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David C. Klein - Publications

Affiliations: 
National Institute of Child Health and Human Development, Bethesda, MD, United States 
Area:
Melatonin Biosynthesis
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Year Citation  Score
2019 Carstensen MB, Hertz H, Bering T, Møller M, Rohde K, Klein DC, Coon SL, Rath MF. Circadian regulation and molecular role of the Bsx homeobox gene in the adult pineal gland. Journal of Pineal Research. e12629. PMID 31808568 DOI: 10.1111/jpi.12629  0.399
2019 Hertz H, Carstensen MB, Bering T, Rohde K, Møller M, Granau AM, Coon SL, Klein DC, Rath MF. The Lhx4 homeobox transcript in the rat pineal gland: adrenergic regulation and impact on transcripts encoding melatonin-synthesizing enzymes. Journal of Pineal Research. e12616. PMID 31609018 DOI: 10.1111/jpi.12616  0.405
2018 Mays JC, Kelly MC, Coon SL, Holtzclaw L, Rath MF, Kelley MW, Klein DC. Single-cell RNA sequencing of the mammalian pineal gland identifies two pinealocyte subtypes and cell type-specific daily patterns of gene expression. Plos One. 13: e0205883. PMID 30347410 DOI: 10.1371/Journal.Pone.0205883  0.357
2017 Backlund PS, Urbanski HF, Doll MA, Hein DW, Bozinoski M, Mason CE, Coon SL, Klein DC. Daily Rhythm in Plasma N-acetyltryptamine. Journal of Biological Rhythms. 748730417700458. PMID 28466676 DOI: 10.1177/0748730417700458  0.338
2016 Ben-Moshe Livne Z, Alon S, Vallone D, Bayleyen Y, Tovin A, Shainer I, Nisembaum LG, Aviram I, Smadja-Storz S, Fuentes M, Falcón J, Eisenberg E, Klein DC, Burgess HA, Foulkes NS, et al. Genetically Blocking the Zebrafish Pineal Clock Affects Circadian Behavior. Plos Genetics. 12: e1006445. PMID 27870848 DOI: 10.1371/Journal.Pgen.1006445  0.374
2016 Hartley SW, Mullikin JC, Klein DC, Park M, Coon SL. Alternative Isoform Analysis of Ttc8 Expression in the Rat Pineal Gland Using a Multi-Platform Sequencing Approach Reveals Neural Regulation. Plos One. 11: e0163590. PMID 27684375 DOI: 10.1371/Journal.Pone.0163590  0.311
2016 Rath MF, Coon SL, Amaral FG, Weller JL, Møller M, Klein DC. Melatonin synthesis: Acetylserotonin O-methyltransferase (ASMT) is strongly expressed in a subpopulation of pinealocytes in the male rat pineal gland. Endocrinology. en20151888. PMID 26950199 DOI: 10.1210/en.2015-1888  0.383
2015 Hartley SW, Coon SL, Savastano LE, Mullikin JC, Fu C, Klein DC. Neurotranscriptomics: The Effects of Neonatal Stimulus Deprivation on the Rat Pineal Transcriptome. Plos One. 10: e0137548. PMID 26367423 DOI: 10.1371/Journal.Pone.0137548  0.362
2015 Yamazaki F, Møller M, Fu C, Clokie SJ, Zykovich A, Coon SL, Klein DC, Rath MF. The Lhx9 homeobox gene controls pineal gland development and prevents postnatal hydrocephalus. Brain Structure & Function. 220: 1497-509. PMID 24647753 DOI: 10.1007/s00429-014-0740-x  0.311
2014 Falcón J, Coon SL, Besseau L, Cazaméa-Catalan D, Fuentès M, Magnanou E, Paulin CH, Boeuf G, Sauzet S, Jørgensen EH, Mazan S, Wolf YI, Koonin EV, Steinbach PJ, Hyodo S, ... Klein DC, et al. Drastic neofunctionalization associated with evolution of the timezyme AANAT 500 Mya. Proceedings of the National Academy of Sciences of the United States of America. 111: 314-9. PMID 24351931 DOI: 10.1073/Pnas.1312634110  0.38
2013 Kucka M, Bjelobaba I, Clokie SJ, Klein DC, Stojilkovic SS. Female-specific induction of rat pituitary dentin matrix protein-1 by GnRH. Molecular Endocrinology (Baltimore, Md.). 27: 1840-55. PMID 24085820 DOI: 10.1210/me.2013-1068  0.354
2013 Matsuo M, Coon SL, Klein DC. RGS2 is a feedback inhibitor of melatonin production in the pineal gland. Febs Letters. 587: 1392-8. PMID 23523917 DOI: 10.1016/j.febslet.2013.03.016  0.353
2013 Rath MF, Rohde K, Klein DC, Møller M. Homeobox genes in the rodent pineal gland: roles in development and phenotype maintenance. Neurochemical Research. 38: 1100-12. PMID 23076630 DOI: 10.1007/s11064-012-0906-y  0.331
2012 Tovin A, Alon S, Ben-Moshe Z, Mracek P, Vatine G, Foulkes NS, Jacob-Hirsch J, Rechavi G, Toyama R, Coon SL, Klein DC, Eisenberg E, Gothilf Y. Systematic identification of rhythmic genes reveals camk1gb as a new element in the circadian clockwork. Plos Genetics. 8: e1003116. PMID 23284293 DOI: 10.1371/Journal.Pgen.1003116  0.356
2012 Coon SL, Munson PJ, Cherukuri PF, Sugden D, Rath MF, Møller M, Clokie SJ, Fu C, Olanich ME, Rangel Z, Werner T, Mullikin JC, Klein DC. Circadian changes in long noncoding RNAs in the pineal gland. Proceedings of the National Academy of Sciences of the United States of America. 109: 13319-24. PMID 22864914 DOI: 10.1073/Pnas.1207748109  0.378
2012 Ochocinska MJ, Muñoz EM, Veleri S, Weller JL, Coon SL, Pozdeyev N, Iuvone PM, Goebbels S, Furukawa T, Klein DC. NeuroD1 is required for survival of photoreceptors but not pinealocytes: results from targeted gene deletion studies. Journal of Neurochemistry. 123: 44-59. PMID 22784109 DOI: 10.1111/J.1471-4159.2012.07870.X  0.329
2011 Rovsing L, Clokie S, Bustos DM, Rohde K, Coon SL, Litman T, Rath MF, Møller M, Klein DC. Crx broadly modulates the pineal transcriptome. Journal of Neurochemistry. 119: 262-74. PMID 21797868 DOI: 10.1111/j.1471-4159.2011.07405.x  0.349
2011 Haque R, Chong NW, Ali F, Chaurasia SS, Sengupta T, Chun E, Howell JC, Klein DC, Iuvone PM. Melatonin synthesis in retina: cAMP-dependent transcriptional regulation of chicken arylalkylamine N-acetyltransferase by a CRE-like sequence and a TTATT repeat motif in the proximal promoter. Journal of Neurochemistry. 119: 6-17. PMID 21790603 DOI: 10.1111/J.1471-4159.2011.07397.X  0.34
2011 Rohde K, Klein DC, Møller M, Rath MF. Rax : developmental and daily expression patterns in the rat pineal gland and retina. Journal of Neurochemistry. 118: 999-1007. PMID 21749377 DOI: 10.1111/j.1471-4159.2011.07385.x  0.387
2011 Zilberman-Peled B, Bransburg-Zabary S, Klein DC, Gothilf Y. Molecular evolution of multiple arylalkylamine N-acetyltransferase (AANAT) in fish. Marine Drugs. 9: 906-21. PMID 21673898 DOI: 10.3390/md9050906  0.306
2011 Bustos DM, Bailey MJ, Sugden D, Carter DA, Rath MF, Møller M, Coon SL, Weller JL, Klein DC. Global daily dynamics of the pineal transcriptome. Cell and Tissue Research. 344: 1-11. PMID 21302120 DOI: 10.1007/S00441-010-1094-1  0.374
2010 Pavlicek J, Sauzet S, Besseau L, Coon SL, Weller JL, Boeuf G, Gaildrat P, Omelchenko MV, Koonin EV, Falcón J, Klein DC. Evolution of AANAT: expansion of the gene family in the cephalochordate amphioxus. Bmc Evolutionary Biology. 10: 154. PMID 20500864 DOI: 10.1186/1471-2148-10-154  0.362
2010 Haque R, Ali FG, Biscoglia R, Abey J, Weller J, Klein D, Iuvone PM. CLOCK and NPAS2 have overlapping roles in the circadian oscillation of arylalkylamine N-acetyltransferase mRNA in chicken cone photoreceptors. Journal of Neurochemistry. 113: 1296-306. PMID 20345751 DOI: 10.1111/J.1471-4159.2010.06698.X  0.376
2010 Kim JS, Bailey MJ, Weller JL, Sugden D, Rath MF, Møller M, Klein DC. Thyroid hormone and adrenergic signaling interact to control pineal expression of the dopamine receptor D4 gene (Drd4). Molecular and Cellular Endocrinology. 314: 128-35. PMID 19482058 DOI: 10.1016/j.mce.2009.05.013  0.344
2009 Toyama R, Chen X, Jhawar N, Aamar E, Epstein J, Reany N, Alon S, Gothilf Y, Klein DC, Dawid IB. Transcriptome analysis of the zebrafish pineal gland. Developmental Dynamics : An Official Publication of the American Association of Anatomists. 238: 1813-26. PMID 19504458 DOI: 10.1002/dvdy.21988  0.309
2009 Kim JS, Coon SL, Weller JL, Blackshaw S, Rath MF, Møller M, Klein DC. Muscleblind-like 2: circadian expression in the mammalian pineal gland is controlled by an adrenergic-cAMP mechanism. Journal of Neurochemistry. 110: 756-64. PMID 19457059 DOI: 10.1111/j.1471-4159.2009.06184.x  0.401
2009 Kim SM, Power A, Brown TM, Constance CM, Coon SL, Nishimura T, Hirai H, Cai T, Eisner C, Weaver DR, Piggins HD, Klein DC, Schnermann J, Notkins AL. Deletion of the secretory vesicle proteins IA-2 and IA-2beta disrupts circadian rhythms of cardiovascular and physical activity. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 23: 3226-32. PMID 19433624 DOI: 10.1096/Fj.09-132019  0.302
2009 Bailey MJ, Coon SL, Carter DA, Humphries A, Kim JS, Shi Q, Gaildrat P, Morin F, Ganguly S, Hogenesch JB, Weller JL, Rath MF, Møller M, Baler R, Sugden D, ... ... Klein DC, et al. Night/day changes in pineal expression of >600 genes: central role of adrenergic/cAMP signaling. The Journal of Biological Chemistry. 284: 7606-22. PMID 19103603 DOI: 10.1074/Jbc.M808394200  0.351
2009 Rath MF, Bailey MJ, Kim JS, Coon SL, Klein DC, Møller M. Developmental and daily expression of the Pax4 and Pax6 homeobox genes in the rat retina: localization of Pax4 in photoreceptor cells. Journal of Neurochemistry. 108: 285-94. PMID 19012751 DOI: 10.1111/j.1471-4159.2008.05765.x  0.331
2009 Rath MF, Bailey MJ, Kim JS, Ho AK, Gaildrat P, Coon SL, Møller M, Klein DC. Developmental and diurnal dynamics of Pax4 expression in the mammalian pineal gland: nocturnal down-regulation is mediated by adrenergic-cyclic adenosine 3',5'-monophosphate signaling. Endocrinology. 150: 803-11. PMID 18818287 DOI: 10.1210/en.2008-0882  0.406
2008 Klitten LL, Rath MF, Coon SL, Kim JS, Klein DC, Møller M. Localization and regulation of dopamine receptor D4 expression in the adult and developing rat retina. Experimental Eye Research. 87: 471-7. PMID 18778704 DOI: 10.1016/j.exer.2008.08.004  0.364
2008 Pavlicek J, Coon SL, Ganguly S, Weller JL, Hassan SA, Sackett DL, Klein DC. Evidence that proline focuses movement of the floppy loop of arylalkylamine N-acetyltransferase (EC 2.3.1.87). The Journal of Biological Chemistry. 283: 14552-8. PMID 18362150 DOI: 10.1074/jbc.M800593200  0.326
2007 Ganguly S, Grodzki C, Sugden D, Møller M, Odom S, Gaildrat P, Gery I, Siraganian RP, Rivera J, Klein DC. Neural adrenergic/cyclic AMP regulation of the immunoglobulin E receptor alpha-subunit expression in the mammalian pinealocyte: a neuroendocrine/immune response link? The Journal of Biological Chemistry. 282: 32758-64. PMID 17728245 DOI: 10.1074/Jbc.M705950200  0.355
2007 Muñoz EM, Bailey MJ, Rath MF, Shi Q, Morin F, Coon SL, Møller M, Klein DC. NeuroD1: developmental expression and regulated genes in the rodent pineal gland. Journal of Neurochemistry. 102: 887-99. PMID 17630985 DOI: 10.1111/j.1471-4159.2007.04605.x  0.364
2007 Rath MF, Morin F, Shi Q, Klein DC, Møller M. Ontogenetic expression of the Otx2 and Crx homeobox genes in the retina of the rat. Experimental Eye Research. 85: 65-73. PMID 17467693 DOI: 10.1016/j.exer.2007.02.016  0.304
2007 Humphries A, Wells T, Baler R, Klein DC, Carter DA. Rodent Aanat: intronic E-box sequences control tissue specificity but not rhythmic expression in the pineal gland. Molecular and Cellular Endocrinology. 270: 43-9. PMID 17363136 DOI: 10.1016/J.Mce.2007.02.003  0.341
2007 Hwang Y, Ganguly S, Ho AK, Klein DC, Cole PA. Enzymatic and cellular study of a serotonin N-acetyltransferase phosphopantetheine-based prodrug. Bioorganic & Medicinal Chemistry. 15: 2147-55. PMID 17258461 DOI: 10.1016/J.Bmc.2006.12.016  0.337
2007 Kim JS, Bailey MJ, Ho AK, Møller M, Gaildrat P, Klein DC. Daily rhythm in pineal phosphodiesterase (PDE) activity reflects adrenergic/3',5'-cyclic adenosine 5'-monophosphate induction of the PDE4B2 variant. Endocrinology. 148: 1475-85. PMID 17204557 DOI: 10.1210/en.2006-1420  0.411
2007 Zilberman-Peled B, Appelbaum L, Vallone D, Foulkes NS, Anava S, Anzulovich A, Coon SL, Klein DC, Falcón J, Ron B, Gothilf Y. Transcriptional regulation of arylalkylamine-N-acetyltransferase-2 gene in the pineal gland of the gilthead seabream. Journal of Neuroendocrinology. 19: 46-53. PMID 17184485 DOI: 10.1111/j.1365-2826.2006.01501.x  0.398
2007 Klein DC. Arylalkylamine N-acetyltransferase: "the Timezyme". The Journal of Biological Chemistry. 282: 4233-7. PMID 17164235 DOI: 10.1074/jbc.R600036200  0.366
2006 Pozdeyev N, Taylor C, Haque R, Chaurasia SS, Visser A, Thazyeen A, Du Y, Fu H, Weller J, Klein DC, Iuvone PM. Photic regulation of arylalkylamine N-acetyltransferase binding to 14-3-3 proteins in retinal photoreceptor cells. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 26: 9153-61. PMID 16957072 DOI: 10.1523/Jneurosci.1384-06.2006  0.362
2006 Klein DC. Evolution of the vertebrate pineal gland: the AANAT hypothesis. Chronobiology International. 23: 5-20. PMID 16687276 DOI: 10.1080/07420520500545839  0.371
2006 Rath MF, Muñoz E, Ganguly S, Morin F, Shi Q, Klein DC, Møller M. Expression of the Otx2 homeobox gene in the developing mammalian brain: embryonic and adult expression in the pineal gland. Journal of Neurochemistry. 97: 556-66. PMID 16539656 DOI: 10.1111/j.1471-4159.2006.03773.x  0.333
2006 Vuilleumier R, Besseau L, Boeuf G, Piparelli A, Gothilf Y, Gehring WG, Klein DC, Falcón J. Starting the zebrafish pineal circadian clock with a single photic transition. Endocrinology. 147: 2273-9. PMID 16497800 DOI: 10.1210/en.2005-1565  0.379
2006 Besseau L, Benyassi A, Møller M, Coon SL, Weller JL, Boeuf G, Klein DC, Falcón J. Melatonin pathway: breaking the 'high-at-night' rule in trout retina. Experimental Eye Research. 82: 620-7. PMID 16289161 DOI: 10.1016/j.exer.2005.08.025  0.37
2005 Iuvone PM, Tosini G, Pozdeyev N, Haque R, Klein DC, Chaurasia SS. Circadian clocks, clock networks, arylalkylamine N-acetyltransferase, and melatonin in the retina. Progress in Retinal and Eye Research. 24: 433-56. PMID 15845344 DOI: 10.1016/j.preteyeres.2005.01.003  0.363
2005 Gaildrat P, Møller M, Mukda S, Humphries A, Carter DA, Ganapathy V, Klein DC. A novel pineal-specific product of the oligopeptide transporter PepT1 gene: circadian expression mediated by cAMP activation of an intronic promoter. The Journal of Biological Chemistry. 280: 16851-60. PMID 15684415 DOI: 10.1074/Jbc.M414587200  0.38
2005 Ganguly S, Weller JL, Ho A, Chemineau P, Malpaux B, Klein DC. Melatonin synthesis: 14-3-3-dependent activation and inhibition of arylalkylamine N-acetyltransferase mediated by phosphoserine-205. Proceedings of the National Academy of Sciences of the United States of America. 102: 1222-7. PMID 15644438 DOI: 10.1073/pnas.0406871102  0.302
