Juan Saavedra - Publications

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63 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2017 Zhou J, Burns MP, Huynh L, Villapol S, Taub DD, Saavedra JM, Blackman MR. Temporal Changes in Cortical and Hippocampal Expression of Genes Important for Brain Glucose Metabolism Following Controlled Cortical Impact Injury in Mice. Frontiers in Endocrinology. 8: 231. PMID 28955302 DOI: 10.3389/fendo.2017.00231  1
2016 Elkahloun AG, Hafko R, Saavedra JM. An integrative genome-wide transcriptome reveals that candesartan is neuroprotective and a candidate therapeutic for Alzheimer's disease. Alzheimer's Research & Therapy. 8: 5. PMID 26822027 DOI: 10.1186/s13195-015-0167-5  0.4
2015 Gao Y, Xu X, Chang S, Wang Y, Xu Y, Ran S, Huang Z, Li P, Li J, Zhang L, Saavedra JM, Liao H, Pang T. Totarol prevents neuronal injury in vitro and ameliorates brain ischemic stroke: Potential roles of Akt activation and HO-1 induction. Toxicology and Applied Pharmacology. PMID 26440581 DOI: 10.1016/j.taap.2015.10.001  0.88
2015 Villapol S, Kryndushkin D, Balarezo MG, Campbell AM, Saavedra JM, Shewmaker FP, Symes AJ. Hepatic Expression of Serum Amyloid A1 Is Induced by Traumatic Brain Injury and Modulated by Telmisartan. The American Journal of Pathology. 185: 2641-52. PMID 26435412 DOI: 10.1016/j.ajpath.2015.06.016  0.88
2015 Xu Y, Xu Y, Wang Y, Wang Y, He L, Jiang Z, Huang Z, Liao H, Li J, Saavedra JM, Zhang L, Pang T. Telmisartan prevention of LPS-induced microglia activation involves M2 microglia polarization via CaMKKβ-dependent AMPK activation. Brain, Behavior, and Immunity. PMID 26188187 DOI: 10.1016/j.bbi.2015.07.015  1
2015 Villapol S, Balarezo MG, Affram K, Saavedra JM, Symes AJ. Neurorestoration after traumatic brain injury through angiotensin II receptor blockage. Brain : a Journal of Neurology. 138: 3299-315. PMID 26115674 DOI: 10.1093/brain/awv172  0.88
2015 Villapol S, Saavedra JM. Neuroprotective effects of angiotensin receptor blockers. American Journal of Hypertension. 28: 289-99. PMID 25362113 DOI: 10.1093/ajh/hpu197  1
2014 Wang J, Pang T, Hafko R, Benicky J, Sanchez-Lemus E, Saavedra JM. Telmisartan ameliorates glutamate-induced neurotoxicity: roles of AT(1) receptor blockade and PPARγ activation. Neuropharmacology. 79: 249-61. PMID 24316465 DOI: 10.1016/j.neuropharm.2013.11.022  1
2013 Sohn YI, Lee NJ, Chung A, Saavedra JM, Scott Turner R, Pak DT, Hoe HS. Antihypertensive drug Valsartan promotes dendritic spine density by altering AMPA receptor trafficking. Biochemical and Biophysical Research Communications. 439: 464-70. PMID 24012668 DOI: 10.1016/j.bbrc.2013.08.091  1
2013 Hafko R, Villapol S, Nostramo R, Symes A, Sabban EL, Inagami T, Saavedra JM. Commercially available angiotensin II Atâ‚‚ receptor antibodies are nonspecific. Plos One. 8: e69234. PMID 23840911 DOI: 10.1371/journal.pone.0069234  1
2012 Nostramo R, Tillinger A, Saavedra JM, Kumar A, Pandey V, Serova L, Kvetnansky R, Sabban EL. Regulation of angiotensin II type 2 receptor gene expression in the adrenal medulla by acute and repeated immobilization stress. The Journal of Endocrinology. 215: 291-301. PMID 22911895 DOI: 10.1530/JOE-12-0181  1
2012 Villapol S, Yaszemski AK, Logan TT, Sánchez-Lemus E, Saavedra JM, Symes AJ. Candesartan, an angiotensin II AT₁-receptor blocker and PPAR-γ agonist, reduces lesion volume and improves motor and memory function after traumatic brain injury in mice. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 37: 2817-29. PMID 22892395 DOI: 10.1038/npp.2012.152  1
2012 Benicky J, Hafko R, Sanchez-Lemus E, Aguilera G, Saavedra JM. Six commercially available angiotensin II AT1 receptor antibodies are non-specific. Cellular and Molecular Neurobiology. 32: 1353-65. PMID 22843099 DOI: 10.1007/s10571-012-9862-y  1
