| Year |
Citation |
Score |
| 2024 |
Amuti S, Saito Y, Fukuyoshi S, Miyake K, Newman DJ, O'Keefe BR, Lee KH, Nakagawa-Goto K. Unusual Vilasinin-Class Limonoids from . Molecules (Basel, Switzerland). 29. PMID 38338394 DOI: 10.3390/molecules29030651 |
0.322 |
|
| 2024 |
Kobayashi A, Saito Y, Miyake K, Fukuyoshi S, Newman DJ, O'Keefe BR, Lee KH, Nakagawa-Goto K. Caged Xanthones and Biphenyls Isolated from the Tropical Plant . Journal of Natural Products. PMID 38251859 DOI: 10.1021/acs.jnatprod.3c00934 |
0.309 |
|
| 2023 |
Wang M, Rousseau B, Qiu K, Huang G, Zhang Y, Su H, Le Bihan-Benjamin C, Khati I, Artz O, Foote MB, Cheng YY, Lee KH, Miao MZ, Sun Y, Bousquet PJ, et al. Killing tumor-associated bacteria with a liposomal antibiotic generates neoantigens that induce anti-tumor immune responses. Nature Biotechnology. PMID 37749267 DOI: 10.1038/s41587-023-01957-8 |
0.617 |
|
| 2022 |
Tanaka N, Takahashi S, Yoshino Y, Nakatani M, Ahmed FA, Hossain GM, Chen CH, Lee KH, Kashiwada Y. Tigliane-Type Diterpene Esters from the Fruits of and Their Anti-HIV Activity. Journal of Natural Products. 85: 2687-2693. PMID 36378070 DOI: 10.1021/acs.jnatprod.2c00752 |
0.329 |
|
| 2022 |
Wada K, Goto M, Tanaka H, Mizukami M, Suzuki Y, Lee KH, Yamashita H. Discovery of C-Diterpenoid Alkaloid Kobusine Derivatives Exhibiting Sub-G1 Inducing Activity. Acs Omega. 7: 28173-28181. PMID 35990488 DOI: 10.1021/acsomega.2c02363 |
0.346 |
|
| 2022 |
Xi W, Sun H, Bastow KF, Xiao Z, Lee KH. Identification of Novel 4'--Demethyl-epipodophyllotoxin Derivatives as Antitumor Agents Targeting Topoisomerase II. Molecules (Basel, Switzerland). 27. PMID 35956979 DOI: 10.3390/molecules27155029 |
0.589 |
|
| 2021 |
Xie L, Goto M, Chen X, Morris-Natschke SL, Lee KH. Lead Optimization: Synthesis and Biological Evaluation of PBT-1 Derivatives as Novel Antitumor Agents. Acs Medicinal Chemistry Letters. 12: 1948-1954. PMID 34917259 DOI: 10.1021/acsmedchemlett.1c00505 |
0.366 |
|
| 2021 |
Li J, Jiang X, Dick A, Prakash Sharma P, Chen CH, Rathi B, Kang D, Wang Z, Ji X, Lee KH, Cocklin S, Liu X, Zhan P. Design, synthesis, and antiviral activity of phenylalanine derivatives as HIV-1 capsid inhibitors. Bioorganic & Medicinal Chemistry. 48: 116414. PMID 34562701 DOI: 10.1016/j.bmc.2021.116414 |
0.307 |
|
| 2021 |
Zhang M, Otsuki K, Kikuchi T, Bai ZS, Zhou D, Huang L, Chen CH, Morris-Natschke SL, Lee KH, Li N, Koike K, Li W. LC-MS Identification, Isolation, and Structural Elucidation of Anti-HIV Tigliane Diterpenoids from . Journal of Natural Products. 84: 2366-2373. PMID 34445872 DOI: 10.1021/acs.jnatprod.1c00570 |
0.316 |
|
| 2021 |
Li QR, Cheng YY, Zhao L, Huang XL, Jiang XG, Cui YD, Morris-Natschke SL, Goto M, Chen CH, Lee KH, Chen DF, Zhang J. New Phorbol Ester Derivatives as Potent Anti-HIV Agents. Bioorganic & Medicinal Chemistry Letters. 128319. PMID 34403728 DOI: 10.1016/j.bmcl.2021.128319 |
0.723 |
|
| 2021 |
Zhang H, Jing L, Liu M, Goto M, Lai F, Liu X, Sheng L, Yang Y, Yang Y, Li Y, Chen X, Lee KH, Xiao Z. Identification of 3, 4-disubstituted pyridine derivatives as novel CDK8 inhibitors. European Journal of Medicinal Chemistry. 223: 113634. PMID 34147745 DOI: 10.1016/j.ejmech.2021.113634 |
0.6 |
|
| 2021 |
Niwa K, Tanaka N, Shimomoto Y, Tsuji D, Kim SY, Kojoma M, Itoh K, Chen CH, Lee KH, Kashiwada Y. Hyperdioxanes, dibenzo-1,4-dioxane derivatives from the roots of Hypericum ascyron. Journal of Natural Medicines. PMID 34142303 DOI: 10.1007/s11418-021-01540-y |
0.345 |
|
| 2021 |
Zhao Y, Chen CH, Morris-Natschke SL, Lee KH. Design, synthesis, and structure activity relationship analysis of new betulinic acid derivatives as potent HIV inhibitors. European Journal of Medicinal Chemistry. 215: 113287. PMID 33639343 DOI: 10.1016/j.ejmech.2021.113287 |
0.362 |
|
| 2020 |
Yin H, Zhang MJ, An RF, Zhou J, Liu W, Morris-Natschke SL, Cheng YY, Lee KH, Huang XF. Diosgenin Derivatives as Potential Antitumor Agents: Synthesis, Cytotoxicity, and Mechanism of Action. Journal of Natural Products. PMID 33381964 DOI: 10.1021/acs.jnatprod.0c00698 |
0.739 |
|
| 2020 |
Feng D, Zuo X, Jing L, Chen CH, Olotu FA, Lin H, Soliman M, De Clercq E, Pannecouque C, Lee KH, Kang D, Liu X, Zhan P. Design, synthesis, and evaluation of "dual-site"-binding diarylpyrimidines targeting both NNIBP and the NNRTI adjacent site of the HIV-1 reverse transcriptase. European Journal of Medicinal Chemistry. 211: 113063. PMID 33340914 DOI: 10.1016/j.ejmech.2020.113063 |
0.332 |
|
| 2020 |
Wang Q, Li Y, Zheng L, Huang X, Wang Y, Chen CH, Cheng YY, Morris-Natschke SL, Lee KH. Novel Betulinic Acid-Nucleoside Hybrids with Potent Anti-HIV Activity. Acs Medicinal Chemistry Letters. 11: 2290-2293. PMID 33214842 DOI: 10.1021/Acsmedchemlett.0C00414 |
0.744 |
|
| 2020 |
Otsuki K, Zhang M, Yamamoto A, Tsuji M, Tejima M, Bai ZS, Zhou D, Huang L, Chen CH, Lee KH, Li N, Li W, Koike K. Anti-HIV Tigliane Diterpenoids from . Journal of Natural Products. PMID 33172265 DOI: 10.1021/acs.jnatprod.0c00700 |
0.388 |
|
| 2020 |
Otsuki K, Li W, Miura K, Asada Y, Huang L, Chen CH, Lee KH, Koike K. Isolation, Structural Elucidation, and Anti-HIV Activity of Daphnane Diterpenoids from . Journal of Natural Products. PMID 32997496 DOI: 10.1021/acs.jnatprod.0c00540 |
0.368 |
|
| 2020 |
Rahim A, Saito Y, Fukuyoshi S, Miyake K, Goto M, Chen CH, Alam G, Lee KH, Nakagawa-Goto K. Paliasanines A-E, 3,4-Methylenedioxyquinoline Alkaloids Fused with a Phenyl-14-oxabicyclo[3.2.1]octane Unit from var. . Journal of Natural Products. PMID 32946697 DOI: 10.1021/Acs.Jnatprod.0C00454 |
0.518 |
|
| 2020 |
Wan Q, Jin X, Guo Y, Yu Z, Guo S, Morris-Natschke S, Lee KH, Liu H, Chen Y. New Seco-DSP derivatives as potent chemosensitizers. European Journal of Medicinal Chemistry. 204: 112555. PMID 32750634 DOI: 10.1016/J.Ejmech.2020.112555 |
0.456 |
|
| 2020 |
Qian J, Xu Z, Meng C, Liu J, Hsu PL, Li Y, Zhu W, Yang Y, Morris-Natschke SL, Lee KH, Zhang Y, Ling Y. Design and synthesis of benzylidenecyclohexenones as TrxR inhibitors displaying high anticancer activity and inducing ROS, apoptosis, and autophagy. European Journal of Medicinal Chemistry. 204: 112610. PMID 32736231 DOI: 10.1016/J.Ejmech.2020.112610 |
0.409 |
|
| 2020 |
Shang XF, Yang CJ, Morris-Natschke SL, Li JC, Yin XD, Liu YQ, Guo X, Peng JW, Goto M, Zhang JY, Lee KH. Biologically active isoquinoline alkaloids covering 2014-2018. Medicinal Research Reviews. PMID 32729169 DOI: 10.1002/Med.21703 |
0.397 |
|
| 2020 |
Zhang ZJ, Morris-Natschke SL, Cheng YY, Lee KH, Li RT. Development of anti-influenza agents from natural products. Medicinal Research Reviews. PMID 32677056 DOI: 10.1002/Med.21707 |
0.66 |
|
| 2020 |
Wu HF, Morris-Natschke SL, Xu XD, Yang MH, Cheng YY, Yu SS, Lee KH. Recent advances in natural anti-HIV triterpenoids and analogs. Medicinal Research Reviews. PMID 32666531 DOI: 10.1002/Med.21708 |
0.711 |
|
| 2020 |
Sun S, Huang B, Li Z, Wang Z, Sun L, Gao P, Kang D, Chen CH, Lee KH, Daelemans D, De Clercq E, Pannecouque C, Zhan P, Liu X. Discovery of potential dual-target prodrugs of HIV-1 reverse transcriptase and nucleocapsid protein 7. Bioorganic & Medicinal Chemistry Letters. 30: 127287. PMID 32631509 DOI: 10.1016/J.Bmcl.2020.127287 |
0.425 |
|
| 2020 |
Chang YT, Lin YC, Sun L, Liao WC, Wang CCN, Chou CY, Morris-Natschke SL, Lee KH, Hung CC. Wilforine resensitizes multidrug resistant cancer cells via competitive inhibition of P-glycoprotein. Phytomedicine : International Journal of Phytotherapy and Phytopharmacology. 71: 153239. PMID 32447245 DOI: 10.1016/J.Phymed.2020.153239 |
0.323 |
|
| 2020 |
Huang XL, Chen JL, Li XL, Zhao L, Cui YD, Liu JY, Morris-Natschke SL, Masuo G, Cheng YY, Lee KH, Chen DF, Zhang J. Synthesis and anticancer activities of biotinylated derivatives of glaucocalyxin A and oridonin. Journal of Asian Natural Products Research. 1-9. PMID 32441118 DOI: 10.1080/10286020.2020.1760851 |
0.705 |
|
| 2020 |
Liu Y, Qiu N, Shen L, Liu Q, Zhang J, Cheng YY, Lee KH, Huang L. Nanocarrier-mediated immunogenic chemotherapy for triple negative breast cancer. Journal of Controlled Release : Official Journal of the Controlled Release Society. PMID 32360890 DOI: 10.1016/J.Jconrel.2020.04.040 |
0.631 |
|
| 2020 |
Huang HT, Zhang LJ, Huang HC, Hwang SY, Wu CL, Lin YC, Liaw CC, Cheng YY, Morris-Natschke SL, Huang CY, Lee KH, Kuo YH. Cucurbitane-Type Triterpenoids from the Vines of and Their Anti-inflammatory Activities. Journal of Natural Products. PMID 32357011 DOI: 10.1021/Acs.Jnatprod.9B00592 |
0.701 |
|
| 2020 |
Yuan WH, Teng MT, Yun YF, Jiang N, Ma L, Sun SS, Yuan B, Tang J, Wu QY, Li Q, Zhang P, Morris-Natschke SL, Lee KH. Talarolactone A, an Isocoumarin Derivative Fused with Dihydrothiophene with Selective Antimigratory Activity from the Endolichenic Fungus sp. Journal of Natural Products. PMID 32315180 DOI: 10.1021/Acs.Jnatprod.0C00024 |
0.4 |
|
| 2020 |
Sun L, Dick A, Meuser ME, Huang T, Zalloum WAA, Chen CH, Cherukupalli S, Xu S, Ding X, Gao P, Kang D, De Clercq E, Pannecouque C, Cocklin S, Lee KH, et al. Design, Synthesis, and Mechanism Study of Benzenesulfonamide-containing Phenylalanine Derivatives as Novel HIV-1 Capsid Inhibitors with Improved Antiviral Activities. Journal of Medicinal Chemistry. PMID 32298111 DOI: 10.1021/Acs.Jmedchem.0C00015 |
0.46 |
|
| 2020 |
Lu Y, Huang YS, Chen CH, Akiyama T, Morris-Natschke SL, Cheng YY, Chen IS, Yang SZ, Chen DF, Lee KH. Anti-HIV tigliane diterpenoids from Reutealis trisperma. Phytochemistry. 174: 112360. PMID 32229336 DOI: 10.1016/J.Phytochem.2020.112360 |
0.722 |
|
| 2020 |
Sun L, Huang T, Dick A, Meuser ME, Zalloum WA, Chen CH, Ding X, Gao P, Cocklin S, Lee KH, Zhan P, Liu X. Design, synthesis and structure-activity relationships of 4-phenyl-1H-1,2,3-triazole phenylalanine derivatives as novel HIV-1 capsid inhibitors with promising antiviral activities. European Journal of Medicinal Chemistry. 190: 112085. PMID 32066010 DOI: 10.1016/J.Ejmech.2020.112085 |
0.404 |
|
| 2020 |
Lee DY, Hou YC, Yang JS, Lin HY, Chang TY, Lee KH, Kuo SC, Hsieh MT. Synthesis, Anticancer Activity, and Preliminary Pharmacokinetic Evaluation of 4,4-Disubstituted Curcuminoid 2,2-bis(Hydroxymethyl)Propionate Derivatives. Molecules (Basel, Switzerland). 25. PMID 31979200 DOI: 10.3390/Molecules25030479 |
0.496 |
|
| 2020 |
Jiang L, Goto M, Zhu DQ, Hsu PL, Li KP, Cui M, He X, Morris-Natschke SL, Lee KH, Xie L. Scaffold Hopping-Driven Optimization of 4-(Quinazolin-4-yl)-3,4-dihydroquinoxalin-2(1)-ones as Novel Tubulin Inhibitors. Acs Medicinal Chemistry Letters. 11: 83-89. PMID 31938468 DOI: 10.1021/Acsmedchemlett.9B00352 |
0.444 |
|
| 2020 |
Yang J, Chiang J, Tsai S, Hsu Y, Bau D, Lee K, Tsai F. In Silico De Novo Curcuminoid Derivatives From the Compound Library of Natural Products Research Laboratories Inhibit COVID-19 3CLpro Activity Natural Product Communications. 15. DOI: 10.1177/1934578X20953262 |
0.364 |
|
| 2019 |
Jiang X, Wu G, Zalloum WA, Meuser ME, Dick A, Sun L, Chen CH, Kang D, Jing L, Jia R, Cocklin S, Lee KH, Liu X, Zhan P. Discovery of novel 1,4-disubstituted 1,2,3-triazole phenylalanine derivatives as HIV-1 capsid inhibitors. Rsc Advances. 9: 28961-28986. PMID 32089839 DOI: 10.1039/C9Ra05869A |
0.488 |
|
| 2019 |
Yang JH, Wang XY, Zhou YP, Lu R, Chen CH, Zhang MH, Cheng YY, Morris-Natschke SL, Lee KH, Wang YS. Carbazole Alkaloids from : Isolation, Characterization, and Anti-HIV Evaluation. Molecules (Basel, Switzerland). 25. PMID 31888067 DOI: 10.3390/molecules25010099 |
0.7 |
|
| 2019 |
Yang CJ, Li B, Zhang ZJ, Gao JM, Wang MJ, Zhao XB, Song ZL, Liu YQ, Li H, Chen Y, Lee KH, Morris-Natschke SL, Xu C. Design, synthesis and antineoplastic activity of novel 20(S)-acylthiourea derivatives of camptothecin. European Journal of Medicinal Chemistry. 187: 111971. PMID 31881457 DOI: 10.1016/J.Ejmech.2019.111971 |
0.474 |
|
| 2019 |
Zhao HD, Lu Y, Yan M, Chen CH, Morris-Natschke SL, Lee KH, Chen DF. Rapid Recognition and Targeted Isolation of Anti-HIV Daphnane Diterpenes from Guided by UPLC-MS. Journal of Natural Products. PMID 31860304 DOI: 10.1021/Acs.Jnatprod.9B00993 |
0.427 |
|
| 2019 |
Wang GK, Zhang N, Yao JN, Yu Y, Wang G, Hung CC, Cheng YY, Morris-Natschke SL, Zhou ZY, Liu JS, Lee KH. Kalshinoids A-F, Anti-inflammatory Sesquiterpenes from . Journal of Natural Products. PMID 31804830 DOI: 10.1021/Acs.Jnatprod.9B00693 |
0.691 |
|
| 2019 |
Hsu TI, Chen YJ, Hung CY, Wang YC, Lin SJ, Su WC, Lai MD, Kim SY, Wang Q, Qian K, Goto M, Zhao Y, Kashiwada Y, Lee KH, Chang WC, et al. Correction: A novel derivative of betulinic acid, SYK023, suppresses lung cancer growth and malignancy. Oncotarget. 10: 6536-6537. PMID 31741716 DOI: 10.18632/Oncotarget.27297 |
0.454 |
|
| 2019 |
Chen Z, Huang KY, Ling Y, Goto M, Duan HQ, Tong XH, Liu YL, Cheng YY, Morris-Natschke SL, Yang PC, Yang SL, Lee KH. Discovery of an Oleanolic Acid/Hederagenin-Nitric Oxide Donor Hybrid as an EGFR Tyrosine Kinase Inhibitor for Non-Small-Cell Lung Cancer. Journal of Natural Products. PMID 31718182 DOI: 10.1021/Acs.Jnatprod.9B00659 |
0.718 |
|
| 2019 |
Aimaiti S, Saito Y, Fukuyoshi S, Goto M, Miyake K, Newman DJ, O'Keefe BR, Lee KH, Nakagawa-Goto K. Isolation, Structure Elucidation, and Antiproliferative Activity of Butanolides and Lignan Glycosides from the Fruit of . Molecules (Basel, Switzerland). 24. PMID 31694283 DOI: 10.3390/molecules24214005 |
0.341 |
|
| 2019 |
Otsuki K, Li W, Asada Y, Chen CH, Lee KH, Koike K. Daphneodorins A-C, Anti-HIV Gnidimacrin Related Macrocyclic Daphnane Orthoesters from . Organic Letters. PMID 31680527 DOI: 10.1021/Acs.Orglett.9B03539 |
0.469 |
|
| 2019 |
Miyake K, Morita C, Suzuki A, Matsushita N, Saito Y, Goto M, Newman DJ, O'Keefe BR, Lee KH, Nakagawa-Goto K. Prenylated Acetophloroglucinol Dimers from : Structure Elucidation and Total Synthesis. Journal of Natural Products. PMID 31550158 DOI: 10.1021/Acs.Jnatprod.9B00596 |
0.401 |
|
| 2019 |
Jing L, Wu G, Hao X, Olotu FA, Kang D, Chen CH, Lee KH, Soliman MES, Liu X, Song Y, Zhan P. Identification of highly potent and selective Cdc25 protein phosphatases inhibitors from miniaturization click-chemistry-based combinatorial libraries. European Journal of Medicinal Chemistry. 183: 111696. PMID 31541869 DOI: 10.1016/J.Ejmech.2019.111696 |
0.418 |
|
| 2019 |
Tsurumi F, Miura Y, Nakano M, Saito Y, Fukuyoshi S, Miyake K, Newman DJ, O'Keefe BR, Lee KH, Nakagawa-Goto K. Spiro[3.5]nonenyl Meroterpenoid Lactones, Cryptolaevilactones G-L, an Ionone Derivative, and Total Synthesis of Cryptolaevilactone M from . Journal of Natural Products. PMID 31442048 DOI: 10.1021/Acs.Jnatprod.8B00732 |
0.367 |
|
| 2019 |
Chang YT, Teng YN, Lin KI, Wang CCN, Morris-Natschke SL, Lee KH, Hung CC. Danazol mediates collateral sensitivity via STAT3/Myc related pathway in multidrug-resistant cancer cells. Scientific Reports. 9: 11628. PMID 31406162 DOI: 10.1038/S41598-019-48169-2 |
0.331 |
|
| 2019 |
Yamashita H, Miyao M, Hiramori K, Kobayashi D, Suzuki Y, Mizukami M, Goto M, Lee KH, Wada K. Cytotoxic diterpenoid alkaloid from Aconitum japonicum subsp. subcuneatum. Journal of Natural Medicines. PMID 31346973 DOI: 10.1007/S11418-019-01346-Z |
0.38 |
|
| 2019 |
Liu Q, Cheng YY, Li W, Huang L, Asada Y, Hsieh MT, Morris-Natschke SL, Chen CH, Koike K, Lee KH. Synthesis and Structure-Activity Relationship Correlations of Gnidimacrin Derivatives as Potent HIV-1 Inhibitors and HIV Latency Reversing Agents. Journal of Medicinal Chemistry. PMID 31343875 DOI: 10.1021/Acs.Jmedchem.9B00339 |
0.734 |
|
| 2019 |
Wada K, Goto M, Shimizu T, Kusanagi N, Mizukami M, Suzuki Y, Li KP, Lee KH, Yamashita H. Structure-activity relationships and evaluation of esterified diterpenoid alkaloid derivatives as antiproliferative agents. Journal of Natural Medicines. PMID 31222559 DOI: 10.1007/S11418-019-01331-6 |
0.343 |
|
| 2019 |
Zhou KS, Yi P, Yang T, Tian W, Yang FM, Lee KH, Zhao BY, Wang YH, Tan CJ. Ochrocephalamines B-D, Three Alkaloids from Oxytropis ochrocephala Bunge. Organic Letters. PMID 31199154 DOI: 10.1021/Acs.Orglett.9B01643 |
0.32 |
|
| 2019 |
Wang GK, Jin WF, Zhang N, Wang G, Cheng YY, Morris-Natschke SL, Goto M, Zhou ZY, Liu JS, Lee KH. Kalshiolin A, new lignan from . Journal of Asian Natural Products Research. 1-7. PMID 31190564 DOI: 10.1080/10286020.2019.1592164 |
0.708 |
|
| 2019 |
Huang YS, Lu Y, Chen CH, Lee KH, Chen DF. Potent Anti-HIV Ingenane Diterpenoids from Euphorbia ebracteolata. Journal of Natural Products. PMID 31184480 DOI: 10.1021/Acs.Jnatprod.9B00088 |
0.425 |
|
| 2019 |
Li J, Chang LC, Hsieh KY, Hsu PL, Capuzzi SJ, Zhang YC, Li KP, Morris-Natschke SL, Goto M, Lee KH. Design, synthesis and evaluation of antiproliferative activity of fluorinated betulinic acid. Bioorganic & Medicinal Chemistry. PMID 31126820 DOI: 10.1016/J.Bmc.2019.05.016 |
