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Alexander L. Ruchelman, Ph.D. - Publications

Affiliations: 
2002 Rutgers University, New Brunswick, New Brunswick, NJ, United States 
Area:
Pharmaceutical Chemistry, Organic Chemistry, Oncology
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14 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2011 Ruchelman AL, Man HW, Chen R, Liu W, Lu L, Cedzik D, Zhang L, Leisten J, Collette A, Narla RK, Raymon HK, Muller GW. 1,1-Diarylalkenes as anticancer agents: dual inhibitors of tubulin polymerization and phosphodiesterase 4. Bioorganic & Medicinal Chemistry. 19: 6356-74. PMID 21955454 DOI: 10.1016/j.bmc.2011.08.068  0.301
2006 Zhu S, Ruchelman AL, Zhou N, Liu A, Liu LF, LaVoie EJ. 6-Substituted 6H-dibenzo[c,h][2,6]naphthyridin-5-ones: reversed lactam analogues of ARC-111 with potent topoisomerase I-targeting activity and cytotoxicity. Bioorganic & Medicinal Chemistry. 14: 3131-43. PMID 16412652 DOI: 10.1016/J.Bmc.2005.12.028  0.701
2005 Zhu S, Ruchelman AL, Zhou N, Liu AA, Liu LF, LaVoie EJ. Esters and amides of 2,3-dimethoxy-8,9-methylenedioxy-benzo[i]phenanthridine-12-carboxylic acid: potent cytotoxic and topoisomerase I-targeting agents. Bioorganic & Medicinal Chemistry. 13: 6782-94. PMID 16153852 DOI: 10.1016/J.Bmc.2005.07.033  0.668
2005 Ruchelman AL, Houghton PJ, Zhou N, Liu A, Liu LF, LaVoie EJ. 5-(2-aminoethyl)dibenzo[c,h][1,6]naphthyridin-6-ones: variation of n-alkyl substituents modulates sensitivity to efflux transporters associated with multidrug resistance. Journal of Medicinal Chemistry. 48: 792-804. PMID 15689163 DOI: 10.1021/Jm049447Z  0.64
2004 Ruchelman AL, Zhu S, Zhou N, Liu A, Liu LF, LaVoie EJ. Dimethoxybenzo[i]phenanthridine-12-carboxylic acid derivatives and 6H-dibenzo[c,h][2,6]naphthyridin-5-ones with potent topoisomerase I-targeting activity and cytotoxicity. Bioorganic & Medicinal Chemistry Letters. 14: 5585-9. PMID 15482929 DOI: 10.1016/J.Bmcl.2004.08.070  0.716
2004 Ruchelman AL, Kerrigan JE, Li TK, Zhou N, Liu A, Liu LF, LaVoie EJ. Nitro and amino substitution within the A-ring of 5H-8,9-dimethoxy-5-(2-N,N-dimethylaminoethyl)dibenzo[c,h][1,6]naphthyridin-6-ones: influence on topoisomerase I-targeting activity and cytotoxicity. Bioorganic & Medicinal Chemistry. 12: 3731-42. PMID 15186859 DOI: 10.1016/J.Bmc.2004.03.076  0.731
2004 Ruchelman AL, Singh SK, Ray A, Wu X, Yang JM, Zhou N, Liu A, Liu LF, LaVoie EJ. 11H-Isoquino[4,3-c]cinnolin-12-ones; novel anticancer agents with potent topoisomerase I-targeting activity and cytotoxicity. Bioorganic & Medicinal Chemistry. 12: 795-806. PMID 14759740 DOI: 10.1016/J.Bmc.2003.10.061  0.722
2004 Ruchelman A, Singh S, Liu A, Zhou N, Liu L, La Voie E. Cytotoxicity of 5H-Dibenzo[c,h][1,6]naphthyridin-6-ones and 6H-Indeno[1,2-c]isoquinolin-5,11-diones in Tumor Cells Sensitive and Resistant to Camptothecin Analogs Letters in Drug Design & Discovery. 1: 198-202. DOI: 10.2174/1570180043399064  0.502
2003 Li TK, Houghton PJ, Desai SD, Daroui P, Liu AA, Hars ES, Ruchelman AL, LaVoie EJ, Liu LF. Characterization of ARC-111 as a novel topoisomerase I-targeting anticancer drug. Cancer Research. 63: 8400-7. PMID 14679002  0.595
2003 Kerrigan JE, Pilch DS, Ruchelman AL, Zhou N, Liu A, Liu L, LaVoie EJ. 5H-8,9-dimethoxy-5-(2-N,N-dimethylaminoethyl)dibenzo[c,h][1,6]naphthyridin-6-ones and related compounds as TOP1-targeting agents: influence of structure on the ternary cleavable complex formation. Bioorganic & Medicinal Chemistry Letters. 13: 3395-9. PMID 14505635 DOI: 10.1016/S0960-894X(03)00797-2  0.584
2003 Singh SK, Ruchelman AL, Li TK, Liu A, Liu LF, LaVoie EJ. Nitro and amino substitution in the D-ring of 5-(2-dimethylaminoethyl)- 2,3-methylenedioxy-5H-dibenzo[c,h][1,6]naphthyridin-6-ones: effect on topoisomerase-I targeting activity and cytotoxicity. Journal of Medicinal Chemistry. 46: 2254-7. PMID 12747798 DOI: 10.1021/Jm020498A  0.725
2003 Ruchelman AL, Singh SK, Ray A, Wu XH, Yang JM, Li TK, Liu A, Liu LF, LaVoie EJ. 5H-Dibenzo[c,h]1,6-naphthyridin-6-ones: novel topoisomerase I-targeting anticancer agents with potent cytotoxic activity. Bioorganic & Medicinal Chemistry. 11: 2061-73. PMID 12670657 DOI: 10.1016/S0968-0896(03)00051-8  0.719
2003 Singh SK, Ruchelman AL, Zhou N, Li TK, Liu A, Liu LF, LaVoie EJ. Aza-analogs of dibenzo[c,h]cinnoline: Triazachrysenes as potent topoisomerase I-targeting anticancer agents Medicinal Chemistry Research. 12: 1-12.  0.698
2002 Ruchelman AL, Singh SK, Wu X, Ray A, Yang JM, Li TK, Liu A, Liu LF, LaVoie EJ. Diaza- and triazachrysenes: potent topoisomerase-targeting agents with exceptional antitumor activity against the human tumor xenograft, MDA-MB-435. Bioorganic & Medicinal Chemistry Letters. 12: 3333-6. PMID 12392745 DOI: 10.1016/S0960-894X(02)00737-0  0.638
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