Nahum Sonenberg, PhD - Publications

Affiliations: 
Biochemistry McGill University, Montreal, QC, Canada 
Area:
translational control

351 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2019 Wiebe S, Nagpal A, Truong VT, Park J, Skalecka A, He AJ, Gamache K, Khoutorsky A, Gantois I, Sonenberg N. Inhibitory interneurons mediate autism-associated behaviors via 4E-BP2. Proceedings of the National Academy of Sciences of the United States of America. PMID 31427534 DOI: 10.1073/pnas.1908126116  0.68
2019 Pelletier J, Sonenberg N. The Organizing Principles of Eukaryotic Ribosome Recruitment. Annual Review of Biochemistry. 88: 307-335. PMID 31220979 DOI: 10.1146/annurev-biochem-013118-111042  0.36
2019 Le Bacquer O, Combe K, Patrac V, Ingram B, Combaret L, Dardevet D, Montaurier C, Salles J, Giraudet C, Guillet C, Sonenberg N, Boirie Y, Walrand S. 4E-BP1 and 4E-BP2 double knockout mice are protected from aging-associated sarcopenia. Journal of Cachexia, Sarcopenia and Muscle. PMID 30927336 DOI: 10.1002/jcsm.12412  0.36
2018 Machida K, Shigeta T, Yamamoto Y, Ito T, Svitkin Y, Sonenberg N, Imataka H. Dynamic interaction of poly(A)-binding protein with the ribosome. Scientific Reports. 8: 17435. PMID 30487538 DOI: 10.1038/s41598-018-35753-1  0.56
2018 Megat S, Ray PR, Moy JK, Lou TF, Barragan-Iglesias P, Li Y, Pradhan G, Wanghzou A, Ahmad A, Burton MD, North RY, Dougherty PM, Khoutorsky A, Sonenberg N, Webster KR, et al. Nociceptor translational profiling reveals the Ragulator-Rag GTPase complex as a critical generator of neuropathic pain. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. PMID 30459229 DOI: 10.1523/JNEUROSCI.2661-18.2018  0.68
2018 Gantois I, Popic J, Khoutorsky A, Sonenberg N. Metformin for Treatment of Fragile X Syndrome and Other Neurological Disorders. Annual Review of Medicine. PMID 30365357 DOI: 10.1146/annurev-med-081117-041238  0.68
2018 Tahmasebi S, Khoutorsky A, Mathews MB, Sonenberg N. Translation deregulation in human disease. Nature Reviews. Molecular Cell Biology. PMID 30038383 DOI: 10.1038/s41580-018-0034-x  0.68
2018 Aguilar-Valles A, Haji N, De Gregorio D, Matta-Camacho E, Eslamizade MJ, Popic J, Sharma V, Cao R, Rummel C, Tanti A, Wiebe S, Nuñez N, Comai S, Nadon R, Luheshi G, ... ... Sonenberg N, et al. Translational control of depression-like behavior via phosphorylation of eukaryotic translation initiation factor 4E. Nature Communications. 9: 2459. PMID 29941989 DOI: 10.1038/s41467-018-04883-5  0.68
2018 Liu D, Stowie A, de Zavalia N, Leise T, Pathak SS, Drewes LR, Davidson AJ, Amir S, Sonenberg N, Cao R. mTOR signaling in VIP neurons regulates circadian clock synchrony and olfaction. Proceedings of the National Academy of Sciences of the United States of America. PMID 29555746 DOI: 10.1073/pnas.1721578115  0.4
2018 Ramon Y Cajal S, Castellvi J, Hümmer S, Peg V, Pelletier J, Sonenberg N. Beyond molecular tumor heterogeneity: protein synthesis takes control. Oncogene. PMID 29463861 DOI: 10.1038/s41388-018-0152-0  0.36
2018 Jafarnejad SM, Chapat C, Matta-Camacho E, Gelbart IA, Hesketh GG, Arguello M, Garzia A, Kim SH, Attig J, Shapiro M, Morita M, Khoutorsky A, Alain T, Gkogkas C, Stern-Ginossar N, ... ... Sonenberg N, et al. Translational control of ERK signaling through miRNA/4EHP-directed silencing. Elife. 7. PMID 29412140 DOI: 10.7554/eLife.35034  0.68
2017 Chu J, Cajal SRY, Sonenberg N, Pelletier J. Eukaryotic initiation factor 4F-sidestepping resistance mechanisms arising from expression heterogeneity. Current Opinion in Genetics & Development. 48: 89-96. PMID 29169064 DOI: 10.1016/j.gde.2017.11.002  0.36
2017 Cieplak-Rotowska MK, Tarnowski K, Rubin M, Fabian MR, Sonenberg N, Dadlez M, Niedzwiecka A. Structural Dynamics of the GW182 Silencing Domain Including its RNA Recognition motif (RRM) Revealed by Hydrogen-Deuterium Exchange Mass Spectrometry. Journal of the American Society For Mass Spectrometry. PMID 29080206 DOI: 10.1007/s13361-017-1830-9  0.48
2017 Martin LJ, Smith SB, Khoutorsky A, Magnussen CA, Samoshkin A, Sorge RE, Cho C, Yosefpour N, Sivaselvachandran S, Tohyama S, Cole T, Khuong TM, Mir E, Gibson DG, Wieskopf JS, ... ... Sonenberg N, et al. Epiregulin and EGFR interactions are involved in pain processing. The Journal of Clinical Investigation. PMID 28783046 DOI: 10.1172/JCI87406  0.68
2017 Moy JK, Khoutorsky A, Asiedu MN, Black BJ, Kuhn JL, Barragán-Iglesias P, Megat S, Burton MD, Burgos-Vega CC, Melemedjian OK, Boitano S, Vagner J, Gkogkas CG, Pancrazio JJ, Mogil JS, ... ... Sonenberg N, et al. The MNK - eIF4E signaling axis contributes to injury-induced nociceptive plasticity and the development of chronic pain. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. PMID 28674170 DOI: 10.1523/JNEUROSCI.0220-17.2017  0.84
2017 Gantois I, Khoutorsky A, Popic J, Aguilar-Valles A, Freemantle E, Cao R, Sharma V, Pooters T, Nagpal A, Skalecka A, Truong VT, Wiebe S, Groves IA, Jafarnejad SM, Chapat C, ... ... Sonenberg N, et al. Metformin ameliorates core deficits in a mouse model of fragile X syndrome. Nature Medicine. PMID 28504725 DOI: 10.1038/nm.4335  0.84
2017 Chapat C, Jafarnejad SM, Matta-Camacho E, Hesketh GG, Gelbart IA, Attig J, Gkogkas CG, Alain T, Stern-Ginossar N, Fabian MR, Gingras AC, Duchaine TF, Sonenberg N. Cap-binding protein 4EHP effects translation silencing by microRNAs. Proceedings of the National Academy of Sciences of the United States of America. PMID 28487484 DOI: 10.1073/pnas.1701488114  0.84
2017 Tuttle AH, Tansley S, Dossett K, Tohyama S, Khoutorsky A, Maldonado-Bouchard S, Stein L, Gerstein L, Crawhall-Duk H, Pearl R, Sukosd M, Leger P, Hardt OM, Yachnin D, Austin JS, ... ... Sonenberg N, et al. Social propinquity in rodents as measured by tube cooccupancy differs between inbred and outbred genotypes. Proceedings of the National Academy of Sciences of the United States of America. PMID 28484016 DOI: 10.1073/pnas.1703477114  0.84
2017 Svitkin YV, Cheng YM, Chakraborty T, Presnyak V, John M, Sonenberg N. N1-methyl-pseudouridine in mRNA enhances translation through eIF2α-dependent and independent mechanisms by increasing ribosome density. Nucleic Acids Research. PMID 28334758 DOI: 10.1093/nar/gkx135  0.56
2016 Tahmasebi S, Jafarnejad SM, Tam IS, Gonatopoulos-Pournatzis T, Matta-Camacho E, Tsukumo Y, Yanagiya A, Li W, Atlasi Y, Caron M, Braunschweig U, Pearl D, Khoutorsky A, Gkogkas CG, Nadon R, ... ... Sonenberg N, et al. Control of embryonic stem cell self-renewal and differentiation via coordinated alternative splicing and translation of YY2. Proceedings of the National Academy of Sciences of the United States of America. PMID 27791185 DOI: 10.1073/pnas.1615540113  0.84
2016 Khoutorsky A, Sorge RE, Prager-Khoutorsky M, Pawlowski SA, Longo G, Jafarnejad SM, Tahmasebi S, Martin LJ, Pitcher MH, Gkogkas CG, Sharif-Naeini R, Ribeiro-da-Silva A, Bourque CW, Cervero F, Mogil JS, ... Sonenberg N, et al. eIF2α phosphorylation controls thermal nociception. Proceedings of the National Academy of Sciences of the United States of America. PMID 27698114 DOI: 10.1073/pnas.1614047113  1
2016 Signer RA, Qi L, Zhao Z, Thompson D, Sigova AA, Fan ZP, DeMartino GN, Young RA, Sonenberg N, Morrison SJ. The rate of protein synthesis in hematopoietic stem cells is limited partly by 4E-BPs. Genes & Development. PMID 27492367 DOI: 10.1101/gad.282756.116  1
2016 Penney J, Tsurudome K, Liao EH, Kauwe G, Gray L, Yanagiya A, R Calderon M, Sonenberg N, Haghighi AP. LRRK2 regulates retrograde synaptic compensation at the Drosophila neuromuscular junction. Nature Communications. 7: 12188. PMID 27432119 DOI: 10.1038/ncomms12188  1
2016 Hinnebusch AG, Ivanov IP, Sonenberg N. Translational control by 5'-untranslated regions of eukaryotic mRNAs. Science (New York, N.Y.). 352: 1413-6. PMID 27313038 DOI: 10.1126/science.aad9868  1
2016 Skałecka A, Liszewska E, Bilinski R, Gkogkas C, Khoutorsky A, Malik AR, Sonenberg N, Jaworski J. mTOR kinase is needed for the development and stabilization of dendritic arbors in newly born olfactory bulb neurons. Developmental Neurobiology. PMID 27008592 DOI: 10.1002/dneu.22392  1
2015 Khoutorsky A, Bonin RP, Sorge RE, Gkogkas CG, Pawlowski SA, Jafarnejad SM, Pitcher MH, Alain T, Perez-Sanchez J, Salter EW, Martin L, Ribeiro-da-Silva A, De Koninck Y, Cervero F, Mogil JS, ... Sonenberg N, et al. Translational control of nociception via 4E-binding protein 1. Elife. 4. PMID 26678009 DOI: 10.7554/eLife.12002  1
2015 Siddiqui N, Sonenberg N. Signalling to eIF4E in cancer. Biochemical Society Transactions. 43: 763-72. PMID 26517881 DOI: 10.1042/BST20150126  1
2015 Maity S, Rah S, Sonenberg N, Gkogkas CG, Nguyen PV. Norepinephrine triggers metaplasticity of LTP by increasing translation of specific mRNAs. Learning & Memory (Cold Spring Harbor, N.Y.). 22: 499-508. PMID 26373828 DOI: 10.1101/lm.039222.115  1
2015 Aguilar-Valles A, Matta-Camacho E, Khoutorsky A, Gkogkas C, Nader K, Lacaille JC, Sonenberg N. Inhibition of Group I Metabotropic Glutamate Receptors Reverses Autistic-Like Phenotypes Caused by Deficiency of the Translation Repressor eIF4E Binding Protein 2. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 35: 11125-32. PMID 26245973 DOI: 10.1523/JNEUROSCI.4615-14.2015  1
2015 Zidek LM, Ackermann T, Hartleben G, Eichwald S, Kortman G, Kiehntopf M, Leutz A, Sonenberg N, Wang ZQ, von Maltzahn J, Müller C, Calkhoven CF. Deficiency in mTORC1-controlled C/EBPβ-mRNA translation improves metabolic health in mice. Embo Reports. PMID 26113365 DOI: 10.15252/embr.201439837  1
2015 Topisirovic I, Sonenberg N. Translation and cancer. Biochimica Et Biophysica Acta. 1849: 751-2. PMID 25988403 DOI: 10.1016/j.bbagrm.2015.05.004  1
2015 Martínez A, Sesé M, Losa JH, Robichaud N, Sonenberg N, Aasen T, Ramón Y Cajal S. Phosphorylation of eIF4E Confers Resistance to Cellular Stress and DNA-Damaging Agents through an Interaction with 4E-T: A Rationale for Novel Therapeutic Approaches. Plos One. 10: e0123352. PMID 25923732 DOI: 10.1371/journal.pone.0123352  1
2015 Cao R, Gkogkas CG, de Zavalia N, Blum ID, Yanagiya A, Tsukumo Y, Xu H, Lee C, Storch KF, Liu AC, Amir S, Sonenberg N. Light-regulated translational control of circadian behavior by eIF4E phosphorylation. Nature Neuroscience. 18: 855-62. PMID 25915475 DOI: 10.1038/nn.4010  1
2015 Aulas A, Caron G, Gkogkas CG, Mohamed NV, Destroismaisons L, Sonenberg N, Leclerc N, Parker JA, Vande Velde C. G3BP1 promotes stress-induced RNA granule interactions to preserve polyadenylated mRNA. The Journal of Cell Biology. 209: 73-84. PMID 25847539 DOI: 10.1083/jcb.201408092  1
2015 Arulanandam R, Batenchuk C, Varette O, Zakaria C, Garcia V, Forbes NE, Davis C, Krishnan R, Karmacharya R, Cox J, Sinha A, Babawy A, Waite K, Weinstein E, Falls T, ... ... Sonenberg N, et al. Microtubule disruption synergizes with oncolytic virotherapy by inhibiting interferon translation and potentiating bystander killing. Nature Communications. 6: 6410. PMID 25817275 DOI: 10.1038/ncomms7410  1
2015 Filipowicz W, Sonenberg N. The long unfinished march towards understanding microRNA-mediated repression. Rna (New York, N.Y.). 21: 519-24. PMID 25780122 DOI: 10.1261/rna.051219.115  1
2015 Liberman N, Gandin V, Svitkin YV, David M, Virgili G, Jaramillo M, Holcik M, Nagar B, Kimchi A, Sonenberg N. DAP5 associates with eIF2β and eIF4AI to promote Internal Ribosome Entry Site driven translation. Nucleic Acids Research. 43: 3764-75. PMID 25779044 DOI: 10.1093/nar/gkv205  1
2015 Bhat M, Robichaud N, Hulea L, Sonenberg N, Pelletier J, Topisirovic I. Targeting the translation machinery in cancer. Nature Reviews. Drug Discovery. 14: 261-78. PMID 25743081 DOI: 10.1038/nrd4505  1
2015 Sinvani H, Haimov O, Svitkin Y, Sonenberg N, Tamarkin-Ben-Harush A, Viollet B, Dikstein R. Translational tolerance of mitochondrial genes to metabolic energy stress involves TISU and eIF1-eIF4GI cooperation in start codon selection. Cell Metabolism. 21: 479-92. PMID 25738462 DOI: 10.1016/j.cmet.2015.02.010  1
2015 Pelletier J, Graff J, Ruggero D, Sonenberg N. Targeting the eIF4F translation initiation complex: a critical nexus for cancer development. Cancer Research. 75: 250-63. PMID 25593033 DOI: 10.1158/0008-5472.CAN-14-2789  1
