Aaron DiAntonio - Publications

Affiliations: 
Washington University, Saint Louis, St. Louis, MO 
Area:
Drosophila NMJ

138 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2024 Dingwall CB, Sasaki Y, Strickland A, Summers DW, Bloom AJ, DiAntonio A, Milbrandt J. Suppressing phagocyte activation by overexpressing the phosphatidylserine lipase ABHD12 preserves sarmopathic nerves. Biorxiv : the Preprint Server For Biology. PMID 38979309 DOI: 10.1101/2024.06.20.599919  0.59
2024 DeVault L, Mateusiak C, Palucki J, Brent M, Milbrandt J, DiAntonio A. The response of Dual-leucine zipper kinase (DLK) to nocodazole: Evidence for a homeostatic cytoskeletal repair mechanism. Plos One. 19: e0300539. PMID 38574058 DOI: 10.1371/journal.pone.0300539  0.546
2024 Krus KL, Benitez AM, Strickland A, Milbrandt J, Bloom AJ, DiAntonio A. Reduced STMN2 and pathogenic TDP-43, two hallmarks of ALS, synergize to accelerate motor decline in mice. Biorxiv : the Preprint Server For Biology. PMID 38562780 DOI: 10.1101/2024.03.19.585052  0.49
2024 Guo Y, Mehrabian Z, Milbrandt J, DiAntonio A, Bernstein SL. Synergistic Protection of Retinal Ganglion Cells (RGCs) by SARM1 Inactivation with CNTF in a Rodent Model of Nonarteritic Anterior Ischemic Optic Neuropathy. Cells. 13. PMID 38334594 DOI: 10.3390/cells13030202  0.453
2024 Brazill JM, Shen IR, Craft CS, Magee KL, Park JS, Lorenz M, Strickland A, Wee NK, Zhang X, Beeve AT, Meyer GA, Milbrandt J, DiAntonio A, Scheller EL. Sarm1 knockout prevents type 1 diabetic bone disease in females independent of neuropathy. Jci Insight. PMID 38175722 DOI: 10.1172/jci.insight.175159  0.406
2023 DeVault L, Mateusiak C, Palucki J, Brent M, Milbrandt J, DiAntonio A. The response of Dual-Leucine Zipper Kinase (DLK) to nocodazole: evidence for a homeostatic cytoskeletal repair mechanism. Biorxiv : the Preprint Server For Biology. PMID 37873434 DOI: 10.1101/2023.10.06.561227  0.541
2023 Klontz E, Obi JO, Wang Y, Glendening G, Carr J, Tsibouris C, Buddula S, Nallar S, Soares AS, Beckett D, Redzic JS, Eisenmesser E, Palm C, Schmidt K, Scudder AH, ... ... Diantonio A, et al. The structure of NAD consuming protein Acinetobacter baumannii TIR domain shows unique kinetics and conformations. The Journal of Biological Chemistry. 105290. PMID 37758001 DOI: 10.1016/j.jbc.2023.105290  0.451
2022 Dingwall CB, Strickland A, Yum SW, Yim AK, Zhu J, Wang PL, Yamada Y, Schmidt RE, Sasaki Y, Bloom AJ, DiAntonio A, Milbrandt J. Macrophage depletion blocks congenital SARM1-dependent neuropathy. The Journal of Clinical Investigation. PMID 36287209 DOI: 10.1172/JCI159800  0.547
2022 Yamada Y, Strickland A, Sasaki Y, Bloom AJ, DiAntonio A, Milbrandt J. A SARM1/mitochondrial feedback loop drives neuropathogenesis in a Charcot-Marie-Tooth disease type 2A rat model. The Journal of Clinical Investigation. PMID 36287202 DOI: 10.1172/JCI161566  0.545
2022 Manik MK, Shi Y, Li S, Zaydman MA, Damaraju N, Eastman S, Smith TG, Gu W, Masic V, Mosaiab T, Weagley JS, Hancock SJ, Vasquez E, Hartley-Tassell L, Kargios N, ... ... DiAntonio A, et al. Cyclic ADP ribose isomers: Production, chemical structures, and immune signaling. Science (New York, N.Y.). eadc8969. PMID 36048923 DOI: 10.1126/science.adc8969  0.422
2022 Zaydman MA, Little AA, Haro F, Aksianiuk V, Buchser WJ, DiAntonio A, Gordon JI, Milbrandt J, Raman AS. Defining hierarchical protein interaction networks from spectral analysis of bacterial proteomes. Elife. 11. PMID 35976223 DOI: 10.7554/eLife.74104  0.417
