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Virginia Man-Yee Lee, PhD, MBA - Publications

Affiliations: 
Pathology University of Pennsylvania, Philadelphia, PA, United States 
Area:
tau, dementia, neurodegeneration
Website:
http://www.med.upenn.edu/cndr/VMYLeebio.shtml

500 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2022 Hur SK, Hunter M, Dominique MA, Farag M, Cotton-Samuel D, Khan T, Trojanowski JQ, Spiller KJ, Lee VM. Slow motor neurons resist pathological TDP-43 and mediate motor recovery in the rNLS8 model of amyotrophic lateral sclerosis. Acta Neuropathologica Communications. 10: 75. PMID 35568882 DOI: 10.1186/s40478-022-01373-0  0.63
2022 Franzmeier N, Brendel M, Beyer L, Slemann L, Kovacs GG, Arzberger T, Kurz C, Respondek G, Lukic MJ, Biel D, Rubinski A, Frontzkowski L, Hummel S, Müller A, Finze A, ... ... Lee VM, et al. Tau deposition patterns are associated with functional connectivity in primary tauopathies. Nature Communications. 13: 1362. PMID 35292638 DOI: 10.1038/s41467-022-28896-3  0.712
2022 Marshall CA, McBride JD, Changolkar L, Riddle DM, Trojanowski JQ, Lee VM. Inhibition of CK2 mitigates Alzheimer's tau pathology by preventing NR2B synaptic mislocalization. Acta Neuropathologica Communications. 10: 30. PMID 35246269 DOI: 10.1186/s40478-022-01331-w  0.437
2022 Marotta NP, Lee VM. Modeling the cellular fate of alpha-synuclein aggregates: A pathway to pathology. Current Opinion in Neurobiology. 72: 171-177. PMID 35131527 DOI: 10.1016/j.conb.2022.01.003  0.336
2021 Steinkellner T, Conrad WS, Kovacs I, Rissman RA, Lee EB, Trojanowski JQ, Freyberg Z, Roy S, Luk KC, Lee VM, Hnasko TS. Dopamine neurons exhibit emergent glutamatergic identity in Parkinson's disease. Brain : a Journal of Neurology. PMID 35258081 DOI: 10.1093/brain/awab373  0.741
2021 Uemura MT, Robinson JL, Cousins KAQ, Tropea TF, Kargilis DC, McBride JD, Suh E, Xie SX, Xu Y, Porta S, Uemura N, Van Deerlin VM, Wolk DA, Irwin DJ, Brunden KR, ... Lee VM, et al. Distinct characteristics of limbic-predominant age-related TDP-43 encephalopathy in Lewy body disease. Acta Neuropathologica. PMID 34854996 DOI: 10.1007/s00401-021-02383-3  0.628
2021 Marotta NP, Ara J, Uemura N, Lougee MG, Meymand ES, Zhang B, Petersson EJ, Trojanowski JQ, Lee VM. Alpha-synuclein from patient Lewy bodies exhibits distinct pathological activity that can be propagated in vitro. Acta Neuropathologica Communications. 9: 188. PMID 34819159 DOI: 10.1186/s40478-021-01288-2  0.419
2021 Delizannis AT, Nonneman A, Tsering W, De Bondt A, Van den Wyngaert I, Zhang B, Meymand E, Olufemi MF, Koivula P, Maimaiti S, Trojanowski JQ, Lee VM, Brunden KR. Effects of microglial depletion and TREM2 deficiency on Aβ plaque burden and neuritic plaque tau pathology in 5XFAD mice. Acta Neuropathologica Communications. 9: 150. PMID 34503586 DOI: 10.1186/s40478-021-01251-1  0.44
2021 Hunter M, Spiller KJ, Dominique MA, Xu H, Hunter FW, Fang TC, Canter RG, Roberts CJ, Ransohoff RM, Trojanowski JQ, Lee VM. Microglial transcriptome analysis in the rNLS8 mouse model of TDP-43 proteinopathy reveals discrete expression profiles associated with neurodegenerative progression and recovery. Acta Neuropathologica Communications. 9: 140. PMID 34412701 DOI: 10.1186/s40478-021-01239-x  0.665
2021 Puentes LN, Lengyel-Zhand Z, Lee JY, Hsieh CJ, Schneider ME, Edwards KJ, Luk KC, Lee VM, Trojanowski JQ, Mach RH. Poly (ADP-ribose) Interacts With Phosphorylated α-Synuclein in Post Mortem PD Samples. Frontiers in Aging Neuroscience. 13: 704041. PMID 34220490 DOI: 10.3389/fnagi.2021.704041  0.363
2021 Porta S, Xu Y, Lehr T, Zhang B, Meymand E, Olufemi M, Stieber A, Lee EB, Trojanowski JQ, Lee VM. Distinct Brain-derived TDP-43 Strains from FTLD-TDP Subtypes Induce Diverse Morphological TDP-43 Aggregates and Spreading Patterns in vitro and in vivo. Neuropathology and Applied Neurobiology. PMID 33971027 DOI: 10.1111/nan.12732  0.61
2021 Zhang JV, Irwin DJ, Blennow K, Zetterberg H, Lee EB, Shaw LM, Rascovsky K, Massimo L, McMillan CT, Chen-Plotkin A, Elman L, Lee VM, McCluskey L, Toledo JB, Weintraub D, et al. Neurofilament Light Chain Related to Longitudinal Decline in Frontotemporal Lobar Degeneration. Neurology. Clinical Practice. 11: 105-116. PMID 33842063 DOI: 10.1212/CPJ.0000000000000959  0.754
2021 Maeda J, Minamihisamatsu T, Shimojo M, Zhou X, Ono M, Matsuba Y, Ji B, Ishii H, Ogawa M, Akatsu H, Kaneda D, Hashizume Y, Robinson JL, Lee VM, Saito T, et al. Distinct microglial response against Alzheimer's amyloid and tau pathologies characterized by P2Y12 receptor. Brain Communications. 3: fcab011. PMID 33644757 DOI: 10.1093/braincomms/fcab011  0.48
2021 Oukoloff K, Nzou G, Varricchio C, Lucero B, Alle T, Kovalevich J, Monti L, Cornec AS, Yao Y, James MJ, Trojanowski JQ, Lee VM, Smith AB, Brancale A, Brunden KR, et al. Evaluation of the Structure-Activity Relationship of Microtubule-Targeting 1,2,4-Triazolo[1,5-]pyrimidines Identifies New Candidates for Neurodegenerative Tauopathies. Journal of Medicinal Chemistry. PMID 33411523 DOI: 10.1021/acs.jmedchem.0c01605  0.382
2021 Xu H, O'Reilly M, Gibbons GS, Changolkar L, McBride JD, Riddle DM, Zhang B, Stieber A, Nirschl J, Kim SJ, Hoxha KH, Brunden KR, Schellenberg GD, Trojanowski JQ, Lee VM. In vitro amplification of pathogenic tau conserves disease-specific bioactive characteristics. Acta Neuropathologica. PMID 33385254 DOI: 10.1007/s00401-020-02253-4  0.446
2021 Bassil F, Meymand ES, Brown HJ, Xu H, Cox TO, Pattabhiraman S, Maghames CM, Wu Q, Zhang B, Trojanowski JQ, Lee VM. α-Synuclein modulates tau spreading in mouse brains. The Journal of Experimental Medicine. 218. PMID 33091110 DOI: 10.1084/jem.20192193  0.637
2020 Robinson JL, Richardson H, Xie SX, Suh E, Van Deerlin VM, Alfaro B, Loh N, Porras-Paniagua M, Nirschl JJ, Wolk D, Lee VM, Lee EB, Trojanowski JQ. The development and convergence of co-pathologies in Alzheimer's disease. Brain : a Journal of Neurology. PMID 33449993 DOI: 10.1093/brain/awaa438  0.642
2020 Wu Q, Shaikh MA, Meymand ES, Zhang B, Luk KC, Trojanowski JQ, Lee VM. Neuronal activity modulates alpha-synuclein aggregation and spreading in organotypic brain slice cultures and in vivo. Acta Neuropathologica. PMID 33021680 DOI: 10.1007/s00401-020-02227-6  0.587
2020 Yao Y, Nzou G, Alle T, Tsering W, Maimaiti S, Trojanowski JQ, Lee VM, Ballatore C, Brunden KR. Correction of microtubule defects within Aβ plaque-associated dystrophic axons results in lowered Aβ release and plaque deposition. Alzheimer's & Dementia : the Journal of the Alzheimer's Association. PMID 32918367 DOI: 10.1002/Alz.12144  0.462
2020 Robinson JL, Porta S, Garrett FG, Zhang P, Xie SX, Suh E, Van Deerlin VM, Abner EL, Jicha GA, Barber JM, Lee VM, Lee EB, Trojanowski JQ, Nelson PT. Limbic-predominant age-related TDP-43 encephalopathy differs from frontotemporal lobar degeneration. Brain : a Journal of Neurology. PMID 32830216 DOI: 10.1093/Brain/Awaa219  0.622
2020 Cornblath EJ, Robinson JL, Irwin DJ, Lee EB, Lee VM, Trojanowski JQ, Bassett DS. Defining and predicting transdiagnostic categories of neurodegenerative disease. Nature Biomedical Engineering. PMID 32747831 DOI: 10.1038/S41551-020-0593-Y  0.634
2020 Kovacs GG, Robinson JL, Perl DP, Lee VM, Trojanowski JQ. Thorn-shaped astrocytes in the depth of cortical sulci in Western Pacific ALS/Parkinsonism-Dementia complex. Acta Neuropathologica. PMID 32662040 DOI: 10.1007/S00401-020-02192-0  0.344
2020 Riad A, Lengyel-Zhand Z, Zeng C, Weng CC, Lee VM, Trojanowski JQ, Mach RH. The Sigma-2 Receptor/TMEM97, PGRMC1, and LDL Receptor Complex Are Responsible for the Cellular Uptake of Aβ42 and Its Protein Aggregates. Molecular Neurobiology. PMID 32572762 DOI: 10.1007/S12035-020-01988-1  0.385
2020 Arena JD, Smith DH, Lee EB, Gibbons GS, Irwin DJ, Robinson JL, Lee VM, Trojanowski JQ, Stewart W, Johnson VE. Tau immunophenotypes in chronic traumatic encephalopathy recapitulate those of ageing and Alzheimer's disease. Brain : a Journal of Neurology. PMID 32390044 DOI: 10.1093/Brain/Awaa071  0.672
2020 Kovacs GG, Lukic MJ, Irwin DJ, Arzberger T, Respondek G, Lee EB, Coughlin D, Giese A, Grossman M, Kurz C, McMillan CT, Gelpi E, Compta Y, van Swieten JC, Laat LD, ... ... Lee VM, et al. Distribution patterns of tau pathology in progressive supranuclear palsy. Acta Neuropathologica. PMID 32383020 DOI: 10.1007/S00401-020-02158-2  0.708
2020 Uemura N, Uemura MT, Luk KC, Lee VM, Trojanowski JQ. Cell-to-Cell Transmission of Tau and α-Synuclein. Trends in Molecular Medicine. PMID 32371172 DOI: 10.1016/J.Molmed.2020.03.012  0.444
2020 Takeuchi H, Imamura K, Ji B, Tsukita K, Enami T, Takao K, Miyakawa T, Hasegawa M, Sahara N, Iwata N, Inoue M, Hara H, Tabira T, Ono M, Trojanowski JQ, ... Lee VM, et al. Nasal vaccine delivery attenuates brain pathology and cognitive impairment in tauopathy model mice. Npj Vaccines. 5: 28. PMID 32219000 DOI: 10.1038/s41541-020-0172-y  0.424
2020 Peng C, Trojanowski JQ, Lee VM. Protein transmission in neurodegenerative disease. Nature Reviews. Neurology. PMID 32203399 DOI: 10.1038/S41582-020-0333-7  0.613
2020 Lengyel-Zhand Z, Ferrie JJ, Janssen B, Hsieh CJ, Graham T, Xu KY, Haney CM, Lee VM, Trojanowski JQ, Petersson EJ, Mach RH. Synthesis and characterization of high affinity fluorogenic α-synuclein probes. Chemical Communications (Cambridge, England). PMID 32104795 DOI: 10.1039/C9Cc09849F  0.312
2020 Roy ER, Wang B, Wan YW, Chiu GS, Cole AL, Yin Z, Propson NE, Xu Y, Jankowsky JL, Liu Z, Lee VM, Trojanowski JQ, Ginsberg SD, Butovsky O, Zheng H, et al. Type I interferon response drives neuroinflammation and synapse loss in Alzheimer disease. The Journal of Clinical Investigation. PMID 31917687 DOI: 10.1172/Jci133737  0.434
2020 He Z, McBride JD, Xu H, Changolkar L, Kim SJ, Zhang B, Narasimhan S, Gibbons GS, Guo JL, Kozak M, Schellenberg GD, Trojanowski JQ, Lee VM. Transmission of tauopathy strains is independent of their isoform composition. Nature Communications. 11: 7. PMID 31911587 DOI: 10.1038/S41467-019-13787-X  0.807
2019 Robinson JL, Yan N, Caswell C, Xie SX, Suh E, Van Deerlin VM, Gibbons G, Irwin DJ, Grossman M, Lee EB, Lee VM, Miller B, Trojanowski JQ. Primary Tau Pathology, Not Copathology, Correlates With Clinical Symptoms in PSP and CBD. Journal of Neuropathology and Experimental Neurology. PMID 31999351 DOI: 10.1093/Jnen/Nlz141  0.72
2019 Bassil F, Brown HJ, Pattabhiraman S, Iwasyk JE, Maghames CM, Meymand ES, Cox TO, Riddle DM, Zhang B, Trojanowski JQ, Lee VM. Amyloid-Beta (Aβ) Plaques Promote Seeding and Spreading of Alpha-Synuclein and Tau in a Mouse Model of Lewy Body Disorders with Aβ Pathology. Neuron. PMID 31759806 DOI: 10.1016/J.Neuron.2019.10.010  0.471
2019 Caswell C, McMillan CT, Xie SX, Van Deerlin VM, Suh E, Lee EB, Trojanowski JQ, Lee VM, Irwin DJ, Grossman M, Massimo LM. Genetic predictors of survival in behavioral variant frontotemporal degeneration. Neurology. PMID 31537715 DOI: 10.1212/Wnl.0000000000008387  0.614
2019 Uemura N, Uemura MT, Lo A, Bassil F, Zhang B, Luk KC, Lee VM, Takahashi R, Trojanowski JQ. Slow Progressive Accumulation of Oligodendroglial Alpha-Synuclein (α-Syn) Pathology in Synthetic α-Syn Fibril-Induced Mouse Models of Synucleinopathy. Journal of Neuropathology and Experimental Neurology. PMID 31504665 DOI: 10.1093/Jnen/Nlz070  0.368
2019 Prokop S, Miller KR, Labra SR, Pitkin RM, Hoxha K, Narasimhan S, Changolkar L, Rosenbloom A, Lee VM, Trojanowski JQ. Impact of TREM2 risk variants on brain region-specific immune activation and plaque microenvironment in Alzheimer's disease patient brain samples. Acta Neuropathologica. PMID 31350575 DOI: 10.1007/S00401-019-02048-2  0.813
2019 Cali CP, Patino M, Tai YK, Ho WY, McLean CA, Morris CM, Seeley WW, Miller BL, Gaig C, Vonsattel JPG, White CL, Roeber S, Kretzschmar H, Troncoso JC, Troakes C, ... ... Lee VM, et al. C9orf72 intermediate repeats are associated with corticobasal degeneration, increased C9orf72 expression and disruption of autophagy. Acta Neuropathologica. PMID 31327044 DOI: 10.1007/S00401-019-02045-5  0.662
2019 Henderson MX, Trojanowski JQ, Lee VM. α-Synuclein Pathology in Parkinson's Disease and Related α-Synucleinopathies. Neuroscience Letters. 134316. PMID 31170426 DOI: 10.1016/J.Neulet.2019.134316  0.415
2019 Wu Q, Takano H, Riddle DM, Trojanowski JQ, Coulter DA, Lee VM. Alpha-synuclein (αSyn) preformed fibrils induce endogenous αSyn aggregation, compromise synaptic activity and enhance synapse loss in cultured excitatory hippocampal neurons. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. PMID 31036761 DOI: 10.1523/Jneurosci.0060-19.2019  0.583
2019 Berson A, Goodman LD, Sartoris AN, Otte CG, Aykit JA, Lee VM, Trojanowski JQ, Bonini NM. Drosophila Ref1/ALYREF regulates transcription and toxicity associated with ALS/FTD disease etiologies. Acta Neuropathologica Communications. 7: 65. PMID 31036086 DOI: 10.1186/S40478-019-0710-X  0.431
2019 Gibbons GS, Kim SJ, Robinson JL, Changolkar L, Irwin DJ, Shaw LM, Lee VM, Trojanowski JQ. Detection of Alzheimer's disease (AD) specific tau pathology with conformation-selective anti-tau monoclonal antibody in co-morbid frontotemporal lobar degeneration-tau (FTLD-tau). Acta Neuropathologica Communications. 7: 34. PMID 30832741 DOI: 10.1186/S40478-019-0687-5  0.458
2019 Zhang B, Kehm V, Gathagan R, Leight SN, Trojanowski JQ, Lee VM, Luk KC. Stereotaxic Targeting of Alpha-Synuclein Pathology in Mouse Brain Using Preformed Fibrils. Methods in Molecular Biology (Clifton, N.J.). 1948: 45-57. PMID 30771169 DOI: 10.1007/978-1-4939-9124-2_5  0.446
2019 Karpowicz RJ, Trojanowski JQ, Lee VM. Transmission of α-synuclein seeds in neurodegenerative disease: recent developments. Laboratory Investigation; a Journal of Technical Methods and Pathology. PMID 30760864 DOI: 10.1038/S41374-019-0195-Z  0.38
2019 Chung CY, Berson A, Kennerdell JR, Sartoris A, Unger T, Porta S, Kim HJ, Smith ER, Shilatifard A, Van Deerlin V, Lee VM, Chen-Plotkin A, Bonini NM. Author Correction: Aberrant activation of non-coding RNA targets of transcriptional elongation complexes contributes to TDP-43 toxicity. Nature Communications. 10: 555. PMID 30696825 DOI: 10.1038/S41467-019-08562-X  0.481
2018 Coughlin DG, Xie SX, Liang M, Williams A, Peterson C, Weintraub D, McMillan CT, Wolk DA, Akhtar RS, Hurtig H, Coslett HB, Hamilton R, Siderowf A, Duda JE, Rascovsky K, ... ... Lee VM, et al. Cognitive and Pathological Influences of Tau Pathology in Lewy Body Disorders. Annals of Neurology. PMID 30549331 DOI: 10.1002/Ana.25392  0.713
2018 Olsson B, Portelius E, Cullen NC, Sandelius Å, Zetterberg H, Andreasson U, Höglund K, Irwin DJ, Grossman M, Weintraub D, Chen-Plotkin A, Wolk D, McCluskey L, Elman L, Shaw LM, ... ... Lee VM, et al. Association of Cerebrospinal Fluid Neurofilament Light Protein Levels With Cognition in Patients With Dementia, Motor Neuron Disease, and Movement Disorders. Jama Neurology. PMID 30508027 DOI: 10.1001/Jamaneurol.2018.3746  0.726
2018 Spiller KJ, Khan T, Dominique MA, Restrepo CR, Cotton-Samuel D, Levitan M, Jafar-Nejad P, Zhang B, Soriano A, Rigo F, Trojanowski JQ, Lee VM. Reduction of matrix metalloproteinase 9 (MMP-9) protects motor neurons from TDP-43-triggered death in rNLS8 mice. Neurobiology of Disease. PMID 30458231 DOI: 10.1016/J.Nbd.2018.11.013  0.623
2018 Zhang B, Yao Y, Cornec AS, Oukoloff K, James MJ, Koivula P, Trojanowski JQ, Smith AB, Lee VM, Ballatore C, Brunden KR. A brain-penetrant triazolopyrimidine enhances microtubule-stability, reduces axonal dysfunction and decreases tau pathology in a mouse tauopathy model. Molecular Neurodegeneration. 13: 59. PMID 30404654 DOI: 10.1186/S13024-018-0291-3  0.45
2018 Chung CY, Berson A, Kennerdell JR, Sartoris A, Unger T, Porta S, Kim HJ, Smith ER, Shilatifard A, Van Deerlin V, Lee VM, Chen-Plotkin A, Bonini NM. Aberrant activation of non-coding RNA targets of transcriptional elongation complexes contributes to TDP-43 toxicity. Nature Communications. 9: 4406. PMID 30353006 DOI: 10.1038/S41467-018-06543-0  0.565
2018 Porta S, Xu Y, Restrepo CR, Kwong LK, Zhang B, Brown HJ, Lee EB, Trojanowski JQ, Lee VM. Patient-derived frontotemporal lobar degeneration brain extracts induce formation and spreading of TDP-43 pathology in vivo. Nature Communications. 9: 4220. PMID 30310141 DOI: 10.1038/S41467-018-06548-9  0.653
2018 Brettschneider J, Suh E, Robinson JL, Fang L, Lee EB, Irwin DJ, Grossman M, Van Deerlin VM, Lee VM, Trojanowski JQ. Converging Patterns of α-Synuclein Pathology in Multiple System Atrophy. Journal of Neuropathology and Experimental Neurology. PMID 30203094 DOI: 10.1093/Jnen/Nly080  0.677
2018 McGurk L, Mojsilovic-Petrovic J, Van Deerlin VM, Shorter J, Kalb RG, Lee VM, Trojanowski JQ, Lee EB, Bonini NM. Nuclear poly(ADP-ribose) activity is a therapeutic target in amyotrophic lateral sclerosis. Acta Neuropathologica Communications. 6: 84. PMID 30157956 DOI: 10.1186/S40478-018-0586-1  0.469
2018 Schmitz M, Villar-Piqué A, Llorens F, Gmitterová K, Hermann P, Varges D, Zafar S, Lingor P, Vanderstichele H, Demeyer L, Stoops E, Trojanowski JQ, Lee VM, Zerr I. Cerebrospinal Fluid Total and Phosphorylated α-Synuclein in Patients with Creutzfeldt-Jakob Disease and Synucleinopathy. Molecular Neurobiology. PMID 30136097 DOI: 10.1007/S12035-018-1313-4  0.437
2018 Deming Y, Dumitrescu L, Barnes LL, Thambisetty M, Kunkle B, Gifford KA, Bush WS, Chibnik LB, Mukherjee S, De Jager PL, Kukull W, Huentelman M, Crane PK, Resnick SM, Keene CD, ... ... Lee VM, et al. Sex-specific genetic predictors of Alzheimer's disease biomarkers. Acta Neuropathologica. PMID 29967939 DOI: 10.1007/s00401-018-1881-4  0.343
2018 Robinson JL, Corrada MM, Kovacs GG, Dominique M, Caswell C, Xie SX, Lee VM, Kawas CH, Trojanowski JQ. Non-Alzheimer's contributions to dementia and cognitive resilience in The 90+ Study. Acta Neuropathologica. PMID 29916037 DOI: 10.1007/S00401-018-1872-5  0.416
2018 Kovacs GG, Xie SX, Robinson JL, Lee EB, Smith DH, Schuck T, Lee VM, Trojanowski JQ. Sequential stages and distribution patterns of aging-related tau astrogliopathy (ARTAG) in the human brain. Acta Neuropathologica Communications. 6: 50. PMID 29891013 DOI: 10.1186/S40478-018-0552-Y  0.641
2018 Robinson JL, Lee EB, Xie SX, Rennert L, Suh E, Bredenberg C, Caswell C, Van Deerlin VM, Yan N, Yousef A, Hurtig HI, Siderowf A, Grossman M, McMillan CT, Miller B, ... ... Lee VM, et al. Neurodegenerative disease concomitant proteinopathies are prevalent, age-related and APOE4-associated. Brain : a Journal of Neurology. PMID 29878075 DOI: 10.1093/Brain/Awy146  0.79
2018 Peng C, Gathagan RJ, Covell DJ, Medellin C, Stieber A, Robinson JL, Zhang B, Pitkin RM, Olufemi MF, Luk KC, Trojanowski JQ, Lee VM. Cellular milieu imparts distinct pathological α-synuclein strains in α-synucleinopathies. Nature. PMID 29743672 DOI: 10.1038/S41586-018-0104-4  0.538
2018 Akhtar RS, Licata JP, Luk KC, Shaw LM, Trojanowski JQ, Lee VM. Measurements of auto-antibodies to α-synuclein in the serum and cerebral spinal fluids of patients with Parkinson's disease. Journal of Neurochemistry. PMID 29500813 DOI: 10.1111/Jnc.14330  0.355
