Alexander F. Hoffman, Ph.D. - Publications

Affiliations: 
NIDA Intramural Research Program 
Area:
cannabinoids, cocaine, electrophysiology, addiction

50/75 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2019 Lecca D, Bader M, Tweedie D, Hoffman AF, Jung YJ, Hsueh SC, Hoffer BJ, Becker RE, Pick CG, Lupica CR, Greig NH. (-)-Phenserine and the prevention of pre-programmed cell death and neuroinflammation in mild traumatic brain injury and Alzheimer's disease challenged mice. Neurobiology of Disease. 104528. PMID 31295555 DOI: 10.1016/j.nbd.2019.104528  1
2019 Bäck S, Necarsulmer J, Whitaker LR, Coke LM, Koivula P, Heathward EJ, Fortuno LV, Zhang Y, Yeh CG, Baldwin HA, Spencer MD, Mejias-Aponte CA, Pickel J, Hoffman AF, Spivak CE, et al. Neuron-Specific Genome Modification in the Adult Rat Brain Using CRISPR-Cas9 Transgenic Rats. Neuron. PMID 30792150 DOI: 10.1016/j.neuron.2019.01.035  1
2019 Bonifazi A, Yano H, Guerrero AM, Kumar V, Hoffman AF, Lupica CR, Shi L, Newman AH. Novel and Potent Dopamine D Receptor Go-Protein Biased Agonists. Acs Pharmacology & Translational Science. 2: 52-65. PMID 30775693 DOI: 10.1021/acsptsci.8b00060  1
2018 Lupica CR, Hoffman AF. Cannabinoid disruption of learning mechanisms involved in reward processing. Learning & Memory (Cold Spring Harbor, N.Y.). 25: 435-445. PMID 30115765 DOI: 10.1101/lm.046748.117  1
2018 Michaelides M, Miller ML, Egervari G, Primeaux SD, Gomez JL, Ellis RJ, Landry JA, Szutorisz H, Hoffman AF, Lupica CR, Loos RJF, Thanos PK, Bray GA, Neumaier JF, Zachariou V, et al. Striatal Rgs4 regulates feeding and susceptibility to diet-induced obesity. Molecular Psychiatry. PMID 29955167 DOI: 10.1038/s41380-018-0120-7  1
2018 Yano H, Cai NS, Xu M, Verma RK, Rea W, Hoffman AF, Shi L, Javitch JA, Bonci A, Ferré S. Gs- versus Golf-dependent functional selectivity mediated by the dopamine D1 receptor. Nature Communications. 9: 486. PMID 29402888 DOI: 10.1038/s41467-017-02606-w  1
2017 Lupica CR, Hu Y, Devinsky O, Hoffman AF. Cannabinoids as hippocampal network administrators. Neuropharmacology. PMID 28392266 DOI: 10.1016/j.neuropharm.2017.04.003  1
2016 Wright AM, Zapata A, Baumann MH, Elmore JS, Hoffman AF, Lupica CR. Enduring Loss of Serotonergic Control of Orbitofrontal Cortex Function Following Contingent and Noncontingent Cocaine Exposure. Cerebral Cortex (New York, N.Y. : 1991). PMID 27733540 DOI: 10.1093/cercor/bhw312  1
2016 Hoffman AF, Spivak CE, Lupica CR. Enhanced Dopamine Release by Dopamine Transport Inhibitors Described by a Restricted Diffusion Model and Fast-Scan Cyclic Voltammetry. Acs Chemical Neuroscience. PMID 27018734 DOI: 10.1021/acschemneuro.5b00277  1
2016 Hoffman AF, Lycas MD, Kaczmarzyk JR, Spivak CE, Baumann MH, Lupica CR. Disruption of hippocampal synaptic transmission and long-term potentiation by psychoactive synthetic cannabinoid 'Spice' compounds: comparison with Δ(9) -tetrahydrocannabinol. Addiction Biology. PMID 26732435 DOI: 10.1111/adb.12334  1
2015 Root DH, Hoffman AF, Good CH, Zhang S, Gigante E, Lupica CR, Morales M. Norepinephrine activates dopamine D4 receptors in the rat lateral habenula. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 35: 3460-9. PMID 25716845 DOI: 10.1523/JNEUROSCI.4525-13.2015  1