2005 Zheng W, Schwarzer D, Lebeau A, Weller JL, Klein DC, Cole PA. Cellular stability of serotonin N-acetyltransferase conferred by phosphonodifluoromethylene alanine (Pfa) substitution for Ser-205. The Journal of Biological Chemistry. 280: 10462-7. PMID 15632116 DOI: 10.1074/Jbc.M412283200  0.355
2005 Kim JS, Coon SL, Blackshaw S, Cepko CL, Møller M, Mukda S, Zhao WQ, Charlton CG, Klein DC. Methionine adenosyltransferase:adrenergic-cAMP mechanism regulates a daily rhythm in pineal expression. The Journal of Biological Chemistry. 280: 677-84. PMID 15504733 DOI: 10.1074/jbc.M408438200  0.387
2004 Price DM, Chik CL, Terriff D, Weller J, Humphries A, Carter DA, Klein DC, Ho AK. Mitogen-activated protein kinase phosphatase-1 (MKP-1): >100-fold nocturnal and norepinephrine-induced changes in the rat pineal gland. Febs Letters. 577: 220-6. PMID 15527789 DOI: 10.1016/J.Febslet.2004.09.083  0.4
2004 Humphries A, Weller J, Klein D, Baler R, Carter DA. NGFI-B (Nurr77/Nr4a1) orphan nuclear receptor in rat pinealocytes: Circadian expression involves an adrenergic-cyclic AMP mechanism Journal of Neurochemistry. 91: 946-955. PMID 15525348 DOI: 10.1111/J.1471-4159.2004.02777.X  0.345
2004 Klein DC. The 2004 Aschoff/Pittendrigh lecture: Theory of the origin of the pineal gland--a tale of conflict and resolution. Journal of Biological Rhythms. 19: 264-79. PMID 15245646 DOI: 10.1177/0748730404267340  0.357
2004 Appelbaum L, Toyama R, Dawid IB, Klein DC, Baler R, Gothilf Y. Zebrafish serotonin-N-acetyltransferase-2 gene regulation: pineal-restrictive downstream module contains a functional E-box and three photoreceptor conserved elements. Molecular Endocrinology (Baltimore, Md.). 18: 1210-21. PMID 14988431 DOI: 10.1210/me.2003-0439  0.325
2003 Zheng W, Zhang Z, Ganguly S, Weller JL, Klein DC, Cole PA. Cellular stabilization of the melatonin rhythm enzyme induced by nonhydrolyzable phosphonate incorporation. Nature Structural Biology. 10: 1054-7. PMID 14578935 DOI: 10.1038/Nsb1005  0.349
2003 Chong NW, Chaurasia SS, Haque R, Klein DC, Iuvone PM. Temporal-spatial characterization of chicken clock genes: circadian expression in retina, pineal gland, and peripheral tissues. Journal of Neurochemistry. 85: 851-60. PMID 12716417 DOI: 10.1046/J.1471-4159.2003.01723.X  0.35
2003 Falcón J, Gothilf Y, Coon SL, Boeuf G, Klein DC. Genetic, temporal and developmental differences between melatonin rhythm generating systems in the teleost fish pineal organ and retina. Journal of Neuroendocrinology. 15: 378-82. PMID 12622837 DOI: 10.1046/j.1365-2826.2003.00993.x  0.374
2002 Gothilf Y, Toyama R, Coon SL, Du SJ, Dawid IB, Klein DC. Pineal-specific expression of green fluorescent protein under the control of the serotonin-N-acetyltransferase gene regulatory regions in transgenic zebrafish. Developmental Dynamics : An Official Publication of the American Association of Anatomists. 225: 241-9. PMID 12412006 DOI: 10.1002/dvdy.10152  0.31
2002 Coon SL, Del Olmo E, Young WS, Klein DC. Melatonin synthesis enzymes in Macaca mulatta: focus on arylalkylamine N-acetyltransferase (EC 2.3.1.87). The Journal of Clinical Endocrinology and Metabolism. 87: 4699-706. PMID 12364461 DOI: 10.1210/jc.2002-020683  0.42
2002 Klein DC, Ganguly S, Coon S, Weller JL, Obsil T, Hickman A, Dyda F. 14-3-3 Proteins and photoneuroendocrine transduction: role in controlling the daily rhythm in melatonin. Biochemical Society Transactions. 30: 365-73. PMID 12196096 DOI: 10.1042/Bst0300365  0.371
2002 Schomerus C, Laedtke E, Olcese J, Weller JL, Klein DC, Korf HW. Signal transduction and regulation of melatonin synthesis in bovine pinealocytes: impact of adrenergic, peptidergic and cholinergic stimuli. Cell and Tissue Research. 309: 417-28. PMID 12195298 DOI: 10.1007/S00441-002-0588-X  0.379
2002 Ganguly S, Coon SL, Klein DC. Control of melatonin synthesis in the mammalian pineal gland: the critical role of serotonin acetylation. Cell and Tissue Research. 309: 127-37. PMID 12111543 DOI: 10.1007/s00441-002-0579-y  0.38
2002 Chik CL, Liu Q, Li B, Klein DC, Zylka M, Kim DS, Chin H, Karpinski E, Ho AK. α1D L-Type Ca2+-Channel Currents: Inhibition by a β-Adrenergic Agonist and Pituitary Adenylate Cyclase-Activating Polypeptide (PACAP) in Rat Pinealocytes Journal of Neurochemistry. 68: 1078-1087. DOI: 10.1046/j.1471-4159.1997.68031078.x  0.705
2001 Ganguly S, Mummaneni P, Steinbach PJ, Klein DC, Coon SL. Characterization of the Saccharomyces cerevisiae homolog of the melatonin rhythm enzyme arylalkylamine N-acetyltransferase (EC 2.3.1.87). The Journal of Biological Chemistry. 276: 47239-47. PMID 11559708 DOI: 10.1074/jbc.M107222200  0.33
2001 Ganguly S, Gastel JA, Weller JL, Schwartz C, Jaffe H, Namboodiri MA, Coon SL, Hickman AB, Rollag M, Obsil T, Beauverger P, Ferry G, Boutin JA, Klein DC. Role of a pineal cAMP-operated arylalkylamine N-acetyltransferase/14-3-3-binding switch in melatonin synthesis. Proceedings of the National Academy of Sciences of the United States of America. 98: 8083-8. PMID 11427721 DOI: 10.1073/Pnas.141118798  0.349
2001 Smith M, Burke Z, Humphries A, Wells T, Klein D, Carter D, Baler R. Tissue-specific transgenic knockdown of Fos-related antigen 2 (Fra-2) expression mediated by dominant negative Fra-2 Molecular and Cellular Biology. 21: 3704-3713. PMID 11340164 DOI: 10.1128/Mcb.21.11.3704-3713.2001  0.34
2001 Obsil T, Ghirlando R, Klein DC, Ganguly S, Dyda F. Crystal structure of the 14-3-3zeta:serotonin N-acetyltransferase complex. a role for scaffolding in enzyme regulation. Cell. 105: 257-67. PMID 11336675 DOI: 10.1016/S0092-8674(01)00316-6  0.313
2001 Falcón J, Galarneau KM, Weller JL, Ron B, Chen G, Coon SL, Klein DC. Regulation of arylalkylamine N-acetyltransferase-2 (AANAT2, EC 2.3.1.87) in the fish pineal organ: evidence for a role of proteasomal proteolysis. Endocrinology. 142: 1804-13. PMID 11316744 DOI: 10.1210/endo.142.5.8129  0.421
2001 Coon SL, Weller JL, Korf HW, Namboodiri MA, Rollag M, Klein DC. cAmp regulation of arylalkylamine N-acetyltransferase (AANAT, EC 2.3.1.87): a new cell line (1E7) provides evidence of intracellular AANAT activation. The Journal of Biological Chemistry. 276: 24097-107. PMID 11313340 DOI: 10.1074/jbc.M011298200  0.378
2000 Schomerus C, Korf HW, Laedtke E, Weller JL, Klein DC. Selective adrenergic/cyclic AMP-dependent switch-off of proteasomal proteolysis alone switches on neural signal transduction: an example from the pineal gland. Journal of Neurochemistry. 75: 2123-32. PMID 11032902 DOI: 10.1046/j.1471-4159.2000.0752123.x  0.365
2000 Chong NW, Bernard M, Klein DC. Characterization of the chicken serotonin N-acetyltransferase gene. Activation via clock gene heterodimer/E box interaction. The Journal of Biological Chemistry. 275: 32991-8. PMID 10931848 DOI: 10.1074/jbc.M005671200  0.364
2000 Schwartz WJ, Carpino A, de la Iglesia HO, Baler R, Klein DC, Nakabeppu Y, Aronin N. Differential regulation of fos family genes in the ventrolateral and dorsomedial subdivisions of the rat suprachiasmatic nucleus. Neuroscience. 98: 535-47. PMID 10869847 DOI: 10.1016/S0306-4522(00)00140-8  0.359
2000 Zatz M, Gastel JA, Heath JR, Klein DC. Chick pineal melatonin synthesis: light and cyclic AMP control abundance of serotonin N-acetyltransferase protein. Journal of Neurochemistry. 74: 2315-21. PMID 10820191 DOI: 10.1046/j.1471-4159.2000.0742315.x  0.409
2000 Benyassi A, Schwartz C, Coon SL, Klein DC, Falcón J. Melatonin synthesis: arylalkylamine N-acetyltransferases in trout retina and pineal organ are different. Neuroreport. 11: 255-8. PMID 10674465 DOI: 10.1097/00001756-200002070-00006  0.366
1999 Iuvone PM, Chong NW, Bernard M, Brown AD, Thomas KB, Klein DC. Melatonin biosynthesis in chicken retina. Regulation of tryptophan hydroxylase and arylalkylamine N-acetyltransferase. Advances in Experimental Medicine and Biology. 460: 31-41. PMID 10810497 DOI: 10.1007/0-306-46814-X_4  0.355
1999 Baler R, Covington S, Klein DC. Rat arylalkylamine N-acetyltransferase gene: upstream and intronic components of a bipartite promoter. Biology of the Cell / Under the Auspices of the European Cell Biology Organization. 91: 699-705. PMID 10668100 DOI: 10.1016/S0248-4900(00)88533-0  0.375
1999 Burke Z, Wells T, Carter D, Klein D, Baler R. Genetic targeting: The serotonin N-acetyltransferase promoter imparts circadian expression selectively in the pineal gland and retina of transgenic rats Journal of Neurochemistry. 73: 1343-1349. PMID 10501177 DOI: 10.1046/J.1471-4159.1999.0731343.X  0.372
1999 Gothilf Y, Coon SL, Toyama R, Chitnis A, Namboodiri MA, Klein DC. Zebrafish serotonin N-acetyltransferase-2: marker for development of pineal photoreceptors and circadian clock function. Endocrinology. 140: 4895-903. PMID 10499549 DOI: 10.1210/Endo.140.10.6975  0.387
1999 Bernard M, Guerlotté J, Grève P, Gréchez-Cassiau A, Iuvone MP, Zatz M, Chong NW, Klein DC, Voisin P. Melatonin synthesis pathway: circadian regulation of the genes encoding the key enzymes in the chicken pineal gland and retina. Reproduction, Nutrition, Development. 39: 325-34. PMID 10420435 DOI: 10.1051/Rnd:19990305  0.395
1999 Coon SL, Bégay V, Deurloo D, Falcón J, Klein DC. Two arylalkylamine N-acetyltransferase genes mediate melatonin synthesis in fish. The Journal of Biological Chemistry. 274: 9076-82. PMID 10085157 DOI: 10.1074/jbc.274.13.9076  0.391
1999 Hickman AB, Klein DC, Dyda F. Melatonin biosynthesis: the structure of serotonin N-acetyltransferase at 2.5 A resolution suggests a catalytic mechanism. Molecular Cell. 3: 23-32. PMID 10024876 DOI: 10.1016/S1097-2765(00)80171-9  0.314
1999 Fleming JV, Barrett P, Coon SL, Klein DC, Morgan PJ. Ovine arylalkylamine N-acetyltransferase in the pineal and pituitary glands: differences in function and regulation. Endocrinology. 140: 972-8. PMID 9927331 DOI: 10.1210/endo.140.2.6496  0.34
1998 Roseboom PH, Namboodiri MA, Zimonjic DB, Popescu NC, Rodriguez IR, Gastel JA, Klein DC. Natural melatonin 'knockdown' in C57BL/6J mice: rare mechanism truncates serotonin N-acetyltransferase. Brain Research. Molecular Brain Research. 63: 189-97. PMID 9838107 DOI: 10.1016/S0169-328X(98)00273-3  0.301
1998 Coon SL, Bégay V, Falcón J, Klein DC. Expression of melatonin synthesis genes is controlled by a circadian clock in the pike pineal organ but not in the trout. Biology of the Cell / Under the Auspices of the European Cell Biology Organization. 90: 399-405. PMID 9835014 DOI: 10.1016/S0248-4900(98)80089-0  0.396
1998 Chong NW, Cassone VM, Bernard M, Klein DC, Iuvone PM. Circadian expression of tryptophan hydroxylase mRNA in the chicken retina. Brain Research. Molecular Brain Research. 61: 243-50. PMID 9795235 DOI: 10.1016/S0169-328X(98)00219-8  0.368
1998 Bégay V, Falcón J, Cahill GM, Klein DC, Coon SL. Transcripts encoding two melatonin synthesis enzymes in the teleost pineal organ: circadian regulation in pike and zebrafish, but not in trout. Endocrinology. 139: 905-12. PMID 9492019 DOI: 10.1210/endo.139.3.5790  0.359
1998 Gastel JA, Roseboom PH, Rinaldi PA, Weller JL, Klein DC. Melatonin production: proteasomal proteolysis in serotonin N-acetyltransferase regulation. Science (New York, N.Y.). 279: 1358-60. PMID 9478897 DOI: 10.1126/science.279.5355.1358  0.387
1998 De Angelis J, Gastel J, Klein DC, Cole PA. Kinetic analysis of the catalytic mechanism of serotonin N-acetyltransferase (EC 2.3.1.87). The Journal of Biological Chemistry. 273: 3045-50. PMID 9446620 DOI: 10.1074/Jbc.273.5.3045  0.327
1997 Iuvone PM, Bernard M, Alonso-Gomez A, Greve P, Cassone VM, Klein DC. Cellular and molecular regulation of serotonin N-acetyltransferase activity in chicken retinal photoreceptors. Biological Signals. 6: 217-24. PMID 9500659 DOI: 10.1159/000109131  0.402
1997 Klein DC, Coon SL, Roseboom PH, Weller JL, Bernard M, Gastel JA, Zatz M, Iuvone PM, Rodriguez IR, Bégay V, Falcón J, Cahill GM, Cassone VM, Baler R. The melatonin rhythm-generating enzyme: molecular regulation of serotonin N-acetyltransferase in the pineal gland. Recent Progress in Hormone Research. 52: 307-57; discussion 3. PMID 9238858  0.308
1997 Baler R, Covington S, Klein DC. The rat arylalkylamine N-acetyltransferase gene promoter. cAMP activation via a cAMP-responsive element-CCAAT complex. The Journal of Biological Chemistry. 272: 6979-85. PMID 9054387 DOI: 10.1074/jbc.272.11.6979  0.396
1997 Chik CL, Liu QY, Li B, Klein DC, Zylka M, Kim DS, Chin H, Karpinski E, Ho AK. Alpha 1D L-type Ca(2+)-channel currents: inhibition by a beta-adrenergic agonist and pituitary adenylate cyclase-activating polypeptide (PACAP) in rat pinealocytes. Journal of Neurochemistry. 68: 1078-87. PMID 9048753  0.688
1997 Bernard M, Klein DC, Zatz M. Chick pineal clock regulates serotonin N-acetyltransferase mRNA rhythm in culture. Proceedings of the National Academy of Sciences of the United States of America. 94: 304-9. PMID 8990204 DOI: 10.1073/pnas.94.1.304  0.399
1997 Bernard M, Iuvone PM, Cassone VM, Roseboom PH, Coon SL, Klein DC. Avian melatonin synthesis: photic and circadian regulation of serotonin N-acetyltransferase mRNA in the chicken pineal gland and retina. Journal of Neurochemistry. 68: 213-24. PMID 8978728 DOI: 10.1046/J.1471-4159.1997.68010213.X  0.388
1996 Klein DC, Roseboom PH, Coon SL. New light is shining on the melatonin rhythm enzyme: the first postcloning view. Trends in Endocrinology and Metabolism: Tem. 7: 106-12. PMID 18406734 DOI: 10.1016/1043-2760(96)00033-1  0.392
1996 Bernard M, Voisin P, Klein DC. Hydroxyindole-O-methyltransferase in Y-79 cells: regulation by serum. Brain Research. 727: 118-24. PMID 8842389 DOI: 10.1016/0006-8993(96)00359-9  0.314
1996 Roseboom PH, Coon SL, Baler R, McCune SK, Weller JL, Klein DC. Melatonin synthesis: analysis of the more than 150-fold nocturnal increase in serotonin N-acetyltransferase messenger ribonucleic acid in the rat pineal gland. Endocrinology. 137: 3033-45. PMID 8770929 DOI: 10.1210/endo.137.7.8770929  0.43
1996 Weller JL, Jaffe H, Roseboom PH, Zylka MJ, Klein DC. 2D-PAGE analysis: adrenergically regulated pineal protein AIP 37/6 is a phosphorylated isoform of cytosolic malate dehydrogenase. Brain Research. 713: 8-16. PMID 8724970 DOI: 10.1016/0006-8993(95)01412-8  0.703
1996 Coon SL, Mazuruk K, Bernard M, Roseboom PH, Klein DC, Rodriguez IR. The human serotonin N-acetyltransferase (EC 2.3.1.87) gene (AANAT): structure, chromosomal localization, and tissue expression. Genomics. 34: 76-84. PMID 8661026 DOI: 10.1006/geno.1996.0243  0.375