0.387 |
|
| 2019 |
Chen PY, Chang CC, Huang HC, Zhang LJ, Liaw CC, Lin YC, Nguyen NL, Vo TH, Cheng YY, Morris-Natschke SL, Lee KH, Kuo YH. New Dammarane-type Saponins from . Molecules (Basel, Switzerland). 24. PMID 30965662 DOI: 10.3390/molecules24071375 |
0.694 |
|
| 2019 |
Zhang Y, Goto M, Oda A, Hsu PL, Guo LL, Fu YH, Morris-Natschke SL, Hamel E, Lee KH, Hao XJ. Antiproliferative Aspidosperma-Type Monoterpenoid Indole Alkaloids from Inhibit Tubulin Polymerization. Molecules (Basel, Switzerland). 24. PMID 30935100 DOI: 10.3390/molecules24071256 |
0.308 |
|
| 2019 |
Song ZL, Yang GZ, Li JC, Liu YQ, Yang CJ, Goto M, Zhang ZJ, Morris-Natschke SL, Liu H, Lee KH. Design and synthesis of novel 7-[(N-substituted-thioureidopiperazinyl)-methyl]-camptothecin derivatives as potential cytotoxic agents. Natural Product Research. 1-8. PMID 30784310 DOI: 10.1080/14786419.2019.1573231 |
0.49 |
|
| 2019 |
Wu H, Ma G, Yang Q, Zhu Y, Huang L, Tian Y, Yang X, Zhang M, Chen CH, Morris-Natschke SL, Yang M, Xu X, Lee KH. Discovery and synthesis of novel beesioside I derivatives with potent anti-HIV activity. European Journal of Medicinal Chemistry. 166: 159-166. PMID 30703659 DOI: 10.1016/J.Ejmech.2019.01.020 |
0.498 |
|
| 2019 |
Kang D, Zhang H, Wang Z, Zhao T, Ginex T, Luque FJ, Yang Y, Wu G, Feng D, Wei F, Zhang J, De Clercq E, Pannecouque C, Chen CH, Lee KH, et al. Identification of Dihydrofuro[3,4-d]pyrimidine Derivatives as Novel HIV-1 Non-nucleoside Reverse Transcriptase Inhibitors with Promising Antiviral Activities and Desirable Physicochemical Properties. Journal of Medicinal Chemistry. PMID 30624934 DOI: 10.1021/Acs.Jmedchem.8B01656 |
0.455 |
|
| 2018 |
Chang YT, Wang CCN, Wang JY, Lee TE, Cheng YY, Morris-Natschke SL, Lee KH, Hung CC. Tenulin and isotenulin inhibit P-glycoprotein function and overcome multidrug resistance in cancer cells. Phytomedicine : International Journal of Phytotherapy and Phytopharmacology. 53: 252-262. PMID 30668405 DOI: 10.1016/J.Phymed.2018.09.008 |
0.66 |
|
| 2018 |
Gao P, Wang X, Sun L, Cheng X, Poongavanam V, Kongsted J, Álvarez M, Luczkowiak J, Pannecouque C, Clercq E, Lee KH, Chen CH, Liu H, Menéndez-Arias L, Liu X, et al. Design, Synthesis and Biological Evaluation of Novel Galloyl Derivatives as HIV-1 RNase H Inhibitors. Chemical Biology & Drug Design. PMID 30560566 DOI: 10.1111/Cbdd.13455 |
0.453 |
|
| 2018 |
Guo Y, Wang K, Chen X, Li H, Wan Q, Morris-Natschke S, Lee KH, Chen Y. Seco-4-methyl-DCK derivatives as potent chemosensitizers. Bioorganic & Medicinal Chemistry Letters. PMID 30455148 DOI: 10.1016/J.Bmcl.2018.11.023 |
0.466 |
|
| 2018 |
Zhao YF, Zhang YW, Wang Y, Morris-Natschke SL, Liu W, Shang TT, Yin H, Lee KH, Huang XF. New transformation pathway and cytotoxic derivatives from the acid hydrolysis of timosaponin B III. Natural Product Research. 1-7. PMID 30453752 DOI: 10.1080/14786419.2018.1499640 |
0.353 |
|
| 2018 |
Wu G, Zalloum WA, Meuser ME, Jing L, Kang D, Chen CH, Tian Y, Zhang F, Cocklin S, Lee KH, Liu X, Zhan P. Discovery of phenylalanine derivatives as potent HIV-1 capsid inhibitors from click chemistry-based compound library. European Journal of Medicinal Chemistry. 158: 478-492. PMID 30243152 DOI: 10.1016/J.Ejmech.2018.09.029 |
0.437 |
|
| 2018 |
Takeuchi M, Saito Y, Goto M, Miyake K, Newman DJ, O'Keefe BR, Lee KH, Nakagawa-Goto K. Antiproliferative Alkaloids from Alangium longiflorum, an Endangered Tropical Plant Species. Journal of Natural Products. PMID 30106296 DOI: 10.1021/Acs.Jnatprod.8B00411 |
0.428 |
|
| 2018 |
Liu Q, Li W, Huang L, Asada Y, Morris-Natschke SL, Chen CH, Lee KH, Koike K. Identification, structural modification, and dichotomous effects on human immunodeficiency virus type 1 (HIV-1) replication of ingenane esters from Euphorbia kansui. European Journal of Medicinal Chemistry. 156: 618-627. PMID 30031972 DOI: 10.1016/j.ejmech.2018.07.020 |
0.339 |
|
| 2018 |
Rahim A, Saito Y, Miyake K, Goto M, Chen CH, Alam G, Morris-Natschke S, Lee KH, Nakagawa-Goto K. Kleinhospitine E and Cycloartane Triterpenoids from Kleinhovia hospita. Journal of Natural Products. PMID 30010341 DOI: 10.1021/acs.jnatprod.8b00211 |
0.372 |
|
| 2018 |
Hsieh MT, Huang LJ, Wu TS, Lin HY, Morris-Natschke SL, Lee KH, Kuo SC. Synthesis and antitumor activity of bis(hydroxymethyl)propionate analogs of pterostilbene in cisplatin-resistant human oral cancer cells. Bioorganic & Medicinal Chemistry. PMID 29908756 DOI: 10.1016/j.bmc.2018.06.011 |
0.345 |
|
| 2018 |
Ling Y, Yang QX, Teng YN, Chen S, Gao WJ, Guo J, Hsu PL, Liu Y, Morris-Natschke SL, Hung CC, Lee KH. Development of novel amino-quinoline-5,8-dione derivatives as NAD(P)H:quinone oxidoreductase 1 (NQO1) inhibitors with potent antiproliferative activities. European Journal of Medicinal Chemistry. 154: 199-209. PMID 29803003 DOI: 10.1016/j.ejmech.2018.05.025 |
0.339 |
|
| 2018 |
Jing L, Tang Y, Goto M, Lee KH, Xiao Z. SAR study on ,-disubstituted pyrimidine-2,4-diamines as effective CDK2/CDK9 inhibitors and antiproliferative agents. Rsc Advances. 8: 11871-11885. PMID 29682280 DOI: 10.1039/C8Ra01440J |
0.588 |
|
| 2018 |
Tian Y, Liu Z, Liu J, Huang B, Kang D, Zhang H, De Clercq E, Daelemans D, Pannecouque C, Lee KH, Chen CH, Zhan P, Liu X. Targeting the entrance channel of NNIBP: Discovery of diarylnicotinamide 1,4-disubstituted 1,2,3-triazoles as novel HIV-1 NNRTIs with high potency against wild-type and E138K mutant virus. European Journal of Medicinal Chemistry. 151: 339-350. PMID 29635166 DOI: 10.1016/J.Ejmech.2018.03.059 |
0.48 |
|
| 2018 |
Zhang Y, Yuan YX, Goto M, Guo LL, Li XN, Morris-Natschke SL, Lee KH, Hao XJ. Taburnaemines A-I, Cytotoxic Vobasinyl-Iboga-Type Bisindole Alkaloids from Tabernaemontana corymbosa. Journal of Natural Products. PMID 29319316 DOI: 10.1021/acs.jnatprod.7b00949 |
0.308 |
|
| 2017 |
Zhao Y, Liu PY, Hsieh KY, Hsu PL, Goto M, Morris-Natschke SL, Harn HJ, Lee KH. Design, Synthesis and Structure-Activity Relationships of (±)-Isochaihulactone Derivatives. Medchemcomm. 8: 2040-2049. PMID 29391939 DOI: 10.1039/C7MD00310B |
0.327 |
|
| 2017 |
Chen Z, Duan H, Tong X, Hsu P, Han L, Morris-Natschke SL, Yang S, Liu W, Lee KH. Cytotoxicity, Hemolytic Toxicity, and Mechanism of Action of Pulsatilla Saponin D and Its Synthetic Derivatives. Journal of Natural Products. PMID 29131631 DOI: 10.1021/acs.jnatprod.7b00578 |
0.389 |
|
| 2017 |
Yang CJ, Song ZL, Goto M, Hsu PL, Zhang XS, Yang QR, Liu YQ, Wang MJ, Morris-Natschke SL, Shang XF, Lee KH. Design, semisynthesis and potent cytotoxic activity of novel 10-fluorocamptothecin derivatives. Bioorganic & Medicinal Chemistry Letters. PMID 28927790 DOI: 10.1016/j.bmcl.2017.09.012 |
0.354 |
|
| 2017 |
Shiau JY, Nakagawa-Goto K, Lee KH, Shyur LF. Phytoagent deoxyelephantopin derivative inhibits triple negative breast cancer cell activity by inducing oxidative stress-mediated paraptosis-like cell death. Oncotarget. 8: 56942-56958. PMID 28915644 DOI: 10.18632/Oncotarget.18183 |
0.38 |
|
| 2017 |
Yang CJ, Song ZL, Goto M, Liu YQ, Hsieh KY, Morris-Natschke SL, Zhao YL, Zhang JX, Lee KH. Design, synthesis, and cytotoxic activity of novel 7-substituted camptothecin derivatives incorporating piperazinyl-sulfonylamidine moieties. Bioorganic & Medicinal Chemistry Letters. PMID 28789891 DOI: 10.1016/j.bmcl.2017.07.078 |
0.359 |
|
| 2017 |
Zhou A, Yan L, Lai F, Chen X, Goto M, Lee KH, Xiao Z. Design, synthesis and biological evaluation of novel indolin-2-ones as potent anticancer compounds. Bioorganic & Medicinal Chemistry Letters. PMID 28625363 DOI: 10.1016/J.Bmcl.2017.06.019 |
0.567 |
|
| 2017 |
Luo P, Xia W, Morris-Natschke SL, Lee KH, Zhao Y, Gu Q, Xu J. Vitepyrroloids A-D, 2-Cyanopyrrole-Containing Labdane Diterpenoid Alkaloids from the Leaves of Vitex trifolia. Journal of Natural Products. PMID 28453270 DOI: 10.1021/acs.jnatprod.6b01195 |
0.323 |
|
| 2017 |
Hsieh MT, Chang LC, Hung HY, Lin HY, Shih MH, Tsai CH, Kuo SC, Lee KH. New bis(hydroxymethyl) alkanoate curcuminoid derivatives exhibit activity against triple-negative breast cancer in vitro and in vivo. European Journal of Medicinal Chemistry. 131: 141-151. PMID 28319780 DOI: 10.1016/j.ejmech.2017.03.006 |
0.584 |
|
| 2017 |
Zhu GX, Cheng PL, Goto M, Zhang N, Morris-Natschke SL, Hsieh KY, Yang GZ, Yang QR, Liu YQ, Chen HL, Zhang XS, Lee KH. Design, synthesis and potent cytotoxic activity of novel 7-(N-[(substituted-sulfonyl)piperazinyl]-methyl)-camptothecin derivatives. Bioorganic & Medicinal Chemistry Letters. PMID 28285912 DOI: 10.1016/j.bmcl.2017.02.066 |
0.376 |
|
| 2017 |
Vijaya Bhaskar Reddy M, Hung HY, Kuo PC, Huang GJ, Chan YY, Huang SC, Wu SJ, Morris-Natschke SL, Lee KH, Wu TS. Synthesis and biological evaluation of chalcone, dihydrochalcone, and 1,3-diarylpropane analogs as anti-inflammatory agents. Bioorganic & Medicinal Chemistry Letters. PMID 28256373 DOI: 10.1016/j.bmcl.2017.02.038 |
0.556 |
|
| 2017 |
Suzuki Y, Saito Y, Goto M, Newman DJ, O'Keefe BR, Lee KH, Nakagawa-Goto K. (-)-Neocaryachine, an Antiproliferative Pavine Alkaloid from Cryptocarya laevigata, Induces DNA Double-Strand Breaks. Journal of Natural Products. PMID 28099003 DOI: 10.1021/acs.jnatprod.6b01153 |
0.33 |
|
| 2016 |
Wada S, Tanaka N, Chen CH, Morris-Natschke SL, Lee KH, Kashiwada Y. Anti-HIV natural products (28): preparation of conjugate for 3-O-acyl betulin derivative and AZT as anti-HIV agents. Planta Medica. 81: S1-S381. PMID 27975981 DOI: 10.1055/S-0036-1596782 |
0.396 |
|
| 2016 |
Lin CH, Lee KH, Chen IS, Chang HS. Cytotoxic lignans from the fruits of Koelreuteria henryi. Planta Medica. 81: S1-S381. PMID 27975921 DOI: 10.1055/S-0036-1596722 |
0.355 |
|
| 2016 |
Morita C, Kobayashi Y, Saito Y, Miyake K, Tokuda H, Suzuki N, Ichiishi E, Lee KH, Nakagawa-Goto K. Total Synthesis and in Vitro Anti-Tumor-Promoting Activities of Racemic Acetophenone Monomers from Acronychia trifoliolata. Journal of Natural Products. 79: 2890-2897. PMID 27933896 DOI: 10.1021/acs.jnatprod.6b00646 |
0.345 |
|
| 2016 |
Miyake K, Suzuki A, Morita C, Goto M, Newman DJ, O'Keefe BR, Morris-Natschke SL, Lee KH, Nakagawa-Goto K. Acetophenone Monomers from Acronychia trifoliolata. Journal of Natural Products. PMID 27797192 DOI: 10.1021/acs.jnatprod.6b00645 |
0.343 |
|
| 2016 |
Nakagawa-Goto K, Taniguchi Y, Watanabe Y, Oda A, Ohkoshi E, Hamel E, Lee KH, Goto M. Triethylated chromones with substituted naphthalenes as tubulin inhibitors. Bioorganic & Medicinal Chemistry. PMID 27707623 DOI: 10.1016/j.bmc.2016.09.062 |
0.343 |
|
| 2016 |
Wang SB, Cui MT, Wang XF, Ohkoshi E, Goto M, Yang DX, Li L, Yuan S, Morris-Natschke SL, Lee KH, Xie L. Synthesis, biological evaluation, and physicochemical property assessment of 4-substituted 2-phenylaminoquinazolines as Mer tyrosine kinase inhibitors. Bioorganic & Medicinal Chemistry. PMID 27238842 DOI: 10.1016/j.bmc.2016.05.025 |
0.342 |
|
| 2016 |
Lee YB, Kim SJ, Park SM, Lee KH, Han HJ, Yu DS, Woo SY, Yun ST, Hamm SY, Kim HJ, Kim JW. Immunomodulatory Effects of Deokgu Thermomineral Water Balneotherapy on Oxazolone-Induced Atopic Dermatitis Murine Model. Annals of Dermatology. 28: 192-8. PMID 27081266 DOI: 10.5021/ad.2016.28.2.192 |
0.441 |
|
| 2016 |
Liu N, Wei L, Huang L, Yu F, Zheng W, Qin B, Zhu DQ, Morris-Natschke SL, Jiang S, Chen CH, Lee KH, Xie L. Novel HIV-1 Non-nucleoside Reverse Transcriptase Inhibitor Agents: Optimization of Diarylanilines with High Potency against Wild-Type and Rilpivirine-Resistant E138K Mutant Virus. Journal of Medicinal Chemistry. PMID 27070547 DOI: 10.1021/acs.jmedchem.5b01827 |
0.61 |
|
| 2016 |
Song ZL, Wang MJ, Li L, Wu D, Wang YH, Yan LT, Morris-Natschke SL, Liu YQ, Zhao YL, Wang CY, Liu H, Goto M, Liu H, Zhu GX, Lee KH. Design, synthesis, cytotoxic activity and molecular docking studies of new 20(S)-sulfonylamidine camptothecin derivatives. European Journal of Medicinal Chemistry. 115: 109-120. PMID 26994847 DOI: 10.1016/j.ejmech.2016.02.070 |
0.37 |
|
| 2016 |
Dang Z, Zhu L, Lai W, Bogerd H, Lee KH, Huang L, Chen CH. Aloperine and Its Derivatives as a New Class of HIV-1 Entry Inhibitors. Acs Medicinal Chemistry Letters. 7: 240-4. PMID 26985308 DOI: 10.1021/Acsmedchemlett.5B00339 |
0.425 |
|
| 2016 |
Shih HC, Kuo PC, Wu SJ, Hwang TL, Hung HY, Shen DY, Shieh PC, Liao YR, Lee EJ, Gu Q, Lee KH, Wu TS. Anti-inflammatory neolignans from the roots of Magnolia officinalis. Bioorganic & Medicinal Chemistry. PMID 26928286 DOI: 10.1016/J.Bmc.2016.01.049 |
0.597 |
|
| 2016 |
Lin YC, Chen YF, Tseng LS, Lee YH, Morris-Natschke SL, Kuo SC, Yang NS, Lee KH, Huang LJ. Synthesis and structure-activity relationship studies of novel 3,9-substituted α-carboline derivatives with high cytotoxic activity against colorectal cancer cells. European Journal of Medicinal Chemistry. 110: 98-114. PMID 26820553 DOI: 10.1016/j.ejmech.2016.01.004 |
0.384 |
|
| 2015 |
Tan CJ, Zhao Y, Goto M, Hsieh KY, Yang XM, Morris-Natschke SL, Liu LN, Zhao BY, Lee KH. Alkaloids from Oxytropis ochrocephala and antiproliferative activity of sophoridine derivatives against cancer cell lines. Bioorganic & Medicinal Chemistry Letters. PMID 26865176 DOI: 10.1016/j.bmcl.2015.09.010 |
0.348 |
|
| 2015 |
Li J, Goto M, Yang X, Morris-Natschke SL, Huang L, Chen CH, Lee KH. Fluorinated betulinic acid derivatives and evaluation of their anti-HIV activity. Bioorganic & Medicinal Chemistry Letters. PMID 26598461 DOI: 10.1016/J.Bmcl.2015.11.029 |
0.437 |
|
| 2015 |
Yan M, Lu Y, Chen CH, Zhao Y, Lee KH, Chen DF. Stelleralides D-J and Anti-HIV Daphnane Diterpenes from Stellera chamaejasme. Journal of Natural Products. PMID 26562066 DOI: 10.1021/acs.jnatprod.5b00660 |
0.356 |
|
| 2015 |
Xiao Z, Morris-Natschke SL, Lee KH. Strategies for the Optimization of Natural Leads to Anticancer Drugs or Drug Candidates. Medicinal Research Reviews. PMID 26359649 DOI: 10.1002/med.21377 |
0.482 |
|
| 2015 |
Fang HW, Liao YR, Hwang TL, Shieh PC, Lee KH, Hung HY, Wu TS. Total synthesis of cordatanine, structural reassignment of drymaritin, and anti-inflammatory activity of synthetic precursors. Bioorganic & Medicinal Chemistry Letters. PMID 26248804 DOI: 10.1016/j.bmcl.2015.07.074 |
0.554 |
|
| 2015 |
Wang SB, Wang XF, Qin B, Ohkoshi E, Hsieh KY, Hamel E, Cui MT, Zhu DQ, Goto M, Morris-Natschke SL, Lee KH, Xie L. Optimization of N-aryl-6-methoxy-1,2,3,4-tetrahydroquinolines as tubulin polymerization inhibitors. Bioorganic & Medicinal Chemistry. PMID 26242242 DOI: 10.1016/j.bmc.2015.07.016 |
0.326 |
|
| 2015 |
Song ZL, Chen HL, Wang YH, Goto M, Gao WJ, Cheng PL, Morris-Natschke SL, Liu YQ, Zhu GX, Wang MJ, Lee KH. Design and synthesis of novel PEG-conjugated 20(S)-camptothecin sulfonylamidine derivatives with potent in vitro antitumor activity via Cu-catalyzed three-component reaction. Bioorganic & Medicinal Chemistry Letters. 25: 2690-3. PMID 25987370 DOI: 10.1016/j.bmcl.2015.04.060 |
0.332 |
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| 2015 |
Gao J, Fang C, Xiao Z, Huang L, Chen CH, Wang LT, Lee KH. Discovery of novel 5-fluoro-N (2),N (4)-diphenylpyrimidine-2,4-diamines as potent inhibitors against CDK2 and CDK9. Medchemcomm. 6: 444-454. PMID 25914804 DOI: 10.1039/C4Md00412D |
0.692 |
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| 2015 |
Hsu TI, Chen YJ, Hung CY, Wang YC, Lin SJ, Su WC, Lai MD, Kim SY, Wang Q, Qian K, Goto M, Zhao Y, Kashiwada Y, Lee KH, Chang WC, et al. A novel derivative of betulinic acid, SYK023, suppresses lung cancer growth and malignancy. Oncotarget. 6: 13671-87. PMID 25909174 DOI: 10.18632/Oncotarget.3701 |
0.497 |
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| 2015 |
Liu YQ, Li WQ, Morris-Natschke SL, Qian K, Yang L, Zhu GX, Wu XB, Chen AL, Zhang SY, Nan X, Lee KH. Perspectives on Biologically Active Camptothecin Derivatives. Medicinal Research Reviews. 35: 753-89. PMID 25808858 DOI: 10.1002/Med.21342 |
0.553 |
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| 2015 |
Fang S, Chen L, Yu M, Cheng B, Lin Y, Morris-Natschke SL, Lee KH, Gu Q, Xu J. Synthesis, antitumor activity, and mechanism of action of 6-acrylic phenethyl ester-2-pyranone derivatives. Organic & Biomolecular Chemistry. 13: 4714-26. PMID 25800703 DOI: 10.1039/c5ob00007f |
0.407 |
|
| 2015 |
Wada K, Lee JY, Hung HY, Shi Q, Lin L, Zhao Y, Goto M, Yang PC, Kuo SC, Chen HW, Lee KH. Novel curcumin analogs to overcome EGFR-TKI lung adenocarcinoma drug resistance and reduce EGFR-TKI-induced GI adverse effects. Bioorganic & Medicinal Chemistry. 23: 1507-14. PMID 25753330 DOI: 10.1016/j.bmc.2015.02.003 |
0.557 |
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| 2015 |
Wu T, Wang Q, Jiang C, Morris-Natschke SL, Cui H, Wang Y, Yan Y, Xu J, Lee KH, Gu Q. Neo-clerodane diterpenoids from Scutellaria barbata with activity against Epstein-Barr virus lytic replication. Journal of Natural Products. 78: 500-9. PMID 25647077 DOI: 10.1021/np500988m |