2012 Pang T, Wang J, Benicky J, Sánchez-Lemus E, Saavedra JM. Telmisartan directly ameliorates the neuronal inflammatory response to IL-1β partly through the JNK/c-Jun and NADPH oxidase pathways. Journal of Neuroinflammation. 9: 102. PMID 22642771 DOI: 10.1186/1742-2094-9-102  0.92
2012 Sánchez-Lemus E, Honda M, Saavedra JM. Angiotensin II AT1 receptor blocker candesartan prevents the fast up-regulation of cerebrocortical benzodiazepine-1 receptors induced by acute inflammatory and restraint stress. Behavioural Brain Research. 232: 84-92. PMID 22503782 DOI: 10.1016/j.bbr.2012.03.041  0.92
2011 Benicky J, Sánchez-Lemus E, Honda M, Pang T, Orecna M, Wang J, Leng Y, Chuang DM, Saavedra JM. Angiotensin II AT1 receptor blockade ameliorates brain inflammation. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 36: 857-70. PMID 21150913 DOI: 10.1038/npp.2010.225  1
2011 Saavedra JM, Sánchez-Lemus E, Benicky J. Blockade of brain angiotensin II AT1 receptors ameliorates stress, anxiety, brain inflammation and ischemia: Therapeutic implications. Psychoneuroendocrinology. 36: 1-18. PMID 21035950 DOI: 10.1016/j.psyneuen.2010.10.001  0.92
2009 Pavel J, Terrón JA, Benicky J, Falcón-Neri A, Rachakonda A, Inagami T, Saavedra JM. Increased angiotensin II AT1 receptor mRNA and binding in spleen and lung of AT2 receptor gene disrupted mice. Regulatory Peptides. 158: 156-66. PMID 19766151 DOI: 10.1016/j.regpep.2009.09.004  0.4
2009 Larrayoz IM, Pang T, Benicky J, Pavel J, Sánchez-Lemus E, Saavedra JM. Candesartan reduces the innate immune response to lipopolysaccharide in human monocytes. Journal of Hypertension. 27: 2365-76. PMID 19730394 DOI: 10.1097/HJH.0b013e3283314bc7  0.92
2009 Sánchez-Lemus E, Benicky J, Pavel J, Saavedra JM. In vivo Angiotensin II AT1 receptor blockade selectively inhibits LPS-induced innate immune response and ACTH release in rat pituitary gland. Brain, Behavior, and Immunity. 23: 945-57. PMID 19427376 DOI: 10.1016/j.bbi.2009.04.012  0.92
2009 Imboden H, Patil J, Nussberger J, Nicoud F, Hess B, Ahmed N, Schaffner T, Wellner M, Müller D, Inagami T, Senbonmatsu T, Pavel J, Saavedra JM. Endogenous angiotensinergic system in neurons of rat and human trigeminal ganglia. Regulatory Peptides. 154: 23-31. PMID 19323983 DOI: 10.1016/j.regpep.2009.02.002  0.4
2009 Benicky J, Sánchez-Lemus E, Pavel J, Saavedra JM. Anti-inflammatory effects of angiotensin receptor blockers in the brain and the periphery. Cellular and Molecular Neurobiology. 29: 781-92. PMID 19259805 DOI: 10.1007/s10571-009-9368-4  0.92
2009 Sánchez-Lemus E, Benicky J, Pavel J, Larrayoz IM, Zhou J, Baliova M, Nishioku T, Saavedra JM. Angiotensin II AT1 blockade reduces the lipopolysaccharide-induced innate immune response in rat spleen. American Journal of Physiology. Regulatory, Integrative and Comparative Physiology. 296: R1376-84. PMID 19225144 DOI: 10.1152/ajpregu.90962.2008  0.92
2004 Tjurmina OA, Armando I, Saavedra JM, Li Q, Murphy DL. Life-long serotonin reuptake deficiency results in complex alterations in adrenomedullary responses to stress. Annals of the New York Academy of Sciences. 1018: 99-104. PMID 15240357 DOI: 10.1196/annals.1296.011  0.56
2003 Yamakawa H, Phillips MI, Saavedra JM. Intracisternal administration of Angiotensin II AT1 receptor antisense oligodeoxynucleotides protects against cerebral ischemia in spontaneously hypertensive rats. Regulatory Peptides. 111: 117-22. PMID 12609758 DOI: 10.1016/S0167-0115(02)00264-1  1
2002 Tjurmina OA, Armando I, Saavedra JM, Goldstein DS, Murphy DL. Exaggerated adrenomedullary response to immobilization in mice with targeted disruption of the serotonin transporter gene. Endocrinology. 143: 4520-6. PMID 12446578 DOI: 10.1210/en.2002-220416  0.56
