers of oxidant stress in vivo Journal of the American College of Cardiology. 43: A446. DOI: 10.1016/S0735-1097(04)91877-3  0.222
1999 Namara PM, Lawson JA, Rokach J, FitzGerald GA. F2 and E2 isoprostanes are ligands for peroxisome proliferator-activated receptors α and γ Prostaglandins & Other Lipid Mediators. 59: 96. DOI: 10.1016/S0090-6980(99)90331-3  0.222
2020 Hegyi P, Petersen OH, Holgate S, Erőss B, Garami A, Szakács Z, Dobszai D, Balaskó M, Kemény L, Peng S, Monteiro J, Varró A, Lamont T, Laurence J, Gray Z, ... ... FitzGerald GA, et al. Academia Europaea Position Paper on Translational Medicine: The Cycle Model for Translating Scientific Results into Community Benefits. Journal of Clinical Medicine. 9. PMID 32438747 DOI: 10.3390/Jcm9051532  0.222
2015 FitzGerald GA. Evolution in translational science: Whither the CTSAs? Science Translational Medicine. 7: 284fs15. PMID 25904737 DOI: 10.1126/Scitranslmed.Aab1596  0.222
2002 Kim S, Lawson JA, Praticò D, FitzGerald GA, Rokach J. The first total synthesis of iPF4α-VI and its deuterated analog Tetrahedron Letters. 43: 2801-2805. DOI: 10.1016/S0040-4039(02)00398-2  0.221
1996 Adiyaman M, Lawson JA, Hwang SW, Khanapure SP, FitzGerald GA, Rokach J. Total synthesis of a novel isoprostane IPF(2α)-I and its identification in biological fluids Tetrahedron Letters. 37: 4849-4852. DOI: 10.1016/0040-4039(96)00973-2  0.221
1995 Pratico D, FitzGerald GA. Testosterone and thromboxane. Of muscles, mice, and men. Circulation. 91: 2694-8. PMID 7758172 DOI: 10.1161/01.Cir.91.11.2694  0.22
2010 FitzGerald GA, Travis K. Science Translational Medicine Podcast: 7 April 2010 Science Translational Medicine. 2: 26pc2-26pc2. DOI: 10.1126/Scitranslmed.26Pc2  0.219
2013 FitzGerald GA. Anecdotes from ITMAT: building capacity for translational science. Clinical Pharmacology and Therapeutics. 94: 291-6. PMID 23963214 DOI: 10.1038/Clpt.2013.84  0.219
1986 Kuehl PG, Cotton RB, FitzGerald GA. Systemic production of prostacyclin and thromboxane A2 does not correlate with patency of the ductus arteriosus in very low birth weight infants. The Journal of Pediatrics. 108: 977-82. PMID 3519915 DOI: 10.1016/S0022-3476(86)80943-X  0.218
2010 Huckabee M, Zhou W, Newcomb D, Goleniewska K, FitzGerald G, Peebles R. Signaling through the PGI2 Receptor Promotes IL-17 Production by CD4 T Cells Journal of Allergy and Clinical Immunology. 125: AB143. DOI: 10.1016/J.Jaci.2009.12.562  0.218
1991 Cotton RB, Haywood JL, FitzGerald GA. Symptomatic patent ductus arteriosus following prophylactic indomethacin. A clinical and biochemical appraisal. Biology of the Neonate. 60: 273-82. PMID 1790251 DOI: 10.1159/000243418  0.218
2010 Reis SE, Berglund L, Bernard GR, Califf RM, Fitzgerald GA, Johnson PC. Reengineering the national clinical and translational research enterprise: the strategic plan of the National Clinical and Translational Science Awards Consortium. Academic Medicine : Journal of the Association of American Medical Colleges. 85: 463-9. PMID 20182119 DOI: 10.1097/Acm.0B013E3181Ccc877  0.217