1996 Baler R, Coon S, Klein DC. Orphan nuclear receptor RZRbeta: cyclic AMP regulates expression in the pineal gland. Biochemical and Biophysical Research Communications. 220: 975-8. PMID 8607878 DOI: 10.1006/bbrc.1996.0517  0.348
1995 Bernard M, Donohue SJ, Klein DC. Human hydroxyindole-O-methyltransferase in pineal gland, retina and Y79 retinoblastoma cells. Brain Research. 696: 37-48. PMID 8574683 DOI: 10.1016/0006-8993(95)00651-6  0.339
1995 Vanecek J, Klein DC. Mechanism of melatonin signal transduction in the neonatal rat pituitary. Neurochemistry International. 27: 273-8. PMID 8520466 DOI: 10.1016/0197-0186(95)00032-4  0.327
1995 Vanecek J, Klein DC. Melatonin inhibition of GnRH-induced LH release from neonatal rat gonadotroph: involvement of Ca2+ not cAMP. The American Journal of Physiology. 269: E85-90. PMID 7631782 DOI: 10.1152/Ajpendo.1995.269.1.E85  0.305
1995 Baler R, Klein DC. Circadian expression of transcription factor Fra-2 in the rat pineal gland. The Journal of Biological Chemistry. 270: 27319-25. PMID 7592994 DOI: 10.1074/jbc.270.45.27319  0.382
1995 Coon SL, Roseboom PH, Baler R, Weller JL, Namboodiri MA, Koonin EV, Klein DC. Pineal serotonin N-acetyltransferase: expression cloning and molecular analysis. Science (New York, N.Y.). 270: 1681-3. PMID 7502081 DOI: 10.1126/Science.270.5242.1681  0.378
1994 Babila T, Klein DC. Cholera toxin-induced Gs alpha down-regulation in neural tissue: studies on the pineal gland. Brain Research. 638: 151-6. PMID 8199855 DOI: 10.1016/0006-8993(94)90644-0  0.309
1994 Roseboom PH, Weller JL, Babila T, Aitken A, Sellers LA, Moffett JR, Namboodiri MA, Klein DC. Cloning and characterization of the epsilon and zeta isoforms of the 14-3-3 proteins. Dna and Cell Biology. 13: 629-40. PMID 8024705 DOI: 10.1089/DNA.1994.13.629  0.343
1994 Lin AM, Schaad NC, Schulz PE, Coon SL, Klein DC. Pineal nitric oxide synthase: characteristics, adrenergic regulation and function. Brain Research. 651: 160-8. PMID 7522930 DOI: 10.1016/0006-8993(94)90693-9  0.357
1993 Vanecek J, Klein DC. A subpopulation of neonatal gonadotropin-releasing hormone-sensitive pituitary cells is responsive to melatonin. Endocrinology. 133: 360-7. PMID 8319582 DOI: 10.1210/endo.133.1.8319582  0.313
1993 White BH, Klein DC. Developmental appearance of pineal adrenergic-->guanosine 3',5'-monophosphate response is determined by a process down-stream from elevation of intracellular Ca2+: possible involvement of a diffusible factor. Endocrinology. 132: 1026-34. PMID 8095011 DOI: 10.1210/endo.132.3.8095011  0.365
1993 Yu L, Schaad NC, Klein DC. Calcium potentiates cyclic AMP stimulation of pineal arylalkylamine N-acetyltransferase. Journal of Neurochemistry. 60: 1436-43. PMID 7681102 DOI: 10.1111/J.1471-4159.1993.Tb03306.X  0.314
1992 Vanecek J, Klein DC. Melatonin inhibits gonadotropin-releasing hormone-induced elevation of intracellular Ca2+ in neonatal rat pituitary cells. Endocrinology. 130: 701-7. PMID 1733718 DOI: 10.1210/endo.130.2.1733718  0.323
1992 Babila T, Schaad NC, Klein DC. Rat pineal Gsa, Gia and Goa: relative abundance and development. Brain Research. 572: 232-5. PMID 1611517 DOI: 10.1016/0006-8993(92)90474-N  0.316
1992 Babila T, Schaad NC, Simonds WF, Shinohara T, Klein DC. Development of MEKA (phosducin), G beta, G gamma and S-antigen in the rat pineal gland and retina. Brain Research. 585: 141-8. PMID 1511297 DOI: 10.1016/0006-8993(92)91199-O  0.383
1992 Korf HW, White BH, Schaad NC, Klein DC. Recoverin in pineal organs and retinae of various vertebrate species including man. Brain Research. 595: 57-66. PMID 1467959 DOI: 10.1016/0006-8993(92)91452-K  0.34
1992 Babila T, Klein DC. Stimulus deprivation increases pineal Gs alpha and G beta. Journal of Neurochemistry. 59: 1356-62. PMID 1402887 DOI: 10.1111/j.1471-4159.1992.tb08448.x  0.364
1992 Weller JL, Klein DC. The pineal adrenergic----cyclic GMP response develops two weeks after the adrenergic----cyclic AMP response. Brain Research. Developmental Brain Research. 68: 144-7. PMID 1325876 DOI: 10.1016/0165-3806(92)90258-X  0.332
1992 Vanecek J, Klein DC. Sodium-dependent effects of melatonin on membrane potential of neonatal rat pituitary cells. Endocrinology. 131: 939-46. PMID 1322288 DOI: 10.1210/endo.131.2.1322288  0.313
1991 Schaad NC, Shinohara T, Abe T, Klein DC. Photoneural control of the synthesis and phosphorylation of pineal MEKA (phosducin). Endocrinology. 129: 3289-98. PMID 1659528 DOI: 10.1210/endo-129-6-3289  0.33
1990 Voisin P, Harrington MG, Weller JL, Goldman D, Merril CR, Klein DC. Noradrenergic control of the synthesis of two rat pineal proteins. Brain Research. 517: 25-34. PMID 2165434 DOI: 10.1016/0006-8993(90)91003-Y  0.366
1989 Ho AK, Chik CL, Klein DC. Forskolin stimulates pinealocyte cGMP accumulation. Dramatic potentiation by an alpha 1-adrenergic----[Ca2+]i mechanism involving protein kinase C. Febs Letters. 249: 207-12. PMID 2544448 DOI: 10.1016/0014-5793(89)80625-8  0.337
1989 McCabe RT, Schoenheimer JA, Skolnick P, Newman AH, Rice KC, Reig JA, Klein DC. [3H]AHN 086 acylates peripheral benzodiazepine receptors in the rat pineal gland. Febs Letters. 244: 263-7. PMID 2537753 DOI: 10.1016/0014-5793(89)80541-1  0.324
1988 Sugden D, Ho AK, Sugden AL, Klein DC. Negative feedback mechanisms: evidence that desensitization of pineal alpha 1-adrenergic responses involves protein kinase-C. Endocrinology. 123: 1425-32. PMID 2841094 DOI: 10.1210/Endo-123-3-1425  0.306
1988 Ho AK, Chik CL, Klein DC. Effects of protein kinase inhibitor (1-(5-isoquinolinesulfonyl)-2-methylpiperazine (H7) on protein kinase C activity and adrenergic stimulation of cAMP and cGMP in rat pinealocytes. Biochemical Pharmacology. 37: 1015-20. PMID 2833269 DOI: 10.1016/0006-2952(88)90503-5  0.316
1988 Chik CL, Ho AK, Klein DC. Dual receptor regulation of cyclic nucleotides: alpha 1-adrenergic potentiation of vasoactive intestinal peptide stimulation of pinealocyte adenosine 3',5'-monophosphate. Endocrinology. 122: 1646-51. PMID 2831037 DOI: 10.1210/endo-122-4-1646  0.322
1988 Sugden D, Klein DC. Activators of protein kinase C act at a postreceptor site to amplify cyclic AMP production in rat pinealocytes. Journal of Neurochemistry. 50: 149-55. PMID 2447232 DOI: 10.1111/J.1471-4159.1988.Tb13242.X  0.313
1987 Ho AK, Klein DC. Phosphatidylinositol phosphodiesterase (phospholipase C) activity in the pineal gland: characterization and photoneural regulation. Journal of Neurochemistry. 48: 1033-8. PMID 3819719 DOI: 10.1111/J.1471-4159.1987.Tb05622.X  0.313
1987 Yanovski J, Witcher J, Adler N, Markey SP, Klein DC. Stimulation of the paraventricular nucleus area of the hypothalamus elevates urinary 6-hydroxymelatonin during daytime. Brain Research Bulletin. 19: 129-33. PMID 3651836 DOI: 10.1016/0361-9230(87)90175-4  0.318
1987 Namboodiri MA, Brownstein MJ, Weller J, Voisin P, Klein DC. Multiple forms of arylalkylamine N-acetyltransferases in the rat pineal gland: purification of one molecular form. Journal of Pineal Research. 4: 235-46. PMID 3625455 DOI: 10.1111/J.1600-079X.1987.Tb00861.X  0.316
1987 Ho AK, Chik CL, Klein DC. Transmembrane receptor cross-talk: concurrent VIP and alpha 1-adrenergic activation rapidly elevates pinealocyte cGMP greater than 100-fold. Biochemical and Biophysical Research Communications. 146: 1478-84. PMID 3040005 DOI: 10.1016/0006-291X(87)90816-3  0.358
1986 Ho AK, Somers RL, Klein DC. Development and regulation of rhodopsin kinase in rat pineal and retina. Journal of Neurochemistry. 46: 1176-9. PMID 3950623 DOI: 10.1111/J.1471-4159.1986.Tb00634.X  0.382
1986 Sugden D, Voisin P, Klein DC. Purification of rat pineal hydroxyindole-O-methyltransferase using S-adenosyl-L-homocysteine agarose chromatography. Journal of Pineal Research. 3: 389-95. PMID 3783420 DOI: 10.1111/j.1600-079X.1986.tb00761.x  0.308
1986 Vanecek J, Sugden D, Weller JL, Klein DC. See-saw signal processing in pinealocytes involves reciprocal changes in the alpha 1-adrenergic component of the cyclic GMP response and the beta-adrenergic component of the cyclic AMP response. Journal of Neurochemistry. 47: 678-86. PMID 3016179 DOI: 10.1111/j.1471-4159.1986.tb00665.x  0.316
1985 Namboodiri MA, Sugden D, Klein DC, Tamarkin L, Mefford IN. Serum melatonin and pineal indoleamine metabolism in a species with a small day/night N-acetyltransferase rhythm. Comparative Biochemistry and Physiology. B, Comparative Biochemistry. 80: 731-6. PMID 3995918 DOI: 10.1016/0305-0491(85)90453-5  0.39
1985 Klein DC, Voisin P, Namboodiri MA. The pineal family of aromatic amine N-acetyltransferases. Bioessays : News and Reviews in Molecular, Cellular and Developmental Biology. 3: 217-20. PMID 3842594 DOI: 10.1002/bies.950030508  0.325
1985 Vanecek J, Sugden D, Weller J, Klein DC. Atypical synergistic alpha 1- and beta-adrenergic regulation of adenosine 3',5'-monophosphate and guanosine 3',5'-monophosphate in rat pinealocytes. Endocrinology. 116: 2167-73. PMID 2986940 DOI: 10.1210/endo-116-6-2167  0.321
1985 Sugden D, Vanecek J, Klein DC, Thomas TP, Anderson WB. Activation of protein kinase C potentiates isoprenaline-induced cyclic AMP accumulation in rat pinealocytes. Nature. 314: 359-61. PMID 2984573 DOI: 10.1038/314359A0  0.34
1985 Sugden D, Klein DC. Regulation of rat pineal alpha 1-adrenoceptors. Journal of Neurochemistry. 44: 63-7. PMID 2856885 DOI: 10.1111/j.1471-4159.1985.tb07113.x  0.357
1985 Namboodiri MA, Sugden D, Klein DC, Grady R, Mefford IN. Rapid nocturnal increase in ovine pineal N-acetyltransferase activity and melatonin synthesis: effects of cycloheximide. Journal of Neurochemistry. 45: 832-5. PMID 2411856 DOI: 10.1111/J.1471-4159.1985.Tb04069.X  0.334
1984 Klein DC. Melatonin and puberty. Science (New York, N.Y.). 224: 6. PMID 6701534 DOI: 10.1126/Science.6701534  0.331
1984 Rollag MD, Welsh MG, Klein DC. Effect of acute light exposure upon melatonin content, NAT activity, and nuclear volume in the gerbil pineal complex. Journal of Pineal Research. 1: 339-47. PMID 6545826 DOI: 10.1111/J.1600-079X.1984.Tb00224.X  0.398
1984 Reppert SM, Perlow MJ, Artman HG, Ungerleider LG, Fisher DA, Klein DC. The circadian rhythm of oxytocin in primate cerebrospinal fluid: effects of destruction of the suprachiasmatic nuclei. Brain Research. 307: 384-7. PMID 6467006 DOI: 10.1016/0006-8993(84)90501-8  0.562
1984 Klein DC, Somers R. Presence of rhodopsin kinase in the rat pineal gland Journal of Steroid Biochemistry. 20: 1455. DOI: 10.1016/0022-4731(84)90596-X  0.309
1983 Sugden D, Klein DC. Regulation of rat pineal hydroxyindole-O-methyltransferase in neonatal and adult rats. Journal of Neurochemistry. 40: 1647-53. PMID 6854324 DOI: 10.1111/J.1471-4159.1983.Tb08138.X  0.375
1983 Sugden D, Klein DC. Adrenergic stimulation of rat pineal hydroxyindole-O-methyltransferase. Brain Research. 265: 348-51. PMID 6850338 DOI: 10.1016/0006-8993(83)90355-4  0.348
1983 Klein DC, Smoot R, Weller JL, Higa S, Markey SP, Creed GJ, Jacobowitz DM. Lesions of the paraventricular nucleus area of the hypothalamus disrupt the suprachiasmatic leads to spinal cord circuit in the melatonin rhythm generating system. Brain Research Bulletin. 10: 647-52. PMID 6307491 DOI: 10.1016/0361-9230(83)90033-3  0.316
1983 Sugden D, Klein DC. Beta-adrenergic receptor control of rat pineal hydroxyindole-O-methyltransferase. Endocrinology. 113: 348-53. PMID 6305637 DOI: 10.1210/endo-113-1-348  0.354
1983 Mefford IN, Chang P, Klein DC, Namboodiri MA, Sugden D, Barchas J. Reciprocal day/night relationship between serotonin oxidation and N-acetylation products in the rat pineal gland. Endocrinology. 113: 1582-6. PMID 6194975 DOI: 10.1210/Endo-113-5-1582  0.309
1983 Klein DC, Sugden D, Weller JL. Postsynaptic alpha-adrenergic receptors potentiate the beta-adrenergic stimulation of pineal serotonin N-acetyltransferase. Proceedings of the National Academy of Sciences of the United States of America. 80: 599-603. PMID 6132380 DOI: 10.1073/Pnas.80.2.599  0.323
1982 Klein DC, Namboodiri M. Control of the circadian rhythm in pineal serotonin N-acetyltransferase activity: possible role of protein thiol: disulfide exchange Trends in Biochemical Sciences. 7: 98-102. DOI: 10.1016/0968-0004(82)90156-6  0.37
1981 Reppert SM, Perlow MJ, Ungerleider LG, Mishkin M, Tamarkin L, Orloff DG, Hoffman HJ, Klein DC. Effects of damage to the suprachiasmatic area of the anterior hypothalamus on the daily melatonin and cortisol rhythms in the rhesus monkey. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 1: 1414-25. PMID 7320754 DOI: 10.1523/Jneurosci.01-12-01414.1981  0.588
1981 Reppert SM, Perlow MJ, Tamarkin L, Orloff D, Klein DC. The effects of environmental lighting on the daily melatonin rhythm in primate cerebrospinal fluid. Brain Research. 223: 313-23. PMID 7284813 DOI: 10.1016/0006-8993(81)91144-6  0.585
1981 Perlow MJ, Reppert SM, Boyar RM, Klein DC. Daily rhythms in cortisol and melatonin in primate cerebrospinal fluid. Effects of constant light and dark. Neuroendocrinology. 32: 193-6. PMID 7194425 DOI: 10.1159/000123157  0.581
1981 Klein DC, Auerbach DA, Weller JL. Seesaw signal processing in pineal cells: homologous sensitization of adrenergic stimulation of cyclic GMP accompanies homologous desensitization of beta-adrenergic stimulation of cyclic AMP. Proceedings of the National Academy of Sciences of the United States of America. 78: 4625-9. PMID 6270688 DOI: 10.1073/Pnas.78.7.4625  0.343
1981 Klein DC, Namboodiri MA, Auerbach DA. The melatonin rhythm generating system: developmental aspects. Life Sciences. 28: 1975-86. PMID 6264261 DOI: 10.1016/0024-3205(81)90644-5  0.315
1981 Kapatos G, Kaufman S, Weller JL, Klein DC. Biosynthesis of biopterin: adrenergic cyclic adenosine monophosphate-dependent inhibition in the pineal gland. Science (New York, N.Y.). 213: 1129-31. PMID 6168019 DOI: 10.1126/Science.6168019  0.329
1980 Tamarkin L, Reppert SM, Klein DC, Pratt B, Goldman BD. Studies on the daily pattern of pineal melatonin in the Syrian hamster. Endocrinology. 107: 1525-9. PMID 7428680 DOI: 10.1210/Endo-107-5-1525  0.604
1980 Tamarkin L, Reppert SM, Orloff DJ, Klein DC, Yellon SM, Goldman BD. Ontogeny of the pineal melatonin rhythm in the Syrian (Mesocricetus auratus) and Siverian (Phodopus sungorus) hamsters and in the rat. Endocrinology. 107: 1061-4. PMID 7408759 DOI: 10.1210/Endo-107-4-1061  0.6