2018 Spiller KJ, Restrepo CR, Khan T, Dominique MA, Fang TC, Canter RG, Roberts CJ, Miller KR, Ransohoff RM, Trojanowski JQ, Lee VM. Microglia-mediated recovery from ALS-relevant motor neuron degeneration in a mouse model of TDP-43 proteinopathy. Nature Neuroscience. PMID 29463850 DOI: 10.1038/S41593-018-0083-7  0.79
2018 Polinski NK, Volpicelli-Daley LA, Sortwell CE, Luk KC, Cremades N, Gottler LM, Froula J, Duffy MF, Lee VM, Martinez TN, Dave KD. Best Practices for Generating and Using Alpha-Synuclein Pre-Formed Fibrils to Model Parkinson's Disease in Rodents. Journal of Parkinson's Disease. PMID 29400668 DOI: 10.3233/Jpd-171248  0.656
2018 Dumitrescu L, Deming Y, Lu Q, Beecham GW, Kunkle BW, Del-Aguila JL, Fernandez MV, Budde JP, Fagan AM, Jager PLD, Albert MS, Moghekar A, Riemenschneider M, Petersen RC, Barnes LL, ... ... Lee VM, et al. P1-139: The Contribution Of Sex-Specific Associations In Genetic Studies Of Alzheimer'S Disease Pathology Alzheimers & Dementia. 14. DOI: 10.1016/J.Jalz.2018.06.142  0.484
2017 Rey NL, George S, Steiner JA, Madaj Z, Luk KC, Trojanowski JQ, Lee VM, Brundin P. Spread of aggregates after olfactory bulb injection of α-synuclein fibrils is associated with early neuronal loss and is reduced long term. Acta Neuropathologica. PMID 29209768 DOI: 10.1007/S00401-017-1792-9  0.385
2017 He Z, Guo JL, McBride JD, Narasimhan S, Kim H, Changolkar L, Zhang B, Gathagan RJ, Yue C, Dengler C, Stieber A, Nitla M, Coulter DA, Abel T, Brunden KR, ... ... Lee VM, et al. Amyloid-β plaques enhance Alzheimer's brain tau-seeded pathologies by facilitating neuritic plaque tau aggregation. Nature Medicine. PMID 29200205 DOI: 10.1038/Nm.4443  0.822
2017 Berson A, Sartoris A, Nativio R, Van Deerlin V, Toledo JB, Porta S, Liu S, Chung CY, Garcia BA, Lee VM, Trojanowski JQ, Johnson FB, Berger SL, Bonini NM. TDP-43 Promotes Neurodegeneration by Impairing Chromatin Remodeling. Current Biology : Cb. PMID 29153328 DOI: 10.1016/J.Cub.2017.10.024  0.344
2017 Banks RA, Gibbons GS, Kim B, Xu H, Changolkar L, Leight SN, Riddle DM, Li C, Gathagan RJ, Brown HJ, Zhang B, Trojanowski JQ, Lee VM. GFP-mutant human tau transgenic mice develop tauopathy following CNS injections of Alzheimer's brain-derived pathological tau or synthetic mutant human tau fibrils. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. PMID 28986461 DOI: 10.1523/Jneurosci.2393-17.2017  0.5
2017 Wang J, Han X, Leu NA, Sterling S, Kurosaka S, Fina M, Lee VM, Dong DW, Yates JR, Kashina A. Protein arginylation targets alpha synuclein, facilitates normal brain health, and prevents neurodegeneration. Scientific Reports. 7: 11323. PMID 28900170 DOI: 10.1038/S41598-017-11713-Z  0.368
2017 Yousef A, Robinson JL, Irwin DJ, Byrne MD, Kwong LK, Lee EB, Xu Y, Xie SX, Rennert L, Suh E, Van Deerlin VM, Grossman M, Lee VM, Trojanowski JQ. Neuron loss and degeneration in the progression of TDP-43 in frontotemporal lobar degeneration. Acta Neuropathologica Communications. 5: 68. PMID 28877758 DOI: 10.1186/S40478-017-0471-3  0.679
2017 Kovacs GG, Lee VM, Trojanowski JQ. Protein astrogliopathies in human neurodegenerative diseases and aging. Brain Pathology (Zurich, Switzerland). 27: 675-690. PMID 28805003 DOI: 10.1111/Bpa.12536  0.575
2017 Kovacs GG, Yousef A, Kaindl S, Lee VM, Trojanowski JQ. Connexin-43 and Aquaporin-4 are markers of ARTAG-related astroglial response. Neuropathology and Applied Neurobiology. PMID 28755467 DOI: 10.1111/Nan.12427  0.416
2017 Peng C, Gathagan RJ, Lee VM. Distinct α-Synuclein strains and implications for heterogeneity among α-Synucleinopathies. Neurobiology of Disease. PMID 28751258 DOI: 10.1016/j.nbd.2017.07.018  0.475
2017 Paolicelli RC, Jawaid A, Henstridge CM, Valeri A, Merlini M, Robinson JL, Lee EB, Rose J, Appel S, Lee VM, Trojanowski JQ, Spires-Jones T, Schulz PE, Rajendran L. TDP-43 Depletion in Microglia Promotes Amyloid Clearance but Also Induces Synapse Loss. Neuron. PMID 28669544 DOI: 10.1016/J.Neuron.2017.05.037  0.672
2017 Tapias V, Hu X, Luk KC, Sanders LH, Lee VM, Timothy Greenamyre J. Synthetic alpha-synuclein fibrils cause mitochondrial impairment and selective dopamine neurodegeneration in part via iNOS-mediated nitric oxide production. Cellular and Molecular Life Sciences : Cmls. PMID 28534083 DOI: 10.1007/S00018-017-2541-X  0.378
2017 Cornec AS, Monti L, Kovalevich J, Makani V, James MJ, Vijayendran KG, Oukoloff K, Yao Y, Lee VM, Trojanowski JQ, Smith Iii AB, Brunden KR, Ballatore C. Multi-targeted Imidazoles: Potential Therapeutic Leads for Alzheimer's and Other Neurodegenerative Diseases. Journal of Medicinal Chemistry. PMID 28530811 DOI: 10.1021/Acs.Jmedchem.7B00475  0.441
2017 Kovacs GG, Robinson JL, Xie SX, Lee EB, Grossman M, Wolk DA, Irwin DJ, Weintraub D, Kim CF, Schuck T, Yousef A, Wagner ST, Suh E, Van Deerlin VM, Lee VM, et al. Evaluating the Patterns of Aging-Related Tau Astrogliopathy Unravels Novel Insights Into Brain Aging and Neurodegenerative Diseases. Journal of Neuropathology and Experimental Neurology. PMID 28340083 DOI: 10.1093/Jnen/Nlx007  0.712
2017 Deming Y, Li Z, Kapoor M, Harari O, Del-Aguila JL, Black K, Carrell D, Cai Y, Fernandez MV, Budde J, Ma S, Saef B, Howells B, Huang KL, Bertelsen S, ... ... Lee VM, et al. Genome-wide association study identifies four novel loci associated with Alzheimer's endophenotypes and disease modifiers. Acta Neuropathologica. PMID 28247064 DOI: 10.1007/s00401-017-1685-y  0.397
2017 Lee EB, Porta S, Michael Baer G, Xu Y, Suh E, Kwong LK, Elman L, Grossman M, Lee VM, Irwin DJ, Van Deerlin VM, Trojanowski JQ. Expansion of the classification of FTLD-TDP: distinct pathology associated with rapidly progressive frontotemporal degeneration. Acta Neuropathologica. PMID 28130640 DOI: 10.1007/S00401-017-1679-9  0.702
2017 Ballatore C, Brunden KR, Trojanowski JQ, Lee VM, Smith AB. Non-Naturally Occurring Small Molecule Microtubule-Stabilizing Agents: A Potential Tactic for CNS-Directed Therapies. Acs Chemical Neuroscience. 8: 5-7. PMID 28095679 DOI: 10.1021/Acschemneuro.6B00384  0.371
2017 Ono M, Sahara N, Kumata K, Ji B, Ni R, Koga S, Dickson DW, Trojanowski JQ, Lee VM, Yoshida M, Hozumi I, Yoshiyama Y, van Swieten JC, Nordberg A, Suhara T, et al. Distinct binding of PET ligands PBB3 and AV-1451 to tau fibril strains in neurodegenerative tauopathies. Brain : a Journal of Neurology. PMID 28087578 DOI: 10.1093/Brain/Aww339  0.441
2017 Lee VM. Cell-To-Cell Transmission Of Pathological Tau: A Potential Mechanism Of Disease Progression In Alzheimer'S And Other Tauopathies Alzheimers & Dementia. 13: 1224. DOI: 10.1016/J.Jalz.2017.07.415  0.408
2016 Kovacs GG, Kwong LK, Grossman M, Irwin DJ, Lee EB, Robinson JL, Suh E, Van Deerlin VM, Lee VM, Trojanowski JQ. Tauopathy with hippocampal 4-repeat tau immunoreactive spherical inclusions: a report of three cases. Brain Pathology (Zurich, Switzerland). PMID 28019685 DOI: 10.1111/Bpa.12482  0.731
2016 Brunden KR, Lee VM, Smith AB, Trojanowski JQ, Ballatore C. Altered microtubule dynamics in neurodegenerative disease: Therapeutic potential of microtubule-stabilizing drugs. Neurobiology of Disease. PMID 28012891 DOI: 10.1016/J.Nbd.2016.12.021  0.478
2016 Chapuis J, Flaig A, Grenier-Boley B, Eysert F, Pottiez V, Deloison G, Vandeputte A, Ayral AM, Mendes T, Desai S, Goate AM, Kauwe JS, Leroux F, Herledan A, Demiautte F, ... ... Lee VM, et al. Genome-wide, high-content siRNA screening identifies the Alzheimer's genetic risk factor FERMT2 as a major modulator of APP metabolism. Acta Neuropathologica. PMID 27933404 DOI: 10.1007/S00401-016-1652-Z  0.373
2016 McMillan CT, Irwin DJ, Nasrallah I, Phillips JS, Spindler M, Rascovsky K, Ternes K, Jester C, Wolk DA, Kwong LK, Lee VM, Lee EB, Trojanowski JQ, Grossman M. Multimodal evaluation demonstrates in vivo (18)F-AV-1451 uptake in autopsy-confirmed corticobasal degeneration. Acta Neuropathologica. PMID 27815633 DOI: 10.1007/S00401-016-1640-3  0.61
2016 Guo JL, Narasimhan S, Changolkar L, He Z, Stieber A, Zhang B, Gathagan RJ, Iba M, McBride JD, Trojanowski JQ, Lee VM. Unique pathological tau conformers from Alzheimer's brains transmit tau pathology in nontransgenic mice. The Journal of Experimental Medicine. PMID 27810929 DOI: 10.1084/Jem.20160833  0.833
2016 Khanna MR, Kovalevich J, Lee VM, Trojanowski JQ, Brunden KR. Therapeutic strategies for the treatment of tauopathies: Hopes and challenges. Alzheimer's & Dementia : the Journal of the Alzheimer's Association. 12: 1051-1065. PMID 27751442 DOI: 10.1016/J.Jalz.2016.06.006  0.506
2016 Imamura K, Sahara N, Kanaan NM, Tsukita K, Kondo T, Kutoku Y, Ohsawa Y, Sunada Y, Kawakami K, Hotta A, Yawata S, Watanabe D, Hasegawa M, Trojanowski JQ, Lee VM, et al. Calcium dysregulation contributes to neurodegeneration in FTLD patient iPSC-derived neurons. Scientific Reports. 6: 34904. PMID 27721502 DOI: 10.1038/Srep34904  0.429
2016 Makani V, Zhang B, Han H, Yao Y, Lassalas P, Lou K, Paterson I, Lee VM, Trojanowski JQ, Ballatore C, Smith AB, Brunden KR. Evaluation of the brain-penetrant microtubule-stabilizing agent, dictyostatin, in the PS19 tau transgenic mouse model of tauopathy. Acta Neuropathologica Communications. 4: 106. PMID 27687527 DOI: 10.1186/S40478-016-0378-4  0.422
2016 Spiller KJ, Restrepo CR, Khan T, Stieber AM, Kwong LK, Trojanowski JQ, Lee VM. Progression of motor neuron disease is accelerated and the ability to recover is compromised with advanced age in rNLS8 mice. Acta Neuropathologica Communications. 4: 105. PMID 27687289 DOI: 10.1186/S40478-016-0377-5  0.646
2016 Placek K, Massimo L, Olm C, Ternes K, Firn K, Van Deerlin V, Lee EB, Trojanowski JQ, Lee VM, Irwin D, Grossman M, McMillan CT. Cognitive reserve in frontotemporal degeneration: Neuroanatomic and neuropsychological evidence. Neurology. PMID 27683847 DOI: 10.1212/WNL.0000000000003250  0.65
2016 Luk KC, Covell DJ, Kehm VM, Zhang B, Song IY, Byrne MD, Pitkin RM, Decker SC, Trojanowski JQ, Lee VM. Molecular and Biological Compatibility with Host Alpha-Synuclein Influences Fibril Pathogenicity. Cell Reports. 16: 3373-87. PMID 27653697 DOI: 10.1016/J.Celrep.2016.08.053  0.362
2016 Rey NL, Steiner JA, Maroof N, Luk KC, Madaj Z, Trojanowski JQ, Lee VM, Brundin P. Widespread transneuronal propagation of α-synucleinopathy triggered in olfactory bulb mimics prodromal Parkinson's disease. The Journal of Experimental Medicine. PMID 27503075 DOI: 10.1084/Jem.20160368  0.372
2016 Spiller KJ, Cheung CJ, Restrepo CR, Kwong LK, Stieber AM, Trojanowski JQ, Lee VM. Selective Motor Neuron Resistance and Recovery in a New Inducible Mouse Model of TDP-43 Proteinopathy. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 36: 7707-17. PMID 27445147 DOI: 10.1523/Jneurosci.1457-16.2016  0.65
2016 Lee S, Shang Y, Redmond SA, Urisman A, Tang AA, Li KH, Burlingame AL, Pak RA, Jovičić A, Gitler AD, Wang J, Gray NS, Seeley WW, Siddique T, Bigio EH, ... Lee VM, et al. Activation of HIPK2 Promotes ER Stress-Mediated Neurodegeneration in Amyotrophic Lateral Sclerosis. Neuron. PMID 27321923 DOI: 10.1016/J.Neuron.2016.05.021  0.37
2016 Guo JL, Buist A, Soares A, Callaerts K, Calafate S, Stevenaert F, Daniels JP, Zoll BE, Crowe A, Brunden KR, Moechars D, Lee VM. The Dynamics and Turnover of Tau Aggregates in Cultured Cells: Insights into Therapies for Tauopathies. The Journal of Biological Chemistry. PMID 27129267 DOI: 10.1074/jbc.M115.712083  0.452
2016 Kovalevich J, Cornec AS, Yao Y, James M, Crowe A, Lee VM, Trojanowski JQ, Smith AB, Ballatore C, Brunden KR. Characterization of brain-penetrant pyrimidine-containing molecules with differential microtubule-stabilizing activities developed as potential therapeutic agents for Alzheimer's disease and related tauopathies. The Journal of Pharmacology and Experimental Therapeutics. PMID 26980057 DOI: 10.1124/Jpet.115.231175  0.426
2016 Lee V. Transmission of Misfolded Proteins in Neurodegenerative Disorders: A Common Mechanism of Disease Progression Neurobiology of Aging. 39. DOI: 10.1016/J.Neurobiolaging.2016.01.044  0.351
2016 Deming Y, Harari O, Black K, Carrell D, Cai Y, Del-Aguila JL, Fernandez V, Budde J, Ma S, Saef B, Bertelsen S, Kauwe J, Fagan AM, Holtzman DM, Morris JC, ... ... Lee VM, et al. Cerebrospinal Fluid Levels Of Amyloid Beta And Tau As Endophenotypes Reveal Novel Variants Potentially Informative For Alzheimer'S Disease Alzheimers & Dementia. 12: 252. DOI: 10.1016/J.Jalz.2016.06.452  0.5
2016 Shinotoh H, Sahara N, Shimada H, Ikeuchi T, Shunske K, Strogonsky AJ, Nishioka K, Hanyu H, Swieten JCv, Ono M, Kimura Y, Hirano S, Ishii K, Zhang M, Trojanowski JQ, ... Lee VM, et al. [11C]Pbb3 Pet Visualizes Tau Aggregates In Patients With Ftdp-17 Mapt Gene Mutation Alzheimers & Dementia. 12. DOI: 10.1016/J.Jalz.2016.06.217  0.424
2016 Stoops E, Majbour N, Mauroo K, Demeyer L, Lashuel H, Trojanowski JQ, Lee VM, Agnaf OE, Vanderstichele HM. Performance Evaluation Of New Absorbance-Based Elisas For Measuring Different Alpha-Synuclein (A-Syn) Species In Csf And Plasma Alzheimers & Dementia. 12. DOI: 10.1016/J.Jalz.2016.06.1330  0.398
2015 Toledo JB, Gopal P, Raible K, Irwin DJ, Brettschneider J, Sedor S, Waits K, Boluda S, Grossman M, Van Deerlin VM, Lee EB, Arnold SE, Duda JE, Hurtig H, Lee VM, et al. Pathological α-synuclein distribution in subjects with coincident Alzheimer's and Lewy body pathology. Acta Neuropathologica. PMID 26721587 DOI: 10.1007/S00401-015-1526-9  0.692
2015 Leung YY, Toledo JB, Nefedov A, Polikar R, Raghavan N, Xie SX, Farnum M, Schultz T, Baek Y, Deerlin VV, Hu WT, Holtzman DM, Fagan AM, Perrin RJ, Grossman M, ... ... Lee VM, et al. Identifying amyloid pathology-related cerebrospinal fluid biomarkers for Alzheimer's disease in a multicohort study. Alzheimer's & Dementia (Amsterdam, Netherlands). 1: 339-348. PMID 26693175 DOI: 10.1016/J.Dadm.2015.06.008  0.707
2015 Irwin DJ, Brettschneider J, McMillan CT, Cooper F, Olm C, Arnold SE, Van Deerlin VM, Seeley WW, Miller BL, Lee EB, Lee VM, Grossman M, Trojanowski JQ. Deep Clinical and Neuropathological Phenotyping of Pick's Disease. Annals of Neurology. PMID 26583316 DOI: 10.1002/Ana.24559  0.667
2015 Irwin DJ, Byrne MD, McMillan CT, Cooper F, Arnold SE, Lee EB, Van Deerlin VM, Xie SX, Lee VM, Grossman M, Trojanowski JQ. Semi-Automated Digital Image Analysis of Pick's Disease and TDP-3 Proteinopathy. The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society. PMID 26538548 DOI: 10.1369/0022155415614303  0.671
2015 Amlie-Wolf A, Ryvkin P, Tong R, Dragomir I, Suh E, Xu Y, Van Deerlin VM, Gregory BD, Kwong LK, Trojanowski JQ, Lee VM, Wang LS, Lee EB. Transcriptomic Changes Due to Cytoplasmic TDP-43 Expression Reveal Dysregulation of Histone Transcripts and Nuclear Chromatin. Plos One. 10: e0141836. PMID 26510133 DOI: 10.1371/Journal.Pone.0141836  0.602
2015 Walker AK, Tripathy K, Restrepo CR, Ge G, Xu Y, Kwong LK, Trojanowski JQ, Lee VM. An insoluble frontotemporal lobar degeneration-associated TDP-43 C-terminal fragment causes neurodegeneration and hippocampus pathology in transgenic mice. Human Molecular Genetics. PMID 26476406 DOI: 10.1093/Hmg/Ddv424  0.451
2015 Walker AK, Spiller KJ, Ge G, Zheng A, Xu Y, Zhou M, Tripathy K, Kwong LK, Trojanowski JQ, Lee VM. Functional recovery in new mouse models of ALS/FTLD after clearance of pathological cytoplasmic TDP-43. Acta Neuropathologica. PMID 26197969 DOI: 10.1007/S00401-015-1460-X  0.665
2015 Iba M, McBride JD, Guo JL, Zhang B, Trojanowski JQ, Lee VM. Tau pathology spread in PS19 tau transgenic mice following locus coeruleus (LC) injections of synthetic tau fibrils is determined by the LC's afferent and efferent connections. Acta Neuropathologica. PMID 26150341 DOI: 10.1007/S00401-015-1458-4  0.563
2015 Robinson JL, Suh E, Wood EM, Lee EB, Coslett HB, Raible K, Lee VM, Trojanowski JQ, Van Deerlin VM. Common neuropathological features underlie distinct clinical presentations in three siblings with hereditary diffuse leukoencephalopathy with spheroids caused by CSF1R p.Arg782His. Acta Neuropathologica Communications. 3: 42. PMID 26141825 DOI: 10.1186/S40478-015-0219-X  0.594
2015 Paumier KL, Luk KC, Manfredsson FP, Kanaan NM, Lipton JW, Collier TJ, Steece-Collier K, Kemp CJ, Celano S, Schulz E, Sandoval IM, Fleming S, Dirr E, Polinski NK, Trojanowski JQ, ... Lee VM, et al. Intrastriatal injection of pre-formed mouse α-synuclein fibrils into rats triggers α-synuclein pathology and bilateral nigrostriatal degeneration. Neurobiology of Disease. 82: 185-199. PMID 26093169 DOI: 10.1016/J.Nbd.2015.06.003  0.441
2015 Kouri N, Ross OA, Dombroski B, Younkin CS, Serie DJ, Soto-Ortolaza A, Baker M, Finch NC, Yoon H, Kim J, Fujioka S, McLean CA, Ghetti B, Spina S, Cantwell LB, ... ... Lee VM, et al. Genome-wide association study of corticobasal degeneration identifies risk variants shared with progressive supranuclear palsy. Nature Communications. 6: 7247. PMID 26077951 DOI: 10.1038/Ncomms8247  0.653
2015 Wheeler JM, McMillan PJ, Hawk M, Iba M, Robinson L, Xu GJ, Dombroski BA, Jeong D, Dichter MA, Juul H, Loomis E, Raskind M, Leverenz JB, Trojanowski JQ, Lee VM, et al. High copy wildtype human 1N4R tau expression promotes early pathological tauopathy accompanied by cognitive deficits without progressive neurofibrillary degeneration. Acta Neuropathologica Communications. 3: 33. PMID 26041339 DOI: 10.1186/S40478-015-0210-6  0.487
2015 Sankaranarayanan S, Barten DM, Vana L, Devidze N, Yang L, Cadelina G, Hoque N, DeCarr L, Keenan S, Lin A, Cao Y, Snyder B, Zhang B, Nitla M, Hirschfeld G, ... ... Lee VM, et al. Passive immunization with phospho-tau antibodies reduces tau pathology and functional deficits in two distinct mouse tauopathy models. Plos One. 10: e0125614. PMID 25933020 DOI: 10.1371/Journal.Pone.0125614  0.488
2015 Brettschneider J, Del Tredici K, Irwin DJ, Grossman M, Robinson JL, Toledo JB, Lee EB, Fang L, Van Deerlin VM, Ludolph AC, Lee VM, Braak H, Trojanowski JQ. Erratum to: Sequential distribution of pTDP-43 pathology in behavioral variant frontotemporal dementia (bvFTD). Acta Neuropathologica. 129: 929. PMID 25931052 DOI: 10.1007/S00401-015-1428-X  0.653
2015 Mitsui J, Matsukawa T, Sasaki H, Yabe I, Matsushima M, Dürr A, Brice A, Takashima H, Kikuchi A, Aoki M, Ishiura H, Yasuda T, Date H, Ahsan B, Iwata A, ... ... Lee VM, et al. Variants associated with Gaucher disease in multiple system atrophy. Annals of Clinical and Translational Neurology. 2: 417-26. PMID 25909086 DOI: 10.1002/Acn3.185  0.361
2015 Goossens J, Vanmechelen E, Trojanowski JQ, Lee VM, Van Broeckhoven C, van der Zee J, Engelborghs S. TDP-43 as a possible biomarker for frontotemporal lobar degeneration: a systematic review of existing antibodies. Acta Neuropathologica Communications. 3: 15. PMID 25853864 DOI: 10.1186/S40478-015-0195-1  0.339
2015 Cornec AS, James MJ, Kovalevich J, Trojanowski JQ, Lee VM, Smith AB, Ballatore C, Brunden KR. Pharmacokinetic, pharmacodynamic and metabolic characterization of a brain retentive microtubule (MT)-stabilizing triazolopyrimidine. Bioorganic & Medicinal Chemistry Letters. PMID 25819095 DOI: 10.1016/J.Bmcl.2015.03.002  0.328
2015 Porta S, Kwong LK, Trojanowski JQ, Lee VM. Drosha inclusions are new components of dipeptide-repeat protein aggregates in FTLD-TDP and ALS C9orf72 expansion cases. Journal of Neuropathology and Experimental Neurology. 74: 380-7. PMID 25756586 DOI: 10.1097/Nen.0000000000000182  0.41