0.306 |
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| 2015 |
Liu CY, Cheng YY, Chang LC, Huang LJ, Chou LC, Huang CH, Tsai MT, Liao CC, Hsu MH, Lin HY, Wu TS, Wen YF, Zhao Y, Kuo SC, Lee KH. Design and synthesis of new 2-arylnaphthyridin-4-ones as potent antitumor agents targeting tumorigenic cell lines. European Journal of Medicinal Chemistry. 90: 775-87. PMID 25528332 DOI: 10.1016/j.ejmech.2014.11.062 |
0.708 |
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| 2015 |
Liu YQ, Tian J, Qian K, Zhao XB, Morris-Natschke SL, Yang L, Nan X, Tian X, Lee KH. Recent progress on C-4-modified podophyllotoxin analogs as potent antitumor agents. Medicinal Research Reviews. 35: 1-62. PMID 24827545 DOI: 10.1002/Med.21319 |
0.583 |
|
| 2015 |
Feng J, Nakagawa-Goto K, Lee K, Shyur L. Abstract B175: A novel plant sesquiterpene lactone derivative DETD suppresses BRAFV600E mutant melanoma growth and overcomes acquired vemurafenib resistance in mice Molecular Cancer Therapeutics. 14. DOI: 10.1158/1535-7163.Targ-15-B175 |
0.379 |
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| 2015 |
Shiau J, Nakagawa-Goto K, Lee K, Lee W, Gervay-Hague J, Shyur L. Abstract A74: Modulation of oxidative stress and exosome activity by phytoagent deoxyelephantopin (DET) and its derivative treatment in suppressing triple negative breast cancer cell functions Molecular Cancer Therapeutics. 14. DOI: 10.1158/1535-7163.Targ-15-A74 |
0.372 |
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| 2015 |
Li XL, Gao LH, Li HM, Wang LT, Lee KH, Li RT. Diterpenoids from the stems of Tripterygium hypoglaucum (Celastraceae) and cytotoxic evaluation Phytochemistry Letters. 12: 84-89. DOI: 10.1016/J.Phytol.2015.02.018 |
0.368 |
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| 2014 |
Yang L, Nan X, Li WQ, Wang MJ, Zhao XB, Liu YQ, Zhang ZJ, Lee KH. Synthesis of novel spin-labeled podophyllotoxin derivatives as potential antineoplastic agents: Part XXV. Medicinal Chemistry Research : An International Journal For Rapid Communications On Design and Mechanisms of Action of Biologically Active Agents. 23: 4926-4931. PMID 25709376 DOI: 10.1007/s00044-014-1042-9 |
0.348 |
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| 2014 |
Zhao XB, Wu D, Wang MJ, Goto M, Morris-Natschke SL, Liu YQ, Wu XB, Song ZL, Zhu GX, Lee KH. Design and synthesis of novel spin-labeled camptothecin derivatives as potent cytotoxic agents. Bioorganic & Medicinal Chemistry. 22: 6453-8. PMID 25438769 DOI: 10.1016/j.bmc.2014.09.035 |
0.311 |
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| 2014 |
Gu W, Zhang Y, Hao XJ, Yang FM, Sun QY, Morris-Natschke SL, Lee KH, Wang YH, Long CL. Indole alkaloid glycosides from the aerial parts of Strobilanthes cusia. Journal of Natural Products. 77: 2590-4. PMID 25427242 DOI: 10.1021/Np5003274 |
0.4 |
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| 2014 |
Wu SY, Pan SL, Xiao ZY, Hsu JL, Chen MC, Lee KH, Teng CM. NPRL-Z-1, as a new topoisomerase II poison, induces cell apoptosis and ROS generation in human renal carcinoma cells. Plos One. 9: e112220. PMID 25372714 DOI: 10.1371/journal.pone.0112220 |
0.52 |
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| 2014 |
Wang YH, Goto M, Wang LT, Hsieh KY, Morris-Natschke SL, Tang GH, Long CL, Lee KH. Multidrug resistance-selective antiproliferative activity of Piper amide alkaloids and synthetic analogues. Bioorganic & Medicinal Chemistry Letters. 24: 4818-21. PMID 25241925 DOI: 10.1016/j.bmcl.2014.08.063 |
0.321 |
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| 2014 |
Liu WT, Chen C, Lu IC, Kuo SC, Lee KH, Chen TL, Song TS, Lu YL, Gean PW, Hour MJ. MJ-66 induces malignant glioma cells G2/M phase arrest and mitotic catastrophe through regulation of cyclin B1/Cdk1 complex. Neuropharmacology. 86: 219-27. PMID 25107587 DOI: 10.1016/J.Neuropharm.2014.07.014 |
0.301 |
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| 2014 |
Liu N, Qin B, Sun LQ, Yu F, Lu L, Jiang S, Lee KH, Xie L. Physicochemical property-driven optimization of diarylaniline compounds as potent HIV-1 non-nucleoside reverse transcriptase inhibitors Bioorganic and Medicinal Chemistry Letters. 24: 3719-3723. PMID 25042339 DOI: 10.1016/j.bmcl.2014.07.011 |
0.307 |
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| 2014 |
Zhao XB, Goto M, Song ZL, Morris-Natschke SL, Zhao Y, Wu D, Yang L, Li SG, Liu YQ, Zhu GX, Wu XB, Lee KH. Design and synthesis of new 7-(N-substituted-methyl)-camptothecin derivatives as potent cytotoxic agents. Bioorganic & Medicinal Chemistry Letters. 24: 3850-3. PMID 25008456 DOI: 10.1016/j.bmcl.2014.06.060 |
0.389 |
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| 2014 |
Wang MJ, Liu YQ, Chang LC, Wang CY, Zhao YL, Zhao XB, Qian K, Nan X, Yang L, Yang XM, Hung HY, Yang JS, Kuo DH, Goto M, Morris-Natschke SL, ... ... Lee KH, et al. Design, synthesis, mechanisms of action, and toxicity of novel 20(s)-sulfonylamidine derivatives of camptothecin as potent antitumor agents. Journal of Medicinal Chemistry. 57: 6008-18. PMID 25003995 DOI: 10.1021/Jm5003588 |
0.673 |
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| 2014 |
Wu ZY, Liu N, Qin B, Huang L, Yu F, Qian K, Morris-Natschke SL, Jiang S, Chen CH, Lee KH, Xie L. Optimization of the antiviral potency and lipophilicity of halogenated 2,6-diarylpyridinamines as a novel class of HIV-1 NNRTIS. Chemmedchem. 9: 1546-55. PMID 24895029 DOI: 10.1002/Cmdc.201400075 |
0.583 |
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| 2014 |
Shi LS, Kuo SC, Sun HD, Morris-Natschke SL, Lee KH, Wu TS. Cytotoxic cardiac glycosides and coumarins from Antiaris toxicaria. Bioorganic & Medicinal Chemistry. 22: 1889-98. PMID 24582402 DOI: 10.1016/j.bmc.2014.01.052 |
0.336 |
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| 2014 |
Kou L, Wang MJ, Wang LT, Zhao XB, Nan X, Yang L, Liu YQ, Morris-Natschke SL, Lee KH. Toward synthesis of third-generation spin-labeled podophyllotoxin derivatives using isocyanide multicomponent reactions. European Journal of Medicinal Chemistry. 75: 282-8. PMID 24553146 DOI: 10.1016/j.ejmech.2014.01.038 |
0.322 |
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| 2014 |
Wang XF, Guan F, Ohkoshi E, Guo W, Wang L, Zhu DQ, Wang SB, Wang LT, Hamel E, Yang D, Li L, Qian K, Morris-Natschke SL, Yuan S, Lee KH, et al. Optimization of 4-(N-cycloamino)phenylquinazolines as a novel class of tubulin-polymerization inhibitors targeting the colchicine site. Journal of Medicinal Chemistry. 57: 1390-402. PMID 24502232 DOI: 10.1021/Jm4016526 |
0.577 |
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| 2014 |
Chen CY, Yang SC, Lee KH, Yang X, Wei LY, Chow LP, Wang TC, Hong TM, Lin JC, Kuan C, Yang PC. The antitumor agent PBT-1 directly targets HSP90 and hnRNP A2/B1 and inhibits lung adenocarcinoma growth and metastasis. Journal of Medicinal Chemistry. 57: 677-85. PMID 24428777 DOI: 10.1021/jm401686b |
0.526 |
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| 2014 |
Hung HY, Nakagawa-Goto K, Tokuda H, Iida A, Suzuki N, Bori ID, Qian K, Lee KH. A-ring modified betulinic acid derivatives as potent cancer preventive agents. Bioorganic & Medicinal Chemistry Letters. 24: 1005-8. PMID 24411124 DOI: 10.1016/J.Bmcl.2013.12.041 |
0.711 |
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| 2014 |
Zhang ZJ, Tian J, Wang LT, Wang MJ, Nan X, Yang L, Liu YQ, Morris-Natschke SL, Lee KH. Design, synthesis and cytotoxic activity of novel sulfonylurea derivatives of podophyllotoxin. Bioorganic & Medicinal Chemistry. 22: 204-10. PMID 24332656 DOI: 10.1016/j.bmc.2013.11.035 |
0.381 |
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| 2014 |
Yu FL, He XY, Gu C, Ohkoshi E, Wang LT, Wang SB, Lai CY, Yu L, Morris-Natschke SL, Lee KH, Liu S, Xie L. Discovery of novel antitumor dibenzocyclooctatetraene derivatives and related biphenyls as potent inhibitors of NF-κB signaling pathway. Bioorganic & Medicinal Chemistry. 22: 325-33. PMID 24315191 DOI: 10.1016/j.bmc.2013.11.018 |
0.309 |
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| 2014 |
Qin J, Li HM, Gao LH, Liu D, Li RT, Lee K. New labdane diterpenoids from Leonurus japonicus and their anti-inflammatory activity Phytochemistry Letters. 10: 313-317. DOI: 10.1016/J.Phytol.2014.10.027 |
0.447 |
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| 2013 |
Li RJ, Zhu RX, Li YY, Zhou JC, Zhang JZ, Wang S, Ye JP, Wang YH, Morris-Natschke SL, Lee KH, Lou HX. Secondary metabolites from the Chinese liverwort Cephaloziella kiaeri. Journal of Natural Products. 76: 1700-8. PMID 24033150 DOI: 10.1021/Np400426A |
0.358 |
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| 2013 |
Cheng YY, Liu CY, Tsai MT, Lin HY, Yang JS, Wu TS, Kuo SC, Huang LJ, Lee KH. Design, synthesis, and mechanism of action of 2-(3-hydroxy-5-methoxyphenyl)-6-pyrrolidinylquinolin-4-one as a potent anticancer lead. Bioorganic & Medicinal Chemistry Letters. 23: 5223-7. PMID 23916255 DOI: 10.1016/j.bmcl.2013.06.083 |
0.721 |
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| 2013 |
Cheng YY, Liu CY, Huang LJ, Huang CH, Lee KH, Lin CT, Kuo SC. Mechanistic studies on regioselective dephosphorylation of phosphate prodrugs during a facile synthesis of antitumor phosphorylated 2-phenyl-6,7-methylenedioxy-1H-quinolin-4-one. Molecules (Basel, Switzerland). 18: 8028-45. PMID 23884134 DOI: 10.3390/molecules18078028 |
0.636 |
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| 2013 |
Wang XF, Wang SB, Ohkoshi E, Wang LT, Hamel E, Qian K, Morris-Natschke SL, Lee KH, Xie L. N-aryl-6-methoxy-1,2,3,4-tetrahydroquinolines: a novel class of antitumor agents targeting the colchicine site on tubulin. European Journal of Medicinal Chemistry. 67: 196-207. PMID 23867604 DOI: 10.1016/J.Ejmech.2013.06.041 |
0.608 |
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| 2013 |
Chen YF, Lin YC, Huang PK, Chan HC, Kuo SC, Lee KH, Huang LJ. Design and synthesis of 6,7-methylenedioxy-4-substituted phenylquinolin-2(1H)-one derivatives as novel anticancer agents that induce apoptosis with cell cycle arrest at G2/M phase. Bioorganic & Medicinal Chemistry. 21: 5064-75. PMID 23867385 DOI: 10.1016/j.bmc.2013.06.046 |
0.325 |
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| 2013 |
Wei S, Tang YB, Hua H, Ohkoshi E, Goto M, Wang LT, Lee KH, Xiao Z. Discovery of novel andrographolide derivatives as cytotoxic agents. Bioorganic & Medicinal Chemistry Letters. 23: 4056-60. PMID 23768904 DOI: 10.1016/J.Bmcl.2013.05.061 |
0.601 |
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| 2013 |
Zhao Y, Su J, Goto M, Morris-Natschke SL, Li Y, Zhao QS, Yao ZJ, Lee KH. Dual-functional abeo-taxane derivatives destabilizing microtubule equilibrium and inhibiting NF-κB activation. Journal of Medicinal Chemistry. 56: 4749-57. PMID 23725535 DOI: 10.1021/jm400479p |
0.371 |
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| 2013 |
Shih HC, Hwang TL, Chen HC, Kuo PC, Lee EJ, Lee KH, Wu TS. Honokiol dimers and magnolol derivatives with new carbon skeletons from the roots of Magnolia officinalis and their inhibitory effects on superoxide anion generation and elastase release. Plos One. 8: e59502. PMID 23667420 DOI: 10.1371/Journal.Pone.0059502 |
0.36 |
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| 2013 |
Asada Y, Sukemori A, Watanabe T, Malla KJ, Yoshikawa T, Li W, Kuang X, Koike K, Chen CH, Akiyama T, Qian K, Nakagawa-Goto K, Morris-Natschke SL, Lu Y, Lee KH. Isolation, structure determination, and anti-HIV evaluation of tigliane-type diterpenes and biflavonoid from Stellera chamaejasme. Journal of Natural Products. 76: 852-7. PMID 23611151 DOI: 10.1021/Np300815T |
0.631 |
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| 2013 |
Li WQ, Wang XL, Qian K, Liu YQ, Wang CY, Yang L, Tian J, Morris-Natschke SL, Zhou XW, Lee KH. Design, synthesis and potent cytotoxic activity of novel podophyllotoxin derivatives. Bioorganic & Medicinal Chemistry. 21: 2363-9. PMID 23490151 DOI: 10.1016/J.Bmc.2013.01.069 |
0.603 |
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| 2013 |
Chen M, Xu X, Xu B, Yang P, Liao Z, Morris-Natschke SL, Lee KH, Chen D. Neglschisandrins E-F: two new lignans and related cytotoxic lignans from Schisandra neglecta. Molecules (Basel, Switzerland). 18: 2297-306. PMID 23429345 DOI: 10.3390/Molecules18022297 |
0.417 |
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| 2013 |
Dang Z, Ho P, Zhu L, Qian K, Lee KH, Huang L, Chen CH. New betulinic acid derivatives for bevirimat-resistant human immunodeficiency virus type-1. Journal of Medicinal Chemistry. 56: 2029-37. PMID 23379607 DOI: 10.1021/Jm3016969 |
0.583 |
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| 2013 |
Liu YQ, Li XJ, Zhao CY, Nan X, Tian J, Morris-Natschke SL, Zhang ZJ, Yang XM, Yang L, Li LH, Zhou XW, Lee KH. Synthesis and mechanistic studies of novel spin-labeled combretastatin derivatives as potential antineoplastic agents. Bioorganic & Medicinal Chemistry. 21: 1248-56. PMID 23369687 DOI: 10.1016/J.Bmc.2012.12.046 |
0.462 |
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| 2013 |
Wang XF, Ohkoshi E, Wang SB, Hamel E, Bastow KF, Morris-Natschke SL, Lee KH, Xie L. Synthesis and biological evaluation of N-alkyl-N-(4-methoxyphenyl)pyridin-2-amines as a new class of tubulin polymerization inhibitors. Bioorganic & Medicinal Chemistry. 21: 632-42. PMID 23274123 DOI: 10.1016/j.bmc.2012.11.047 |
0.33 |
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| 2013 |
Huang SM, Cheng YY, Chen MH, Huang CH, Huang LJ, Hsu MH, Kuo SC, Lee KH. Design and synthesis of 2-(3-alkylaminophenyl)-6-(pyrrolidin-1-yl)quinolin-4-ones as potent antitumor agents. Bioorganic & Medicinal Chemistry Letters. 23: 699-701. PMID 23260351 DOI: 10.1016/j.bmcl.2012.11.105 |
0.729 |
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| 2013 |
Wada K, Ohkoshi E, Bastow K, Lee K. New Advances with C20-Diterpenoid Alkaloids as Anticancer Agents Planta Medica. 79. DOI: 10.1055/S-0033-1348560 |
0.326 |
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| 2012 |
Lee KH, Morris-Natschke S, Qian K, Dong Y, Yang X, Zhou T, Belding E, Wu SF, Wada K, Akiyama T. Recent Progress of Research on Herbal Products Used in Traditional Chinese Medicine: the Herbs belonging to The Divine Husbandman's Herbal Foundation Canon ( Shén Nóng Běn Cǎo Jīng). Journal of Traditional and Complementary Medicine. 2: 6-26. PMID 24716110 DOI: 10.1016/S2225-4110(16)30066-9 |
0.59 |
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| 2012 |
Guo H, Zhuang X, Qian K, Sun L, Wang X, Li H, Lee K, Xie L. Prodrug design, synthesis and pharmacokinetic evaluation of (3' R, 4' R)-3-hydroxymethyl-4-methyl-3',4'-di-O-(S)-camphanoyl-(+)-cis-khellactone. Acta Pharmaceutica Sinica. B. 2: 213-219. PMID 23687633 DOI: 10.1016/J.Apsb.2012.02.008 |
0.617 |
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| 2012 |
Dang Z, Jung K, Qian K, Lee KH, Huang L, Chen CH. Synthesis of Lithocholic Acid Derivatives as Proteasome Regulators. Acs Medicinal Chemistry Letters. 3: 925-930. PMID 23330053 DOI: 10.1021/Ml3001962 |
0.532 |
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| 2012 |
Wang Y, Wong HC, Gullen EA, Lam W, Yang X, Shi Q, Lee KH, Cheng YC. Cryptopleurine analogs with modification of e ring exhibit different mechanism to rac-cryptopleurine and tylophorine. Plos One. 7: e51138. PMID 23251437 DOI: 10.1371/journal.pone.0051138 |
0.309 |
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| 2012 |
Hung HY, Ohkoshi E, Goto M, Nakagawa-Goto K, Lee KH. 1-(3,4,5-Trimethoxyphenyl)ethane-1,2-diyl esters, a novel compound class with potent chemoreversal activity. Bioorganic & Medicinal Chemistry Letters. 22: 7726-9. PMID 23122817 DOI: 10.1016/j.bmcl.2012.09.096 |
0.589 |
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| 2012 |
Liu Y, Qian K, Wang CY, Chen CH, Yang X, Lee KH. Synthesis and biological evaluation of novel spin labeled 18β-glycyrrhetinic acid derivatives. Bioorganic & Medicinal Chemistry Letters. 22: 7530-3. PMID 23122524 DOI: 10.1016/J.Bmcl.2012.10.041 |
0.562 |
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| 2012 |
Liu YQ, Dai W, Wang CY, Morris-Natschke SL, Zhou XW, Yang L, Yang XM, Li WQ, Lee KH. Design and one-pot synthesis of new 7-acyl camptothecin derivatives as potent cytotoxic agents. Bioorganic & Medicinal Chemistry Letters. 22: 7659-61. PMID 23102893 DOI: 10.1016/j.bmcl.2012.10.002 |
0.355 |
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| 2012 |
Qian K, Bori ID, Chen CH, Huang L, Lee KH. Anti-AIDS agents 90. novel C-28 modified bevirimat analogues as potent HIV maturation inhibitors. Journal of Medicinal Chemistry. 55: 8128-36. PMID 22978745 DOI: 10.1021/Jm301040S |