2015 Bah A, Vernon RM, Siddiqui Z, Krzeminski M, Muhandiram R, Zhao C, Sonenberg N, Kay LE, Forman-Kay JD. Folding of an intrinsically disordered protein by phosphorylation as a regulatory switch. Nature. 519: 106-9. PMID 25533957 DOI: 10.1038/nature13999  1
2015 Faller WJ, Jackson TJ, Knight JR, Ridgway RA, Jamieson T, Karim SA, Jones C, Radulescu S, Huels DJ, Myant KB, Dudek KM, Casey HA, Scopelliti A, Cordero JB, Vidal M, ... ... Sonenberg N, et al. mTORC1-mediated translational elongation limits intestinal tumour initiation and growth. Nature. 517: 497-500. PMID 25383520 DOI: 10.1038/nature13896  1
2015 Robichaud N, del Rincon SV, Huor B, Alain T, Petruccelli LA, Hearnden J, Goncalves C, Grotegut S, Spruck CH, Furic L, Larsson O, Muller WJ, Miller WH, Sonenberg N. Phosphorylation of eIF4E promotes EMT and metastasis via translational control of SNAIL and MMP-3. Oncogene. 34: 2032-42. PMID 24909168 DOI: 10.1038/onc.2014.146  1
2015 Im YK, La Selva R, Gandin V, Ha JR, Sabourin V, Sonenberg N, Pawson T, Topisirovic I, Ursini-Siegel J. The ShcA adaptor activates AKT signaling to potentiate breast tumor angiogenesis by stimulating VEGF mRNA translation in a 4E-BP-dependent manner. Oncogene. 34: 1729-35. PMID 24837366 DOI: 10.1038/onc.2014.110  1
2014 Gkogkas CG, Khoutorsky A, Cao R, Jafarnejad SM, Prager-Khoutorsky M, Giannakas N, Kaminari A, Fragkouli A, Nader K, Price TJ, Konicek BW, Graff JR, Tzinia AK, Lacaille JC, Sonenberg N. Pharmacogenetic inhibition of eIF4E-dependent Mmp9 mRNA translation reverses fragile X syndrome-like phenotypes. Cell Reports. 9: 1742-55. PMID 25466251 DOI: 10.1016/j.celrep.2014.10.064  1
2014 Fukao A, Mishima Y, Takizawa N, Oka S, Imataka H, Pelletier J, Sonenberg N, Thoma C, Fujiwara T. MicroRNAs trigger dissociation of eIF4AI and eIF4AII from target mRNAs in humans. Molecular Cell. 56: 79-89. PMID 25280105 DOI: 10.1016/j.molcel.2014.09.005  1
2014 Topisirovic I, Sonenberg N. Distinctive tRNA repertoires in proliferating versus differentiating cells. Cell. 158: 1238-9. PMID 25215483 DOI: 10.1016/j.cell.2014.08.031  1
2014 Ramon Y Cajal S, De Mattos-Arruda L, Sonenberg N, Cortes J, Peg V. The intra-tumor heterogeneity of cell signaling factors in breast cancer: p4E-BP1 and peIF4E are diffusely expressed and are real potential targets. Clinical & Translational Oncology : Official Publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico. 16: 937-41. PMID 25060567 DOI: 10.1007/s12094-014-1203-9  1
2014 Rouya C, Siddiqui N, Morita M, Duchaine TF, Fabian MR, Sonenberg N. Human DDX6 effects miRNA-mediated gene silencing via direct binding to CNOT1. Rna (New York, N.Y.). 20: 1398-409. PMID 25035296 DOI: 10.1261/rna.045302.114  1
2014 Sun Y, Atas E, Lindqvist LM, Sonenberg N, Pelletier J, Meller A. Single-molecule kinetics of the eukaryotic initiation factor 4AI upon RNA unwinding. Structure (London, England : 1993). 22: 941-8. PMID 24909782 DOI: 10.1016/j.str.2014.04.014  1
2014 Liew CW, Assmann A, Templin AT, Raum JC, Lipson KL, Rajan S, Qiang G, Hu J, Kawamori D, Lindberg I, Philipson LH, Sonenberg N, Goldfine AB, Stoffers DA, Mirmira RG, et al. Insulin regulates carboxypeptidase E by modulating translation initiation scaffolding protein eIF4G1 in pancreatic β cells. Proceedings of the National Academy of Sciences of the United States of America. 111: E2319-28. PMID 24843127 DOI: 10.1073/pnas.1323066111  1
2014 Piccirillo CA, Bjur E, Topisirovic I, Sonenberg N, Larsson O. Translational control of immune responses: from transcripts to translatomes. Nature Immunology. 15: 503-11. PMID 24840981 DOI: 10.1038/ni.2891  1
2014 Jung H, Gkogkas CG, Sonenberg N, Holt CE. Remote control of gene function by local translation. Cell. 157: 26-40. PMID 24679524 DOI: 10.1016/j.cell.2014.03.005  1
2014 Yamamoto K, Gandin V, Sasaki M, McCracken S, Li W, Silvester JL, Elia AJ, Wang F, Wakutani Y, Alexandrova R, Oo YD, Mullen PJ, Inoue S, Itsumi M, Lapin V, ... ... Sonenberg N, et al. Largen: a molecular regulator of mammalian cell size control. Molecular Cell. 53: 904-15. PMID 24656129 DOI: 10.1016/j.molcel.2014.02.028  1
2014 Tahmasebi S, Alain T, Rajasekhar VK, Zhang JP, Prager-Khoutorsky M, Khoutorsky A, Dogan Y, Gkogkas CG, Petroulakis E, Sylvestre A, Ghorbani M, Assadian S, Yamanaka Y, Vinagolu-Baur JR, Teodoro JG, ... ... Sonenberg N, et al. Multifaceted regulation of somatic cell reprogramming by mRNA translational control. Cell Stem Cell. 14: 606-16. PMID 24630793 DOI: 10.1016/j.stem.2014.02.005  1
2014 Gigoux M, Lovato A, Leconte J, Leung J, Sonenberg N, Suh WK. Inducible costimulator facilitates T-dependent B cell activation by augmenting IL-4 translation. Molecular Immunology. 59: 46-54. PMID 24486724 DOI: 10.1016/j.molimm.2014.01.008  1
2014 Martineau Y, Wang X, Alain T, Petroulakis E, Shahbazian D, Fabre B, Bousquet-Dubouch MP, Monsarrat B, Pyronnet S, Sonenberg N. Control of Paip1-eukayrotic translation initiation factor 3 interaction by amino acids through S6 kinase. Molecular and Cellular Biology. 34: 1046-53. PMID 24396066 DOI: 10.1128/MCB.01079-13  1
2014 Han K, Jaimovich A, Dey G, Ruggero D, Meyuhas O, Sonenberg N, Meyer T. Parallel measurement of dynamic changes in translation rates in single cells. Nature Methods. 11: 86-93. PMID 24213167 DOI: 10.1038/nmeth.2729  1
2014 Robichaud N, Sonenberg N. EIF4E and its binding proteins Translation and Its Regulation in Cancer Biology and Medicine. 73-113. DOI: 10.1007/978-94-017-9078-9_4  1
2014 Bhat M, Metrakos P, Ramon Y Cajal S, Sonenberg N, Alain T. Pancreatic neuroendocrine tumors Translation and Its Regulation in Cancer Biology and Medicine. 631-643. DOI: 10.1007/978-94-017-9078-9_31  1
2014 MacParland SA, Bilodeau M, Grebely J, Bruneau J, Cooper C, Klein M, Sagan SM, Choucha N, Balfour L, Bialystok F, Krajden M, Raven J, Roberts E, Russell R, Houghton M, ... ... Sonenberg N, et al. The 3rd Canadian symposium on Hepatitis c Virus: Expanding care in the interferon-free era Canadian Journal of Gastroenterology and Hepatology. 28: 481-487.  1
2013 Gkogkas CG, Sonenberg N. Translational control and autism-like behaviors. Cellular Logistics. 3: e24551. PMID 24516777 DOI: 10.4161/cl.24551  0.84
2013 Lukhele S, Bah A, Lin H, Sonenberg N, Forman-Kay JD. Interaction of the eukaryotic initiation factor 4E with 4E-BP2 at a dynamic bipartite interface. Structure (London, England : 1993). 21: 2186-96. PMID 24207126 DOI: 10.1016/j.str.2013.08.030  1
2013 Morita M, Gravel SP, Chénard V, Sikström K, Zheng L, Alain T, Gandin V, Avizonis D, Arguello M, Zakaria C, McLaughlan S, Nouet Y, Pause A, Pollak M, Gottlieb E, ... ... Sonenberg N, et al. mTORC1 controls mitochondrial activity and biogenesis through 4E-BP-dependent translational regulation. Cell Metabolism. 18: 698-711. PMID 24206664 DOI: 10.1016/j.cmet.2013.10.001  1
2013 Cao R, Robinson B, Xu H, Gkogkas C, Khoutorsky A, Alain T, Yanagiya A, Nevarko T, Liu AC, Amir S, Sonenberg N. Translational control of entrainment and synchrony of the suprachiasmatic circadian clock by mTOR/4E-BP1 signaling. Neuron. 79: 712-24. PMID 23972597 DOI: 10.1016/j.neuron.2013.06.026  1
2013 Sidrauski C, Acosta-Alvear D, Khoutorsky A, Vedantham P, Hearn BR, Li H, Gamache K, Gallagher CM, Ang KK, Wilson C, Okreglak V, Ashkenazi A, Hann B, Nader K, Arkin MR, ... ... Sonenberg N, et al. Pharmacological brake-release of mRNA translation enhances cognitive memory. Elife. 2: e00498. PMID 23741617 DOI: 10.7554/eLife.00498  1
2013 Hernández G, Miron M, Han H, Liu N, Magescas J, Tettweiler G, Frank F, Siddiqui N, Sonenberg N, Lasko P. Mextli is a novel eukaryotic translation initiation factor 4E-binding protein that promotes translation in Drosophila melanogaster. Molecular and Cellular Biology. 33: 2854-64. PMID 23716590 DOI: 10.1128/MCB.01354-12  1
2013 Svitkin YV, Yanagiya A, Karetnikov AE, Alain T, Fabian MR, Khoutorsky A, Perreault S, Topisirovic I, Sonenberg N. Control of translation and miRNA-dependent repression by a novel poly(A) binding protein, hnRNP-Q. Plos Biology. 11: e1001564. PMID 23700384 DOI: 10.1371/journal.pbio.1001564  1
2013 Bjur E, Larsson O, Yurchenko E, Zheng L, Gandin V, Topisirovic I, Li S, Wagner CR, Sonenberg N, Piccirillo CA. Distinct translational control in CD4+ T cell subsets. Plos Genetics. 9: e1003494. PMID 23658533 DOI: 10.1371/journal.pgen.1003494  1
2013 Fabian MR, Frank F, Rouya C, Siddiqui N, Lai WS, Karetnikov A, Blackshear PJ, Nagar B, Sonenberg N. Structural basis for the recruitment of the human CCR4-NOT deadenylase complex by tristetraprolin. Nature Structural & Molecular Biology. 20: 735-9. PMID 23644599 DOI: 10.1038/nsmb.2572  1
2013 Khoutorsky A, Yanagiya A, Gkogkas CG, Fabian MR, Prager-Khoutorsky M, Cao R, Gamache K, Bouthiette F, Parsyan A, Sorge RE, Mogil JS, Nader K, Lacaille JC, Sonenberg N. Control of synaptic plasticity and memory via suppression of poly(A)-binding protein. Neuron. 78: 298-311. PMID 23622065 DOI: 10.1016/j.neuron.2013.02.025  1
2013 Gandin V, Gutierrez GJ, Brill LM, Varsano T, Feng Y, Aza-Blanc P, Au Q, McLaughlan S, Ferreira TA, Alain T, Sonenberg N, Topisirovic I, Ronai ZA. Degradation of newly synthesized polypeptides by ribosome-associated RACK1/c-Jun N-terminal kinase/eukaryotic elongation factor 1A2 complex. Molecular and Cellular Biology. 33: 2510-26. PMID 23608534 DOI: 10.1128/MCB.01362-12  1
2013 Melemedjian OK, Khoutorsky A, Sorge RE, Yan J, Asiedu MN, Valdez A, Ghosh S, Dussor G, Mogil JS, Sonenberg N, Price TJ. mTORC1 inhibition induces pain via IRS-1-dependent feedback activation of ERK. Pain. 154: 1080-91. PMID 23607966 DOI: 10.1016/j.pain.2013.03.021  1
2013 Chaveroux C, Eichner LJ, Dufour CR, Shatnawi A, Khoutorsky A, Bourque G, Sonenberg N, Giguère V. Molecular and genetic crosstalks between mTOR and ERRα are key determinants of rapamycin-induced nonalcoholic fatty liver. Cell Metabolism. 17: 586-98. PMID 23562079 DOI: 10.1016/j.cmet.2013.03.003  1
2013 Fournier MJ, Coudert L, Mellaoui S, Adjibade P, Gareau C, Côté MF, Sonenberg N, Gaudreault RC, Mazroui R. Inactivation of the mTORC1-eukaryotic translation initiation factor 4E pathway alters stress granule formation. Molecular and Cellular Biology. 33: 2285-301. PMID 23547259 DOI: 10.1128/MCB.01517-12  1
2013 Sonenberg N, Hay N. Cancer genomics: the post-transcriptional era. Current Opinion in Genetics & Development. 23: 1-2. PMID 23523342 DOI: 10.1016/j.gde.2013.02.016  1
2013 Tamai T, Yamaguchi O, Hikoso S, Takeda T, Taneike M, Oka T, Oyabu J, Murakawa T, Nakayama H, Uno Y, Horie K, Nishida K, Sonenberg N, Shah AM, Takeda J, et al. Rheb (Ras homologue enriched in brain)-dependent mammalian target of rapamycin complex 1 (mTORC1) activation becomes indispensable for cardiac hypertrophic growth after early postnatal period. The Journal of Biological Chemistry. 288: 10176-87. PMID 23426372 DOI: 10.1074/jbc.M112.423640  1
2013 Bhat M, Sonenberg N, Gores GJ. The mTOR pathway in hepatic malignancies. Hepatology (Baltimore, Md.). 58: 810-8. PMID 23408390 DOI: 10.1002/hep.26323  1
2013 Stern E, Chinnakkaruppan A, David O, Sonenberg N, Rosenblum K. Blocking the eIF2α kinase (PKR) enhances positive and negative forms of cortex-dependent taste memory. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 33: 2517-25. PMID 23392680 DOI: 10.1523/JNEUROSCI.2322-12.2013  1
2013 Ran I, Gkogkas CG, Vasuta C, Tartas M, Khoutorsky A, Laplante I, Parsyan A, Nevarko T, Sonenberg N, Lacaille JC. Selective regulation of GluA subunit synthesis and AMPA receptor-mediated synaptic function and plasticity by the translation repressor 4E-BP2 in hippocampal pyramidal cells. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 33: 1872-86. PMID 23365227 DOI: 10.1523/JNEUROSCI.3264-12.2013  1
2013 Larsson O, Tian B, Sonenberg N. Toward a genome-wide landscape of translational control. Cold Spring Harbor Perspectives in Biology. 5: a012302. PMID 23209130 DOI: 10.1101/cshperspect.a012302  1
2013 Gkogkas CG, Khoutorsky A, Ran I, Rampakakis E, Nevarko T, Weatherill DB, Vasuta C, Yee S, Truitt M, Dallaire P, Major F, Lasko P, Ruggero D, Nader K, Lacaille JC, ... Sonenberg N, et al. Autism-related deficits via dysregulated eIF4E-dependent translational control. Nature. 493: 371-7. PMID 23172145 DOI: 10.1038/nature11628  1