2008 Fitzgerald GA. Drugs, industry, and academia. Science (New York, N.Y.). 320: 1563. PMID 18566251 DOI: 10.1126/Science.1161006  0.217
1999 Saha G, Basu MK, Kim S, Jung Y, Adiyaman Y, Adiyaman M, Powell WS, FitzGerald GA, Rokach J. A convenient strategy for the synthesis of β,γ-unsaturated aldehydes and acids. A construction of skipped dienes Tetrahedron Letters. 40: 7179-7183. DOI: 10.1016/S0040-4039(99)01498-7  0.215
2020 FitzGerald GA. Misguided drug advice for COVID-19. Science (New York, N.Y.). 367: 1434. PMID 32198292 DOI: 10.1126/Science.Abb8034  0.214
1980 Barnes P, FitzGerald G, Brown M, Dollery C. Nocturnal asthma and changes in circulating epinephrine, histamine, and cortisol. The New England Journal of Medicine. 303: 263-7. PMID 6247655 DOI: 10.1056/Nejm198007313030506  0.214
2009 Maree AO, Fitzgerald GA. A roadmap for the twilight zone: navigating United States cardiovascular career development for international trainees. Circulation. 120: 1542-9. PMID 19822817 DOI: 10.1161/Circulationaha.108.811646  0.213
2010 Fitzgerald G. Drug development needs a new brand of science Nature. 468: 869. PMID 21164436 DOI: 10.1038/468869A  0.213
2015 Liang X, Bittinger K, Li X, Abernethy DR, Bushman FD, FitzGerald GA. Author response: Bidirectional interactions between indomethacin and the murine intestinal microbiota Elife. DOI: 10.7554/Elife.08973.023  0.211
1980 Barnes P, Dollery CT, Fitzgerald GA, Hamilton CA. The kinetics and concentration-effect relationships of circulating adrenaline in man [proceedings]. British Journal of Clinical Pharmacology. 9: 107P-108P. PMID 7356872 DOI: 10.1111/J.1365-2125.1980.Tb04809.X  0.21
2002 Burke A, FitzGerald GA, Lucey MR. A prospective analysis of oxidative stress and liver transplantation. Transplantation. 74: 217-21. PMID 12151734 DOI: 10.1097/00007890-200207270-00012  0.21
2020 Lordan R, FitzGerald GA, Grosser T. Reopening schools during COVID-19. Science (New York, N.Y.). 369: 1146. PMID 32883837 DOI: 10.1126/Science.Abe5765  0.21
1999 Burke A, Lucey MR, Meagher EA, FitzGerald GA. IPF2α-III-M: A NOVEL MARKER OF OXIDANT STRESS IN ORTHOTOPIC LIVER TRANSPLANT (OLT) PATIENTS. Transplantation. 67: S260. DOI: 10.1097/00007890-199904150-01037  0.209
2005 Egan KM, Wang M, Fries S, Lucitt MB, Zukas AM, Puré E, Lawson JA, FitzGerald GA. Cyclooxygenases, thromboxane, and atherosclerosis: plaque destabilization by cyclooxygenase-2 inhibition combined with thromboxane receptor antagonism. Circulation. 111: 334-42. PMID 15655126 DOI: 10.1161/01.CIR.0000153386.95356.78  0.209
1998 FitzGerald GA, Charman WN. Interpretation of Thrombosis Prevention Trial. Lancet. 351: 1206-7. PMID 9643718 DOI: 10.1016/S0140-6736(05)79155-8  0.208
1982 FitzGerald GA, Brash AR. ENDOGENOUS PROSTACYCLIN AND THROMBOXANE BIOSYNTHESIS DURING CHRONIC VITAMIN E THERAPY IN MAN Annals of the New York Academy of Sciences. 393: 209-211. DOI: 10.1111/J.1749-6632.1982.Tb31256.X  0.206
1999 Adiyaman M, Jung Y, Kim S, Saha G, Powell WS, FitzGerald GA, Rokach J. A new method for the preparation of olefins from vicinal diols Tetrahedron Letters. 40: 4019-4022. DOI: 10.1016/S0040-4039(99)00675-9  0.206