0.629 |
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| 2012 |
Wang XF, Tian XT, Ohkoshi E, Qin B, Liu YN, Wu PC, Hour MJ, Hung HY, Qian K, Huang R, Bastow KF, Janzen WP, Jin J, Morris-Natschke SL, Lee KH, et al. Design and synthesis of diarylamines and diarylethers as cytotoxic antitumor agents. Bioorganic & Medicinal Chemistry Letters. 22: 6224-8. PMID 22932313 DOI: 10.1016/J.Bmcl.2012.08.014 |
0.713 |
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| 2012 |
Sun LQ, Zhu L, Qian K, Qin B, Huang L, Chen CH, Lee KH, Xie L. Design, synthesis, and preclinical evaluations of novel 4-substituted 1,5-diarylanilines as potent HIV-1 non-nucleoside reverse transcriptase inhibitor (NNRTI) drug candidates. Journal of Medicinal Chemistry. 55: 7219-29. PMID 22856541 DOI: 10.1021/Jm3007678 |
0.595 |
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| 2012 |
Cheng YY, Yang JS, Tsai SC, Liaw CC, Chung JG, Huang LJ, Lee KH, Lu CC, Chien HC, Tsuzuki M, Kuo SC. The newly synthesized 2-(3-hydroxy-5-methoxyphenyl)-6,7-methylenedioxyquinolin-4-one triggers cell apoptosis through induction of oxidative stress and upregulation of the p38 MAPK signaling pathway in HL-60 human leukemia cells. Oncology Reports. 28: 1482-90. PMID 22825350 DOI: 10.3892/or.2012.1923 |
0.631 |
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| 2012 |
Yang X, Shi Q, Lai CY, Chen CY, Ohkoshi E, Yang SC, Wang CY, Bastow KF, Wu TS, Pan SL, Teng CM, Yang PC, Lee KH. Antitumor agents 295. E-ring hydroxylated antofine and cryptopleurine analogues as antiproliferative agents: design, synthesis, and mechanistic studies. Journal of Medicinal Chemistry. 55: 6751-61. PMID 22823514 DOI: 10.1021/jm3001218 |
0.333 |
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| 2012 |
Dang Z, Qian K, Ho P, Zhu L, Lee KH, Huang L, Chen CH. Synthesis of betulinic acid derivatives as entry inhibitors against HIV-1 and bevirimat-resistant HIV-1 variants. Bioorganic & Medicinal Chemistry Letters. 22: 5190-4. PMID 22818973 DOI: 10.1016/J.Bmcl.2012.06.080 |
0.567 |
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| 2012 |
Lin AS, Nakagawa-Goto K, Chang FR, Yu D, Morris-Natschke SL, Wu CC, Chen SL, Wu YC, Lee KH. Correction to first total synthesis of protoapigenone and its analogues as potent cytotoxic agents. Journal of Medicinal Chemistry. 55: 6985. PMID 22817473 DOI: 10.1021/Jm300948P |
0.544 |
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| 2012 |
Wu TS, Sun CR, Lee KH. Cytotoxic and anti-HIV phenanthroindolizidine alkaloids from Cryptocarya chinensis. Natural Product Communications. 7: 725-7. PMID 22816292 |
0.405 |
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| 2012 |
Wang LT, Pan SL, Chen TH, Dong Y, Lee KH, Teng CM. DYZ-2-90, a novel neo-tanshinlactone ring-opened compound, induces ERK-mediated mitotic arrest and subsequent apoptosis by activating JNK in human colorectal cancer cells. Chembiochem : a European Journal of Chemical Biology. 13: 1663-72. PMID 22761044 DOI: 10.1002/Cbic.201200191 |
0.578 |
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| 2012 |
Bori ID, Hung HY, Qian K, Chen CH, Morris-Natschke SL, Lee KH. Anti-AIDS agents 88. Anti-HIV conjugates of betulin and betulinic acid with AZT prepared via click chemistry. Tetrahedron Letters. 53: 1987-1989. PMID 22711941 DOI: 10.1016/J.Tetlet.2012.02.022 |
0.716 |
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| 2012 |
Li J, Hua HM, Tang YB, Zhang S, Ohkoshi E, Lee KH, Xiao Zy. Synthesis and evaluation of novel podophyllotoxin analogs. Bioorganic & Medicinal Chemistry Letters. 22: 4293-5. PMID 22658864 DOI: 10.1016/J.Bmcl.2012.05.033 |
0.654 |
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| 2012 |
Hung HY, Ohkoshi E, Goto M, Bastow KF, Nakagawa-Goto K, Lee KH. Antitumor agents. 293. Nontoxic dimethyl-4,4'-dimethoxy-5,6,5',6'-dimethylenedioxybiphenyl-2,2'-dicarboxylate (DDB) analogues chemosensitize multidrug-resistant cancer cells to clinical anticancer drugs. Journal of Medicinal Chemistry. 55: 5413-24. PMID 22612652 DOI: 10.1021/jm300378k |
0.574 |
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| 2012 |
Yen CT, Nakagawa-Goto K, Hwang TL, Morris-Natschke SL, Bastow KF, Wu YC, Lee KH. Design and synthesis of gambogic acid analogs as potent cytotoxic and anti-inflammatory agents. Bioorganic & Medicinal Chemistry Letters. 22: 4018-22. PMID 22595179 DOI: 10.1016/j.bmcl.2012.04.084 |
0.33 |
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| 2012 |
Hung HY, Qian K, Morris-Natschke SL, Hsu CS, Lee KH. Recent discovery of plant-derived anti-diabetic natural products. Natural Product Reports. 29: 580-606. PMID 22491825 DOI: 10.1039/C2Np00074A |
0.609 |
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| 2012 |
Zhou T, Ohkoshi E, Shi Q, Bastow KF, Lee KH. Anti-AIDS agents 89. Identification of DCX derivatives as anti-HIV and chemosensitizing dual function agents to overcome P-gp-mediated drug resistance for AIDS therapy. Bioorganic & Medicinal Chemistry Letters. 22: 3219-22. PMID 22465634 DOI: 10.1016/j.bmcl.2012.03.037 |
0.305 |
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| 2012 |
Xu K, Xiao Z, Tang YB, Huang L, Chen CH, Ohkoshi E, Lee KH. Design and synthesis of naphthoquinone derivatives as antiproliferative agents and 20S proteasome inhibitors. Bioorganic & Medicinal Chemistry Letters. 22: 2772-4. PMID 22437113 DOI: 10.1016/J.Bmcl.2012.02.086 |
0.617 |
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| 2012 |
Sun LQ, Qin B, Huang L, Qian K, Chen CH, Lee KH, Xie L. Optimization of 2,4-diarylanilines as non-nucleoside HIV-1 reverse transcriptase inhibitors. Bioorganic & Medicinal Chemistry Letters. 22: 2376-9. PMID 22406117 DOI: 10.1016/J.Bmcl.2012.02.055 |
0.589 |
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| 2012 |
Huang HC, Chiou CT, Hsiao PC, Liaw CC, Zhang LJ, Chang CL, Chen IS, Chen WC, Lee KH, Kuo YH. Cytotoxic phenylpropanoids and a new triterpene, turformosinic acid, from Turpinia formosana Nakai. Molecules (Basel, Switzerland). 17: 1837-51. PMID 22334062 DOI: 10.3390/molecules17021837 |
0.313 |
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| 2012 |
Dong Y, Nakagawa-Goto K, Lai CY, Morris-Natschke SL, Bastow KF, Kim Y, Lee EY, Lee KH. Antitumor agents. 289. Design, synthesis, and anti-breast cancer activity in vivo of 4-amino-2H-benzo[h]chromen-2-one and 4-amino-7,8,9,10-tetrahydro-2H-benzo[h]chromen-2-one analogues with improved water solubility. Journal of Natural Products. 75: 370-7. PMID 22304236 DOI: 10.1021/Np2007878 |
0.568 |
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| 2012 |
Chen Y, Liu HR, Liu HS, Cheng M, Xia P, Qian K, Wu PC, Lai CY, Xia Y, Yang ZY, Morris-Natschke SL, Lee KH. Antitumor agents 292. Design, synthesis and pharmacological study of S- and O-substituted 7-mercapto- or hydroxy-coumarins and chromones as potent cytotoxic agents. European Journal of Medicinal Chemistry. 49: 74-85. PMID 22265685 DOI: 10.1016/J.Ejmech.2011.12.025 |
0.628 |
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| 2012 |
Liu YQ, Ohkoshi E, Li LH, Yang L, Lee KH. Design, synthesis and cytotoxic activity of novel spin-labeled rotenone derivatives. Bioorganic & Medicinal Chemistry Letters. 22: 920-3. PMID 22204911 DOI: 10.1016/j.bmcl.2011.12.024 |
0.342 |
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| 2012 |
Hung HY, Nakagawa-Goto K, Tokuda H, Iida A, Suzuki N, Morris-Natschke SL, Lee KH. Cancer preventive agents 11. Novel analogs of dimethyl dicarboxylate biphenyl as potent cancer chemopreventive agents(†). Pharmaceutical Biology. 50: 18-24. PMID 22196579 DOI: 10.3109/13880209.2011.608078 |
0.537 |
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| 2012 |
Wada K, Ohkoshi E, Morris-Natschke SL, Bastow KF, Lee KH. Cytotoxic esterified diterpenoid alkaloid derivatives with increased selectivity against a drug-resistant cancer cell line. Bioorganic & Medicinal Chemistry Letters. 22: 249-52. PMID 22142543 DOI: 10.1055/S-0032-1320369 |
0.427 |
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| 2012 |
Vijaya Bhaskar Reddy M, Shen YC, Ohkoshi E, Bastow KF, Qian K, Lee KH, Wu TS. Bis-chalcone analogues as potent NO production inhibitors and as cytotoxic agents. European Journal of Medicinal Chemistry. 47: 97-103. PMID 22115618 DOI: 10.1016/J.Ejmech.2011.10.026 |
0.629 |
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| 2012 |
Zhou T, Shi Q, Chen CH, Huang L, Ho P, Morris-Natschke SL, Lee KH. Anti-AIDS agents 85. Design, synthesis, and evaluation of 1R,2R-dicamphanoyl-3,3-dimethyldihydropyrano-[2,3-c]xanthen-7(1H)-one (DCX) derivatives as novel anti-HIV agents. European Journal of Medicinal Chemistry. 47: 86-96. PMID 22063755 DOI: 10.1016/j.ejmech.2011.10.025 |
0.362 |
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| 2012 |
Chen MC, Pan SL, Shi Q, Xiao Z, Lee KH, Li TK, Teng CM. QS-ZYX-1-61 induces apoptosis through topoisomerase II in human non-small-cell lung cancer A549 cells. Cancer Science. 103: 80-7. PMID 21920000 DOI: 10.1111/j.1349-7006.2011.02103.x |
0.5 |
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| 2011 |
Nakagawa-Goto K, Bastow KF, Ohkoshi E, Morris-Natschke SL, Lee KH. Antitumor Agents 291 Expanded B-Ring Modification Study of 6,8,8-Triethyl Desmosdumotin B Analogues as Multidrug-Resistance Selective Agents. Medicinal Chemistry. 1. PMID 23293751 DOI: 10.4172/2161-0444.1000101 |
0.437 |
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| 2011 |
Vijaya Bhaskar Reddy M, Tsai WJ, Qian K, Lee KH, Wu TS. Structure-activity relationships of chalcone analogs as potential inhibitors of ADP- and collagen-induced platelet aggregation. Bioorganic & Medicinal Chemistry. 19: 7711-9. PMID 22055718 DOI: 10.1016/J.Bmc.2011.08.004 |
0.518 |
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| 2011 |
Chen CT, Hsu MH, Cheng YY, Liu CY, Chou LC, Huang LJ, Wu TS, Yang X, Lee KH, Kuo SC. Synthesis and in vitro anticancer activity of 6,7-methylenedioxy (or 5-hydroxy-6-methoxy)-2-(substituted selenophenyl)quinolin-4-one analogs. European Journal of Medicinal Chemistry. 46: 6046-56. PMID 22030314 DOI: 10.1016/j.ejmech.2011.10.017 |
0.729 |
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| 2011 |
Kurimoto S, Kashiwada Y, Lee KH, Takaishi Y. Triterpenes and a triterpene glucoside from Dysoxylum cumingianum. Phytochemistry. 72: 2205-11. PMID 21899865 DOI: 10.1016/j.phytochem.2011.08.002 |
0.302 |
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| 2011 |
Liu HS, Xu SQ, Cheng M, Chen Y, Xia P, Qian K, Xia Y, Yang ZY, Chen CH, Morris-Natschke SL, Lee KH. Anti-AIDS agents 87. New bio-isosteric dicamphanoyl-dihydropyranochromone (DCP) and dicamphanoyl-khellactone (DCK) analogues with potent anti-HIV activity. Bioorganic & Medicinal Chemistry Letters. 21: 5831-4. PMID 21871800 DOI: 10.1016/J.Bmcl.2011.07.105 |
0.588 |
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| 2011 |
Chen Y, Cheng M, Liu FQ, Xia P, Qian K, Yu D, Xia Y, Yang ZY, Chen CH, Morris-Natschke SL, Lee KH. Anti-AIDS agents 86. Synthesis and anti-HIV evaluation of 2',3'-seco-3'-nor DCP and DCK analogues. European Journal of Medicinal Chemistry. 46: 4924-36. PMID 21864952 DOI: 10.1016/J.Ejmech.2011.07.051 |
0.733 |
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| 2011 |
Qian K, Kim SY, Hung HY, Huang L, Chen CH, Lee KH. New betulinic acid derivatives as potent proteasome inhibitors. Bioorganic & Medicinal Chemistry Letters. 21: 5944-7. PMID 21856154 DOI: 10.1016/J.Bmcl.2011.07.072 |
0.698 |
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| 2011 |
Wang Q, Hu W, Wang S, Pan Z, Tao L, Guo X, Qian K, Chen CH, Lee KH, Chang J. Synthesis of new 2'-deoxy-2'-fluoro-4'-azido nucleoside analogues as potent anti-HIV agents. European Journal of Medicinal Chemistry. 46: 4178-83. PMID 21745701 DOI: 10.1016/J.Ejmech.2011.06.020 |
0.638 |
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| 2011 |
Yang X, Shi Q, Yang SC, Chen CY, Yu SL, Bastow KF, Morris-Natschke SL, Wu PC, Lai CY, Wu TS, Pan SL, Teng CM, Lin JC, Yang PC, Lee KH. Antitumor agents 288: design, synthesis, SAR, and biological studies of novel heteroatom-incorporated antofine and cryptopleurine analogues as potent and selective antitumor agents. Journal of Medicinal Chemistry. 54: 5097-107. PMID 21668000 DOI: 10.1021/jm200330s |
0.358 |
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| 2011 |
Asada Y, Sukemori A, Watanabe T, Malla KJ, Yoshikawa T, Li W, Koike K, Chen CH, Akiyama T, Qian K, Nakagawa-Goto K, Morris-Natschke SL, Lee KH. Stelleralides A-C, novel potent anti-HIV daphnane-type diterpenoids from Stellera chamaejasme L. Organic Letters. 13: 2904-7. PMID 21561135 DOI: 10.1021/Ol200889S |
0.626 |
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| 2011 |
Dong Y, Nakagawa-Goto K, Lai CY, Morris-Natschke SL, Bastow KF, Lee KH. Antitumor agents 287. Substituted 4-amino-2H-pyran-2-one (APO) analogs reveal a new scaffold from neo-tanshinlactone with in vitro anticancer activity. Bioorganic & Medicinal Chemistry Letters. 21: 2341-4. PMID 21420855 DOI: 10.1016/J.Bmcl.2011.02.084 |
0.55 |
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| 2011 |
Chan HH, Hwang TL, Reddy MV, Li DT, Qian K, Bastow KF, Lee KH, Wu TS. Bioactive constituents from the roots of Panax japonicus var. major and development of a LC-MS/MS method for distinguishing between natural and artifactual compounds. Journal of Natural Products. 74: 796-802. PMID 21417387 DOI: 10.1021/Np100851S |
0.551 |
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| 2011 |
Reddy MV, Shen YC, Yang JS, Hwang TL, Bastow KF, Qian K, Lee KH, Wu TS. New bichalcone analogs as NF-κB inhibitors and as cytotoxic agents inducing Fas/CD95-dependent apoptosis. Bioorganic & Medicinal Chemistry. 19: 1895-906. PMID 21377368 DOI: 10.1016/J.Bmc.2011.02.004 |
0.601 |
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| 2011 |
Yang ML, Kuo PC, Hwang TL, Chiou WF, Qian K, Lai CY, Lee KH, Wu TS. Synthesis, in vitro anti-inflammatory and cytotoxic evaluation, and mechanism of action studies of 1-benzoyl-β-carboline and 1-benzoyl-3-carboxy-β-carboline derivatives. Bioorganic & Medicinal Chemistry. 19: 1674-82. PMID 21316977 DOI: 10.1016/J.Bmc.2011.01.034 |
0.595 |
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| 2011 |
Nakagawa-Goto K, Wu PC, Bastow KF, Yang SC, Yu SL, Chen HY, Lin JC, Goto M, Morris-Natschke SL, Yang PC, Lee KH. Antitumor agents 283. Further elaboration of desmosdumotin C analogs as potent antitumor agents: activation of spindle assembly checkpoint as possible mode of action. Bioorganic & Medicinal Chemistry. 19: 1816-22. PMID 21296579 DOI: 10.1016/j.bmc.2011.01.001 |
0.337 |
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| 2011 |
Dong Y, Morris-Natschke SL, Lee KH. Biosynthesis, total syntheses, and antitumor activity of tanshinones and their analogs as potential therapeutic agents. Natural Product Reports. 28: 529-42. PMID 21225077 DOI: 10.1039/C0Np00035C |
0.55 |
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| 2011 |
Dong Y, Nakagawa-Goto K, Lai CY, Kim Y, Morris-Natschke SL, Lee EY, Bastow KF, Lee KH. Antitumor agents 279. Structure-activity relationship and in vivo studies of novel 2-(furan-2-yl)naphthalen-1-ol (FNO) analogs as potent and selective anti-breast cancer agents. Bioorganic & Medicinal Chemistry Letters. 21: 52-7. PMID 21147529 DOI: 10.1016/J.Bmcl.2010.11.077 |
0.568 |
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| 2011 |
Zhang P, Xu L, Qian K, Liu J, Zhang L, Lee KH, Sun H. Efficient synthesis and biological evaluation of epiceanothic acid and related compounds. Bioorganic & Medicinal Chemistry Letters. 21: 338-41. PMID 21123066 DOI: 10.1016/J.Bmcl.2010.11.004 |
0.649 |
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| 2011 |
Shi LS, Chao CH, Shen DY, Chan HH, Chen CH, Liao YR, Wu SJ, Leu YL, Shen YC, Kuo YH, Lee EJ, Qian K, Wu TS, Lee KH. Biologically active constituents from the fruiting body of Taiwanofungus camphoratus. Bioorganic & Medicinal Chemistry. 19: 677-83. PMID 21115251 DOI: 10.1016/J.Bmc.2010.10.032 |
0.598 |
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| 2011 |
Dong Y, Nakagawa-Goto K, Lai CY, Morris-Natschke SL, Bastow KF, Lee KH. Antitumor agents 281. Design, synthesis, and biological activity of substituted 4-amino-7,8,9,10-tetrahydro-2H-benzo[h]chromen-2-one analogs (ATBO) as potent in vitro anticancer agents. Bioorganic & Medicinal Chemistry Letters. 21: 546-9. PMID 21087859 DOI: 10.1016/J.Bmcl.2010.10.074 |
0.592 |
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| 2011 |
Huang Z, Lu Y, Liu Y, Bastow KF, Lee K, Chen D. Kadsufolins A-D and related cytotoxic lignans from Kadsura oblongifolia Helvetica Chimica Acta. 94: 519-527. DOI: 10.1002/Hlca.201000259 |
