Thomas C. Irving - Publications

Affiliations: 
Illinois Institute of Technology, Chicago, IL, United States 
Area:
Anatomy Biology, General Biophysics

181 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2024 Jani VP, Song T, Gao C, Gong H, Sadayappan S, Kass DA, Irving TC, Ma W. The structural OFF and ON states of myosin can be decoupled from the biochemical super- and disordered-relaxed states. Pnas Nexus. 3: pgae039. PMID 38328779 DOI: 10.1093/pnasnexus/pgae039  0.314
2023 Song T, McNamara JW, Baby A, Ma W, Landim-Vieira M, Natesan S, Pinto JR, Lorenz JN, Irving TC, Sadayappan S. Unlocking the Role of sMyBP-C: A Key Player in Skeletal Muscle Development and Growth. Biorxiv : the Preprint Server For Biology. PMID 38076858 DOI: 10.1101/2023.10.23.563591  0.307
2023 Hessel AL, Kuehn MN, Engels NM, Nissen DL, Freundt JK, Ma W, Irving TC, Linke WA. Titin-based force regulates cardiac myofilament structures mediating length-dependent activation. Biorxiv : the Preprint Server For Biology. PMID 38014235 DOI: 10.1101/2023.11.09.566413  0.379
2023 Hessel AL, Kuehn M, Han SW, Ma W, Irving TC, Momb BA, Song T, Sadayappan S, Linke WA, Palmer BM. Fast myosin binding protein C knockout in skeletal muscle alters length-dependent activation and myofilament structure. Biorxiv : the Preprint Server For Biology. PMID 37961718 DOI: 10.1101/2023.10.19.563160  0.416
2023 Ma W, Jani VP, Song T, Gao C, Gong H, Sadayappan S, Kass DA, Irving TC. The structural OFF and ON states of myosin can be decoupled from the biochemical super-relaxed and disordered-relaxed states. Biorxiv : the Preprint Server For Biology. PMID 37904972 DOI: 10.1101/2023.10.18.562891  0.314
2023 Rodriguez Garcia M, Schmeckpeper J, Landim-Vieira M, Coscarella IL, Fang X, Ma W, Spran PA, Yuan S, Qi L, Kahmini AR, Shoemaker MB, Atkinson JB, Kekenes-Huskey PM, Irving TC, Chase PB, et al. Disruption of Z-Disc Function Promotes Mechanical Dysfunction in Human Myocardium: Evidence for a Dual Myofilament Modulatory Role by Alpha-Actinin 2. International Journal of Molecular Sciences. 24. PMID 37834023 DOI: 10.3390/ijms241914572  0.35
2023 Hessel AL, Engels NM, Kuehn M, Nissen D, Sadler RL, Ma W, Irving TC, Linke WA, Harris SP. Myosin-binding protein C forms C-links and stabilizes OFF states of myosin. Biorxiv : the Preprint Server For Biology. PMID 37745361 DOI: 10.1101/2023.09.10.556972  0.373
2023 Kooiker KB, Mohran S, Turner KL, Ma W, Martinson A, Flint G, Qi L, Gao C, Zheng Y, McMillen TS, Mandrycky C, Mahoney-Schaefer M, Freeman JC, Costales Arenas EG, Tu AY, ... Irving TC, et al. Danicamtiv Increases Myosin Recruitment and Alters Cross-Bridge Cycling in Cardiac Muscle. Circulation Research. PMID 37470183 DOI: 10.1161/CIRCRESAHA.123.322629  0.313
2023 Landim-Vieira M, Ma W, Song T, Rastegarpouyani H, Gong H, Coscarella IL, Bogaards SJP, Conijn SP, Ottenheijm CAC, Hwang HS, Papadaki M, Knollmann BC, Sadayappan S, Irving TC, Galkin VE, et al. Cardiac troponin T N-domain variant destabilizes the actin interface resulting in disturbed myofilament function. Proceedings of the National Academy of Sciences of the United States of America. 120: e2221244120. PMID 37252999 DOI: 10.1073/pnas.2221244120  0.353
2023 Prodanovic M, Wang Y, Mijailovich SM, Irving T. Using Multiscale Simulations as a Tool to Interpret Equatorial X-ray Fiber Diffraction Patterns from Skeletal Muscle. International Journal of Molecular Sciences. 24. PMID 37239821 DOI: 10.3390/ijms24108474  0.35
2023 Hessel AL, Kuehn M, Palmer BM, Nissen D, Mishra D, Joumaa V, Freundt J, Ma W, Nishikawa KC, Irving T, Linke WA. The distinctive mechanical and structural signatures of residual force enhancement in myofibers. Biorxiv : the Preprint Server For Biology. PMID 36865266 DOI: 10.1101/2023.02.19.529125  0.391
2023 Ma W, McMillen TS, Childers MC, Gong H, Regnier M, Irving T. Structural OFF/ON transitions of myosin in relaxed porcine myocardium predict calcium-activated force. Proceedings of the National Academy of Sciences of the United States of America. 120: e2207615120. PMID 36696446 DOI: 10.1073/pnas.2207615120  0.352
2022 Awinda PO, Ma W, Turner KL, Zhao J, Gong H, Thompson MS, Campbell KS, Irving TC, Tanner BCW. MgADP Promotes Myosin Head Movement toward Actin at Low [Ca] to Increase Force Production and Ca-Sensitivity of Contraction in Permeabilized Porcine Myocardial Strips. International Journal of Molecular Sciences. 23. PMID 36499408 DOI: 10.3390/ijms232315084  0.35
2022 Jani V, Qian W, Yuan S, Irving T, Ma W. EMD-57033 Augments the Contractility in Porcine Myocardium by Promoting the Activation of Myosin in Thick Filaments. International Journal of Molecular Sciences. 23. PMID 36498844 DOI: 10.3390/ijms232314517  0.379
2022 Hessel AL, Ma W, Mazara N, Rice PE, Nissen D, Gong H, Kuehn M, Irving T, Linke WA. Titin force in muscle cells alters lattice order, thick and thin filament protein formation. Proceedings of the National Academy of Sciences of the United States of America. 119: e2209441119. PMID 36409887 DOI: 10.1073/pnas.2209441119  0.42
2022 Gong HM, Ma W, Regnier M, Irving TC. Thick filament activation is different in fast and slow-twitch skeletal muscle. The Journal of Physiology. PMID 36342015 DOI: 10.1113/JP283574  0.387
2022 Ma W, Nag S, Gong H, Qi L, Irving TC. Cardiac myosin filaments are directly regulated by calcium. The Journal of General Physiology. 154. PMID 36327149 DOI: 10.1085/jgp.202213213  0.375
2022 Ma W, Irving TC. Small Angle X-ray Diffraction as a Tool for Structural Characterization of Muscle Disease. International Journal of Molecular Sciences. 23. PMID 35328477 DOI: 10.3390/ijms23063052  0.337
2022 Yuan CC, Kazmierczak K, Liang J, Ma W, Irving TC, Szczesna-Cordary D. Molecular basis of force-pCa relation in cardiomyopathy mice: Role of the super-relaxed state of myosin. Proceedings of the National Academy of Sciences of the United States of America. 119. PMID 35177471 DOI: 10.1073/pnas.2110328119  0.333
2021 Joumaa V, Smith IC, Fukutani A, Leonard TR, Ma W, Mijailovich SM, Irving TC, Herzog W. Effect of Active Lengthening and Shortening on Small-Angle X-ray Reflections in Skinned Skeletal Muscle Fibres. International Journal of Molecular Sciences. 22. PMID 34445232 DOI: 10.3390/ijms22168526  0.363
2021 Cass JA, Williams CD, Irving TC, Lauga E, Malingen S, Daniel TL, Sponberg SN. A mechanism for sarcomere breathing: volume change and advective flow within the myofilament lattice. Biophysical Journal. PMID 34384761 DOI: 10.1016/j.bpj.2021.08.006  0.342