1980 Martin JE, McKellar S, Klein DC. Melatonin inhibition of the in vivo pituitary response to luteinizing hormone-releasing hormone in the neonatal rat. Neuroendocrinology. 31: 13-7. PMID 6993981 DOI: 10.1159/000123044  0.361
1980 Martin JE, Kirk KL, Klein DC. Effects of 6-hydroxy-, 6-fluoro-, and 4,6-difluoromelatonin on the in vitro pituitary response to luteinizing hormone-releasing hormone. Endocrinology. 106: 398-401. PMID 6985588 DOI: 10.1210/endo-106-1-398  0.341
1980 Perlow MJ, Reppert SM, Tamarkin L, Wyatt RJ, Klein DC. Photic regulation of the melatonin rhythm: monkey and man are not the same. Brain Research. 182: 211-6. PMID 6766079 DOI: 10.1016/0006-8993(80)90848-3  0.575
1980 Namboodiri MA, Weller JL, Klein DC. Rapid and reversible activation of acetyl CoA hydrolase in intact pineal cells by disulfide exchange. Biochemical and Biophysical Research Communications. 96: 188-95. PMID 6108107 DOI: 10.1016/0006-291X(80)91199-7  0.32
1979 Klein DC, Moore RY. Pineal N-acetyltransferase and hydroxyindole-O-methyltransferase: control by the retinohypothalamic tract and the suprachiasmatic nucleus. Brain Research. 174: 245-62. PMID 487129 DOI: 10.1016/0006-8993(79)90848-5  0.345
1979 Tamarkin L, Reppert SM, Klein DC. Regulation of pineal melatonin in the Syrian hamster. Endocrinology. 104: 385-9. PMID 446367 DOI: 10.1210/endo-104-2-385  0.594
1979 Wheler GH, Weller JL, Klein DC. Taurine: stimulation of pineal N-acetyltransferase activity and melatonin production via a beta-adrenergic mechanism. Brain Research. 166: 65-74. PMID 217502 DOI: 10.1016/0006-8993(79)90650-4  0.345
1979 Reppert SM, Chez RA, Anderson A, Klein DC. Maternal-fetal transfer of melatonin in the non-human primate. Pediatric Research. 13: 788-91. PMID 113767 DOI: 10.1203/00006450-197906000-00015  0.561
1979 Reppert SM, Perlow MJ, Tamarkin L, Klein DC. A diurnal melatonin rhythm in primate cerebrospinal fluid. Endocrinology. 104: 295-301. PMID 109277 DOI: 10.1210/endo-104-2-295  0.571
1979 Namboodiri MA, Favilla JT, Klein DC. Activation of pineal and brain acetyl-COA hydrolase by cystamine: an apparent case of disulfide exchange. Biochemical and Biophysical Research Communications. 91: 1166-73. PMID 43149 DOI: 10.1016/0006-291X(79)92002-3  0.321
1979 Namboodiri MA, Namboodiri MA, Weller JL, Klein DC. A comparative study of pineal acetyl-CoA hydrolase and N-acetyltransferase activities. Journal of Neurochemistry. 32: 31-3. PMID 32232 DOI: 10.1111/J.1471-4159.1979.Tb04506.X  0.374
1978 Buda M, Klein DC. A suspension culture of pinealocytes: regulation of N-acetyltransferase activity. Endocrinology. 103: 1483-93. PMID 744160 DOI: 10.1210/endo-103-4-1483  0.361
1978 Reppert SM, Klein DC. Transport of maternal[3H]melatonin to suckling rats and the fate of [3H]melatonin in the neonatal rat. Endocrinology. 102: 582-8. PMID 743980 DOI: 10.1210/endo-102-2-582  0.576
1978 Reppert SM, Chez RA, Klein DC. Maternal-fetal transfer of melatonin in the nonhuman primate Pediatric Research. 12: No. 331.  0.449
1977 Yuwiler A, Klein DC, Buda M, Weller JL. Adrenergic control of pineal N-acetyltransferase activity: developmental aspects. The American Journal of Physiology. 233: E141-6. PMID 910899 DOI: 10.1152/Ajpendo.1977.233.3.E141  0.387
1977 Martin JE, Engel JN, Klein DC. Inhibition of the in vitro pituitary response to luteinizing hormone-releasing hormone by melatonin, serotonin, and 5-methoxytryptamine. Endocrinology. 100: 675-80. PMID 401360 DOI: 10.1210/Endo-100-3-675  0.334
1977 Reppert SM, Klein DC, Schulman JD. MILK TRANSPORT OF |[lsqb]|3H|[rsqb]|MELATONIN TO SUCKLING RATS Pediatric Research. 11: 420-420. DOI: 10.1203/00006450-197704000-00306  0.57
1977 Reppert SM, Klein DC. Milk transport of [3H]melatonin to suckling rats Pediatric Research. 11: No.292.  0.5
1976 Chen CH, Klein DC, Robinson JC. Monoamine oxidase in rat placenta, human placenta, and cultured choriocarcinoma. Journal of Reproduction and Fertility. 46: 477-9. PMID 1255585 DOI: 10.1530/Jrf.0.0460477  0.332
1976 Martin JE, Klein DC. Melatonin inhibition of the neonatal pituitary response to luteinizing hormone-releasing factor. Science (New York, N.Y.). 191: 301-2. PMID 1108199 DOI: 10.1126/Science.1108199  0.327
1976 Parfitt AG, Klein DC. Sympathetic nerve endings in the pineal gland protect against acute stress-induced increase in N-acetyltransferase (EC 2.3.1.5.) activity. Endocrinology. 99: 840-51. PMID 954673 DOI: 10.1210/endo-99-3-840  0.347
1976 Martin JE, Klein DC. Long-term organ culture of rat anterior pituitary glands. Endocrinology. 99: 1189-98. PMID 791638 DOI: 10.1210/endo-99-5-1189  0.344
1976 Parfitt A, Weller JL, Klein DC. Beta adrenergic-blockers decrease adrenergically stimulated N-acetyltransferase activity in pineal glands in organ culture. Neuropharmacology. 15: 353-8. PMID 6923 DOI: 10.1016/0028-3908(76)90083-6  0.338
1975 Ralph CL, Binkley S, MacBride SE, Klein DC. Regulation of pineal rhythms in chickens: effects of blinding, constant light, constant dark, and superior cervical ganglionectomy. Endocrinology. 97: 1373-8. PMID 1239366 DOI: 10.1210/endo-97-6-1373  0.371
1975 Binkley S, Macbride SE, Klein DC, Ralph CL. Regulation of pineal rhythms in chickens: refractory period and nonvisual light perception. Endocrinology. 96: 848-53. PMID 1120473 DOI: 10.1210/endo-96-4-848  0.389
1974 Moore RY, Klein DC. Visual pathways and the central neural control of a circadian rhythm in pineal serotonin N-acetyltransferase activity. Brain Research. 71: 17-33. PMID 4595289 DOI: 10.1016/0006-8993(74)90188-7  0.362
1974 Bensinger RE, Klein DC, Weller JL, Lovenberg W. Radiometric assay of total tryptophan hydroxylation by intact cultured pineal glands. Journal of Neurochemistry. 23: 111-7. PMID 4546896 DOI: 10.1111/J.1471-4159.1974.Tb06923.X  0.327
1974 Schrier BK, Klein DC. Absence of choline acetyltransferase in rat and rabbit pineal gland. Brain Research. 79: 347-51. PMID 4422287 DOI: 10.1016/0006-8993(74)90431-4  0.327
1974 Chen CH, Klein DC, Robinson JC. Catechol-O-methyltransferase in rat placenta, human placenta and choriocarcinoma grown in culture. Journal of Reproduction and Fertility. 39: 407-10. PMID 4412347 DOI: 10.1530/Jrf.0.0390407  0.317
1973 Ulrich R, Yuwiler A, Wetterberg L, Klein D. Effects of light and temperature on the pineal gland in suckling rats. Neuroendocrinology. 13: 255-63. PMID 4779326 DOI: 10.1159/000122210  0.345
1973 Binkley SA, Klein DC, Weller JL. Dark induced increase in pineal serotonin N-acetyltransferase activity: a refractory period. Experientia. 29: 1339-40. PMID 4761229 DOI: 10.1007/Bf01922804  0.334
1973 Klein DC, Yuwiler A, Weller JL, Plotkin S. Postsynaptic adrenergic-cyclic AMP control of the serotonin content of cultured rat pineal glands. Journal of Neurochemistry. 21: 1261-71. PMID 4357502 DOI: 10.1111/J.1471-4159.1973.Tb07580.X  0.321
1973 Binkley S, Macbride SE, Klein DC, Ralph CL. Pineal Enzymes: Regulation of Avian Melatonin Synthesis Science. 181: 273-275. DOI: 10.1126/science.181.4096.273-a  0.381
1973 Klein DC, Yuwiler A, Bensinger R. Beta adrenergic regulation of serotonin in the cultured rat pineal gland Life Sciences. 13: LXXXVI-LXXXVII. DOI: 10.1016/0024-3205(73)90310-X  0.32
1972 Klein DC, Weller JL. Rapid light-induced decrease in pineal serotonin N-acetyltransferase activity. Science (New York, N.Y.). 177: 532-3. PMID 5050487 DOI: 10.1126/Science.177.4048.532  0.395
1972 Ellison N, Weller JL, Klein DC. Development of a circadian rhythm in the activity of pineal serotonin N-acetyltransferase. Journal of Neurochemistry. 19: 1335-41. PMID 5025129 DOI: 10.1111/J.1471-4159.1972.Tb01458.X  0.402
1972 Klein DC. Evidence for the placental transfer of 3 H-acetyl-melatonin. Nature: New Biology. 237: 117-8. PMID 4503849 DOI: 10.1038/Newbio237117A0  0.364
1972 Strada SJ, Klein DC, Weller J, Weiss B. Effect of norepinephrine on the concentration of adenosine 3',5'-monophosphate of rat pineal gland in organ culture. Endocrinology. 90: 1470-5. PMID 4401741 DOI: 10.1210/endo-90-6-1470  0.348
1972 Klein DC, Weller J. Input and output signals in a model neural system: the regulation of melatonin production in the pineal gland. In Vitro. 6: 197-204. PMID 4331703 DOI: 10.1007/BF02617764  0.367
1972 Silberstein SD, Lemberger L, Klein DC, Axelrod J, Kopin IJ. Induction of adrenal tyrosine hydroxylase in organ culture. Neuropharmacology. 11: 721-6. PMID 4151251 DOI: 10.1016/0028-3908(72)90081-0  0.325
1971 Klein DC, Reiter RJ, Weller JL. Pineal N-acetyltransferase activity in blinded and anosmic male rats. Endocrinology. 89: 1020-3. PMID 5092653 DOI: 10.1210/endo-89-4-1020  0.348
1971 Klein DC, Weller JL, Moore RY. Melatonin metabolism: neural regulation of pineal serotonin: acetyl coenzyme A N-acetyltransferase activity. Proceedings of the National Academy of Sciences of the United States of America. 68: 3107-10. PMID 4332009 DOI: 10.1073/Pnas.68.12.3107  0.396
1971 Berg GR, Klein DC. Pineal gland in organ culture. II. Role of adenosine 3',5'-monophosphate in the regulation of radiolabeled melatonin production. Endocrinology. 89: 453-64. PMID 4326791 DOI: 10.1210/endo-89-2-453  0.362
1971 Reiter RJ, Klein DC. Observations on the pineal gland, the Harderian glands, the retina, and the reproductive organs of adult female rats exposed to continuous light. The Journal of Endocrinology. 51: 117-25. PMID 4108164 DOI: 10.1677/Joe.0.0510117  0.334
1970 Rowe JW, Richert JR, Klein DC, Reichlin S. Relation of the pineal gland and environmental lighting to thyroid function in the rat. Neuroendocrinology. 6: 247-54. PMID 5473375 DOI: 10.1159/000121930  0.344
1970 Klein DC, Weller JL. Indole metabolism in the pineal gland: a circadian rhythm in N-acetyltransferase. Science (New York, N.Y.). 169: 1093-5. PMID 4915470 DOI: 10.1126/science.169.3950.1093  0.409
1970 Klein DC, Berg GR, Weller J. Melatonin synthesis: adenosine 3',5'-monophosphate and norepinephrine stimulate N-acetyltransferase. Science (New York, N.Y.). 168: 979-80. PMID 4314985 DOI: 10.1126/science.168.3934.979  0.351
1970 Klein DC, Berg GR, Weller J, Glinsmann W. Pineal gland: dibutyryl cyclic adenosine monophosphate stimulation of labeled melatonin production. Science (New York, N.Y.). 167: 1738-40. PMID 4313580 DOI: 10.1126/science.167.3926.1738  0.325
1969 Klein DC, Lines SV. Pineal hydroxyindole-O-methyl transferase activity in the growing rat. Endocrinology. 84: 1523-5. PMID 5781132 DOI: 10.1210/endo-84-6-1523  0.348
Low-probability matches (unlikely to be authored by this person)
1984 Voisin P, Goldman D, Weller J, Merri C, Klein D. Identification of an adrenergically induced protein (aip 37k/5.8) in the rat pineal gland Journal of Steroid Biochemistry. 20: 1472. DOI: 10.1016/0022-4731(84)90629-0  0.3
1987 Ho AK, Ceña V, Klein DC. Cardiac glycosides stimulate phospholipase C activity in rat pinealocytes. Biochemical and Biophysical Research Communications. 142: 819-25. PMID 3030302 DOI: 10.1016/0006-291X(87)91487-2  0.3
1984 Somers RL, Klein DC. Rhodopsin kinase activity in the mammalian pineal gland and other tissues. Science (New York, N.Y.). 226: 182-4. PMID 6091271 DOI: 10.1126/Science.6091271  0.299
2006 Coon SL, Klein DC. Evolution of arylalkylamine N-acetyltransferase: emergence and divergence. Molecular and Cellular Endocrinology. 252: 2-10. PMID 16697105 DOI: 10.1016/j.mce.2006.03.039  0.299
1976 Mata MM, Schrier BK, Klein DC, Weller JL, Chiou CY. On GABA function and physiology in the pineal gland. Brain Research. 118: 383-94. PMID 1009426 DOI: 10.1016/0006-8993(76)90306-1  0.299
1988 Chik CL, Ho AK, Klein DC. Alpha 1-adrenergic potentiation of vasoactive intestinal peptide stimulation of rat pinealocyte adenosine 3',5'-monophosphate and guanosine 3',5'-monophosphate: evidence for a role of calcium and protein kinase-C. Endocrinology. 122: 702-8. PMID 2892667 DOI: 10.1210/endo-122-2-702  0.298
1977 Parfitt A, Klein DC. Increase caused by desmethylimipramine in the production of [3H]melatonin by isolated pineal glands. Biochemical Pharmacology. 26: 904-5. PMID 861059 DOI: 10.1016/0006-2952(77)90412-9  0.298
1972 Lott IT, Quarles RH, Klein DC. Biosynthesis and release of glycoproteins by pineal gland in organ culture. Biochimica Et Biophysica Acta. 264: 144-51. PMID 5063204 DOI: 10.1016/0304-4165(72)90125-0  0.298
2010 Rovsing L, Rath MF, Lund-Andersen C, Klein DC, Møller M. A neuroanatomical and physiological study of the non-image forming visual system of the cone-rod homeobox gene (Crx) knock out mouse. Brain Research. 1343: 54-65. PMID 20438719 DOI: 10.1016/j.brainres.2010.04.066  0.298
2003 Klein DC, Ganguly S, Coon SL, Shi Q, Gaildrat P, Morin F, Weller JL, Obsil T, Hickman A, Dyda F. 14-3-3 proteins in pineal photoneuroendocrine transduction: how many roles? Journal of Neuroendocrinology. 15: 370-7. PMID 12622836 DOI: 10.1046/J.1365-2826.2003.01000.X  0.296
1981 Auerbach DA, Klein DC, Woodard C, Aurbach GD. Neonatal rat pinealocytes: typical and atypical characteristics of [125I]iodohydroxybenzylpindolol binding and adenosine 3',5'-monophosphate accumulation. Endocrinology. 108: 559-67. PMID 6256156 DOI: 10.1210/Endo-108-2-559  0.296
1989 Nikodijevic O, Klein DC. Adenosine stimulates adenosine 3',5'-monophosphate and guanosine 3',5'-monophosphate accumulation in rat pinealocytes: evidence for a role for adenosine in pineal neurotransmission. Endocrinology. 125: 2150-7. PMID 2551639 DOI: 10.1210/endo-125-4-2150  0.296
1980 Wheler GH, Klein DC. Taurine release from the pineal-gland is stimulated via a beta-adrenergic mechanism. Brain Research. 187: 155-64. PMID 6244066 DOI: 10.1016/0006-8993(80)90501-6  0.296
1985 Sugden D, Klein DC. Development of the rat pineal alpha 1-adrenoceptor. Brain Research. 325: 345-8. PMID 2983831 DOI: 10.1016/0006-8993(85)90337-3  0.295
1984 Sugden D, Weller JL, Klein DC, Kirk KL, Creveling CR. Alpha-adrenergic potentiation of beta-adrenergic stimulation of rat pineal N-acetyltransferase. Studies using cirazoline and fluorine analogs of norepinephrine. Biochemical Pharmacology. 33: 3947-50. PMID 6150711 DOI: 10.1016/0006-2952(84)90006-6  0.295