2012 Alain T, Sonenberg N, Topisirovic I. mTOR inhibitor efficacy is determined by the eIF4E/4E-BP ratio. Oncotarget. 3: 1491-2. PMID 23455427  1
2012 Hershey JW, Sonenberg N, Mathews MB. Principles of translational control: an overview. Cold Spring Harbor Perspectives in Biology. 4. PMID 23209153 DOI: 10.1101/cshperspect.a011528  1
2012 Alain T, Morita M, Fonseca BD, Yanagiya A, Siddiqui N, Bhat M, Zammit D, Marcus V, Metrakos P, Voyer LA, Gandin V, Liu Y, Topisirovic I, Sonenberg N. eIF4E/4E-BP ratio predicts the efficacy of mTOR targeted therapies. Cancer Research. 72: 6468-76. PMID 23100465 DOI: 10.1158/0008-5472.CAN-12-2395  1
2012 Mohr I, Sonenberg N. Host translation at the nexus of infection and immunity. Cell Host & Microbe. 12: 470-83. PMID 23084916 DOI: 10.1016/j.chom.2012.09.006  1
2012 Frank F, Hauver J, Sonenberg N, Nagar B. Arabidopsis Argonaute MID domains use their nucleotide specificity loop to sort small RNAs. The Embo Journal. 31: 3588-95. PMID 22850669 DOI: 10.1038/emboj.2012.204  1
2012 Hernández G, Han H, Gandin V, Fabian L, Ferreira T, Zuberek J, Sonenberg N, Brill JA, Lasko P. Eukaryotic initiation factor 4E-3 is essential for meiotic chromosome segregation, cytokinesis and male fertility in Drosophila. Development (Cambridge, England). 139: 3211-20. PMID 22833128 DOI: 10.1242/dev.073122  1
2012 Sonenberg N, Filipowicz W. Retrospective. Aaron Shatkin (1934-2012). Science (New York, N.Y.). 337: 309. PMID 22822142 DOI: 10.1126/science.1226820  1
2012 Morita M, Ler LW, Fabian MR, Siddiqui N, Mullin M, Henderson VC, Alain T, Fonseca BD, Karashchuk G, Bennett CF, Kabuta T, Higashi S, Larsson O, Topisirovic I, Smith RJ, ... ... Sonenberg N, et al. A novel 4EHP-GIGYF2 translational repressor complex is essential for mammalian development. Molecular and Cellular Biology. 32: 3585-93. PMID 22751931 DOI: 10.1128/MCB.00455-12  1
2012 Tettweiler G, Kowanda M, Lasko P, Sonenberg N, Hernández G. The Distribution of eIF4E-Family Members across Insecta. Comparative and Functional Genomics. 2012: 960420. PMID 22745595 DOI: 10.1155/2012/960420  1
2012 Fabian MR, Sonenberg N. The mechanics of miRNA-mediated gene silencing: a look under the hood of miRISC. Nature Structural & Molecular Biology. 19: 586-93. PMID 22664986 DOI: 10.1038/nsmb.2296  1
2012 Larsson O, Morita M, Topisirovic I, Alain T, Blouin MJ, Pollak M, Sonenberg N. Distinct perturbation of the translatome by the antidiabetic drug metformin. Proceedings of the National Academy of Sciences of the United States of America. 109: 8977-82. PMID 22611195 DOI: 10.1073/pnas.1201689109  1
2012 Yanagiya A, Suyama E, Adachi H, Svitkin YV, Aza-Blanc P, Imataka H, Mikami S, Martineau Y, Ronai ZA, Sonenberg N. Translational homeostasis via the mRNA cap-binding protein, eIF4E. Molecular Cell. 46: 847-58. PMID 22578813 DOI: 10.1016/j.molcel.2012.04.004  1
2012 Herdy B, Jaramillo M, Svitkin YV, Rosenfeld AB, Kobayashi M, Walsh D, Alain T, Sean P, Robichaud N, Topisirovic I, Furic L, Dowling RJ, Sylvestre A, Rong L, Colina R, ... ... Sonenberg N, et al. Translational control of the activation of transcription factor NF-κB and production of type I interferon by phosphorylation of the translation factor eIF4E. Nature Immunology. 13: 543-50. PMID 22544393 DOI: 10.1038/ni.2291  1
2012 Srivastava T, Fortin DA, Nygaard S, Kaech S, Sonenberg N, Edelman AM, Soderling TR. Regulation of neuronal mRNA translation by CaM-kinase I phosphorylation of eIF4GII. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 32: 5620-30. PMID 22514323 DOI: 10.1523/JNEUROSCI.0030-12.2012  1
2012 Penney J, Tsurudome K, Liao EH, Elazzouzi F, Livingstone M, Gonzalez M, Sonenberg N, Haghighi AP. TOR is required for the retrograde regulation of synaptic homeostasis at the Drosophila neuromuscular junction. Neuron. 74: 166-78. PMID 22500638 DOI: 10.1016/j.neuron.2012.01.030  1
2012 Fonseca BD, Diering GH, Bidinosti MA, Dalal K, Alain T, Balgi AD, Forestieri R, Nodwell M, Rajadurai CV, Gunaratnam C, Tee AR, Duong F, Andersen RJ, Orlowski J, Numata M, ... Sonenberg N, et al. Structure-activity analysis of niclosamide reveals potential role for cytoplasmic pH in control of mammalian target of rapamycin complex 1 (mTORC1) signaling. The Journal of Biological Chemistry. 287: 17530-45. PMID 22474287 DOI: 10.1074/jbc.M112.359638  1
2012 Sun Y, Atas E, Lindqvist L, Sonenberg N, Pelletier J, Meller A. The eukaryotic initiation factor eIF4H facilitates loop-binding, repetitive RNA unwinding by the eIF4A DEAD-box helicase. Nucleic Acids Research. 40: 6199-207. PMID 22457067 DOI: 10.1093/nar/gks278  1
2012 Lin J, Fabian M, Sonenberg N, Meller A. Nanopore detachment kinetics of poly(A) binding proteins from RNA molecules reveals the critical role of C-terminus interactions. Biophysical Journal. 102: 1427-34. PMID 22455926 DOI: 10.1016/j.bpj.2012.02.025  1
2012 Chenoweth MJ, Mian MF, Barra NG, Alain T, Sonenberg N, Bramson J, Lichty BD, Richards CD, Ma A, Ashkar AA. IL-15 can signal via IL-15Rα, JNK, and NF-κB to drive RANTES production by myeloid cells. Journal of Immunology (Baltimore, Md. : 1950). 188: 4149-57. PMID 22447977 DOI: 10.4049/jimmunol.1101883  1
2012 Li Z, Miard S, Laplante M, Sonenberg N, Picard F. Insulin stimulates IGFBP-2 expression in 3T3-L1 adipocytes through the PI3K/mTOR pathway. Molecular and Cellular Endocrinology. 358: 63-8. PMID 22410287 DOI: 10.1016/j.mce.2012.02.022  1
2012 Kundu P, Fabian MR, Sonenberg N, Bhattacharyya SN, Filipowicz W. HuR protein attenuates miRNA-mediated repression by promoting miRISC dissociation from the target RNA. Nucleic Acids Research. 40: 5088-100. PMID 22362743 DOI: 10.1093/nar/gks148  1
2012 Nogueira V, Sundararajan D, Kwan JM, Peng XD, Sarvepalli N, Sonenberg N, Hay N. Akt-dependent Skp2 mRNA translation is required for exiting contact inhibition, oncogenesis, and adipogenesis. The Embo Journal. 31: 1134-46. PMID 22307088 DOI: 10.1038/emboj.2011.478  1
2012 Delbes G, Yanagiya A, Sonenberg N, Robaire B. PABP interacting protein 2A (PAIP2A) regulates specific key proteins during spermiogenesis in the mouse. Biology of Reproduction. 86: 95. PMID 22190698 DOI: 10.1095/biolreprod.111.092619  1
2012 Fujiwara T, Fukao A, Sasano Y, Matsuzaki H, Kikkawa U, Imataka H, Inoue K, Endo S, Sonenberg N, Thoma C, Sakamoto H. Functional and direct interaction between the RNA binding protein HuD and active Akt1. Nucleic Acids Research. 40: 1944-53. PMID 22075994 DOI: 10.1093/nar/gkr979  1
2012 Pons B, Armengol G, Livingstone M, López L, Coch L, Sonenberg N, Ramón y Cajal S. Association between LRRK2 and 4E-BP1 protein levels in normal and malignant cells. Oncology Reports. 27: 225-31. PMID 21922152 DOI: 10.3892/or.2011.1462  1
2011 Marcet-Palacios M, Duggan BL, Shostak I, Barry M, Geskes T, Wilkins JA, Yanagiya A, Sonenberg N, Bleackley RC. Granzyme B inhibits vaccinia virus production through proteolytic cleavage of eukaryotic initiation factor 4 gamma 3. Plos Pathogens. 7: e1002447. PMID 22194691 DOI: 10.1371/journal.ppat.1002447  1
2011 Topisirovic I, Sonenberg N. mRNA translation and energy metabolism in cancer: the role of the MAPK and mTORC1 pathways. Cold Spring Harbor Symposia On Quantitative Biology. 76: 355-67. PMID 22123850 DOI: 10.1101/sqb.2011.76.010785  1
2011 Vosler PS, Gao Y, Brennan CS, Yanagiya A, Gan Y, Cao G, Zhang F, Morley SJ, Sonenberg N, Bennett MV, Chen J. Ischemia-induced calpain activation causes eukaryotic (translation) initiation factor 4G1 (eIF4GI) degradation, protein synthesis inhibition, and neuronal death. Proceedings of the National Academy of Sciences of the United States of America. 108: 18102-7. PMID 22006312 DOI: 10.1073/pnas.1112635108  1
2011 Fabian MR, Cieplak MK, Frank F, Morita M, Green J, Srikumar T, Nagar B, Yamamoto T, Raught B, Duchaine TF, Sonenberg N. miRNA-mediated deadenylation is orchestrated by GW182 through two conserved motifs that interact with CCR4-NOT. Nature Structural & Molecular Biology. 18: 1211-7. PMID 21984185 DOI: 10.1038/nsmb.2149  1
2011 Topisirovic I, Svitkin YV, Sonenberg N, Shatkin AJ. Cap and cap-binding proteins in the control of gene expression. Wiley Interdisciplinary Reviews. Rna. 2: 277-98. PMID 21957010 DOI: 10.1002/wrna.52  1
2011 Melemedjian OK, Asiedu MN, Tillu DV, Sanoja R, Yan J, Lark A, Khoutorsky A, Johnson J, Peebles KA, Lepow T, Sonenberg N, Dussor G, Price TJ. Targeting adenosine monophosphate-activated protein kinase (AMPK) in preclinical models reveals a potential mechanism for the treatment of neuropathic pain. Molecular Pain. 7: 70. PMID 21936900 DOI: 10.1186/1744-8069-7-70  1
2011 Chartier-Harlin MC, Dachsel JC, Vilariño-Güell C, Lincoln SJ, Leprêtre F, Hulihan MM, Kachergus J, Milnerwood AJ, Tapia L, Song MS, Le Rhun E, Mutez E, Larvor L, Duflot A, Vanbesien-Mailliot C, ... ... Sonenberg N, et al. Translation initiator EIF4G1 mutations in familial Parkinson disease. American Journal of Human Genetics. 89: 398-406. PMID 21907011 DOI: 10.1016/j.ajhg.2011.08.009  1
2011 Burley SK, Sonenberg N. Gimme phospho-serine five! Capping enzyme guanylyltransferase recognition of the RNA polymerase II CTD. Molecular Cell. 43: 163-5. PMID 21777807 DOI: 10.1016/j.molcel.2011.07.003  1
2011 Elfakess R, Sinvani H, Haimov O, Svitkin Y, Sonenberg N, Dikstein R. Unique translation initiation of mRNAs-containing TISU element. Nucleic Acids Research. 39: 7598-609. PMID 21705780 DOI: 10.1093/nar/gkr484  1
2011 Burke JD, Sonenberg N, Platanias LC, Fish EN. Antiviral effects of interferon-β are enhanced in the absence of the translational suppressor 4E-BP1 in myocarditis induced by Coxsackievirus B3. Antiviral Therapy. 16: 577-84. PMID 21685545 DOI: 10.3851/IMP1752  1
2011 Topisirovic I, Sonenberg N. Translational control by the eukaryotic ribosome. Cell. 145: 333-4. PMID 21529706 DOI: 10.1016/j.cell.2011.04.006  1
2011 Fabian MR, Svitkin YV, Sonenberg N. An efficient system for let-7 microRNA and GW182 protein-mediated deadenylation in vitro. Methods in Molecular Biology (Clifton, N.J.). 725: 207-17. PMID 21528456 DOI: 10.1007/978-1-61779-046-1_14  1
2011 Jaramillo M, Gomez MA, Larsson O, Shio MT, Topisirovic I, Contreras I, Luxenburg R, Rosenfeld A, Colina R, McMaster RW, Olivier M, Costa-Mattioli M, Sonenberg N. Leishmania repression of host translation through mTOR cleavage is required for parasite survival and infection. Cell Host & Microbe. 9: 331-41. PMID 21501832 DOI: 10.1016/j.chom.2011.03.008  1
2011 Frank F, Fabian MR, Stepinski J, Jemielity J, Darzynkiewicz E, Sonenberg N, Nagar B. Structural analysis of 5'-mRNA-cap interactions with the human AGO2 MID domain. Embo Reports. 12: 415-20. PMID 21475248 DOI: 10.1038/embor.2011.48  1
2011 Parsyan A, Svitkin Y, Shahbazian D, Gkogkas C, Lasko P, Merrick WC, Sonenberg N. mRNA helicases: the tacticians of translational control. Nature Reviews. Molecular Cell Biology. 12: 235-45. PMID 21427765 DOI: 10.1038/nrm3083  1
2011 Larsson O, Sonenberg N, Nadon R. anota: Analysis of differential translation in genome-wide studies. Bioinformatics (Oxford, England). 27: 1440-1. PMID 21422072 DOI: 10.1093/bioinformatics/btr146  1
2011 Konicek BW, Stephens JR, McNulty AM, Robichaud N, Peery RB, Dumstorf CA, Dowless MS, Iversen PW, Parsons S, Ellis KE, McCann DJ, Pelletier J, Furic L, Yingling JM, Stancato LF, ... Sonenberg N, et al. Therapeutic inhibition of MAP kinase interacting kinase blocks eukaryotic initiation factor 4E phosphorylation and suppresses outgrowth of experimental lung metastases. Cancer Research. 71: 1849-57. PMID 21233335 DOI: 10.1158/0008-5472.CAN-10-3298  1
2011 Alvarez-Saavedra M, Antoun G, Yanagiya A, Oliva-Hernandez R, Cornejo-Palma D, Perez-Iratxeta C, Sonenberg N, Cheng HY. miRNA-132 orchestrates chromatin remodeling and translational control of the circadian clock. Human Molecular Genetics. 20: 731-51. PMID 21118894 DOI: 10.1093/hmg/ddq519  1
2010 Larsson O, Sonenberg N, Nadon R. Identification of differential translation in genome wide studies. Proceedings of the National Academy of Sciences of the United States of America. 107: 21487-92. PMID 21115840 DOI: 10.1073/pnas.1006821107  1