2016 Baruzzo G, Hayer KE, Kim EJ, Di Camillo B, FitzGerald GA, Grant GR. Simulation-based comprehensive benchmarking of RNA-seq aligners. Nature Methods. PMID 27941783 DOI: 10.1038/Nmeth.4106  0.205
2017 Friedman ES, Esipova TV, Bittinger K, Hou L, Chau L, Jiang J, Mesaros C, Lund P, Liang X, FitzGerald G, Lee D, Blair IA, Garcia B, Vinogradov S, Wu GD. Origins of the Anaerobic Gut Lumen: Microbes vs. Chemistry Gastroenterology. 152: S33. DOI: 10.1016/S0016-5085(17)30474-2  0.205
2018 FitzGerald G, Botstein D, Califf R, Collins R, Peters K, Van Bruggen N, Rader D. The future of humans as model organisms. Science (New York, N.Y.). 361: 552-553. PMID 30093589 DOI: 10.1126/Science.Aau7779  0.205
1999 Hwang SW, Adiyaman M, Lawson JA, FitzGerald GA, Rokach J. Synthesis of iPF(2α)-V: A new route Tetrahedron Letters. 40: 6167-6170. DOI: 10.1016/S0040-4039(99)01144-2  0.205
2016 FitzGerald GA. Measure for Measure: Biomarker standards and transparency. Science Translational Medicine. 8: 343fs10. PMID 27306662 DOI: 10.1126/Scitranslmed.Aaf8590  0.203
2011 Dowell D, Zhou W, Huckabee M, Newcomb D, Goleniewska K, Fitzgerald G, Peebles Jr. R. Prostaglandin I2 Signaling Exacerbates Experimental Autoimmune Encephalomyelitis Journal of Allergy and Clinical Immunology. 127: AB232-AB232. DOI: 10.1016/J.Jaci.2010.12.925  0.202
2005 Chang CT, Jacobo SH, Powell WS, Lawson JA, FitzGerald GA, Pratico D, Rokach J. A new synthetic approach for 4(S)-hydroxycyclopent-2-enone: A precursor to prostanoid synthesis Tetrahedron Letters. 46: 6325-6328. DOI: 10.1016/J.Tetlet.2005.07.035  0.202
2002 Lawson JA, FitzGerald GA. Analysis of isoprostanes European Journal of Lipid Science and Technology. 104: 429-435. DOI: 10.1002/1438-9312(200207)104:7<429::Aid-Ejlt429>3.0.Co;2-O  0.201
2012 FitzGerald GA. "What great creation". Interview by Alisa M. Clyne. Science Translational Medicine. 4: 154cm10. PMID 23035043 DOI: 10.1126/Scitranslmed.3004480  0.2
2019 Edelman ER, FitzGerald GA. A decade of . Science Translational Medicine. 11. PMID 31019024 DOI: 10.1126/Scitranslmed.Aax4327  0.2
2009 FitzGerald GA. Moving clinical research in academic medical centres up the value chain Nature Reviews Drug Discovery. 8: 597. DOI: 10.1038/Nrd2954  0.196
2011 FitzGerald GA. NCATS purrs: emerging signs of form and function. Science Translational Medicine. 3: 83ed2. PMID 21593398 DOI: 10.1126/Scitranslmed.3002232  0.195
2011 Edelman ER, FitzGerald GA. A rattle bag of science and the art of translation. Science Translational Medicine. 3: 104ed3. PMID 21998406 DOI: 10.1126/Scitranslmed.3002131  0.195
1994 Kinsella BT, O'Mahony D, Lawson JA, Pratico D, Fitzgerald GA. Cellular activation of thromboxane receptors. Annals of the New York Academy of Sciences. 714: 270-8. PMID 8017778 DOI: 10.1111/j.1749-6632.1994.tb12054.x  0.193
2017 Grosser T, Woolf CJ, FitzGerald GA. Time for nonaddictive relief of pain. Science (New York, N.Y.). 355: 1026-1027. PMID 28280170 DOI: 10.1126/Science.Aan0088  0.193