2015 Zhang S, Qi J, Li X, Wang HL, Britt JP, Hoffman AF, Bonci A, Lupica CR, Morales M. Dopaminergic and glutamatergic microdomains in a subset of rodent mesoaccumbens axons. Nature Neuroscience. 18: 386-92. PMID 25664911 DOI: 10.1038/nn.3945  1
2014 Qi J, Zhang S, Wang HL, Wang H, de Jesus Aceves Buendia J, Hoffman AF, Lupica CR, Seal RP, Morales M. A glutamatergic reward input from the dorsal raphe to ventral tegmental area dopamine neurons. Nature Communications. 5: 5390. PMID 25388237 DOI: 10.1038/ncomms6390  1
2014 Root DH, Mejias-Aponte CA, Zhang S, Wang HL, Hoffman AF, Lupica CR, Morales M. Single rodent mesohabenular axons release glutamate and GABA. Nature Neuroscience. 17: 1543-51. PMID 25242304 DOI: 10.1038/nn.3823  1
2014 Lucantonio F, Takahashi YK, Hoffman AF, Chang CY, Bali-Chaudhary S, Shaham Y, Lupica CR, Schoenbaum G. Orbitofrontal activation restores insight lost after cocaine use. Nature Neuroscience. 17: 1092-9. PMID 25042581 DOI: 10.1038/nn.3763  1
2013 Good CH, Wang H, Chen YH, Mejias-Aponte CA, Hoffman AF, Lupica CR. Dopamine D4 receptor excitation of lateral habenula neurons via multiple cellular mechanisms. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 33: 16853-64. PMID 24155292 DOI: 10.1523/JNEUROSCI.1844-13.2013  1
2013 Jhou TC, Good CH, Rowley CS, Xu SP, Wang H, Burnham NW, Hoffman AF, Lupica CR, Ikemoto S. Cocaine drives aversive conditioning via delayed activation of dopamine-responsive habenular and midbrain pathways. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 33: 7501-12. PMID 23616555 DOI: 10.1523/JNEUROSCI.3634-12.2013  1
2013 Hoffman AF, Lupica CR. Synaptic targets of Δ9-tetrahydrocannabinol in the central nervous system. Cold Spring Harbor Perspectives in Medicine. 3. PMID 23209160 DOI: 10.1101/cshperspect.a012237  1
2013 Baumann MH, Partilla JS, Lehner KR, Thorndike EB, Hoffman AF, Holy M, Rothman RB, Goldberg SR, Lupica CR, Sitte HH, Brandt SD, Tella SR, Cozzi NV, Schindler CW. Powerful cocaine-like actions of 3,4-methylenedioxypyrovalerone (MDPV), a principal constituent of psychoactive 'bath salts' products. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 38: 552-62. PMID 23072836 DOI: 10.1038/npp.2012.204  1
2012 Koya E, Cruz FC, Ator R, Golden SA, Hoffman AF, Lupica CR, Hope BT. Silent synapses in selectively activated nucleus accumbens neurons following cocaine sensitization. Nature Neuroscience. 15: 1556-62. PMID 23023294 DOI: 10.1038/nn.3232  1
2012 Zhang Y, Granholm AC, Huh K, Shan L, Diaz-Ruiz O, Malik N, Olson L, Hoffer BJ, Lupica CR, Hoffman AF, Bäckman CM. PTEN deletion enhances survival, neurite outgrowth and function of dopamine neuron grafts to MitoPark mice. Brain : a Journal of Neurology. 135: 2736-49. PMID 22961549 DOI: 10.1093/brain/aws196  1
2012 Diaz-Ruiz O, Zhang Y, Shan L, Malik N, Hoffman AF, Ladenheim B, Cadet JL, Lupica CR, Tagliaferro A, Brusco A, Bäckman CM. Attenuated response to methamphetamine sensitization and deficits in motor learning and memory after selective deletion of β-catenin in dopamine neurons. Learning & Memory (Cold Spring Harbor, N.Y.). 19: 341-50. PMID 22822182 DOI: 10.1101/lm.026716.112  1
2012 Sterky FH, Hoffman AF, Milenkovic D, Bao B, Paganelli A, Edgar D, Wibom R, Lupica CR, Olson L, Larsson NG. Altered dopamine metabolism and increased vulnerability to MPTP in mice with partial deficiency of mitochondrial complex I in dopamine neurons. Human Molecular Genetics. 21: 1078-89. PMID 22090423 DOI: 10.1093/hmg/ddr537  1