1988 Ho AK, Chik CL, Klein DC. Permissive role of calcium in alpha 1-adrenergic stimulation of pineal phosphatidylinositol phosphodiesterase (phospholipase C) activity. Journal of Pineal Research. 5: 553-64. PMID 2906366 DOI: 10.1111/J.1600-079X.1988.Tb00798.X  0.295
1999 Coon SL, Zarazaga LA, Malpaux B, Ravault JP, Bodin L, Voisin P, Weller JL, Klein DC, Chemineau P. Genetic variability in plasma melatonin in sheep is due to pineal weight, not to variations in enzyme activities. The American Journal of Physiology. 277: E792-7. PMID 10567004 DOI: 10.1152/Ajpendo.1999.277.5.E792  0.295
2009 Alon S, Eisenberg E, Jacob-Hirsch J, Rechavi G, Vatine G, Toyama R, Coon SL, Klein DC, Gothilf Y. A new cis-acting regulatory element driving gene expression in the zebrafish pineal gland. Bioinformatics (Oxford, England). 25: 559-62. PMID 19147662 DOI: 10.1093/Bioinformatics/Btp031  0.294
1972 Berg GR, Klein DC. Norepinephrine increases the (32P)labelling of a specific phospholipid frac tion of post-synaptic pineal membranes. Journal of Neurochemistry. 19: 2519-32. PMID 4263895 DOI: 10.1111/J.1471-4159.1972.Tb01311.X  0.293
2010 Klein DC, Bailey MJ, Carter DA, Kim JS, Shi Q, Ho AK, Chik CL, Gaildrat P, Morin F, Ganguly S, Rath MF, Møller M, Sugden D, Rangel ZG, Munson PJ, et al. Pineal function: impact of microarray analysis. Molecular and Cellular Endocrinology. 314: 170-83. PMID 19622385 DOI: 10.1016/J.Mce.2009.07.010  0.293
1987 Namboodiri MA, Brownstein MJ, Voisin P, Weller JL, Klein DC. A simple and rapid method for the purification of ovine pineal arylalkylamine N-acetyltransferase. Journal of Neurochemistry. 48: 580-5. PMID 3794723 DOI: 10.1111/j.1471-4159.1987.tb04132.x  0.293
1986 Basile AS, Klein DC, Skolnick P. Characterization of benzodiazepine receptors in the bovine pineal gland: evidence for the presence of an atypical binding site. Brain Research. 387: 127-35. PMID 3024779 DOI: 10.1016/0169-328X(86)90004-5  0.292
1969 Reiter RJ, Klein DC, Donofrio RJ. Preliminary observations on the reproductive effects of the pineal gland in blinded, anosmic male rats. Journal of Reproduction and Fertility. 19: 563-5. PMID 5809475 DOI: 10.1530/JRF.0.0190563  0.292
1989 Abe T, Yamaki K, Tsuda M, Singh VK, Suzuki S, McKinnon R, Klein DC, Donoso LA, Shinohara T. Rat pineal S-antigen: sequence analysis reveals presence of alpha-transducin homologous sequence. Febs Letters. 247: 307-11. PMID 2714438 DOI: 10.1016/0014-5793(89)81358-4  0.291
1995 White BH, Klein DC. Stimulation of cyclic GMP accumulation by sodium nitroprusside is potentiated via a Gs mechanism in intact pinealocytes. Journal of Neurochemistry. 64: 711-7. PMID 7830064 DOI: 10.1046/J.1471-4159.1995.64020711.X  0.291
1984 Weissman BA, Skolnick P, Klein DC. Regulation of "peripheral-type" binding sites for benzodiazepines in the pineal gland. Pharmacology, Biochemistry, and Behavior. 21: 821-4. PMID 6097917 DOI: 10.1016/S0091-3057(84)80059-3  0.29
1999 Hickman AB, Namboodiri MA, Klein DC, Dyda F. The structural basis of ordered substrate binding by serotonin N-acetyltransferase: enzyme complex at 1.8 A resolution with a bisubstrate analog. Cell. 97: 361-9. PMID 10319816 DOI: 10.1016/S0092-8674(00)80745-X  0.29
2007 Szewczuk LM, Saldanha SA, Ganguly S, Bowers EM, Javoroncov M, Karanam B, Culhane JC, Holbert MA, Klein DC, Abagyan R, Cole PA. De novo discovery of serotonin N-acetyltransferase inhibitors. Journal of Medicinal Chemistry. 50: 5330-8. PMID 17924613 DOI: 10.1021/Jm0706463  0.288
1996 Bernard M, Klein DC. Retinoic acid increases hydroxyindole-O-methyltransferase activity and mRNA in human Y-79 retinoblastoma cells. Journal of Neurochemistry. 67: 1032-8. PMID 8752109 DOI: 10.1046/J.1471-4159.1996.67031032.X  0.288
1992 Schaad NC, Klein DC. Characterization of alpha 2-adrenergic receptors on rat pinealocytes. Endocrinology. 130: 2804-10. PMID 1315259 DOI: 10.1210/endo.130.5.1315259  0.286
1985 Sugden D, Namboodiri MA, Klein DC, Grady RK, Mefford IN. Ovine pineal indoles: effects of L-tryptophan or L-5-hydroxytryptophan administration. Journal of Neurochemistry. 44: 769-72. PMID 3871838 DOI: 10.1111/J.1471-4159.1985.Tb12881.X  0.286
1986 van Veen T, Ostholm T, Gierschik P, Spiegel A, Somers R, Korf HW, Klein DC. alpha-Transducin immunoreactivity in retinae and sensory pineal organs of adult vertebrates. Proceedings of the National Academy of Sciences of the United States of America. 83: 912-6. PMID 3513166 DOI: 10.1073/Pnas.83.4.912  0.285
2004 Iyer LM, Aravind L, Coon SL, Klein DC, Koonin EV. Evolution of cell-cell signaling in animals: did late horizontal gene transfer from bacteria have a role? Trends in Genetics : Tig. 20: 292-9. PMID 15219393 DOI: 10.1016/j.tig.2004.05.007  0.285
2002 Iuvone PM, Brown AD, Haque R, Weller J, Zawilska JB, Chaurasia SS, Ma M, Klein DC. Retinal melatonin production: role of proteasomal proteolysis in circadian and photic control of arylalkylamine N-acetyltransferase. Investigative Ophthalmology & Visual Science. 43: 564-72. PMID 11818405  0.285
1983 Namboodiri MA, Sugden D, Klein DC, Mefford IN. 5-hydroxytryptophan elevates serum melatonin. Science (New York, N.Y.). 221: 659-61. PMID 6867734 DOI: 10.1126/Science.6867734  0.285
2000 Dyda F, Klein DC, Hickman AB. GCN5-related N-acetyltransferases: a structural overview. Annual Review of Biophysics and Biomolecular Structure. 29: 81-103. PMID 10940244 DOI: 10.1146/annurev.biophys.29.1.81  0.284
1984 Sugden D, Klein DC. Inactivation of rat pineal hydroxyindole-o-methyltransferase by disulfides: evidence for an endogenous inactivator Journal of Steroid Biochemistry. 20: 1469. DOI: 10.1016/0022-4731(84)90624-1  0.283
1984 Sugden D, Klein DC. Rat pineal alpha 1-adrenoceptors: identification and characterization using [125I]iodo-2-[beta-(4-hydroxyphenyl)-ethylaminomethyl]tetralone. Endocrinology. 114: 435-40. PMID 6140159 DOI: 10.1210/endo-114-2-435  0.283
2011 Davies JS, Klein DC, Carter DA. Selective genomic targeting by FRA-2/FOSL2 transcription factor: regulation of the Rgs4 gene is mediated by a variant activator protein 1 (AP-1) promoter sequence/CREB-binding protein (CBP) mechanism. The Journal of Biological Chemistry. 286: 15227-39. PMID 21367864 DOI: 10.1074/Jbc.M110.201996  0.283
1974 Vaughan MK, Vaughan GM, Klein DC. Arginine vasotocin: effects on development of reproductive organs. Science (New York, N.Y.). 186: 938-9. PMID 4469691 DOI: 10.1126/Science.186.4167.938  0.282
1967 Klein DC, Morii H, Talmage RV. Effect of thyrocalcitonin, administered during peritoneal lavage, on removal of bone salts and their radioisotopes. Proceedings of the Society For Experimental Biology and Medicine. Society For Experimental Biology and Medicine (New York, N.Y.). 124: 627-33. PMID 6019907 DOI: 10.3181/00379727-124-31809  0.282
1970 Klein DC, Raisz LG. Prostaglandins: stimulation of bone resorption in tissue culture. Endocrinology. 86: 1436-40. PMID 4315103 DOI: 10.1210/ENDO-86-6-1436  0.28
1986 Santer DM, Heydorn WE, Creed GJ, Klein DC, Jacobowitz DM. Subfornical organ: effects of salt loading and water deprivation on in vitro radioamino acid incorporation into individual proteins. Brain Research. 372: 107-14. PMID 3708350 DOI: 10.1016/0006-8993(86)91463-0  0.28
1996 Sugden D, Anwar N, Klein DC. Rat pineal alpha 1-adrenoceptor subtypes: studies using radioligand binding and reverse transcription-polymerase chain reaction analysis. British Journal of Pharmacology. 118: 1246-52. PMID 8818350 DOI: 10.1111/J.1476-5381.1996.Tb15530.X  0.28
2020 Chang E, Fu C, Coon SL, Alon S, Bozinoski M, Breymaier M, Bustos DM, Clokie SJ, Gothilf Y, Esnault C, Iuvone PM, Mason CE, Ochocinska MJ, Tovin A, Wang C, ... ... Klein DC, et al. Resource: A Multi-species Multi-timepoint Transcriptome Database and Webpage for the Pineal Gland and Retina. Journal of Pineal Research. e12673. PMID 32533862 DOI: 10.1111/Jpi.12673  0.278
2019 Coon SL, Fu C, Hartley SW, Holtzclaw L, Mays JC, Kelly MC, Kelley MW, Mullikin JC, Rath MF, Savastano LE, Klein DC. Single Cell Sequencing of the Pineal Gland: The Next Chapter. Frontiers in Endocrinology. 10: 590. PMID 31616371 DOI: 10.3389/Fendo.2019.00590  0.277
1973 Coyle JT, Jacobowitz D, Klein D, Axelrod J. Dopaminergic neurons in explants of substantia nigra in culture. Journal of Neurobiology. 4: 461-70. PMID 4147763 DOI: 10.1002/neu.480040507  0.277
1971 Klein DC, Raisz LG. Role of adenosine-3',5'-monophosphate in the hormonal regulation of bone resorption: studies with cultured fetal bone. Endocrinology. 89: 818-26. PMID 4327776 DOI: 10.1210/endo-89-3-818  0.276
2006 Møller M, Rath MF, Klein DC. The perivascular phagocyte of the mouse pineal gland: an antigen-presenting cell. Chronobiology International. 23: 393-401. PMID 16687312 DOI: 10.1080/07420520500521855  0.276
1992 Huang SK, Klein DC, Korf HW. Immunocytochemical demonstration of rod-opsin, S-antigen, and neuron-specific proteins in the human pineal gland. Cell and Tissue Research. 267: 493-8. PMID 1533347 DOI: 10.1007/Bf00319371  0.273
1985 Korf HW, Møller M, Gery I, Zigler JS, Klein DC. Immunocytochemical demonstration of retinal S-antigen in the pineal organ of four mammalian species. Cell and Tissue Research. 239: 81-5. PMID 3967288 DOI: 10.1007/Bf00214906  0.273
1993 Schaad NC, Parfitt A, Russell JT, Schaffner AE, Korf HW, Klein DC. Single-cell [Ca2+]i analysis and biochemical characterization of pinealocytes immobilized with novel attachment peptide preparation. Brain Research. 614: 251-6. PMID 8394187 DOI: 10.1016/0006-8993(93)91042-Q  0.273
1981 Auerbach DA, Klein DC, Kirk KL, Cantacuzene D, Creveling CR. Effects on fluorine analogs of norepinephrine on stimulation of cyclic adenosine 3',5'-monophosphate and binding to beta-adrenergic receptors in intact pinealocytes. Biochemical Pharmacology. 30: 1085-9. PMID 6266425 DOI: 10.1016/0006-2952(81)90446-9  0.272
1987 Chik CL, Ho AK, Klein DC. Ethanol inhibits dual receptor stimulation of pineal cAMP and cGMP by vasoactive intestinal peptide and phenylephrine. Biochemical and Biophysical Research Communications. 147: 145-51. PMID 2820392 DOI: 10.1016/S0006-291X(87)80099-2  0.27
2019 Alon S, Eisenberg E, Jacob-Hirsch J, Rechavi G, Vatine G, Toyama R, Coon SL, Klein DC, Gothilf Y. Corrigendum to: A new cis-acting regulatory element driving gene expression in the zebrafish pineal gland. Bioinformatics (Oxford, England). PMID 31102508 DOI: 10.1093/Bioinformatics/Btz410  0.27
1979 Namboodiri MA, Nakai C, Klein DC. Effects of selected treatments on stability and activity of pineal serotonin N-acetyltransferase. Journal of Neurochemistry. 33: 807-10. PMID 479894 DOI: 10.1111/J.1471-4159.1979.Tb05229.X  0.268
1943 BERGMAN HC, KLEIN D. RELATION OF BODY WEIGHT TO LIVER GLYCOGEN STORAGE POTENCY OF ADRENAL CORTICAL EXTRACTS Endocrinology. 33: 174-176. DOI: 10.1210/endo-33-3-174  0.267
1950 Pentz EI, Graham CE, Ryan DE, Klein D. The Ability Of Liver Preparations And Vitamin B12 To Maintain Thymus Weight In Thyroid-Fed Rats Having Greatly Hypertrophied Adrenal Glands Endocrinology. 47: 30-35. PMID 15435495 DOI: 10.1210/Endo-47-1-30  0.266
1979 Wheler GH, Klein DC. Cyclic AMP-induced release of [14C]taurine from pinealocytes. Biochemical and Biophysical Research Communications. 90: 22-7. PMID 227389 DOI: 10.1016/0006-291X(79)91584-5  0.263
1981 Namboodiri MA, Favilla JT, Klein DC. Pineal N-acetyltransferase is inactivated by disulfide-containing peptides: insulin is the most potent. Science (New York, N.Y.). 213: 571-3. PMID 7017937 DOI: 10.1126/Science.7017937  0.263
1992 Klein DC, Schaad NL, Namboordiri MA, Yu L, Weller JL. Regulation of pineal serotonin N-acetyltransferase activity. Biochemical Society Transactions. 20: 299-304. PMID 1397615 DOI: 10.1042/Bst0200299  0.262
2002 Klein DC. Serotonin N-Acetyltransferase Advances in Experimental Medicine and Biology. 460: 5-16. DOI: 10.1007/0-306-46814-X_2  0.26
2011 Zemkova H, Stojilkovic SS, Klein DC. Norepinephrine causes a biphasic change in mammalian pinealocye membrane potential: role of alpha1B-adrenoreceptors, phospholipase C, and Ca2+. Endocrinology. 152: 3842-51. PMID 21828176 DOI: 10.1210/en.2011-1180  0.256
1968 Klein DC, Talmage RV. Evidence for the secretion of thyrocalcitonin at normal and subnormal plasma calcium levels. Endocrinology. 82: 132-6. PMID 5634986 DOI: 10.1210/endo-82-1-132  0.255
1996 Iuvone PM, Alonso-Gómez AL, Bernard M, Klein DC. Circadian and light-evoked regulation of serotonin N-acetyltransferase activity and mRNA levels in chicken retina Investigative Ophthalmology and Visual Science. 37: S16.  0.254
1991 Ceña V, Halperin JI, Yeandle S, Klein DC. Norepinephrine stimulates potassium efflux from pinealocytes: evidence for involvement of biochemical "AND" gate operated by calcium and adenosine 3',5'-monophosphate. Endocrinology. 128: 559-69. PMID 1846112 DOI: 10.1210/endo-128-1-559  0.254
1993 Donohue SJ, Roseboom PH, Illnerova H, Weller JL, Klein DC. Human hydroxyindole-O-methyltransferase: presence of LINE-1 fragment in a cDNA clone and pineal mRNA. Dna and Cell Biology. 12: 715-27. PMID 8397829 DOI: 10.1089/Dna.1993.12.715  0.253
2007 Klein DC. The pineal gene expression party: who's the surprise guest? Endocrinology. 148: 1463-4. PMID 17369497 DOI: 10.1210/en.2007-0077  0.252
1999 Grève P, Alonso-Gómez A, Bernard M, Ma M, Haque R, Klein DC, Iuvone PM. Serotonin N-acetyltransferase mRNA levels in photoreceptor-enriched chicken retinal cell cultures: elevation by cyclic AMP. Journal of Neurochemistry. 73: 1894-900. PMID 10537047  0.252
1992 Klein DC, Roseboom PH, Donohue SJ, Marrs BL. Evolution of melatonin as a night signal: Contribution from a primitive photosynthetic organism. Molecular and Cellular Neurosciences. 3: 181-3. PMID 19912858 DOI: 10.1016/1044-7431(92)90036-2  0.251
1989 Korf HW, Bruce JA, Vistica B, Rollag M, Stein BM, Klein DC. Immunoreactive S-antigen in cerebrospinal fluid: a marker of pineal parenchymal tumors? Journal of Neurosurgery. 70: 682-7. PMID 2709107 DOI: 10.3171/jns.1989.70.5.0682  0.248
1970 Klein DC, Ntides A. Thin-layer chromatographic separation of pineal gland derivatives of serotonin-14C. Analytical Biochemistry. 31: 480-3. PMID 5382627 DOI: 10.1016/0003-2697(69)90290-5  0.246
2012 Clokie SJ, Lau P, Kim HH, Coon SL, Klein DC. MicroRNAs in the pineal gland: miR-483 regulates melatonin synthesis by targeting arylalkylamine N-acetyltransferase. The Journal of Biological Chemistry. 287: 25312-24. PMID 22908386 DOI: 10.1074/jbc.M112.356733  0.243