2010 Wu E, Thivierge C, Flamand M, Mathonnet G, Vashisht AA, Wohlschlegel J, Fabian MR, Sonenberg N, Duchaine TF. Pervasive and cooperative deadenylation of 3'UTRs by embryonic microRNA families. Molecular Cell. 40: 558-70. PMID 21095586 DOI: 10.1016/j.molcel.2010.11.003  1
2010 Dumstorf CA, Konicek BW, McNulty AM, Parsons SH, Furic L, Sonenberg N, Graff JR. Modulation of 4E-BP1 function as a critical determinant of enzastaurin-induced apoptosis. Molecular Cancer Therapeutics. 9: 3158-63. PMID 20971826 DOI: 10.1158/1535-7163.MCT-10-0413  1
2010 Shahbazian D, Parsyan A, Petroulakis E, Hershey J, Sonenberg N. eIF4B controls survival and proliferation and is regulated by proto-oncogenic signaling pathways. Cell Cycle (Georgetown, Tex.). 9: 4106-9. PMID 20948310 DOI: 10.4161/cc.9.20.13630  1
2010 Yanagiya A, Delbes G, Svitkin YV, Robaire B, Sonenberg N. The poly(A)-binding protein partner Paip2a controls translation during late spermiogenesis in mice. The Journal of Clinical Investigation. 120: 3389-400. PMID 20739757 DOI: 10.1172/JCI43350  1
2010 Topisirovic I, Sonenberg N. 4E-BPs at the crossroads of oncogenic MAPK and AKT signaling. Pigment Cell & Melanoma Research. 23: 585-6. PMID 20704686 DOI: 10.1111/j.1755-148X.2010.00749.x  1
2010 Gkogkas C, Sonenberg N, Costa-Mattioli M. Translational control mechanisms in long-lasting synaptic plasticity and memory. The Journal of Biological Chemistry. 285: 31913-7. PMID 20693284 DOI: 10.1074/jbc.R110.154476  1
2010 Furic L, Rong L, Larsson O, Koumakpayi IH, Yoshida K, Brueschke A, Petroulakis E, Robichaud N, Pollak M, Gaboury LA, Pandolfi PP, Saad F, Sonenberg N. eIF4E phosphorylation promotes tumorigenesis and is associated with prostate cancer progression. Proceedings of the National Academy of Sciences of the United States of America. 107: 14134-9. PMID 20679199 DOI: 10.1073/pnas.1005320107  1
2010 Zhang D, Contu R, Latronico MV, Zhang J, Zhang JL, Rizzi R, Catalucci D, Miyamoto S, Huang K, Ceci M, Gu Y, Dalton ND, Peterson KL, Guan KL, Brown JH, ... ... Sonenberg N, et al. MTORC1 regulates cardiac function and myocyte survival through 4E-BP1 inhibition in mice. The Journal of Clinical Investigation. 120: 2805-16. PMID 20644257 DOI: 10.1172/JCI43008  1
2010 Schrufer TL, Antonetti DA, Sonenberg N, Kimball SR, Gardner TW, Jefferson LS. Ablation of 4E-BP1/2 prevents hyperglycemia-mediated induction of VEGF expression in the rodent retina and in Muller cells in culture. Diabetes. 59: 2107-16. PMID 20547975 DOI: 10.2337/db10-0148  1
2010 Fabian MR, Sonenberg N, Filipowicz W. Regulation of mRNA translation and stability by microRNAs. Annual Review of Biochemistry. 79: 351-79. PMID 20533884 DOI: 10.1146/annurev-biochem-060308-103103  1
2010 Dowling RJ, Topisirovic I, Alain T, Bidinosti M, Fonseca BD, Petroulakis E, Wang X, Larsson O, Selvaraj A, Liu Y, Kozma SC, Thomas G, Sonenberg N. mTORC1-mediated cell proliferation, but not cell growth, controlled by the 4E-BPs. Science (New York, N.Y.). 328: 1172-6. PMID 20508131 DOI: 10.1126/science.1187532  1
2010 Frank F, Sonenberg N, Nagar B. Structural basis for 5'-nucleotide base-specific recognition of guide RNA by human AGO2. Nature. 465: 818-22. PMID 20505670 DOI: 10.1038/nature09039  1
2010 Carnevalli LS, Masuda K, Frigerio F, Le Bacquer O, Um SH, Gandin V, Topisirovic I, Sonenberg N, Thomas G, Kozma SC. S6K1 plays a critical role in early adipocyte differentiation. Developmental Cell. 18: 763-74. PMID 20493810 DOI: 10.1016/j.devcel.2010.02.018  1
2010 Livingstone M, Atas E, Meller A, Sonenberg N. Mechanisms governing the control of mRNA translation. Physical Biology. 7: 021001. PMID 20463379 DOI: 10.1088/1478-3975/7/2/021001  1
2010 Sadovski O, Jaikaran AS, Samanta S, Fabian MR, Dowling RJ, Sonenberg N, Woolley GA. A collection of caged compounds for probing roles of local translation in neurobiology. Bioorganic & Medicinal Chemistry. 18: 7746-52. PMID 20427189 DOI: 10.1016/j.bmc.2010.04.005  1
2010 Bidinosti M, Martineau Y, Frank F, Sonenberg N. Repair of isoaspartate formation modulates the interaction of deamidated 4E-BP2 with mTORC1 in brain. The Journal of Biological Chemistry. 285: 19402-8. PMID 20424163 DOI: 10.1074/jbc.M110.120774  1
2010 Deleavey GF, Watts JK, Alain T, Robert F, Kalota A, Aishwarya V, Pelletier J, Gewirtz AM, Sonenberg N, Damha MJ. Synergistic effects between analogs of DNA and RNA improve the potency of siRNA-mediated gene silencing. Nucleic Acids Research. 38: 4547-57. PMID 20413581 DOI: 10.1093/nar/gkq181  1
2010 Bidinosti M, Ran I, Sanchez-Carbente MR, Martineau Y, Gingras AC, Gkogkas C, Raught B, Bramham CR, Sossin WS, Costa-Mattioli M, DesGroseillers L, Lacaille JC, Sonenberg N. Postnatal deamidation of 4E-BP2 in brain enhances its association with raptor and alters kinetics of excitatory synaptic transmission. Molecular Cell. 37: 797-808. PMID 20347422 DOI: 10.1016/j.molcel.2010.02.022  1
2010 Topisirovic I, Sonenberg N. Cell biology. Burn out or fade away? Science (New York, N.Y.). 327: 1210-1. PMID 20203039 DOI: 10.1126/science.1187497  1
2010 Chakravarti N, Kadara H, Yoon DJ, Shay JW, Myers JN, Lotan D, Sonenberg N, Lotan R. Differential inhibition of protein translation machinery by curcumin in normal, immortalized, and malignant oral epithelial cells. Cancer Prevention Research (Philadelphia, Pa.). 3: 331-8. PMID 20145189 DOI: 10.1158/1940-6207.CAPR-09-0076  1
2010 Nakamura T, Furuhashi M, Li P, Cao H, Tuncman G, Sonenberg N, Gorgun CZ, Hotamisligil GS. Double-stranded RNA-dependent protein kinase links pathogen sensing with stress and metabolic homeostasis. Cell. 140: 338-48. PMID 20144759 DOI: 10.1016/j.cell.2010.01.001  1
2010 Jinek M, Fabian MR, Coyle SM, Sonenberg N, Doudna JA. Structural insights into the human GW182-PABC interaction in microRNA-mediated deadenylation. Nature Structural & Molecular Biology. 17: 238-40. PMID 20098421 DOI: 10.1038/nsmb.1768  0.48
2010 Shahbazian D, Parsyan A, Petroulakis E, Topisirovic I, Martineau Y, Gibbs BF, Svitkin Y, Sonenberg N. Control of cell survival and proliferation by mammalian eukaryotic initiation factor 4B. Molecular and Cellular Biology. 30: 1478-85. PMID 20086100 DOI: 10.1128/MCB.01218-09  1
2010 Alain T, Lun X, Martineau Y, Sean P, Pulendran B, Petroulakis E, Zemp FJ, Lemay CG, Roy D, Bell JC, Thomas G, Kozma SC, Forsyth PA, Costa-Mattioli M, Sonenberg N. Vesicular stomatitis virus oncolysis is potentiated by impairing mTORC1-dependent type I IFN production. Proceedings of the National Academy of Sciences of the United States of America. 107: 1576-81. PMID 20080710 DOI: 10.1073/pnas.0912344107  1
2010 Frank F, Virgili G, Sonenberg N, Nagar B. Crystallization and preliminary X-ray diffraction analysis of the MIF4G domain of DAP5. Acta Crystallographica. Section F, Structural Biology and Crystallization Communications. 66: 15-9. PMID 20057060 DOI: 10.1107/S1744309109044315  1
2010 Sukarieh R, Sonenberg N, Pelletier J. Nuclear assortment of eIF4E coincides with shut-off of host protein synthesis upon poliovirus infection. The Journal of General Virology. 91: 1224-8. PMID 20053821 DOI: 10.1099/vir.0.018069-0  1
2010 Dowling RJ, Topisirovic I, Fonseca BD, Sonenberg N. Dissecting the role of mTOR: lessons from mTOR inhibitors. Biochimica Et Biophysica Acta. 1804: 433-9. PMID 20005306 DOI: 10.1016/j.bbapap.2009.12.001  1
2010 Khalid S, Hwang D, Babichev Y, Kolli R, Altamentova S, Koren S, Goodwin PJ, Ennis M, Pollak M, Sonenberg N, Fantus IG. Evidence for a tumor promoting effect of high-fat diet independent of insulin resistance in HER2/Neu mammary carcinogenesis. Breast Cancer Research and Treatment. 122: 647-59. PMID 19851863 DOI: 10.1007/s10549-009-0586-8  1
2010 Fabian MR, Sundermeier TR, Sonenberg N. Understanding how miRNAs post-transcriptionally regulate gene expression. Progress in Molecular and Subcellular Biology. 50: 1-20. PMID 19841878 DOI: 10.1007/978-3-642-03103-8_1  1
2010 Zhang D, Contu R, Latronico MVG, Zhang J, Rizzi R, Catalucci D, Miyamoto S, Huang K, Ceci M, Gu Y, Dalton ND, Peterson KL, Guan KL, Brown JH, Chen J, ... Sonenberg N, et al. MTORC1 regulates cardiac function and myocyte survival through 4E-BP1 inhibition in mice (Journal of Clinical Investigation (2010) 120, 8, (2805-2816) DOI: 10.1172/JCI43008) Journal of Clinical Investigation. 120: 3735. DOI: 10.1172/JCI43008C1  1
2010 Dowling RJO, Sonenberg N. Signaling pathways that mediate translational control of ribosome recruitment to mRNA Handbook of Cell Signaling, 2/E. 3: 2335-2341. DOI: 10.1016/B978-0-12-374145-5.00281-3  1
2009 Costa-Mattioli M, Sonenberg N, Richter JD. Translational regulatory mechanisms in synaptic plasticity and memory storage. Progress in Molecular Biology and Translational Science. 90: 293-311. PMID 20374745 DOI: 10.1016/S1877-1173(09)90008-4  1
2009 Fukao A, Sasano Y, Imataka H, Inoue K, Sakamoto H, Sonenberg N, Thoma C, Fujiwara T. The ELAV protein HuD stimulates cap-dependent translation in a Poly(A)- and eIF4A-dependent manner. Molecular Cell. 36: 1007-17. PMID 20064466 DOI: 10.1016/j.molcel.2009.11.013  1
2009 Livingstone M, Larsson O, Sukarieh R, Pelletier J, Sonenberg N. A chemical genetic screen for mTOR pathway inhibitors based on 4E-BP-dependent nuclear accumulation of eIF4E. Chemistry & Biology. 16: 1240-9. PMID 20064434 DOI: 10.1016/j.chembiol.2009.11.010  1
2009 Parsyan A, Shahbazian D, Martineau Y, Petroulakis E, Alain T, Larsson O, Mathonnet G, Tettweiler G, Hellen CU, Pestova TV, Svitkin YV, Sonenberg N. The helicase protein DHX29 promotes translation initiation, cell proliferation, and tumorigenesis. Proceedings of the National Academy of Sciences of the United States of America. 106: 22217-22. PMID 20018725 DOI: 10.1073/pnas.0909773106  1
2009 Petroulakis E, Parsyan A, Dowling RJ, LeBacquer O, Martineau Y, Bidinosti M, Larsson O, Alain T, Rong L, Mamane Y, Paquet M, Furic L, Topisirovic I, Shahbazian D, Livingstone M, ... ... Sonenberg N, et al. p53-dependent translational control of senescence and transformation via 4E-BPs. Cancer Cell. 16: 439-46. PMID 19878875 DOI: 10.1016/j.ccr.2009.09.025  1
2009 Kanaan AS, Frank F, Maedler-Kron C, Verma K, Sonenberg N, Nagar B. Crystallization and preliminary X-ray diffraction analysis of the middle domain of Paip1. Acta Crystallographica. Section F, Structural Biology and Crystallization Communications. 65: 1060-4. PMID 19851022 DOI: 10.1107/S1744309109036513  1
2009 Panja D, Dagyte G, Bidinosti M, Wibrand K, Kristiansen AM, Sonenberg N, Bramham CR. Novel translational control in Arc-dependent long term potentiation consolidation in vivo. The Journal of Biological Chemistry. 284: 31498-511. PMID 19755425 DOI: 10.1074/jbc.M109.056077  1
2009 Fabian MR, Mathonnet G, Sundermeier T, Mathys H, Zipprich JT, Svitkin YV, Rivas F, Jinek M, Wohlschlegel J, Doudna JA, Chen CY, Shyu AB, Yates JR, Hannon GJ, Filipowicz W, ... ... Sonenberg N, et al. Mammalian miRNA RISC recruits CAF1 and PABP to affect PABP-dependent deadenylation. Molecular Cell. 35: 868-80. PMID 19716330 DOI: 10.1016/j.molcel.2009.08.004  1
2009 Thuaud F, Bernard Y, Türkeri G, Dirr R, Aubert G, Cresteil T, Baguet A, Tomasetto C, Svitkin Y, Sonenberg N, Nebigil CG, Désaubry L. Synthetic analogue of rocaglaol displays a potent and selective cytotoxicity in cancer cells: involvement of apoptosis inducing factor and caspase-12. Journal of Medicinal Chemistry. 52: 5176-87. PMID 19655762 DOI: 10.1021/jm900365v  1
2009 Dowling RJ, Pollak M, Sonenberg N. Current status and challenges associated with targeting mTOR for cancer therapy. Biodrugs : Clinical Immunotherapeutics, Biopharmaceuticals and Gene Therapy. 23: 77-91. PMID 19489650 DOI: 10.2165/00063030-200923020-00002  1
2009 Ran I, Laplante I, Bourgeois C, Pépin J, Lacaille P, Costa-Mattioli M, Pelletier J, Sonenberg N, Lacaille JC. Persistent transcription- and translation-dependent long-term potentiation induced by mGluR1 in hippocampal interneurons. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 29: 5605-15. PMID 19403827 DOI: 10.1523/JNEUROSCI.5355-08.2009  1