2021 Ma W, Henze M, Anderson RL, Gong HM, Wong FL, Del Rio CL, Irving TC. The Super-Relaxed State and Length Dependent Activation in Porcine Myocardium. Circulation Research. PMID 34365814 DOI: 10.1161/CIRCRESAHA.120.318647  0.445
2021 Trujillo AS, Hsu KH, Puthawala J, Viswanathan MC, Loya A, Irving TC, Cammarato A, Swank DM, Bernstein SI. Myosin dilated cardiomyopathy mutation S532P disrupts actomyosin interactions, leading to altered muscle kinetics, reduced locomotion, and cardiac dilation in . Molecular Biology of the Cell. mbcE21020088. PMID 34081531 DOI: 10.1091/mbc.E21-02-0088  0.31
2021 Song T, McNamara JW, Ma W, Landim-Vieira M, Lee KH, Martin LA, Heiny JA, Lorenz JN, Craig R, Pinto JR, Irving T, Sadayappan S. Fast skeletal myosin-binding protein-C regulates fast skeletal muscle contraction. Proceedings of the National Academy of Sciences of the United States of America. 118. PMID 33888578 DOI: 10.1073/pnas.2003596118  0.396
2021 Rahmani H, Ma W, Hu Z, Daneshparvar N, Taylor DW, McCammon JA, Irving TC, Edwards RJ, Taylor KA. The myosin II coiled-coil domain atomic structure in its native environment. Proceedings of the National Academy of Sciences of the United States of America. 118. PMID 33782130 DOI: 10.1073/pnas.2024151118  0.302
2021 van de Locht M, Donkervoort S, de Winter JM, Conijn S, Begthel L, Kusters B, Mohassel P, Hu Y, Medne L, Quinn C, Moore SA, Foley AR, Seo G, Hwee DT, Malik FI, ... Irving T, et al. Pathogenic variants in TNNC2 cause congenital myopathy due to an impaired force response to calcium. The Journal of Clinical Investigation. PMID 33755597 DOI: 10.1172/JCI145700  0.33
2021 Ma W, Duno-Miranda S, Irving T, Craig R, Padrón R. Relaxed tarantula skeletal muscle has two ATP energy-saving mechanisms. The Journal of General Physiology. 153. PMID 33480967 DOI: 10.1085/jgp.202012780  0.305
2021 Caremani M, Fusi L, Linari M, Reconditi M, Piazzesi G, Irving TC, Narayanan T, Irving M, Lombardi V, Brunello E. Dependence of thick filament structure in relaxed mammalian skeletal muscle on temperature and interfilament spacing. The Journal of General Physiology. 153. PMID 33416833 DOI: 10.1085/jgp.202012713  0.412
2020 Ma W, Childers M, Murray J, Moussavi-Harami F, Gong H, Weiss R, Daggett V, Irving T, Regnier M. Myosin dynamics during relaxation in mouse soleus muscle and modulation by 2'-deoxy-ATP. The Journal of Physiology. PMID 32818298 DOI: 10.1113/Jp280402  0.504
2020 Gong H, Ma W, Chen S, Wang G, Khairallah R, Irving T. Localization of the Elastic Proteins in the Flight Muscle of . International Journal of Molecular Sciences. 21. PMID 32752103 DOI: 10.3390/Ijms21155504  0.467
2020 Malingen SA, Asencio AM, Cass JA, Ma W, Irving TC, Daniel TL. x-ray diffraction and simultaneous EMG reveal the time course of myofilament lattice dilation and filament stretch. The Journal of Experimental Biology. PMID 32709625 DOI: 10.1242/jeb.224188  0.327
2020 Lindqvist J, Ma W, Li F, Hernandez Y, Kolb J, Kiss B, Tonino P, van der Pijl R, Karimi E, Gong H, Strom J, Hourani Z, Smith JE, Ottenheijm C, Irving T, et al. Triggering typical nemaline myopathy with compound heterozygous nebulin mutations reveals myofilament structural changes as pathomechanism. Nature Communications. 11: 2699. PMID 32483185 DOI: 10.1038/S41467-020-16526-9  0.432
2020 Padrón R, Ma W, Duno-Miranda S, Koubassova N, Lee KH, Pinto A, Alamo L, Bolaños P, Tsaturyan A, Irving T, Craig R. The myosin interacting-heads motif present in live tarantula muscle explains tetanic and posttetanic phosphorylation mechanisms. Proceedings of the National Academy of Sciences of the United States of America. PMID 32444484 DOI: 10.1073/Pnas.1921312117  0.517
2020 Tune TC, Ma W, Irving T, Sponberg S. Nanometer-scale structure differences in the myofilament lattice spacing of two cockroach leg muscles correspond to their different functions. The Journal of Experimental Biology. PMID 32205362 DOI: 10.1242/Jeb.212829  0.48
2020 Padron R, Ma W, Duno Miranda S, Koubassova N, Lee K, Tiwari P, Pinto A, Bolaños P, Tsaturyan A, Irving TC, Craig R. Thick Filament Activation and Post-Tetanic Potentiation Mechanisms Evolved Differently in Invertebrate and Vertebrate Striated Muscle Biophysical Journal. 118: 496a. DOI: 10.1016/J.Bpj.2019.11.2743  0.432
2020 Vieira ML, Ma W, Johnston J, Chase PB, Irving TC, Pinto JRD. Measurements of Actin Layer Lines in Permeabilized Heart Tissue Reveal New Structural Properties of the Cardiac Thin Filament Biophysical Journal. 118: 426a. DOI: 10.1016/J.Bpj.2019.11.2397  0.331
2020 Ma W, Nag S, Chakravarthy S, Gollapudi S, Sa N, Tomasic I, Irving TC. Effects of Mavacamten and Blebbistatin on the Small-Angle X-ray Scattering Structure of Human β-cardiac Myosin Biophysical Journal. 118: 422a. DOI: 10.1016/J.Bpj.2019.11.2378  0.351
2020 Mohran S, Yuan C, Luttrell SM, Ma W, Irving TC, Mack DL, Regnier M. Development of Mechanical and Structural Dysfunction in Skeletal Muscle from a Duchene Muscular Dystrophy Rat Model Biophysical Journal. 118: 277a-278a. DOI: 10.1016/J.Bpj.2019.11.1590  0.388
2019 Mijailovich SM, Prodanovic M, Irving TC. Estimation of Forces on Actin Filaments in Living Muscle from X-ray Diffraction Patterns and Mechanical Data. International Journal of Molecular Sciences. 20. PMID 31801239 DOI: 10.3390/Ijms20236044  0.503
2019 Ma W, Lee KH, Yang S, Irving TC, Craig R. Lattice arrangement of myosin filaments correlates with fiber type in rat skeletal muscle. The Journal of General Physiology. PMID 31699797 DOI: 10.1085/Jgp.201912460  0.367
2019 de Winter JM, Molenaar JP, Yuen M, van der Pijl R, Shen S, Conijn S, van de Locht M, Willigenburg M, Bogaards SJ, van Kleef ES, Lassche S, Persson M, Rassier DE, Sztal TE, Ruparelia AA, ... Irving T, et al. KBTBD13 is an actin-binding protein that modulates muscle kinetics. The Journal of Clinical Investigation. PMID 31671076 DOI: 10.1172/Jci124000  0.471
2019 Caremani M, Brunello E, Linari M, Fusi L, Irving TC, Gore D, Piazzesi G, Irving M, Lombardi V, Reconditi M. Low temperature traps myosin motors of mammalian muscle in a refractory state that prevents activation. The Journal of General Physiology. PMID 31554652 DOI: 10.1085/Jgp.201912424  0.421