2015 Brettschneider J, Del Tredici K, Lee VM, Trojanowski JQ. Spreading of pathology in neurodegenerative diseases: a focus on human studies. Nature Reviews. Neuroscience. 16: 109-20. PMID 25588378 DOI: 10.1038/Nrn3887  0.436
2015 Cohen TJ, Hwang AW, Restrepo CR, Yuan CX, Trojanowski JQ, Lee VM. An acetylation switch controls TDP-43 function and aggregation propensity. Nature Communications. 6: 5845. PMID 25556531 DOI: 10.1038/Ncomms6845  0.374
2015 Irwin DJ, Cairns NJ, Grossman M, McMillan CT, Lee EB, Van Deerlin VM, Lee VM, Trojanowski JQ. Frontotemporal lobar degeneration: defining phenotypic diversity through personalized medicine. Acta Neuropathologica. 129: 469-91. PMID 25549971 DOI: 10.1007/S00401-014-1380-1  0.702
2015 Boluda S, Iba M, Zhang B, Raible KM, Lee VM, Trojanowski JQ. Differential induction and spread of tau pathology in young PS19 tau transgenic mice following intracerebral injections of pathological tau from Alzheimer's disease or corticobasal degeneration brains. Acta Neuropathologica. 129: 221-37. PMID 25534024 DOI: 10.1007/S00401-014-1373-0  0.557
2015 Peeraer E, Bottelbergs A, Van Kolen K, Stancu IC, Vasconcelos B, Mahieu M, Duytschaever H, Ver Donck L, Torremans A, Sluydts E, Van Acker N, Kemp JA, Mercken M, Brunden KR, Trojanowski JQ, ... ... Lee VM, et al. Intracerebral injection of preformed synthetic tau fibrils initiates widespread tauopathy and neuronal loss in the brains of tau transgenic mice. Neurobiology of Disease. 73: 83-95. PMID 25220759 DOI: 10.1016/J.Jalz.2014.04.339  0.568
2014 Volpicelli-Daley LA, Gamble KL, Schultheiss CE, Riddle DM, West AB, Lee VM. Formation of α-synuclein Lewy neurite-like aggregates in axons impedes the transport of distinct endosomes. Molecular Biology of the Cell. 25: 4010-23. PMID 25298402 DOI: 10.1091/Mbc.E14-02-0741  0.657
2014 Volpicelli-Daley LA, Luk KC, Lee VM. Addition of exogenous α-synuclein preformed fibrils to primary neuronal cultures to seed recruitment of endogenous α-synuclein to Lewy body and Lewy neurite-like aggregates. Nature Protocols. 9: 2135-46. PMID 25122523 DOI: 10.1038/Nprot.2014.143  0.668
2014 McGurk L, Lee VM, Trojanowksi JQ, Van Deerlin VM, Lee EB, Bonini NM. Poly-A binding protein-1 localization to a subset of TDP-43 inclusions in amyotrophic lateral sclerosis occurs more frequently in patients harboring an expansion in C9orf72. Journal of Neuropathology and Experimental Neurology. 73: 837-45. PMID 25111021 DOI: 10.1097/Nen.0000000000000102  0.605
2014 Yarchoan M, Toledo JB, Lee EB, Arvanitakis Z, Kazi H, Han LY, Louneva N, Lee VM, Kim SF, Trojanowski JQ, Arnold SE. Abnormal serine phosphorylation of insulin receptor substrate 1 is associated with tau pathology in Alzheimer's disease and tauopathies. Acta Neuropathologica. 128: 679-89. PMID 25107476 DOI: 10.1007/S00401-014-1328-5  0.67
2014 Polito VA, Li H, Martini-Stoica H, Wang B, Yang L, Xu Y, Swartzlander DB, Palmieri M, di Ronza A, Lee VM, Sardiello M, Ballabio A, Zheng H. Selective clearance of aberrant tau proteins and rescue of neurotoxicity by transcription factor EB. Embo Molecular Medicine. 6: 1142-60. PMID 25069841 DOI: 10.15252/Emmm.201303671  0.339
2014 Robinson JL, Molina-Porcel L, Corrada MM, Raible K, Lee EB, Lee VM, Kawas CH, Trojanowski JQ. Perforant path synaptic loss correlates with cognitive impairment and Alzheimer's disease in the oldest-old. Brain : a Journal of Neurology. 137: 2578-87. PMID 25012223 DOI: 10.1093/Brain/Awu190  0.616
2014 Irwin DJ, McMillan CT, Suh E, Powers J, Rascovsky K, Wood EM, Toledo JB, Arnold SE, Lee VM, Van Deerlin VM, Trojanowski JQ, Grossman M. Myelin oligodendrocyte basic protein and prognosis in behavioral-variant frontotemporal dementia. Neurology. 83: 502-9. PMID 24994843 DOI: 10.1212/Wnl.0000000000000668  0.477
2014 Lou K, Yao Y, Hoye AT, James MJ, Cornec AS, Hyde E, Gay B, Lee VM, Trojanowski JQ, Smith AB, Brunden KR, Ballatore C. Brain-penetrant, orally bioavailable microtubule-stabilizing small molecules are potential candidate therapeutics for Alzheimer's disease and related tauopathies. Journal of Medicinal Chemistry. 57: 6116-27. PMID 24992153 DOI: 10.1021/Jm5005623  0.382
2014 Tran HT, Chung CH, Iba M, Zhang B, Trojanowski JQ, Luk KC, Lee VM. Α-synuclein immunotherapy blocks uptake and templated propagation of misfolded α-synuclein and neurodegeneration. Cell Reports. 7: 2054-65. PMID 24931606 DOI: 10.1016/J.Celrep.2014.05.033  0.45
2014 Boluda S, Toledo JB, Irwin DJ, Raible KM, Byrne MD, Lee EB, Lee VM, Trojanowski JQ. A comparison of Aβ amyloid pathology staging systems and correlation with clinical diagnosis. Acta Neuropathologica. 128: 543-50. PMID 24916271 DOI: 10.1007/S00401-014-1308-9  0.644
2014 Brettschneider J, Arai K, Del Tredici K, Toledo JB, Robinson JL, Lee EB, Kuwabara S, Shibuya K, Irwin DJ, Fang L, Van Deerlin VM, Elman L, McCluskey L, Ludolph AC, Lee VM, et al. TDP-43 pathology and neuronal loss in amyotrophic lateral sclerosis spinal cord. Acta Neuropathologica. 128: 423-37. PMID 24916269 DOI: 10.1007/S00401-014-1299-6  0.62
2014 McCluskey LF, Geser F, Elman LB, Van Deerlin VM, Robinson JL, Lee VM, Trojanowski JQ. Atypical Alzheimer's disease in an elderly United States resident with amyotrophic lateral sclerosis and pathological tau in spinal motor neurons. Amyotrophic Lateral Sclerosis & Frontotemporal Degeneration. 15: 466-72. PMID 24809433 DOI: 10.3109/21678421.2014.903973  0.497
2014 Walker AK, Daniels CM, Goldman JE, Trojanowski JQ, Lee VM, Messing A. Astrocytic TDP-43 pathology in Alexander disease. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 34: 6448-58. PMID 24806671 DOI: 10.1523/Jneurosci.0248-14.2014  0.453
2014 Kwong LK, Irwin DJ, Walker AK, Xu Y, Riddle DM, Trojanowski JQ, Lee VM. Novel monoclonal antibodies to normal and pathologically altered human TDP-43 proteins. Acta Neuropathologica Communications. 2: 33. PMID 24690345 DOI: 10.1186/2051-5960-2-33  0.395
2014 Nuytemans K, Inchausti V, Beecham GW, Wang L, Dickson DW, Trojanowski JQ, Lee VM, Mash DC, Frosch MP, Foroud TM, Honig LS, Montine TJ, Dawson TM, Martin ER, Scott WK, et al. Absence of C9ORF72 expanded or intermediate repeats in autopsy-confirmed Parkinson's disease. Movement Disorders : Official Journal of the Movement Disorder Society. 29: 827-30. PMID 24573903 DOI: 10.1002/Mds.25838  0.372
2014 Guo JL, Lee VM. Cell-to-cell transmission of pathogenic proteins in neurodegenerative diseases. Nature Medicine. 20: 130-8. PMID 24504409 DOI: 10.1038/nm.3457  0.429
2014 Grossman M, Elman L, McCluskey L, McMillan CT, Boller A, Powers J, Rascovsky K, Hu W, Shaw L, Irwin DJ, Lee VM, Trojanowski JQ. Phosphorylated tau as a candidate biomarker for amyotrophic lateral sclerosis. Jama Neurology. 71: 442-8. PMID 24492862 DOI: 10.1001/Jamaneurol.2013.6064  0.632
2014 Gallagher MD, Suh E, Grossman M, Elman L, McCluskey L, Van Swieten JC, Al-Sarraj S, Neumann M, Gelpi E, Ghetti B, Rohrer JD, Halliday G, Van Broeckhoven C, Seilhean D, Shaw PJ, ... ... Lee VM, et al. TMEM106B is a genetic modifier of frontotemporal lobar degeneration with C9orf72 hexanucleotide repeat expansions. Acta Neuropathologica. 127: 407-18. PMID 24442578 DOI: 10.1007/S00401-013-1239-X  0.749
2014 Brunden KR, Trojanowski JQ, Smith AB, Lee VM, Ballatore C. Microtubule-stabilizing agents as potential therapeutics for neurodegenerative disease. Bioorganic & Medicinal Chemistry. 22: 5040-9. PMID 24433963 DOI: 10.1016/J.Bmc.2013.12.046  0.421
2014 Brettschneider J, Del Tredici K, Irwin DJ, Grossman M, Robinson JL, Toledo JB, Lee EB, Fang L, Van Deerlin VM, Ludolph AC, Lee VM, Braak H, Trojanowski JQ. Sequential distribution of pTDP-43 pathology in behavioral variant frontotemporal dementia (bvFTD). Acta Neuropathologica. 127: 423-39. PMID 24407427 DOI: 10.1007/S00401-013-1238-Y  0.672
2014 Ballatore C, Smith AB, Lee VM, Trojanowski JQ, Brunden KR. Aminothienopyridazines as imaging probes of tau pathology: a patent evaluation of WO2013090497. Expert Opinion On Therapeutic Patents. 24: 355-60. PMID 24387030 DOI: 10.1517/13543776.2014.871526  0.378
2014 McMillan CT, Toledo JB, Avants BB, Cook PA, Wood EM, Suh E, Irwin DJ, Powers J, Olm C, Elman L, McCluskey L, Schellenberg GD, Lee VM, Trojanowski JQ, Van Deerlin VM, et al. Genetic and neuroanatomic associations in sporadic frontotemporal lobar degeneration. Neurobiology of Aging. 35: 1473-82. PMID 24373676 DOI: 10.1016/J.Neurobiolaging.2013.11.029  0.487
2014 Kim HJ, Raphael AR, LaDow ES, McGurk L, Weber RA, Trojanowski JQ, Lee VM, Finkbeiner S, Gitler AD, Bonini NM. Therapeutic modulation of eIF2α phosphorylation rescues TDP-43 toxicity in amyotrophic lateral sclerosis disease models. Nature Genetics. 46: 152-60. PMID 24336168 DOI: 10.1038/Ng.2853  0.466
2014 Luk KC, Lee VM. Modeling Lewy pathology propagation in Parkinson's disease. Parkinsonism & Related Disorders. 20: S85-7. PMID 24262196 DOI: 10.1016/S1353-8020(13)70022-1  0.3
2014 Toledo JB, Van Deerlin VM, Lee EB, Suh E, Baek Y, Robinson JL, Xie SX, McBride J, Wood EM, Schuck T, Irwin DJ, Gross RG, Hurtig H, McCluskey L, Elman L, ... ... Lee VM, et al. A platform for discovery: The University of Pennsylvania Integrated Neurodegenerative Disease Biobank. Alzheimer's & Dementia : the Journal of the Alzheimer's Association. 10: 477-84.e1. PMID 23978324 DOI: 10.1016/J.Jalz.2013.06.003  0.758
2013 Brunden KR, Gardner NM, James MJ, Yao Y, Trojanowski JQ, Lee VM, Paterson I, Ballatore C, Smith AB. MT-Stabilizer, Dictyostatin, Exhibits Prolonged Brain Retention and Activity: Potential Therapeutic Implications. Acs Medicinal Chemistry Letters. 4: 886-9. PMID 24900764 DOI: 10.1021/Ml400233E  0.411
2013 Busch JI, Martinez-Lage M, Ashbridge E, Grossman M, Van Deerlin VM, Hu F, Lee VM, Trojanowski JQ, Chen-Plotkin AS. Expression of TMEM106B, the frontotemporal lobar degeneration-associated protein, in normal and diseased human brain. Acta Neuropathologica Communications. 1: 36. PMID 24252750 DOI: 10.1186/2051-5960-1-36  0.81
2013 Stutzbach LD, Xie SX, Naj AC, Albin R, Gilman S, Lee VM, Trojanowski JQ, Devlin B, Schellenberg GD. The unfolded protein response is activated in disease-affected brain regions in progressive supranuclear palsy and Alzheimer's disease. Acta Neuropathologica Communications. 1: 31. PMID 24252572 DOI: 10.1186/2051-5960-1-31  0.457
2013 Braak H, Brettschneider J, Ludolph AC, Lee VM, Trojanowski JQ, Del Tredici K. Amyotrophic lateral sclerosis--a model of corticofugal axonal spread. Nature Reviews. Neurology. 9: 708-14. PMID 24217521 DOI: 10.1038/Nrneurol.2013.221  0.471
2013 Maruyama M, Shimada H, Suhara T, Shinotoh H, Ji B, Maeda J, Zhang MR, Trojanowski JQ, Lee VM, Ono M, Masamoto K, Takano H, Sahara N, Iwata N, Okamura N, et al. Imaging of tau pathology in a tauopathy mouse model and in Alzheimer patients compared to normal controls. Neuron. 79: 1094-108. PMID 24050400 DOI: 10.1016/J.Neuron.2013.07.037  0.429
2013 Yarchoan M, Louneva N, Xie SX, Swenson FJ, Hu W, Soares H, Trojanowski JQ, Lee VM, Kling MA, Shaw LM, Chen-Plotkin A, Wolk DA, Arnold SE. Association of plasma C-reactive protein levels with the diagnosis of Alzheimer's disease. Journal of the Neurological Sciences. 333: 9-12. PMID 23978419 DOI: 10.1016/J.Jns.2013.05.028  0.706
2013 Irwin DJ, Lee VM, Trojanowski JQ. Parkinson's disease dementia: convergence of α-synuclein, tau and amyloid-β pathologies. Nature Reviews. Neuroscience. 14: 626-36. PMID 23900411 DOI: 10.1038/Nrn3549  0.452
2013 Irwin DJ, Cohen TJ, Grossman M, Arnold SE, McCarty-Wood E, Van Deerlin VM, Lee VM, Trojanowski JQ. Acetylated tau neuropathology in sporadic and hereditary tauopathies. The American Journal of Pathology. 183: 344-51. PMID 23885714 DOI: 10.1016/J.Ajpath.2013.04.025  0.57
2013 Arnold SE, Toledo JB, Appleby DH, Xie SX, Wang LS, Baek Y, Wolk DA, Lee EB, Miller BL, Lee VM, Trojanowski JQ. Comparative survey of the topographical distribution of signature molecular lesions in major neurodegenerative diseases. The Journal of Comparative Neurology. 521: 4339-55. PMID 23881776 DOI: 10.1002/Cne.23430  0.651
2013 Guo JL, Covell DJ, Daniels JP, Iba M, Stieber A, Zhang B, Riddle DM, Kwong LK, Xu Y, Trojanowski JQ, Lee VM. Distinct α-synuclein strains differentially promote tau inclusions in neurons. Cell. 154: 103-17. PMID 23827677 DOI: 10.1016/J.Cell.2013.05.057  0.564
2013 Dryanovski DI, Guzman JN, Xie Z, Galteri DJ, Volpicelli-Daley LA, Lee VM, Miller RJ, Schumacker PT, Surmeier DJ. Calcium entry and α-synuclein inclusions elevate dendritic mitochondrial oxidant stress in dopaminergic neurons. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 33: 10154-64. PMID 23761910 DOI: 10.1523/Jneurosci.5311-12.2013  0.633
2013 Chahine LM, Qiang J, Ashbridge E, Minger J, Yearout D, Horn S, Colcher A, Hurtig HI, Lee VM, Van Deerlin VM, Leverenz JB, Siderowf AD, Trojanowski JQ, Zabetian CP, Chen-Plotkin A. Clinical and biochemical differences in patients having Parkinson disease with vs without GBA mutations. Jama Neurology. 70: 852-8. PMID 23699752 DOI: 10.1001/Jamaneurol.2013.1274  0.601
2013 Brettschneider J, Del Tredici K, Toledo JB, Robinson JL, Irwin DJ, Grossman M, Suh E, Van Deerlin VM, Wood EM, Baek Y, Kwong L, Lee EB, Elman L, McCluskey L, Fang L, ... ... Lee VM, et al. Stages of pTDP-43 pathology in amyotrophic lateral sclerosis. Annals of Neurology. 74: 20-38. PMID 23686809 DOI: 10.1002/Ana.23937  0.645
2013 Cohen TJ, Friedmann D, Hwang AW, Marmorstein R, Lee VM. The microtubule-associated tau protein has intrinsic acetyltransferase activity. Nature Structural & Molecular Biology. 20: 756-62. PMID 23624859 DOI: 10.1038/Nsmb.2555  0.32
2013 Cruchaga C, Kauwe JS, Harari O, Jin SC, Cai Y, Karch CM, Benitez BA, Jeng AT, Skorupa T, Carrell D, Bertelsen S, Bailey M, McKean D, Shulman JM, De Jager PL, ... ... Lee VM, et al. GWAS of cerebrospinal fluid tau levels identifies risk variants for Alzheimer's disease. Neuron. 78: 256-68. PMID 23562540 DOI: 10.1016/J.Neuron.2013.02.026  0.392
2013 Tanik SA, Schultheiss CE, Volpicelli-Daley LA, Brunden KR, Lee VM. Lewy body-like α-synuclein aggregates resist degradation and impair macroautophagy. The Journal of Biological Chemistry. 288: 15194-210. PMID 23532841 DOI: 10.1074/Jbc.M113.457408  0.814
2013 McMillan CT, Irwin DJ, Avants BB, Powers J, Cook PA, Toledo JB, McCarty Wood E, Van Deerlin VM, Lee VM, Trojanowski JQ, Grossman M. White matter imaging helps dissociate tau from TDP-43 in frontotemporal lobar degeneration. Journal of Neurology, Neurosurgery, and Psychiatry. 84: 949-55. PMID 23475817 DOI: 10.1136/Jnnp-2012-304418  0.607
2013 Berlau DJ, Corrada MM, Robinson JL, Geser F, Arnold SE, Lee VM, Kawas CH, Trojanowski JQ. Neocortical β-amyloid area is associated with dementia and APOE in the oldest-old. Alzheimer's & Dementia : the Journal of the Alzheimer's Association. 9: 699-705. PMID 23474043 DOI: 10.1016/J.Jalz.2012.11.011  0.425
2013 Qiang JK, Wong YC, Siderowf A, Hurtig HI, Xie SX, Lee VM, Trojanowski JQ, Yearout D, B Leverenz J, Montine TJ, Stern M, Mendick S, Jennings D, Zabetian C, Marek K, et al. Plasma apolipoprotein A1 as a biomarker for Parkinson disease. Annals of Neurology. 74: 119-27. PMID 23447138 DOI: 10.1002/Ana.23872  0.591
2013 Crowe A, James MJ, Lee VM, Smith AB, Trojanowski JQ, Ballatore C, Brunden KR. Aminothienopyridazines and methylene blue affect Tau fibrillization via cysteine oxidation. The Journal of Biological Chemistry. 288: 11024-37. PMID 23443659 DOI: 10.1074/Jbc.M112.436006  0.445
2013 Guo JL, Lee VM. Neurofibrillary tangle-like tau pathology induced by synthetic tau fibrils in primary neurons over-expressing mutant tau. Febs Letters. 587: 717-23. PMID 23395797 DOI: 10.1016/j.febslet.2013.01.051  0.445
2013 Irwin DJ, Abrams JY, Schonberger LB, Leschek EW, Mills JL, Lee VM, Trojanowski JQ. Evaluation of potential infectivity of Alzheimer and Parkinson disease proteins in recipients of cadaver-derived human growth hormone. Jama Neurology. 70: 462-8. PMID 23380910 DOI: 10.1001/Jamaneurol.2013.1933  0.417
2013 Iba M, Guo JL, McBride JD, Zhang B, Trojanowski JQ, Lee VM. Synthetic tau fibrils mediate transmission of neurofibrillary tangles in a transgenic mouse model of Alzheimer's-like tauopathy. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 33: 1024-37. PMID 23325240 DOI: 10.1523/Jneurosci.2642-12.2013  0.564
2013 Kling MA, Trojanowski JQ, Wolk DA, Lee VM, Arnold SE. Vascular disease and dementias: paradigm shifts to drive research in new directions. Alzheimer's & Dementia : the Journal of the Alzheimer's Association. 9: 76-92. PMID 23183137 DOI: 10.1016/J.Jalz.2012.02.007  0.407
2013 Robinson JL, Geser F, Stieber A, Umoh M, Kwong LK, Van Deerlin VM, Lee VM, Trojanowski JQ. TDP-43 skeins show properties of amyloid in a subset of ALS cases. Acta Neuropathologica. 125: 121-31. PMID 23124365 DOI: 10.1007/S00401-012-1055-8  0.442
2013 Irwin DJ, McMillan CT, Brettschneider J, Libon DJ, Powers J, Rascovsky K, Toledo JB, Boller A, Bekisz J, Chandrasekaran K, Wood EM, Shaw LM, Woo JH, Cook PA, Wolk DA, ... ... Lee VM, et al. Cognitive decline and reduced survival in C9orf72 expansion frontotemporal degeneration and amyotrophic lateral sclerosis. Journal of Neurology, Neurosurgery, and Psychiatry. 84: 163-9. PMID 23117491 DOI: 10.1136/Jnnp-2012-303507  0.504
2013 Yoshiyama Y, Lee VM, Trojanowski JQ. Therapeutic strategies for tau mediated neurodegeneration. Journal of Neurology, Neurosurgery, and Psychiatry. 84: 784-95. PMID 23085937 DOI: 10.1136/Jnnp-2012-303144  0.465
2013 Lee VM. Transmission of alpha-synuclein in Parkinson’s disease Molecular Neurodegeneration. 8: 1-1. DOI: 10.1186/1750-1326-8-S1-O25  0.395
2013 Ryvkin P, Leung YY, Dragomir I, Schuck T, Schellenberg G, Arnold S, Chen-Plotkin A, Van Deerlin V, Lee V, Trojanowski J, Gregory B, Wang L. P3-064: Characterizing the Alzheimer's disease prefrontal cortex transcriptome by multiple RNA-sequencing Alzheimer's & Dementia. 9: P574-P574. DOI: 10.1016/J.Jalz.2013.05.1134  0.63
2013 Leung YY, Toledo J, Nefedov A, Polikar R, Raghavan N, Xie S, Farnum M, Schultz T, Baek Y, Lobanov V, DiBernardo A, Deerlin VV, Kling M, Chen-Plotkin A, Mailman M, ... ... Lee V, et al. Identifying multi-analyte CSF biomarkers for Alzheimer’s disease in a multi-cohort study Alzheimers & Dementia. 9. DOI: 10.1016/J.Jalz.2013.04.059  0.745
2012 Yarchoan M, Xie SX, Kling MA, Toledo JB, Wolk DA, Lee EB, Van Deerlin V, Lee VM, Trojanowski JQ, Arnold SE. Cerebrovascular atherosclerosis correlates with Alzheimer pathology in neurodegenerative dementias. Brain : a Journal of Neurology. 135: 3749-56. PMID 23204143 DOI: 10.1093/Brain/Aws271  0.667
2012 Soper JH, Sugiyama S, Herbst-Robinson K, James MJ, Wang X, Trojanowski JQ, Smith AB, Lee VM, Ballatore C, Brunden KR. Brain-penetrant tetrahydronaphthalene thromboxane A2-prostanoid (TP) receptor antagonists as prototype therapeutics for Alzheimer's disease. Acs Chemical Neuroscience. 3: 928-40. PMID 23173073 DOI: 10.1021/Cn3000795  0.796
2012 Luk KC, Kehm V, Carroll J, Zhang B, O'Brien P, Trojanowski JQ, Lee VM. Pathological α-synuclein transmission initiates Parkinson-like neurodegeneration in nontransgenic mice. Science (New York, N.Y.). 338: 949-53. PMID 23161999 DOI: 10.1126/Science.1227157  0.437