1968 Klein DC, Talmage RV. Thyrocalcitonin suppression of hydroxyproline rlease from bone. Proceedings of the Society For Experimental Biology and Medicine. Society For Experimental Biology and Medicine (New York, N.Y.). 127: 95-9. PMID 5644673 DOI: 10.3181/00379727-127-32629  0.242
1986 Korf HW, Oksche A, Ekström P, Gery I, Zigler JS, Klein DC. Pinealocyte projections into the mammalian brain revealed with S-antigen antiserum. Science (New York, N.Y.). 231: 735-7. PMID 3454660 DOI: 10.1126/Science.3454660  0.239
1984 Rollag M, Welsh M, Klein D. Response of the gerbil pineal complex to photic stimulation Journal of Steroid Biochemistry. 20: 1464. DOI: 10.1016/0022-4731(84)90614-9  0.233
1986 Korf HW, Klein DC, Zigler JS, Gery I, Schachenmayr W. S-antigen-like immunoreactivity in a human pineocytoma. Acta Neuropathologica. 69: 165-7. PMID 3515828 DOI: 10.1007/Bf00687054  0.231
2014 Yamazaki F, Kim HH, Lau P, Hwang CK, Iuvone PM, Klein D, Clokie SJ. pY RNA1-s2: a highly retina-enriched small RNA that selectively binds to Matrin 3 (Matr3). Plos One. 9: e88217. PMID 24558381 DOI: 10.1371/Journal.Pone.0088217  0.23
2002 Klein DC. Structure and function of a cAMP operated 14-3-3 binding switch: essential role in biological timing Biochemical Society Transactions. 30: A62-A62. DOI: 10.1042/bst030a062b  0.228
1979 Namboodiri MA, Klein DC. Use of charcoal adsorption for the microassay of acetyl-CoA-hydrolase. Analytical Biochemistry. 93: 244-7. PMID 37774 DOI: 10.1016/S0003-2697(79)80145-1  0.226
1993 Yi H, Donohue SJ, Klein DC, McBride OW. Localization of the hydroxyindole-O-methyltransferase gene to the pseudoautosomal region: implications for mapping of psychiatric disorders. Human Molecular Genetics. 2: 127-31. PMID 8098975 DOI: 10.1093/Hmg/2.2.127  0.225
2002 Dyda F, Ghirlando R, Ganguly S, Klein DC, Obsil T. An enzyme in a scaffold: conformational modulation of serotoninN-acetyltransferase by 14-3-3 Acta Crystallographica Section a Foundations of Crystallography. 58: c230-c230. DOI: 10.1107/S0108767302094217  0.222
1987 Ceña V, González-García C, Svoboda P, Weller JL, Klein DC. Developmental study of ouabain inhibition of adrenergic induction of rat pineal serotonin N-acetyltransferase (EC 2.3.1.87). The Journal of Biological Chemistry. 262: 14467-71. PMID 2822693  0.218
2022 Klein DC, Coon SL. The Pineal Transcriptome Webpage. Methods in Molecular Biology (Clifton, N.J.). 2550: 133-137. PMID 36180686 DOI: 10.1007/978-1-0716-2593-4_17  0.213
1993 Slim R, Le Paslier D, Compain S, Levilliers J, Ougen P, Billault A, Donohue SJ, Klein DC, Mintz L, Bernheim A. Construction of a yeast artificial chromosome contig spanning the pseudoautosomal region and isolation of 25 new sequence-tagged sites. Genomics. 16: 691-7. PMID 8100802 DOI: 10.1006/Geno.1993.1249  0.212
1983 Kapatos G, Kaufman S, Weller JL, Klein DC. The development of tetrahydrobiopterin and guanosine-5'-triphosphate cyclohydrolase: differential patterns in rat brain and pineal gland. Brain Research. 258: 351-5. PMID 6824919 DOI: 10.1016/0006-8993(83)91165-4  0.209
1998 Be Gay VR, Falco N J, Cahill GM, Klein DC, Coon SL. Transcripts Encoding Two Melatonin Synthesis Enzymes in the Teleost Pineal Organ: Circadian Regulation in Pike and Zebrafish, But Not in Trout. Endocrinology. 139: 905-912. PMID 28200493 DOI: 10.1210/endo.139.3.5790  0.208
1944 Hier SW, Graham CE, Klein D. Inhibitory Effect of Certain Amino Acids on Growth of Young Male Rats Experimental Biology and Medicine. 56: 187-190. DOI: 10.3181/00379727-56-14645  0.207
1985 Klein DC. Photoneural regulation of the mammalian pineal gland. Ciba Foundation Symposium. 117: 38-56. PMID 3015512  0.202
2004 Cherry JD, Chang SJ, Klein D, Lee M, Barenkamp S, Bernstein D, Edelman R, Decker MD, Greenberg DP, Keitel W, Treanor J, Ward JI. Prevalence of antibody to Bordetella pertussis antigens in serum specimens obtained from 1793 adolescents and adults. Clinical Infectious Diseases : An Official Publication of the Infectious Diseases Society of America. 39: 1715-8. PMID 15578376 DOI: 10.1086/425003  0.202
1995 Roseboom PH, Klein DC. Norepinephrine stimulation of pineal cyclic AMP response element-binding protein phosphorylation: primary role of a beta-adrenergic receptor/cyclic AMP mechanism. Molecular Pharmacology. 47: 439-49. PMID 7700241  0.2
1999 Gothilf Y, Coon SL, Toyama R, Chitnis A, Namboodiri MA, Klein DC. Zebrafish Serotonin N-Acetyltransferase-2: Marker for Development of Pineal Photoreceptors and Circadian Clock Function1. Endocrinology. 140: 4895-4903. PMID 28200459 DOI: 10.1210/endo.140.10.6975  0.199
1996 Klein DC, Roseboom PH, Coon SL. New light is shining on the melatonin rhythm enzyme the first postcloning view Trends in Endocrinology and Metabolism. 7: 106-112. DOI: 10.1016/1043-2760(96)00033-1  0.195
2019 Pearlman AT, Schvey NA, Neyland MKH, Solomon S, Hennigan K, Schindler R, Leu W, Gillmore D, Shank LM, Lavender JM, Burke NL, Wilfley DE, Sbrocco T, Stephens M, Jorgensen S, ... Klein D, et al. Associations between Family Weight-Based Teasing, Eating Pathology, and Psychosocial Functioning among Adolescent Military Dependents. International Journal of Environmental Research and Public Health. 17. PMID 31861426 DOI: 10.3390/Ijerph17010024  0.193
2019 Quattlebaum M, Burke NL, Higgins Neyland MK, Leu W, Schvey NA, Pine A, Morettini A, LeMay-Russell S, Wilfley DE, Stephens M, Sbrocco T, Yanovski JA, Jorgensen S, Olsen C, Klein D, et al. Sex differences in eating related behaviors and psychopathology among adolescent military dependents at risk for adult obesity and eating disorders. Eating Behaviors. 33: 73-77. PMID 31005683 DOI: 10.1016/J.Eatbeh.2019.04.001  0.192
1983 Klein DC, Wheler GH, Weller JL. Taurine in the pineal gland. Progress in Clinical and Biological Research. 125: 169-81. PMID 6308680  0.188
1973 Klein DC, Yuwiler A, Bensinger R. Beta-adrenergic regulation of serotonin in the cultured rat pineal gland Life Sciences. 13: lxxxvi-lxxxvii. DOI: 10.1016/0024-3205(73)90310-X  0.187
1997 Coon SL, McCune SK, Sugden D, Klein DC. Regulation of pineal alpha1B-adrenergic receptor mRNA: day/night rhythm and beta-adrenergic receptor/cyclic AMP control. Molecular Pharmacology. 51: 551-7. PMID 9106618 DOI: 10.1124/MOL.51.4.551  0.185
1987 Sugden D, Klein DC. A cholera toxin substrate regulates cyclic GMP content of rat pinealocytes. The Journal of Biological Chemistry. 262: 7447-50. PMID 3034896  0.184
1987 Klein DC. Quantitative analysis of catecholamines and related compounds Analytical Biochemistry. 162: 575. DOI: 10.1016/0003-2697(87)90437-4  0.184
1987 Sugden D, Ceña V, Klein DC. Hydroxyindole O-methyltransferase. Methods in Enzymology. 142: 590-6. PMID 3298987 DOI: 10.1016/S0076-6879(87)42070-3  0.182
1984 Matthew E, Parfitt AG, Sugden D, Engelhardt DL, Zimmerman EA, Klein DC. Benzodiazepines: rat pinealocyte binding sites and augmentation of norepinephrine-stimulated N-acetyltransferase activity. The Journal of Pharmacology and Experimental Therapeutics. 228: 434-8. PMID 6319679  0.182
2002 Humphries A, Klein D, Baler R, Carter DA. Oestrogen receptors, receptor variants and oestrogen actions in the hypothalamic-pituitary axis Journal of Neuroendocrinology. 14: 85-94. PMID 11849367 DOI: 10.1046/j.0007-1331.2001.00744.x  0.179
1989 Newman AH, McCabe RT, Schoenheimer JA, Skolnick P, Rice KC, Reig JA, Klein DC. [3H]AHN 086 acylates peripheral benzodiazepine receptors in the rat pineal gland. Nida Research Monograph. 95: 285-6. PMID 2561833  0.178
2018 Liu Y, Tyler E, Lustick M, Klein D, Walter K. HOUT-29. HEALTHCARE COSTS FOR HIGH-GRADE GLIOMAS: A POPULATION-BASED STUDY Neuro-Oncology. 20: vi119-vi119. DOI: 10.1093/neuonc/noy148.497  0.176
2022 Klein DC. Two-Dimensional Thin Layer Chromatography of Melatonin and Related Compounds. Methods in Molecular Biology (Clifton, N.J.). 2550: 3-6. PMID 36180670 DOI: 10.1007/978-1-0716-2593-4_1  0.173
2019 Liu Y, Tyler E, Lustick M, Klein D, Walter KA. Healthcare Costs for High-grade Glioma. Anticancer Research. 39: 1375-1381. PMID 30842171 DOI: 10.21873/anticanres.13251  0.172
1986 Sugden AL, Sugden D, Klein DC. Essential role of calcium influx in the adrenergic regulation of cAMP and cGMP in rat pinealocytes. The Journal of Biological Chemistry. 261: 11608-12. PMID 3017936  0.166
1975 Parfitt A, Weller JL, Klein DC, Sakai KK, Marks BH. Blockade by ouabain or elevated potassium ion concentration of the adrenergic and adenosine cyclic 3',5'-monophosphate-induced stimulation of pineal serotonin N-acetyltransferase activity. Molecular Pharmacology. 11: 241-55. PMID 167274  0.165
1987 Namboodiri MA, Dubbels R, Klein DC. Arylalkylamine N-acetyltransferase from mammalian pineal gland. Methods in Enzymology. 142: 583-90. PMID 3298986 DOI: 10.1016/S0076-6879(87)42069-7  0.16
1990 Shyjan AW, Ceña V, Klein DC, Levenson R. Differential expression and enzymatic properties of the Na+,K(+)-ATPase alpha 3 isoenzyme in rat pineal glands. Proceedings of the National Academy of Sciences of the United States of America. 87: 1178-82. PMID 2153972 DOI: 10.1073/Pnas.87.3.1178  0.16
1989 Ho AK, Chik CL, Weller JL, Cragoe EJ, Klein DC. Evidence of alpha 1-adrenergic----protein kinase C----Na+/H+ antiporter-dependent increase in pinealocyte intracellular pH. Role in the adrenergic stimulation of cGMP accumulation. The Journal of Biological Chemistry. 264: 12983-8. PMID 2568991  0.156
1978 Klein DC, Buda MJ, Kapoor CL, Krishna G. Pineal serotonin N-acetyltransferase activity: abrupt decrease in adenosine 3',5'-monophosphate may be signal for "turnoff". Science (New York, N.Y.). 199: 309-11. PMID 202027  0.156
1985 Sugden D, Namboodiri MA, Klein DC, Pierce JE, Grady R, Mefford IN. Ovine pineal alpha 1-adrenoceptors: characterization and evidence for a functional role in the regulation of serum melatonin. Endocrinology. 116: 1960-7. PMID 2985366 DOI: 10.1210/endo-116-5-1960  0.154
1976 Binkley S, Klein DC, Weller JL. Pineal serotonin N-acetyltransferase activity: protection of stimulated activity by acetyl-CoA and related compounds. Journal of Neurochemistry. 26: 51-5. PMID 1255183  0.153
1988 Ho AK, Thomas TP, Chik CL, Anderson WB, Klein DC. Protein kinase C: subcellular redistribution by increased Ca2+ influx. Evidence that Ca2+-dependent subcellular redistribution of protein kinase C is involved in potentiation of beta-adrenergic stimulation of pineal cAMP and cGMP by K+ and A23187. The Journal of Biological Chemistry. 263: 9292-7. PMID 2897966  0.153
2012 Curtis PD, Quardokus EM, Lawler ML, Guo X, Klein D, Chen JC, Arnold RJ, Brun YV. The scaffolding and signalling functions of a localization factor impact polar development. Molecular Microbiology. 84: 712-35. PMID 22512778 DOI: 10.1111/J.1365-2958.2012.08055.X  0.151
1987 Sugden LA, Sugden D, Klein DC. Alpha 1-adrenoceptor activation elevates cytosolic calcium in rat pinealocytes by increasing net influx. The Journal of Biological Chemistry. 262: 741-5. PMID 3027065  0.151
2001 Falco N J, Galarneau KM, Weller JL, Ron B, Chen G, Coon SL, Klein DC. Regulation of Arylalkylamine N-Acetyltransferase-2 (AANAT2, EC 2.3.1.87) in the Fish Pineal Organ: Evidence for a Role of Proteasomal Proteolysis. Endocrinology. 142: 1804-1813. PMID 28201192 DOI: 10.1210/endo.142.5.8129  0.149
2022 Madhani SI, Klein DC, Muñoz EM, Savastano LE. Surgical Techniques and Nuances for Superior Cervical Ganglionectomy and Decentralization in Rats. Methods in Molecular Biology (Clifton, N.J.). 2550: 53-62. PMID 36180677 DOI: 10.1007/978-1-0716-2593-4_8  0.147
1980 Namboodiri MA, Weller JL, Klein DC. Evidence of inactivation of pineal indoleamine N-acetyltransferase by protein thiol:disulfide exchange. The Journal of Biological Chemistry. 255: 6032-5. PMID 7391004  0.146
2019 Stermer AR, Wilson SK, Klein D, Hall SJ, Boekelheide K. Trichloroethylene exposure alters dimethylated histone three lysine four in protein kinase A signaling pathway chromatin of rat sperm. Biology of Reproduction. PMID 31426087 DOI: 10.1093/Biolre/Ioz155  0.143
1978 Klein DC. The pineal gland: a model of neuroendocrine regulation. Research Publications - Association For Research in Nervous and Mental Disease. 56: 303-27. PMID 23573  0.142
2018 Wilson S, Dere E, Klein D, Schorl C, Hall S, Boekelheide K. Localization of dimethylated histone three lysine four in the Rattus norvegicus sperm genome. Biology of Reproduction. PMID 29506216 DOI: 10.1093/Biolre/Ioy051  0.142
1995 Schaad NC, Vanecek J, Rodriguez IR, Klein DC, Holtzclaw L, Russell JT. Vasoactive intestinal peptide elevates pinealocyte intracellular calcium concentrations by enhancing influx: evidence for involvement of a cyclic GMP-dependent mechanism. Molecular Pharmacology. 47: 923-33. PMID 7538196  0.141
1987 González-García C, Ceña V, Klein DC. Characterization of the alpha +-like Na+,K+-ATPase which mediates ouabain inhibition of adrenergic induction of N-acetyltransferase (EC 2.3.1.87) activity: studies with isolated pinealocytes. Molecular Pharmacology. 32: 792-7. PMID 2826993  0.14
1987 Ho AK, Klein DC. Activation of alpha 1-adrenoceptors, protein kinase C, or treatment with intracellular free Ca2+ elevating agents increases pineal phospholipase A2 activity. Evidence that protein kinase C may participate in Ca2+-dependent alpha 1-adrenergic stimulation of pineal phospholipase A2 activity. The Journal of Biological Chemistry. 262: 11764-70. PMID 2887563  0.138
2018 McGilvray WD, Klein D, Wooten H, Dawson JA, Hewitt D, Rakhshandeh AR, de Lange CFM, Rakhshandeh A. Immune system stimulation induced by Escherichia coli lipopolysaccharide alters plasma free amino acid flux and dietary nitrogen utilization in growing pigs. Journal of Animal Science. PMID 30329054 DOI: 10.1093/jas/sky401  0.138
1987 Ho AK, Chik CL, Klein DC. Protein kinase C is involved in adrenergic stimulation of pineal cGMP accumulation. The Journal of Biological Chemistry. 262: 10059-64. PMID 3038864  0.137
1996 Rodriguez IR, Coon SL, Mazuruk K, Bernard M, Roseboom PH, Klein DC. Structural organization, localization and expression of the human serotonin N-acetyltransferase gene Investigative Ophthalmology and Visual Science. 37: S948.  0.131