2019 Ma W, Irving TC. X-ray Diffraction of Intact Murine Skeletal Muscle as a Tool for Studying the Structural Basis of Muscle Disease. Journal of Visualized Experiments : Jove. PMID 31380854 DOI: 10.3791/59559  0.439
2019 Powers JD, Yuan CC, McCabe KJ, Murray JD, Childers MC, Flint GV, Moussavi-Harami F, Mohran S, Castillo R, Zuzek C, Ma W, Daggett V, McCulloch AD, Irving TC, Regnier M. Cardiac myosin activation with 2-deoxy-ATP via increased electrostatic interactions with actin. Proceedings of the National Academy of Sciences of the United States of America. PMID 31110001 DOI: 10.1073/Pnas.1905028116  0.496
2019 Mijailovich SM, Stojanovic B, Nedic D, Svicevic M, Geeves MA, Irving TC, Granzier HL. Nebulin and titin modulate cross-bridge cycling and length-dependent calcium sensitivity. The Journal of General Physiology. PMID 30948421 DOI: 10.1085/Jgp.201812165  0.507
2019 Ma W, Gong H, Kiss B, Lee EJ, Granzier H, Irving T. Response to: Thick Filament Length Changes in Muscle Have Both Elastic and Structural Components. Biophysical Journal. PMID 30850114 DOI: 10.1016/J.Bpj.2019.02.010  0.425
2019 Irving TC, Craig R. Getting into the thick (and thin) of it. The Journal of General Physiology. PMID 30792184 DOI: 10.1085/Jgp.201812307  0.429
2019 Henze M, Ma W, Wong F, Gong H, Anderson R, Rio Cd, Irving TC. Abstract 905: Length Dependent Activation in Porcine Cardiac Myofilaments is Modulated by Mavacamten Circulation Research. 125. DOI: 10.1161/Res.125.Suppl_1.905  0.318
2019 Yuan C, Powers JD, McCabe KJ, Murray JD, Saffie M, Romi C, Carla Z, Ma W, McCulloch AD, Irving TC, Regnier M. Enhanced Crossbridge Binding with 2-Deoxy-ATP Results from Increased Electrostatic Interactions between Myosin and Actin in Cardiac Muscle Biophysical Journal. 116: 466a. DOI: 10.1016/J.Bpj.2018.11.2518  0.445
2019 Yuan C, Powers JD, Murray J, Mohran S, Ma W, Luttrell SM, Irving TC, Regnier M, Mack DL. Time-Resolved X-Ray Studies of Skeletal Muscle from a Duchene Muscular Dystrophy Rat Model Biophysical Journal. 116: 404a. DOI: 10.1016/J.Bpj.2018.11.2183  0.417
2019 Ma W, Childers MC, Murray JD, Gong H, Daggett V, Irving TC, Regnier M. Time-Resolved X-Ray Diffraction and Molecular Dynamics Studies of Skeletal Muscle Relaxation with 2 Deoxy-ATP Biophysical Journal. 116: 403a-404a. DOI: 10.1016/J.Bpj.2018.11.2180  0.429
2019 Tune T, Irving T, Sponberg S. X-Ray Diffraction Resolves How Actin-Myosin Spacing Explains the Differences of Two Muscles with Identical Steady State Properties Biophysical Journal. 116: 403a. DOI: 10.1016/J.Bpj.2018.11.2179  0.469
2019 Ma W, Anderson R, Henze M, Gong H, Wong F, Rio Cd, Irving T. Myofilament Length Dependent Activation in Porcine Cardiac Muscle Biophysical Journal. 116. DOI: 10.1016/J.Bpj.2018.11.1426  0.432
2018 Kazmierczak K, Liang J, Yuan CC, Yadav S, Sitbon YH, Walz K, Ma W, Irving TC, Cheah JX, Gomes AV, Szczesna-Cordary D. Slow-twitch skeletal muscle defects accompany cardiac dysfunction in transgenic mice with a mutation in the myosin regulatory light chain. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. fj201801402R. PMID 30365366 DOI: 10.1096/Fj.201801402R  0.461
2018 Ma W, Gong H, Kiss B, Lee EJ, Granzier H, Irving T. Thick-Filament Extensibility in Intact Skeletal Muscle. Biophysical Journal. PMID 30266320 DOI: 10.1016/J.Bpj.2018.08.038  0.48
2018 Kiss B, Lee EJ, Ma W, Li FW, Tonino P, Mijailovich SM, Irving TC, Granzier HL. Nebulin stiffens the thin filament and augments cross-bridge interaction in skeletal muscle. Proceedings of the National Academy of Sciences of the United States of America. PMID 30249654 DOI: 10.1073/Pnas.1804726115  0.499
2018 Ma W, Gong H, Irving T. Myosin Head Configurations in Resting and Contracting Murine Skeletal Muscle. International Journal of Molecular Sciences. 19. PMID 30200618 DOI: 10.3390/Ijms19092643  0.484
2018 Gonzalez-Martinez D, Johnston JR, Landim-Vieira M, Ma W, Antipova O, Awan O, Irving TC, Bryant Chase P, Pinto JR. Structural and functional impact of troponin C-mediated Ca2+ sensitization on myofilament lattice spacing and cross-bridge mechanics in mouse cardiac muscle. Journal of Molecular and Cellular Cardiology. PMID 30138628 DOI: 10.1016/J.Yjmcc.2018.08.015  0.468
2018 Anderson RL, Trivedi DV, Sarkar SS, Henze M, Ma W, Gong H, Rogers CS, Gorham JM, Wong FL, Morck MM, Seidman JG, Ruppel KM, Irving TC, Cooke R, Green EM, et al. Deciphering the super relaxed state of human β-cardiac myosin and the mode of action of mavacamten from myosin molecules to muscle fibers. Proceedings of the National Academy of Sciences of the United States of America. PMID 30104387 DOI: 10.1073/Pnas.1809540115  0.439
2018 Yuan CC, Kazmierczak K, Liang J, Zhou Z, Yadav S, Gomes AV, Irving TC, Szczesna-Cordary D. Sarcomeric perturbations of myosin motors lead to dilated cardiomyopathy in genetically modifiedmice. Proceedings of the National Academy of Sciences of the United States of America. PMID 29463717 DOI: 10.1073/Pnas.1716925115  0.378
2018 Joureau B, de Winter JM, Conijn S, Bogaards SJP, Kovacevic I, Kalganov A, Persson M, Lindqvist J, Stienen GJM, Irving TC, Ma W, Yuen M, Clarke NF, Rassier DE, Malfatti E, et al. Dysfunctional sarcomere contractility contributes to muscle weakness in ACTA1-related nemaline myopathy (NEM3). Annals of Neurology. PMID 29328520 DOI: 10.1002/Ana.25144  0.413
2018 Malaby AW, Das S, Chakravarthy S, Irving TC, Bilsel O, Lambright DG. Structural Dynamics Control Allosteric Activation of Cytohesin Family Arf GTPase Exchange Factors. Structure (London, England : 1993). 26: 106-117.e6. PMID 29276036 DOI: 10.1016/J.Str.2017.11.019  0.302
2018 Jiratrakanvong J, Ma W, Agam G, Irving TC. MuscleX: a new tool for analyzing X-ray diffraction patterns from muscle and other fibrous systems Acta Crystallographica Section a Foundations and Advances. 74: a129-a129. DOI: 10.1107/S0108767318098707  0.402
2018 Joumaa V, Smith IC, Fakutani A, Leonard T, Ma W, Irving T, Herzog W. Evidence for Actin Filament Structural Changes after Active Shortening in Skinned Muscle Bundles Biophysical Journal. 114. DOI: 10.1016/J.Bpj.2017.11.765  0.438
2018 Kiss B, Lee E, Ma W, Li F, Tonino P, Mijailovich SM, Irving T, Granzier H. Nebulin Stiffens the Thin Filament and Augments Crossbridge Interaction - An X-Ray Diffraction Study on Intact Muscle Biophysical Journal. 114: 645a. DOI: 10.1016/J.Bpj.2017.11.3482  0.451