2012 Trojanowski JQ, Arnold SE, Karlawish JH, Naylor M, Brunden KR, Lee VM. A model for improving the treatment and care of Alzheimer's disease patients through interdisciplinary research. Alzheimer's & Dementia : the Journal of the Alzheimer's Association. 8: 564-73. PMID 23102127 DOI: 10.1016/J.Jalz.2011.08.005  0.368
2012 Toledo JB, Toledo E, Weiner MW, Jack CR, Jagust W, Lee VM, Shaw LM, Trojanowski JQ. Cardiovascular risk factors, cortisol, and amyloid-β deposition in Alzheimer's Disease Neuroimaging Initiative. Alzheimer's & Dementia : the Journal of the Alzheimer's Association. 8: 483-9. PMID 23102118 DOI: 10.1016/J.Jalz.2011.08.008  0.37
2012 Irwin DJ, White MT, Toledo JB, Xie SX, Robinson JL, Van Deerlin V, Lee VM, Leverenz JB, Montine TJ, Duda JE, Hurtig HI, Trojanowski JQ. Neuropathologic substrates of Parkinson disease dementia. Annals of Neurology. 72: 587-98. PMID 23037886 DOI: 10.1002/Ana.23659  0.414
2012 Ballatore C, Brunden KR, Huryn DM, Trojanowski JQ, Lee VM, Smith AB. Microtubule stabilizing agents as potential treatment for Alzheimer's disease and related neurodegenerative tauopathies. Journal of Medicinal Chemistry. 55: 8979-96. PMID 23020671 DOI: 10.1021/Jm301079Z  0.399
2012 Naylor MD, Karlawish JH, Arnold SE, Khachaturian AS, Khachaturian ZS, Lee VM, Baumgart M, Banerjee S, Beck C, Blennow K, Brookmeyer R, Brunden KR, Buckwalter KC, Comer M, Covinsky K, et al. Advancing Alzheimer's disease diagnosis, treatment, and care: recommendations from the Ware Invitational Summit. Alzheimer's & Dementia : the Journal of the Alzheimer's Association. 8: 445-52. PMID 22959699 DOI: 10.1016/J.Jalz.2012.08.001  0.357
2012 Chen-Plotkin AS, Unger TL, Gallagher MD, Bill E, Kwong LK, Volpicelli-Daley L, Busch JI, Akle S, Grossman M, Van Deerlin V, Trojanowski JQ, Lee VM. TMEM106B, the risk gene for frontotemporal dementia, is regulated by the microRNA-132/212 cluster and affects progranulin pathways. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 32: 11213-27. PMID 22895706 DOI: 10.1523/Jneurosci.0521-12.2012  0.791
2012 Hu WT, Holtzman DM, Fagan AM, Shaw LM, Perrin R, Arnold SE, Grossman M, Xiong C, Craig-Schapiro R, Clark CM, Pickering E, Kuhn M, Chen Y, Van Deerlin VM, McCluskey L, ... ... Lee VM, et al. Plasma multianalyte profiling in mild cognitive impairment and Alzheimer disease. Neurology. 79: 897-905. PMID 22855860 DOI: 10.1212/Wnl.0B013E318266Fa70  0.756
2012 Arnold SE, Xie SX, Leung YY, Wang LS, Kling MA, Han X, Kim EJ, Wolk DA, Bennett DA, Chen-Plotkin A, Grossman M, Hu W, Lee VM, Mackin RS, Trojanowski JQ, et al. Plasma biomarkers of depressive symptoms in older adults. Translational Psychiatry. 2: e65. PMID 22832727 DOI: 10.1038/Tp.2011.63  0.711
2012 Brunden KR, Ballatore C, Lee VM, Smith AB, Trojanowski JQ. Brain-penetrant microtubule-stabilizing compounds as potential therapeutic agents for tauopathies. Biochemical Society Transactions. 40: 661-6. PMID 22817712 DOI: 10.1042/Bst20120010  0.444
2012 Cooper O, Seo H, Andrabi S, Guardia-Laguarta C, Graziotto J, Sundberg M, McLean JR, Carrillo-Reid L, Xie Z, Osborn T, Hargus G, Deleidi M, Lawson T, Bogetofte H, Perez-Torres E, ... ... Lee VM, et al. Pharmacological rescue of mitochondrial deficits in iPSC-derived neural cells from patients with familial Parkinson's disease. Science Translational Medicine. 4: 141ra90. PMID 22764206 DOI: 10.1126/Scitranslmed.3003985  0.672
2012 Figurski MJ, Waligórska T, Toledo J, Vanderstichele H, Korecka M, Lee VM, Trojanowski JQ, Shaw LM. Improved protocol for measurement of plasma β-amyloid in longitudinal evaluation of Alzheimer's Disease Neuroimaging Initiative study patients. Alzheimer's & Dementia : the Journal of the Alzheimer's Association. 8: 250-60. PMID 22748936 DOI: 10.1016/J.Jalz.2012.01.001  0.323
2012 Brettschneider J, Toledo JB, Van Deerlin VM, Elman L, McCluskey L, Lee VM, Trojanowski JQ. Microglial activation correlates with disease progression and upper motor neuron clinical symptoms in amyotrophic lateral sclerosis. Plos One. 7: e39216. PMID 22720079 DOI: 10.1371/Journal.Pone.0039216  0.413
2012 Ballatore C, Crowe A, Piscitelli F, James M, Lou K, Rossidivito G, Yao Y, Trojanowski JQ, Lee VM, Brunden KR, Smith AB. Aminothienopyridazine inhibitors of tau aggregation: evaluation of structure-activity relationship leads to selection of candidates with desirable in vivo properties. Bioorganic & Medicinal Chemistry. 20: 4451-61. PMID 22717239 DOI: 10.1016/J.Bmc.2012.05.027  0.344
2012 Koffie RM, Hashimoto T, Tai HC, Kay KR, Serrano-Pozo A, Joyner D, Hou S, Kopeikina KJ, Frosch MP, Lee VM, Holtzman DM, Hyman BT, Spires-Jones TL. Apolipoprotein E4 effects in Alzheimer's disease are mediated by synaptotoxic oligomeric amyloid-β. Brain : a Journal of Neurology. 135: 2155-68. PMID 22637583 DOI: 10.1093/Brain/Aws127  0.396
2012 Hurtado DE, Molina-Porcel L, Carroll JC, Macdonald C, Aboagye AK, Trojanowski JQ, Lee VM. Selectively silencing GSK-3 isoforms reduces plaques and tangles in mouse models of Alzheimer's disease. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 32: 7392-402. PMID 22623685 DOI: 10.1523/Jneurosci.0889-12.2012  0.768
2012 Wang LS, Leung YY, Chang SK, Leight S, Knapik-Czajka M, Baek Y, Shaw LM, Lee VM, Trojanowski JQ, Clark CM. Comparison of xMAP and ELISA assays for detecting cerebrospinal fluid biomarkers of Alzheimer's disease. Journal of Alzheimer's Disease : Jad. 31: 439-45. PMID 22571982 DOI: 10.3233/Jad-2012-120082  0.436
2012 Coppola G, Chinnathambi S, Lee JJ, Dombroski BA, Baker MC, Soto-Ortolaza AI, Lee SE, Klein E, Huang AY, Sears R, Lane JR, Karydas AM, Kenet RO, Biernat J, Wang LS, ... ... Lee VM, et al. Evidence for a role of the rare p.A152T variant in MAPT in increasing the risk for FTD-spectrum and Alzheimer's diseases. Human Molecular Genetics. 21: 3500-12. PMID 22556362 DOI: 10.1093/Hmg/Dds161  0.529
2012 Hart MP, Brettschneider J, Lee VM, Trojanowski JQ, Gitler AD. Distinct TDP-43 pathology in ALS patients with ataxin 2 intermediate-length polyQ expansions. Acta Neuropathologica. 124: 221-30. PMID 22526021 DOI: 10.1007/S00401-012-0985-5  0.392
2012 Toledo JB, Brettschneider J, Grossman M, Arnold SE, Hu WT, Xie SX, Lee VM, Shaw LM, Trojanowski JQ. CSF biomarkers cutoffs: the importance of coincident neuropathological diseases. Acta Neuropathologica. 124: 23-35. PMID 22526019 DOI: 10.1007/S00401-012-0983-7  0.686
2012 Luk KC, Kehm VM, Zhang B, O'Brien P, Trojanowski JQ, Lee VM. Intracerebral inoculation of pathological α-synuclein initiates a rapidly progressive neurodegenerative α-synucleinopathy in mice. The Journal of Experimental Medicine. 209: 975-86. PMID 22508839 DOI: 10.1084/Jem.20112457  0.454
2012 Irwin DJ, McMillan CT, Toledo JB, Arnold SE, Shaw LM, Wang LS, Van Deerlin V, Lee VM, Trojanowski JQ, Grossman M. Comparison of cerebrospinal fluid levels of tau and Aβ 1-42 in Alzheimer disease and frontotemporal degeneration using 2 analytical platforms. Archives of Neurology. 69: 1018-25. PMID 22490326 DOI: 10.1001/Archneurol.2012.26  0.575
2012 Couthouis J, Hart MP, Erion R, King OD, Diaz Z, Nakaya T, Ibrahim F, Kim HJ, Mojsilovic-Petrovic J, Panossian S, Kim CE, Frackelton EC, Solski JA, Williams KL, Clay-Falcone D, ... ... Lee VM, et al. Evaluating the role of the FUS/TLS-related gene EWSR1 in amyotrophic lateral sclerosis. Human Molecular Genetics. 21: 2899-911. PMID 22454397 DOI: 10.1093/Hmg/Dds116  0.615
2012 Brettschneider J, Van Deerlin VM, Robinson JL, Kwong L, Lee EB, Ali YO, Safren N, Monteiro MJ, Toledo JB, Elman L, McCluskey L, Irwin DJ, Grossman M, Molina-Porcel L, Lee VM, et al. Pattern of ubiquilin pathology in ALS and FTLD indicates presence of C9ORF72 hexanucleotide expansion. Acta Neuropathologica. 123: 825-39. PMID 22426854 DOI: 10.1007/S00401-012-0970-Z  0.689
2012 Zhang B, Carroll J, Trojanowski JQ, Yao Y, Iba M, Potuzak JS, Hogan AM, Xie SX, Ballatore C, Smith AB, Lee VM, Brunden KR. The microtubule-stabilizing agent, epothilone D, reduces axonal dysfunction, neurotoxicity, cognitive deficits, and Alzheimer-like pathology in an interventional study with aged tau transgenic mice. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 32: 3601-11. PMID 22423084 DOI: 10.1523/Jneurosci.4922-11.2012  0.447
2012 Irwin DJ, Cohen TJ, Grossman M, Arnold SE, Xie SX, Lee VM, Trojanowski JQ. Acetylated tau, a novel pathological signature in Alzheimer's disease and other tauopathies. Brain : a Journal of Neurology. 135: 807-18. PMID 22366796 DOI: 10.1093/Brain/Aws013  0.61
2012 Wang Y, Shi M, Chung KA, Zabetian CP, Leverenz JB, Berg D, Srulijes K, Trojanowski JQ, Lee VM, Siderowf AD, Hurtig H, Litvan I, Schiess MC, Peskind ER, Masuda M, et al. Phosphorylated α-synuclein in Parkinson's disease. Science Translational Medicine. 4: 121ra20. PMID 22344688 DOI: 10.1126/Scitranslmed.3002566  0.35
2012 Bakken TE, Roddey JC, Djurovic S, Akshoomoff N, Amaral DG, Bloss CS, Casey BJ, Chang L, Ernst TM, Gruen JR, Jernigan TL, Kaufmann WE, Kenet T, Kennedy DN, Kuperman JM, ... ... Lee VM, et al. Association of common genetic variants in GPCPD1 with scaling of visual cortical surface area in humans. Proceedings of the National Academy of Sciences of the United States of America. 109: 3985-90. PMID 22343285 DOI: 10.1073/Pnas.1105829109  0.433
2012 Martinez-Lage M, Molina-Porcel L, Falcone D, McCluskey L, Lee VM, Van Deerlin VM, Trojanowski JQ. TDP-43 pathology in a case of hereditary spastic paraplegia with a NIPA1/SPG6 mutation. Acta Neuropathologica. 124: 285-91. PMID 22302102 DOI: 10.1007/S00401-012-0947-Y  0.365
2012 Brettschneider J, Libon DJ, Toledo JB, Xie SX, McCluskey L, Elman L, Geser F, Lee VM, Grossman M, Trojanowski JQ. Microglial activation and TDP-43 pathology correlate with executive dysfunction in amyotrophic lateral sclerosis. Acta Neuropathologica. 123: 395-407. PMID 22210083 DOI: 10.1007/S00401-011-0932-X  0.555
2012 Cohen TJ, Hwang AW, Unger T, Trojanowski JQ, Lee VM. Redox signalling directly regulates TDP-43 via cysteine oxidation and disulphide cross-linking. The Embo Journal. 31: 1241-52. PMID 22193716 DOI: 10.1038/Emboj.2011.471  0.37
2012 Lee EB, Lee VM, Trojanowski JQ. Gains or losses: molecular mechanisms of TDP43-mediated neurodegeneration. Nature Reviews. Neuroscience. 13: 38-50. PMID 22127299 DOI: 10.1038/Nrn3121  0.623
2012 Chahine L, Ashbridge E, Minger J, Yearout D, Qiang J, Siderowf A, Hurtig H, Zabetian C, Lee V, Van Deerlin V, Trojanowski J, Chen-Plotkin A. Clinical and Biochemical Differences between Parkinson's Disease Patients With and Without Mutations in the Glucocerebrosidase Gene (P06.072) Neurology. 78: P06.072-P06.072. DOI: 10.1212/Wnl.78.1_Meetingabstracts.P06.072  0.647
2012 Farnum M, Baek Y, Schultz T, Nefedov A, Xie S, Leung YY, Toledo J, Raghavan N, Chen-Plotkin A, Wolk D, Polikar R, DiBernardo A, Siderowf A, Davatzikos C, Van Deerlin V, ... ... Lee V, et al. P1-006: An integrated approach to the development of biomarkers for Alzheimer's disease using hospital population data Alzheimer's & Dementia. 8: P109-P109. DOI: 10.1016/J.Jalz.2012.05.281  0.688
2012 Leung YY, Wang L, Hu WT, Kling M, Wolk D, Trojanowski J, Lee V, Shaw L, Arnold S. P2-049: Cerebrospinal fluid biochemical biomarkers of depressive symptoms in older adults Alzheimer's & Dementia. 8: P280-P280. DOI: 10.1016/J.Jalz.2012.05.2143  0.54
2012 Nefedov A, Toledo J, Leung YY, Raghavan N, Xie S, Polikar R, Farnum M, Schultz T, Baek Y, Lobanov V, DiBernardo A, Narayan V, Lee V, Arnold S, Trojanowski J, et al. P3-101: Neuropathological subtypes among subjects with Alzheimer's disease Alzheimer's & Dementia. 8: P488-P488. DOI: 10.1016/J.Jalz.2012.05.1321  0.47
2012 Stutzbach L, Hawk M, Gilman S, Lee V, Trojanowski J, Schellenberg G. ER stress in Alzheimer's disease and PSP: Common disease mechanism? Alzheimers & Dementia. 8. DOI: 10.1016/J.Jalz.2012.05.1234  0.463
2011 Lee VM, Brunden KR, Hutton M, Trojanowski JQ. Developing therapeutic approaches to tau, selected kinases, and related neuronal protein targets. Cold Spring Harbor Perspectives in Medicine. 1: a006437. PMID 22229117 DOI: 10.1101/Cshperspect.A006437  0.558
2011 Robinson JL, Geser F, Corrada MM, Berlau DJ, Arnold SE, Lee VM, Kawas CH, Trojanowski JQ. Neocortical and hippocampal amyloid-β and tau measures associate with dementia in the oldest-old. Brain : a Journal of Neurology. 134: 3708-15. PMID 22120149 DOI: 10.1093/Brain/Awr308  0.475
2011 Couthouis J, Hart MP, Shorter J, DeJesus-Hernandez M, Erion R, Oristano R, Liu AX, Ramos D, Jethava N, Hosangadi D, Epstein J, Chiang A, Diaz Z, Nakaya T, Ibrahim F, ... ... Lee VM, et al. A yeast functional screen predicts new candidate ALS disease genes. Proceedings of the National Academy of Sciences of the United States of America. 108: 20881-90. PMID 22065782 DOI: 10.1073/Pnas.1109434108  0.59
2011 Volpicelli-Daley LA, Luk KC, Patel TP, Tanik SA, Riddle DM, Stieber A, Meaney DF, Trojanowski JQ, Lee VM. Exogenous α-synuclein fibrils induce Lewy body pathology leading to synaptic dysfunction and neuron death. Neuron. 72: 57-71. PMID 21982369 DOI: 10.1016/J.Neuron.2011.08.033  0.811
2011 Carroll JC, Iba M, Bangasser DA, Valentino RJ, James MJ, Brunden KR, Lee VM, Trojanowski JQ. Chronic stress exacerbates tau pathology, neurodegeneration, and cognitive performance through a corticotropin-releasing factor receptor-dependent mechanism in a transgenic mouse model of tauopathy. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 31: 14436-49. PMID 21976528 DOI: 10.1523/Jneurosci.3836-11.2011  0.398
2011 Yamada K, Cirrito JR, Stewart FR, Jiang H, Finn MB, Holmes BB, Binder LI, Mandelkow EM, Diamond MI, Lee VM, Holtzman DM. In vivo microdialysis reveals age-dependent decrease of brain interstitial fluid tau levels in P301S human tau transgenic mice. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 31: 13110-7. PMID 21917794 DOI: 10.1523/Jneurosci.2569-11.2011  0.319
2011 Ballatore C, Soper JH, Piscitelli F, James M, Huang L, Atasoylu O, Huryn DM, Trojanowski JQ, Lee VM, Brunden KR, Smith AB. Cyclopentane-1,3-dione: a novel isostere for the carboxylic acid functional group. Application to the design of potent thromboxane (A2) receptor antagonists. Journal of Medicinal Chemistry. 54: 6969-83. PMID 21863799 DOI: 10.1021/Jm200980U  0.756
2011 Toledo JB, Vanderstichele H, Figurski M, Aisen PS, Petersen RC, Weiner MW, Jack CR, Jagust W, Decarli C, Toga AW, Toledo E, Xie SX, Lee VM, Trojanowski JQ, Shaw LM, et al. Factors affecting Aβ plasma levels and their utility as biomarkers in ADNI. Acta Neuropathologica. 122: 401-13. PMID 21805181 DOI: 10.1007/S00401-011-0861-8  0.336
2011 Xie SX, Baek Y, Grossman M, Arnold SE, Karlawish J, Siderowf A, Hurtig H, Elman L, McCluskey L, Van Deerlin V, Lee VM, Trojanowski JQ. Building an integrated neurodegenerative disease database at an academic health center. Alzheimer's & Dementia : the Journal of the Alzheimer's Association. 7: e84-93. PMID 21784346 DOI: 10.1016/J.Jalz.2010.08.233  0.544
2011 Cohen TJ, Lee VM, Trojanowski JQ. TDP-43 functions and pathogenic mechanisms implicated in TDP-43 proteinopathies. Trends in Molecular Medicine. 17: 659-67. PMID 21783422 DOI: 10.1016/J.Molmed.2011.06.004  0.366
2011 Lim Y, Kehm VM, Lee EB, Soper JH, Li C, Trojanowski JQ, Lee VM. α-Syn suppression reverses synaptic and memory defects in a mouse model of dementia with Lewy bodies. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 31: 10076-87. PMID 21734300 DOI: 10.1523/Jneurosci.0618-11.2011  0.804
2011 Takeuchi H, Iba M, Inoue H, Higuchi M, Takao K, Tsukita K, Karatsu Y, Iwamoto Y, Miyakawa T, Suhara T, Trojanowski JQ, Lee VM, Takahashi R. P301S mutant human tau transgenic mice manifest early symptoms of human tauopathies with dementia and altered sensorimotor gating. Plos One. 6: e21050. PMID 21698260 DOI: 10.1371/Journal.Pone.0021050  0.46
2011 Mackenzie IR, Neumann M, Baborie A, Sampathu DM, Du Plessis D, Jaros E, Perry RH, Trojanowski JQ, Mann DM, Lee VM. A harmonized classification system for FTLD-TDP pathology. Acta Neuropathologica. 122: 111-3. PMID 21644037 DOI: 10.1007/S00401-011-0845-8  0.807
2011 Winton MJ, Lee EB, Sun E, Wong MM, Leight S, Zhang B, Trojanowski JQ, Lee VM. Intraneuronal APP, not free Aβ peptides in 3xTg-AD mice: implications for tau versus Aβ-mediated Alzheimer neurodegeneration. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 31: 7691-9. PMID 21613482 DOI: 10.1523/Jneurosci.6637-10.2011  0.639
2011 Takasugi N, Sasaki T, Suzuki K, Osawa S, Isshiki H, Hori Y, Shimada N, Higo T, Yokoshima S, Fukuyama T, Lee VM, Trojanowski JQ, Tomita T, Iwatsubo T. BACE1 activity is modulated by cell-associated sphingosine-1-phosphate. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 31: 6850-7. PMID 21543615 DOI: 10.1016/J.Jalz.2011.05.1193  0.435
2011 Chen-Plotkin AS, Hu WT, Siderowf A, Weintraub D, Goldmann Gross R, Hurtig HI, Xie SX, Arnold SE, Grossman M, Clark CM, Shaw LM, McCluskey L, Elman L, Van Deerlin VM, Lee VM, et al. Plasma epidermal growth factor levels predict cognitive decline in Parkinson disease. Annals of Neurology. 69: 655-63. PMID 21520231 DOI: 10.1002/Ana.22271  0.719
2011 Chen-Plotkin AS, Martinez-Lage M, Sleiman PM, Hu W, Greene R, Wood EM, Bing S, Grossman M, Schellenberg GD, Hatanpaa KJ, Weiner MF, White CL, Brooks WS, Halliday GM, Kril JJ, ... ... Lee VM, et al. Genetic and clinical features of progranulin-associated frontotemporal lobar degeneration. Archives of Neurology. 68: 488-97. PMID 21482928 DOI: 10.1001/Archneurol.2011.53  0.721
2011 Yu Z, Zhu Y, Chen-Plotkin AS, Clay-Falcone D, McCluskey L, Elman L, Kalb RG, Trojanowski JQ, Lee VM, Van Deerlin VM, Gitler AD, Bonini NM. PolyQ repeat expansions in ATXN2 associated with ALS are CAA interrupted repeats. Plos One. 6: e17951. PMID 21479228 DOI: 10.1371/Journal.Pone.0017951  0.602
2011 Pesiridis GS, Tripathy K, Tanik S, Trojanowski JQ, Lee VM. A "two-hit" hypothesis for inclusion formation by carboxyl-terminal fragments of TDP-43 protein linked to RNA depletion and impaired microtubule-dependent transport. The Journal of Biological Chemistry. 286: 18845-55. PMID 21454607 DOI: 10.1074/Jbc.M111.231118  0.787
2011 Maeda J, Zhang MR, Okauchi T, Ji B, Ono M, Hattori S, Kumata K, Iwata N, Saido TC, Trojanowski JQ, Lee VM, Staufenbiel M, Tomiyama T, Mori H, Fukumura T, et al. In vivo positron emission tomographic imaging of glial responses to amyloid-beta and tau pathologies in mouse models of Alzheimer's disease and related disorders. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 31: 4720-30. PMID 21430171 DOI: 10.1523/Jneurosci.3076-10.2011  0.48
2011 Cohen TJ, Guo JL, Hurtado DE, Kwong LK, Mills IP, Trojanowski JQ, Lee VM. The acetylation of tau inhibits its function and promotes pathological tau aggregation. Nature Communications. 2: 252. PMID 21427723 DOI: 10.1038/Ncomms1255  0.808
2011 Guo JL, Lee VM. Seeding of normal Tau by pathological Tau conformers drives pathogenesis of Alzheimer-like tangles. The Journal of Biological Chemistry. 286: 15317-31. PMID 21372138 DOI: 10.1074/jbc.M110.209296  0.465