2011 Good CH, Hoffman AF, Hoffer BJ, Chefer VI, Shippenberg TS, Bäckman CM, Larsson NG, Olson L, Gellhaar S, Galter D, Lupica CR. Impaired nigrostriatal function precedes behavioral deficits in a genetic mitochondrial model of Parkinson's disease. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 25: 1333-44. PMID 21233488 DOI: 10.1096/fj.10-173625  1
2010 Luo Y, Good CH, Diaz-Ruiz O, Zhang Y, Hoffman AF, Shan L, Kuang SY, Malik N, Chefer VI, Tomac AC, Lupica CR, Bäckman CM. NMDA receptors on non-dopaminergic neurons in the VTA support cocaine sensitization. Plos One. 5: e12141. PMID 20808436 DOI: 10.1371/journal.pone.0012141  1
2010 Hoffman AF, Laaris N, Kawamura M, Masino SA, Lupica CR. Control of cannabinoid CB1 receptor function on glutamate axon terminals by endogenous adenosine acting at A1 receptors. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 30: 545-55. PMID 20071517 DOI: 10.1523/JNEUROSCI.4920-09.2010  1
2009 Karlén A, Karlsson TE, Mattsson A, Lundströmer K, Codeluppi S, Pham TM, Bäckman CM, Ogren SO, Aberg E, Hoffman AF, Sherling MA, Lupica CR, Hoffer BJ, Spenger C, Josephson A, et al. Nogo receptor 1 regulates formation of lasting memories. Proceedings of the National Academy of Sciences of the United States of America. 106: 20476-81. PMID 19915139 DOI: 10.1073/pnas.0905390106  1
2009 Li X, Hoffman AF, Peng XQ, Lupica CR, Gardner EL, Xi ZX. Attenuation of basal and cocaine-enhanced locomotion and nucleus accumbens dopamine in cannabinoid CB1-receptor-knockout mice. Psychopharmacology. 204: 1-11. PMID 19099297 DOI: 10.1007/s00213-008-1432-0  1
2009 Fan H, Kotsikorou E, Hoffman AF, Ravert HT, Holt D, Hurst DP, Lupica CR, Reggio PH, Dannals RF, Horti AG. Analogs of JHU75528, a PET ligand for imaging of cerebral cannabinoid receptors (CB1): development of ligands with optimized lipophilicity and binding affinity. European Journal of Medicinal Chemistry. 44: 593-608. PMID 18511157 DOI: 10.1016/j.ejmech.2008.03.040  1
2008 Chen YH, Harvey BK, Hoffman AF, Wang Y, Chiang YH, Lupica CR. MPTP-induced deficits in striatal synaptic plasticity are prevented by glial cell line-derived neurotrophic factor expressed via an adeno-associated viral vector. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 22: 261-75. PMID 17690153 DOI: 10.1096/fj.07-8797com  1
2007 Hoffman AF, Oz M, Yang R, Lichtman AH, Lupica CR. Opposing actions of chronic Delta9-tetrahydrocannabinol and cannabinoid antagonists on hippocampal long-term potentiation. Learning & Memory (Cold Spring Harbor, N.Y.). 14: 63-74. PMID 17202425 DOI: 10.1101/lm.439007  1
2006 Hoffman AF, Lupica CR. Visualizing cannabinoid effects using brain slice imaging and electrophysiological approaches. Methods in Molecular Medicine. 123: 105-12. PMID 16506404  1
2005 Hoffman AF, Macgill AM, Smith D, Oz M, Lupica CR. Species and strain differences in the expression of a novel glutamate-modulating cannabinoid receptor in the rodent hippocampus. The European Journal of Neuroscience. 22: 2387-91. PMID 16262678 DOI: 10.1111/j.1460-9568.2005.04401.x  1
2004 Lupica CR, Riegel AC, Hoffman AF. Marijuana and cannabinoid regulation of brain reward circuits. British Journal of Pharmacology. 143: 227-34. PMID 15313883 DOI: 10.1038/sj.bjp.0705931  1