2018 Hsu KH, Trujillo A, Irving TC, Bernstein SI. Structural and Biochemical Mechanisms of Myosin-Induced Dilated Cardiomyopathy Biophysical Journal. 114: 383a. DOI: 10.1016/J.Bpj.2017.11.2119  0.337
2018 Landim-Vieira M, Gonzalez-Martinez D, Johnston JR, Ma W, Antipova O, Awan O, Chase PB, Irving T, Pinto JR. Cardiac Thin Filament-Mediated Calcium Sensitization Modulates Cross-Bridge Kinetics Biophysical Journal. 114: 315a-316a. DOI: 10.1016/J.Bpj.2017.11.1777  0.316
2017 Yuan CC, Kazmierczak K, Liang J, Kanashiro-Takeuchi R, Irving TC, Gomes AV, Wang Y, Burghardt TP, Szczesna-Cordary D. Hypercontractile mutant of ventricular myosin essential light chain leads to disruption of sarcomeric structure and function and results in restrictive cardiomyopathy in mice. Cardiovascular Research. PMID 28371863 DOI: 10.1093/Cvr/Cvx060  0.336
2017 Mijailovich SM, Nedic D, Stojanovic B, Irving TC, Geeves MA. Modulation of Fast Transients by Compliance of Crossbridges and Myofilaments Biophysical Journal. 112: 115a. DOI: 10.1016/J.Bpj.2016.11.649  0.395
2017 Gonzalez-Martinez D, Landim-Vieira M, Johnston J, Ma W, Griffin B, Antipova O, Awan O, Chase PB, Irving T, Pinto JR. Thin Filament-Mediated Modulation of Mouse Cardiac Cross-Bridge Kinetics by Ca 2+ -Sensitizing Mutation CTNC-A8V or Bepridil Biophysical Journal. 112: 559a. DOI: 10.1016/J.Bpj.2016.11.3012  0.433
2017 Yuan C, Liang J, Kazmierczak K, Zhou Z, Kanashiro-Takeuchi R, Irving TC, Szczesna-Cordary D. Distinct Lattice Structure Altreations in DCM and HCM Mouse Models Associated with Mutations in Myosin Regulatory Light Chain Biophysical Journal. 112. DOI: 10.1016/J.Bpj.2016.11.3009  0.419
2017 Szczesna-Cordary D, Yuan C, Kazmierczak K, Zhou Z, Liang J, Yadav S, Irving TC, Cheah JX, Gomes AV. Molecular Mechanisms Involved in Cardioskeletal Dysfunction Caused by Mutations in Myosin RLC Linked to Hypertrophic Cardiomyopathy Biophysical Journal. 112. DOI: 10.1016/J.Bpj.2016.11.3008  0.467
2017 Ma W, Buck D, Nedrud J, Irving TC, Granzier H. Thick Filament Compliance in Passively Stretched Skeletal Muscle Biophysical Journal. 112. DOI: 10.1016/J.Bpj.2016.11.1005  0.519
2016 Mijailovich SM, Kayser-Herold O, Stojanovic B, Nedic D, Irving TC, Geeves MA. Three-dimensional stochastic model of actin-myosin binding in the sarcomere lattice. The Journal of General Physiology. PMID 27864330 DOI: 10.1085/Jgp.201611608  0.433
2016 Prodanovic M, Irving TC, Mijailovich SM. X-ray diffraction from nonuniformly stretched helical molecules. Journal of Applied Crystallography. 49: 784-797. PMID 27275136 DOI: 10.1107/S1600576716003757  0.421
2016 Ait-Mou Y, Hsu K, Farman GP, Kumar M, Greaser ML, Irving TC, de Tombe PP. Titin strain contributes to the Frank-Starling law of the heart by structural rearrangements of both thin- and thick-filament proteins. Proceedings of the National Academy of Sciences of the United States of America. PMID 26858417 DOI: 10.1073/Pnas.1516732113  0.775
2016 Gonzalez-Martinez D, Landim-Vieira M, Antipova OA, Awan O, Chase PB, Irving T, Pinto JR. Simultaneous Measurement of Force and Lattice Spacing in Skinned Cardiac Fibers Biophysical Journal. 110: 120a. DOI: 10.1016/J.Bpj.2015.11.698  0.44
2016 Kazmierczak K, Yuan C, Kanashiro-Takeuchi R, Liang J, Zhou Z, Cheah JX, Gilda JE, Gomes AV, Irving TC, Szczesna-Cordary D. Development of Physiologic versus Pathologic Hypertrophy in Mouse Models Expressing Mutations in Myosin Essential Light Chain Biophysical Journal. 110. DOI: 10.1016/J.Bpj.2015.11.2556  0.359
2016 Joumaa V, Smith IC, Leonard TR, Antipova O, Irving TC, Herzog W. Effect of Active Shortening and Stretching on Lattice Spacing and Cross-Bridge Binding in Skinned Muscle Fibres Biophysical Journal. 110. DOI: 10.1016/J.Bpj.2015.11.1619  0.438
2016 Yuan C, Liang J, Kazmierczak K, Zhou Z, Kanashiro-Takeuch R, Hare JM, Irving TC, Szczesna-Cordary D. Rare Cardiomyopathy Phenotypes Associated with Mutations in Myosin Light Chains Biophysical Journal. 110. DOI: 10.1016/J.Bpj.2015.11.1604  0.432
2015 Yuan CC, Muthu P, Kazmierczak K, Liang J, Huang W, Irving TC, Kanashiro-Takeuchi RM, Hare JM, Szczesna-Cordary D. Constitutive phosphorylation of cardiac myosin regulatory light chain prevents development of hypertrophic cardiomyopathy in mice. Proceedings of the National Academy of Sciences of the United States of America. PMID 26124132 DOI: 10.1073/Pnas.1505819112  0.352
2015 Yuan CC, Ma W, Schemmel P, Cheng YS, Liu J, Tsaprailis G, Feldman S, Ayme Southgate A, Irving TC. Elastic proteins in the flight muscle of Manduca sexta. Archives of Biochemistry and Biophysics. 568: 16-27. PMID 25602701 DOI: 10.1016/j.abb.2014.12.033  0.419
2015 Prodanovic M, Nedic D, Irving TC, Mijailovich SM. Estimation of Local Forces in Myofilaments using X-Ray Diffraction Patterns and Muscle Mechanics Data Biophysical Journal. 108. DOI: 10.1016/J.Bpj.2014.11.2312  0.495
2015 Nedic D, Svicevic M, Stojanovic B, Geeves MA, Irving T, Gilbert RJ, Mijailovich SM. Effect of Mutations in cMyBP-C on Sarcomere Mechanical Function Biophysical Journal. 108: 200a. DOI: 10.1016/J.Bpj.2014.11.1108  0.478
2014 Hitchcock-DeGregori SE, Irving TC. Hugh E. Huxley: the compleat biophysicist. Biophysical Journal. 107: 1493-501. PMID 25296301 DOI: 10.1016/J.Bpj.2014.07.069  0.492
2014 Nobrega RP, Arora K, Kathuria SV, Graceffa R, Barrea RA, Guo L, Chakravarthy S, Bilsel O, Irving TC, Brooks CL, Matthews CR. Modulation of frustration in folding by sequence permutation. Proceedings of the National Academy of Sciences of the United States of America. 111: 10562-7. PMID 25002512 DOI: 10.1073/Pnas.1324230111  0.323
2014 Witayavanitkul N, Ait Mou Y, Kuster DW, Khairallah RJ, Sarkey J, Govindan S, Chen X, Ge Y, Rajan S, Wieczorek DF, Irving T, Westfall MV, de Tombe PP, Sadayappan S. Myocardial infarction-induced N-terminal fragment of cardiac myosin-binding protein C (cMyBP-C) impairs myofilament function in human myocardium. The Journal of Biological Chemistry. 289: 8818-27. PMID 24509847 DOI: 10.1074/Jbc.M113.541128  0.397
2014 Hsu KH, Ait-Mou Y, Tombe PPd, Irving TC. Titin-Based Modulation of Sarcomere Structure as Revealed by Equatorial X-Ray Diffraction Biophysical Journal. 106. DOI: 10.1016/J.Bpj.2013.11.920  0.475
2014 Yuan C, Muthu P, Kanashiro-Takeuchi R, Liang J, Rojas AI, Kazmierczak K, Hare JM, Irving T, Szczesna-Cordary D. The Structure-Function Analysis of Myosin Pseudo-Phosphorylation in Mouse Model of FHC Biophysical Journal. 106: 771a. DOI: 10.1016/J.Bpj.2013.11.4235  0.409