0.368 |
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| 2010 |
Tian X, Qin B, Wu Z, Wang X, Lu H, Morris-Natschke SL, Chen CH, Jiang S, Lee KH, Xie L. Design, synthesis, and evaluation of diarylpyridines and diarylanilines as potent non-nucleoside HIV-1 reverse transcriptase inhibitors. Journal of Medicinal Chemistry. 53: 8287-97. PMID 21049929 DOI: 10.1021/jm100738d |
0.398 |
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| 2010 |
Wu SJ, Leu YL, Chen CH, Chao CH, Shen DY, Chan HH, Lee EJ, Wu TS, Wang YH, Shen YC, Qian K, Bastow KF, Lee KH. Camphoratins A-J, potent cytotoxic and anti-inflammatory triterpenoids from the fruiting body of Taiwanofungus camphoratus. Journal of Natural Products. 73: 1756-62. PMID 21028898 DOI: 10.1021/Np1002143 |
0.618 |
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| 2010 |
Chou LC, Tsai MT, Hsu MH, Wang SH, Way TD, Huang CH, Lin HY, Qian K, Dong Y, Lee KH, Huang LJ, Kuo SC. Design, synthesis, and preclinical evaluation of new 5,6- (or 6,7-) disubstituted-2-(fluorophenyl)quinolin-4-one derivatives as potent antitumor agents. Journal of Medicinal Chemistry. 53: 8047-58. PMID 20973552 DOI: 10.1021/Jm100780C |
0.665 |
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| 2010 |
Xu SQ, Yan X, Chen Y, Xia P, Qian K, Yu D, Xia Y, Yang ZY, Morris-Natschke SL, Lee KH. Anti-AIDS agents 84. Synthesis and anti-human immunodeficiency virus (HIV) activity of 2'-monomethyl-4-methyl- and 1'-thia-4-methyl-(3'R,4'R)-3',4'-di-O-(S)-camphanoyl-(+)-cis-khellactone (DCK) analogs. Bioorganic & Medicinal Chemistry. 18: 7203-11. PMID 20846868 DOI: 10.1016/J.Bmc.2010.08.031 |
0.703 |
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| 2010 |
Chang CL, Zhang LJ, Chen RY, Kuo LM, Huang JP, Huang HC, Lee KH, Wu YC, Kuo YH. Antioxidant and anti-inflammatory phenylpropanoid derivatives from Calamus quiquesetinervius. Journal of Natural Products. 73: 1482-8. PMID 20825224 DOI: 10.1021/np100181c |
0.302 |
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| 2010 |
Nakagawa-Goto K, Chang PC, Lai CY, Hung HY, Chen TH, Wu PC, Zhu H, Sedykh A, Bastow KF, Lee KH. Antitumor agents. 280. Multidrug resistance-selective desmosdumotin B analogues. Journal of Medicinal Chemistry. 53: 6699-705. PMID 20735140 DOI: 10.1021/Jm100846R |
0.561 |
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| 2010 |
Zhou T, Shi Q, Chen CH, Zhu H, Huang L, Ho P, Lee KH. Anti-AIDS agents 79. Design, synthesis, molecular modeling and structure-activity relationships of novel dicamphanoyl-2',2'-dimethyldihydropyranochromone (DCP) analogs as potent anti-HIV agents. Bioorganic & Medicinal Chemistry. 18: 6678-89. PMID 20728367 DOI: 10.1016/J.Bmc.2010.07.065 |
0.4 |
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| 2010 |
Xiong J, Kashiwada Y, Chen CH, Qian K, Morris-Natschke SL, Lee KH, Takaishi Y. Conjugates of betulin derivatives with AZT as potent anti-HIV agents. Bioorganic & Medicinal Chemistry. 18: 6451-69. PMID 20673723 DOI: 10.1016/J.Bmc.2010.06.092 |
0.622 |
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| 2010 |
Wang Q, Li Y, Song C, Qian K, Chen CH, Lee KH, Chang J. Synthesis and anti-HIV activity of 2'-deoxy-2'-fluoro-4'-C-ethynyl nucleoside analogs. Bioorganic & Medicinal Chemistry Letters. 20: 4053-6. PMID 20542430 DOI: 10.1016/J.Bmcl.2010.05.090 |
0.671 |
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| 2010 |
Dong Y, Nakagawa-Goto K, Lai CY, Morris-Natschke SL, Bastow KF, Lee KH. Antitumor agents 278. 4-Amino-2H-benzo[h]chromen-2-one (ABO) analogs as potent in vitro anti-cancer agents. Bioorganic & Medicinal Chemistry Letters. 20: 4085-7. PMID 20542429 DOI: 10.1016/J.Bmcl.2010.05.079 |
0.573 |
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| 2010 |
Tang J, Qian K, Zhang BN, Chen Y, Xia P, Yu D, Xia Y, Yang ZY, Chen CH, Morris-Natschke SL, Lee KH. Anti-AIDS agents 82: synthesis of seco-(3'R,4'R)-3',4'-di-O-(S)-camphanoyl-(+)-cis-khellactone (DCK) derivatives as novel anti-HIV agents. Bioorganic & Medicinal Chemistry. 18: 4363-73. PMID 20537902 DOI: 10.1016/J.Bmc.2010.04.089 |
0.743 |
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| 2010 |
Qin B, Jiang X, Lu H, Tian X, Barbault F, Huang L, Qian K, Chen CH, Huang R, Jiang S, Lee KH, Xie L. Diarylaniline derivatives as a distinct class of HIV-1 non-nucleoside reverse transcriptase inhibitors. Journal of Medicinal Chemistry. 53: 4906-16. PMID 20527972 DOI: 10.1021/Jm1002952 |
0.568 |
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| 2010 |
Tatsuzaki J, Nakagawa-Goto K, Tokuda H, Lee KH. Cancer preventive agents 10. Prenylated dehydrozingerone analogs as potent chemopreventive agents. Journal of Asian Natural Products Research. 12: 227-32. PMID 20390770 DOI: 10.1080/10286021003591617 |
0.322 |
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| 2010 |
Qian K, Kuo RY, Chen CH, Huang L, Morris-Natschke SL, Lee KH. Anti-AIDS agents 81. Design, synthesis, and structure-activity relationship study of betulinic acid and moronic acid derivatives as potent HIV maturation inhibitors. Journal of Medicinal Chemistry. 53: 3133-41. PMID 20329730 DOI: 10.1021/Jm901782M |
0.608 |
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| 2010 |
Zhang LJ, Chiou CT, Cheng JJ, Huang HC, Kuo LM, Liao CC, Bastow KF, Lee KH, Kuo YH. Cytotoxic polyisoprenyl benzophenonoids from Garcinia subelliptica. Journal of Natural Products. 73: 557-62. PMID 20232858 DOI: 10.1021/np900620y |
0.362 |
|
| 2010 |
Liu J, Zhao M, Qian K, Zhang X, Lee KH, Wu J, Liu YN, Peng S. Benzyl 1,2,3,5,11,11a-hexahydro-3,3-dimethyl-1-oxo-6H-imidazo[3',4':1,2]pyridin[3,4-b]indole-2-substituted acetates: One-pot-preparation, anti-tumor activity, docking toward DNA and 3D QSAR analysis. Bioorganic & Medicinal Chemistry. 18: 1910-7. PMID 20171109 DOI: 10.1016/J.Bmc.2010.01.038 |
0.526 |
|
| 2010 |
Dong Y, Shi Q, Pai HC, Peng CY, Pan SL, Teng CM, Nakagawa-Goto K, Yu D, Liu YN, Wu PC, Bastow KF, Morris-Natschke SL, Brossi A, Lang JY, Hsu JL, ... ... Lee KH, et al. Antitumor agents. 272. Structure-activity relationships and in vivo selective anti-breast cancer activity of novel neo-tanshinlactone analogues. Journal of Medicinal Chemistry. 53: 2299-308. PMID 20148565 DOI: 10.1021/Jm1000858 |
0.71 |
|
| 2010 |
Chou LC, Chen CT, Lee JC, Way TD, Huang CH, Huang SM, Teng CM, Yamori T, Wu TS, Sun CM, Chien DS, Qian K, Morris-Natschke SL, Lee KH, Huang LJ, et al. Synthesis and preclinical evaluations of 2-(2-fluorophenyl)-6,7-methylenedioxyquinolin-4-one monosodium phosphate (CHM-1-P-Na) as a potent antitumor agent. Journal of Medicinal Chemistry. 53: 1616-26. PMID 20102207 DOI: 10.1021/Jm901292J |
0.585 |
|
| 2010 |
Yen CT, Nakagawa-Goto K, Hwang TL, Wu PC, Morris-Natschke SL, Lai WC, Bastow KF, Chang FR, Wu YC, Lee KH. Antitumor agents. 271: total synthesis and evaluation of brazilein and analogs as anti-inflammatory and cytotoxic agents. Bioorganic & Medicinal Chemistry Letters. 20: 1037-9. PMID 20036537 DOI: 10.1016/j.bmcl.2009.12.041 |
0.369 |
|
| 2010 |
Dong Y, Shi Q, Nakagawa-Goto K, Wu PC, Morris-Natschke SL, Brossi A, Bastow KF, Lang JY, Hung MC, Lee KH. Antitumor agents 270. Novel substituted 6-phenyl-4H-furo[3,2-c]pyran-4-one derivatives as potent and highly selective anti-breast cancer agents. Bioorganic & Medicinal Chemistry. 18: 803-8. PMID 20034799 DOI: 10.1016/J.Bmc.2009.11.049 |
0.546 |
|
| 2010 |
Li SL, Song JZ, Qiao CF, Zhou Y, Qian K, Lee KH, Xu HX. A novel strategy to rapidly explore potential chemical markers for the discrimination between raw and processed Radix Rehmanniae by UHPLC-TOFMS with multivariate statistical analysis. Journal of Pharmaceutical and Biomedical Analysis. 51: 812-23. PMID 19879709 DOI: 10.1016/j.jpba.2009.10.002 |
0.459 |
|
| 2009 |
Dong Y, Shi Q, Nakagawa-Goto K, Wu PC, Bastow KF, Morris-Natschke SL, Lee KH. Antitumor agents 269. Non-aromatic ring-A neotanshinlactone analog, TNO, as a new class of potent antitumor agents. Bioorganic & Medicinal Chemistry Letters. 19: 6289-92. PMID 19819136 DOI: 10.1016/J.Bmcl.2009.09.092 |
0.599 |
|
| 2009 |
Kuo RY, Qian K, Morris-Natschke SL, Lee KH. Plant-derived triterpenoids and analogues as antitumor and anti-HIV agents. Natural Product Reports. 26: 1321-44. PMID 19779642 DOI: 10.1039/B810774M |
0.642 |
|
| 2009 |
Chang YH, Hsu MH, Wang SH, Huang LJ, Qian K, Morris-Natschke SL, Hamel E, Kuo SC, Lee KH. Design and synthesis of 2-(3-benzo[b]thienyl)-6,7-methylenedioxyquinolin-4-one analogues as potent antitumor agents that inhibit tubulin assembly. Journal of Medicinal Chemistry. 52: 4883-91. PMID 19719238 DOI: 10.1021/Jm900456W |
0.626 |
|
| 2009 |
Tian X, Qin B, Lu H, Lai W, Jiang S, Lee KH, Chen CH, Xie L. Discovery of diarylpyridine derivatives as novel non-nucleoside HIV-1 reverse transcriptase inhibitors. Bioorganic & Medicinal Chemistry Letters. 19: 5482-5. PMID 19666220 DOI: 10.1016/j.bmcl.2009.07.080 |
0.35 |
|
| 2009 |
Yang X, Shi Q, Liu YN, Zhao G, Bastow KF, Lin JC, Yang SC, Yang PC, Lee KH. Antitumor agents 268. Design, synthesis, and mechanistic studies of new 9-substituted phenanthrene-based tylophorine analogues as potent cytotoxic agents. Journal of Medicinal Chemistry. 52: 5262-8. PMID 19645447 DOI: 10.1021/Jm9009263 |
0.389 |
|
| 2009 |
Su CR, Yeh SF, Liu CM, Damu AG, Kuo TH, Chiang PC, Bastow KF, Lee KH, Wu TS. Anti-HBV and cytotoxic activities of pyranocoumarin derivatives. Bioorganic & Medicinal Chemistry. 17: 6137-43. PMID 19635670 DOI: 10.1016/j.bmc.2008.12.007 |
0.325 |
|
| 2009 |
Huang F, Zhao M, Zhang X, Wang C, Qian K, Kuo RY, Morris-Natschke S, Lee KH, Peng S. Synthesis, DNA intercalation and 3D QSAR analysis of cis-2,4,5-trisubstituted-1,3-dithiolanes as a novel class of antitumor agents. Bioorganic & Medicinal Chemistry. 17: 6085-95. PMID 19631550 DOI: 10.1016/J.Bmc.2009.06.011 |
0.547 |
|
| 2009 |
Wu J, Zhao M, Qian K, Lee KH, Morris-Natschke S, Peng S. Novel N-(3-carboxyl-9-benzyl-beta-carboline-1-yl)ethylamino acids: synthesis, anti-tumor evaluation, intercalating determination, 3D QSAR analysis and docking investigation. European Journal of Medicinal Chemistry. 44: 4153-61. PMID 19535177 DOI: 10.1016/J.Ejmech.2009.05.006 |
0.613 |
|
| 2009 |
Dang Z, Lai W, Qian K, Ho P, Lee KH, Chen CH, Huang L. Betulinic acid derivatives as human immunodeficiency virus type 2 (HIV-2) inhibitors. Journal of Medicinal Chemistry. 52: 7887-91. PMID 19526990 DOI: 10.1021/Jm9004253 |
0.575 |
|
| 2009 |
Nakagawa-Goto K, Yamada K, Taniguchi M, Tokuda H, Lee KH. Cancer preventive agents 9. Betulinic acid derivatives as potent cancer chemopreventive agents. Bioorganic & Medicinal Chemistry Letters. 19: 3378-81. PMID 19481937 DOI: 10.1016/j.bmcl.2009.05.050 |
0.387 |
|
| 2009 |
Dong Y, Shi Q, Liu YN, Wang X, Bastow KF, Lee KH. Antitumor agents. 266. Design, synthesis, and biological evaluation of novel 2-(furan-2-yl)naphthalen-1-ol derivatives as potent and selective antibreast cancer agents. Journal of Medicinal Chemistry. 52: 3586-90. PMID 19425534 DOI: 10.1021/Jm9001567 |
0.578 |
|
| 2009 |
Qian K, Yu D, Chen CH, Huang L, Morris-Natschke SL, Nitz TJ, Salzwedel K, Reddick M, Allaway GP, Lee KH. Anti-AIDS agents. 78. Design, synthesis, metabolic stability assessment, and antiviral evaluation of novel betulinic acid derivatives as potent anti-human immunodeficiency virus (HIV) agents. Journal of Medicinal Chemistry. 52: 3248-58. PMID 19388685 DOI: 10.1021/Jm900136J |
0.725 |
|
| 2009 |
Lin JC, Yang SC, Hong TM, Yu SL, Shi Q, Wei L, Chen HY, Yang PC, Lee KH. Phenanthrene-based tylophorine-1 (PBT-1) inhibits lung cancer cell growth through the Akt and NF-kappaB pathways. Journal of Medicinal Chemistry. 52: 1903-11. PMID 19284764 DOI: 10.1021/Jm801344J |
0.586 |
|
| 2009 |
Lee CL, Chang FR, Yen MH, Yu D, Liu YN, Bastow KF, Morris-Natschke SL, Wu YC, Lee KH. Cytotoxic phenanthrenequinones and 9,10-dihydrophenanthrenes from Calanthe arisanensis. Journal of Natural Products. 72: 210-3. PMID 19193043 DOI: 10.1021/Np800622A |
0.604 |
|
| 2009 |
Lee KH, Yu DH, Lee YS. Gene expression profiling of rat cerebral cortex development using cDNA microarrays. Neurochemical Research. 34: 1030-8. PMID 18987971 DOI: 10.1007/s11064-008-9867-6 |
0.44 |
|
| 2009 |
Qian K, Morris-Natschke SL, Lee KH. HIV entry inhibitors and their potential in HIV therapy. Medicinal Research Reviews. 29: 369-93. PMID 18720513 DOI: 10.1002/Med.20138 |
0.546 |
|
| 2009 |
Usami Y, Arimoto M, Kobayashi K, Honjou M, Yamanaka M, Miyao M, Ichikawa H, F. Bastow K, Lee K. Synthesis of Aryltetralin Type 2-Azalignans Using Schöllkopf ’s Bislactim-Ether Methodology Heterocycles. 78: 2041. DOI: 10.3987/Com-09-11716 |
0.367 |
|
| 2009 |
Iwasa K, Okada S, Nishiyama Y, Takeuchi S, Moriyasu M, Tode C, Sugiura M, Takeuchi A, Tokuda H, Takeda K, Liu YN, Wu PC, Bastow KF, Akiyama T, Lee KH. Geranyl derivatives of salsolinol show increased biological activities Heterocycles. 77: 1355-1369. DOI: 10.3987/Com-08-S(F)64 |
0.393 |
|
| 2008 |
Takasaki M, Konoshima T, Kozuka M, Tokuda H, Takayasu J, Nishino H, Miyakoshi M, Mizutani K, Lee KH. Cancer preventive agents. Part 8: Chemopreventive effects of stevioside and related compounds. Bioorganic & Medicinal Chemistry. 17: 600-5. PMID 19131254 DOI: 10.1016/j.bmc.2008.11.077 |
0.35 |
|
| 2008 |
Xie L, Guo HF, Lu H, Zhuang XM, Zhang AM, Wu G, Ruan JX, Zhou T, Yu D, Qian K, Lee KH, Jiang S. Development and preclinical studies of broad-spectrum anti-HIV agent (3'R,4'R)-3-cyanomethyl-4-methyl-3',4'-di-O-(S)-camphanoyl-(+)-cis-khellactone (3-cyanomethyl-4-methyl-DCK). Journal of Medicinal Chemistry. 51: 7689-96. PMID 19053755 DOI: 10.1021/Jm8003009 |
0.706 |
|
| 2008 |
Wu G, Guo HF, Gao K, Liu YN, Bastow KF, Morris-Natschke SL, Lee KH, Xie L. Synthesis of unsymmetrical biphenyls as potent cytotoxic agents. Bioorganic & Medicinal Chemistry Letters. 18: 5272-6. PMID 18782668 DOI: 10.1016/j.bmcl.2008.08.050 |
0.387 |
|
| 2008 |
Lee CL, Nakagawa-Goto K, Yu D, Liu YN, Bastow KF, Morris-Natschke SL, Chang FR, Wu YC, Lee KH. Cytotoxic calanquinone A from Calanthe arisanensis and its first total synthesis. Bioorganic & Medicinal Chemistry Letters. 18: 4275-7. PMID 18640035 DOI: 10.1016/j.bmcl.2008.06.099 |
0.572 |
|
| 2008 |
Reddy MV, Su CR, Chiou WF, Liu YN, Chen RY, Bastow KF, Lee KH, Wu TS. Design, synthesis, and biological evaluation of Mannich bases of heterocyclic chalcone analogs as cytotoxic agents. Bioorganic & Medicinal Chemistry. 16: 7358-70. PMID 18602831 DOI: 10.1016/j.bmc.2008.06.018 |
0.38 |
|
| 2008 |
Huang L, Yu D, Ho P, Qian K, Lee KH, Chen CH. Synthesis and proteasome inhibition of glycyrrhetinic acid derivatives. Bioorganic & Medicinal Chemistry. 16: 6696-701. PMID 18562200 DOI: 10.1016/J.Bmc.2008.05.078 |
0.654 |
|
| 2008 |
Chen Y, Cui G, Zhao M, Wang C, Qian K, Morris-Natschke S, Lee KH, Peng S. Synthesis, nano-scale assembly, and in vivo anti-thrombotic activity of novel short peptides containing L-Arg and L-Asp or L-Glu. Bioorganic & Medicinal Chemistry. 16: 5914-25. PMID 18495483 DOI: 10.1016/J.Bmc.2008.04.064 |
0.443 |
|
| 2008 |
Nakagawa-Goto K, Bastow KF, Chen TH, Morris-Natschke SL, Lee KH. Antitumor agents 260. New desmosdumotin B analogues with improved in vitro anticancer activity. Journal of Medicinal Chemistry. 51: 3297-303. PMID 18473435 DOI: 10.1021/jm701208v |
0.364 |
|
| 2008 |
Su CR, Damu AG, Chiang PC, Bastow KF, Morris-Natschke SL, Lee KH, Wu TS. Total synthesis of phenanthroindolizidine alkaloids (+/-)-antofine, (+/-)-deoxypergularinine, and their dehydro congeners and evaluation of their cytotoxic activity. Bioorganic & Medicinal Chemistry. 16: 6233-41. PMID 18456501 DOI: 10.1016/j.bmc.2008.04.032 |
0.324 |
|
| 2008 |
Lin AS, Qian K, Usami Y, Lin L, Itokawa H, Hsu C, Morris-Natschke SL, Lee KH. 5-Hydroxymethyl-2-furfural, a clinical trials agent for sickle cell anemia, and its mono/di-glucosides from classically processed steamed Rehmanniae Radix. Journal of Natural Medicines. 62: 164-7. PMID 18404317 DOI: 10.1007/S11418-007-0206-Z |
0.494 |
|
| 2008 |
Kuo PC, Shen YC, Yang ML, Wang SH, Thang TD, Dung NX, Chiang PC, Lee KH, Lee EJ, Wu TS. Crotonkinins A and B and related diterpenoids from Croton tonkinensis as anti-inflammatory and antitumor agents. Journal of Natural Products. 70: 1906-9. PMID 18161942 DOI: 10.1021/Np070383F |
0.481 |
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| 2008 |
Gao W, Chen AP, Leung CH, Gullen EA, Fürstner A, Shi Q, Wei L, Lee KH, Cheng YC. Structural analogs of tylophora alkaloids may not be functional analogs. Bioorganic & Medicinal Chemistry Letters. 18: 704-9. PMID 18077159 DOI: 10.1016/J.Bmcl.2007.11.054 |
0.599 |
|
| 2007 |