2001 FitzGerald GA. Vitamin E Supplementation in Healthy Persons—Reply Jama. 285: 2449. DOI: 10.1001/Jama.285.19.2449  0.192
1987 Reilly I, FitzGerald G. Inhibition of thromboxane formation in vivo and ex vivo: implications for therapy with platelet inhibitory drugs Blood. 69: 180-186. DOI: 10.1182/BLOOD.V69.1.180.BLOODJOURNAL691180  0.191
1987 Reilly I, FitzGerald G. Inhibition of thromboxane formation in vivo and ex vivo: implications for therapy with platelet inhibitory drugs Blood. 69: 180-186. DOI: 10.1182/blood.v69.1.180.180  0.191
2005 Westgate EJ, Fitzgerald GA. Pulmonary embolism in a woman taking oral contraceptives and valdecoxib. Plos Medicine. 2: e197. PMID 16013893 DOI: 10.1371/Journal.Pmed.0020197  0.19
1997 Barry OP, Pratico D, Lawson JA, FitzGerald GA. Transcellular activation of platelets and endothelial cells by bioactive lipids in platelet microparticles. The Journal of Clinical Investigation. 99: 2118-27. PMID 9151784 DOI: 10.1172/JCI119385  0.19
1999 Reilly M, Tigges J, Loh E, Lawson J, FitzGerald G. Isoprostane generation in chronic heart failure Prostaglandins & Other Lipid Mediators. 59: 183. DOI: 10.1016/S0090-6980(99)90418-5  0.189
2004 Hennekens CH, Schror K, Weisman S, FitzGerald GA. Terms and conditions: semantic complexity and aspirin resistance. Circulation. 110: 1706-8. PMID 15381661 DOI: 10.1161/01.Cir.0000142056.69970.Db  0.188
1999 Catella-Lawson F, McAdam B, Morrison BW, Kapoor S, Kujubu D, Antes L, Lasseter KC, Quan H, Gertz BJ, FitzGerald GA. Effects of specific inhibition of cyclooxygenase-2 on sodium balance, hemodynamics, and vasoactive eicosanoids. The Journal of Pharmacology and Experimental Therapeutics. 289: 735-41. PMID 10215647  0.187
1988 Dworski R, Wendelborn DF, Sheller JR, FitzGerald GA, Roberts LJ. Prostaglandins in Ascaris antigen. The Journal of Allergy and Clinical Immunology. 82: 484. PMID 3170997 DOI: 10.1016/0091-6749(88)90025-5  0.187
2020 Anderson ST, FitzGerald GA. Sexual dimorphism in body clocks. Science (New York, N.Y.). 369: 1164-1165. PMID 32883849 DOI: 10.1126/Science.Abd4964  0.187
2012 FitzGerald GA. The obscure targets of desire Nature Medicine. 18: 343-343. DOI: 10.1038/Nm.2696  0.183
1997 Juliano L, Praticò D, Mauriello A, Spagnoli L, Lawson J, Maclouf J, FitzGerald G, Violi F. OP-22. Localization of isoprostane, 8-epi PGF24aL, in atherosclerotic lesions Nuclear Medicine Communications. 18: 472. DOI: 10.1097/00006231-199705000-00053  0.182
2015 Iyengar R, Altman RB, Troyanskya O, FitzGerald GA. MEDICINE. Personalization in practice. Science (New York, N.Y.). 350: 282-3. PMID 26472898 DOI: 10.1126/Science.Aad5204  0.181
2015 Cappola AR, FitzGerald GA. Confluence, Not Conflict of Interest: Name Change Necessary. Jama. 314: 1791-2. PMID 26402846 DOI: 10.1001/Jama.2015.12020  0.179
2016 Cappola AR, FitzGerald GA. Conflict or Confluence of Interest?--Reply. Jama. 315: 1793-4. PMID 27115391 DOI: 10.1001/Jama.2016.0327  0.172
1997 Kunapuli P, Lawson JA, Rokach J, FitzGerald GA. Functional characterization of the ocular prostaglandin f2alpha (PGF2alpha) receptor. Activation by the isoprostane, 12-iso-PGF2alpha. The Journal of Biological Chemistry. 272: 27147-54. PMID 9341156 DOI: 10.1074/Jbc.272.43.27147  0.171