2014 Hsu KH, Zhang M, Witayavanitkul N, Irving TC, Tombe PPd. Impact of Troponin-I Phosphorylation on Human Cardiac Myofilament Function Biophysical Journal. 106. DOI: 10.1016/J.Bpj.2013.11.4229  0.433
2014 Prodanovic M, Irving TC, McOwen R, Mijailovich SM. X-Ray Diffraction Pattern of Non-Uniformly Stretched Actin Filament Biophysical Journal. 106: 7-8. DOI: 10.1016/J.Bpj.2013.11.4221  0.435
2014 Huang W, Liang J, Kazmierczak K, Muthu P, Yuan C, Rojas AI, Duggal D, Borejdo J, Irving TC, Szczesna-Cordary D. Familial Hypertrophic Cardiomyopathy-Linked Mutation (K104E) in the Myosin Regulatory Light Chain Affects Sarcomeric Structure and Function in Tg-Mice Biophysical Journal. 106: 33a. DOI: 10.1016/J.Bpj.2013.11.254  0.434
2014 Witayavanitkul N, Sarkey J, Aitmou Y, Kuster DW, Khairallah RJ, Govindan S, Chen X, Ge Y, Rajan S, Wieczorek DF, Irving T, de Tombe PP, Sadayappan S. Myocardial Infarction-Induced N-Terminal Fragment of Cmybp-C Impairs Myofilament Function in Human Left Ventricular Myofibrils Biophysical Journal. 106: 347a. DOI: 10.1016/J.Bpj.2013.11.1977  0.413
2013 Graceffa R, Nobrega RP, Barrea RA, Kathuria SV, Chakravarthy S, Bilsel O, Irving TC. Sub-millisecond time-resolved SAXS using a continuous-flow mixer and X-ray microbeam. Journal of Synchrotron Radiation. 20: 820-5. PMID 24121320 DOI: 10.1107/S0909049513021833  0.339
2013 Williams CD, Salcedo MK, Irving TC, Regnier M, Daniel TL. The length-tension curve in muscle depends on lattice spacing. Proceedings. Biological Sciences / the Royal Society. 280: 20130697. PMID 23843386 DOI: 10.1098/Rspb.2013.0697  0.499
2013 George NT, Irving TC, Williams CD, Daniel TL. The cross-bridge spring: can cool muscles store elastic energy? Science (New York, N.Y.). 340: 1217-20. PMID 23618763 DOI: 10.1126/Science.1229573  0.424
2013 Lee EJ, Nedrud J, Schemmel P, Gotthardt M, Irving TC, Granzier HL. Calcium sensitivity and myofilament lattice structure in titin N2B KO mice. Archives of Biochemistry and Biophysics. 535: 76-83. PMID 23246787 DOI: 10.1016/J.Abb.2012.12.004  0.528
2013 Rao VS, Korte FS, Razumova MV, Feest ER, Hsu H, Irving TC, Regnier M, Martyn DA. N-terminal phosphorylation of cardiac troponin-I reduces length-dependent calcium sensitivity of contraction in cardiac muscle. The Journal of Physiology. 591: 475-90. PMID 23129792 DOI: 10.1113/Jphysiol.2012.241604  0.489
2013 Muthu P, Huang W, Kazmierczak K, Liang J, Rojas AI, Irving T, Szczesna-Cordary D. Structural Defects Induced by Malignant Mutations in the Regulatory Light Chain of Myosin Biophysical Journal. 104: 157a. DOI: 10.1016/J.Bpj.2012.11.887  0.402
2013 Daniel TL, George NT, Williams CD, Irving TC. In Vivo Time Resolved X-Ray Diffraction Reveals Radial Motions of Myofilaments in Insect Flight Muscle Biophysical Journal. 104: 485a-486a. DOI: 10.1016/J.Bpj.2012.11.2678  0.512
2013 Perz-Edwards RJ, Irving TC, Reedy MK. Full Tropomyosin Movement during Stretch Activation Requires Strong Binding Crossbridges Biophysical Journal. 104. DOI: 10.1016/J.Bpj.2012.11.243  0.429
2013 Mijailovich SM, Stojanovic B, Nedic D, Svicevic M, Gilbert RJ, Geeves MA, Irving T. Modulation of Crossbridge Cycling Kinetics and Length Dependent Calcium Sensitivity by Titin and Nebulin Biophysical Journal. 104: 310a. DOI: 10.1016/J.Bpj.2012.11.1723  0.505
2012 Oshima K, Sugimoto Y, Irving TC, Wakabayashi K. Head-Head Interactions of Resting Myosin Crossbridges in Intact Frog Skeletal Muscles, Revealed by Synchrotron X-Ray Fiber Diffraction Plos One. 7. PMID 23285033 DOI: 10.1371/Journal.Pone.0052421  0.48
2012 Tanner BC, Farman GP, Irving TC, Maughan DW, Palmer BM, Miller MS. Thick-to-thin filament surface distance modulates cross-bridge kinetics in Drosophila flight muscle. Biophysical Journal. 103: 1275-84. PMID 22995500 DOI: 10.1016/J.Bpj.2012.08.014  0.755
2012 Colson BA, Patel JR, Chen PP, Bekyarova T, Abdalla MI, Tong CW, Fitzsimons DP, Irving TC, Moss RL. Myosin binding protein-C phosphorylation is the principal mediator of protein kinase A effects on thick filament structure in myocardium. Journal of Molecular and Cellular Cardiology. 53: 609-16. PMID 22850286 DOI: 10.1016/J.Yjmcc.2012.07.012  0.797
2012 Ottenheijm CA, Voermans NC, Hudson BD, Irving T, Stienen GJ, van Engelen BG, Granzier H. Titin-based stiffening of muscle fibers in Ehlers-Danlos Syndrome. Journal of Applied Physiology (Bethesda, Md. : 1985). 112: 1157-65. PMID 22223454 DOI: 10.1152/Japplphysiol.01166.2011  0.452
2012 Kumar M, Schemmel P, Yuan C, Irving TC. Length Dependent Activation in Synchronous Flight Muscle from Manduca Sexta Biophysical Journal. 102. DOI: 10.1016/J.Bpj.2011.11.809  0.478
2012 Mijailovich SM, Stojanovic B, Gilbert RJ, Irving T. Mechanoregulation of Delayed Stretch Activation Biophysical Journal. 102. DOI: 10.1016/J.Bpj.2011.11.1948  0.465
2012 Hsu H, Mou YA, Irving TC, Tombe PPd. Structural Changes in Both the Troponin Complex and the Thick Filament May Underlie Myofilament Length Dependent Activation Biophysical Journal. 102. DOI: 10.1016/J.Bpj.2011.11.116  0.504
2011 Palmer BM, Sadayappan S, Wang Y, Weith AE, Previs MJ, Bekyarova T, Irving TC, Robbins J, Maughan DW. Roles for cardiac MyBP-C in maintaining myofilament lattice rigidity and prolonging myosin cross-bridge lifetime. Biophysical Journal. 101: 1661-9. PMID 21961592 DOI: 10.1016/J.Bpj.2011.08.047  0.764
2011 Muthu P, Wang L, Yuan CC, Kazmierczak K, Huang W, Hernandez OM, Kawai M, Irving TC, Szczesna-Cordary D. Structural and functional aspects of the myosin essential light chain in cardiac muscle contraction. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 25: 4394-405. PMID 21885653 DOI: 10.1096/Fj.11-191973  0.484
2011 Landahl EC, Antipova O, Bongaarts A, Barrea R, Berry R, Binder LI, Irving T, Orgel J, Vana L, Rice SE. X-ray diffraction from intact tau aggregates in human brain tissue. Nuclear Instruments & Methods in Physics Research. Section a, Accelerators, Spectrometers, Detectors and Associated Equipment. 649: 184-187. PMID 21876609 DOI: 10.1016/J.Nima.2011.01.059  0.348
2011 Tanner BC, Miller MS, Miller BM, Lekkas P, Irving TC, Maughan DW, Vigoreaux JO. COOH-terminal truncation of flightin decreases myofilament lattice organization, cross-bridge binding, and power output in Drosophila indirect flight muscle. American Journal of Physiology. Cell Physiology. 301: C383-91. PMID 21593450 DOI: 10.1152/Ajpcell.00016.2011  0.427