Cheon SH, Lee KH, Kwon JY, Ryu HN, Yu DH, Choi YS, Kim DI. Effects of silkworm hemolymph on cell viability and hCTLA4Ig production in transgenic rice cell suspension cultures. Journal of Microbiology and Biotechnology. 17: 1944-8. PMID 18167440 |
0.448 |
|
| 2007 |
Qian K, Nakagawa-Goto K, Yu D, Morris-Natschke SL, Nitz TJ, Kilgore N, Allaway GP, Lee KH. Anti-AIDS agents 73: structure-activity relationship study and asymmetric synthesis of 3-O-monomethylsuccinyl-betulinic acid derivatives. Bioorganic & Medicinal Chemistry Letters. 17: 6553-7. PMID 17935987 DOI: 10.1016/J.Bmcl.2007.09.081 |
0.693 |
|
| 2007 |
Suzuki M, Yu D, Morris-Natschke SL, Smith PC, Lee KH. Anti-AIDS agents 66: syntheses and anti-HIV activity of phenolic and aza 3',4'-di-O-(-)-camphanoyl-(+)-cis-khellactone (DCK) derivatives. Bioorganic & Medicinal Chemistry. 15: 6852-8. PMID 17719228 DOI: 10.1016/J.Bmc.2006.12.013 |
0.724 |
|
| 2007 |
Wang Q, Mu Q, Shibano M, Morris-Natschke SL, Lee KH, Chen DF. Eremophilane sesquiterpenes from Ligularia macrophylla. Journal of Natural Products. 70: 1259-62. PMID 17672504 DOI: 10.1021/Np070113X |
0.314 |
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| 2007 |
Nakagawa-Goto K, Yamada K, Nakamura S, Chen TH, Chiang PC, Bastow KF, Wang SC, Spohn B, Hung MC, Lee FY, Lee FC, Lee KH. Antitumor agents. 258. Syntheses and evaluation of dietary antioxidant--taxoid conjugates as novel cytotoxic agents. Bioorganic & Medicinal Chemistry Letters. 17: 5204-9. PMID 17643301 DOI: 10.1016/j.bmcl.2007.06.083 |
0.345 |
|
| 2007 |
Zhou LB, Chen TH, Bastow KF, Shibano M, Lee KH, Chen DF. Filiasparosides A-D, cytotoxic steroidal saponins from the roots of Asparagus filicinus. Journal of Natural Products. 70: 1263-7. PMID 17629328 DOI: 10.1021/Np070138W |
0.446 |
|
| 2007 |
Lin AS, Nakagawa-Goto K, Chang FR, Yu D, Morris-Natschke SL, Wu CC, Chen SL, Wu YC, Lee KH. First total synthesis of protoapigenone and its analogues as potent cytotoxic agents. Journal of Medicinal Chemistry. 50: 3921-7. PMID 17622129 DOI: 10.1021/Jm070363A |
0.619 |
|
| 2007 |
Wei L, Shi Q, Bastow KF, Brossi A, Morris-Natschke SL, Nakagawa-Goto K, Wu TS, Pan SL, Teng CM, Lee KH. Antitumor agents 253. Design, synthesis, and antitumor evaluation of novel 9-substituted phenanthrene-based tylophorine derivatives as potential anticancer agents. Journal of Medicinal Chemistry. 50: 3674-80. PMID 17585747 DOI: 10.1021/Jm061366A |
0.619 |
|
| 2007 |
Damu AG, Kuo PC, Su CR, Kuo TH, Chen TH, Bastow KF, Lee KH, Wu TS. Isolation, structures, and structure - cytotoxic activity relationships of withanolides and physalins from Physalis angulata. Journal of Natural Products. 70: 1146-52. PMID 17580910 DOI: 10.1021/np0701374 |
0.332 |
|
| 2007 |
Nakagawa-Goto K, Chen TH, Peng CY, Bastow KF, Wu JH, Lee KH. Antitumor agents 259. Design, syntheses, and structure-activity relationship study of desmosdumotin C analogs. Journal of Medicinal Chemistry. 50: 3354-8. PMID 17569518 DOI: 10.1021/jm0702534 |
0.357 |
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| 2007 |
Wang Y, Huang SX, Xia P, Xia Y, Yang ZY, Kilgore N, Morris-Natschke SL, Lee KH. Anti-AIDS agents 72. Bioisosteres (7-carbon-DCKs) of the potent anti-HIV lead DCK. Bioorganic & Medicinal Chemistry Letters. 17: 4316-9. PMID 17533128 DOI: 10.1016/j.bmcl.2007.05.026 |
0.32 |
|
| 2007 |
Rosselli S, Bruno M, Maggio A, Bellone G, Chen TH, Bastow KF, Lee KH. Cytotoxic activity of some natural and synthetic ent-kauranes. Journal of Natural Products. 70: 347-52. PMID 17378530 DOI: 10.1021/Np060504W |
0.472 |
|
| 2007 |
Nakagawa-Goto K, Nakamura S, Bastow KF, Nyarko A, Peng CY, Lee FY, Lee FC, Lee KH. Antitumor agents. 256. Conjugation of paclitaxel with other antitumor agents: evaluation of novel conjugates as cytotoxic agents. Bioorganic & Medicinal Chemistry Letters. 17: 2894-8. PMID 17350834 DOI: 10.1016/j.bmcl.2007.02.051 |
0.313 |
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| 2007 |
Zhang S, Wei L, Bastow K, Zheng W, Brossi A, Lee KH, Tropsha A. Antitumor agents 252. Application of validated QSAR models to database mining: discovery of novel tylophorine derivatives as potential anticancer agents. Journal of Computer-Aided Molecular Design. 21: 97-112. PMID 17340042 DOI: 10.1007/S10822-007-9102-6 |
0.535 |
|
| 2007 |
Wang X, Morris-Natschke SL, Lee KH. New developments in the chemistry and biology of the bioactive constituents of Tanshen. Medicinal Research Reviews. 27: 133-48. PMID 16888751 DOI: 10.1002/med.20077 |
0.312 |
|
| 2007 |
Yu D, Morris-Natschke SL, Lee KH. New developments in natural products-based anti-AIDS research. Medicinal Research Reviews. 27: 108-32. PMID 16888749 DOI: 10.1002/med.20075 |
0.607 |
|
| 2006 |
Wang AG, Lee KY, Kim SY, Choi JY, Lee KH, Kim WH, Wang HJ, Kim JM, Park MG, Yeom YI, Kim NS, Yu DY, Lee DS. The expression of estrogen receptors in hepatocellular carcinoma in Korean patients. Yonsei Medical Journal. 47: 811-6. PMID 17191310 DOI: 10.3349/ymj.2006.47.6.811 |
0.421 |
|
| 2006 |
Chen M, Kilgore N, Lee KH, Chen DF. Rubrisandrins A and B, lignans and related anti-HIV compounds from Schisandra rubriflora. Journal of Natural Products. 69: 1697-701. PMID 17190445 DOI: 10.1021/np060239e |
0.337 |
|
| 2006 |
Wu PL, Hsu YL, Wu TS, Bastow KF, Lee KH. Kalanchosides A-C, new cytotoxic bufadienolides from the aerial parts of Kalanchoe gracilis. Organic Letters. 8: 5207-10. PMID 17078679 DOI: 10.1021/Ol061873M |
0.498 |
|
| 2006 |
Tatsuzaki J, Bastow KF, Nakagawa-Goto K, Nakamura S, Itokawa H, Lee KH. Dehydrozingerone, chalcone, and isoeugenol analogues as in vitro anticancer agents. Journal of Natural Products. 69: 1445-9. PMID 17067159 DOI: 10.1021/np060252z |
0.35 |
|
| 2006 |
Wang AG, Fang W, Han YH, Cho SM, Choi JY, Lee KH, Kim WH, Kim JM, Park MG, Yu DY, Kim NS, Lee DS. Expression of the RERG gene is gender-dependent in hepatocellular carcinoma and regulated by histone deacetyltransferases. Journal of Korean Medical Science. 21: 891-6. PMID 17043425 DOI: 10.3346/jkms.2006.21.5.891 |
0.462 |
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| 2006 |
Kim MH, Cho D, Kim HJ, Chong SJ, Lee KH, Yu DS, Park CJ, Lee JY, Cho BK, Park HJ. Investigation of the corticotropin-releasing hormone-proopiomelanocortin axis in various skin tumours. The British Journal of Dermatology. 155: 910-5. PMID 17034518 DOI: 10.1111/j.1365-2133.2006.07442.x |
0.402 |
|
| 2006 |
Horiuch M, Murakami C, Fukamiya N, Yu D, Chen TH, Bastow KF, Zhang DC, Takaishi Y, Imakura Y, Lee KH. Tripfordines A-C, sesquiterpene pyridine alkaloids from Tripterygium wilfordii, and structure anti-HIV activity relationships of Tripterygium alkaloids. Journal of Natural Products. 69: 1271-4. PMID 16989518 DOI: 10.1021/Np060124A |
0.627 |
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| 2006 |
Wang X, Nakagawa-Goto K, Bastow KF, Don MJ, Lin YL, Wu TS, Lee KH. Antitumor agents. 254. Synthesis and biological evaluation of novel neo-tanshinlactone analogues as potent anti-breast cancer agents. Journal of Medicinal Chemistry. 49: 5631-4. PMID 16942038 DOI: 10.1021/Jm060184D |
0.367 |
|
| 2006 |
Yu D, Sakurai Y, Chen CH, Chang FR, Huang L, Kashiwada Y, Lee KH. Anti-AIDS agents 69. Moronic acid and other triterpene derivatives as novel potent anti-HIV agents. Journal of Medicinal Chemistry. 49: 5462-9. PMID 16942019 DOI: 10.1021/Jm0601912 |
0.646 |
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| 2006 |
Wei L, Brossi A, Kendall R, Bastow KF, Morris-Natschke SL, Shi Q, Lee KH. Antitumor agents 251: synthesis, cytotoxic evaluation, and structure-activity relationship studies of phenanthrene-based tylophorine derivatives (PBTs) as a new class of antitumor agents. Bioorganic & Medicinal Chemistry. 14: 6560-9. PMID 16809043 DOI: 10.1016/J.Bmc.2006.06.009 |
0.629 |
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| 2006 |
Sakurai Y, Sakurai N, Taniguchi M, Nakanishi Y, Bastow KF, Wang X, Cragg GM, Lee KH. Rautandiols A and B, pterocarpans and cytotoxic constituents from Neorautanenia mitis. Journal of Natural Products. 69: 397-9. PMID 16562843 DOI: 10.1021/Np058070C |
0.326 |
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| 2006 |
Sakurai N, Nakagawa-Goto K, Ito J, Sakurai Y, Nakanishi Y, Bastow KF, Cragg G, Lee KH. Cytotoxic Alangium alkaloids from Alangium longiflorum. Phytochemistry. 67: 894-7. PMID 16530796 DOI: 10.1016/j.phytochem.2006.01.009 |
0.334 |
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| 2006 |
Lin L, Shi Q, Su CY, Shih CC, Lee KH. Antitumor agents 247. New 4-ethoxycarbonylethyl curcumin analogs as potential antiandrogenic agents. Bioorganic & Medicinal Chemistry. 14: 2527-34. PMID 16427289 DOI: 10.1016/j.bmc.2005.11.034 |
0.325 |
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| 2006 |
Suzuki M, Nakagawa-Goto K, Nakamura S, Tokuda H, Morris-Natschke SL, Kozuka M, Nishino H, Lee K. Cancer Preventive Agents. Part 5. Anti-tumor-Promoting Effects of Coumarins and Related Compounds on Epstein-Barr Virus Activation and Two-stage Mouse Skin Carcinogenesis Pharmaceutical Biology. 44: 178-182. DOI: 10.1080/13880200600686491 |
0.626 |
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| 2006 |
Wang X, Nakagawa-Goto K, Kozuka M, Tokuda H, Nishino H, Lee K. Cancer preventive agents. Part 6: Chemopreventive potential of furanocoumarins and related compounds Pharmaceutical Biology. 44: 116-120. DOI: 10.1080/13880200600592178 |
0.428 |
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| 2006 |
Nakagawa-Goto K, Lee K. Anti-AIDS agents 68. The first total synthesis of a unique potent anti-HIV chalcone from genus Desmos Tetrahedron Letters. 47: 8263-8266. DOI: 10.1016/J.Tetlet.2006.09.110 |
0.416 |
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| 2005 |
Ahn MJ, Yoo YD, Lee KH, Ahn JI, Yu DH, Lee HS, Oh HS, Choi JH, Lee YS. cDNA microarray analysis of differential gene expression in gastric cancer cells sensitive and resistant to 5-fluorouracil and cisplatin. Cancer Research and Treatment : Official Journal of Korean Cancer Association. 37: 54-62. PMID 19956511 DOI: 10.4143/crt.2005.37.1.54 |
0.458 |
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| 2005 |
Bruno M, Rosselli S, Maggio A, Raccuglia RA, Bastow KF, Wu CC, Lee KH. Cytotoxic activity of some natural and synthetic sesquiterpene lactones. Planta Medica. 71: 1176-8. PMID 16395659 DOI: 10.1055/s-2005-873139 |
0.303 |
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| 2005 |
Huang L, Ho P, Lee KH, Chen CH. Synthesis and anti-HIV activity of bi-functional betulinic acid derivatives. Bioorganic & Medicinal Chemistry. 14: 2279-89. PMID 16314103 DOI: 10.1016/j.bmc.2005.11.016 |
0.375 |
|
| 2005 |
Nedashkovskaya OI, Kim SB, Suzuki M, Shevchenko LS, Lee MS, Lee KH, Park MS, Frolova GM, Oh HW, Bae KS, Park HY, Mikhailov VV. Pontibacter actiniarum gen. nov., sp. nov., a novel member of the phylum 'Bacteroidetes', and proposal of Reichenbachiella gen. nov. as a replacement for the illegitimate prokaryotic generic name Reichenbachia Nedashkovskaya et al. 2003. International Journal of Systematic and Evolutionary Microbiology. 55: 2583-8. PMID 16280531 DOI: 10.1099/ijs.0.63819-0 |
0.425 |
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| 2005 |
Cheng MJ, Lee KH, Tsai IL, Chen IS. Two new sesquiterpenoids and anti-HIV principles from the root bark of Zanthoxylum ailanthoides. Bioorganic & Medicinal Chemistry. 13: 5915-20. PMID 16140017 DOI: 10.1016/j.bmc.2005.07.050 |
0.37 |
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| 2005 |
Suzuki M, Li Y, Smith PC, Swenberg JA, Martin DE, Morris-Natschke SL, Lee KH. Anti-AIDS agents 65: investigation of the in vitro oxidative metabolism of 3',4'-Di-O-(-)-camphanoyl-(+)-cis-khellactone derivatives as potent anti-hiv agents. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 33: 1588-92. PMID 16087699 DOI: 10.1124/Dmd.105.004218 |
0.555 |
|
| 2005 |
Xie L, Zhao CH, Zhou T, Chen HF, Fan BT, Chen XH, Ma JZ, Li JY, Bao ZY, Lo Z, Yu D, Lee KH. Molecular modeling, design, synthesis, and biological evaluation of novel 3',4'-dicamphanoyl-(+)-cis-khellactone (DCK) analogs as potent anti-HIV agents. Bioorganic & Medicinal Chemistry. 13: 6435-49. PMID 16061386 DOI: 10.1016/J.Bmc.2005.06.057 |
0.62 |
|
| 2005 |
Bruno M, Rosselli S, Maggio A, Raccuglia RA, Bastow KF, Lee KH. Cytotoxic activity of some natural and synthetic guaianolides. Journal of Natural Products. 68: 1042-6. PMID 16038545 DOI: 10.1021/np0500575 |
0.347 |
|
| 2005 |
Yu D, Wild CT, Martin DE, Morris-Natschke SL, Chen CH, Allaway GP, Lee KH. The discovery of a class of novel HIV-1 maturation inhibitors and their potential in the therapy of HIV. Expert Opinion On Investigational Drugs. 14: 681-93. PMID 16004596 DOI: 10.1517/13543784.14.6.681 |
0.602 |
|
| 2005 |
Nakamura S, Kozuka M, Bastow KF, Tokuda H, Nishino H, Suzuki M, Tatsuzaki J, Morris Natschke SL, Kuo SC, Lee KH. Cancer preventive agents, Part 2: Synthesis and evaluation of 2-phenyl-4-quinolone and 9-oxo-9,10-dihydroacridine derivatives as novel antitumor promoters. Bioorganic & Medicinal Chemistry. 13: 4396-401. PMID 15914009 DOI: 10.1016/J.Bmc.2005.04.078 |
0.596 |
|
| 2005 |
Nakagawa-Goto K, Bastow KF, Wu JH, Tokuda H, Lee KH. Total synthesis and bioactivity of unique flavone desmosdumotin B and its analogs. Bioorganic & Medicinal Chemistry Letters. 15: 3016-9. PMID 15913998 DOI: 10.1016/j.bmcl.2005.04.070 |
0.359 |
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| 2005 |
Fukamiya N, Lee KH, Muhammad I, Murakami C, Okano M, Harvey I, Pelletier J. Structure-activity relationships of quassinoids for eukaryotic protein synthesis. Cancer Letters. 220: 37-48. PMID 15737686 DOI: 10.1016/J.Canlet.2004.04.023 |
0.305 |
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| 2005 |
Nakagawa-Goto K, Wu JH, Bastow KF, Wu CC, Lee KH. Antitumor agents 243. Syntheses and cytotoxicity of desmosdumotin C derivatives. Bioorganic & Medicinal Chemistry. 13: 2325-30. PMID 15727881 DOI: 10.1016/j.bmc.2004.12.040 |
0.329 |
|
| 2005 |
Huang L, Yuan X, Yu D, Lee KH, Chen CH. Mechanism of action and resistant profile of anti-HIV-1 coumarin derivatives. Virology. 332: 623-8. PMID 15680427 DOI: 10.1016/J.Virol.2004.11.033 |
0.55 |
|
| 2005 |
Sakurai N, Kozuka M, Tokuda H, Mukainaka T, Enjo F, Nishino H, Nagai M, Sakurai Y, Lee KH. Cancer preventive agents. Part 1: chemopreventive potential of cimigenol, cimigenol-3,15-dione, and related compounds. Bioorganic & Medicinal Chemistry. 13: 1403-8. PMID 15670948 DOI: 10.1016/j.bmc.2004.10.062 |
0.33 |
|
| 2005 |
Wu PL, Wu TS, He CX, Su CH, Lee KH. Constituents from the stems of Hibiscus taiwanensis. Chemical & Pharmaceutical Bulletin. 53: 56-9. PMID 15635230 DOI: 10.1248/CPB.53.56 |
0.331 |
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| 2005 |
Kashiwada Y, Aoshima A, Ikeshiro Y, Chen YP, Furukawa H, Itoigawa M, Fujioka T, Mihashi K, Cosentino LM, Morris-Natschke SL, Lee KH. Anti-HIV benzylisoquinoline alkaloids and flavonoids from the leaves of Nelumbo nucifera, and structure-activity correlations with related alkaloids. Bioorganic & Medicinal Chemistry. 13: 443-8. PMID 15598565 DOI: 10.1016/j.bmc.2004.10.020 |
0.403 |
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| 2005 |
Lai YY, Huang LJ, Lee KH, Xiao Z, Bastow KF, Yamori T, Kuo SC. Synthesis and biological relationships of 3',6-substituted 2-phenyl-4-quinolone-3-carboxylic acid derivatives as antimitotic agents. Bioorganic & Medicinal Chemistry. 13: 265-75. PMID 15582470 DOI: 10.1016/j.bmc.2004.09.041 |
0.565 |
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| 2005 |
Kawaguchi Y, Ochi T, Takaishi Y, Kawazoe K, Lee KH. New sesquiterpenes from Capsicum annuum. Journal of Natural Products. 67: 1893-6. PMID 15568784 DOI: 10.1021/np0305472 |
0.307 |
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| 2005 |
Chen Y, Zhang Q, Zhang B, Xia P, Xia Y, Yang ZY, Kilgore N, Wild C, Morris-Natschke SL, Lee KH. Anti-AIDS agents. Part 56: Synthesis and anti-HIV activity of 7-thia-di-O-(-)-camphanoyl-(+)-cis-khellactone (7-thia-DCK) analogs. Bioorganic & Medicinal Chemistry. 12: 6383-7. PMID 15556756 DOI: 10.1016/J.Bmc.2004.09.038 |
0.484 |
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| 2005 |
Xia P, Yin ZJ, Chen Y, Zhang Q, Zhang B, Xia Y, Yang ZY, Kilgore N, Wild C, Morris-Natschke SL, Lee KH. Anti-AIDS agents. Part 58: synthesis and anti-HIV activity of 1-thia-di-O-(-)-camphanoyl-(+)-cis-khellactone (1-thia-DCK) analogues. Bioorganic & Medicinal Chemistry Letters. 14: 3341-3. PMID 15149703 DOI: 10.1016/j.bmcl.2004.03.051 |
0.383 |
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| 2005 |
Nakagawa-Goto K, Jung MK, Hamel E, Wu CC, Bastow KF, Brossi A, Ohta S, Lee KH. Antitumor agents 238. Anti-tubulin and in vitrocytotoxic effects of N-substituted allocolchicinoids Heterocycles. 65: 541-550. DOI: 10.3987/Com-04-10244 |