1990 Reig JA, Yu L, Klein DC. Pineal transduction. Adrenergic----cyclic AMP-dependent phosphorylation of cytoplasmic 33-kDa protein (MEKA) which binds beta gamma-complex of transducin. The Journal of Biological Chemistry. 265: 5816-24. PMID 2156830  0.131
1984 Voisin P, Namboodiri MA, Klein DC. Arylamine N-acetyltransferase and arylalkylamine N-acetyltransferase in the mammalian pineal gland. The Journal of Biological Chemistry. 259: 10913-8. PMID 6469990  0.131
2000 Dyda F, Namboodiri MAA, Klein DC, Hickman AB. The Structure of Serotonin N-Acetyltransferase: Illustrating Catalysis by the GCN5-Related N-Acetyltransferase (GNAT) Enzyme Superfamily Acta Crystallographica Section a Foundations of Crystallography. 56: s257-s257. DOI: 10.1107/S0108767300025514  0.123
2003 Stamouli A, Kafi S, Klein DC, Oosterkamp TH, Frenken JW, Cogdell RJ, Aartsma TJ. The ring structure and organization of light harvesting 2 complexes in a reconstituted lipid bilayer, resolved by atomic force microscopy. Biophysical Journal. 84: 2483-91. PMID 12668456 DOI: 10.1016/S0006-3495(03)75053-X  0.122
2023 Klein DC, Lardo SM, Hainer SJ. The ncBAF complex regulates transcription in AML through H3K27ac sensing by BRD9. Cancer Research Communications. PMID 38126767 DOI: 10.1158/2767-9764.CRC-23-0382  0.12
2019 McGilvray WD, Klein D, Wooten H, Dawson JA, Hewitt D, Rakhshandeh AR, De Lange CFM, Rakhshandeh A. Immune system stimulation induced by porcine reproductive and respiratory syndrome virus alters plasma free amino acid flux and dietary nitrogen utilization in starter pigs1. Journal of Animal Science. PMID 31062849 DOI: 10.1093/jas/skz120  0.12
2022 Coon SL, Klein DC. RNA Sequencing of Single Pineal Cells. Methods in Molecular Biology (Clifton, N.J.). 2550: 105-112. PMID 36180683 DOI: 10.1007/978-1-0716-2593-4_14  0.118
2019 Klein DC, Hainer SJ. Genomic methods in profiling DNA accessibility and factor localization. Chromosome Research : An International Journal On the Molecular, Supramolecular and Evolutionary Aspects of Chromosome Biology. PMID 31776829 DOI: 10.1007/s10577-019-09619-9  0.118
1987 Sugden D, Klein DC. Inactivation of rat pineal hydroxyindole-O-methyltransferase by disulfide-containing compounds. The Journal of Biological Chemistry. 262: 6489-93. PMID 3571267  0.115
2012 Fischedick G, Klein DC, Wu G, Esch D, Höing S, Han DW, Reinhardt P, Hergarten K, Tapia N, Schöler HR, Sterneckert JL. Zfp296 is a novel, pluripotent-specific reprogramming factor. Plos One. 7: e34645. PMID 22485183 DOI: 10.1371/journal.pone.0034645  0.11
2022 Coon SL, Klein DC. Preparation of Single Pineal Cells. Methods in Molecular Biology (Clifton, N.J.). 2550: 101-104. PMID 36180682 DOI: 10.1007/978-1-0716-2593-4_13  0.108
1986 van Veen T, Elofsson R, Hartwig HG, Gery I, Mochizuki M, Ceña V, Klein DC. Retinal S-antigen: immunocytochemical and immunochemical studies on distribution in animal photoreceptors and pineal organs. Experimental Biology. 45: 15-25. PMID 3956700  0.102
2023 Klein DC, Lardo SM, McCannell KN, Hainer SJ. FACT regulates pluripotency through proximal and distal regulation of gene expression in murine embryonic stem cells. Bmc Biology. 21: 167. PMID 37542287 DOI: 10.1186/s12915-023-01669-0  0.097
1999 Klein DC. Serotonin N-acetyltransferase. A personal historical perspective. Advances in Experimental Medicine and Biology. 460: 5-16. PMID 10810495  0.097
2002 van Hemert MJ, Lamers GE, Klein DC, Oosterkamp TH, Steensma HY, van Heusden GP. The Saccharomyces cerevisiae Fin1 protein forms cell cycle-specific filaments between spindle pole bodies. Proceedings of the National Academy of Sciences of the United States of America. 99: 5390-3. PMID 11929974 DOI: 10.1073/pnas.072556099  0.095
2019 Stermer AR, Klein D, Wilson SK, Dalaijamts C, Bai CY, Hall SJ, Madnick S, Bianchi E, Chiu WA, Boekelheide K. Differential toxicity of water versus gavage exposure to trichloroethylene in rats. Environmental Toxicology and Pharmacology. 68: 1-3. PMID 30836291 DOI: 10.1016/J.Etap.2019.02.003  0.094
2020 Klein DC, Hainer SJ. Chromatin regulation and dynamics in stem cells. Current Topics in Developmental Biology. 138: 1-71. PMID 32220294 DOI: 10.1016/bs.ctdb.2019.11.002  0.087
2013 Curtis PD, Klein D, Brun YV. Effect of a ctrA promoter mutation, causing a reduction in CtrA abundance, on the cell cycle and development of Caulobacter crescentus. Bmc Microbiology. 13: 166. PMID 23865946 DOI: 10.1186/1471-2180-13-166  0.086
1977 Klein DC, Weller JL, Kirk KL, Hartley RW. Incorporation of 2-fluoro-L-histidine into cellular protein. Molecular Pharmacology. 13: 1105-10. PMID 593264  0.086
2006 Lawler ML, Larson DE, Hinz AJ, Klein D, Brun YV. Dissection of functional domains of the polar localization factor PodJ in Caulobacter crescentus. Molecular Microbiology. 59: 301-16. PMID 16359336 DOI: 10.1111/J.1365-2958.2005.04935.X  0.083
1976 Klein DC, Kirk KL, Weller JL, Oka T, Parfitt A, Owens IS. 2-Fluoro-L-histidine, an inhibitor of enzyme induction. Molecular Pharmacology. 12: 720-30. PMID 11408  0.08
2011 Esteves TC, Balbach ST, Pfeiffer MJ, Araúzo-Bravo MJ, Klein DC, Sinn M, Boiani M. Somatic cell nuclear reprogramming of mouse oocytes endures beyond reproductive decline. Aging Cell. 10: 80-95. PMID 20969722 DOI: 10.1111/j.1474-9726.2010.00644.x  0.078
2022 Kothare H, Schneider S, Mizuiri D, Hinkley L, Bhutada A, Ranasinghe K, Honma S, Garrett C, Klein D, Naunheim M, Yung K, Cheung S, Rosen C, Courey M, Nagarajan S, et al. Temporal specificity of abnormal neural oscillations during phonatory events in laryngeal dystonia. Brain Communications. 4: fcac031. PMID 35356032 DOI: 10.1093/braincomms/fcac031  0.078
2015 Klein DC, Skjesol A, Kers-Rebel ED, Sherstova T, Sporsheim B, Egeberg KW, Stokke BT, Espevik T, Husebye H. CD14, TLR4 and TRAM Show Different Trafficking Dynamics During LPS Stimulation. Traffic (Copenhagen, Denmark). 16: 677-90. PMID 25707286 DOI: 10.1111/tra.12274  0.078
2022 Thompson K, Klein D, Sreekumar S, Kenny L, Campbell K, Alaia M, Strauss EJ, Jazrawi L, Gonzalez-Lomas G. Testosterone Levels Before and After Anterior Cruciate Ligament Reconstruction A Prospective Observational Study. Bulletin of the Hospital For Joint Disease (2013). 80: 265-269. PMID 36030446  0.077
2015 Wald R, Adhikari NK, Smith OM, Weir MA, Pope K, Cohen A, Thorpe K, McIntyre L, Lamontagne F, Soth M, Herridge M, Lapinsky S, Clark E, Garg AX, Hiremath S, ... Klein D, et al. Comparison of standard and accelerated initiation of renal replacement therapy in acute kidney injury. Kidney International. PMID 26154928 DOI: 10.1038/ki.2015.184  0.077
2007 Latz E, Verma A, Visintin A, Gong M, Sirois CM, Klein DC, Monks BG, McKnight CJ, Lamphier MS, Duprex WP, Espevik T, Golenbock DT. Ligand-induced conformational changes allosterically activate Toll-like receptor 9. Nature Immunology. 8: 772-9. PMID 17572678 DOI: 10.1038/ni1479  0.075
2020 Klein D, Bloom D, Campbell K, Gonzalez-Lomas G, Alaia M, Strauss E, Jazrawi L, Thompson K. Alpha-2-Macroglobulin Not Significantly Better Than Regular PRP For Knee Arthritis Symptoms Orthopaedic Journal of Sports Medicine. 8: 2325967120S0045. DOI: 10.1177/2325967120s00454  0.075
1982 Namboodiri MA, Favilla JT, Klein DC. Activation of pineal acetyl coenzyme A hydrolase by disulfide peptides. The Journal of Biological Chemistry. 257: 10030-2. PMID 6125507  0.074
2003 Klein DC, Stroh CM, Jensenius H, van Es M, Kamruzzahan AS, Stamouli A, Gruber HJ, Oosterkamp TH, Hinterdorfer P. Covalent immobilization of single proteins on mica for molecular recognition force microscopy. Chemphyschem : a European Journal of Chemical Physics and Physical Chemistry. 4: 1367-71. PMID 14714391 DOI: 10.1002/cphc.200300844  0.073
2020 Shellenberger NW, Collinsworth KK, Subbiah S, Klein D, Neary JM. Hypoxia induces an increase in intestinal permeability and pulmonary arterial pressures in neonatal Holstein calves despite feeding the flavonoid rutin. Journal of Dairy Science. PMID 31954560 DOI: 10.3168/Jds.2019-17289  0.073
2023 Klein DC, Troy K, Tripplehorn SA, Hainer SJ. The esBAF and ISWI nucleosome remodeling complexes influence occupancy of overlapping dinucleosomes and fragile nucleosomes in murine embryonic stem cells. Bmc Genomics. 24: 201. PMID 37055726 DOI: 10.1186/s12864-023-09287-4  0.07
2020 Strauss EJ, Kingery MT, Klein D, Manjunath AK. The Evaluation and Management of Suprascapular Neuropathy. The Journal of the American Academy of Orthopaedic Surgeons. 28: 617-627. PMID 32732653 DOI: 10.5435/JAAOS-D-19-00526  0.068
2013 Barzman DH, Mossman D, Appel K, Blom TJ, Strawn JR, Ekhator NN, Patel B, DelBello MP, Sorter M, Klein D, Geracioti TD. The association between salivary hormone levels and children's inpatient aggression: a pilot study. The Psychiatric Quarterly. 84: 475-84. PMID 23508357 DOI: 10.1007/s11126-013-9260-8  0.067
2017 Oates RP, Klein D, Longley G, Hamlett P. Pharmaceutical And Endocrine Disruptor Compounds in Surface and Wastewater in San Marcos, TX. Water Environment Research : a Research Publication of the Water Environment Federation. PMID 28569237 DOI: 10.2175/106143017X14902968254584  0.061
2020 Whitney D, Klein D, Rodriguez T, Kenny L, Strauss E, Kingery M. Synovial Fluid Biomarkers in the Osteoarthritic Knee: Differences in Concentration with Progression of Radiographic Severity Orthopaedic Journal of Sports Medicine. 8: 2325967120S0044. DOI: 10.1177/2325967120s00446  0.061
2015 Charbonney E, Tsang JY, Li Y, Klein D, Duque P, Romaschin A, Marshall JC. Endotoxemia Following Multiple Trauma: Risk Factors and Prognostic Implications. Critical Care Medicine. PMID 26509322 DOI: 10.1097/Ccm.0000000000001404  0.058
2016 Sharifan H, Klein D, Morse AN. UV filters interaction in the chlorinated swimming pool, a new challenge for urbanization, a need for community scale investigations. Environmental Research. 148: 273-276. PMID 27088731 DOI: 10.1016/j.envres.2016.04.002  0.057
2010 Sterneckert J, Stehling M, Bernemann C, Araúzo-Bravo MJ, Greber B, Gentile L, Ortmeier C, Sinn M, Wu G, Ruau D, Zenke M, Brintrup R, Klein DC, Ko K, Schöler HR. Neural induction intermediates exhibit distinct roles of Fgf signaling. Stem Cells (Dayton, Ohio). 28: 1772-81. PMID 20715182 DOI: 10.1002/stem.498  0.056
2012 Klein DC, Øvrebø KM, Latz E, Espevik T, Stokke BT. Direct measurement of the interaction force between immunostimulatory CpG-DNA and TLR9 fusion protein. Journal of Molecular Recognition : Jmr. 25: 74-81. PMID 22290768 DOI: 10.1002/jmr.2156  0.055
2021 Rigter T, Klein D, Weinreich SS, Cornel MC. Moving somatic gene editing to the clinic: routes to market access and reimbursement in Europe. European Journal of Human Genetics : Ejhg. 29: 1477-1484. PMID 33850300 DOI: 10.1038/s41431-021-00877-y  0.055
2019 Collas P, Klein D, Schwebler HP. Convergence of Hamiltonian systems to billiards. Chaos (Woodbury, N.Y.). 8: 466-474. PMID 12779750 DOI: 10.1063/1.166328  0.054
2003 Eng K, Klein D, Bäbler A, Bernardet U, Blanchard M, Costa M, Delbrück T, Douglas RJ, Hepp K, Manzolli J, Mintz M, Roth F, Rutishauser U, Wassermann K, Whatley AM, et al. Design for a brain revisited: the neuromorphic design and functionality of the interactive space 'Ada'. Reviews in the Neurosciences. 14: 145-80. PMID 12929924 DOI: 10.1515/Revneuro.2003.14.1-2.145  0.051
1979 Hattingh J, Klein D. Binding of tryptophan and iron by reptilion plasnna proteins South African Journal of Zoology. 14: 109-110. DOI: 10.1080/02541858.1979.11447658  0.05
2021 Gonzalez-Pena V, Natarajan S, Xia Y, Klein D, Carter R, Pang Y, Shaner B, Annu K, Putnam D, Chen W, Connelly J, Pruett-Miller S, Chen X, Easton J, Gawad C. Accurate genomic variant detection in single cells with primary template-directed amplification. Proceedings of the National Academy of Sciences of the United States of America. 118. PMID 34099548 DOI: 10.1073/pnas.2024176118  0.049
2020 Sen D, Brunton J, Melchior L, Klein D, Levy GH, Wainscoat B, Chuang L. Peritoneal tuberculosis: A case report on a rare cause of tumor marker elevation. Case Reports in Women's Health. 28: e00264. PMID 33145180 DOI: 10.1016/j.crwh.2020.e00264  0.049
1988 Reig JA, Klein DC. Submicrogram quantities of unstained proteins are visualized on polyvinylidene difluoride membranes by transillumination. Applied and Theoretical Electrophoresis : the Official Journal of the International Electrophoresis Society. 1: 59-60. PMID 2484988  0.047
2022 Barsan V, Xia Y, Klein D, Gonzalez-Pena V, Youssef S, Inaba Y, Mahmud O, Natarajan S, Agarwal V, Pang Y, Autry R, Pui CH, Inaba H, Evans W, Gawad C. Simultaneous monitoring of disease and microbe dynamics through plasma DNA sequencing in pediatric patients with acute lymphoblastic leukemia. Science Advances. 8: eabj1360. PMID 35442732 DOI: 10.1126/sciadv.abj1360  0.047
2022 Kashef Al-Ghetaa R, Daniel I, Shaw J, Klein D, Brown A. The determinants of effective inter-organization information sharing in the health capital planning process. Healthcare Management Forum. 8404704221087408. PMID 35507410 DOI: 10.1177/08404704221087408  0.045
2012 Gordon MB, Sectish TC, Elliott MN, Klein D, Landrigan CP, Bogart LM, Amrock S, Burke A, Chiang VW, Schuster MA. Pediatric residents' perspectives on reducing work hours and lengthening residency: a national survey. Pediatrics. 130: 99-107. PMID 22665414 DOI: 10.1542/Peds.2011-3498  0.044
1979 Kvetnansky R, Kopin IJ, Klein DC. Stress increases pineal epinephrine. Communications in Psychopharmacology. 3: 69-72. PMID 572754  0.043
2017 Hayden M, Bhawal R, Escobedo J, Harmon C, O'Hara T, Klein D, San-Francisco S, Zabet-Moghaddam M, Godard-Codding CAJ. Nano-LC-MS/MS analysis of steroids from gray whale blubber. Rapid Communications in Mass Spectrometry : Rcm. PMID 28423207 DOI: 10.1002/Rcm.7884  0.043
2003 Fritz J, Shamma S, Elhilali M, Klein D. Rapid task-related plasticity of spectrotemporal receptive fields in primary auditory cortex. Nature Neuroscience. 6: 1216-23. PMID 14583754 DOI: 10.1038/nn1141  0.042
1971 Berg GR, Klein DC. Non-Cartesian pineal function. The New England Journal of Medicine. 284: 332. PMID 5539461 DOI: 10.1056/nejm197102112840614  0.041
2013 Misund K, Baranowska KA, Holien T, Rampa C, Klein DC, Børset M, Waage A, Sundan A. A method for measurement of drug sensitivity of myeloma cells co-cultured with bone marrow stromal cells. Journal of Biomolecular Screening. 18: 637-46. PMID 23446700 DOI: 10.1177/1087057113478168  0.041