2011 Miller MS, Farman GP, Braddock JM, Soto-Adames FN, Irving TC, Vigoreaux JO, Maughan DW. Regulatory light chain phosphorylation and N-terminal extension increase cross-bridge binding and power output in Drosophila at in vivo myofilament lattice spacing. Biophysical Journal. 100: 1737-46. PMID 21463587 DOI: 10.1016/J.Bpj.2011.02.028  0.717
2011 Farman GP, Gore D, Allen E, Schoenfelt K, Irving TC, de Tombe PP. Myosin head orientation: a structural determinant for the Frank-Starling relationship. American Journal of Physiology. Heart and Circulatory Physiology. 300: H2155-60. PMID 21460195 DOI: 10.1152/Ajpheart.01221.2010  0.745
2011 Kathuria SV, Guo L, Graceffa R, Barrea R, Nobrega RP, Matthews CR, Irving TC, Bilsel O. Minireview: structural insights into early folding events using continuous-flow time-resolved small-angle X-ray scattering. Biopolymers. 95: 550-8. PMID 21442608 DOI: 10.1002/Bip.21628  0.318
2011 Irving T, Wu Y, Bekyarova T, Farman GP, Fukuda N, Granzier H. Thick-filament strain and interfilament spacing in passive muscle: effect of titin-based passive tension. Biophysical Journal. 100: 1499-508. PMID 21402032 DOI: 10.1016/J.Bpj.2011.01.059  0.807
2011 Perz-Edwards RJ, Irving TC, Baumann BA, Gore D, Hutchinson DC, Kržič U, Porter RL, Ward AB, Reedy MK. X-ray diffraction evidence for myosin-troponin connections and tropomyosin movement during stretch activation of insect flight muscle. Proceedings of the National Academy of Sciences of the United States of America. 108: 120-5. PMID 21148419 DOI: 10.1073/Pnas.1014599107  0.531
2011 Mijailovich SM, Stojanovic B, Irving T. Multiscale Model Predictions of X-Ray Diffraction Patterns in Contracting Skeletal Muscle Biophysical Journal. 100: 5-5. DOI: 10.1016/J.Bpj.2010.12.3378  0.478
2011 Farman GP, Hsu H, Gore D, Allen EJ, Schoenfelt KQ, Mou YA, Irving TC, de Tombe PP. Radial Motion of Myosin Heads in Isolated Intact Rat Myocardium in Diastole Biophysical Journal. 100: 584a. DOI: 10.1016/J.Bpj.2010.12.3373  0.738
2011 Elmer M, Asta C, Butler K, Dhar A, Gruebele M, Guo L, Irving T, Marcus J, Rice S, Landahl E. SAXS Study of Cytochrome-C Cold Denaturation Biophysical Journal. 100: 542a. DOI: 10.1016/J.Bpj.2010.12.3161  0.324
2011 Tanner BC, Farman GP, Irving TC, Maughan DW, Miller MS. Frequency of Maximal Power Output at in vivo Myofilament Lattice Spacing Matches Drosophila Wing Beat Frequency Biophysical Journal. 100: 12a. DOI: 10.1016/J.Bpj.2010.12.275  0.722
2011 Lee E, Gotthardt M, Nedrud J, Hudson B, Schemmel P, Hsu H, Irving T, Granzier H. Length Dependence of Activation (LDA) Studies in Mice Deficient in the N2B Element of Titin Biophysical Journal. 100. DOI: 10.1016/J.Bpj.2010.12.2678  0.427
2011 Martyn DA, Korte S, Razumova M, Feest E, Irving T, Regnier M. Both PKA Treatment and Cardiac Troponin-I N-Terminal Phosphorylation Alone Decrease Ca-Sensitivity and Eliminate Length-Dependent Activation in Skinned Cardiac Muscle Biophysical Journal. 100: 453a. DOI: 10.1016/J.Bpj.2010.12.2668  0.425
2010 Roh JH, Guo L, Kilburn JD, Briber RM, Irving T, Woodson SA. Multistage collapse of a bacterial ribozyme observed by time-resolved small-angle X-ray scattering. Journal of the American Chemical Society. 132: 10148-54. PMID 20597502 DOI: 10.1021/Ja103867P  0.3
2010 Colson BA, Locher MR, Bekyarova T, Patel JR, Fitzsimons DP, Irving TC, Moss RL. Differential roles of regulatory light chain and myosin binding protein-C phosphorylations in the modulation of cardiac force development. The Journal of Physiology. 588: 981-93. PMID 20123786 DOI: 10.1113/Jphysiol.2009.183897  0.81
2010 de Tombe PP, Mateja RD, Tachampa K, Ait Mou Y, Farman GP, Irving TC. Myofilament length dependent activation. Journal of Molecular and Cellular Cardiology. 48: 851-8. PMID 20053351 DOI: 10.1016/J.Yjmcc.2009.12.017  0.708
2010 George NT, Liu J, Simons L, Daniel TL, Irving TC. Structural and Functional Gradients with Temperature in the Flight Muscle of Manduca Sexta Biophysical Journal. 98: 348a-349a. DOI: 10.1016/J.Bpj.2009.12.1886  0.496
2010 Colson BA, Schemmel PP, Chen PP, Bekyarova T, Fitzsimons DP, Irving TC, Moss RL. Phosphorylation of Myosin Binding Protein-C Alters the Proximity of Cross-Bridges to Actin and Accelerates Myocardial Twitch Kinetics Biophysical Journal. 98. DOI: 10.1016/J.Bpj.2009.12.1877  0.818
2009 Paunesku T, Vogt S, Irving TC, Lai B, Barrea RA, Maser J, Woloschak GE. Biological applications of X-ray microprobes. International Journal of Radiation Biology. 85: 710-3. PMID 19637082 DOI: 10.1080/09553000903009514  0.312
2009 Farman GP, Miller MS, Reedy MC, Soto-Adames FN, Vigoreaux JO, Maughan DW, Irving TC. Phosphorylation and the N-terminal extension of the regulatory light chain help orient and align the myosin heads in Drosophila flight muscle. Journal of Structural Biology. 168: 240-9. PMID 19635572 DOI: 10.1016/J.Jsb.2009.07.020  0.747
2009 Miller MS, Dambacher CM, Knowles AF, Braddock JM, Farman GP, Irving TC, Swank DM, Bernstein SI, Maughan DW. Alternative S2 hinge regions of the myosin rod affect myofibrillar structure and myosin kinetics. Biophysical Journal. 96: 4132-43. PMID 19450484 DOI: 10.1016/J.Bpj.2009.02.034  0.745
2009 Barrea RA, Huang R, Cornaby S, Bilderback DH, Irving TC. High-flux hard X-ray microbeam using a single-bounce capillary with doubly focused undulator beam. Journal of Synchrotron Radiation. 16: 76-82. PMID 19096178 DOI: 10.1107/S0909049508039782  0.305
2009 Rebowski G, Boczkowska M, Hayes DB, Guo L, Irving TC, Dominguez R. Structure of an Actin Trimer Stabilized by a Tandem W Domain Hybrid Construct Biophysical Journal. 96: 1-5. DOI: 10.1016/J.Bpj.2008.12.560  0.369
2009 Farman GP, Allen EJ, Schoenfelt KQ, Gore D, Backx PH, Irving TC, de Pieter Tombe P. Changes in Thick Filament Structure of Isolated Intact Rat Cardiac Muscle During Contraction Determined by 2-D X-ray Diffraction Analysis Biophysical Journal. 96: 619a. DOI: 10.1016/J.Bpj.2008.12.3273  0.75
2009 Fusi L, Brunello E, Linari M, Reconditi M, Irving T, Gore D, Piazzesi G, Irving M, Lombardi V. Load Dependence of Structural Changes in the Myosin Filament during Muscle Activation Biophysical Journal. 96. DOI: 10.1016/J.Bpj.2008.12.3265  0.45
2009 Perz-Edwards RJ, Hutchinson DC, Prince KM, Baumann BAJ, Ward A, Bekyarova TI, Reedy MC, Gore D, Irving TC, Reedy MK. X-Ray Diffraction “Movie” Of Complete Oscillatory Work Cycles Myogenically Produced In Glycerinated Insect Flight Muscle (IFM) Biophysical Journal. 96: 2-2. DOI: 10.1016/J.Bpj.2008.12.1872  0.806