2009 Sukarieh R, Sonenberg N, Pelletier J. The eIF4E-binding proteins are modifiers of cytoplasmic eIF4E relocalization during the heat shock response. American Journal of Physiology. Cell Physiology. 296: C1207-17. PMID 19244480 DOI: 10.1152/ajpcell.00511.2008  1
2009 Sonenberg N, Hinnebusch AG. Regulation of translation initiation in eukaryotes: mechanisms and biological targets. Cell. 136: 731-45. PMID 19239892 DOI: 10.1016/j.cell.2009.01.042  1
2009 Furic L, Livingstone M, Dowling RJ, Sonenberg N. Targeting mTOR-dependent tumours with specific inhibitors: a model for personalized medicine based on molecular diagnoses. Current Oncology (Toronto, Ont.). 16: 59-61. PMID 19229373  1
2009 Marintchev A, Edmonds KA, Marintcheva B, Hendrickson E, Oberer M, Suzuki C, Herdy B, Sonenberg N, Wagner G. Topology and regulation of the human eIF4A/4G/4H helicase complex in translation initiation. Cell. 136: 447-60. PMID 19203580 DOI: 10.1016/j.cell.2009.01.014  1
2009 Olson KE, Booth GC, Poulin F, Sonenberg N, Beretta L. Impaired myelopoiesis in mice lacking the repressors of translation initiation, 4E-BP1 and 4E-BP2. Immunology. 128: e376-84. PMID 19175792 DOI: 10.1111/j.1365-2567.2008.02981.x  1
2009 Costa-Mattioli M, Sossin WS, Klann E, Sonenberg N. Translational control of long-lasting synaptic plasticity and memory. Neuron. 61: 10-26. PMID 19146809 DOI: 10.1016/j.neuron.2008.10.055  1
2009 Yanagiya A, Svitkin YV, Shibata S, Mikami S, Imataka H, Sonenberg N. Requirement of RNA binding of mammalian eukaryotic translation initiation factor 4GI (eIF4GI) for efficient interaction of eIF4E with the mRNA cap. Molecular and Cellular Biology. 29: 1661-9. PMID 19114555 DOI: 10.1128/MCB.01187-08  1
2009 Svitkin YV, Evdokimova VM, Brasey A, Pestova TV, Fantus D, Yanagiya A, Imataka H, Skabkin MA, Ovchinnikov LP, Merrick WC, Sonenberg N. General RNA-binding proteins have a function in poly(A)-binding protein-dependent translation. The Embo Journal. 28: 58-68. PMID 19078965 DOI: 10.1038/emboj.2008.259  1
2009 Brenet F, Socci ND, Sonenberg N, Holland EC. Akt phosphorylation of La regulates specific mRNA translation in glial progenitors. Oncogene. 28: 128-39. PMID 18836485 DOI: 10.1038/onc.2008.376  1
2009 Zakikhani M, Dowling RJO, Sonenberg N, Pollak MN. The effects of adiponectin and metformin on prostate and colon neoplasia involve activation 08 AMP-activated protein kinase (Cancer Prevention Research (2008) 1, (369-375)) Cancer Prevention Research. 2: 95. DOI: 10.1158/1940-6207.CAPR-2-1-COR  1
2008 Zakikhani M, Dowling RJ, Sonenberg N, Pollak MN. The effects of adiponectin and metformin on prostate and colon neoplasia involve activation of AMP-activated protein kinase. Cancer Prevention Research (Philadelphia, Pa.). 1: 369-75. PMID 19138981 DOI: 10.1158/1940-6207.CAPR-08-0081  1
2008 Napoli I, Mercaldo V, Boyl PP, Eleuteri B, Zalfa F, De Rubeis S, Di Marino D, Mohr E, Massimi M, Falconi M, Witke W, Costa-Mattioli M, Sonenberg N, Achsel T, Bagni C. The fragile X syndrome protein represses activity-dependent translation through CYFIP1, a new 4E-BP. Cell. 134: 1042-54. PMID 18805096 DOI: 10.1016/j.cell.2008.07.031  1
2008 Costa-Mattioli M, Sonenberg N. RAPping production of type I interferon in pDCs through mTOR. Nature Immunology. 9: 1097-9. PMID 18800159 DOI: 10.1038/ni1008-1097  1
2008 Martineau Y, Derry MC, Wang X, Yanagiya A, Berlanga JJ, Shyu AB, Imataka H, Gehring K, Sonenberg N. Poly(A)-binding protein-interacting protein 1 binds to eukaryotic translation initiation factor 3 to stimulate translation. Molecular and Cellular Biology. 28: 6658-67. PMID 18725400 DOI: 10.1128/MCB.00738-08  1
2008 Aizer A, Brody Y, Ler LW, Sonenberg N, Singer RH, Shav-Tal Y. The dynamics of mammalian P body transport, assembly, and disassembly in vivo. Molecular Biology of the Cell. 19: 4154-66. PMID 18653466 DOI: 10.1091/mbc.E08-05-0513  1
2008 Rong L, Livingstone M, Sukarieh R, Petroulakis E, Gingras AC, Crosby K, Smith B, Polakiewicz RD, Pelletier J, Ferraiuolo MA, Sonenberg N. Control of eIF4E cellular localization by eIF4E-binding proteins, 4E-BPs. Rna (New York, N.Y.). 14: 1318-27. PMID 18515545 DOI: 10.1261/rna.950608  1
2008 Sonenberg N. eIF4E, the mRNA cap-binding protein: from basic discovery to translational research. Biochemistry and Cell Biology = Biochimie Et Biologie Cellulaire. 86: 178-83. PMID 18443631 DOI: 10.1139/O08-034  1
2008 Oliere S, Arguello M, Mesplede T, Tumilasci V, Nakhaei P, Stojdl D, Sonenberg N, Bell J, Hiscott J. Vesicular stomatitis virus oncolysis of T lymphocytes requires cell cycle entry and translation initiation. Journal of Virology. 82: 5735-49. PMID 18417567 DOI: 10.1128/JVI.02601-07  1
2008 Costa-Mattioli M, Sonenberg N. Translational control of gene expression: a molecular switch for memory storage. Progress in Brain Research. 169: 81-95. PMID 18394469 DOI: 10.1016/S0079-6123(07)00005-2  1
2008 Yamaguchi S, Ishihara H, Yamada T, Tamura A, Usui M, Tominaga R, Munakata Y, Satake C, Katagiri H, Tashiro F, Aburatani H, Tsukiyama-Kohara K, Miyazaki J, Sonenberg N, Oka Y. ATF4-mediated induction of 4E-BP1 contributes to pancreatic beta cell survival under endoplasmic reticulum stress. Cell Metabolism. 7: 269-76. PMID 18316032 DOI: 10.1016/j.cmet.2008.01.008  1
2008 Colina R, Costa-Mattioli M, Dowling RJ, Jaramillo M, Tai LH, Breitbach CJ, Martineau Y, Larsson O, Rong L, Svitkin YV, Makrigiannis AP, Bell JC, Sonenberg N. Translational control of the innate immune response through IRF-7. Nature. 452: 323-8. PMID 18272964 DOI: 10.1038/nature06730  1
2008 Filipowicz W, Bhattacharyya SN, Sonenberg N. Mechanisms of post-transcriptional regulation by microRNAs: are the answers in sight? Nature Reviews. Genetics. 9: 102-14. PMID 18197166 DOI: 10.1038/nrg2290  1
2007 Sonenberg N, Hinnebusch AG. New modes of translational control in development, behavior, and disease. Molecular Cell. 28: 721-9. PMID 18082597 DOI: 10.1016/j.molcel.2007.11.018  1
2007 Dowling RJ, Zakikhani M, Fantus IG, Pollak M, Sonenberg N. Metformin inhibits mammalian target of rapamycin-dependent translation initiation in breast cancer cells. Cancer Research. 67: 10804-12. PMID 18006825 DOI: 10.1158/0008-5472.CAN-07-2310  1
2007 Lee CH, Inoki K, Karbowniczek M, Petroulakis E, Sonenberg N, Henske EP, Guan KL. Constitutive mTOR activation in TSC mutants sensitizes cells to energy starvation and genomic damage via p53. The Embo Journal. 26: 4812-23. PMID 17962806 DOI: 10.1038/sj.emboj.7601900  1
2007 Svitkin YV, Costa-Mattioli M, Herdy B, Perreault S, Sonenberg N. Stimulation of picornavirus replication by the poly(A) tail in a cell-free extract is largely independent of the poly(A) binding protein (PABP). Rna (New York, N.Y.). 13: 2330-40. PMID 17942745 DOI: 10.1261/rna.606407  1
2007 Svitkin YV, Sonenberg N. A highly efficient and robust in vitro translation system for expression of picornavirus and hepatitis C virus RNA genomes. Methods in Enzymology. 429: 53-82. PMID 17913619 DOI: 10.1016/S0076-6879(07)29004-4  1
2007 Burgui I, Yángüez E, Sonenberg N, Nieto A. Influenza virus mRNA translation revisited: is the eIF4E cap-binding factor required for viral mRNA translation? Journal of Virology. 81: 12427-38. PMID 17855553 DOI: 10.1128/JVI.01105-07  1
2007 Mathonnet G, Fabian MR, Svitkin YV, Parsyan A, Huck L, Murata T, Biffo S, Merrick WC, Darzynkiewicz E, Pillai RS, Filipowicz W, Duchaine TF, Sonenberg N. MicroRNA inhibition of translation initiation in vitro by targeting the cap-binding complex eIF4F. Science (New York, N.Y.). 317: 1764-7. PMID 17656684 DOI: 10.1126/science.1146067  1
2007 Gelinas JN, Banko JL, Hou L, Sonenberg N, Weeber EJ, Klann E, Nguyen PV. ERK and mTOR signaling couple beta-adrenergic receptors to translation initiation machinery to gate induction of protein synthesis-dependent long-term potentiation. The Journal of Biological Chemistry. 282: 27527-35. PMID 17635924 DOI: 10.1074/jbc.M701077200  1
2007 Masutani M, Sonenberg N, Yokoyama S, Imataka H. Reconstitution reveals the functional core of mammalian eIF3. The Embo Journal. 26: 3373-83. PMID 17581632 DOI: 10.1038/sj.emboj.7601765  1
2007 Hu J, Straub J, Xiao D, Singh SV, Yang HS, Sonenberg N, Vatsyayan J. Phenethyl isothiocyanate, a cancer chemopreventive constituent of cruciferous vegetables, inhibits cap-dependent translation by regulating the level and phosphorylation of 4E-BP1. Cancer Research. 67: 3569-73. PMID 17440067 DOI: 10.1158/0008-5472.CAN-07-0392  1
2007 Costa-Mattioli M, Gobert D, Stern E, Gamache K, Colina R, Cuello C, Sossin W, Kaufman R, Pelletier J, Rosenblum K, Krnjević K, Lacaille JC, Nader K, Sonenberg N. eIF2alpha phosphorylation bidirectionally regulates the switch from short- to long-term synaptic plasticity and memory. Cell. 129: 195-206. PMID 17418795 DOI: 10.1016/j.cell.2007.01.050  1
2007 Petroulakis E, Mamane Y, Le Bacquer O, Shahbazian D, Sonenberg N. mTOR signaling: implications for cancer and anticancer therapy. British Journal of Cancer. 96: R11-5. PMID 17393579  0.36
2007 Zuberek J, Kubacka D, Jablonowska A, Jemielity J, Stepinski J, Sonenberg N, Darzynkiewicz E. Weak binding affinity of human 4EHP for mRNA cap analogs. Rna (New York, N.Y.). 13: 691-7. PMID 17369309 DOI: 10.1261/rna.453107  1
2007 Wilker EW, van Vugt MA, Artim SA, Huang PH, Petersen CP, Reinhardt HC, Feng Y, Sharp PA, Sonenberg N, White FM, Yaffe MB. 14-3-3sigma controls mitotic translation to facilitate cytokinesis. Nature. 446: 329-32. PMID 17361185 DOI: 10.1038/nature05584  1
2007 Roux PP, Shahbazian D, Vu H, Holz MK, Cohen MS, Taunton J, Sonenberg N, Blenis J. RAS/ERK signaling promotes site-specific ribosomal protein S6 phosphorylation via RSK and stimulates cap-dependent translation. The Journal of Biological Chemistry. 282: 14056-64. PMID 17360704 DOI: 10.1074/jbc.M700906200  1
2007 Mamane Y, Petroulakis E, Martineau Y, Sato TA, Larsson O, Rajasekhar VK, Sonenberg N. Epigenetic activation of a subset of mRNAs by eIF4E explains its effects on cell proliferation. Plos One. 2: e242. PMID 17311107 DOI: 10.1371/journal.pone.0000242  1
2007 Lasko P, Sonenberg N. Coordinated transcriptional and translational control in metabolic homeostasis in flies. Genes & Development. 21: 235-7. PMID 17289913 DOI: 10.1101/gad.1524707  1
2007 Le Bacquer O, Petroulakis E, Paglialunga S, Poulin F, Richard D, Cianflone K, Sonenberg N. Elevated sensitivity to diet-induced obesity and insulin resistance in mice lacking 4E-BP1 and 4E-BP2. The Journal of Clinical Investigation. 117: 387-96. PMID 17273556 DOI: 10.1172/JCI29528  1
2007 Kaur S, Lal L, Sassano A, Majchrzak-Kita B, Srikanth M, Baker DP, Petroulakis E, Hay N, Sonenberg N, Fish EN, Platanias LC. Regulatory effects of mammalian target of rapamycin-activated pathways in type I and II interferon signaling. The Journal of Biological Chemistry. 282: 1757-68. PMID 17114181 DOI: 10.1074/jbc.M607365200  1
2007 Banko JL, Merhav M, Stern E, Sonenberg N, Rosenblum K, Klann E. Behavioral alterations in mice lacking the translation repressor 4E-BP2. Neurobiology of Learning and Memory. 87: 248-56. PMID 17029989 DOI: 10.1016/j.nlm.2006.08.012  1
2006 Costa-Mattioli M, Sonenberg N. Translational control of long-term synaptic plasticity and memory storage by eIF2alpha. Critical Reviews in Neurobiology. 18: 187-95. PMID 17725521  1
2006 Khanam T, Muddashetty RS, Kahvejian A, Sonenberg N, Brosius J. Poly(A)-binding protein binds to A-rich sequences via RNA-binding domains 1+2 and 3+4. Rna Biology. 3: 170-7. PMID 17387282  1
2006 Derry MC, Yanagiya A, Martineau Y, Sonenberg N. Regulation of poly(A)-binding protein through PABP-interacting proteins. Cold Spring Harbor Symposia On Quantitative Biology. 71: 537-43. PMID 17381337 DOI: 10.1101/sqb.2006.71.061  1
2006 Kanhema T, Dagestad G, Panja D, Tiron A, Messaoudi E, Håvik B, Ying SW, Nairn AC, Sonenberg N, Bramham CR. Dual regulation of translation initiation and peptide chain elongation during BDNF-induced LTP in vivo: evidence for compartment-specific translation control. Journal of Neurochemistry. 99: 1328-37. PMID 17064361 DOI: 10.1111/j.1471-4159.2006.04158.x  1
2006 Zakikhani M, Dowling R, Fantus IG, Sonenberg N, Pollak M. Metformin is an AMP kinase-dependent growth inhibitor for breast cancer cells. Cancer Research. 66: 10269-73. PMID 17062558 DOI: 10.1158/0008-5472.CAN-06-1500  1