2002 Armando I, Terrón JA, Falcón-Neri A, Takeshi I, Häuser W, Inagami T, Saavedra JM. Increased angiotensin II AT(1) receptor expression in paraventricular nucleus and hypothalamic-pituitary-adrenal axis stimulation in AT(2) receptor gene disrupted mice. Neuroendocrinology. 76: 137-47. PMID 12218346  0.4
1991 Ray PE, Castrén E, Ruley EJ, Saavedra JM. Different effects of chronic Na+, Cl-, and K+ depletion on brain vasopressin mRNA and plasma vasopressin in young rats. Cellular and Molecular Neurobiology. 11: 277-87. PMID 2029728 DOI: 10.1007/BF00769040  0.56
1990 Ray PE, Castrén E, Ruley EJ, Saavedra JM. Different effects of sodium or chloride depletion on angiotensin II receptors in rats. The American Journal of Physiology. 258: R1008-15. PMID 2331021  0.56
1989 Laitinen JT, Castren E, Vakkuri O, Saavedra JM. Diurnal rhythm of melatonin binding in the rat suprachiasmatic nucleus. Endocrinology. 124: 1585-7. PMID 2917527 DOI: 10.1210/endo-124-3-1585  0.56
1989 Castrén E, Saavedra JM. Lack of vasopressin increases hypothalamic atrial natriuretic peptide binding sites. The American Journal of Physiology. 257: R168-73. PMID 2546454  0.56
1988 Gutkind JS, Kurihara M, Castren E, Saavedra JM. Increased concentration of angiotensin II binding sites in selected brain areas of spontaneously hypertensive rats. Journal of Hypertension. 6: 79-84. PMID 3351297  0.56
1988 Castren E, Saavedra JM. Repeated stress increases the density of angiotensin II binding sites in rat paraventricular nucleus and subfornical organ. Endocrinology. 122: 370-2. PMID 3335214 DOI: 10.1210/endo-122-1-370  0.56
1987 Shigematsu K, Niwa M, Kurihara M, Castren E, Saavedra JM. Alterations in substance P binding in brain nuclei of spontaneously hypertensive rats. The American Journal of Physiology. 252: H301-6. PMID 2433950  0.56
1979 Paul SM, Axelrod J, Saavedra JM, Skolnick P. Estrogen-induced efflux of endogenous catecholamines from the hypothalamus in vitro. Brain Research. 178: 499-505. PMID 228795 DOI: 10.1016/0006-8993(79)90709-1  0.56
1978 Saavedra JM, Grobecker H, Axelrod J. Changes in central catecholaminergic neurons in the spontaneously (genetic) hypertensive rat. Circulation Research. 42: 529-34. PMID 630670  0.64
1977 Kebabian JW, Saavedra JM, Axelrod J. A sensitive enzymatic-radioisotopic assay for 3,4-dihydroxyphenylacetic acid. Journal of Neurochemistry. 28: 795-801. PMID 894287  0.64
1977 Saavedra JM, Grobecker H, Axelrod J. Biochemical and morphologic study of catecholamine metabolism in spontaneously hypertensive rats. Mayo Clinic Proceedings. 52: 391-4. PMID 865135  0.64
1977 Axelrod J, Saavedra JM. Octopamine. Nature. 265: 501-4. PMID 13310 DOI: 10.1038/265501a0  0.56
1976 Saavedra JM, Grobecker H, Axelrod J. Adrenaline-forming enzyme in brainstem: elevation in genetic and experimental hypertension. Science (New York, N.Y.). 191: 483-4. PMID 1246633  0.64
1976 Tallman JF, Saavedra JM, Axelrod J. A sensitive enzymatic-isotopic method for the analysis of tyramine in brain and other tissues. Journal of Neurochemistry. 27: 465-9. PMID 965987  0.56
1976 Saavedra JM, Axelrod J. Octopamine as a putative neurotransmitter. Advances in Biochemical Psychopharmacology. 15: 95-110. PMID 799466  0.56
1976 Grobecker H, Saavedra JM, Roizen MF, Weise V, Kopin IJ, Axelrod J. Peripheral and central catecholaminergic neurons in genetic and experimental hypertension in rats. Clinical Science and Molecular Medicine. Supplement. 3: 377s-380s. PMID 15756  0.64
1976 Tallman JF, Saavedra JM, Axelrod J. Biosynthesis and metabolism of endogenous tyramine and its normal presence in sympathetic nerves. The Journal of Pharmacology and Experimental Therapeutics. 199: 216-21. PMID 10424  0.56