2009 Colson BA, Bekyarova T, Locher MR, Tong CW, Fitzsimons DP, Powers PA, Irving TC, Moss R. Constitutive Phosphorylation of Cardiac Myosin Binding Protein-C Increases the Probability of Myosin Cross-bridge Interaction with Actin Biophysical Journal. 96: 232a. DOI: 10.1016/J.Bpj.2008.12.1142  0.797
2008 Rebowski G, Boczkowska M, Hayes DB, Guo L, Irving TC, Dominguez R. X-ray scattering study of actin polymerization nuclei assembled by tandem W domains. Proceedings of the National Academy of Sciences of the United States of America. 105: 10785-90. PMID 18669664 DOI: 10.1073/Pnas.0801650105  0.372
2008 Bekyarova TI, Reedy MC, Baumann BAJ, Tregear RT, Ward A, Krzic U, Prince KM, Perz-Edwards RJ, Reconditi M, Gore D, Irving TC, Reedy MK. Reverse actin sliding triggers strong myosin binding that moves tropomyosin Proceedings of the National Academy of Sciences of the United States of America. 105: 10372-10377. PMID 18658238 DOI: 10.1073/Pnas.0709877105  0.813
2008 Colson BA, Bekyarova T, Locher MR, Fitzsimons DP, Irving TC, Moss RL. Protein kinase A-mediated phosphorylation of cMyBP-C increases proximity of myosin heads to actin in resting myocardium. Circulation Research. 103: 244-51. PMID 18599866 DOI: 10.1161/Circresaha.108.178996  0.805
2008 Miller MS, Lekkas P, Braddock JM, Farman GP, Ballif BA, Irving TC, Maughan DW, Vigoreaux JO. Aging enhances indirect flight muscle fiber performance yet decreases flight ability in Drosophila. Biophysical Journal. 95: 2391-401. PMID 18515368 DOI: 10.1529/Biophysj.108.130005  0.729
2007 Piazzesi G, Reconditi M, Linari M, Lucii L, Bianco P, Brunello E, Decostre V, Stewart A, Gore DB, Irving TC, Irving M, Lombardi V. Skeletal muscle performance determined by modulation of number of myosin motors rather than motor force or stroke size. Cell. 131: 784-95. PMID 18022371 DOI: 10.1016/j.cell.2007.09.045  0.313
2007 Granzier H, Radke M, Royal J, Wu Y, Irving TC, Gotthardt M, Labeit S. Functional genomics of chicken, mouse, and human titin supports splice diversity as an important mechanism for regulating biomechanics of striated muscle. American Journal of Physiology. Regulatory, Integrative and Comparative Physiology. 293: R557-67. PMID 17522126 DOI: 10.1152/Ajpregu.00001.2007  0.388
2007 Farman GP, Allen EJ, Gore D, Irving TC, de Tombe PP. Interfilament spacing is preserved during sarcomere length isometric contractions in rat cardiac trabeculae. Biophysical Journal. 92: L73-5. PMID 17293398 DOI: 10.1529/Biophysj.107.104257  0.735
2007 Colson BA, Bekyarova T, Fitzsimons DP, Irving TC, Moss RL. Radial displacement of myosin cross-bridges in mouse myocardium due to ablation of myosin binding protein-C. Journal of Molecular Biology. 367: 36-41. PMID 17254601 DOI: 10.1016/J.Jmb.2006.12.063  0.812
2007 Oshima K, Takezawa Y, Sugimoto Y, Kobayashi T, Irving TC, Wakabayashi K. Axial dispositions and conformations of myosin crossbridges along thick filaments in relaxed and contracting states of vertebrate striated muscles by X-ray fiber diffraction. Journal of Molecular Biology. 367: 275-301. PMID 17239393 DOI: 10.1016/J.Jmb.2006.12.036  0.444
2007 Oshima K, Takezawa Y, Sugimoto Y, Irving TC, Wakabayashi K. 1P157 Dispositional and Conformafonal Changes of Myosin Crossbridges in Skeletal Musde Contraction and Regulation by X-ray Fiber Diffraction(Muscle-muscle proteins and contraction,Poster Presentations) Seibutsu Butsuri. 47. DOI: 10.2142/Biophys.47.S62_4  0.466
2006 Squire JM, Bekyarova T, Farman G, Gore D, Rajkumar G, Knupp C, Lucaveche C, Reedy MC, Reedy MK, Irving TC. The myosin filament superlattice in the flight muscles of flies: A-band lattice optimisation for stretch-activation? Journal of Molecular Biology. 361: 823-38. PMID 16887144 DOI: 10.1016/J.Jmb.2006.06.072  0.792
2006 Farman GP, Walker JS, de Tombe PP, Irving TC. Impact of osmotic compression on sarcomere structure and myofilament calcium sensitivity of isolated rat myocardium. American Journal of Physiology. Heart and Circulatory Physiology. 291: H1847-55. PMID 16751283 DOI: 10.1152/Ajpheart.01237.2005  0.722
2005 Squire JM, Knupp C, Roessle M, Al-Khayat HA, Irving TC, Eakins F, Mok NS, Harford JJ, Reedy MK. X-ray diffraction studies of striated muscles. Advances in Experimental Medicine and Biology. 565: 45-60; discussion 35. PMID 16106966 DOI: 10.1007/0-387-24990-7_5  0.479
2005 Miller MS, Palmer BM, Ruch S, Martin LA, Farman GP, Wang Y, Robbins J, Irving TC, Maughan DW. The essential light chain N-terminal extension alters force and fiber kinetics in mouse cardiac muscle. The Journal of Biological Chemistry. 280: 34427-34. PMID 16085933 DOI: 10.1074/Jbc.M508430200  0.745
2005 Fukuda N, Wu Y, Farman G, Irving TC, Granzier H. Titin-based modulation of active tension and interfilament lattice spacing in skinned rat cardiac muscle. PflüGers Archiv : European Journal of Physiology. 449: 449-57. PMID 15688246 DOI: 10.1007/S00424-004-1354-6  0.74
2005 Dickinson M, Farman G, Frye M, Bekyarova T, Gore D, Maughan D, Irving T. Molecular dynamics of cyclically contracting insect flight muscle in vivo Nature. 433: 330-333. PMID 15662427 DOI: 10.1038/Nature03230  0.798
2005 Barrea RA, Fischetti R, Stepanov S, Rosenbaum G, Kondrashkina E, Bunker GB, Black E, Zhang K, Gore D, Heurich R, Vukonich M, Karanfil C, Kropf AJ, Wang S, Irving TC. Biological XAFS at the BioCAT undulator beamline 18ID at the APS Physica Scripta T. 867-869. DOI: 10.1238/Physica.Topical.115A00867  0.302
2004 Palmer BM, McConnell BK, Li GH, Seidman CE, Seidman JG, Irving TC, Alpert NR, Maughan DW. Reduced cross-bridge dependent stiffness of skinned myocardium from mice lacking cardiac myosin binding protein-C. Molecular and Cellular Biochemistry. 263: 73-80. PMID 27520666 DOI: 10.1023/B:Mcbi.0000041849.60591.45  0.386
2004 Liu J, Reedy MC, Goldman YE, Franzini-Armstrong C, Sasaki H, Tregear RT, Lucaveche C, Winkler H, Baumann BA, Squire JM, Irving TC, Reedy MK, Taylor KA. Electron tomography of fast frozen, stretched rigor fibers reveals elastic distortions in the myosin crossbridges. Journal of Structural Biology. 147: 268-82. PMID 15450296 DOI: 10.1016/J.Jsb.2004.03.008  0.416