2006 Cho PF, Gamberi C, Cho-Park YA, Cho-Park IB, Lasko P, Sonenberg N. Cap-dependent translational inhibition establishes two opposing morphogen gradients in Drosophila embryos. Current Biology : Cb. 16: 2035-41. PMID 17055983 DOI: 10.1016/j.cub.2006.08.093  1
2006 Sonenberg N, Pause A. Signal transduction. Protein synthesis and oncogenesis meet again. Science (New York, N.Y.). 314: 428-9. PMID 17053135 DOI: 10.1126/science.1134031  1
2006 Mamane Y, Petroulakis E, LeBacquer O, Sonenberg N. mTOR, translation initiation and cancer. Oncogene. 25: 6416-22. PMID 17041626 DOI: 10.1038/sj.onc.1209888  1
2006 Miyakawa S, Oguro A, Ohtsu T, Imataka H, Sonenberg N, Nakamura Y. RNA aptamers to mammalian initiation factor 4G inhibit cap-dependent translation by blocking the formation of initiation factor complexes. Rna (New York, N.Y.). 12: 1825-34. PMID 16940549 DOI: 10.1261/rna.2169406  1
2006 Svitkin YV, Sonenberg N. [Translational control by the poly(A) binding protein: a check for mRNA integrity]. Molekuliarnaia Biologiia. 40: 684-93. PMID 16913227  1
2006 Berlanga JJ, Baass A, Sonenberg N. Regulation of poly(A) binding protein function in translation: Characterization of the Paip2 homolog, Paip2B. Rna (New York, N.Y.). 12: 1556-68. PMID 16804161 DOI: 10.1261/rna.106506  1
2006 Karim MM, Svitkin YV, Kahvejian A, De Crescenzo G, Costa-Mattioli M, Sonenberg N. A mechanism of translational repression by competition of Paip2 with eIF4G for poly(A) binding protein (PABP) binding. Proceedings of the National Academy of Sciences of the United States of America. 103: 9494-9. PMID 16772376 DOI: 10.1073/pnas.0603701103  1
2006 Shahbazian D, Roux PP, Mieulet V, Cohen MS, Raught B, Taunton J, Hershey JW, Blenis J, Pende M, Sonenberg N. The mTOR/PI3K and MAPK pathways converge on eIF4B to control its phosphorylation and activity. The Embo Journal. 25: 2781-91. PMID 16763566 DOI: 10.1038/sj.emboj.7601166  1
2006 Bellsolell L, Cho-Park PF, Poulin F, Sonenberg N, Burley SK. Two structurally atypical HEAT domains in the C-terminal portion of human eIF4G support binding to eIF4A and Mnk1. Structure (London, England : 1993). 14: 913-23. PMID 16698552 DOI: 10.1016/j.str.2006.03.012  1
2006 Yoshida M, Yoshida K, Kozlov G, Lim NS, De Crescenzo G, Pang Z, Berlanga JJ, Kahvejian A, Gehring K, Wing SS, Sonenberg N. Poly(A) binding protein (PABP) homeostasis is mediated by the stability of its inhibitor, Paip2. The Embo Journal. 25: 1934-44. PMID 16601676 DOI: 10.1038/sj.emboj.7601079  1
2006 Banko JL, Hou L, Poulin F, Sonenberg N, Klann E. Regulation of eukaryotic initiation factor 4E by converging signaling pathways during metabotropic glutamate receptor-dependent long-term depression. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 26: 2167-73. PMID 16495443 DOI: 10.1523/JNEUROSCI.5196-05.2006  1
2006 Koritzinsky M, Magagnin MG, van den Beucken T, Seigneuric R, Savelkouls K, Dostie J, Pyronnet S, Kaufman RJ, Weppler SA, Voncken JW, Lambin P, Koumenis C, Sonenberg N, Wouters BG. Gene expression during acute and prolonged hypoxia is regulated by distinct mechanisms of translational control. The Embo Journal. 25: 1114-25. PMID 16467844 DOI: 10.1038/sj.emboj.7600998  1
2006 Petroulakis E, Mamane Y, Le Bacquer O, Shahbazian D, Sonenberg N. mTOR signaling: implications for cancer and anticancer therapy. British Journal of Cancer. 94: 195-9. PMID 16404421 DOI: 10.1038/sj.bjc.6602902  1
2006 Evdokimova V, Ruzanov P, Anglesio MS, Sorokin AV, Ovchinnikov LP, Buckley J, Triche TJ, Sonenberg N, Sorensen PH. Akt-mediated YB-1 phosphorylation activates translation of silent mRNA species. Molecular and Cellular Biology. 26: 277-92. PMID 16354698 DOI: 10.1128/MCB.26.1.277-292.2006  1
2006 Mikami S, Masutani M, Sonenberg N, Yokoyama S, Imataka H. An efficient mammalian cell-free translation system supplemented with translation factors. Protein Expression and Purification. 46: 348-57. PMID 16289705 DOI: 10.1016/j.pep.2005.09.021  0.56
2006 Svitkin YV, Sonenberg N. Translational control by the poly(A) binding protein: A check for mRNA integrity Molecular Biology. 40: 611-619. DOI: 10.1134/S0026893306040133  1
2005 Svitkin YV, Herdy B, Costa-Mattioli M, Gingras AC, Raught B, Sonenberg N. Eukaryotic translation initiation factor 4E availability controls the switch between cap-dependent and internal ribosomal entry site-mediated translation. Molecular and Cellular Biology. 25: 10556-65. PMID 16287867 DOI: 10.1128/MCB.25.23.10556-10565.2005  1
2005 Lasko P, Cho P, Poulin F, Sonenberg N. Contrasting mechanisms of regulating translation of specific Drosophila germline mRNAs at the level of 5'-cap structure binding. Biochemical Society Transactions. 33: 1544-6. PMID 16246166 DOI: 10.1042/BST20051544  1
2005 Banko JL, Poulin F, Hou L, DeMaria CT, Sonenberg N, Klann E. The translation repressor 4E-BP2 is critical for eIF4F complex formation, synaptic plasticity, and memory in the hippocampus. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 25: 9581-90. PMID 16237163 DOI: 10.1523/JNEUROSCI.2423-05.2005  1
2005 Ferraiuolo MA, Basak S, Dostie J, Murray EL, Schoenberg DR, Sonenberg N. A role for the eIF4E-binding protein 4E-T in P-body formation and mRNA decay. The Journal of Cell Biology. 170: 913-24. PMID 16157702 DOI: 10.1083/jcb.200504039  1
2005 Costa-Mattioli M, Gobert D, Harding H, Herdy B, Azzi M, Bruno M, Bidinosti M, Ben Mamou C, Marcinkiewicz E, Yoshida M, Imataka H, Cuello AC, Seidah N, Sossin W, Lacaille JC, ... ... Sonenberg N, et al. Translational control of hippocampal synaptic plasticity and memory by the eIF2alpha kinase GCN2. Nature. 436: 1166-73. PMID 16121183 DOI: 10.1038/nature03897  1
2005 Gingras AC, Caballero M, Zarske M, Sanchez A, Hazbun TR, Fields S, Sonenberg N, Hafen E, Raught B, Aebersold R. A novel, evolutionarily conserved protein phosphatase complex involved in cisplatin sensitivity. Molecular & Cellular Proteomics : McP. 4: 1725-40. PMID 16085932 DOI: 10.1074/mcp.M500231-MCP200  1
2005 Tettweiler G, Miron M, Jenkins M, Sonenberg N, Lasko PF. Starvation and oxidative stress resistance in Drosophila are mediated through the eIF4E-binding protein, d4E-BP. Genes & Development. 19: 1840-3. PMID 16055649 DOI: 10.1101/gad.1311805  1
2005 Bordeleau ME, Matthews J, Wojnar JM, Lindqvist L, Novac O, Jankowsky E, Sonenberg N, Northcote P, Teesdale-Spittle P, Pelletier J. Stimulation of mammalian translation initiation factor eIF4A activity by a small molecule inhibitor of eukaryotic translation. Proceedings of the National Academy of Sciences of the United States of America. 102: 10460-5. PMID 16030146 DOI: 10.1073/pnas.0504249102  1
2005 Tyers M, Brown E, Andrews DW, Bergeron JJ, Boone C, Bremner R, Bussey HA, Cross JC, Davies JE, Desjardins M, Dick JE, Dumont DJ, Durocher D, Ellison MJ, Golding GB, ... ... Sonenberg N, et al. Problems with co-funding in Canada. Science (New York, N.Y.). 308: 1867. PMID 15976286 DOI: 10.1126/science.308.5730.1867b  1
2005 Pyronnet S, Pradayrol L, Sonenberg N. Alternative splicing facilitates internal ribosome entry on the ornithine decarboxylase mRNA. Cellular and Molecular Life Sciences : Cmls. 62: 1267-74. PMID 15905964 DOI: 10.1007/s00018-005-5020-8  0.64
2005 Svitkin YV, Pause A, Lopez-Lastra M, Perreault S, Sonenberg N. Complete translation of the hepatitis C virus genome in vitro: membranes play a critical role in the maturation of all virus proteins except for NS3. Journal of Virology. 79: 6868-81. PMID 15890926 DOI: 10.1128/JVI.79.11.6868-6881.2005  1
2005 Cho PF, Poulin F, Cho-Park YA, Cho-Park IB, Chicoine JD, Lasko P, Sonenberg N. A new paradigm for translational control: inhibition via 5'-3' mRNA tethering by Bicoid and the eIF4E cognate 4EHP. Cell. 121: 411-23. PMID 15882623 DOI: 10.1016/j.cell.2005.02.024  1
2005 Ohanna M, Sobering AK, Lapointe T, Lorenzo L, Praud C, Petroulakis E, Sonenberg N, Kelly PA, Sotiropoulos A, Pende M. Atrophy of S6K1(-/-) skeletal muscle cells reveals distinct mTOR effectors for cell cycle and size control. Nature Cell Biology. 7: 286-94. PMID 15723049 DOI: 10.1038/ncb1231  1
2005 Kahvejian A, Svitkin YV, Sukarieh R, M'Boutchou MN, Sonenberg N. Mammalian poly(A)-binding protein is a eukaryotic translation initiation factor, which acts via multiple mechanisms. Genes & Development. 19: 104-13. PMID 15630022 DOI: 10.1101/gad.1262905  1
2005 Malina A, Khan S, Carlson CB, Svitkin Y, Harvey I, Sonenberg N, Beal PA, Pelletier J. Inhibitory properties of nucleic acid-binding ligands on protein synthesis. Febs Letters. 579: 79-89. PMID 15620694 DOI: 10.1016/j.febslet.2004.06.103  1
2004 Deng J, Lu PD, Zhang Y, Scheuner D, Kaufman RJ, Sonenberg N, Harding HP, Ron D. Translational repression mediates activation of nuclear factor kappa B by phosphorylated translation initiation factor 2. Molecular and Cellular Biology. 24: 10161-8. PMID 15542827 DOI: 10.1128/MCB.24.23.10161-10168.2004  1
2004 Baltzis D, Qu LK, Papadopoulou S, Blais JD, Bell JC, Sonenberg N, Koromilas AE. Resistance to vesicular stomatitis virus infection requires a functional cross talk between the eukaryotic translation initiation factor 2alpha kinases PERK and PKR. Journal of Virology. 78: 12747-61. PMID 15542627 DOI: 10.1128/JVI.78.23.12747-12761.2004  1
2004 Shaffer AL, Shapiro-Shelef M, Iwakoshi NN, Lee AH, Qian SB, Zhao H, Yu X, Yang L, Tan BK, Rosenwald A, Hurt EM, Petroulakis E, Sonenberg N, Yewdell JW, Calame K, et al. XBP1, downstream of Blimp-1, expands the secretory apparatus and other organelles, and increases protein synthesis in plasma cell differentiation. Immunity. 21: 81-93. PMID 15345222 DOI: 10.1016/j.immuni.2004.06.010  1
2004 Chang TC, Yamashita A, Chen CY, Yamashita Y, Zhu W, Durdan S, Kahvejian A, Sonenberg N, Shyu AB. UNR, a new partner of poly(A)-binding protein, plays a key role in translationally coupled mRNA turnover mediated by the c-fos major coding-region determinant. Genes & Development. 18: 2010-23. PMID 15314026 DOI: 10.1101/gad.1219104  1
2004 Costa-Mattioli M, Svitkin Y, Sonenberg N. La autoantigen is necessary for optimal function of the poliovirus and hepatitis C virus internal ribosome entry site in vivo and in vitro. Molecular and Cellular Biology. 24: 6861-70. PMID 15254251 DOI: 10.1128/MCB.24.15.6861-6870.2004  1
2004 Orton KC, Ling J, Waskiewicz AJ, Cooper JA, Merrick WC, Korneeva NL, Rhoads RE, Sonenberg N, Traugh JA. Phosphorylation of Mnk1 by caspase-activated Pak2/gamma-PAK inhibits phosphorylation and interaction of eIF4G with Mnk. The Journal of Biological Chemistry. 279: 38649-57. PMID 15234964 DOI: 10.1074/jbc.M407337200  1
2004 Mamane Y, Petroulakis E, Rong L, Yoshida K, Ler LW, Sonenberg N. eIF4E--from translation to transformation. Oncogene. 23: 3172-9. PMID 15094766 DOI: 10.1038/sj.onc.1207549  1
2004 Holland EC, Sonenberg N, Pandolfi PP, Thomas G. Signaling control of mRNA translation in cancer pathogenesis. Oncogene. 23: 3138-44. PMID 15094763 DOI: 10.1038/sj.onc.1207590  1
2004 Yang HS, Cho MH, Zakowicz H, Hegamyer G, Sonenberg N, Colburn NH. A novel function of the MA-3 domains in transformation and translation suppressor Pdcd4 is essential for its binding to eukaryotic translation initiation factor 4A. Molecular and Cellular Biology. 24: 3894-906. PMID 15082783 DOI: 10.1128/MCB.24.9.3894-3906.2004  1
2004 Raught B, Peiretti F, Gingras AC, Livingstone M, Shahbazian D, Mayeur GL, Polakiewicz RD, Sonenberg N, Hershey JW. Phosphorylation of eucaryotic translation initiation factor 4B Ser422 is modulated by S6 kinases. The Embo Journal. 23: 1761-9. PMID 15071500 DOI: 10.1038/sj.emboj.7600193  1
2004 van Breukelen F, Sonenberg N, Martin SL. Seasonal and state-dependent changes of eIF4E and 4E-BP1 during mammalian hibernation: implications for the control of translation during torpor. American Journal of Physiology. Regulatory, Integrative and Comparative Physiology. 287: R349-53. PMID 15059792 DOI: 10.1152/ajpregu.00728.2003  1