1975 Wooten GF, Jacobowitz DM, Saavedra JM, Axelrod J. Localization of extraneuronal dopamine-beta-hydroxylase in rat salivary gland by immunofluorescence histochemistry. Journal of Neurochemistry. 24: 1107-10. PMID 1092811  0.56
1974 Saavedra JM, Palkovits M, Brownstein MJ, Axelrod J. Serotonin distribution in the nuclei of the rat hypothalamus and preoptic region. Brain Research. 77: 157-65. PMID 4854251  0.64
1974 Palkovits M, Brownstein M, Saavedra JM, Axelrod J. Norepinephrine and dopamine content of hypothalamic nuclei of the rat. Brain Research. 77: 137-49. PMID 4853370  0.64
1974 Saavedra JM, Palkovits M, Brownstein MJ, Axelrod J. Localisation of phenylethanolamine N-methyl transferase in the rat brain nuclei. Nature. 248: 695-6. PMID 4833273  0.64
1974 Saavedra JM, Axelrod J. Enzymatic-isotopic micromethods for the measurement of biogenic amines in brain tissue and body fluids Journal of Psychiatric Research. 11: 289-291. PMID 4618286 DOI: 10.1016/0022-3956(74)90108-3  0.56
1974 Brownstein MJ, Saavedra JM, Axelrod J, Zeman GH, Carpenter DO. Coexistence of several putative neurotransmitters in single identified neurons of Aplysia. Proceedings of the National Academy of Sciences of the United States of America. 71: 4662-5. PMID 4373726  0.64
1974 Saavedra JM, Axelrod J. Brain tryptamine and the effects of drugs Advances in Biochemical Psychopharmacology. 10: 135-139. PMID 4276952  0.56
1974 Brownstein MJ, Saavedra JM, Palkovits M, Axelrod J. Histamine content of hypothalamic nuclei of the rat. Brain Research. 77: 151-6. PMID 4212053  0.64
1974 Saavedra JM, Brownstein M, Palkovits M, Kizer S, Axelrod J. Tyrosine hydroxylase and dopamine-beta-hydroxylase: distribution in the individual rat hypothalamic nuclei. Journal of Neurochemistry. 23: 869-71. PMID 4154360  0.64
1974 Saavedra JM, Coyle JT, Axelrod J. Developmental characteristics of phenylethanolamine and octopamine in the rat brain. Journal of Neurochemistry. 23: 511-5. PMID 4153859  0.64
1974 Saavedra JM, Brownstein MJ, Carpenter DO, Axelrod J. Octopamine: presence in single neurons of Aplysia suggests neurotransmitter function. Science (New York, N.Y.). 185: 364-5. PMID 4151812  0.64
1973 Saavedra JM, Brownstein M, Axelrod J. A specific and sensitive enzymatic-isotopic microassay for serotonin in tissues. The Journal of Pharmacology and Experimental Therapeutics. 186: 508-15. PMID 4728332  0.64
1973 Saavedra JM, Coyle JT, Axelrod J. The distribution and properties of the nonspecific N-methyltransferase in brain. Journal of Neurochemistry. 20: 743-52. PMID 4703789  0.64
1973 Wyatt RJ, Saavedra JM, Axelrod J. A dimethyltryptamine-forming enzyme in human blood. The American Journal of Psychiatry. 130: 754-60. PMID 4514540  0.64
1973 Saavedra JM, Axelrod J. Demonstration and distribution of phenylethanolamine in brain and other tissues Proceedings of the National Academy of Sciences of the United States of America. 70: 769-772. PMID 4268476  0.56
1973 Saavedra JM, Axelrod J. Effect of drugs on the tryptamine content of rat tissues Journal of Pharmacology and Experimental Therapeutics. 185: 523-529. PMID 4268231  0.56
1973 Brownstein M, Saavedra JM, Axelrod J. Control of pineal N-acetylserotonin by a beta adrenergic receptor. Molecular Pharmacology. 9: 605-11. PMID 4150902  0.64
1972 Saavedra JM, Axelrod J. Psychotomimetic N-methylated tryptamines: Formation in brain in vivo and in vitro Science. 175: 1365-1366. PMID 5059565  0.56
1972 Saavedra JM, Axelrod J. A specific and sensitive enzymatic assay for tryptamine in tissues Journal of Pharmacology and Experimental Therapeutics. 182: 363-369. PMID 5055399  0.56
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