2011 Ballatore C, Brunden KR, Trojanowski JQ, Lee VM, Smith AB, Huryn DM. Modulation of protein-protein interactions as a therapeutic strategy for the treatment of neurodegenerative tauopathies. Current Topics in Medicinal Chemistry. 11: 317-30. PMID 21320060 DOI: 10.2174/156802611794072605  0.462
2011 Shaw LM, Vanderstichele H, Knapik-Czajka M, Figurski M, Coart E, Blennow K, Soares H, Simon AJ, Lewczuk P, Dean RA, Siemers E, Potter W, Lee VM, Trojanowski JQ. Qualification of the analytical and clinical performance of CSF biomarker analyses in ADNI. Acta Neuropathologica. 121: 597-609. PMID 21311900 DOI: 10.1007/S00401-011-0808-0  0.434
2011 Geser F, Stein B, Partain M, Elman LB, McCluskey LF, Xie SX, Van Deerlin VM, Kwong LK, Lee VM, Trojanowski JQ. Motor neuron disease clinically limited to the lower motor neuron is a diffuse TDP-43 proteinopathy. Acta Neuropathologica. 121: 509-17. PMID 21225272 DOI: 10.1007/S00401-011-0797-Z  0.414
2011 Igaz LM, Kwong LK, Lee EB, Chen-Plotkin A, Swanson E, Unger T, Malunda J, Xu Y, Winton MJ, Trojanowski JQ, Lee VM. Dysregulation of the ALS-associated gene TDP-43 leads to neuronal death and degeneration in mice. The Journal of Clinical Investigation. 121: 726-38. PMID 21206091 DOI: 10.1172/Jci44867  0.806
2011 Brunden KR, Yao Y, Potuzak JS, Ferrer NI, Ballatore C, James MJ, Hogan AM, Trojanowski JQ, Smith AB, Lee VM. The characterization of microtubule-stabilizing drugs as possible therapeutic agents for Alzheimer's disease and related tauopathies. Pharmacological Research : the Official Journal of the Italian Pharmacological Society. 63: 341-51. PMID 21163349 DOI: 10.1016/J.Phrs.2010.12.002  0.455
2011 Vass R, Ashbridge E, Geser F, Hu WT, Grossman M, Clay-Falcone D, Elman L, McCluskey L, Lee VM, Van Deerlin VM, Trojanowski JQ, Chen-Plotkin AS. Risk genotypes at TMEM106B are associated with cognitive impairment in amyotrophic lateral sclerosis. Acta Neuropathologica. 121: 373-80. PMID 21104415 DOI: 10.1007/S00401-010-0782-Y  0.723
2011 Geser F, Malunda JA, Hurtig HI, Duda JE, Wenning GK, Gilman S, Low PA, Lee VM, Trojanowski JQ. TDP-43 pathology occurs infrequently in multiple system atrophy. Neuropathology and Applied Neurobiology. 37: 358-65. PMID 20942898 DOI: 10.1111/J.1365-2990.2010.01136.X  0.445
2011 Soper JH, Kehm V, Burd CG, Bankaitis VA, Lee VM. Aggregation of α-synuclein in S. cerevisiae is associated with defects in endosomal trafficking and phospholipid biosynthesis. Journal of Molecular Neuroscience : Mn. 43: 391-405. PMID 20890676 DOI: 10.1007/S12031-010-9455-5  0.816
2011 Soares H, Potter W, Immermann F, Pickering E, Kuhn M, Shera D, Zagouras P, Swenson F, Wan H, Ferm M, Siuciak J, Koroshetz W, Simon A, Lee V, Buckholtz N, et al. Changes in plasma based biomarkers in Alzheimer's disease, mild cognitively impaired and aged matched normal controls from the ADNI cohort Alzheimers & Dementia. 7. DOI: 10.1016/J.Jalz.2011.05.960  0.607
2011 Arnold S, Xie SX, Leung Y, Kim E, Kling M, Wilson R, Bennett D, Hu W, Mackin S, Grossman M, Chen-Plotkin A, Wolk D, Lee V, Trojanowski J, Shaw L. P2-017: Biochemical Biomarkers of Depressive Symptoms in ADNI Alzheimer's & Dementia. 7: S312-S312. DOI: 10.1016/J.Jalz.2011.05.907  0.708
2011 Hu WT, Holtzman D, Clark C, Grossman M, Karlawish J, Fagan A, Lee V, Swenson F, Craig-Schapiro R, Perrin RJ, Soares H, Trojanowski J, Xiong C, Morris J, Shaw L, et al. P1-089: Plasma multianalyte profiling of mild cognitive impairment and Alzheimer's disease in two academic centers and the Alzheimer's Disease Neuroimaging Initiative Alzheimer's & Dementia. 7: S138-S138. DOI: 10.1016/J.Jalz.2011.05.368  0.764
2011 Holtzman D, Hyman B, Lee V, Spires-Jones T, Koffie R, Hashimoto T, Joyner D, Hou S, Kopeikina K, Frosch M. O1-05-01: APOE4 plays a role in Abeta-mediated synapse loss in Alzheimer's disease Alzheimer's & Dementia. 7: S103-S104. DOI: 10.1016/J.Jalz.2011.05.256  0.356
2010 Hu WT, Chen-Plotkin A, Grossman M, Arnold SE, Clark CM, Shaw LM, McCluskey L, Elman L, Hurtig HI, Siderowf A, Lee VM, Soares H, Trojanowski JQ. Novel CSF biomarkers for frontotemporal lobar degenerations. Neurology. 75: 2079-86. PMID 21048198 DOI: 10.1016/J.Jalz.2010.05.253  0.763
2010 Brunden KR, Zhang B, Carroll J, Yao Y, Potuzak JS, Hogan AM, Iba M, James MJ, Xie SX, Ballatore C, Smith AB, Lee VM, Trojanowski JQ. Epothilone D improves microtubule density, axonal integrity, and cognition in a transgenic mouse model of tauopathy. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 30: 13861-6. PMID 20943926 DOI: 10.1523/Jneurosci.3059-10.2010  0.451
2010 Geser F, Robinson JL, Malunda JA, Xie SX, Clark CM, Kwong LK, Moberg PJ, Moore EM, Van Deerlin VM, Lee VM, Arnold SE, Trojanowski JQ. Pathological 43-kDa transactivation response DNA-binding protein in older adults with and without severe mental illness. Archives of Neurology. 67: 1238-50. PMID 20937952 DOI: 10.1001/Archneurol.2010.254  0.386
2010 Hu WT, Wang Z, Lee VM, Trojanowski JQ, Detre JA, Grossman M. Distinct cerebral perfusion patterns in FTLD and AD. Neurology. 75: 881-8. PMID 20819999 DOI: 10.1212/Wnl.0B013E3181F11E35  0.639
2010 Hurtado DE, Molina-Porcel L, Iba M, Aboagye AK, Paul SM, Trojanowski JQ, Lee VM. A{beta} accelerates the spatiotemporal progression of tau pathology and augments tau amyloidosis in an Alzheimer mouse model. The American Journal of Pathology. 177: 1977-88. PMID 20802182 DOI: 10.2353/Ajpath.2010.100346  0.79
2010 Elden AC, Kim HJ, Hart MP, Chen-Plotkin AS, Johnson BS, Fang X, Armakola M, Geser F, Greene R, Lu MM, Padmanabhan A, Clay-Falcone D, McCluskey L, Elman L, Juhr D, ... ... Lee VM, et al. Ataxin-2 intermediate-length polyglutamine expansions are associated with increased risk for ALS. Nature. 466: 1069-75. PMID 20740007 DOI: 10.1038/Nature09320  0.619
2010 Hu WT, McMillan C, Libon D, Leight S, Forman M, Lee VM, Trojanowski JQ, Grossman M. Multimodal predictors for Alzheimer disease in nonfluent primary progressive aphasia. Neurology. 75: 595-602. PMID 20713948 DOI: 10.1212/Wnl.0B013E3181Ed9C52  0.818
2010 Hu WT, Chen-Plotkin A, Arnold SE, Grossman M, Clark CM, Shaw LM, McCluskey L, Elman L, Karlawish J, Hurtig HI, Siderowf A, Lee VM, Soares H, Trojanowski JQ. Biomarker discovery for Alzheimer's disease, frontotemporal lobar degeneration, and Parkinson's disease. Acta Neuropathologica. 120: 385-99. PMID 20652578 DOI: 10.1007/S00401-010-0723-9  0.773
2010 Korecka M, Clark CM, Lee VM, Trojanowski JQ, Shaw LM. Simultaneous HPLC-MS-MS quantification of 8-iso-PGF(2alpha) and 8,12-iso-iPF(2alpha) in CSF and brain tissue samples with on-line cleanup. Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences. 878: 2209-16. PMID 20643588 DOI: 10.1016/J.Jchromb.2010.06.029  0.307
2010 Ritson GP, Custer SK, Freibaum BD, Guinto JB, Geffel D, Moore J, Tang W, Winton MJ, Neumann M, Trojanowski JQ, Lee VM, Forman MS, Taylor JP. TDP-43 mediates degeneration in a novel Drosophila model of disease caused by mutations in VCP/p97. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 30: 7729-39. PMID 20519548 DOI: 10.1523/Jneurosci.5894-09.2010  0.752
2010 Trojanowski JQ, Vandeerstichele H, Korecka M, Clark CM, Aisen PS, Petersen RC, Blennow K, Soares H, Simon A, Lewczuk P, Dean R, Siemers E, Potter WZ, Weiner MW, Jack CR, ... ... Lee VM, et al. Update on the biomarker core of the Alzheimer's Disease Neuroimaging Initiative subjects. Alzheimer's & Dementia : the Journal of the Alzheimer's Association. 6: 230-8. PMID 20451871 DOI: 10.1016/J.Jalz.2010.03.008  0.427
2010 Arnold SE, Lee EB, Moberg PJ, Stutzbach L, Kazi H, Han LY, Lee VM, Trojanowski JQ. Olfactory epithelium amyloid-beta and paired helical filament-tau pathology in Alzheimer disease. Annals of Neurology. 67: 462-9. PMID 20437581 DOI: 10.1002/Ana.21910  0.672
2010 Garbern JY, Neumann M, Trojanowski JQ, Lee VM, Feldman G, Norris JW, Friez MJ, Schwartz CE, Stevenson R, Sima AA. A mutation affecting the sodium/proton exchanger, SLC9A6, causes mental retardation with tau deposition. Brain : a Journal of Neurology. 133: 1391-402. PMID 20395263 DOI: 10.1093/Brain/Awq071  0.427
2010 Ballatore C, Brunden KR, Piscitelli F, James MJ, Crowe A, Yao Y, Hyde E, Trojanowski JQ, Lee VM, Smith AB. Discovery of brain-penetrant, orally bioavailable aminothienopyridazine inhibitors of tau aggregation. Journal of Medicinal Chemistry. 53: 3739-47. PMID 20392114 DOI: 10.1021/Jm100138F  0.439
2010 Uryu K, Haddix T, Robinson J, Nakashima-Yasuda H, Lee VM, Trojanowski JQ. Burden of neurodegenerative diseases in a cohort of medical examiner subjects. Journal of Forensic Sciences. 55: 642-5. PMID 20345790 DOI: 10.1111/j.1556-4029.2010.01347.x  0.433
2010 Trojanowski JQ, Arnold SE, Karlawish JH, Brunden K, Cary M, Davatzikos C, Detre J, Gaulton G, Grossman M, Hurtig H, Jedrziewski K, McCluskey L, Naylor M, Polsky D, Schellenberg GD, ... ... Lee VM, et al. Design of comprehensive Alzheimer's disease centers to address unmet national needs. Alzheimer's & Dementia : the Journal of the Alzheimer's Association. 6: 150-5. PMID 20298979 DOI: 10.1016/J.Jalz.2009.11.004  0.523
2010 Xu S, Brunden KR, Trojanowski JQ, Lee VM. Characterization of tau fibrillization in vitro. Alzheimer's & Dementia : the Journal of the Alzheimer's Association. 6: 110-7. PMID 20298971 DOI: 10.1016/J.Jalz.2009.06.002  0.443
2010 Khachaturian ZS, Barnes D, Einstein R, Johnson S, Lee V, Roses A, Sager MA, Shankle WR, Snyder PJ, Petersen RC, Schellenberg G, Trojanowski J, Aisen P, Albert MS, Breitner JC, et al. Developing a national strategy to prevent dementia: Leon Thal Symposium 2009. Alzheimer's & Dementia : the Journal of the Alzheimer's Association. 6: 89-97. PMID 20298968 DOI: 10.1016/J.Jalz.2010.01.008  0.447
2010 Chen-Plotkin AS, Lee VM, Trojanowski JQ. TAR DNA-binding protein 43 in neurodegenerative disease. Nature Reviews. Neurology. 6: 211-20. PMID 20234357 DOI: 10.1038/Nrneurol.2010.18  0.681
2010 Hu WT, Chen-Plotkin A, Arnold SE, Grossman M, Clark CM, Shaw LM, Pickering E, Kuhn M, Chen Y, McCluskey L, Elman L, Karlawish J, Hurtig HI, Siderowf A, Lee VM, et al. Novel CSF biomarkers for Alzheimer's disease and mild cognitive impairment. Acta Neuropathologica. 119: 669-78. PMID 20232070 DOI: 10.1007/S00401-010-0667-0  0.756
2010 Kraemer BC, Schuck T, Wheeler JM, Robinson LC, Trojanowski JQ, Lee VM, Schellenberg GD. Loss of murine TDP-43 disrupts motor function and plays an essential role in embryogenesis. Acta Neuropathologica. 119: 409-19. PMID 20198480 DOI: 10.1007/S00401-010-0659-0  0.361
2010 Van Deerlin VM, Sleiman PM, Martinez-Lage M, Chen-Plotkin A, Wang LS, Graff-Radford NR, Dickson DW, Rademakers R, Boeve BF, Grossman M, Arnold SE, Mann DM, Pickering-Brown SM, Seelaar H, Heutink P, ... ... Lee VM, et al. Common variants at 7p21 are associated with frontotemporal lobar degeneration with TDP-43 inclusions. Nature Genetics. 42: 234-9. PMID 20154673 DOI: 10.1038/Ng.536  0.655
2010 Yu CE, Bird TD, Bekris LM, Montine TJ, Leverenz JB, Steinbart E, Galloway NM, Feldman H, Woltjer R, Miller CA, Wood EM, Grossman M, McCluskey L, Clark CM, Neumann M, ... ... Lee VM, et al. The spectrum of mutations in progranulin: a collaborative study screening 545 cases of neurodegeneration. Archives of Neurology. 67: 161-70. PMID 20142524 DOI: 10.1001/Archneurol.2009.328  0.66
2010 Geser F, Lee VM, Trojanowski JQ. Amyotrophic lateral sclerosis and frontotemporal lobar degeneration: a spectrum of TDP-43 proteinopathies. Neuropathology : Official Journal of the Japanese Society of Neuropathology. 30: 103-12. PMID 20102519 DOI: 10.1111/J.1440-1789.2009.01091.X  0.462
2010 Lim Y, Kehm VM, Li C, Trojanowski JQ, Lee VM. Forebrain overexpression of alpha-synuclein leads to early postnatal hippocampal neuron loss and synaptic disruption. Experimental Neurology. 221: 86-97. PMID 19833127 DOI: 10.1016/J.Expneurol.2009.10.005  0.769
2010 Brunden KR, Ballatore C, Crowe A, Smith AB, Lee VM, Trojanowski JQ. Tau-directed drug discovery for Alzheimer's disease and related tauopathies: a focus on tau assembly inhibitors. Experimental Neurology. 223: 304-10. PMID 19744482 DOI: 10.1016/J.Expneurol.2009.08.031  0.472
2010 Chen-Plotkin AS, Xiao J, Geser F, Martinez-Lage M, Grossman M, Unger T, Wood EM, Van Deerlin VM, Trojanowski JQ, Lee VM. Brain progranulin expression in GRN-associated frontotemporal lobar degeneration. Acta Neuropathologica. 119: 111-22. PMID 19649643 DOI: 10.1007/S00401-009-0576-2  0.677
2010 Lee V. Tau focused drug discovery for Alzheimer's disease and related tauopathies Alzheimers & Dementia. 6. DOI: 10.1016/J.Jalz.2010.05.462  0.386
2009 Lippa CF, Rosso AL, Stutzbach LD, Neumann M, Lee VM, Trojanowski JQ. Transactive response DNA-binding protein 43 burden in familial Alzheimer disease and Down syndrome. Archives of Neurology. 66: 1483-8. PMID 20008652 DOI: 10.1001/Archneurol.2009.277  0.452
2009 Portelius E, Zhang B, Gustavsson MK, Brinkmalm G, Westman-Brinkmalm A, Zetterberg H, Lee VM, Trojanowski JQ, Blennow K. Effects of gamma-secretase inhibition on the amyloid beta isoform pattern in a mouse model of Alzheimer's disease. Neuro-Degenerative Diseases. 6: 258-62. PMID 19955704 DOI: 10.1159/000264639  0.396
2009 Hu WT, Seelaar H, Josephs KA, Knopman DS, Boeve BF, Sorenson EJ, McCluskey L, Elman L, Schelhaas HJ, Parisi JE, Kuesters B, Lee VM, Trojanowski JQ, Petersen RC, van Swieten JC, et al. Survival profiles of patients with frontotemporal dementia and motor neuron disease. Archives of Neurology. 66: 1359-64. PMID 19901167 DOI: 10.1001/Archneurol.2009.253  0.77
2009 Luk KC, Song C, O'Brien P, Stieber A, Branch JR, Brunden KR, Trojanowski JQ, Lee VM. Exogenous alpha-synuclein fibrils seed the formation of Lewy body-like intracellular inclusions in cultured cells. Proceedings of the National Academy of Sciences of the United States of America. 106: 20051-6. PMID 19892735 DOI: 10.1073/Pnas.0908005106  0.375
2009 Pesiridis GS, Lee VM, Trojanowski JQ. Mutations in TDP-43 link glycine-rich domain functions to amyotrophic lateral sclerosis. Human Molecular Genetics. 18: R156-62. PMID 19808791 DOI: 10.1093/Hmg/Ddp303  0.38
2009 Brunden KR, Trojanowski JQ, Lee VM. Advances in tau-focused drug discovery for Alzheimer's disease and related tauopathies. Nature Reviews. Drug Discovery. 8: 783-93. PMID 19794442 DOI: 10.1038/Nrd2959  0.486
2009 Crowe A, Huang W, Ballatore C, Johnson RL, Hogan AM, Huang R, Wichterman J, McCoy J, Huryn D, Auld DS, Smith AB, Inglese J, Trojanowski JQ, Austin CP, Brunden KR, ... Lee VM, et al. Identification of aminothienopyridazine inhibitors of tau assembly by quantitative high-throughput screening. Biochemistry. 48: 7732-45. PMID 19580328 DOI: 10.1021/Bi9006435  0.453
2009 Li W, Sperry JB, Crowe A, Trojanowski JQ, Smith AB, Lee VM. Inhibition of tau fibrillization by oleocanthal via reaction with the amino groups of tau. Journal of Neurochemistry. 110: 1339-51. PMID 19549281 DOI: 10.1111/J.1471-4159.2009.06224.X  0.596
2009 Khachaturian ZS, Snyder PJ, Doody R, Aisen P, Comer M, Dwyer J, Frank RA, Holzapfel A, Khachaturian AS, Korczyn AD, Roses A, Simpkins JW, Schneider LS, Albert MS, Egge R, ... ... Lee V, et al. A roadmap for the prevention of dementia II: Leon Thal Symposium 2008. Alzheimer's & Dementia : the Journal of the Alzheimer's Association. 5: 85-92. PMID 19328434 DOI: 10.1016/j.jalz.2009.01.021  0.358
2009 Shaw LM, Vanderstichele H, Knapik-Czajka M, Clark CM, Aisen PS, Petersen RC, Blennow K, Soares H, Simon A, Lewczuk P, Dean R, Siemers E, Potter W, Lee VM, Trojanowski JQ, et al. Cerebrospinal fluid biomarker signature in Alzheimer's disease neuroimaging initiative subjects. Annals of Neurology. 65: 403-13. PMID 19296504 DOI: 10.1002/Ana.21610  0.413
2009 Geser F, Martinez-Lage M, Kwong LK, Lee VM, Trojanowski JQ. Amyotrophic lateral sclerosis, frontotemporal dementia and beyond: the TDP-43 diseases. Journal of Neurology. 256: 1205-14. PMID 19271105 DOI: 10.1007/S00415-009-5069-7  0.461
2009 Shineman DW, Dain AS, Kim ML, Lee VM. Constitutively active Akt inhibits trafficking of amyloid precursor protein and amyloid precursor protein metabolites through feedback inhibition of phosphoinositide 3-kinase. Biochemistry. 48: 3787-94. PMID 19236051 DOI: 10.1021/Bi802070J  0.761
2009 Koffie RM, Meyer-Luehmann M, Hashimoto T, Adams KW, Mielke ML, Garcia-Alloza M, Micheva KD, Smith SJ, Kim ML, Lee VM, Hyman BT, Spires-Jones TL. Oligomeric amyloid beta associates with postsynaptic densities and correlates with excitatory synapse loss near senile plaques. Proceedings of the National Academy of Sciences of the United States of America. 106: 4012-7. PMID 19228947 DOI: 10.1073/Pnas.0811698106  0.586
2009 Geser F, Martinez-Lage M, Robinson J, Uryu K, Neumann M, Brandmeir NJ, Xie SX, Kwong LK, Elman L, McCluskey L, Clark CM, Malunda J, Miller BL, Zimmerman EA, Qian J, ... ... Lee VM, et al. Clinical and pathological continuum of multisystem TDP-43 proteinopathies. Archives of Neurology. 66: 180-9. PMID 19204154 DOI: 10.1001/Archneurol.2008.558  0.539
2009 Igaz LM, Kwong LK, Chen-Plotkin A, Winton MJ, Unger TL, Xu Y, Neumann M, Trojanowski JQ, Lee VM. Expression of TDP-43 C-terminal Fragments in Vitro Recapitulates Pathological Features of TDP-43 Proteinopathies. The Journal of Biological Chemistry. 284: 8516-24. PMID 19164285 DOI: 10.1074/Jbc.M809462200  0.817
2009 Neumann M, Kwong LK, Lee EB, Kremmer E, Flatley A, Xu Y, Forman MS, Troost D, Kretzschmar HA, Trojanowski JQ, Lee VM. Phosphorylation of S409/410 of TDP-43 is a consistent feature in all sporadic and familial forms of TDP-43 proteinopathies. Acta Neuropathologica. 117: 137-49. PMID 19125255 DOI: 10.1007/S00401-008-0477-9  0.809
2008 Ji B, Maeda J, Sawada M, Ono M, Okauchi T, Inaji M, Zhang MR, Suzuki K, Ando K, Staufenbiel M, Trojanowski JQ, Lee VM, Higuchi M, Suhara T. Imaging of peripheral benzodiazepine receptor expression as biomarkers of detrimental versus beneficial glial responses in mouse models of Alzheimer's and other CNS pathologies. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 28: 12255-67. PMID 19020019 DOI: 10.1523/Jneurosci.2312-08.2008  0.461
2008 Kim ML, Zhang B, Mills IP, Milla ME, Brunden KR, Lee VM. Effects of TNFalpha-converting enzyme inhibition on amyloid beta production and APP processing in vitro and in vivo. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 28: 12052-61. PMID 19005070 DOI: 10.1523/Jneurosci.2913-08.2008  0.552
2008 Steinacker P, Hendrich C, Sperfeld AD, Jesse S, von Arnim CA, Lehnert S, Pabst A, Uttner I, Tumani H, Lee VM, Trojanowski JQ, Kretzschmar HA, Ludolph A, Neumann M, Otto M. TDP-43 in cerebrospinal fluid of patients with frontotemporal lobar degeneration and amyotrophic lateral sclerosis. Archives of Neurology. 65: 1481-7. PMID 19001167 DOI: 10.1001/Archneur.65.11.1481  0.364
2008 Luk KC, Mills IP, Trojanowski JQ, Lee VM. Interactions between Hsp70 and the hydrophobic core of alpha-synuclein inhibit fibril assembly. Biochemistry. 47: 12614-25. PMID 18975920 DOI: 10.1021/Bi801475R  0.387
2008 Ballatore C, Zhang B, Trojanowski JQ, Lee VM, Smith AB. In situ blood-brain barrier permeability of a C-10 paclitaxel carbamate. Bioorganic & Medicinal Chemistry Letters. 18: 6119-21. PMID 18947993 DOI: 10.1016/J.Bmcl.2008.10.024  0.305