2004 Ferraiuolo MA, Lee CS, Ler LW, Hsu JL, Costa-Mattioli M, Luo MJ, Reed R, Sonenberg N. A nuclear translation-like factor eIF4AIII is recruited to the mRNA during splicing and functions in nonsense-mediated decay. Proceedings of the National Academy of Sciences of the United States of America. 101: 4118-23. PMID 15024115 DOI: 10.1073/pnas.0400933101  1
2004 Gradi A, Foeger N, Strong R, Svitkin YV, Sonenberg N, Skern T, Belsham GJ. Cleavage of eukaryotic translation initiation factor 4GII within foot-and-mouth disease virus-infected cells: identification of the L-protease cleavage site in vitro. Journal of Virology. 78: 3271-8. PMID 15016848 DOI: 10.1128/JVI.78.7.3271-3278.2004  1
2004 Svitkin YV, Sonenberg N. An efficient system for cap- and poly(A)-dependent translation in vitro. Methods in Molecular Biology (Clifton, N.J.). 257: 155-70. PMID 14770004 DOI: 10.1385/1-59259-750-5:155  0.56
2004 Donzé O, Deng J, Curran J, Sladek R, Picard D, Sonenberg N. The protein kinase PKR: a molecular clock that sequentially activates survival and death programs. The Embo Journal. 23: 564-71. PMID 14749731 DOI: 10.1038/sj.emboj.7600078  1
2004 Roy G, Miron M, Khaleghpour K, Lasko P, Sonenberg N. The Drosophila poly(A) binding protein-interacting protein, dPaip2, is a novel effector of cell growth. Molecular and Cellular Biology. 24: 1143-54. PMID 14729960 DOI: 10.1128/MCB.24.3.1143-1154.2004  1
2004 Kozlov G, De Crescenzo G, Lim NS, Siddiqui N, Fantus D, Kahvejian A, Trempe JF, Elias D, Ekiel I, Sonenberg N, O'Connor-McCourt M, Gehring K. Structural basis of ligand recognition by PABC, a highly specific peptide-binding domain found in poly(A)-binding protein and a HECT ubiquitin ligase. The Embo Journal. 23: 272-81. PMID 14685257 DOI: 10.1038/sj.emboj.7600048  1
2004 Gingras AC, Raught B, Sonenberg N. mTOR signaling to translation. Current Topics in Microbiology and Immunology. 279: 169-97. PMID 14560958  1
2003 Miron M, Lasko P, Sonenberg N. Signaling from Akt to FRAP/TOR targets both 4E-BP and S6K in Drosophila melanogaster. Molecular and Cellular Biology. 23: 9117-26. PMID 14645523 DOI: 10.1128/MCB.23.24.9117-9126.2003  1
2003 Cormier P, Pyronnet S, Salaün P, Mulner-Lorillon O, Sonenberg N. Cap-dependent translation and control of the cell cycle. Progress in Cell Cycle Research. 5: 469-75. PMID 14593742  0.64
2003 Poulin F, Brueschke A, Sonenberg N. Gene fusion and overlapping reading frames in the mammalian genes for 4E-BP3 and MASK. The Journal of Biological Chemistry. 278: 52290-7. PMID 14557257 DOI: 10.1074/jbc.M310761200  1
2003 Qin H, Raught B, Sonenberg N, Goldstein EG, Edelman AM. Phosphorylation screening identifies translational initiation factor 4GII as an intracellular target of Ca(2+)/calmodulin-dependent protein kinase I. The Journal of Biological Chemistry. 278: 48570-9. PMID 14507913 DOI: 10.1074/jbc.M308781200  1
2003 Svitkin YV, Sonenberg N. Cell-free synthesis of encephalomyocarditis virus. Journal of Virology. 77: 6551-5. PMID 12743313  0.56
2003 Gradi A, Svitkin YV, Sommergruber W, Imataka H, Morino S, Skern T, Sonenberg N. Human rhinovirus 2A proteinase cleavage sites in eukaryotic initiation factors (eIF) 4GI and eIF4GII are different. Journal of Virology. 77: 5026-9. PMID 12663812 DOI: 10.1128/JVI.77.8.5026-5029.2003  1
2003 Oguro A, Ohtsu T, Svitkin YV, Sonenberg N, Nakamura Y. RNA aptamers to initiation factor 4A helicase hinder cap-dependent translation by blocking ATP hydrolysis. Rna (New York, N.Y.). 9: 394-407. PMID 12649492  0.56
2003 Salaün P, Pyronnet S, Morales J, Mulner-Lorillon O, Bellé R, Sonenberg N, Cormier P. eIF4E/4E-BP dissociation and 4E-BP degradation in the first mitotic division of the sea urchin embryo. Developmental Biology. 255: 428-39. PMID 12648502  0.64
2003 Shi Y, Taylor SI, Tan SL, Sonenberg N. When translation meets metabolism: multiple links to diabetes. Endocrine Reviews. 24: 91-101. PMID 12588811 DOI: 10.1210/er.2002-0018  1
2003 Sonenberg N, Dever TE. Eukaryotic translation initiation factors and regulators. Current Opinion in Structural Biology. 13: 56-63. PMID 12581660 DOI: 10.1016/S0959-440X(03)00009-5  1
2003 Zuberek J, Wyslouch-Cieszynska A, Niedzwiecka A, Dadlez M, Stepinski J, Augustyniak W, Gingras AC, Zhang Z, Burley SK, Sonenberg N, Stolarski R, Darzynkiewicz E. Phosphorylation of eIF4E attenuates its interaction with mRNA 5' cap analogs by electrostatic repulsion: intein-mediated protein ligation strategy to obtain phosphorylated protein. Rna (New York, N.Y.). 9: 52-61. PMID 12554876 DOI: 10.1261/rna.2133403  1
2003 Yang HS, Jansen AP, Komar AA, Zheng X, Merrick WC, Costes S, Lockett SJ, Sonenberg N, Colburn NH. The transformation suppressor Pdcd4 is a novel eukaryotic translation initiation factor 4A binding protein that inhibits translation. Molecular and Cellular Biology. 23: 26-37. PMID 12482958 DOI: 10.1128/MCB.23.1.26-37.2003  1
2002 Wang H, Iacoangeli A, Popp S, Muslimov IA, Imataka H, Sonenberg N, Lomakin IB, Tiedge H. Dendritic BC1 RNA: functional role in regulation of translation initiation. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 22: 10232-41. PMID 12451124  1
2002 Tan SL, Pause A, Shi Y, Sonenberg N. Hepatitis C therapeutics: current status and emerging strategies. Nature Reviews. Drug Discovery. 1: 867-81. PMID 12415247 DOI: 10.1038/nrd937  1
2002 Uchida N, Hoshino S, Imataka H, Sonenberg N, Katada T. A novel role of the mammalian GSPT/eRF3 associating with poly(A)-binding protein in Cap/Poly(A)-dependent translation. The Journal of Biological Chemistry. 277: 50286-92. PMID 12381739 DOI: 10.1074/jbc.M203029200  0.56
2002 Deng J, Harding HP, Raught B, Gingras AC, Berlanga JJ, Scheuner D, Kaufman RJ, Ron D, Sonenberg N. Activation of GCN2 in UV-irradiated cells inhibits translation. Current Biology : Cb. 12: 1279-86. PMID 12176355 DOI: 10.1016/S0960-9822(02)01037-0  1
2002 West N, Roy-Engel AM, Imataka H, Sonenberg N, Deininger P. Shared protein components of SINE RNPs. Journal of Molecular Biology. 321: 423-32. PMID 12162956 DOI: 10.1016/S0022-2836(02)00542-9  1
2002 Nikolcheva T, Pyronnet S, Chou SY, Sonenberg N, Song A, Clayberger C, Krensky AM. A translational rheostat for RFLAT-1 regulates RANTES expression in T lymphocytes. The Journal of Clinical Investigation. 110: 119-26. PMID 12093895 DOI: 10.1172/JCI15336  0.64
2002 Niedzwiecka A, Marcotrigiano J, Stepinski J, Jankowska-Anyszka M, Wyslouch-Cieszynska A, Dadlez M, Gingras AC, Mak P, Darzynkiewicz E, Sonenberg N, Burley SK, Stolarski R. Biophysical studies of eIF4E cap-binding protein: recognition of mRNA 5' cap structure and synthetic fragments of eIF4G and 4E-BP1 proteins. Journal of Molecular Biology. 319: 615-35. PMID 12054859 DOI: 10.1016/S0022-2836(02)00328-5  1
2002 Roy G, De Crescenzo G, Khaleghpour K, Kahvejian A, O'Connor-McCourt M, Sonenberg N. Paip1 interacts with poly(A) binding protein through two independent binding motifs. Molecular and Cellular Biology. 22: 3769-82. PMID 11997512 DOI: 10.1128/MCB.22.11.3769-3782.2002  1
2002 Li S, Sonenberg N, Gingras AC, Peterson M, Avdulov S, Polunovsky VA, Bitterman PB. Translational control of cell fate: availability of phosphorylation sites on translational repressor 4E-BP1 governs its proapoptotic potency. Molecular and Cellular Biology. 22: 2853-61. PMID 11909977 DOI: 10.1128/MCB.22.8.2853-2861.2002  1
2002 Lachance PE, Miron M, Raught B, Sonenberg N, Lasko P. Phosphorylation of eukaryotic translation initiation factor 4E is critical for growth. Molecular and Cellular Biology. 22: 1656-63. PMID 11865045 DOI: 10.1128/MCB.22.6.1656-1663.2002  1
2002 Maeshima Y, Sudhakar A, Lively JC, Ueki K, Kharbanda S, Kahn CR, Sonenberg N, Hynes RO, Kalluri R. Tumstatin, an endothelial cell-specific inhibitor of protein synthesis. Science (New York, N.Y.). 295: 140-3. PMID 11778052 DOI: 10.1126/science.1065298  1
2002 Tang SJ, Reis G, Kang H, Gingras AC, Sonenberg N, Schuman EM. A rapamycin-sensitive signaling pathway contributes to long-term synaptic plasticity in the hippocampus. Proceedings of the National Academy of Sciences of the United States of America. 99: 467-72. PMID 11756682 DOI: 10.1073/pnas.012605299  1
2001 Kahvejian A, Roy G, Sonenberg N. The mRNA closed-loop model: the function of PABP and PABP-interacting proteins in mRNA translation. Cold Spring Harbor Symposia On Quantitative Biology. 66: 293-300. PMID 12762031  1
2001 Svitkin YV, Imataka H, Khaleghpour K, Kahvejian A, Liebig HD, Sonenberg N. Poly(A)-binding protein interaction with elF4G stimulates picornavirus IRES-dependent translation. Rna (New York, N.Y.). 7: 1743-52. PMID 11780631  1
2001 Schneider R, Agol VI, Andino R, Bayard F, Cavener DR, Chappell SA, Chen JJ, Darlix JL, Dasgupta A, Donzé O, Duncan R, Elroy-Stein O, Farabaugh PJ, Filipowicz W, Gale M, ... ... Sonenberg N, et al. New ways of initiating translation in eukaryotes. Molecular and Cellular Biology. 21: 8238-46. PMID 11710333 DOI: 10.1128/MCB.21.23.8238-8246.2001  1
2001 Hentges KE, Sirry B, Gingeras AC, Sarbassov D, Sonenberg N, Sabatini D, Peterson AS. FRAP/mTOR is required for proliferation and patterning during embryonic development in the mouse. Proceedings of the National Academy of Sciences of the United States of America. 98: 13796-801. PMID 11707573 DOI: 10.1073/pnas.241184198  1
2001 Miron M, Sonenberg N. Regulation of translation via TOR signaling: insights from Drosophila melanogaster. The Journal of Nutrition. 131: 2988S-93S. PMID 11694634  0.36
2001 Gingras AC, Raught B, Gygi SP, Niedzwiecka A, Miron M, Burley SK, Polakiewicz RD, Wyslouch-Cieszynska A, Aebersold R, Sonenberg N. Hierarchical phosphorylation of the translation inhibitor 4E-BP1. Genes & Development. 15: 2852-64. PMID 11691836 DOI: 10.1101/gad.912401  1
2001 Tsukiyama-Kohara K, Poulin F, Kohara M, DeMaria CT, Cheng A, Wu Z, Gingras AC, Katsume A, Elchebly M, Spiegelman BM, Harper ME, Tremblay ML, Sonenberg N. Adipose tissue reduction in mice lacking the translational inhibitor 4E-BP1. Nature Medicine. 7: 1128-32. PMID 11590436 DOI: 10.1038/nm1001-1128  1
2001 Gingras AC, Raught B, Sonenberg N. Control of translation by the target of rapamycin proteins. Progress in Molecular and Subcellular Biology. 27: 143-74. PMID 11575159  1
2001 Evdokimova V, Ruzanov P, Imataka H, Raught B, Svitkin Y, Ovchinnikov LP, Sonenberg N. The major mRNA-associated protein YB-1 is a potent 5' cap-dependent mRNA stabilizer. The Embo Journal. 20: 5491-502. PMID 11574481 DOI: 10.1093/emboj/20.19.5491  1
2001 Mazumder B, Seshadri V, Imataka H, Sonenberg N, Fox PL. Translational silencing of ceruloplasmin requires the essential elements of mRNA circularization: poly(A) tail, poly(A)-binding protein, and eukaryotic translation initiation factor 4G. Molecular and Cellular Biology. 21: 6440-9. PMID 11533233 DOI: 10.1128/MCB.21.19.6440-6449.2001  1
2001 Pyronnet S, Dostie J, Sonenberg N. Suppression of cap-dependent translation in mitosis. Genes & Development. 15: 2083-93. PMID 11511540 DOI: 10.1101/gad.889201  1
2001 Khaleghpour K, Kahvejian A, De Crescenzo G, Roy G, Svitkin YV, Imataka H, O'Connor-McCourt M, Sonenberg N. Dual interactions of the translational repressor Paip2 with poly(A) binding protein. Molecular and Cellular Biology. 21: 5200-13. PMID 11438674 DOI: 10.1128/MCB.21.15.5200-5213.2001  1
2001 Raught B, Gingras AC, Sonenberg N. The target of rapamycin (TOR) proteins. Proceedings of the National Academy of Sciences of the United States of America. 98: 7037-44. PMID 11416184 DOI: 10.1073/pnas.121145898  1
2001 Cormier P, Pyronnet S, Morales J, Mulner-Lorillon O, Sonenberg N, Bellé R. eIF4E association with 4E-BP decreases rapidly following fertilization in sea urchin. Developmental Biology. 232: 275-83. PMID 11401391 DOI: 10.1006/dbio.2001.0206  0.64
2001 Miron M, Verdú J, Lachance PE, Birnbaum MJ, Lasko PF, Sonenberg N. The translational inhibitor 4E-BP is an effector of PI(3)K/Akt signalling and cell growth in Drosophila. Nature Cell Biology. 3: 596-601. PMID 11389445 DOI: 10.1038/35078571  1
2001 Svitkin YV, Pause A, Haghighat A, Pyronnet S, Witherell G, Belsham GJ, Sonenberg N. The requirement for eukaryotic initiation factor 4A (elF4A) in translation is in direct proportion to the degree of mRNA 5' secondary structure. Rna (New York, N.Y.). 7: 382-94. PMID 11333019 DOI: 10.1017/S135583820100108X  1