2003 Hoffman AF, Riegel AC, Lupica CR. Functional localization of cannabinoid receptors and endogenous cannabinoid production in distinct neuron populations of the hippocampus. The European Journal of Neuroscience. 18: 524-34. PMID 12911748 DOI: 10.1046/j.1460-9568.2003.02773.x  1
2003 Hoffman AF, Oz M, Caulder T, Lupica CR. Functional tolerance and blockade of long-term depression at synapses in the nucleus accumbens after chronic cannabinoid exposure. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 23: 4815-20. PMID 12832502  1
2003 Katoch-Rouse R, Pavlova OA, Caulder T, Hoffman AF, Mukhin AG, Horti AG. Synthesis, structure-activity relationship, and evaluation of SR141716 analogues: development of central cannabinoid receptor ligands with lower lipophilicity. Journal of Medicinal Chemistry. 46: 642-5. PMID 12570386 DOI: 10.1021/jm020157x  1
2001 Gerhardt GA, Hoffman AF. Effects of recording media composition on the responses of Nafion-coated carbon fiber microelectrodes measured using high-speed chronoamperometry. Journal of Neuroscience Methods. 109: 13-21. PMID 11489295 DOI: 10.1016/S0165-0270(01)00396-X  1
2001 Lupica CR, Bell JA, Hoffman AF, Watson PL. Contribution of the hyperpolarization-activated current (I(h)) to membrane potential and GABA release in hippocampal interneurons. Journal of Neurophysiology. 86: 261-8. PMID 11431507  1
2001 Hoffman AF, Lupica CR. Direct actions of cannabinoids on synaptic transmission in the nucleus accumbens: a comparison with opioids. Journal of Neurophysiology. 85: 72-83. PMID 11152707  1
2000 Hoffman AF, Lupica CR. Mechanisms of cannabinoid inhibition of GABA(A) synaptic transmission in the hippocampus. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 20: 2470-9. PMID 10729327  1
1999 Hoffman AF, Gerhardt GA. Differences in pharmacological properties of dopamine release between the substantia nigra and striatum: an in vivo electrochemical study. The Journal of Pharmacology and Experimental Therapeutics. 289: 455-63. PMID 10087038  1
1999 Hoffman AF, Zahniser NR, Lupica CR, Gerhardt GA. Voltage-dependency of the dopamine transporter in the rat substantia nigra. Neuroscience Letters. 260: 105-8. PMID 10025710 DOI: 10.1016/S0304-3940(98)00951-3  1
1998 Smith DA, Hoffman AF, David DJ, Adams CE, Gerhardt GA. Nicotine-evoked nitric oxide release in the rat hippocampal slice. Neuroscience Letters. 255: 127-30. PMID 9832189  1
1998 Hoffman AF, Lupica CR, Gerhardt GA. Dopamine transporter activity in the substantia nigra and striatum assessed by high-speed chronoamperometric recordings in brain slices. The Journal of Pharmacology and Experimental Therapeutics. 287: 487-96. PMID 9808671  1
1998 Hoffman AF, Gerhardt GA. In vivo electrochemical studies of dopamine clearance in the rat substantia nigra: effects of locally applied uptake inhibitors and unilateral 6-hydroxydopamine lesions. Journal of Neurochemistry. 70: 179-89. PMID 9422361  1
1998 Zahniser NR, Gerhardt GA, Hoffman AF, Lupica CR. Voltage-dependency of the dopamine transporter in rat brain. Advances in Pharmacology (San Diego, Calif.). 42: 195-8. PMID 9327877 DOI: 10.1016/S1054-3589(08)60726-7  1