2001 Narumiya S, FitzGerald GA. Genetic and pharmacological analysis of prostanoid receptor function. The Journal of Clinical Investigation. 108: 25-30. PMID 11435452 DOI: 10.1172/JCI13455  0.17
1997 FitzGerald GA, Barry P. Dietary factors in thrombosis and hemostasis: summary and conclusions. The American Journal of Clinical Nutrition. 65: 1699S-1701S. PMID 9129512  0.169
2022 Brown TJ, Barrett NA, Meng H, Ricciotti E, McDonnell CM, Dancis A, Qualtieri JN, FitzGerald GA, Cotter M, Babushok DV. Non-steroidal anti-inflammatory drugs as a targeted therapy for bone marrow failure in Ghosal Hematodiaphyseal Dysplasia. Blood. PMID 36574346 DOI: 10.1182/blood.2022018667  0.168
2023 Rodriguez LR, Tang SY, Roque Barboza W, Murthy A, Tomer Y, Cai TQ, Iyer S, Chavez K, Das US, Ghosh S, Cooper C, Dimopoulos TT, Babu A, Connelly CF, FitzGerald GA, et al. PGF2α signaling drives fibrotic remodeling and fibroblast population dynamics in mice. Jci Insight. PMID 37934604 DOI: 10.1172/jci.insight.172977  0.164
1994 Kinsella BT, O'Mahony DJ, FitzGerald GA. Phosphorylation and regulated expression of the human thromboxane A2 receptor. The Journal of Biological Chemistry. 269: 29914-9. PMID 7961988  0.163
2023 Rodriguez LR, Tang SY, Barboza WR, Murthy A, Tomer Y, Cai TQ, Iyer S, Chavez K, Das US, Ghosh S, Dimopoulos T, Babu A, Connelly C, FitzGerald GA, Beers MF. Disruption of Prostaglandin F Receptor Signaling Attenuates Fibrotic Remodeling and Alters Fibroblast Population Dynamics in A Preclinical Murine Model of Idiopathic Pulmonary Fibrosis. Biorxiv : the Preprint Server For Biology. PMID 37333249 DOI: 10.1101/2023.06.07.543956  0.161
2001 FitzGerald GA, Cheng Y, Austin S. COX-2 inhibitors and the cardiovascular system. Clinical and Experimental Rheumatology. 19: S31-6. PMID 11695249  0.161
2022 Schebb NH, Kühn H, Kahnt AS, Rund KM, O'Donnell VB, Flamand N, Peters-Golden M, Jakobsson PJ, Weylandt KH, Rohwer N, Murphy RC, Geisslinger G, FitzGerald GA, Hanson J, Dahlgren C, et al. Formation, Signaling and Occurrence of Specialized Pro-Resolving Lipid Mediators-What is the Evidence so far? Frontiers in Pharmacology. 13: 838782. PMID 35308198 DOI: 10.3389/fphar.2022.838782  0.16
2023 Kim B, Zhao W, Tang SY, Levin MG, Ibrahim A, Yang Y, Roberts EM, Lai L, Li J, Assoian RK, FitzGerald GA, Arany Z. Endothelial lipid droplets suppress eNOS to link high fat consumption to blood pressure elevation. The Journal of Clinical Investigation. PMID 37824206 DOI: 10.1172/JCI173160  0.154
1986 Pedersen AK, FitzGerald GA. The human pharmacology of platelet inhibition: pharmacokinetics relevant to drug action. Circulation. 72: 1164-76. PMID 3905047 DOI: 10.1161/01.CIR.72.6.1164  0.152
2024 Ricciotti E, Haines PG, Chai W, FitzGerald GA. Prostanoids in Cardiac and Vascular Remodeling. Arteriosclerosis, Thrombosis, and Vascular Biology. PMID 38269585 DOI: 10.1161/ATVBAHA.123.320045  0.151