0.448 |
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| 2004 |
Ahn MJ, Lee KH, Ahn JI, Yu DH, Lee HS, Choi JH, Jang JS, Bae JM, Lee YS. The differential gene expression profiles between sensitive and resistant breast cancer cells to adriamycin by cDNA microarray. Cancer Research and Treatment : Official Journal of Korean Cancer Association. 36: 43-9. PMID 20396564 DOI: 10.4143/crt.2004.36.1.43 |
0.471 |
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| 2004 |
Tanaka N, Takaishi Y, Shikishima Y, Nakanishi Y, Bastow K, Lee KH, Honda G, Ito M, Takeda Y, Kodzhimatov OK, Ashurmetov O. Prenylated benzophenones and xanthones from Hypericum scabrum. Journal of Natural Products. 67: 1870-5. PMID 15568778 DOI: 10.1021/Np040024+ |
0.396 |
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| 2004 |
Zhang Q, Chen Y, Xia P, Xia Y, Yang ZY, Yu D, Morris-Natschke SL, Lee KH. Anti-AIDS agents. Part 62: anti-HIV activity of 2'-substituted 4-methyl-3',4'-di-O-(-)-camphanoyl-(+)-cis-khellactone (4-methyl DCK) analogs. Bioorganic & Medicinal Chemistry Letters. 14: 5855-7. PMID 15501055 DOI: 10.1016/J.Bmcl.2004.09.032 |
0.584 |
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| 2004 |
Xiao Z, Bastow KF, Vance JR, Sidwell RS, Wang HK, Chen MS, Shi Q, Lee KH. Antitumor agents. 234. Design, synthesis, and biological evaluation of novel 4β-[(4″-benzamido)-amino]-4′-O-demethyl- epipodophyllotoxin derivatives Journal of Medicinal Chemistry. 47: 5140-5148. PMID 15456257 DOI: 10.1021/jm030609l |
0.601 |
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| 2004 |
Yu DH, Lee KH, Lee JY, Kim S, Shin DM, Kim JH, Lee YS, Lee YS, Oh SK, Moon SY, Lee SH, Lee YS. Changes of gene expression profiles during neuronal differentiation of central nervous system precursors treated with ascorbic acid. Journal of Neuroscience Research. 78: 29-37. PMID 15372504 DOI: 10.1002/Jnr.20220 |
0.449 |
|
| 2004 |
Murakami C, Fukamiya N, Tamura S, Okano M, Bastow KF, Tokuda H, Mukainaka T, Nishino H, Lee KH. Multidrug-resistant cancer cell susceptibility to cytotoxic quassinoids, and cancer chemopreventive effects of quassinoids and canthin alkaloids. Bioorganic & Medicinal Chemistry. 12: 4963-8. PMID 15336275 DOI: 10.1016/j.bmc.2004.06.045 |
0.355 |
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| 2004 |
Hsieh PW, Chang FR, Lee KH, Hwang TL, Chang SM, Wu YC. A new anti-HIV alkaloid, drymaritin, and a new C-glycoside flavonoid, diandraflavone, from Drymaria diandra. Journal of Natural Products. 67: 1175-7. PMID 15270576 DOI: 10.1021/np0400196 |
0.363 |
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| 2004 |
Yu D, Chen CH, Brossi A, Lee KH. Anti-AIDS agents. 60. Substituted 3'R,4'R-di-O-(-)-camphanoyl-2',2'-dimethyldihydropyrano[2,3-f]chromone (DCP) analogues as potent anti-HIV agents. Journal of Medicinal Chemistry. 47: 4072-82. PMID 15267246 DOI: 10.1021/Jm0400505 |
0.615 |
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| 2004 |
Zhu XK, Guan J, Xiao Z, Cosentino LM, Lee KH. Anti-AIDS agents. Part 61: Anti-HIV activity of new podophyllotoxin derivatives. Bioorganic & Medicinal Chemistry. 12: 4267-73. PMID 15246103 DOI: 10.1016/j.bmc.2004.04.048 |
0.621 |
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| 2004 |
Xiao Z, Vance JR, Bastow KF, Brossi A, Wang HK, Lee KH. Antitumor agents. Part 235: Novel 4′-ester etoposide analogues as potent DNA topoisomerase II inhibitors with improved therapeutic potential Bioorganic and Medicinal Chemistry. 12: 3363-3369. PMID 15158805 DOI: 10.1016/j.bmc.2004.03.056 |
0.57 |
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| 2004 |
Xiao Z, Bastow KF, Vance JR, Lee KH. Antitumor agents. Part 227: Studies on novel 4′-O-demethyl- epipodophyllotoxins as antitumor agents targeting topoisomerase II Bioorganic and Medicinal Chemistry. 12: 3339-3344. PMID 15158802 DOI: 10.1016/j.bmc.2004.03.067 |
0.565 |
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| 2004 |
Han S, Xiao Z, Bastow KF, Lee KH. Antitumor agents. Part 230: C4'-esters of GL-331 as cytotoxic agents and DNA topoisomerase II inhibitors. Bioorganic & Medicinal Chemistry Letters. 14: 2979-82. PMID 15125972 DOI: 10.1016/j.bmcl.2004.02.102 |
0.564 |
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| 2004 |
Xiao Z, Han S, Bastow KF, Lee KH. Antitumor agents. Part 232: Synthesis of cyclosulfite podophyllotoxin analogues as novel prototype antitumor agents. Bioorganic & Medicinal Chemistry Letters. 14: 1581-4. PMID 15006408 DOI: 10.1016/j.bmcl.2003.12.096 |
0.59 |
|
| 2004 |
Lee KH. Current Developments in the Discovery and Design of New Drug Candidates from Plant Natural Product Leads Journal of Natural Products. 67: 273-283. PMID 14987069 DOI: 10.1021/Np030373O |
0.436 |
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| 2004 |
Sakurai N, Wu JH, Sashida Y, Mimaki Y, Nikaido T, Koike K, Itokawa H, Lee KH. Anti-AIDS agents. Part 57: Actein, an anti-HIV principle from the rhizome of Cimicifuga racemosa (black cohosh), and the anti-HIV activity of related saponins. Bioorganic & Medicinal Chemistry Letters. 14: 1329-32. PMID 14980692 DOI: 10.1016/j.bmcl.2003.12.035 |
0.375 |
|
| 2004 |
Kuo PC, Damu AG, Lee KH, Wu TS. Cytotoxic and antimalarial constituents from the roots of Eurycoma longifolia. Bioorganic & Medicinal Chemistry. 12: 537-44. PMID 14738962 DOI: 10.1016/J.BMC.2003.11.017 |
0.346 |
|
| 2004 |
Xie L, Yu D, Wild C, Allaway G, Turpin J, Smith PC, Lee KH. Anti-AIDS agents. 52. Synthesis and anti-HIV activity of hydroxymethyl (3'R,4'R)-3',4'-di-O-(S)-camphanoyl-(+)-cis-khellactone derivatives. Journal of Medicinal Chemistry. 47: 756-60. PMID 14736256 DOI: 10.1021/Jm030416Y |
0.619 |
|
| 2004 |
Ding P, Chen D, Bastow KF, Nyarko AK, Wang X, Lee KH. Cytotoxic isoprenylated flavonoids from the roots of Sophora flavescens Helvetica Chimica Acta. 87: 2574-2580. DOI: 10.1002/Hlca.200490230 |
0.396 |
|
| 2003 |
Chang FR, Hayashi KI, Chen IH, Liaw CC, Bastow KF, Nakanishi Y, Nozaki H, Cragg GM, Wu YC, Lee KH. Antitumor Agents. 228. Five New Agarofurans, Reissantins A-E, and Cytotoxic Principles from Reissantia buchananii Journal of Natural Products. 66: 1416-1420. PMID 14640511 DOI: 10.1021/Np030241V |
0.427 |
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| 2003 |
Ohtsu H, Itokawa H, Xiao Z, Su CY, Shih CC, Chiang T, Chang E, Lee Y, Chiu SY, Chang C, Lee KH. Antitumor agents 222. Synthesis and anti-androgen activity of new diarylheptanoids. Bioorganic & Medicinal Chemistry. 11: 5083-90. PMID 14604672 DOI: 10.1016/J.Bmc.2003.08.029 |
0.563 |
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| 2003 |
Hsieh PW, Chang FR, McPhail AT, Lee KH, Wu YC. New cembranolide analogues from the formosan soft coral Sinularia flexibilis and their cytotoxicity. Natural Product Research. 17: 409-18. PMID 14577690 DOI: 10.1080/14786910310001617677 |
0.306 |
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| 2003 |
Golbraikh A, Shen M, Xiao Z, Xiao YD, Lee KH, Tropsha A. Rational selection of training and test sets for the development of validated QSAR models. Journal of Computer-Aided Molecular Design. 17: 241-53. PMID 13677490 DOI: 10.1023/A:1025386326946 |
0.509 |
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| 2003 |
Wu JH, Chang FR, Hayashi Ki, Shiraki H, Liaw CC, Nakanishi Y, Bastow KF, Yu D, Chen IS, Lee KH. Antitumor agents. Part 218: Cappamensin A, a new In vitro anticancer principle, from Capparis sikkimensis. Bioorganic & Medicinal Chemistry Letters. 13: 2223-5. PMID 12798338 DOI: 10.1016/S0960-894X(03)00379-2 |
0.599 |
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| 2003 |
Wu JH, Wang XH, Yi YH, Lee KH. Anti-AIDS agents 54. A potent anti-HIV chalcone and flavonoids from genus Desmos. Bioorganic & Medicinal Chemistry Letters. 13: 1813-5. PMID 12729671 DOI: 10.1016/S0960-894X(03)00197-5 |
0.465 |
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| 2003 |
Yu D, Brossi A, Kilgore N, Wild C, Allaway G, Lee KH. Anti-HIV agents. Part 55: 3'R,4'R-Di-(O)-(-)-camphanoyl-2',2'-dimethyldihydropyrano[2,3-f]chromone (DCP), a novel anti-HIV agent. Bioorganic & Medicinal Chemistry Letters. 13: 1575-6. PMID 12699758 |
0.559 |
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| 2003 |
Ohtsu H, Nakanishi Y, Bastow KF, Lee FY, Lee KH. Antitumor agents 216. Synthesis and evaluation of paclitaxel-camptothecin conjugates as novel cytotoxic agents. Bioorganic & Medicinal Chemistry. 11: 1851-7. PMID 12659771 DOI: 10.1016/S0968-0896(03)00040-3 |
0.374 |
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| 2003 |
Yu D, Suzuki M, Xie L, Morris-Natschke SL, Lee KH. Recent progress in the development of coumarin derivatives as potent anti-HIV agents. Medicinal Research Reviews. 23: 322-45. PMID 12647313 DOI: 10.1002/Med.10034 |
0.701 |
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| 2003 |
Chang YC, Hsieh PW, Chang FR, Wu RR, Liaw CC, Lee KH, Wu YC. Two new protopines argemexicaines A and B and the anti-HIV alkaloid 6-acetonyldihydrochelerythrine from formosan Argemone mexicana. Planta Medica. 69: 148-52. PMID 12624820 DOI: 10.1055/s-2003-37710 |
0.302 |
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| 2003 |
Sun IC, Kashiwada Y, Morris-Natschke SL, Lee KH. Plant-derived terpenoids and analogues as anti-HIV agents. Current Topics in Medicinal Chemistry. 3: 155-69. PMID 12570771 DOI: 10.2174/1568026033392435 |
0.376 |
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| 2003 |
Chen DF, Zhang SX, Kozuka M, Sun QZ, Feng J, Wang Q, Mukainaka T, Nobukuni Y, Tokuda H, Nishino H, Wang HK, Morris-Natschke SL, Lee KH. Interiotherins C and D, two new lignans from Kadsura interior and antitumor-promoting effects of related neolignans on Epstein-Barr virus activation. Journal of Natural Products. 65: 1242-5. PMID 12350139 DOI: 10.1021/Np0105127 |
0.403 |
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| 2003 |
Wu JH, Morris-Natschke SL, Lee K. Progress in the Recent Discovery and Development of Promising Anticancer and Anti-HIV Agents from Natural Products in the United States† Journal of the Chinese Chemical Society. 50: 11-22. DOI: 10.1002/Jccs.200300002 |
0.371 |
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| 2002 |
Bruno M, Rosselli S, Pibiri I, Kilgore N, Lee K. Anti-HIV agents derived from the ent-kaurane diterpenoid linearol. Journal of Natural Products. 65: 1594-1597. PMID 12444682 DOI: 10.1021/Np020029B |
0.462 |
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| 2002 |
Ohtsu H, Xiao Z, Ishida J, Nagai M, Wang HK, Itokawa H, Su CY, Shih C, Chiang T, Chang E, Lee Y, Tsai MY, Chang C, Lee KH. Antitumor agents. 217. Curcumin analogues as novel androgen receptor antagonists with potential as anti-prostate cancer agents. Journal of Medicinal Chemistry. 45: 5037-42. PMID 12408714 DOI: 10.1021/Jm020200G |
0.552 |
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| 2002 |
Han S, Hamel E, Bastow KF, McPhail AT, Brossi A, Lee KH. Antitumor agents. Part 215: antitubulin effects of cytotoxic B-ring modified allocolchicinoids. Bioorganic & Medicinal Chemistry Letters. 12: 2851-3. PMID 12270161 DOI: 10.1016/S0960-894X(02)00635-2 |
0.329 |
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| 2002 |
Shinozaki Y, Fukamiya N, Uchiyama C, Okano M, Tagahara K, Bastow KF, Lee KH. Multidrug resistant cancer cells susceptibility to cytotoxic taxane diterpenes from Taxus yunnanensis and Taxus chinensis. Bioorganic & Medicinal Chemistry Letters. 12: 2785-8. PMID 12217376 DOI: 10.1016/S0960-894X(02)00528-0 |
0.307 |
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| 2002 |
Ishida J, Ohtsu H, Tachibana Y, Nakanishi Y, Bastow KF, Nagai M, Wang HK, Itokawa H, Lee KH. Antitumor agents. Part 214: synthesis and evaluation of curcumin analogues as cytotoxic agents. Bioorganic & Medicinal Chemistry. 10: 3481-7. PMID 12213462 DOI: 10.1016/S0968-0896(02)00249-3 |
0.319 |
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| 2002 |
Sun I, Chen C, Kashiwada Y, Wu J, Wang H, Lee K. Anti-AIDS agents 49. Synthesis, anti-HIV, and anti-fusion activities of IC9564 analogues based on betulinic acid Journal of Medicinal Chemistry. 45: 4271-4275. PMID 12213068 DOI: 10.1021/Jm020069C |
0.475 |
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| 2002 |
Xiao Z, Xiao YD, Feng J, Golbraikh A, Tropsha A, Lee KH. Antitumor agents. 213. Modeling of epipodophyllotoxin derivatives using variable selection k nearest neighbor QSAR method. Journal of Medicinal Chemistry. 45: 2294-309. PMID 12014968 DOI: 10.1021/Jm0105427 |
0.535 |
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| 2002 |
Wongsinkongman P, Brossi A, Wang HK, Bastow KF, Lee KH. Antitumor agents. Part 209: Pheophorbide-a derivatives as photo-Independent cytotoxic agents. Bioorganic & Medicinal Chemistry. 10: 583-91. PMID 11814846 DOI: 10.1016/S0968-0896(01)00305-4 |
0.357 |
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| 2002 |
Hayashi KI, Nakanishi Y, Bastow KF, Cragg G, Nozaki H, Lee KH. Antitumor agents. Part 212: Bucidarasins A-C, three new cytotoxic clerodane diterpenes from Bucida buceras Bioorganic and Medicinal Chemistry Letters. 12: 345-348. PMID 11814793 DOI: 10.1016/S0960-894X(01)00742-9 |
0.328 |
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| 2001 |
Cheng HI, Lin WY, Duh CY, Lee KH, Tsai IL, Chen IS. New cytotoxic butanolides from Litsea acutivena. Journal of Natural Products. 64: 1502-5. PMID 11754599 DOI: 10.1021/Np0102298 |
0.393 |
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| 2001 |
Xia Y, Yang Z, Xia P, Hackl T, Hamel E, Mauger A, Wu J, Lee K. Antitumor agents. 211. Fluorinated 2-phenyl-4-quinolone derivatives as antimitotic antitumor agents Journal of Medicinal Chemistry. 44: 3932-3936. PMID 11689079 DOI: 10.1021/Jm0101085 |
0.482 |
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| 2001 |
Ito J, Chang FR, Wang HK, Park YK, Ikegaki M, Kilgore N, Lee KH. Anti-AIDS agents. 48.(1) Anti-HIV activity of moronic acid derivatives and the new melliferone-related triterpenoid isolated from Brazilian propolis. Journal of Natural Products. 64: 1278-81. PMID 11678650 DOI: 10.1021/Np010211X |
0.452 |
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| 2001 |
Ishida J, Wang HK, Oyama M, Cosentino ML, Hu CQ, Lee KH. Anti-AIDS agents. 46. Anti-HIV activity of harman, an anti-HIV principle from Symplocos setchuensis, and its derivatives. Journal of Natural Products. 64: 958-60. PMID 11473435 DOI: 10.1021/Np0101189 |
0.454 |
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| 2001 |
Cheng HH, Wang HK, Ito J, Bastow KF, Tachibana Y, Nakanishi Y, Xu Z, Luo TY, Lee KH. Cytotoxic pheophorbide-related compounds from Clerodendrum calamitosum and C. cyrtophyllum Journal of Natural Products. 64: 915-919. PMID 11473423 DOI: 10.1021/Np000595B |
0.432 |
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| 2001 |
Mishra L, Sinha R, Itokawa H, Bastow KF, Tachibana Y, Nakanishi Y, Kilgore N, Lee KH. Anti-HIV and cytotoxic activities of Ru(II)/Ru(III) polypyridyl complexes containing 2,6-(2′-benzimidazolyl)-pyridine/chalcone as co-ligand Bioorganic and Medicinal Chemistry. 9: 1667-1671. PMID 11425566 DOI: 10.1016/S0968-0896(01)00074-8 |
0.41 |
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| 2001 |
Kuo YH, Li SY, Huang RL, Wu MD, Huang HC, Lee K. Schizarin B, C, D, and E, Four New Lignans from Kadsura matsudai and Their Antihepatitis Activities Journal of Natural Products. 64: 487-490. PMID 11325232 DOI: 10.1021/Np000261M |
0.422 |
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| 2001 |
VanVliet DS, Tachibana Y, Bastow KF, Huang ES, Lee KH. Antitumor agents. 207. Design, synthesis, and biological testing of 4β-anilino-2-fluoro-4′-demethylpodophyllotoxin analogues as cytotoxic and antiviral agents Journal of Medicinal Chemistry. 44: 1422-1428. PMID 11311065 DOI: 10.1021/Jm000377F |
0.476 |
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| 2001 |
Holz-Smith SL, Sun IC, Jin L, Matthews TJ, Lee KH, Chen CH. Role of human immunodeficiency virus (HIV) type 1 envelope in the anti-HIV activity of the betulinic acid derivative IC9564. Antimicrobial Agents and Chemotherapy. 45: 60-6. PMID 11120945 DOI: 10.1128/Aac.45.1.60-66.2001 |
0.384 |
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| 2000 |
Xu Z, Chang FR, Wang HK, Kashiwada Y, McPhail AT, Bastow KF, Tachibana Y, Cosentino M, Lee KH. Anti-HIV agents 451 and antitumor agents 205.2 Two new sesquiterpenes, leitneridanins A and B, and the cytotoxic and anti-HIV principles from Leitneria floridana Journal of Natural Products. 63: 1712-1715. PMID 11141127 DOI: 10.1021/Np000260U |
0.497 |
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| 2000 |