1997 Hoffman AF, van Horne CG, Eken S, Hoffer BJ, Gerhardt GA. In vivo microdialysis studies on somatodendritic dopamine release in the rat substantia nigra: effects of unilateral 6-OHDA lesions and GDNF. Experimental Neurology. 147: 130-41. PMID 9294410 DOI: 10.1006/exnr.1997.6571  1
1995 Bowenkamp KE, Hoffman AF, Gerhardt GA, Henry MA, Biddle PT, Hoffer BJ, Granholm AC. Glial cell line-derived neurotrophic factor supports survival of injured midbrain dopaminergic neurons. The Journal of Comparative Neurology. 355: 479-89. PMID 7636027 DOI: 10.1002/cne.903550402  1
1994 Adams CE, Hoffman AF, Hudson JL, Hoffer BJ, Boyson SJ. Chronic treatment with levodopa and/or selegiline does not affect behavioral recovery induced by fetal ventral mesencephalic grafts in unilaterally 6-hydroxydopamine-lesioned rats. Experimental Neurology. 130: 261-8. PMID 7867755 DOI: 10.1006/exnr.1994.1204  1
Low-probability matches
2014 Bixler JN, Hokr B, Oian CA, Hoffman AF, Yakovlev VV, Thomas RJ. Modeling of tissue heating under tunable near IR radiation Progress in Biomedical Optics and Imaging - Proceedings of Spie. 9321. DOI: 10.1117/12.2079979  0.04
2013 Tang X, Peng R, Ren Y, Apparsundaram S, Deguzman J, Bauer CM, Hoffman AF, Hamilton S, Liang Z, Zeng H, Fuentes ME, Demartino JA, Kitson C, Stevenson CS, Budd DC. BET bromodomain proteins mediate downstream signaling events following growth factor stimulation in human lung fibroblasts and are involved in bleomycin-induced pulmonary fibrosis. Molecular Pharmacology. 83: 283-93. PMID 23115324 DOI: 10.1124/mol.112.081661  0.04
2012 Wei X, Hoffman AF, Hamilton SM, Xiang Q, He Y, So WV, So SS, Mark D. A simple statistical test to infer the causality of target/phenotype correlation from small molecule phenotypic screens. Bioinformatics (Oxford, England). 28: 301-5. PMID 22155864 DOI: 10.1093/bioinformatics/btr676  0.04
2011 Ewton DZ, Hu J, Vilenchik M, Deng X, Luk KC, Polonskaia A, Hoffman AF, Zipf K, Boylan JF, Friedman EA. Inactivation of mirk/dyrk1b kinase targets quiescent pancreatic cancer cells. Molecular Cancer Therapeutics. 10: 2104-14. PMID 21878655 DOI: 10.1158/1535-7163.MCT-11-0498  0.04
2010 Goodnow RA, Hicks A, Sidduri A, Kowalczyk A, Dominique R, Qiao Q, Lou JP, Gillespie P, Fotouhi N, Tilley J, Cohen N, Choudhry S, Cavallo G, Tannu SA, Ventre JD, ... ... Hoffman AF, et al. Discovery of novel and potent leukotriene B4 receptor antagonists. Part 1. Journal of Medicinal Chemistry. 53: 3502-16. PMID 20380377 DOI: 10.1021/jm1001919  0.04
2010 Hicks A, Goodnow R, Cavallo G, Tannu SA, Ventre JD, Lavelle D, Lora JM, Satjawatcharaphong J, Brovarney M, Dabbagh K, Tare NS, Oh H, Lamb M, Sidduri A, Dominique R, ... ... Hoffman AF, et al. Effects of LTB4 receptor antagonism on pulmonary inflammation in rodents and non-human primates. Prostaglandins & Other Lipid Mediators. 92: 33-43. PMID 20214997 DOI: 10.1016/j.prostaglandins.2010.02.003  0.04
2009 Shumate C, Hoffman AF. Instrumental considerations in high content screening Combinatorial Chemistry and High Throughput Screening. 12: 888-898. PMID 19531000 DOI: 10.2174/138620709789383231  0.04
2007 Hicks A, Monkarsh SP, Hoffman AF, Goodnow R. Leukotriene B4 receptor antagonists as therapeutics for inflammatory disease: Preclinical and clinical developments Expert Opinion On Investigational Drugs. 16: 1909-1920. PMID 18042000 DOI: 10.1517/13543784.16.12.1909  0.04