2008 Kühnlein P, Sperfeld AD, Vanmassenhove B, Van Deerlin V, Lee VM, Trojanowski JQ, Kretzschmar HA, Ludolph AC, Neumann M. Two German kindreds with familial amyotrophic lateral sclerosis due to TARDBP mutations. Archives of Neurology. 65: 1185-9. PMID 18779421 DOI: 10.1001/Archneur.65.9.1185  0.337
2008 Brunden KR, Trojanowski JQ, Lee VM. Evidence that non-fibrillar tau causes pathology linked to neurodegeneration and behavioral impairments. Journal of Alzheimer's Disease : Jad. 14: 393-9. PMID 18688089 DOI: 10.3233/Jad-2008-14406  0.494
2008 Gao HM, Kotzbauer PT, Uryu K, Leight S, Trojanowski JQ, Lee VM. Neuroinflammation and oxidation/nitration of alpha-synuclein linked to dopaminergic neurodegeneration. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 28: 7687-98. PMID 18650345 DOI: 10.1523/Jneurosci.0143-07.2008  0.378
2008 Cheung KH, Shineman D, Müller M, Cárdenas C, Mei L, Yang J, Tomita T, Iwatsubo T, Lee VM, Foskett JK. Mechanism of Ca2+ disruption in Alzheimer's disease by presenilin regulation of InsP3 receptor channel gating. Neuron. 58: 871-83. PMID 18579078 DOI: 10.1016/J.Neuron.2008.04.015  0.692
2008 Igaz LM, Kwong LK, Xu Y, Truax AC, Uryu K, Neumann M, Clark CM, Elman LB, Miller BL, Grossman M, McCluskey LF, Trojanowski JQ, Lee VM. Enrichment of C-terminal fragments in TAR DNA-binding protein-43 cytoplasmic inclusions in brain but not in spinal cord of frontotemporal lobar degeneration and amyotrophic lateral sclerosis. The American Journal of Pathology. 173: 182-94. PMID 18535185 DOI: 10.2353/Ajpath.2008.080003  0.793
2008 Uryu K, Nakashima-Yasuda H, Forman MS, Kwong LK, Clark CM, Grossman M, Miller BL, Kretzschmar HA, Lee VM, Trojanowski JQ, Neumann M. Concomitant TAR-DNA-binding protein 43 pathology is present in Alzheimer disease and corticobasal degeneration but not in other tauopathies. Journal of Neuropathology and Experimental Neurology. 67: 555-64. PMID 18520774 DOI: 10.1097/Nen.0B013E31817713B5  0.802
2008 Winton MJ, Van Deerlin VM, Kwong LK, Yuan W, Wood EM, Yu CE, Schellenberg GD, Rademakers R, Caselli R, Karydas A, Trojanowski JQ, Miller BL, Lee VM. A90V TDP-43 variant results in the aberrant localization of TDP-43 in vitro. Febs Letters. 582: 2252-6. PMID 18505686 DOI: 10.1016/J.Febslet.2008.05.024  0.401
2008 Roy S, Winton MJ, Black MM, Trojanowski JQ, Lee VM. Cytoskeletal requirements in axonal transport of slow component-b. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 28: 5248-56. PMID 18480281 DOI: 10.1523/Jneurosci.0309-08.2008  0.709
2008 Geser F, Brandmeir NJ, Kwong LK, Martinez-Lage M, Elman L, McCluskey L, Xie SX, Lee VM, Trojanowski JQ. Evidence of multisystem disorder in whole-brain map of pathological TDP-43 in amyotrophic lateral sclerosis. Archives of Neurology. 65: 636-41. PMID 18474740 DOI: 10.1001/Archneur.65.5.636  0.41
2008 Bian H, Van Swieten JC, Leight S, Massimo L, Wood E, Forman M, Moore P, de Koning I, Clark CM, Rosso S, Trojanowski J, Lee VM, Grossman M. CSF biomarkers in frontotemporal lobar degeneration with known pathology. Neurology. 70: 1827-35. PMID 18458217 DOI: 10.1212/01.Wnl.0000311445.21321.Fc  0.763
2008 Shineman DW, Zhang B, Leight SN, Pratico D, Lee VM. Thromboxane receptor activation mediates isoprostane-induced increases in amyloid pathology in Tg2576 mice. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 28: 4785-94. PMID 18448655 DOI: 10.1523/Jneurosci.0684-08.2008  0.736
2008 Lim J, Balastik M, Lee TH, Nakamura K, Liou YC, Sun A, Finn G, Pastorino L, Lee VM, Lu KP. Pin1 has opposite effects on wild-type and P301L tau stability and tauopathy. The Journal of Clinical Investigation. 118: 1877-89. PMID 18431510 DOI: 10.1172/Jci34308  0.323
2008 Grossman M, Xie SX, Libon DJ, Wang X, Massimo L, Moore P, Vesely L, Berkowitz R, Chatterjee A, Coslett HB, Hurtig HI, Forman MS, Lee VM, Trojanowski JQ. Longitudinal decline in autopsy-defined frontotemporal lobar degeneration. Neurology. 70: 2036-45. PMID 18420483 DOI: 10.1212/01.Wnl.0000303816.25065.Bc  0.765
2008 Van Deerlin VM, Leverenz JB, Bekris LM, Bird TD, Yuan W, Elman LB, Clay D, Wood EM, Chen-Plotkin AS, Martinez-Lage M, Steinbart E, McCluskey L, Grossman M, Neumann M, Wu IL, ... ... Lee VM, et al. TARDBP mutations in amyotrophic lateral sclerosis with TDP-43 neuropathology: a genetic and histopathological analysis. The Lancet. Neurology. 7: 409-16. PMID 18396105 DOI: 10.1016/S1474-4422(08)70071-1  0.672
2008 Winton MJ, Igaz LM, Wong MM, Kwong LK, Trojanowski JQ, Lee VM. Disturbance of nuclear and cytoplasmic TAR DNA-binding protein (TDP-43) induces disease-like redistribution, sequestration, and aggregate formation. The Journal of Biological Chemistry. 283: 13302-9. PMID 18305110 DOI: 10.1074/Jbc.M800342200  0.793
2008 Chen-Plotkin AS, Geser F, Plotkin JB, Clark CM, Kwong LK, Yuan W, Grossman M, Van Deerlin VM, Trojanowski JQ, Lee VM. Variations in the progranulin gene affect global gene expression in frontotemporal lobar degeneration. Human Molecular Genetics. 17: 1349-62. PMID 18223198 DOI: 10.1093/Hmg/Ddn023  0.689
2008 Soper JH, Roy S, Stieber A, Lee E, Wilson RB, Trojanowski JQ, Burd CG, Lee VM. Alpha-synuclein-induced aggregation of cytoplasmic vesicles in Saccharomyces cerevisiae. Molecular Biology of the Cell. 19: 1093-103. PMID 18172022 DOI: 10.1091/Mbc.E07-08-0827  0.801
2008 Kwong LK, Uryu K, Trojanowski JQ, Lee VM. TDP-43 proteinopathies: neurodegenerative protein misfolding diseases without amyloidosis. Neuro-Signals. 16: 41-51. PMID 18097159 DOI: 10.1159/000109758  0.45
2008 Clark CM, Davatzikos C, Borthakur A, Newberg A, Leight S, Lee VM, Trojanowski JQ. Biomarkers for early detection of Alzheimer pathology. Neuro-Signals. 16: 11-8. PMID 18097155 DOI: 10.1159/000109754  0.455
2008 Lee EB, Lee VM, Trojanowski JQ, Neumann M. TDP-43 immunoreactivity in anoxic, ischemic and neoplastic lesions of the central nervous system. Acta Neuropathologica. 115: 305-11. PMID 18087705 DOI: 10.1007/S00401-007-0331-5  0.647
2008 Brandmeir NJ, Geser F, Kwong LK, Zimmerman E, Qian J, Lee VM, Trojanowski JQ. Severe subcortical TDP-43 pathology in sporadic frontotemporal lobar degeneration with motor neuron disease. Acta Neuropathologica. 115: 123-31. PMID 18004574 DOI: 10.1007/S00401-007-0315-5  0.455
2008 Chen-Plotkin AS, Yuan W, Anderson C, McCarty Wood E, Hurtig HI, Clark CM, Miller BL, Lee VM, Trojanowski JQ, Grossman M, Van Deerlin VM. Corticobasal syndrome and primary progressive aphasia as manifestations of LRRK2 gene mutations. Neurology. 70: 521-7. PMID 17914064 DOI: 10.1212/01.Wnl.0000280574.17166.26  0.662
2008 Geser F, Winton MJ, Kwong LK, Xu Y, Xie SX, Igaz LM, Garruto RM, Perl DP, Galasko D, Lee VM, Trojanowski JQ. Pathological TDP-43 in parkinsonism-dementia complex and amyotrophic lateral sclerosis of Guam. Acta Neuropathologica. 115: 133-45. PMID 17713769 DOI: 10.1007/S00401-007-0257-Y  0.786
2008 Xie SX, Forman MS, Farmer J, Moore P, Wang Y, Wang X, Clark CM, Coslett HB, Chatterjee A, Arnold SE, Rosen H, Karlawish JH, Van Deerlin VM, Lee VM, Trojanowski JQ, et al. Factors associated with survival probability in autopsy-proven frontotemporal lobar degeneration. Journal of Neurology, Neurosurgery, and Psychiatry. 79: 126-9. PMID 17615171 DOI: 10.1136/Jnnp.2006.110288  0.782
2008 Lee V. S3-03-05: Tau focused drug discovery for Alzheimer's disease and related tauopathies Alzheimers & Dementia. 4. DOI: 10.1016/J.Jalz.2008.05.389  0.372
2007 Grossman M, Libon DJ, Forman MS, Massimo L, Wood E, Moore P, Anderson C, Farmer J, Chatterjee A, Clark CM, Coslett HB, Hurtig HI, Lee VM, Trojanowski JQ. Distinct antemortem profiles in patients with pathologically defined frontotemporal dementia. Archives of Neurology. 64: 1601-9. PMID 17998442 DOI: 10.1001/Archneur.64.11.1601  0.784
2007 Forman MS, Trojanowski JQ, Lee VM. TDP-43: a novel neurodegenerative proteinopathy. Current Opinion in Neurobiology. 17: 548-55. PMID 17936612 DOI: 10.1016/J.Conb.2007.08.005  0.782
2007 Luk KC, Hyde EG, Trojanowski JQ, Lee VM. Sensitive fluorescence polarization technique for rapid screening of alpha-synuclein oligomerization/fibrillization inhibitors. Biochemistry. 46: 12522-9. PMID 17927212 DOI: 10.1021/Bi701128C  0.398
2007 Grossman M, Wood EM, Moore P, Neumann M, Kwong L, Forman MS, Clark CM, McCluskey LF, Miller BL, Lee VM, Trojanowski JQ. TDP-43 pathologic lesions and clinical phenotype in frontotemporal lobar degeneration with ubiquitin-positive inclusions. Archives of Neurology. 64: 1449-54. PMID 17923628 DOI: 10.1001/Archneur.64.10.1449  0.781
2007 Neumann M, Kwong LK, Sampathu DM, Trojanowski JQ, Lee VM. TDP-43 proteinopathy in frontotemporal lobar degeneration and amyotrophic lateral sclerosis: protein misfolding diseases without amyloidosis. Archives of Neurology. 64: 1388-94. PMID 17923623 DOI: 10.1001/Archneur.64.10.1388  0.83
2007 Uryu K, Chen XH, Martinez D, Browne KD, Johnson VE, Graham DI, Lee VM, Trojanowski JQ, Smith DH. Multiple proteins implicated in neurodegenerative diseases accumulate in axons after brain trauma in humans. Experimental Neurology. 208: 185-92. PMID 17826768 DOI: 10.1016/J.Expneurol.2007.06.018  0.41
2007 Van Deerlin VM, Wood EM, Moore P, Yuan W, Forman MS, Clark CM, Neumann M, Kwong LK, Trojanowski JQ, Lee VM, Grossman M. Clinical, genetic, and pathologic characteristics of patients with frontotemporal dementia and progranulin mutations. Archives of Neurology. 64: 1148-53. PMID 17698705 DOI: 10.1001/Archneur.64.8.1148  0.756
2007 Ballatore C, Lee VM, Trojanowski JQ. Tau-mediated neurodegeneration in Alzheimer's disease and related disorders. Nature Reviews. Neuroscience. 8: 663-72. PMID 17684513 DOI: 10.1038/Nrn2194  0.487
2007 Nakashima-Yasuda H, Uryu K, Robinson J, Xie SX, Hurtig H, Duda JE, Arnold SE, Siderowf A, Grossman M, Leverenz JB, Woltjer R, Lopez OL, Hamilton R, Tsuang DW, Galasko D, ... ... Lee VM, et al. Co-morbidity of TDP-43 proteinopathy in Lewy body related diseases. Acta Neuropathologica. 114: 221-9. PMID 17653732 DOI: 10.1007/S00401-007-0261-2  0.602
2007 Cairns NJ, Neumann M, Bigio EH, Holm IE, Troost D, Hatanpaa KJ, Foong C, White CL, Schneider JA, Kretzschmar HA, Carter D, Taylor-Reinwald L, Paulsmeyer K, Strider J, Gitcho M, ... ... Lee VM, et al. TDP-43 in familial and sporadic frontotemporal lobar degeneration with ubiquitin inclusions. The American Journal of Pathology. 171: 227-40. PMID 17591968 DOI: 10.2353/Ajpath.2007.070182  0.751
2007 Cairns NJ, Bigio EH, Mackenzie IR, Neumann M, Lee VM, Hatanpaa KJ, White CL, Schneider JA, Grinberg LT, Halliday G, Duyckaerts C, Lowe JS, Holm IE, Tolnay M, Okamoto K, et al. Neuropathologic diagnostic and nosologic criteria for frontotemporal lobar degeneration: consensus of the Consortium for Frontotemporal Lobar Degeneration. Acta Neuropathologica. 114: 5-22. PMID 17579875 DOI: 10.1007/S00401-007-0237-2  0.452
2007 Kwong LK, Neumann M, Sampathu DM, Lee VM, Trojanowski JQ. TDP-43 proteinopathy: the neuropathology underlying major forms of sporadic and familial frontotemporal lobar degeneration and motor neuron disease. Acta Neuropathologica. 114: 63-70. PMID 17492294 DOI: 10.1007/S00401-007-0226-5  0.815
2007 Crowe A, Ballatore C, Hyde E, Trojanowski JQ, Lee VM. High throughput screening for small molecule inhibitors of heparin-induced tau fibril formation. Biochemical and Biophysical Research Communications. 358: 1-6. PMID 17482143 DOI: 10.1016/J.Bbrc.2007.03.056  0.359
2007 Mackenzie IR, Bigio EH, Ince PG, Geser F, Neumann M, Cairns NJ, Kwong LK, Forman MS, Ravits J, Stewart H, Eisen A, McClusky L, Kretzschmar HA, Monoranu CM, Highley JR, ... ... Lee VM, et al. Pathological TDP-43 distinguishes sporadic amyotrophic lateral sclerosis from amyotrophic lateral sclerosis with SOD1 mutations. Annals of Neurology. 61: 427-34. PMID 17469116 DOI: 10.1002/Ana.21147  0.735
2007 Murray R, Neumann M, Forman MS, Farmer J, Massimo L, Rice A, Miller BL, Johnson JK, Clark CM, Hurtig HI, Gorno-Tempini ML, Lee VM, Trojanowski JQ, Grossman M. Cognitive and motor assessment in autopsy-proven corticobasal degeneration. Neurology. 68: 1274-83. PMID 17438218 DOI: 10.1212/01.Wnl.0000259519.78480.C3  0.76
2007 Neumann M, Igaz LM, Kwong LK, Nakashima-Yasuda H, Kolb SJ, Dreyfuss G, Kretzschmar HA, Trojanowski JQ, Lee VM. Absence of heterogeneous nuclear ribonucleoproteins and survival motor neuron protein in TDP-43 positive inclusions in frontotemporal lobar degeneration. Acta Neuropathologica. 113: 543-8. PMID 17415574 DOI: 10.1007/S00401-007-0221-X  0.791
2007 Roy S, Winton MJ, Black MM, Trojanowski JQ, Lee VM. Rapid and intermittent cotransport of slow component-b proteins. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 27: 3131-8. PMID 17376974 DOI: 10.1523/Jneurosci.4999-06.2007  0.723
2007 Neumann M, Kwong LK, Truax AC, Vanmassenhove B, Kretzschmar HA, Van Deerlin VM, Clark CM, Grossman M, Miller BL, Trojanowski JQ, Lee VM. TDP-43-positive white matter pathology in frontotemporal lobar degeneration with ubiquitin-positive inclusions. Journal of Neuropathology and Experimental Neurology. 66: 177-83. PMID 17356379 DOI: 10.1097/01.Jnen.0000248554.45456.58  0.542
2007 Lippa CF, Duda JE, Grossman M, Hurtig HI, Aarsland D, Boeve BF, Brooks DJ, Dickson DW, Dubois B, Emre M, Fahn S, Farmer JM, Galasko D, Galvin JE, Goetz CG, ... ... Lee VM, et al. DLB and PDD boundary issues: diagnosis, treatment, molecular pathology, and biomarkers. Neurology. 68: 812-9. PMID 17353469 DOI: 10.1212/01.Wnl.0000256715.13907.D3  0.555
2007 Shaw LM, Korecka M, Clark CM, Lee VM, Trojanowski JQ. Biomarkers of neurodegeneration for diagnosis and monitoring therapeutics. Nature Reviews. Drug Discovery. 6: 295-303. PMID 17347655 DOI: 10.1038/Nrd2176  0.397
2007 Forman MS, Mufson EJ, Leurgans S, Pratico D, Joyce S, Leight S, Lee VM, Trojanowski JQ. Cortical biochemistry in MCI and Alzheimer disease: lack of correlation with clinical diagnosis. Neurology. 68: 757-63. PMID 17339583 DOI: 10.1212/01.Wnl.0000256373.39415.B1  0.776
2007 Brito C, Escrevente C, Reis CA, Lee VM, Trojanowski JQ, Costa J. Increased levels of fucosyltransferase IX and carbohydrate Lewis(x) adhesion determinant in human NT2N neurons. Journal of Neuroscience Research. 85: 1260-70. PMID 17335083 DOI: 10.1002/Jnr.21230  0.333
2007 Yoshiyama Y, Higuchi M, Zhang B, Huang SM, Iwata N, Saido TC, Maeda J, Suhara T, Trojanowski JQ, Lee VM. Synapse loss and microglial activation precede tangles in a P301S tauopathy mouse model. Neuron. 53: 337-51. PMID 17270732 DOI: 10.1016/J.Neuron.2007.01.010  0.448
2007 Norris EH, Uryu K, Leight S, Giasson BI, Trojanowski JQ, Lee VM. Pesticide exposure exacerbates alpha-synucleinopathy in an A53T transgenic mouse model. The American Journal of Pathology. 170: 658-66. PMID 17255333 DOI: 10.2353/Ajpath.2007.060359  0.754
2007 Van Deerlin VM, Forman MS, Farmer JM, Grossman M, Joyce S, Crowe A, Trojanowski JQ, Lee VM, Chatterjee A. Biochemical and pathological characterization of frontotemporal dementia due to a Leu266Val mutation in microtubule-associated protein tau in an African American individual. Acta Neuropathologica. 113: 471-9. PMID 17072625 DOI: 10.1007/S00401-006-0155-8  0.79
2007 Riedel M, Goldbaum O, Uryu K, Bruce J, Trojanowski JQ, Lee VM, Richter-Landsberg C. Alpha-Synuclein aggregate formation in oligodendroglia OLN-t40 cells stably transfected with alpha-Synuclein Bmc Neuroscience. 8. DOI: 10.1186/1471-2202-8-S1-P13  0.337
2007 Roy S, Winton MJ, Black MM, Trojanowski JQ, Lee VM. Mechanisms of slow axonal transport of α-synuclein Journal of Neuropathology and Experimental Neurology. 66: 429. DOI: 10.1097/01.Jnen.0000268848.12854.D7  0.708
2007 Roy S, Winton MJ, Black MM, Trojanowski JQ, Lee VM. Mechanisms of slow axonal transport of α‐synuclein The Faseb Journal. 21. DOI: 10.1096/Fasebj.21.5.A28-D  0.698
2007 Shaw LM, Vanderstichele H, Knapik-Czajka M, Blennow K, Soares H, Simon A, Lewczuk P, Siemers E, Dean R, Raha N, Chappell DL, Wiltfang J, Lachno R, Salfen BE, Lee VM, et al. P-057: Validation of the xMAP technology and performance of INNO-BIA AlzBio3 for quantification in CSF of Aβ1-42 , total tau and P-tau181p Alzheimer's & Dementia. 3: S117-S117. DOI: 10.1016/J.Jalz.2007.04.310  0.43
2006 Beal MF, Bossy-Wetzel E, Finkbeiner S, Fiskum G, Giasson B, Johnson C, Khachaturian ZS, Lee VM, Nicholls D, Reddy H, Reynolds I, Teplow DB, Thal LJ, Trojanowski JQ, Walsh DM, et al. Common threads in neurodegenerative disorders of aging. Alzheimer's & Dementia : the Journal of the Alzheimer's Association. 2: 322-6. PMID 19595906 DOI: 10.1016/J.Jalz.2006.08.008  0.64
2006 Clark CM, Pratico D, Shaw LM, Leight S, Xie SX, Gu A, Lee VM, Trojanowski JQ. Commentary on "Optimal design of clinical trials for drugs designed to slow the course of Alzheimer's disease." Biochemical biomarkers of late-life dementia. Alzheimer's & Dementia : the Journal of the Alzheimer's Association. 2: 287-93. PMID 19595902 DOI: 10.1016/J.Jalz.2006.05.2347  0.463
2006 Skovronsky DM, Lee VM, Trojanowski JQ. Neurodegenerative diseases: new concepts of pathogenesis and their therapeutic implications. Annual Review of Pathology. 1: 151-70. PMID 18039111 DOI: 10.1146/Annurev.Pathol.1.110304.100113  0.79
2006 Riekse RG, Li G, Petrie EC, Leverenz JB, Vavrek D, Vuletic S, Albers JJ, Montine TJ, Lee VM, Lee M, Seubert P, Galasko D, Schellenberg GD, Hazzard WR, Peskind ER. Effect of statins on Alzheimer's disease biomarkers in cerebrospinal fluid. Journal of Alzheimer's Disease : Jad. 10: 399-406. PMID 17183151 DOI: 10.3233/Jad-2006-10408  0.307
2006 Li W, Lee VM. Characterization of two VQIXXK motifs for tau fibrillization in vitro. Biochemistry. 45: 15692-701. PMID 17176091 DOI: 10.1021/Bi061422+  0.521
2006 Borthakur A, Gur T, Wheaton AJ, Corbo M, Trojanowski JQ, Lee VM, Reddy R. In vivo measurement of plaque burden in a mouse model of Alzheimer's disease. Journal of Magnetic Resonance Imaging : Jmri. 24: 1011-7. PMID 17036339 DOI: 10.1002/Jmri.20751  0.45
2006 Neumann M, Sampathu DM, Kwong LK, Truax AC, Micsenyi MC, Chou TT, Bruce J, Schuck T, Grossman M, Clark CM, McCluskey LF, Miller BL, Masliah E, Mackenzie IR, Feldman H, ... ... Lee VM, et al. Ubiquitinated TDP-43 in frontotemporal lobar degeneration and amyotrophic lateral sclerosis. Science (New York, N.Y.). 314: 130-3. PMID 17023659 DOI: 10.1126/Science.1134108  0.816
2006 Lee VM, Trojanowski JQ. Mechanisms of Parkinson's disease linked to pathological alpha-synuclein: new targets for drug discovery. Neuron. 52: 33-8. PMID 17015225 DOI: 10.1016/J.Neuron.2006.09.026  0.406
2006 Sampathu DM, Neumann M, Kwong LK, Chou TT, Micsenyi M, Truax A, Bruce J, Grossman M, Trojanowski JQ, Lee VM. Pathological heterogeneity of frontotemporal lobar degeneration with ubiquitin-positive inclusions delineated by ubiquitin immunohistochemistry and novel monoclonal antibodies. The American Journal of Pathology. 169: 1343-52. PMID 17003490 DOI: 10.2353/Ajpath.2006.060438  0.815
2006 Fan Y, Limprasert P, Murray IV, Smith AC, Lee VM, Trojanowski JQ, Sopher BL, La Spada AR. Beta-synuclein modulates alpha-synuclein neurotoxicity by reducing alpha-synuclein protein expression. Human Molecular Genetics. 15: 3002-11. PMID 16959793 DOI: 10.1093/Hmg/Ddl242  0.693
2006 Lee VM, Trojanowski JQ. Progress from Alzheimer's tangles to pathological tau points towards more effective therapies now. Journal of Alzheimer's Disease : Jad. 9: 257-62. PMID 16914864 DOI: 10.3233/Jad-2006-9S328  0.444