2001 Gingras AC, Raught B, Sonenberg N. Regulation of translation initiation by FRAP/mTOR. Genes & Development. 15: 807-26. PMID 11297505 DOI: 10.1101/gad.887201  1
2001 Deo RC, Sonenberg N, Burley SK. X-ray structure of the human hyperplastic discs protein: an ortholog of the C-terminal domain of poly(A)-binding protein. Proceedings of the National Academy of Sciences of the United States of America. 98: 4414-9. PMID 11287654 DOI: 10.1073/pnas.071552198  1
2001 Bhandari BK, Feliers D, Duraisamy S, Stewart JL, Gingras AC, Abboud HE, Choudhury GG, Sonenberg N, Kasinath BS. Insulin regulation of protein translation repressor 4E-BP1, an eIF4E-binding protein, in renal epithelial cells. Kidney International. 59: 866-75. PMID 11231341 DOI: 10.1046/j.1523-1755.2001.059003866.x  1
2001 Khaleghpour K, Svitkin YV, Craig AW, DeMaria CT, Deo RC, Burley SK, Sonenberg N. Translational repression by a novel partner of human poly(A) binding protein, Paip2. Molecular Cell. 7: 205-16. PMID 11172725 DOI: 10.1016/S1097-2765(01)00168-X  1
2001 Marcotrigiano J, Lomakin IB, Sonenberg N, Pestova TV, Hellen CU, Burley SK. A conserved HEAT domain within eIF4G directs assembly of the translation initiation machinery. Molecular Cell. 7: 193-203. PMID 11172724  0.48
2001 Pyronnet S, Sonenberg N. Cell-cycle-dependent translational control. Current Opinion in Genetics & Development. 11: 13-8. PMID 11163145  0.64
2000 Marissen WE, Gradi A, Sonenberg N, Lloyd RE. Cleavage of eukaryotic translation initiation factor 4GII correlates with translation inhibition during apoptosis. Cell Death and Differentiation. 7: 1234-43. PMID 11175261 DOI: 10.1038/sj.cdd.4400750  1
2000 Grosset C, Chen CY, Xu N, Sonenberg N, Jacquemin-Sablon H, Shyu AB. A mechanism for translationally coupled mRNA turnover: interaction between the poly(A) tail and a c-fos RNA coding determinant via a protein complex. Cell. 103: 29-40. PMID 11051545  0.52
2000 Holcik M, Sonenberg N, Korneluk RG. Internal ribosome initiation of translation and the control of cell death. Trends in Genetics : Tig. 16: 469-73. PMID 11050335 DOI: 10.1016/S0168-9525(00)02106-5  1
2000 Dostie J, Ferraiuolo M, Pause A, Adam SA, Sonenberg N. A novel shuttling protein, 4E-T, mediates the nuclear import of the mRNA 5' cap-binding protein, eIF4E. The Embo Journal. 19: 3142-56. PMID 10856257 DOI: 10.1093/emboj/19.12.3142  1
2000 Cosentino GP, Schmelzle T, Haghighat A, Helliwell SB, Hall MN, Sonenberg N. Eap1p, a novel eukaryotic translation initiation factor 4E-associated protein in Saccharomyces cerevisiae. Molecular and Cellular Biology. 20: 4604-13. PMID 10848587 DOI: 10.1128/MCB.20.13.4604-4613.2000  1
2000 Polunovsky VA, Gingras AC, Sonenberg N, Peterson M, Tan A, Rubins JB, Manivel JC, Bitterman PB. Translational control of the antiapoptotic function of Ras. The Journal of Biological Chemistry. 275: 24776-80. PMID 10811643 DOI: 10.1074/jbc.M001938200  1
2000 Kumar V, Sabatini D, Pandey P, Gingras AC, Majumder PK, Kumar M, Yuan ZM, Carmichael G, Weichselbaum R, Sonenberg N, Kufe D, Kharbanda S. Regulation of the rapamycin and FKBP-target 1/mammalian target of rapamycin and cap-dependent initiation of translation by the c-Abl protein-tyrosine kinase. The Journal of Biological Chemistry. 275: 10779-87. PMID 10753870 DOI: 10.1074/jbc.275.15.10779  1
2000 Raught B, Gingras AC, Gygi SP, Imataka H, Morino S, Gradi A, Aebersold R, Sonenberg N. Serum-stimulated, rapamycin-sensitive phosphorylation sites in the eukaryotic translation initiation factor 4GI. The Embo Journal. 19: 434-44. PMID 10654941 DOI: 10.1093/emboj/19.3.434  1
2000 Goldstaub D, Gradi A, Bercovitch Z, Grosmann Z, Nophar Y, Luria S, Sonenberg N, Kahana C. Poliovirus 2A protease induces apoptotic cell death. Molecular and Cellular Biology. 20: 1271-7. PMID 10648613 DOI: 10.1128/MCB.20.4.1271-1277.2000  1
2000 Dostie J, Lejbkowicz F, Sonenberg N. Nuclear eukaryotic initiation factor 4E (eIF4E) colocalizes with splicing factors in speckles. The Journal of Cell Biology. 148: 239-47. PMID 10648556 DOI: 10.1083/jcb.148.2.239  1
1999 Gingras AC, Raught B, Sonenberg N. eIF4 initiation factors: effectors of mRNA recruitment to ribosomes and regulators of translation. Annual Review of Biochemistry. 68: 913-63. PMID 10872469 DOI: 10.1146/annurev.biochem.68.1.913  1
1999 Takata M, Ogawa W, Kitamura T, Hino Y, Kuroda S, Kotani K, Klip A, Gingras AC, Sonenberg N, Kasuga M. Requirement for Akt (protein kinase B) in insulin-induced activation of glycogen synthase and phosphorylation of 4E-BP1 (PHAS-1). The Journal of Biological Chemistry. 274: 20611-8. PMID 10400692 DOI: 10.1074/jbc.274.29.20611  1
1999 Marcotrigiano J, Gingras AC, Sonenberg N, Burley SK. Cap-dependent translation initiation in eukaryotes is regulated by a molecular mimic of eIF4G. Molecular Cell. 3: 707-16. PMID 10394359 DOI: 10.1016/S1097-2765(01)80003-4  1
1999 Gingras AC, Gygi SP, Raught B, Polakiewicz RD, Abraham RT, Hoekstra MF, Aebersold R, Sonenberg N. Regulation of 4E-BP1 phosphorylation: a novel two-step mechanism. Genes & Development. 13: 1422-37. PMID 10364159  1
1999 Khaleghpour K, Pyronnet S, Gingras AC, Sonenberg N. Translational homeostasis: eukaryotic translation initiation factor 4E control of 4E-binding protein 1 and p70 S6 kinase activities. Molecular and Cellular Biology. 19: 4302-10. PMID 10330171  1
1999 Rao GN, Madamanchi NR, Lele M, Gadiparthi L, Gingras AC, Eling TE, Sonenberg N. A potential role for extracellular signal-regulated kinases in prostaglandin F2alpha-induced protein synthesis in smooth muscle cells. The Journal of Biological Chemistry. 274: 12925-32. PMID 10212283 DOI: 10.1074/jbc.274.18.12925  1
1999 Gygi SP, Han DK, Gingras AC, Sonenberg N, Aebersold R. Protein analysis by mass spectrometry and sequence database searching: tools for cancer research in the post-genomic era. Electrophoresis. 20: 310-9. PMID 10197438 DOI: 10.1002/(SICI)1522-2683(19990201)20:2<310::AID-ELPS310>3.0.CO;2-M  1
1999 Donzé O, Dostie J, Sonenberg N. Regulatable expression of the interferon-induced double-stranded RNA dependent protein kinase PKR induces apoptosis and fas receptor expression. Virology. 256: 322-9. PMID 10191197 DOI: 10.1006/viro.1999.9618  1
1999 Svitkin YV, Gradi A, Imataka H, Morino S, Sonenberg N. Eukaryotic initiation factor 4GII (eIF4GII), but not eIF4GI, cleavage correlates with inhibition of host cell protein synthesis after human rhinovirus infection. Journal of Virology. 73: 3467-72. PMID 10074204  1
1999 Pyronnet S, Imataka H, Gingras AC, Fukunaga R, Hunter T, Sonenberg N. Human eukaryotic translation initiation factor 4G (eIF4G) recruits mnk1 to phosphorylate eIF4E. The Embo Journal. 18: 270-9. PMID 9878069 DOI: 10.1093/emboj/18.1.270  1
1998 Imataka H, Gradi A, Sonenberg N. A newly identified N-terminal amino acid sequence of human eIF4G binds poly(A)-binding protein and functions in poly(A)-dependent translation. The Embo Journal. 17: 7480-9. PMID 9857202 DOI: 10.1093/emboj/17.24.7480  1
1998 Gradi A, Svitkin YV, Imataka H, Sonenberg N. Proteolysis of human eukaryotic translation initiation factor eIF4GII, but not eIF4GI, coincides with the shutoff of host protein synthesis after poliovirus infection. Proceedings of the National Academy of Sciences of the United States of America. 95: 11089-94. PMID 9736694 DOI: 10.1073/pnas.95.19.11089  1
1998 Polakiewicz RD, Schieferl SM, Gingras AC, Sonenberg N, Comb MJ. mu-Opioid receptor activates signaling pathways implicated in cell survival and translational control. The Journal of Biological Chemistry. 273: 23534-41. PMID 9722592 DOI: 10.1074/jbc.273.36.23534  1
1998 Svitkin YV, Hahn H, Gingras AC, Palmenberg AC, Sonenberg N. Rapamycin and wortmannin enhance replication of a defective encephalomyocarditis virus. Journal of Virology. 72: 5811-9. PMID 9621041  0.6
1998 Pyronnet S, Gingras AC, Bouisson M, Kowalski-Chauvel A, Seva C, Vaysse N, Sonenberg N, Pradayrol L. Gastrin induces phosphorylation of eIF4E binding protein 1 and translation initiation of ornithine decarboxylase mRNA. Oncogene. 16: 2219-27. PMID 9619831 DOI: 10.1038/sj.onc.1201748  0.64
1998 Poulin F, Gingras AC, Olsen H, Chevalier S, Sonenberg N. 4E-BP3, a new member of the eukaryotic initiation factor 4E-binding protein family. The Journal of Biological Chemistry. 273: 14002-7. PMID 9593750 DOI: 10.1074/jbc.273.22.14002  1
1998 Gradi A, Imataka H, Svitkin YV, Rom E, Raught B, Morino S, Sonenberg N. A novel functional human eukaryotic translation initiation factor 4G. Molecular and Cellular Biology. 18: 334-42. PMID 9418880  1
1996 Craig AW, Cosentino GP, Donzé O, Sonenberg N. The kinase insert domain of interferon-induced protein kinase PKR is required for activity but not for interaction with the pseudosubstrate K3L. The Journal of Biological Chemistry. 271: 24526-33. PMID 8798713 DOI: 10.1074/jbc.271.40.24526  1
1995 Silveira Carneiro J, Equestre M, Pagnotti P, Gradi A, Sonenberg N, Perez Bercoff R. 5' UTR of hepatitis A virus RNA: mutations in the 5'-most pyrimidine-rich tract reduce its ability to direct internal initiation of translation. The Journal of General Virology. 76: 1189-96. PMID 7730803 DOI: 10.1099/0022-1317-76-5-1189  1
1995 Cosentino GP, Venkatesan S, Serluca FC, Green SR, Mathews MB, Sonenberg N. Double-stranded-RNA-dependent protein kinase and TAR RNA-binding protein form homo- and heterodimers in vivo. Proceedings of the National Academy of Sciences of the United States of America. 92: 9445-9. PMID 7568151 DOI: 10.1073/pnas.92.21.9445  1
1981 Rupprecht KM, Sonenberg N, Shatkin AJ, Hecht SM. Design and preparation of affinity columns for the purification of eukaryotic messenger ribonucleic acid cap binding protein. Biochemistry. 20: 6570-7. PMID 7306524  1
1980 Bonatti S, Sonenberg N, Shatkin AJ, Cancedda R. Restricted initiation of protein synthesis on the potentially polycistronic Sindbis virus 42 S RNA. The Journal of Biological Chemistry. 255: 11473-7. PMID 7440550  1
1980 Sonenberg N, Trachsel H, Hecht S, Shatkin AJ. Differential stimulation of capped mRNA translation in vitro by cap binding protein. Nature. 285: 331-3. PMID 6246452 DOI: 10.1038/285331a0  1
1980 Trachsel H, Sonenberg N, Shatkin AJ, Rose JK, Leong K, Bergmann JE, Gordon J, Baltimore D. Purification of a factor that restores translation of vesicular stomatitis virus mRNA in extracts from poliovirus-infected HeLa cells. Proceedings of the National Academy of Sciences of the United States of America. 77: 770-4. PMID 6244584  1
1979 Bergmann JE, Trachsel H, Sonenberg N, Shatkin AJ, Lodish HF. Characterization of rabbit reticulocyte factor(s) that stimulates the translation of mRNAs lacking 5'-terminal 7-methylguanosine. The Journal of Biological Chemistry. 254: 1440-3. PMID 762141  1
1979 Sonenberg N, Morgan MA, Testa D, Colonno RJ, Shatkin AJ. Interaction of a limited set of proteins with different mRNAs and protection of 5'-caps against pyrophosphatase digestion in initiation complexes. Nucleic Acids Research. 7: 15-29. PMID 493138 DOI: 10.1093/nar/7.1.15  1
1979 Sonenberg N, Rupprecht KM, Hecht SM, Shatkin AJ. Eukaryotic mRNA cap binding protein: purification by affinity chromatography on sepharose-coupled m7GDP. Proceedings of the National Academy of Sciences of the United States of America. 76: 4345-9. PMID 291969  1
1978 Sonenberg N, Shatkin AJ, Ricciardi RP, Rubin M, Goodman RM. Analysis of terminal structures of RNA from potato virus X. Nucleic Acids Research. 5: 2501-12. PMID 673859  1
1978 Sonenberg N, Morgan MA, Merrick WC, Shatkin AJ. A polypeptide in eukaryotic initiation factors that crosslinks specifically to the 5'-terminal cap in mRNA. Proceedings of the National Academy of Sciences of the United States of America. 75: 4843-7. PMID 217002  1
1978 Sonenberg N, Shatkin AJ. Nonspecific effect of m7GMP on protein-RNA interactions. The Journal of Biological Chemistry. 253: 6630-2. PMID 211125  1
1977 Sonenberg N, Shatkin AJ. Reovirus mRNA can be covalently crosslinked via the 5' cap to proteins in initiation complexes. Proceedings of the National Academy of Sciences of the United States of America. 74: 4288-92. PMID 270673  1
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