2007 Hoffman AF, Garippa RJ. A pharmaceutical company user's perspective on the potential of high content screening in drug discovery Methods in Molecular Biology (Clifton, N.J.). 356: 19-31. PMID 16988392  0.04
2007 Hoffman AF, Garippa RJ. HCS for HTS High Content Screening: Science, Techniques and Applications. 225-247. DOI: 10.1002/9780470229866.ch10  0.04
2006 Garippa RJ, Hoffman AF, Gradl G, Kirsch A. High-Throughput Confocal Microscopy for β-Arrestin-Green Fluorescent Protein Translocation G Protein-Coupled Receptor Assays Using the Evotec Opera Methods in Enzymology. 414: 99-120. PMID 17110189 DOI: 10.1016/S0076-6879(06)14007-0  0.04
2005 Hoffman AF. New microscopy techniques facilitate the deorphanization of GPCRs Microscopy and Microanalysis. 11: 180-181. DOI: 10.1017/S1431927605501594  0.04
2003 Hoffman AF. Peripheral vascular considerations Clinics in Podiatric Medicine and Surgery. 20: 527-545. PMID 12952052 DOI: 10.1016/S0891-8422(03)00038-7  0.01
1996 Hoffman AF, Driver VR. Onychomycosis Clinics in Podiatric Medicine and Surgery. 13: 13-29. PMID 8849929  0.01
1995 Parks TP, Hoffman AF, Homon CA, Graham AG, Lazer ES, Chilton FH, Borgeat P, Raible D, Schulman E, Bass DA. Inhibition of lipid mediator biosynthesis in human inflammatory cells by BIRM 270. Agents and Actions. Supplements. 46: 139-46. PMID 7610984  0.01
1994 Farina PR, Graham AG, Hoffman AF, Watrous JM, Borgeat P, Nadeau M, Hansen G, Dinallo RM, Adams J, Miao CK. BIRM 270: a novel inhibitor of arachidonate release that blocks leukotriene B4 and platelet-activating factor biosynthesis in human neutrophils. The Journal of Pharmacology and Experimental Therapeutics. 271: 1418-26. PMID 7996454  0.01
1992 Hoffman AF. Evaluation of arterial blood flow in the lower extremity Clinics in Podiatric Medicine and Surgery. 9: 19-56. PMID 1735062  0.01
1991 Hoffman AF, Schmugler BA, Matthews MJ. Normal digital pressure changes following the postocclusive reactive hyperemia test Journal of the American Podiatric Medical Association. 81: 57-61. PMID 1999800  0.01
1990 Parks TP, Lukas S, Hoffman AF. Purification and characterization of a phospholipase A2 from human osteoarthritic synovial fluid Advances in Experimental Medicine and Biology. 275: 55-81. PMID 2146857  0.01
1989 Adams SE, Hoffman AF. Multi-beat clonus in a patient without an upper motor neuron lesion. A case report Journal of the American Podiatric Medical Association. 79: 194-196. PMID 2567347  0.01
1985 Matteo MR, Hoffman AF, Collins-Boyce E. Comparative pharmacological effects on neutrophil enzyme release, oxidative burst and 5-lipoxygenase activity Federation Proceedings. 44.  0.01
1976 Hoffman AF. Letter: Three-year curriculum Journal of Medical Education. 51: 154-156. PMID 1249832  0.01
1976 Sandifer MG, Hoffman AF. Letters to the editor Journal of Medical Education. 51: 154-156.  0.01
1972 Hoffman AF. Recent concepts of skeletal muscle function. II. Factors affecting the development of tension in the isolated muscle Journal of the American Podiatry Association. 62: 53-59. PMID 5009683  0.01
1972 Hoffman AF. Recent concepts of skeletal muscle function. I. The anatomy of the muscle, muscle fiber and myofibril Journal of the American Podiatry Association. 62: 21-25. PMID 5008552  0.01
Hide low-probability matches.