2006 Liu K, Solano I, Mann D, Lemere C, Mercken M, Trojanowski JQ, Lee VM. Characterization of Abeta11-40/42 peptide deposition in Alzheimer's disease and young Down's syndrome brains: implication of N-terminally truncated Abeta species in the pathogenesis of Alzheimer's disease. Acta Neuropathologica. 112: 163-74. PMID 16865398 DOI: 10.1007/S00401-006-0077-5  0.586
2006 Zhukareva V, Joyce S, Schuck T, Van Deerlin V, Hurtig H, Albin R, Gilman S, Chin S, Miller B, Trojanowski JQ, Lee VM. Unexpected abundance of pathological tau in progressive supranuclear palsy white matter. Annals of Neurology. 60: 335-45. PMID 16823854 DOI: 10.1002/Ana.20916  0.424
2006 Goker-Alpan O, Giasson BI, Eblan MJ, Nguyen J, Hurtig HI, Lee VM, Trojanowski JQ, Sidransky E. Glucocerebrosidase mutations are an important risk factor for Lewy body disorders. Neurology. 67: 908-10. PMID 16790605 DOI: 10.1212/01.Wnl.0000230215.41296.18  0.615
2006 Forman MS, Farmer J, Johnson JK, Clark CM, Arnold SE, Coslett HB, Chatterjee A, Hurtig HI, Karlawish JH, Rosen HJ, Van Deerlin V, Lee VM, Miller BL, Trojanowski JQ, Grossman M. Frontotemporal dementia: clinicopathological correlations. Annals of Neurology. 59: 952-62. PMID 16718704 DOI: 10.1002/Ana.20873  0.792
2006 Winton MJ, Joyce S, Zhukareva V, Practico D, Perl DP, Galasko D, Craig U, Trojanowski JQ, Lee VM. Characterization of tau pathologies in gray and white matter of Guam parkinsonism-dementia complex. Acta Neuropathologica. 111: 401-12. PMID 16609851 DOI: 10.1007/S00401-006-0053-0  0.498
2006 Uryu K, Richter-Landsberg C, Welch W, Sun E, Goldbaum O, Norris EH, Pham CT, Yazawa I, Hilburger K, Micsenyi M, Giasson BI, Bonini NM, Lee VM, Trojanowski JQ. Convergence of heat shock protein 90 with ubiquitin in filamentous alpha-synuclein inclusions of alpha-synucleinopathies. The American Journal of Pathology. 168: 947-61. PMID 16507910 DOI: 10.2353/Ajpath.2006.050770  0.75
2006 Liang TW, Truax AC, Trojanowski JQ, Lee VM, Stern MB, Kotzbauer PT. Partial deficit of pantothenate kinase 2 catalytic activity in a case of tremor-predominant neurodegeneration with brain iron accumulation. Movement Disorders : Official Journal of the Movement Disorder Society. 21: 718-22. PMID 16450344 DOI: 10.1002/Mds.20797  0.332
2006 Dabir DV, Robinson MB, Swanson E, Zhang B, Trojanowski JQ, Lee VM, Forman MS. Impaired glutamate transport in a mouse model of tau pathology in astrocytes. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 26: 644-54. PMID 16407562 DOI: 10.1523/Jneurosci.3861-05.2006  0.833
2006 Lee EB, Leng LZ, Zhang B, Kwong L, Trojanowski JQ, Abel T, Lee VM. Targeting amyloid-beta peptide (Abeta) oligomers by passive immunization with a conformation-selective monoclonal antibody improves learning and memory in Abeta precursor protein (APP) transgenic mice. The Journal of Biological Chemistry. 281: 4292-9. PMID 16361260 DOI: 10.1074/Jbc.M511018200  0.632
2006 Duda JE, Giasson BI, Lee VM, Trojanowski JQ. Is the Initial Insult in Parkinson's Disease and Dementia with Lewy Bodies a Neuritic Dystrophy? Annals of the New York Academy of Sciences. 991: 295-297. DOI: 10.1111/J.1749-6632.2003.Tb07488.X  0.652
2005 Jedrziewski MK, Lee VM, Trojanowski JQ. Lowering the risk of Alzheimer's disease: evidence-based practices emerge from new research. Alzheimer's & Dementia : the Journal of the Alzheimer's Association. 1: 152-60. PMID 19595848 DOI: 10.1016/J.Jalz.2005.09.007  0.398
2005 Trojanowski JQ, Lee VM. Commentary on "Diagnosis of Alzheimer's disease: two decades of progress". Alzheimer's disease research: new opportunities for early diagnosis and drug discovery. Alzheimer's & Dementia : the Journal of the Alzheimer's Association. 1: 119-20. PMID 19595841 DOI: 10.1016/J.Jalz.2005.10.004  0.422
2005 Goldman JS, Farmer JM, Wood EM, Johnson JK, Boxer A, Neuhaus J, Lomen-Hoerth C, Wilhelmsen KC, Lee VM, Grossman M, Miller BL. Comparison of family histories in FTLD subtypes and related tauopathies. Neurology. 65: 1817-9. PMID 16344531 DOI: 10.1212/01.Wnl.0000187068.92184.63  0.418
2005 Gilman S, May SJ, Shults CW, Tanner CM, Kukull W, Lee VM, Masliah E, Low P, Sandroni P, Trojanowski JQ, Ozelius L, Foroud T. The North American Multiple System Atrophy Study Group. Journal of Neural Transmission (Vienna, Austria : 1996). 112: 1687-94. PMID 16284910 DOI: 10.1007/S00702-005-0381-6  0.373
2005 Zhang B, Veasey SC, Wood MA, Leng LZ, Kaminski C, Leight S, Abel T, Lee VM, Trojanowski JQ. Impaired rapid eye movement sleep in the Tg2576 APP murine model of Alzheimer's disease with injury to pedunculopontine cholinergic neurons. The American Journal of Pathology. 167: 1361-9. PMID 16251420 DOI: 10.1016/S0002-9440(10)61223-0  0.382
2005 Trojanowski JQ, Lee VM. Rous-Whipple Award Lecture. The Alzheimer's brain: finding out what's broken tells us how to fix it. The American Journal of Pathology. 167: 1183-8. PMID 16251403 DOI: 10.1016/S0002-9440(10)61206-0  0.357
2005 Yoshiyama Y, Uryu K, Higuchi M, Longhi L, Hoover R, Fujimoto S, McIntosh T, Lee VM, Trojanowski JQ. Enhanced neurofibrillary tangle formation, cerebral atrophy, and cognitive deficits induced by repetitive mild brain injury in a transgenic tauopathy mouse model. Journal of Neurotrauma. 22: 1134-41. PMID 16238489 DOI: 10.1089/Neu.2005.22.1134  0.443
2005 McKeith IG, Dickson DW, Lowe J, Emre M, O'Brien JT, Feldman H, Cummings J, Duda JE, Lippa C, Perry EK, Aarsland D, Arai H, Ballard CG, Boeve B, Burn DJ, ... ... Lee VM, et al. Diagnosis and management of dementia with Lewy bodies: third report of the DLB Consortium. Neurology. 65: 1863-72. PMID 16237129 DOI: 10.1212/01.Wnl.0000187889.17253.B1  0.405
2005 Nakashima H, Ishihara T, Suguimoto P, Yokota O, Oshima E, Kugo A, Terada S, Hamamura T, Trojanowski JQ, Lee VM, Kuroda S. Chronic lithium treatment decreases tau lesions by promoting ubiquitination in a mouse model of tauopathies. Acta Neuropathologica. 110: 547-56. PMID 16228182 DOI: 10.1007/S00401-005-1087-4  0.462
2005 Higuchi M, Zhang B, Forman MS, Yoshiyama Y, Trojanowski JQ, Lee VM. Axonal degeneration induced by targeted expression of mutant human tau in oligodendrocytes of transgenic mice that model glial tauopathies. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 25: 9434-43. PMID 16221853 DOI: 10.1523/Jneurosci.2691-05.2005  0.762
2005 Trojanowski JQ, Lee VM. Pathological tau: a loss of normal function or a gain in toxicity? Nature Neuroscience. 8: 1136-7. PMID 16127446 DOI: 10.1038/Nn0905-1136  0.475
2005 Forman MS, Lee VM, Trojanowski JQ. Nosology of Parkinson's disease: looking for the way out of a quagmire. Neuron. 47: 479-82. PMID 16102530 DOI: 10.1016/J.Neuron.2005.07.021  0.736
2005 Yao Y, Clark CM, Trojanowski JQ, Lee VM, Praticò D. Elevation of 12/15 lipoxygenase products in AD and mild cognitive impairment. Annals of Neurology. 58: 623-6. PMID 16037976 DOI: 10.1002/ana.20558  0.402
2005 Trojanowski JQ, Smith AB, Huryn D, Lee VM. Microtubule-stabilising drugs for therapy of Alzheimer's disease and other neurodegenerative disorders with axonal transport impairments. Expert Opinion On Pharmacotherapy. 6: 683-6. PMID 15934894 DOI: 10.1517/14656566.6.5.683  0.49
2005 Mishizen-Eberz AJ, Norris EH, Giasson BI, Hodara R, Ischiropoulos H, Lee VM, Trojanowski JQ, Lynch DR. Cleavage of alpha-synuclein by calpain: potential role in degradation of fibrillized and nitrated species of alpha-synuclein. Biochemistry. 44: 7818-29. PMID 15909996 DOI: 10.1021/Bi047846Q  0.743
2005 Mott RT, Dickson DW, Trojanowski JQ, Zhukareva V, Lee VM, Forman M, Van Deerlin V, Ervin JF, Wang DS, Schmechel DE, Hulette CM. Neuropathologic, biochemical, and molecular characterization of the frontotemporal dementias. Journal of Neuropathology and Experimental Neurology. 64: 420-8. PMID 15892300 DOI: 10.1093/Jnen/64.5.420  0.765
2005 Lee EB, Leng LZ, Lee VM, Trojanowski JQ. Meningoencephalitis associated with passive immunization of a transgenic murine model of Alzheimer's amyloidosis. Febs Letters. 579: 2564-8. PMID 15862291 DOI: 10.1016/J.Febslet.2005.03.070  0.62
2005 Grossman M, Farmer J, Leight S, Work M, Moore P, Van Deerlin V, Pratico D, Clark CM, Coslett HB, Chatterjee A, Gee J, Trojanowski JQ, Lee VM. Cerebrospinal fluid profile in frontotemporal dementia and Alzheimer's disease. Annals of Neurology. 57: 721-9. PMID 15852395 DOI: 10.1002/Ana.20477  0.568
2005 Liu CW, Giasson BI, Lewis KA, Lee VM, Demartino GN, Thomas PJ. A precipitating role for truncated alpha-synuclein and the proteasome in alpha-synuclein aggregation: implications for pathogenesis of Parkinson disease. The Journal of Biological Chemistry. 280: 22670-8. PMID 15840579 DOI: 10.1074/Jbc.M501508200  0.642
2005 Norris EH, Giasson BI, Hodara R, Xu S, Trojanowski JQ, Ischiropoulos H, Lee VM. Reversible inhibition of alpha-synuclein fibrillization by dopaminochrome-mediated conformational alterations. The Journal of Biological Chemistry. 280: 21212-9. PMID 15817478 DOI: 10.1074/Jbc.M412621200  0.736
2005 Forman MS, Lal D, Zhang B, Dabir DV, Swanson E, Lee VM, Trojanowski JQ. Transgenic mouse model of tau pathology in astrocytes leading to nervous system degeneration. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 25: 3539-50. PMID 15814784 DOI: 10.1523/Jneurosci.0081-05.2005  0.835
2005 Yazawa I, Giasson BI, Sasaki R, Zhang B, Joyce S, Uryu K, Trojanowski JQ, Lee VM. Mouse model of multiple system atrophy alpha-synuclein expression in oligodendrocytes causes glial and neuronal degeneration. Neuron. 45: 847-59. PMID 15797547 DOI: 10.1016/J.Neuron.2005.01.032  0.606
2005 Lazarov O, Morfini GA, Lee EB, Farah MH, Szodorai A, DeBoer SR, Koliatsos VE, Kins S, Lee VM, Wong PC, Price DL, Brady ST, Sisodia SS. Axonal transport, amyloid precursor protein, kinesin-1, and the processing apparatus: revisited. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 25: 2386-95. PMID 15745965 DOI: 10.1523/Jneurosci.3089-04.2005  0.564
2005 Easton RM, Cho H, Roovers K, Shineman DW, Mizrahi M, Forman MS, Lee VM, Szabolcs M, de Jong R, Oltersdorf T, Ludwig T, Efstratiadis A, Birnbaum MJ. Role for Akt3/protein kinase Bgamma in attainment of normal brain size. Molecular and Cellular Biology. 25: 1869-78. PMID 15713641 DOI: 10.1128/Mcb.25.5.1869-1878.2005  0.776
2005 Kotzbauer PT, Truax AC, Trojanowski JQ, Lee VM. Altered neuronal mitochondrial coenzyme A synthesis in neurodegeneration with brain iron accumulation caused by abnormal processing, stability, and catalytic activity of mutant pantothenate kinase 2. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 25: 689-98. PMID 15659606 DOI: 10.1523/Jneurosci.4265-04.2005  0.384
2005 Roy S, Zhang B, Lee VM, Trojanowski JQ. Axonal transport defects: a common theme in neurodegenerative diseases. Acta Neuropathologica. 109: 5-13. PMID 15645263 DOI: 10.1007/S00401-004-0952-X  0.679
2005 Lee EB, Zhang B, Liu K, Greenbaum EA, Doms RW, Trojanowski JQ, Lee VM. BACE overexpression alters the subcellular processing of APP and inhibits Abeta deposition in vivo. The Journal of Cell Biology. 168: 291-302. PMID 15642747 DOI: 10.1083/Jcb.200407070  0.714
2005 Zhang B, Maiti A, Shively S, Lakhani F, McDonald-Jones G, Bruce J, Lee EB, Xie SX, Joyce S, Li C, Toleikis PM, Lee VM, Trojanowski JQ. Microtubule-binding drugs offset tau sequestration by stabilizing microtubules and reversing fast axonal transport deficits in a tauopathy model. Proceedings of the National Academy of Sciences of the United States of America. 102: 227-31. PMID 15615853 DOI: 10.1073/Pnas.0406361102  0.617
2005 Lee VM, Kenyon TK, Trojanowski JQ. Transgenic animal models of tauopathies. Biochimica Et Biophysica Acta. 1739: 251-9. PMID 15615643 DOI: 10.1016/J.Bbadis.2004.06.014  0.438
2004 Longhi L, Watson DJ, Saatman KE, Thompson HJ, Zhang C, Fujimoto S, Royo N, Castelbuono D, Raghupathi R, Trojanowski JQ, Lee VM, Wolfe JH, Stocchetti N, McIntosh TK. Ex vivo gene therapy using targeted engraftment of NGF-expressing human NT2N neurons attenuates cognitive deficits following traumatic brain injury in mice. Journal of Neurotrauma. 21: 1723-36. PMID 15684764 DOI: 10.1089/Neu.2004.21.1723  0.34
2004 Popescu A, Lippa CF, Lee VM, Trojanowski JQ. Lewy bodies in the amygdala: increase of alpha-synuclein aggregates in neurodegenerative diseases with tau-based inclusions. Archives of Neurology. 61: 1915-9. PMID 15596612 DOI: 10.1001/Archneur.61.12.1915  0.467
2004 Sung S, Yang H, Uryu K, Lee EB, Zhao L, Shineman D, Trojanowski JQ, Lee VM, Praticò D. Modulation of nuclear factor-kappa B activity by indomethacin influences A beta levels but not A beta precursor protein metabolism in a model of Alzheimer's disease. The American Journal of Pathology. 165: 2197-206. PMID 15579461 DOI: 10.1016/S0002-9440(10)63269-5  0.785
2004 Yao Y, Chinnici C, Tang H, Trojanowski JQ, Lee VM, Praticò D. Brain inflammation and oxidative stress in a transgenic mouse model of Alzheimer-like brain amyloidosis. Journal of Neuroinflammation. 1: 21. PMID 15500684 DOI: 10.1186/1742-2094-1-21  0.397
2004 Cairns NJ, Lee VM, Trojanowski JQ. The cytoskeleton in neurodegenerative diseases. The Journal of Pathology. 204: 438-49. PMID 15495240 DOI: 10.1002/Path.1650  0.571
2004 Ikonomovic MD, Uryu K, Abrahamson EE, Ciallella JR, Trojanowski JQ, Lee VM, Clark RS, Marion DW, Wisniewski SR, DeKosky ST. Alzheimer's pathology in human temporal cortex surgically excised after severe brain injury. Experimental Neurology. 190: 192-203. PMID 15473992 DOI: 10.1016/J.Expneurol.2004.06.011  0.454
2004 Forman MS, Trojanowski JQ, Lee VM. Neurodegenerative diseases: a decade of discoveries paves the way for therapeutic breakthroughs. Nature Medicine. 10: 1055-63. PMID 15459709 DOI: 10.1038/Nm1113  0.773
2004 Ohtake H, Limprasert P, Fan Y, Onodera O, Kakita A, Takahashi H, Bonner LT, Tsuang DW, Murray IV, Lee VM, Trojanowski JQ, Ishikawa A, Idezuka J, Murata M, Toda T, et al. Beta-synuclein gene alterations in dementia with Lewy bodies. Neurology. 63: 805-11. PMID 15365127 DOI: 10.1212/01.Wnl.0000139870.14385.3C  0.691
2004 Hodara R, Norris EH, Giasson BI, Mishizen-Eberz AJ, Lynch DR, Lee VM, Ischiropoulos H. Functional consequences of alpha-synuclein tyrosine nitration: diminished binding to lipid vesicles and increased fibril formation. The Journal of Biological Chemistry. 279: 47746-53. PMID 15364911 DOI: 10.1074/Jbc.M408906200  0.714
2004 Conte V, Uryu K, Fujimoto S, Yao Y, Rokach J, Longhi L, Trojanowski JQ, Lee VM, McIntosh TK, Praticò D. Vitamin E reduces amyloidosis and improves cognitive function in Tg2576 mice following repetitive concussive brain injury. Journal of Neurochemistry. 90: 758-64. PMID 15255955 DOI: 10.1111/J.1471-4159.2004.02560.X  0.326
2004 Nakashima H, Ishihara T, Yokota O, Terada S, Trojanowski JQ, Lee VM, Kuroda S. Effects of alpha-tocopherol on an animal model of tauopathies. Free Radical Biology & Medicine. 37: 176-86. PMID 15203189 DOI: 10.1016/J.Freeradbiomed.2004.04.037  0.453
2004 Cairns NJ, Uryu K, Bigio EH, Mackenzie IR, Gearing M, Duyckaerts C, Yokoo H, Nakazato Y, Jaros E, Perry RH, Arnold SE, Lee VM, Trojanowski JQ. alpha-Internexin aggregates are abundant in neuronal intermediate filament inclusion disease (NIFID) but rare in other neurodegenerative diseases. Acta Neuropathologica. 108: 213-23. PMID 15170578 DOI: 10.1007/S00401-004-0882-7  0.471
2004 Cairns NJ, Zhukareva V, Uryu K, Zhang B, Bigio E, Mackenzie IR, Gearing M, Duyckaerts C, Yokoo H, Nakazato Y, Jaros E, Perry RH, Lee VM, Trojanowski JQ. alpha-internexin is present in the pathological inclusions of neuronal intermediate filament inclusion disease. The American Journal of Pathology. 164: 2153-61. PMID 15161649 DOI: 10.1016/S0002-9440(10)63773-X  0.481
2004 Kotzbauer PT, Giasson BI, Kravitz AV, Golbe LI, Mark MH, Trojanowski JQ, Lee VM. Fibrillization of alpha-synuclein and tau in familial Parkinson's disease caused by the A53T alpha-synuclein mutation. Experimental Neurology. 187: 279-88. PMID 15144854 DOI: 10.1016/J.Expneurol.2004.01.007  0.622
2004 Zhang B, Higuchi M, Yoshiyama Y, Ishihara T, Forman MS, Martinez D, Joyce S, Trojanowski JQ, Lee VM. Retarded axonal transport of R406W mutant tau in transgenic mice with a neurodegenerative tauopathy. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 24: 4657-67. PMID 15140937 DOI: 10.1523/Jneurosci.0797-04.2004  0.773
2004 Wilson CA, Murphy DD, Giasson BI, Zhang B, Trojanowski JQ, Lee VM. Degradative organelles containing mislocalized alpha-and beta-synuclein proliferate in presenilin-1 null neurons. The Journal of Cell Biology. 165: 335-46. PMID 15123735 DOI: 10.1083/Jcb.200403061  0.721
2004 Praticò D, Zhukareva V, Yao Y, Uryu K, Funk CD, Lawson JA, Trojanowski JQ, Lee VM. 12/15-lipoxygenase is increased in Alzheimer's disease: possible involvement in brain oxidative stress. The American Journal of Pathology. 164: 1655-62. PMID 15111312 DOI: 10.1016/S0002-9440(10)63724-8  0.386
2004 Norris EH, Giasson BI, Lee VM. Alpha-synuclein: normal function and role in neurodegenerative diseases. Current Topics in Developmental Biology. 60: 17-54. PMID 15094295 DOI: 10.1016/S0070-2153(04)60002-0  0.758
2004 Macknin JB, Higuchi M, Lee VM, Trojanowski JQ, Doty RL. Olfactory dysfunction occurs in transgenic mice overexpressing human tau protein. Brain Research. 1000: 174-8. PMID 15053964 DOI: 10.1016/J.Brainres.2004.01.047  0.456
2004 Lee VM, Giasson BI, Trojanowski JQ. More than just two peas in a pod: common amyloidogenic properties of tau and alpha-synuclein in neurodegenerative diseases. Trends in Neurosciences. 27: 129-34. PMID 15036877 DOI: 10.1016/J.Tins.2004.01.007  0.7
2004 Crystal AS, Morais VA, Fortna RR, Carlin D, Pierson TC, Wilson CA, Lee VM, Doms RW. Presenilin modulates Pen-2 levels posttranslationally by protecting it from proteasomal degradation. Biochemistry. 43: 3555-63. PMID 15035625 DOI: 10.1021/Bi0361214  0.761
2004 Wilhelmsen KC, Forman MS, Rosen HJ, Alving LI, Goldman J, Feiger J, Lee JV, Segall SK, Kramer JH, Lomen-Hoerth C, Rankin KP, Johnson J, Feiler HS, Weiner MW, Lee VM, et al. 17q-linked frontotemporal dementia-amyotrophic lateral sclerosis without tau mutations with tau and alpha-synuclein inclusions. Archives of Neurology. 61: 398-406. PMID 15023818 DOI: 10.1001/Archneur.61.3.398  0.757
2004 Zhukareva V, Trojanowski JQ, Lee VM. Assessment of pathological tau proteins in frontotemporal dementias: qualitative and quantitative approaches. The American Journal of Geriatric Psychiatry : Official Journal of the American Association For Geriatric Psychiatry. 12: 136-45. PMID 15010343  0.488
2004 Pickering-Brown S, Baker M, Bird T, Trojanowski J, Lee V, Morris H, Rossor M, Janssen JC, Neary D, Craufurd D, Richardson A, Snowden J, Hardy J, Mann D, Hutton M. Evidence of a founder effect in families with frontotemporal dementia that harbor the tau +16 splice mutation. American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics. 125: 79-82. PMID 14755449 DOI: 10.1002/Ajmg.B.20083  0.445
2004 Rizzu P, Hinkle DA, Zhukareva V, Bonifati V, Severijnen LA, Martinez D, Ravid R, Kamphorst W, Eberwine JH, Lee VM, Trojanowski JQ, Heutink P. DJ-1 colocalizes with tau inclusions: a link between parkinsonism and dementia. Annals of Neurology. 55: 113-8. PMID 14705119 DOI: 10.1002/Ana.10782  0.491