2021 Mazaleuskaya LL, Lee S, Meng H, Winkler JD, FitzGerald GA. Targeted Delivery of mPGES-1 Inhibitors to Macrophages via the Folate Receptor-β for Inflammatory Pain. Bioorganic & Medicinal Chemistry Letters. 128313. PMID 34390827 DOI: 10.1016/j.bmcl.2021.128313  0.149
1997 Praticò D, Reilly M, Lawson JA, FitzGerald GA. Novel indices of oxidant stress in cardiovascular disease: specific analysis of F2-isoprostanes. Agents and Actions. Supplements. 48: 25-41. PMID 9177098  0.147
1998 Kunapuli P, Lawson JA, Rokach JA, Meinkoth JL, FitzGerald GA. Prostaglandin F2alpha (PGF2alpha) and the isoprostane, 8, 12-iso-isoprostane F2alpha-III, induce cardiomyocyte hypertrophy. Differential activation of downstream signaling pathways. The Journal of Biological Chemistry. 273: 22442-52. PMID 9712868 DOI: 10.1074/jbc.273.35.22442  0.146
2021 Tang SY, Meng H, Anderson ST, Sarantopoulou D, Ghosh S, Lahens NF, Theken KN, Ricciotti E, Hennessy EJ, Tu V, Bittinger K, Weljie AM, Grant GR, FitzGerald GA. Sex-dependent compensatory mechanisms preserve blood pressure homeostasis in prostacyclin receptor deficient mice. The Journal of Clinical Investigation. PMID 34101620 DOI: 10.1172/JCI136310  0.145
2006 Crofford LJ, Breyer MD, Strand CV, Rushitzka F, Brune K, Farkouh ME, Simon LS, FitzGerald GA, Patrono C. Cardiovascular effects of selective COX-2 inhibition: Is there a class effect? The international COX-2 study group Journal of Rheumatology. 33: 1403-1408. PMID 16724374  0.144
1997 Praticò D, Iuliano L, Mauriello A, Spagnoli L, Lawson JA, Rokach J, Maclouf J, Violi F, FitzGerald GA. Localization of distinct F2-isoprostanes in human atherosclerotic lesions. The Journal of Clinical Investigation. 100: 2028-34. PMID 9329967 DOI: 10.1172/JCI119735  0.144
1994 Fitzgerald GA, Meagher EA. Antiplatelet drugs. European Journal of Clinical Investigation. 46-9. PMID 7516881 DOI: 10.1111/j.1365-2362.1994.tb02427.x  0.144
1987 Nowak J, Wennmalm M, Edlund A, Wennmalm A, Fitzgerald GA. Vascular effects of infused adenosine are not mediated by prostacyclin release in humans. The American Journal of Physiology. 252: H598-604. PMID 3548440 DOI: 10.1152/ajpheart.1987.252.3.H598  0.142
1995 Pratico D, Reilly M, Lawson J, Delanty N, FitzGerald GA. Formation of 8-iso-prostaglandin F2 alpha by human platelets. Agents and Actions. Supplements. 45: 27-31. PMID 7717189  0.142
1991 Murray JJ, Nowak J, Oates JA, FitzGerald GA. Platelet-vessel wall interactions in individuals who smoke cigarettes. Advances in Experimental Medicine and Biology. 273: 189-98. PMID 2288276 DOI: 10.1007/978-1-4684-5829-9_19  0.141
2019 Chen L, Yang G, Jiang T, Tang SY, Wang T, Wan Q, Wang M, FitzGerald GA. Myeloid cell mPges-1 depletion attenuates mortality without affecting remodeling after acute myocardial infarction in mice. The Journal of Pharmacology and Experimental Therapeutics. PMID 30992314 DOI: 10.1124/jpet.118.256057  0.141
2024 Lin YC, Swendeman S, Moreira IS, Ghosh A, Kuo A, Rosário-Ferreira N, Guo S, Culbertson A, Levesque MV, Cartier A, Seno T, Schmaier A, Galvani S, Inoue A, Parikh SM, ... FitzGerald GA, et al. Designer high-density lipoprotein particles enhance endothelial barrier function and suppress inflammation. Science Signaling. 17: eadg9256. PMID 38377179 DOI: 10.1126/scisignal.adg9256  0.141