2015 Lim L, Yan F, Bach S, Pihakari K, Klein D. Fourier Transform Mass Spectrometry: The Transformation of Modern Environmental Analyses. International Journal of Molecular Sciences. 17. PMID 26784175 DOI: 10.3390/ijms17010104  0.04
2004 FRANCESCHETTI A, BROCHER JE, KLEIN D. [Unilateral mandibulo-facial dysostosis with multiple skeletal deformities (paramastoïde process, vertebral synostosis, sacralization, etc.) and clonic torticollis]. Ophthalmologica. Journal International D'Ophtalmologie. International Journal of Ophthalmology. Zeitschrift Fur Augenheilkunde. 118: 796-814. PMID 15401034 DOI: 10.1159/000300779  0.04
2012 Tzischinsky O, Cohen A, Doveh E, Epstein R, Ribak J, Klein D, Pillar G, Lavie P. Screening for sleep disordered breathing among applicants for a professional driver's license. Journal of Occupational and Environmental Medicine / American College of Occupational and Environmental Medicine. 54: 1275-80. PMID 22995810 DOI: 10.1097/Jom.0B013E31825B1Bb1  0.039
2018 Henry RR, Strange P, Zhou R, Pettus J, Shi L, Zhuplatov SB, Mansfield T, Klein D, Katz A. Effects of Dapagliflozin on 24-Hour Glycemic Control in Patients with Type 2 Diabetes: A Randomized Controlled Trial. Diabetes Technology & Therapeutics. PMID 30222367 DOI: 10.1089/dia.2018.0052  0.039
1992 Donohue SJ, Roseboom PH, Klein DC. Bovine hydroxyindole-O-methyltransferase. Significant sequence revision. The Journal of Biological Chemistry. 267: 5184-5. PMID 1544900  0.038
2019 Klein D, Goldman R. Treatment of late Patella Baja after an otherwise routine total knee arthroplasty. The Knee. PMID 30611641 DOI: 10.1016/j.knee.2018.10.016  0.038
2015 Schvey NA, Sbrocco T, Stephens M, Bryant EJ, Ress R, Spieker EA, Conforte A, Bakalar JL, Pickworth CK, Barmine M, Klein D, Brady SM, Yanovski JA, Tanofsky-Kraff M. Comparison of overweight and obese military-dependent and civilian adolescent girls with loss-of-control eating. The International Journal of Eating Disorders. PMID 25955761 DOI: 10.1002/Eat.22424  0.037
2005 Klein D, Schmeling J, Blanck P. Emerging technologies and corporate culture at Microsoft: a methodological note. Behavioral Sciences & the Law. 23: 65-96. PMID 15706603 DOI: 10.1002/bsl.627  0.036
2023 Griepp DW, Miller A, Sorek S, Naeem K, Moawad S, Klein D, DeMattia JA, Rahme R. Emergency decompressive surgery in patients with transtentorial brain herniation and pupillary abnormalities: the importance of improved pupillary response after osmotherapy and surgery. Journal of Neurosurgery. 1-8. PMID 37548576 DOI: 10.3171/2023.5.JNS23163  0.036
2016 Vajda EG, Logan D, Lasseter K, Armas D, Plotkin DJ, Pipkin JD, Li YX, Zhou R, Klein D, Wei X, Dilzer S, Zhi L, Marschke KB. Pharmacokinetics and pharmacodynamics of single and multiple doses of the glucagon receptor antagonist LGD-6972 in healthy subjects and subjects with type 2 diabetes mellitus. Diabetes, Obesity & Metabolism. PMID 27501510 DOI: 10.1111/dom.12752  0.035
1954 Franceschetti A, Wildi E, Klein D. EXAMEN ANATOMO-CLINIQUE D’UN CAS D’lDIOTIE AMAUROTIQUE INFANTILE (TAY-SACHS) Human Heredity. 5: 343-357. DOI: 10.1159/000150782  0.035
2009 Jensenius H, Klein DC, van Hecke M, Oosterkamp TH, Schmidt T, Jensenius JC. Mannan-binding lectin: structure, oligomerization, and flexibility studied by atomic force microscopy. Journal of Molecular Biology. 391: 246-59. PMID 19501100 DOI: 10.1016/j.jmb.2009.05.083  0.035
2006 Mighell MA, Harkins D, Klein D, Schneider S, Frankle M. Technique for internal fixation of capitellum and lateral trochlea fractures. Journal of Orthopaedic Trauma. 20: 699-704. PMID 17106381 DOI: 10.1097/01.bot.0000246411.33047.80  0.034
2008 Elliott MN, Finch BK, Klein D, Ma S, Do DP, Beckett MK, Orr N, Lurie N. Sample designs for measuring the health of small racial/ethnic subgroups. Statistics in Medicine. 27: 4016-29. PMID 18351713 DOI: 10.1002/Sim.3244  0.034
2022 Khurana S, Pertschuk M, Newton K, Klein D, Du W. Transition to Inpatient Telepsychiatry Services and Impact on Quality of Care. Journal of Psychiatric Practice. 28: 492-496. PMID 36355589 DOI: 10.1097/PRA.0000000000000675  0.033
2023 Klein DC, Troy K, Tripplehorn SA, Hainer SJ. Correction: The esBAF and ISWI nucleosome remodeling complexes influence occupancy of overlapping dinucleosomes and fragile nucleosomes in murine embryonic stem cells. Bmc Genomics. 24: 699. PMID 37990151 DOI: 10.1186/s12864-023-09806-3  0.033
2020 Klein D, Campbell K, Jazrawi L, Bloom D, Baron S. Preoperative opioid education has no effect on opioid use in patients undergoing arthroscopic rotator cuff repair: a prospective, randomized clinical trial Orthopaedic Journal of Sports Medicine. 8: 2325967120S0041. DOI: 10.1177/2325967120s00414  0.032
2020 Klein D, Kupka J. Completions and algebraic formulas for the coefficients of Ramanujan's mock theta functions. The Ramanujan Journal. 56: 1029-1060. PMID 34840518 DOI: 10.1007/s11139-020-00324-4  0.031
2012 Klein D, Briere TM, Kudchadker R, Archambault L, Beaulieu L, Lee A, Beddar S. In-phantom dose verification of prostate IMRT and VMAT deliveries using plastic scintillation detectors. Radiation Measurements. 47: 921-929. PMID 23180976 DOI: 10.1016/j.radmeas.2012.08.005  0.03
2010 Klein DC, Latz E, Espevik T, Stokke BT. Higher order structure of short immunostimulatory oligonucleotides studied by atomic force microscopy. Ultramicroscopy. 110: 689-93. PMID 20202756 DOI: 10.1016/j.ultramic.2010.02.033  0.028
2018 Parast L, Tucker JS, Pedersen ER, Klein D. Utilization and Perceptions of Drop-in Center Services Among Youth Experiencing Homelessness. The Journal of Behavioral Health Services & Research. PMID 30291586 DOI: 10.1007/S11414-018-9632-9  0.028
2019 McManus MM, Oates RP, Subbiah S, Klein D, Cañas-Carrell JE. Matrix-matched standards in the liquid chromatography-mass spectrometry determination of neonicotinoids in soil and sediment. Journal of Chromatography. A. PMID 31147157 DOI: 10.1016/J.Chroma.2019.05.035  0.024
1976 Klein DC, Fencil-Morse E, Seligman ME. Learned helplessness, depression, and the attribution of failure. Journal of Personality and Social Psychology. 33: 508-16. PMID 1271223 DOI: 10.1037//0022-3514.33.5.508  0.024
2011 Topolovec-Vranic J, Pollmann-Mudryj MA, Ouchterlony D, Klein D, Spence J, Romaschin A, Rhind S, Tien HC, Baker AJ. The value of serum biomarkers in prediction models of outcome after mild traumatic brain injury. The Journal of Trauma. 71: S478-86. PMID 22072007 DOI: 10.1097/TA.0b013e318232fa70  0.024
1957 Montandon A, Franceschetti A, Klein D. Alternance phénotypique d'une hérédo-dégénérescence des voies cochléo-vestibulaires avec une dégénérescence tapéto-rétinienne Stereotactic and Functional Neurosurgery. 17: 1-9. DOI: 10.1159/000105169  0.023
2020 Bauer N, Bertram C, Schultes A, Klein D, Luderer G, Kriegler E, Popp A, Edenhofer O. Quantification of an efficiency-sovereignty trade-off in climate policy. Nature. 588: 261-266. PMID 33299193 DOI: 10.1038/s41586-020-2982-5  0.023
2022 Starmer HM, Klein D, Montgomery A, Goldsmith T, McCarroll L, Richmon J, Christopher Holsinger F, Beadle B, Jain P. Head and Neck Virtual Coach: A Randomized Control Trial of Mobile Health as an Adjunct to Swallowing Therapy During Head and Neck Radiation. Dysphagia. PMID 35960394 DOI: 10.1007/s00455-022-10506-5  0.022
2003 Klein D, Myhill W, Hansen L, Asby G, Michaelson S, Blanck P. Electronic doors to education: study of high school website accessibility in Iowa. Behavioral Sciences & the Law. 21: 27-49. PMID 12579616 DOI: 10.1002/bsl.521  0.022
2016 Kasumba J, Hettick B, French A, Wickliffe JK, Lichtveld MY, Hawkins WB, van Sauers-Muller A, Klein D. Analysis of Pesticides and Toxic Heavy Metals Contained in Mosquito Coils. Bulletin of Environmental Contamination and Toxicology. PMID 27699449 DOI: 10.1007/S00128-016-1938-9  0.021
2021 Connors KA, Abbott S, Jair K, Daniels J, Lintner M, Klein D, Wimpleberg A, Jordan JA. Cross Comparison of AmpFire HPV Genotyping Assay and Roche Human Papillomavirus (HPV) Linear Array for HPV Genotyping of Anal Swab Samples. Journal of Virological Methods. 114113. PMID 33652016 DOI: 10.1016/j.jviromet.2021.114113  0.02
2003 Blanck P, Ritchie H, Schmeling J, Klein D. Technology for independence: a community-based resource center. Behavioral Sciences & the Law. 21: 51-62. PMID 12579617 DOI: 10.1002/bsl.522  0.02
1976 Klein DC, Seligman ME. Reversal of performance deficits and perceptual deficits in learned helplessness and depression. Journal of Abnormal Psychology. 85: 11-26. PMID 1245640 DOI: 10.1037//0021-843x.85.1.11  0.019
2006 Papia G, Klein D, Lindsay TF. Intensive care of the patient following open abdominal aortic surgery. Current Opinion in Critical Care. 12: 340-5. PMID 16810045 DOI: 10.1097/01.ccx.0000235212.86859.54  0.018
2017 Korf HW, Klein DC, Arendt J, Pévet P. Andreas Oksche. Journal of Biological Rhythms. 32: 99-100. PMID 28470124 DOI: 10.1177/0748730417703558  0.016
1978 Klein DC. Some reflections on community control: a commentary on Nassi. Journal of Community Psychology. 6: 16-8. PMID 10306097  0.016
1998 Shung J, Avidan MS, Ing R, Klein DC, Pott L. Awake intubation of the difficult airway with the intubating laryngeal mask airway. Anaesthesia. 53: 645-9. PMID 9771172  0.014
2003 Hay JL, Ford JS, Klein D, Primavera LH, Buckley TR, Stein TR, Shike M, Ostroff JS. Adherence to colorectal cancer screening in mammography-adherent older women. Journal of Behavioral Medicine. 26: 553-76. PMID 14677212 DOI: 10.1023/A:1026253802962  0.014
2012 Wald R, Friedrich JO, Bagshaw SM, Burns KE, Garg AX, Hladunewich MA, House AA, Lapinsky S, Klein D, Pannu NI, Pope K, Richardson RM, Thorpe K, Adhikari NK. Optimal Mode of clearance in critically ill patients with Acute Kidney Injury (OMAKI)--a pilot randomized controlled trial of hemofiltration versus hemodialysis: a Canadian Critical Care Trials Group project. Critical Care (London, England). 16: R205. PMID 23095370 DOI: 10.1186/cc11835  0.014
2021 Thompson KA, Klein D, Alaia MJ, Strauss EJ, Jazrawi LM, Campbell KA. Opioid Use Is Reduced in Patients Treated with NSAIDs After Arthroscopic Bankart Repair: A Randomized Controlled Study. Arthroscopy, Sports Medicine, and Rehabilitation. 3: e15-e22. PMID 33615243 DOI: 10.1016/j.asmr.2020.08.003  0.013
2015 Kitchlu A, Adhikari N, Burns KE, Friedrich JO, Garg AX, Klein D, Richardson RM, Wald R. Outcomes of sustained low efficiency dialysis versus continuous renal replacement therapy in critically ill adults with acute kidney injury: a cohort study. Bmc Nephrology. 16: 127. PMID 26238520 DOI: 10.1186/s12882-015-0123-4  0.013
2004 Ko CY, Escarce JJ, Baker L, Klein D, Guarino C. Predictors for medical students entering a general surgery residency: National survey results. Surgery. 136: 567-72. PMID 15349103 DOI: 10.1016/J.Surg.2004.05.021  0.012
2012 Odutayo A, Adhikari NK, Barton J, Burns KE, Friedrich JO, Klein D, Lapinsky S, Litwin S, Meret A, Moineddin R, Richardson B, Richardson R, Zaltzman A, Hladunewich M, Wald R. Epidemiology of acute kidney injury in Canadian critical care units: a prospective cohort study. Canadian Journal of Anaesthesia = Journal Canadien D'Anesthã©Sie. 59: 934-42. PMID 22843289 DOI: 10.1007/s12630-012-9761-1  0.012
1992 Klein DC. Managing humiliation. The Journal of Primary Prevention. 12: 255-68. PMID 24293190 DOI: 10.1007/BF03337910  0.011
2011 Corvalan J, Klein D. Post traumatic stress disorder: part II. Missouri Medicine. 108: 366-72. PMID 22073497  0.01
2014 TAVONI M, KRIEGLER E, ABOUMAHBOUB T, CALVIN K, DE MAERE G, WISE M, KLEIN D, JEWELL J, KOBER T, LUCAS P, LUDERER G, McCOLLUM D, MARANGONI G, RIAHI K, VAN VUUREN D. ERRATUM: "THE DISTRIBUTION OF THE MAJOR ECONOMIES' EFFORT IN THE DURBAN PLATFORM SCENARIOS" Climate Change Economics. 5: 1492001. DOI: 10.1142/S2010007814920018  0.01
2010 Wang LL, Klein D, Beddar AS. Monte Carlo study of the energy and angular dependence of the response of plastic scintillation detectors in photon beams. Medical Physics. 37: 5279-86. PMID 21089762 DOI: 10.1118/1.3488904  0.01
2006 Stein BD, Meili R, Klein D. Datapoints: general medical costs of recipients of behavioral health care. Psychiatric Services (Washington, D.C.). 57: 620. PMID 16675753 DOI: 10.1176/ps.2006.57.5.620  0.01
2000 Klein DC. Ending the war on drugs: A serious challenge for the field of prevention Journal of Primary Prevention. 21: 147-149. DOI: 10.1023/A:1007070800554  0.01
2000 Klein DC. Web strategies for professional publishers: Developing an information services portal Learned Publishing. 13: 83-94.  0.01
1996 KLEIN DC, LINDEMANN E. APPROACHES TO PRE-SCHOOL SCREENING. The Journal of School Health. 34: 365-73. PMID 14199395 DOI: 10.1111/j.1746-1561.1964.tb01578.x  0.01
1992 Klein DC. Introduction to the issue. The Journal of Primary Prevention. 12: 189-93. PMID 24258265 DOI: 10.1007/BF02015513  0.01
1991 Klein DC. The humiliation dynamic: An overview. The Journal of Primary Prevention. 12: 93-121. PMID 24258218 DOI: 10.1007/BF02015214  0.01
1991 Klein DC. Introduction to the issue. The Journal of Primary Prevention. 12: 87-91. PMID 24258217 DOI: 10.1007/BF02015213  0.01
1980 Klein D. Dr. Petrus Johannes Waardenburg 3 June 1886 – 23 September 1979 Acta Geneticae Medicae Et Gemellologiae: Twin Research. 29: 167-168. DOI: 10.1017/s0001566000008667  0.01
1956 Franceschetti A, Marty F, Klein D. Un syndrome rare: Hérédoataxie avec cataracte congénitale et retard mental Stereotactic and Functional Neurosurgery. 16: 271-275. DOI: 10.1159/000105308  0.01
1955 Klein D, Franceschetti A, Babel J. Les manifestation oculaires des troubles primitifs du metabolisme des lipides: Étude clinique, génétique et anatomo-pathologique Arquivos De Neuro-Psiquiatria. 13: 69-160. DOI: 10.1590/S0004-282X1955000200001  0.01
1947 Franceschetti A, Klein D. Rétinite dominante avec surdité Stereotactic and Functional Neurosurgery. 8: 339-342. DOI: 10.1159/000105910  0.01
1947 Franceschetti A, Walthard K, Klein D. Effets thérapeutiques de la quinine dans la dystrophie myotonique Stereotactic and Functional Neurosurgery. 8: 247-248. DOI: 10.1159/000105896  0.01
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