2004 Dabir DV, Trojanowski JQ, Richter-Landsberg C, Lee VM, Forman MS. Expression of the small heat-shock protein alphaB-crystallin in tauopathies with glial pathology. The American Journal of Pathology. 164: 155-66. PMID 14695329  0.838
2004 Fortna RR, Crystal AS, Morais VA, Pijak DS, Lee VM, Doms RW. Membrane topology and nicastrin-enhanced endoproteolysis of APH-1, a component of the gamma-secretase complex. The Journal of Biological Chemistry. 279: 3685-93. PMID 14593096 DOI: 10.1074/Jbc.M310505200  0.675
2004 Nakashima H, Ishihara T, Terada S, Yokota O, Kugo A, Hamamura T, Trojanowski JQ, Lee VM, Kuroda S. P4-426 Effect of chronic lithium treatment on an animal model of tauopathies Neurobiology of Aging. 25. DOI: 10.1016/S0197-4580(04)81982-1  0.345
2004 Yang H, Yao Y, Uryu K, Lee EB, Zhao L, Funk C, Trojanowski JQ, Lee VM, Pratico D. P2-112 Selective suppression of NF-κB by indomethacin modulates Aβlevels and deposition but not metabolism in a model of Alzheimer disease Neurobiology of Aging. 25: S256. DOI: 10.1016/S0197-4580(04)80859-5  0.635
2004 Yoshiyama Y, Zhang B, Higuchi M, Trojanowski JQ, Lee VM. P2-058 Synapse loss is an early pathological manifestation in a tauopthy model, P301S mutant tau transgenic mice Neurobiology of Aging. 25: S240. DOI: 10.1016/S0197-4580(04)80805-4  0.436
2004 Practico D, Zhukareva V, Yao Y, Uryu K, Funk CD, Lee VM, Trojanowski JQ. P1-389 Increase of 12/15 lipooxygenase AD: potential role in oxidative stress Neurobiology of Aging. 25: S209. DOI: 10.1016/S0197-4580(04)80701-2  0.393
2004 Norris EH, Giasson BI, Xu S, Hodara R, Trojanowski JQ, Ischiropoulos H, Lee V. P1-302 Implications of dopamine-induced modificationsof alpha-synuclein protein in the pathogenesis of Parkinson's disease Neurobiology of Aging. 25: S182. DOI: 10.1016/S0197-4580(04)80615-8  0.764
2004 Cairns NJ, Zhukareva V, Uryu K, Bigio E, Makenzie IR, Geaing M, Duyckaerts C, Yokoo H, Nakazato Y, Jaros E, Perry RH, Lee VM, Trojanowski JQ. O4-06-01 α-Internexin is present in the hallmark lesions of neuronal intermediate filament inclusion disease Neurobiology of Aging. 25: S85. DOI: 10.1016/S0197-4580(04)80288-4  0.434
2004 Forman MS, Lal D, Zhang B, Dabir D, Lee VM, Trojanowski JQ. O1-04-01 Transgenic mouse models of TAU pathology in astrocytes leading to nervous system degeneration Neurobiology of Aging. 25: S16. DOI: 10.1016/S0197-4580(04)80052-6  0.799
2004 Lee VM. S1-01-06 Intracellular and secreted neuronal amyloid beta peptides in AD Neurobiology of Aging. 25: S3. DOI: 10.1016/S0197-4580(04)80009-5  0.338
2003 Clark CM, Xie S, Chittams J, Ewbank D, Peskind E, Galasko D, Morris JC, McKeel DW, Farlow M, Weitlauf SL, Quinn J, Kaye J, Knopman D, Arai H, Doody RS, ... ... Lee VM, et al. Cerebrospinal fluid tau and beta-amyloid: how well do these biomarkers reflect autopsy-confirmed dementia diagnoses? Archives of Neurology. 60: 1696-702. PMID 14676043 DOI: 10.1001/Archneur.60.12.1696  0.448
2003 Kung HF, Kung MP, Zhuang ZP, Hou C, Lee CW, Plössl K, Zhuang B, Skovronsky DM, Lee VM, Trojanowski JQ. Iodinated tracers for imaging amyloid plaques in the brain. Molecular Imaging and Biology : Mib : the Official Publication of the Academy of Molecular Imaging. 5: 418-26. PMID 14667496 DOI: 10.1016/J.Mibio.2003.09.003  0.778
2003 Sung S, Yao Y, Uryu K, Yang H, Lee VM, Trojanowski JQ, Praticò D. Early vitamin E supplementation in young but not aged mice reduces Abeta levels and amyloid deposition in a transgenic model of Alzheimer's disease. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 18: 323-5. PMID 14656990 DOI: 10.1096/Fj.03-0961Fje  0.381
2003 Söderberg L, Zhukareva V, Bogdanovic N, Hashimoto T, Winblad B, Iwatsubo T, Lee VM, Trojanowski JQ, Näslund J. Molecular identification of AMY, an Alzheimer disease amyloid-associated protein. Journal of Neuropathology and Experimental Neurology. 62: 1108-17. PMID 14656069 DOI: 10.1093/Jnen/62.11.1108  0.434
2003 Uryu K, Giasson BI, Longhi L, Martinez D, Murray I, Conte V, Nakamura M, Saatman K, Talbot K, Horiguchi T, McIntosh T, Lee VM, Trojanowski JQ. Age-dependent synuclein pathology following traumatic brain injury in mice. Experimental Neurology. 184: 214-24. PMID 14637093 DOI: 10.1016/S0014-4886(03)00245-0  0.763
2003 Yoshiyama Y, Zhang B, Bruce J, Trojanowski JQ, Lee VM. Reduction of detyrosinated microtubules and Golgi fragmentation are linked to tau-induced degeneration in astrocytes. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 23: 10662-71. PMID 14627651  0.456
2003 Wilson CA, Doms RW, Lee VM. Distinct presenilin-dependent and presenilin-independent gamma-secretases are responsible for total cellular Abeta production. Journal of Neuroscience Research. 74: 361-9. PMID 14598312 DOI: 10.1002/Jnr.10776  0.516
2003 Nicholl DJ, Greenstone MA, Clarke CE, Rizzu P, Crooks D, Crowe A, Trojanowski JQ, Lee VM, Heutink P. An English kindred with a novel recessive tauopathy and respiratory failure. Annals of Neurology. 54: 682-6. PMID 14595660 DOI: 10.1002/Ana.10747  0.377
2003 Lee VM, Trojanowski JQ. Research on the brain. Science of Aging Knowledge Environment : Sage Ke. 2003: pe29. PMID 14573852 DOI: 10.1126/Sageke.2003.42.Pe29  0.372
2003 Giasson BI, Lee VM, Trojanowski JQ. Interactions of amyloidogenic proteins. Neuromolecular Medicine. 4: 49-58. PMID 14528052 DOI: 10.1385/Nmm:4:1-2:49  0.678
2003 Goldbaum O, Oppermann M, Handschuh M, Dabir D, Zhang B, Forman MS, Trojanowski JQ, Lee VM, Richter-Landsberg C. Proteasome inhibition stabilizes tau inclusions in oligodendroglial cells that occur after treatment with okadaic acid. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 23: 8872-80. PMID 14523089 DOI: 10.1523/Jneurosci.23-26-08872.2003  0.823
2003 Van Deerlin VM, Gill LH, Farmer JM, Trojanowski JQ, Lee VM. Familial frontotemporal dementia: from gene discovery to clinical molecular diagnostics. Clinical Chemistry. 49: 1717-25. PMID 14500612 DOI: 10.1373/49.10.1717  0.408
2003 Pawlyk AC, Giasson BI, Sampathu DM, Perez FA, Lim KL, Dawson VL, Dawson TM, Palmiter RD, Trojanowski JQ, Lee VM. Novel monoclonal antibodies demonstrate biochemical variation of brain parkin with age. The Journal of Biological Chemistry. 278: 48120-8. PMID 12972409 DOI: 10.1074/Jbc.M306889200  0.798
2003 Crystal AS, Giasson BI, Crowe A, Kung MP, Zhuang ZP, Trojanowski JQ, Lee VM. A comparison of amyloid fibrillogenesis using the novel fluorescent compound K114. Journal of Neurochemistry. 86: 1359-68. PMID 12950445 DOI: 10.1046/J.1471-4159.2003.01949.X  0.812
2003 Horiguchi T, Uryu K, Giasson BI, Ischiropoulos H, LightFoot R, Bellmann C, Richter-Landsberg C, Lee VM, Trojanowski JQ. Nitration of tau protein is linked to neurodegeneration in tauopathies. The American Journal of Pathology. 163: 1021-31. PMID 12937143 DOI: 10.1016/S0002-9440(10)63462-1  0.648
2003 Trojanowski JQ, Lee VM. Meeting summary--cell biology of Parkinson's disease and related neurodegenerative disorders. Science of Aging Knowledge Environment : Sage Ke. 2003: PE23. PMID 12917484 DOI: 10.1126/Sageke.2003.32.Pe23  0.35
2003 Morais VA, Crystal AS, Pijak DS, Carlin D, Costa J, Lee VM, Doms RW. The transmembrane domain region of nicastrin mediates direct interactions with APH-1 and the gamma-secretase complex. The Journal of Biological Chemistry. 278: 43284-91. PMID 12917438 DOI: 10.1074/Jbc.M305685200  0.69
2003 Forman MS, Lee VM, Trojanowski JQ. 'Unfolding' pathways in neurodegenerative disease. Trends in Neurosciences. 26: 407-10. PMID 12900170 DOI: 10.1016/S0166-2236(03)00197-8  0.746
2003 Mishizen-Eberz AJ, Guttmann RP, Giasson BI, Day GA, Hodara R, Ischiropoulos H, Lee VM, Trojanowski JQ, Lynch DR. Distinct cleavage patterns of normal and pathologic forms of alpha-synuclein by calpain I in vitro. Journal of Neurochemistry. 86: 836-47. PMID 12887682 DOI: 10.1046/J.1471-4159.2003.01878.X  0.595
2003 Giasson BI, Lee VM. Are ubiquitination pathways central to Parkinson's disease? Cell. 114: 1-8. PMID 12859888 DOI: 10.1016/S0092-8674(03)00509-9  0.538
2003 Murray IV, Giasson BI, Quinn SM, Koppaka V, Axelsen PH, Ischiropoulos H, Trojanowski JQ, Lee VM. Role of alpha-synuclein carboxy-terminus on fibril formation in vitro. Biochemistry. 42: 8530-40. PMID 12859200 DOI: 10.1021/Bi027363R  0.742
2003 Norris EH, Giasson BI, Ischiropoulos H, Lee VM. Effects of oxidative and nitrative challenges on alpha-synuclein fibrillogenesis involve distinct mechanisms of protein modifications. The Journal of Biological Chemistry. 278: 27230-40. PMID 12857790 DOI: 10.1074/Jbc.M212436200  0.721
2003 Trojanowski JQ, Lee VM. Parkinson's disease and related alpha-synucleinopathies are brain amyloidoses. Annals of the New York Academy of Sciences. 991: 107-10. PMID 12846979 DOI: 10.1111/J.1749-6632.2003.Tb07468.X  0.505
2003 Sampathu DM, Giasson BI, Pawlyk AC, Trojanowski JQ, Lee VM. Ubiquitination of alpha-synuclein is not required for formation of pathological inclusions in alpha-synucleinopathies. The American Journal of Pathology. 163: 91-100. PMID 12819014 DOI: 10.1016/S0002-9440(10)63633-4  0.803
2003 Giasson BI, Mabon ME, Duda JE, Montine TJ, Robertson D, Hurtig HI, Lee VM, Trojanowski JQ. Tau and 14-3-3 in glial cytoplasmic inclusions of multiple system atrophy. Acta Neuropathologica. 106: 243-50. PMID 12811584 DOI: 10.1007/S00401-003-0726-X  0.634
2003 Fung KM, Rorke LB, Giasson B, Lee VM, Trojanowski JQ. Expression of alpha-, beta-, and gamma-synuclein in glial tumors and medulloblastomas. Acta Neuropathologica. 106: 167-75. PMID 12783249 DOI: 10.1007/S00401-003-0718-X  0.634
2003 Dentchev T, Milam AH, Lee VM, Trojanowski JQ, Dunaief JL. Amyloid-beta is found in drusen from some age-related macular degeneration retinas, but not in drusen from normal retinas. Molecular Vision. 9: 184-90. PMID 12764254  0.368
2003 Phiel CJ, Wilson CA, Lee VM, Klein PS. GSK-3alpha regulates production of Alzheimer's disease amyloid-beta peptides. Nature. 423: 435-9. PMID 12761548 DOI: 10.1038/Nature01640  0.566
2003 Watson DJ, Longhi L, Lee EB, Fulp CT, Fujimoto S, Royo NC, Passini MA, Trojanowski JQ, Lee VM, McIntosh TK, Wolfe JH. Genetically modified NT2N human neuronal cells mediate long-term gene expression as CNS grafts in vivo and improve functional cognitive outcome following experimental traumatic brain injury. Journal of Neuropathology and Experimental Neurology. 62: 368-80. PMID 12722829 DOI: 10.1093/Jnen/62.4.368  0.599
2003 Giasson BI, Forman MS, Higuchi M, Golbe LI, Graves CL, Kotzbauer PT, Trojanowski JQ, Lee VM. Initiation and synergistic fibrillization of tau and alpha-synuclein. Science (New York, N.Y.). 300: 636-40. PMID 12714745 DOI: 10.1126/Science.1082324  0.806
2003 Zhukareva V, Sundarraj S, Mann D, Sjogren M, Blenow K, Clark CM, McKeel DW, Goate A, Lippa CF, Vonsattel JP, Growdon JH, Trojanowski JQ, Lee VM. Selective reduction of soluble tau proteins in sporadic and familial frontotemporal dementias: an international follow-up study. Acta Neuropathologica. 105: 469-76. PMID 12677447 DOI: 10.1007/S00401-002-0668-8  0.451
2003 Kung MP, Skovronsky DM, Hou C, Zhuang ZP, Gur TL, Zhang B, Trojanowski JQ, Lee VM, Kung HF. Detection of amyloid plaques by radioligands for Abeta40 and Abeta42: potential imaging agents in Alzheimer's patients. Journal of Molecular Neuroscience : Mn. 20: 15-24. PMID 12663930 DOI: 10.1385/Jmn:20:1:15  0.772
2003 Crystal AS, Morais VA, Pierson TC, Pijak DS, Carlin D, Lee VM, Doms RW. Membrane topology of gamma-secretase component PEN-2. The Journal of Biological Chemistry. 278: 20117-23. PMID 12639958 DOI: 10.1074/Jbc.M213107200  0.685
2003 Murray IJ, Medford MA, Guan HP, Rueter SM, Trojanowski JQ, Lee VM. Synphilin in normal human brains and in synucleinopathies: studies with new antibodies. Acta Neuropathologica. 105: 177-84. PMID 12536229 DOI: 10.1007/S00401-002-0629-2  0.418
2003 Lee EB, Skovronsky DM, Abtahian F, Doms RW, Lee VM. Secretion and intracellular generation of truncated Abeta in beta-site amyloid-beta precursor protein-cleaving enzyme expressing human neurons. The Journal of Biological Chemistry. 278: 4458-66. PMID 12480937 DOI: 10.1074/Jbc.M210105200  0.805
2002 Giasson BI, Sampathu DM, Wilson CA, Vogelsberg-Ragaglia V, Mushynski WE, Lee VM. The environmental toxin arsenite induces tau hyperphosphorylation. Biochemistry. 41: 15376-87. PMID 12484777 DOI: 10.1021/Bi026813C  0.808
2002 Heuer GG, Passini MA, Jiang K, Parente MK, Lee VM, Trojanowski JQ, Wolfe JH. Selective neurodegeneration in murine mucopolysaccharidosis VII is progressive and reversible. Annals of Neurology. 52: 762-70. PMID 12447930 DOI: 10.1002/Ana.10373  0.369
2002 Higuchi M, Lee VM, Trojanowski JQ. Tau and axonopathy in neurodegenerative disorders. Neuromolecular Medicine. 2: 131-50. PMID 12428808 DOI: 10.1385/Nmm:2:2:131  0.429
2002 Trojanowski JQ, Lee VM. Parkinson's disease and related synucleinopathies are a new class of nervous system amyloidoses. Neurotoxicology. 23: 457-60. PMID 12428717 DOI: 10.1016/S0161-813X(02)00065-7  0.338
2002 Hasegawa M, Fujiwara H, Nonaka T, Wakabayashi K, Takahashi H, Lee VM, Trojanowski JQ, Mann D, Iwatsubo T. Phosphorylated alpha-synuclein is ubiquitinated in alpha-synucleinopathy lesions. The Journal of Biological Chemistry. 277: 49071-6. PMID 12377775 DOI: 10.1074/Jbc.M208046200  0.396
2002 Zhukareva V, Shah K, Uryu K, Braak H, Del Tredici K, Sundarraj S, Clark C, Trojanowski JQ, Lee VM. Biochemical analysis of tau proteins in argyrophilic grain disease, Alzheimer's disease, and Pick's disease : a comparative study. The American Journal of Pathology. 161: 1135-41. PMID 12368187 DOI: 10.1016/S0002-9440(10)64390-8  0.451
2002 Poorkaj P, Muma NA, Zhukareva V, Cochran EJ, Shannon KM, Hurtig H, Koller WC, Bird TD, Trojanowski JQ, Lee VM, Schellenberg GD. An R5L tau mutation in a subject with a progressive supranuclear palsy phenotype. Annals of Neurology. 52: 511-6. PMID 12325083 DOI: 10.1002/Ana.10340  0.405
2002 Kung MP, Hou C, Zhuang ZP, Skovronsky DM, Zhang B, Gur TL, Trojanowski JQ, Lee VM, Kung HF. Radioiodinated styrylbenzene derivatives as potential SPECT imaging agents for amyloid plaque detection in Alzheimer's disease. Journal of Molecular Neuroscience : Mn. 19: 7-10. PMID 12212796 DOI: 10.1007/S12031-002-0003-9  0.764
2002 Duda JE, Giasson BI, Mabon ME, Lee VM, Trojanowski JQ. Novel antibodies to synuclein show abundant striatal pathology in Lewy body diseases. Annals of Neurology. 52: 205-10. PMID 12210791 DOI: 10.1002/Ana.10279  0.619
2002 Trojanowski JQ, Lee VM. The role of tau in Alzheimer's disease. The Medical Clinics of North America. 86: 615-27. PMID 12168561 DOI: 10.1016/S0025-7125(02)00002-0  0.518
2002 Higuchi M, Ishihara T, Zhang B, Hong M, Andreadis A, Trojanowski J, Lee VM. Transgenic mouse model of tauopathies with glial pathology and nervous system degeneration. Neuron. 35: 433-46. PMID 12165467 DOI: 10.1016/S0896-6273(02)00789-4  0.471
2002 Wilson CA, Doms RW, Zheng H, Lee VM. Presenilins are not required for A beta 42 production in the early secretory pathway. Nature Neuroscience. 5: 849-55. PMID 12145638 DOI: 10.1038/Nn898  0.491
2002 Pan ZZ, Bruening W, Giasson BI, Lee VM, Godwin AK. Gamma-synuclein promotes cancer cell survival and inhibits stress- and chemotherapy drug-induced apoptosis by modulating MAPK pathways. The Journal of Biological Chemistry. 277: 35050-60. PMID 12121974 DOI: 10.1074/Jbc.M201650200  0.48
2002 Zhukareva V, Mann D, Pickering-Brown S, Uryu K, Shuck T, Shah K, Grossman M, Miller BL, Hulette CM, Feinstein SC, Trojanowski JQ, Lee VM. Sporadic Pick's disease: a tauopathy characterized by a spectrum of pathological tau isoforms in gray and white matter. Annals of Neurology. 51: 730-9. PMID 12112079 DOI: 10.1002/Ana.10222  0.588
2002 Trojanowski JQ, Ishihara T, Higuchi M, Yoshiyama Y, Hong M, Zhang B, Forman MS, Zhukareva V, Lee VM. Amyotrophic lateral sclerosis/parkinsonism dementia complex: transgenic mice provide insights into mechanisms underlying a common tauopathy in an ethnic minority on Guam. Experimental Neurology. 176: 1-11. PMID 12093078 DOI: 10.1006/Exnr.2002.7940  0.766
2002 Duda JE, Giasson BI, Mabon ME, Miller DC, Golbe LI, Lee VM, Trojanowski JQ. Concurrence of alpha-synuclein and tau brain pathology in the Contursi kindred. Acta Neuropathologica. 104: 7-11. PMID 12070658 DOI: 10.1007/S00401-002-0563-3  0.641
2002 Giasson BI, Duda JE, Quinn SM, Zhang B, Trojanowski JQ, Lee VM. Neuronal alpha-synucleinopathy with severe movement disorder in mice expressing A53T human alpha-synuclein. Neuron. 34: 521-33. PMID 12062037 DOI: 10.1016/S0896-6273(02)00682-7  0.604
2002 Forman MS, Zhukareva V, Bergeron C, Chin SS, Grossman M, Clark C, Lee VM, Trojanowski JQ. Signature tau neuropathology in gray and white matter of corticobasal degeneration. The American Journal of Pathology. 160: 2045-53. PMID 12057909 DOI: 10.1016/S0002-9440(10)61154-6  0.793
2002 Giasson BI, Ischiropoulos H, Lee VM, Trojanowski JQ. The relationship between oxidative/nitrative stress and pathological inclusions in Alzheimer's and Parkinson's diseases. Free Radical Biology & Medicine. 32: 1264-75. PMID 12057764 DOI: 10.1016/S0891-5849(02)00804-3  0.622
2002 Praticò D, Uryu K, Sung S, Tang S, Trojanowski JQ, Lee VM. Aluminum modulates brain amyloidosis through oxidative stress in APP transgenic mice. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 16: 1138-40. PMID 12039845 DOI: 10.1096/Fj.02-0012Fje  0.398
2002 Forman MS, Schmidt ML, Kasturi S, Perl DP, Lee VM, Trojanowski JQ. Tau and alpha-synuclein pathology in amygdala of Parkinsonism-dementia complex patients of Guam. The American Journal of Pathology. 160: 1725-31. PMID 12000724 DOI: 10.1016/S0002-9440(10)61119-4  0.79
2002 Nelson PT, Kondziolka D, Wechsler L, Goldstein S, Gebel J, DeCesare S, Elder EM, Zhang PJ, Jacobs A, McGrogan M, Lee VM, Trojanowski JQ. Clonal human (hNT) neuron grafts for stroke therapy: neuropathology in a patient 27 months after implantation. The American Journal of Pathology. 160: 1201-6. PMID 11943704 DOI: 10.1016/S0002-9440(10)62546-1  0.323
2002 Judkins AR, Forman MS, Uryu K, Hinkle DA, Asbury AK, Lee VM, Trojanowski JQ. Co-occurrence of Parkinson's disease with progressive supranuclear palsy. Acta Neuropathologica. 103: 526-30. PMID 11935271 DOI: 10.1007/S00401-001-0483-7  0.793
2002 Liu K, Doms RW, Lee VM. Glu11 site cleavage and N-terminally truncated A beta production upon BACE overexpression. Biochemistry. 41: 3128-36. PMID 11863452 DOI: 10.1021/Bi015800G  0.441
2002 Huse JT, Liu K, Pijak DS, Carlin D, Lee VM, Doms RW. Beta-secretase processing in the trans-Golgi network preferentially generates truncated amyloid species that accumulate in Alzheimer's disease brain. The Journal of Biological Chemistry. 277: 16278-84. PMID 11847218 DOI: 10.1074/Jbc.M111141200  0.452
2002 Mitchell TW, Mufson EJ, Schneider JA, Cochran EJ, Nissanov J, Han LY, Bienias JL, Lee VM, Trojanowski JQ, Bennett DA, Arnold SE. Parahippocampal tau pathology in healthy aging, mild cognitive impairment, and early Alzheimer's disease. Annals of Neurology. 51: 182-9. PMID 11835374 DOI: 10.1002/Ana.10086  0.394
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