2001 Cyrus T, Tang LX, Rokach J, FitzGerald GA, Praticò D. Lipid peroxidation and platelet activation in murine atherosclerosis. Circulation. 104: 1940-5. PMID 11602498 DOI: 10.1161/Hc4101.097114  0.139
2001 Mardini IA, FitzGerald GA. Selective inhibitors of cyclooxygenase-2: a growing class of anti-inflammatory drugs. Molecular Interventions. 1: 30-8. PMID 14993336  0.139
2023 Wu J, Jing X, Du Q, Sun X, Holgersson K, Gao J, He X, Hosaka K, Zhao C, Tao W, FitzGerald GA, Yang Y, Jensen LD, Cao Y. Disruption of the Clock Component Bmal1 in Mice Promotes Cancer Metastasis through the PAI-1-TGF-β-myoCAF-Dependent Mechanism. Advanced Science (Weinheim, Baden-Wurttemberg, Germany). e2301505. PMID 37330661 DOI: 10.1002/advs.202301505  0.135
2022 Spence JD, Grosser T, FitzGerald GA. Acetaminophen, Nonsteroidal Anti-Inflammatory Drugs, and Hypertension. Hypertension (Dallas, Tex. : 1979). 79: 1922-1926. PMID 35862146 DOI: 10.1161/HYPERTENSIONAHA.122.19315  0.132
2001 Patrono C, Coller B, Dalen JE, FitzGerald GA, Fuster V, Gent M, Hirsh J, Roth G. Platelet-active drugs : the relationships among dose, effectiveness, and side effects. Chest. 119: 39S-63S. PMID 11157642  0.13
1987 Nowak J, Murray JJ, Oates JA, FitzGerald GA. Biochemical evidence of a chronic abnormality in platelet and vascular function in healthy individuals who smoke cigarettes. Circulation. 76: 6-14. PMID 3297389 DOI: 10.1161/01.CIR.76.1.6  0.129
1989 Reilly IA, Knapp HR, Fitzgerald GA. Leukotriene B4 synthesis and neutrophil chemotaxis in chronic granulocytic leukaemia. Journal of Clinical Pathology. 41: 1163-7. PMID 2850300 DOI: 10.1136/jcp.41.11.1163  0.128
2000 Burke A, Lawson JA, Meagher EA, Rokach J, FitzGerald GA. Specific analysis in plasma and urine of 2,3-dinor-5, 6-dihydro-isoprostane F(2alpha)-III, a metabolite of isoprostane F(2alpha)-III and an oxidation product of gamma-linolenic acid. The Journal of Biological Chemistry. 275: 2499-504. PMID 10644705 DOI: 10.1074/Jbc.275.4.2499  0.127
1999 Rocca B, Spain LM, Ciabattoni G, Patrono C, FitzGerald GA. Differential expression and regulation of cyclooxygenase isozymes in thymic stromal cells. Journal of Immunology (Baltimore, Md. : 1950). 162: 4589-97. PMID 10201998  0.127
2024 El Jamal N, Brooks TG, Cohen J, Townsend RR, Sosa GR, Shah V, Nelson RG, Drawz PE, Rao P, Bhat Z, Chang A, Yang W, FitzGerald GA, Skarke C. Prognostic utility of rhythmic components in 24-h ambulatory blood pressure monitoring for the risk stratification of chronic kidney disease patients with cardiovascular co-morbidity. Journal of Human Hypertension. PMID 38212425 DOI: 10.1038/s41371-023-00884-0  0.124
2006 FitzGerald G. Tu-ML5:1 Cardiovascular consequences of cyclooxygenase inhibition; pharmacological targets beyond COX-2 Atherosclerosis Supplements. 7: 151. DOI: 10.1016/S1567-5688(06)80596-9  0.123
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