2004 Oshima K, Takezawa Y, Sugimoto Y, Irving TC, Wakabayashi K. 1P182 Modeling X-ray analysis of a perturbed structure of the myosin filament and crossbridge disposition in the relaxed and contracting states Seibutsu Butsuri. 44. DOI: 10.2142/Biophys.44.S75_2  0.39
2004 Sugimoto Y, Kondrashkina E, Arata T, Aihara T, Takezawa Y, Irving TC, Wakabayashi K. 1P175 Conformational changes of smooth muscle heavy mero myosin, studied by X-ray solution scattering Seibutsu Butsuri. 44. DOI: 10.2142/Biophys.44.S73_3  0.42
2003 Squire JM, AL-Khayat HA, Harford JJ, Hudson L, Irving TC, Knupp C, Mok NS, Reedy MK. Myosin filament structure and myosin crossbridge dynamics in fish and insect muscles. Advances in Experimental Medicine and Biology. 538: 251-66; discussion 2. PMID 15098673  0.327
2003 Fukuda N, Wu Y, Farman G, Irving TC, Granzier H. Titin isoform variance and length dependence of activation in skinned bovine cardiac muscle. The Journal of Physiology. 553: 147-54. PMID 12963792 DOI: 10.1113/Jphysiol.2003.049759  0.751
2003 Fischetti RF, Rodi DJ, Mirza A, Irving TC, Kondrashkina E, Makowski L. High-resolution wide-angle X-ray scattering of protein solutions: effect of beam dose on protein integrity. Journal of Synchrotron Radiation. 10: 398-404. PMID 12944630 DOI: 10.1107/S0909049503016583  0.325
2003 AL-Khayat HA, Hudson L, Reedy MK, Irving TC, Squire JM. Myosin head configuration in relaxed insect flight muscle: x-ray modeled resting cross-bridges in a pre-powerstroke state are poised for actin binding. Biophysical Journal. 85: 1063-79. PMID 12885653 DOI: 10.1016/S0006-3495(03)74545-7  0.456
2003 Konhilas JP, Irving TC, Wolska BM, Jweied EE, Martin AF, Solaro RJ, de Tombe PP. Troponin I in the murine myocardium: influence on length-dependent activation and interfilament spacing. The Journal of Physiology. 547: 951-61. PMID 12562915 DOI: 10.1113/Jphysiol.2002.038117  0.333
2002 Konhilas JP, Irving TC, de Tombe PP. Length-dependent activation in three striated muscle types of the rat. The Journal of Physiology. 544: 225-36. PMID 12356894 DOI: 10.1113/jphysiol.2002.024505  0.374
2002 Pieples K, Arteaga G, Solaro RJ, Grupp I, Lorenz JN, Boivin GP, Jagatheesan G, Labitzke E, DeTombe PP, Konhilas JP, Irving TC, Wieczorek DF. Tropomyosin 3 expression leads to hypercontractility and attenuates myofilament length-dependent Ca(2+) activation. American Journal of Physiology. Heart and Circulatory Physiology. 283: H1344-53. PMID 12234784 DOI: 10.1152/Ajpheart.00351.2002  0.417
2001 Irving T, Bhattacharya S, Tesic I, Moore J, Farman G, Simcox A, Vigoreaux J, Maughan D. Changes in myofibrillar structure and function produced by N-terminal deletion of the regulatory light chain in Drosophila. Journal of Muscle Research and Cell Motility. 22: 675-83. PMID 12222828 DOI: 10.1023/A:1016336024366  0.742
2001 Cazorla O, Wu Y, Irving TC, Granzier H. Titin-based modulation of calcium sensitivity of active tension in mouse skinned cardiac myocytes Circulation Research. 88: 1028-1035. PMID 11375272 DOI: 10.1161/Hh1001.090876  0.356
2000 Irving TC, Konhilas J, Perry D, Fischetti R, De Tombe PP. Myofilament lattice spacing as a function of sarcomere length in isolated rat myocardium American Journal of Physiology - Heart and Circulatory Physiology. 279. PMID 11045995  0.351
2000 Irving TC, Maughan DW. In vivo x-ray diffraction of indirect flight muscle from Drosophila melanogaster Biophysical Journal. 78: 2511-2515. PMID 10777748  0.432
2000 Irving TC, Fischetti RF. Fibre Diffraction Using the BioCAT Facility at the Advanced Photon Source Fibre Diffraction Review. 9: 58. DOI: 10.1382/S20000958  0.336
2000 Irving TC, Fischetti R, Rosenbaum G, Bunker GB. Fiber diffraction using the BioCAT undulator beamline at the Advanced Photon Source Nuclear Instruments and Methods in Physics Research, Section a: Accelerators, Spectrometers, Detectors and Associated Equipment. 448: 250-254. DOI: 10.1016/S0168-9002(99)00732-9  0.306
1998 Irving TC, Li Q, Williams BA, Millman BM. Z/I and A-band lattice spacings in frog skeletal muscle: Effects of contraction and osmolarity Journal of Muscle Research and Cell Motility. 19: 811-823. PMID 9836152 DOI: 10.1023/A:1005459605964  0.381
1998 Tregear RT, Edwards RJ, Irving TC, Poole KJ, Reedy MC, Schmitz H, Towns-Andrews E, Reedy MK. X-ray diffraction indicates that active cross-bridges bind to actin target zones in insect flight muscle. Biophysical Journal. 74: 1439-51. PMID 9512040 DOI: 10.1016/S0006-3495(98)77856-7  0.326
1998 Wakabayashi K, Sugiyama H, Yagi N, Irving TC, Iwamoto H, Horiuti K, Takezawa Y, Sugimoto Y, Ogino M, Iino S, Kim DS, Majima T, Amemiya Y, Yamamoto S, Ando M. High-resolution X-ray diffraction of muscle using undulator radiation from the Tristan main ring at KEK Journal of Synchrotron Radiation. 5: 280-285. DOI: 10.1107/S0909049597013861  0.422
1998 Tsuruta H, Brennan S, Rek ZU, Irving TC, Tompkins WH, Hodgson KO. A Wide-Bandpass Multilayer Monochromator for Biological Small-Angle Scattering and Fiber Diffraction Studies Journal of Applied Crystallography. 31: 672-682. DOI: 10.1107/S0021889898002702  0.327
1996 Yagi N, Wakabayashi K, Iwamoto H, Horiuti K, Kojima I, Irving TC, Takezawa Y, Sugimoto Y, Iwamoto S, Majima T, Amemiya Y, Ando M. Small-angle X-ray diffraction of muscle using undulator radiation from the tristan main ring at KEK Journal of Synchrotron Radiation. 3: 305-312. DOI: 10.1107/S0909049596008928  0.505
1996 Tsuruta H, Irving TC, Tompkins HW, Rek ZU, Brennan S, Hodgson KO. Wide-bandpass 'multilayer' monochromator for small-angle X-ray scattering and fiber diffraction studies on biological systems Acta Crystallographica Section a Foundations of Crystallography. 52: C484-C484. DOI: 10.1107/S0108767396080142  0.32
1995 Granzier HL, Irving TC. Passive tension in cardiac muscle: Contribution of collagen, titin, microtubules, and intermediate filaments Biophysical Journal. 68: 1027-1044. PMID 7756523  0.354
1989 Irving TC, Millman BM. Changes in thick filament structure during compression of the filament lattice in relaxed frog sartorius muscle Journal of Muscle Research and Cell Motility. 10: 385-394. PMID 2480365 DOI: 10.1007/BF01758435  0.324
1988 Millman BM, Irving TC. Filament lattice of frog striated muscle. Radial forces, lattice stability, and filament compression in the A-band of relaxed and rigor muscle Biophysical Journal. 54: 437-447. PMID 3264728 DOI: 10.1016/S0006-3495(88)82977-1  0.341
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