Kashiwada Y, Nagao T, Hashimoto A, Ikeshiro Y, Okabe H, Cosentino LM, Lee K. Anti-AIDS agents 38. Anti-HIV activity of 3-O-acyl ursolic acid derivatives. Journal of Natural Products. 63: 1619-1622. PMID 11141100 DOI: 10.1021/Np990633V |
0.41 |
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| 2000 |
Hour MJ, Huang LJ, Kuo SC, Xia Y, Bastow K, Nakanishi Y, Hamel E, Lee KH. 6-alkylamino- and 2,3-dihydro-3′-methoxy-2-phenyl-4-quinazolinones and related compounds: Their synthesis, cytotoxicity, and inhibition of tubulin polymerization Journal of Medicinal Chemistry. 43: 4479-4487. PMID 11087572 DOI: 10.1021/Jm000151C |
0.479 |
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| 2000 |
Tachibana Y, Zhu XK, Krishnan P, Lee KH, Bastow KF. Characterization of human lung cancer cells resistant to 4'-O-demethyl-4beta-(2"-nitro-4"-fluoroanilino)-4-desoxypodophyllotoxin , a unique compound in the epipodophyllotoxin antitumor class. Anti-Cancer Drugs. 11: 19-28. PMID 10757559 DOI: 10.1097/00001813-200001000-00004 |
0.425 |
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| 1999 |
Lee K. Novel antitumor agents from higher plants. Medicinal Research Reviews. 19: 569-596. PMID 10557371 DOI: 10.1002/(Sici)1098-1128(199911)19:6<569::Aid-Med7>3.0.Co;2-9 |
0.478 |
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| 1999 |
Chao YH, Kuo SC, Ku K, Chiu IP, Wu CH, Mauger A, Wang HK, Lee KH. Synthesis and cytotoxicity of methyl-4,8-dihydrobenzo[1,2-b:5,4-b']dithiophene-4,8-dione derivatives. Bioorganic & Medicinal Chemistry. 7: 1025-31. PMID 10428370 DOI: 10.1016/S0968-0896(98)00241-7 |
0.379 |
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| 1999 |
Zhu XK, Guan J, Tachibana Y, Bastow KF, Sung Jin Cho, Cheng H.- H, Cheng YC, Gurwith M, Lee KH. Antitumor agents. 194. Synthesis and biological evaluations of 4-β- mono-, -di-, and -trisubstituted aniline-4'-O-demethyl-podophyllotoxin and related compounds with improved pharmacological profiles Journal of Medicinal Chemistry. 42: 2441-2446. PMID 10395485 DOI: 10.1021/Jm990055F |
0.425 |
|
| 1999 |
Fujioka T, Yamamoto M, Kashiwada Y, Fujii H, Mihashi K, Ikeshiro Y, Chen IS, Lee KH. Novel cytotoxic diterpenes from the stem of Dysoxylum kuskusense. Bioorganic & Medicinal Chemistry Letters. 8: 3479-82. PMID 9934456 DOI: 10.1016/S0960-894X(98)00630-1 |
0.414 |
|
| 1999 |
Lee K, Morris-Natschke SL. Recent advances in the discovery and development of plant-derived natural products and their analogs as anti-HIV agents Pure and Applied Chemistry. 71: 1045-1051. DOI: 10.1351/Pac199971061045 |
0.463 |
|
| 1998 |
Yang ZY, Xia Y, Xia P, Cosentino LM, Lee K. Anti-AIDS agents. 31. Synthesis and anti-HIV activity of 4-substituted 3',4'-di-O-(-)-camphanoyl-(+)-cis-khellactone (DCK) thiolactone analogs. Bioorganic & Medicinal Chemistry Letters. 8: 1483-1486. PMID 9873374 DOI: 10.1016/S0960-894X(98)00254-6 |
0.437 |
|
| 1998 |
Sun IC, Shen JK, Wang HK, Cosentino LM, Lee KH. Anti-AIDS agents. 32.1 Synthesis and anti-HIV activity of betulin derivatives Bioorganic and Medicinal Chemistry Letters. 8: 1267-1272. PMID 9871747 DOI: 10.1016/S0960-894X(98)00202-9 |
0.481 |
|
| 1998 |
Guan J, Zhu XK, Tachibana Y, Bastow KF, Brossi A, Hamel E, Lee KH. Antitumor agents. 185. Synthesis and biological evaluation of tridemethylthiocolchicine analogues as novel topoisomerase II inhibitors Journal of Medicinal Chemistry. 41: 1956-1961. PMID 9599244 DOI: 10.1021/Jm980007F |
0.474 |
|
| 1998 |
Shi Q, Chen K, Brossi A, Verdier-Pinard P, Hamel E, McPhail AT, Lee K. Antitumor Agents. Part 184. Syntheses and antitubulin activity of compounds derived from reaction of thiocolchicone with amines: Lactams, alcohols, and ester analogs of allothiocolchicinoids†‡ Helvetica Chimica Acta. 81: 1023-1037. DOI: 10.1002/Hlca.19980810516 |
0.37 |
|
| 1997 |
Lien J, Huang L, Wang J, Teng C, Lee K, Kuo S. Synthesis and antiplatelet, antiinflammatory, and antiallergic activities of 2-substituted 3-chloro-1,4-naphthoquinone derivatives Bioorganic & Medicinal Chemistry. 5: 2111-2120. PMID 9459008 DOI: 10.1016/S0968-0896(97)00133-8 |
0.426 |
|
| 1997 |
Zeng JF, Li GL, Shen JK, Zhu DY, Chen K, Lee KH. Manuifolins D, E, and F: New isoflavonoids from Maackia tenuifolia Journal of Natural Products. 60: 918-920. PMID 9322365 DOI: 10.1021/Np970173A |
0.31 |
|
| 1996 |
Kuo S, Ibuka T, Huang L, Lien J, Yean S, Huang S, Lednicer D, Morris-Natschke S, Lee K. Synthesis and Cytotoxicity of 1,2-Disubstituted Naphth[2,3-d]imidazole-4,9-diones and Related Compounds Journal of Medicinal Chemistry. 39: 1447-1451. PMID 8691475 DOI: 10.1021/Jm950247K |
0.479 |
|
| 1996 |
Cho SJ, Tropsha A, Sufness M, Cheng YC, Lee KH. Antitumor agents. 163. Three-dimensional quantitative structure-activity relationship study of 4′-O-demethylepipodophyllotoxin analogs using the modified CoMFA/q2-GRS approach Journal of Medicinal Chemistry. 39: 1383-1395. PMID 8691468 DOI: 10.1021/Jm9503052 |
0.334 |
|
| 1996 |
Kashiwada Y, Hashimoto F, Cosentino LM, Chen C, Garrett PE, Lee K. Betulinic acid and dihydrobetulinic acid derivatives as potent anti-HIV agents Journal of Medicinal Chemistry. 39: 1016-1017. PMID 8676334 DOI: 10.1021/Jm950922Q |
0.386 |
|
| 1996 |
Hashimoto F, Kashiwada Y, Nonaka GI, Nishioka I, Nohara T, Cosentino LM, Lee K. Evaluation of tea polyphenols as anti-HIV agents Bioorganic & Medicinal Chemistry Letters. 6: 695-700. DOI: 10.1016/0960-894X(96)00095-9 |
0.425 |
|
| 1995 |
Chen K, Shi Q, Fujioka T, Nakano T, Hu CQ, Jin JQ, Kilkuskie RE, Lee K. Anti-AIDS agents--XIX. Neotripterifordin, a novel anti-HIV principle from Tripterygium wilfordii: isolation and structural elucidation. Bioorganic & Medicinal Chemistry. 3: 1345-1348. PMID 8564400 DOI: 10.1016/0968-0896(95)00114-V |
0.454 |
|
| 1995 |
Zhang S, Chen K, Liu X, Zhang D, Tao-Wiedmann T, Leu S, McPhail aAT, Lee K. The Isolation and Structural Elucidation of Three New Neolignans, Puberulins A, B, and C, as Platelet Activating Factor Receptor Antagonists from Piper puberulum Journal of Natural Products. 58: 540-547. PMID 7623032 DOI: 10.1021/Np50118A009 |
0.353 |
|
| 1995 |
Xie L, Xie J, Kashiwada Y, Cosentino LM, Liu S, Pai RB, Cheng Y, Lee K. Anti-AIDS (Acquired Immune Deficiency Syndrome) Agents. 17. New Brominated Hexahydroxybiphenyl Derivatives as Potent Anti-HIV Agents Journal of Medicinal Chemistry. 38: 3003-3008. PMID 7543578 DOI: 10.1021/Jm00016A002 |
0.462 |
|
| 1994 |
Kuo YH, King ML, Chen CF, Chen HY, Chen CH, Chen K, Lee KH. Two new macrolide sesquiterpene pyridine alkaloids from Maytenus emarginata: emarginatine G and the cytotoxic emarginatine F. Journal of Natural Products. 57: 263-9. PMID 8176403 DOI: 10.1021/Np50104A011 |
0.35 |
|
| 1994 |
Fujioka T, Kashiwada Y, Kilkuskie RE, Cosentino LM, Ballas LM, Jiang JB, Janzen WP, Chen I, Lee K. Anti-AIDS agents, 11. Betulinic acid and platanic acid as anti-HIV principles from Syzigium claviflorum, and the anti-HIV activity of structurally related triterpenoids. Journal of Natural Products. 57: 243-247. PMID 8176401 DOI: 10.1021/Np50104A008 |
0.448 |
|
| 1994 |
Huang L, Kashiwada Y, Cosentino LM, Fan S, Chen C, Mcphail AT, Fujioka T, Mihashi K, Lee K. Anti-AIDS Agents. 15. Synthesis and Anti-HIV Activity of Dihydroseselins and Related Analogs Journal of Medicinal Chemistry. 37: 3947-3955. PMID 7525962 DOI: 10.1021/Jm00049A014 |
0.495 |
|
| 1994 |
Huang L, Kashiwada Y, Cosentino LM, Fan S, Lee K. 3′,4′-Di-o-(-)-camphanoyl-(+)-ciskhellactone and related compounds: A. new class of potent anti-HIV agents Bioorganic & Medicinal Chemistry Letters. 4: 593-598. DOI: 10.1016/S0960-894X(01)80161-X |
0.503 |
|
| 1993 |
Zhou X, Wang Z, Chen H, Cheng Y, Lee K. Antitumor Agents. 125. New 4β-Benzoylamino Derivatives of 4′-O-Demethyl-4-desoxypodophyllotoxin and 4β-Benzoyl Derivatives of 4′-O-Demethylpodophyllotoxin as Potent Inhibitors of Human DNA Topoisomerase II Pharmaceutical Research. 10: 214-219. PMID 8384366 DOI: 10.1023/A:1018978525533 |
0.333 |
|
| 1993 |
Konoshima T, Takasaki M, Kozuka M, Haruna M, Ito K, Estes JR, Lee KH. Constituents of rosaceous plants. I. Structures of new triterpenoids from Cowania mexicana Chemical and Pharmaceutical Bulletin. 41: 1612-1615. PMID 8221976 DOI: 10.1248/Cpb.41.1612 |
0.308 |
|
| 1993 |
Terada H, Kokumai M, Konoshima T, Kozuka M, Haruna M, Ito K, Estes JR, Li L, Wang H, Lee K. Structural Elucidation and Chemical Conversion of Amorphispironone, a Novel Spironone form Amorpha fruticosa, to Rotenoids Chemical & Pharmaceutical Bulletin. 41: 187-190. DOI: 10.1248/Cpb.41.187 |
0.38 |
|
| 1993 |
Bastow KF, Tatematsu H, Bori ID, Fukushima Y, Sun L, Goz B, Lee KH. Induction of reversible protein-linked DNA breaks in human osteogenic sarcoma cells by novel cytocidal colchicine derivatives which inhibit DNA topoisomerase II in vitro: Absence of cross-resistance in a colchicine-resistant sub-clone Bioorganic and Medicinal Chemistry Letters. 3: 1045-1050. DOI: 10.1016/S0960-894X(00)80284-X |
0.313 |
|
| 1990 |
Pan D, Li Z, Hu C, Chen K, Chang J, Lee K. The cytotoxic principles of Pseudolarix kaempferi : pseudolaric acid-A and -B and related derivatives Planta Medica. 56: 383-385. PMID 2236294 DOI: 10.1055/S-2006-960989 |
0.344 |
|
| 1989 |
Lee KH, Lin YM, Wu TS, Zhang DC, Yamagishi T, Hayashi T, Hall IH, Chang JJ, Wu RY, Yang TH. The cytotoxic principles of Prunella vulgaris, Psychotria serpens, and Hyptis capitata: ursolic acid and related derivatives. Planta Medica. 54: 308-11. PMID 3222376 DOI: 10.1055/S-2006-962441 |
0.304 |
|
| 1989 |
Lee K, Imakura Y, Haruna M, Beers SA, Thurston LS, Dai H, Chen C, Liu S, Cheng Y. Antitumor agents, 107. New cytotoxic 4-alkylamino analogues of 4'-demethyl-epipodophyllotoxin as inhibitors of human DNA topoisomerase II. Journal of Natural Products. 52: 606-613. PMID 2550587 DOI: 10.1021/Np50063A021 |
0.345 |
|
| 1989 |
Parker WB, Nishizawa M, Fisher MH, Ye N, Lee KH, Cheng YC. Characterization of a novel inhibitor of human DNA polymerases: 3,4,5-tri-O-galloylquinic acid. Biochemical Pharmacology. 38: 3759-65. PMID 2480788 DOI: 10.1016/0006-2952(89)90582-0 |
0.315 |
|
| 1988 |
Yamagashi T, Yan X, Wu R, Mcphail DR, Mcphail AT, Lee K. Structure and stereochemistry of bryophyllin-A, a novel potent cytotoxic bufadienolide orthoacetate from Bryophyllum pinnatum Chemical & Pharmaceutical Bulletin. 36: 1615-1617. PMID 3416378 DOI: 10.1248/Cpb.36.1615 |
0.316 |
|
| 1988 |
Yokoi T, Yang L, Wu R, Lee K. Neihumicin, a new cytotoxic antibiotic from Micromonospora neihuensis. III. Structure-activity relationships. The Journal of Antibiotics. 41: 494-501. PMID 3372356 DOI: 10.7164/Antibiotics.41.494 |
0.344 |
|
| 1988 |
Wu R, Yang L, Yokoi T, Lee K. Neihumicin, a new cytotoxic antibiotic from Micromonospora neihuensis. I: The producing organism, fermentation, isolation and biological properties The Journal of Antibiotics. 41: 481-487. PMID 3372354 DOI: 10.7164/Antibiotics.41.481 |
0.311 |
|
| 1987 |
Fukamiya N, Okano M, Aratani T, Negoro K, Lin Y, Lee K. Antitumor agents: LXXXVII. Cytotoxic antileukemic canthin-6-one alkaloids from Brucea antidysenterica and the structure activity relationships of their related derivatives. Planta Medica. 53: 140-143. PMID 3602137 DOI: 10.1055/S-2006-962656 |
0.386 |
|
| 1987 |
Zhao Y, Hall IH, Oswald CB, Yokoi T, Lee KH. Antimalarial agents. III. Mechanism of action of artesunate against Plasmodium berghei infection. Chemical & Pharmaceutical Bulletin. 35: 2052-61. PMID 3311413 DOI: 10.1248/Cpb.35.2052 |
0.341 |
|
| 1986 |
Nozaki H, Suzuki H, Hirayama T, Kasai R, Wu RY, Lee K. Antitumour triterpenes of Maytenus diversifolia Phytochemistry. 25: 479-485. DOI: 10.1016/S0031-9422(00)85505-3 |
0.336 |
|
| 1985 |
Lin Y, Juichi M, Wu R, Lee K. Antitumor agents. LXIX. Alkaloids of Ochrosia acuminata. Planta Medica. 51: 545-546. PMID 17345297 DOI: 10.1055/S-2007-969602 |
0.316 |
|
| 1984 |
Levy RK, Hall IH, Lee KH. Antitumor agents LXII: synthesis and biological evaluation of podophyllotoxin esters and related derivatives. Journal of Pharmaceutical Sciences. 72: 1158-61. PMID 6644563 DOI: 10.1002/Chin.198414217 |
0.403 |
|
| 1983 |
CONSIDINE RT, WILLINGHAM W, CHANEY SG, WYRICK S, HALL IH, LEE K‐. Structure‐Activity Relationships for Binding and Inactivation of Rabbit Reticulocyte Ribosomes by Quassinoid Antineoplastic Agents European Journal of Biochemistry. 132: 157-163. PMID 6840079 DOI: 10.1111/J.1432-1033.1983.Tb07341.X |
0.4 |
|
| 1982 |
Lee KH, Okano M, Hall IH, Brent DA, Soltmann B. Antitumor agents XLV: Bisbrusatolyl and brusatolyl esters and related compounds as novel potent antileukemic agents. Journal of Pharmaceutical Sciences. 71: 338-45. PMID 7069595 DOI: 10.1002/Jps.2600710320 |
0.42 |
|
| 1980 |
Lee KH, Ibuka T, Furukawa H, Kozuka M, Wu RY, Hall IH, Huang HC. Antitumor agents XXXVIII: Isolation and structural elucidation of novel germacranolides and triterpenes from Elephantopus mollis. Journal of Pharmaceutical Sciences. 69: 1050-6. PMID 7411406 DOI: 10.1002/Jps.2600690917 |
0.378 |
|
| 1980 |
Imakura Y, Lee KH, Sims D, Wu RY, Hall IH, Furukawa H, Itoigawa M, Yonaha K. Antitumor agents XXXVI: Structural elucidation of sesquiterpene lactones microhelenins-A, B, and C, microlenin acetate, and plenolin from Helenium microcephalum. Journal of Pharmaceutical Sciences. 69: 1044-9. PMID 7411405 DOI: 10.1002/Jps.2600690916 |
0.339 |
|
| 1979 |
Ito K, Sakakibara Y, Haruna M, Lee K. Four New Germacranolides From Eupatorium Lindleyanum Dc. Chemistry Letters. 8: 1469-1472. DOI: 10.1246/Cl.1979.1469 |
0.316 |
|
| 1978 |
Hall IH, Lee KH, Starnes CO, Eigebaly SA, Ibuka T, Wu YS, Kimura T, Haruna M. Antitumor agents XXX: Evaluation of alpha-methylene-gamma-lactone-containing agents for inhibition of tumor growth, respiration, and nucleic acid synthesis. Journal of Pharmaceutical Sciences. 67: 1235-9. PMID 690826 DOI: 10.1002/Jps.2600670912 |
0.335 |
|
| 1978 |
Hall IH, Lee KH, Eigebaly SA. Antitumor agents XXIX: Effects of eupahyssopin on nucleic acid, protein, anaerobic, and aerobic metabolism of Ehrlich ascites tumor cells. Journal of Pharmaceutical Sciences. 67: 1232-5. PMID 690825 DOI: 10.1002/Jps.2600670911 |
0.362 |
|
| 1978 |
Imakura Y, Lee KH, Sims D, Hall IH. Antitumor agents XXVIII: Structural elucidation of the novel antitumor sesquiterpene lactone, microlenin, from Helenium microcephalum. Journal of Pharmaceutical Sciences. 67: 1228-32. PMID 690824 DOI: 10.1002/Jps.2600670910 |
0.336 |
|
| 1977 |
Lee KH, Haruna M, Huang HC, Wu BS, Hall IH. Antitumor agents XXIII: Helenalin, and antitumor principle from Anaphalis morrisonicola HAY. Journal of Pharmaceutical Sciences. 66: 1194-5. PMID 561183 DOI: 10.1002/Jps.2600660836 |
0.322 |
|
| 1976 |
Lee K, Imakura Y, Sims D. Antitumor Agents XVII: Structure and Stereochemistry of Microhelenin-A, a New Antitumor Sesquiterpene Lactone from Helenium microcephalum Journal of Pharmaceutical Sciences. 65: 1410-1412. PMID 966167 DOI: 10.1002/Jps.2600650940 |
0.348 |
|
| 1975 |
Wolo MT, Cowherd CM, Lee K. Antitumor Agents XV: Deoxyelephantopin, an Antitumor Principle from Elephantopus carolinianus Willd Journal of Pharmaceutical Sciences. 64: 1572-1573. PMID 1185584 DOI: 10.1002/Jps.2600640938 |
0.331 |
|
| 1975 |
Lee K, Ibuka T, Huang H, Harris DL. Antitumor agents XIV: Molephantinin, a new potent antitumor Sesquiterpene lactone from Elephantopus mollis Journal of Pharmaceutical Sciences. 64: 1077-1078. PMID 1169316 DOI: 10.1002/Jps.2600640656 |
0.374 |
|
| 1974 |
Lee KH, Kim SH, Piantadosi C, Huang ES, Geissman TA. Antitumor agents. 8. Synthesis and cytotoxic activity of O,O'-bis(acrylyl)-alpha,omega-alkanediols. Journal of Pharmaceutical Sciences. 63: 1162-3. PMID 4850611 DOI: 10.1002/Jps.2600630734 |
0.361 |
|
| 1973 |
Lee KH, Meck R, Piantadosi C, Huang ES. Antitumor agents. 4. Cytotoxicity and in vitro activity of helenalin esters and related derivatives. Journal of Medicinal Chemistry. 16: 299-301. PMID 4733115 DOI: 10.1021/Jm00261A034 |
0.407 |
|
| 1973 |
Lee KH. Antitumor agents. V. Effect of epoxidation on cytotoxicity of helenalin-related derivatives Journal of Pharmaceutical Sciences. 62: 1028-1029. PMID 4712614 DOI: 10.1002/Jps.2600620645 |
0.375 |
|
| 1972 |
Lee K, Furukawa H, Huang H, Huang E. Antitumor Agents II: Eupatolide, a New Cytotoxic Principle from Eupatorium formosanum HAY Journal of Pharmaceutical Sciences. 61: 629-631. PMID 4335375 DOI: 10.1002/Jps.2600610432 |
0.359 |
|
| 1972 |
Lee KH, Anuforo DC, Huang ES, Piantadosi C. Antitumor agents. I. Augustibalin, a new cytotoxic sesquiterpene lactone from Balduina angustifolia (Pursh.) Robins. Journal of Pharmaceutical Sciences. 61: 626-8. PMID 4335374 DOI: 10.1002/Jps.2600610431 |
0.391 |
|
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