2022 Krus KL, Strickland A, Yamada Y, Devault L, Schmidt RE, Bloom AJ, Milbrandt J, DiAntonio A. Loss of Stathmin-2, a hallmark of TDP-43-associated ALS, causes motor neuropathy. Cell Reports. 39: 111001. PMID 35767949 DOI: 10.1016/j.celrep.2022.111001  0.447
2022 Brace EJ, Essuman K, Mao X, Palucki J, Sasaki Y, Milbrandt J, DiAntonio A. Distinct developmental and degenerative functions of SARM1 require NAD+ hydrolase activity. Plos Genetics. 18: e1010246. PMID 35737728 DOI: 10.1371/journal.pgen.1010246  0.771
2022 Weagley JS, Zaydman M, Venkatesh S, Sasaki Y, Damaraju N, Yenkin A, Buchser W, Rodionov DA, Osterman A, Ahmed T, Barratt MJ, DiAntonio A, Milbrandt J, Gordon JI. Products of gut microbial Toll/interleukin-1 receptor domain NADase activities in gnotobiotic mice and Bangladeshi children with malnutrition. Cell Reports. 39: 110738. PMID 35476981 DOI: 10.1016/j.celrep.2022.110738  0.412
2022 Lee B, Oh Y, Cho E, DiAntonio A, Cavalli V, Shin JE, Choi HW, Cho Y. FK506-binding protein-like and FK506-binding protein 8 regulate dual leucine zipper kinase degradation and neuronal responses to axon injury. The Journal of Biological Chemistry. 101647. PMID 35101451 DOI: 10.1016/j.jbc.2022.101647  0.568
2022 Bloom AJ, Mao X, Strickland A, Sasaki Y, Milbrandt J, DiAntonio A. Constitutively active SARM1 variants that induce neuropathy are enriched in ALS patients. Molecular Neurodegeneration. 17: 1. PMID 34991663 DOI: 10.1186/s13024-021-00511-x  0.501
2022 Li Y, Pazyra-Murphy MF, Avizonis D, de Sá Tavares Russo M, Tang S, Chen CY, Hsueh YP, Bergholz JS, Jiang T, Zhao JJ, Zhu J, Ko KW, Milbrandt J, DiAntonio A, Segal RA. Sarm1 activation produces cADPR to increase intra-axonal Ca++ and promote axon degeneration in PIPN. The Journal of Cell Biology. 221. PMID 34935867 DOI: 10.1083/jcb.202106080  0.564
2021 Ko KW, Devault L, Sasaki Y, Milbrandt J, DiAntonio A. Live imaging reveals the cellular events downstream of SARM1 activation. Elife. 10. PMID 34779400 DOI: 10.7554/eLife.71148  0.566
2021 Wu T, Zhu J, Strickland A, Ko KW, Sasaki Y, Dingwall CB, Yamada Y, Figley MD, Mao X, Neiner A, Bloom AJ, DiAntonio A, Milbrandt J. Neurotoxins subvert the allosteric activation mechanism of SARM1 to induce neuronal loss. Cell Reports. 37: 109872. PMID 34686345 DOI: 10.1016/j.celrep.2021.109872  0.823
2021 Eastman S, Smith T, Zaydman MA, Kim P, Martinez S, Damaraju N, DiAntonio A, Milbrandt J, Clemente TE, Alfano JR, Guo M. A phytobacterial TIR domain effector manipulates NAD to promote virulence. The New Phytologist. PMID 34657283 DOI: 10.1111/nph.17805  0.426
2021 DiAntonio A, Milbrandt J, Figley MD. The SARM1 TIR NADase: Mechanistic Similarities to Bacterial Phage Defense and Toxin-Antitoxin Systems. Frontiers in Immunology. 12: 752898. PMID 34630431 DOI: 10.3389/fimmu.2021.752898  0.805
2021 Sasaki Y, Zhu J, Shi Y, Gu W, Kobe B, Ve T, DiAntonio A, Milbrandt J. Nicotinic acid mononucleotide is an allosteric SARM1 inhibitor promoting axonal protection. Experimental Neurology. 113842. PMID 34403688 DOI: 10.1016/j.expneurol.2021.113842  0.54
2021 Figley MD, Gu W, Nanson JD, Shi Y, Sasaki Y, Cunnea K, Malde AK, Jia X, Luo Z, Saikot FK, Mosaiab T, Masic V, Holt S, Hartley-Tassell L, McGuinness HY, ... ... DiAntonio A, et al. SARM1 is a metabolic sensor activated by an increased NMN/NAD ratio to trigger axon degeneration. Neuron. PMID 33657413 DOI: 10.1016/j.neuron.2021.02.009  0.823
2021 Chen YH, Sasaki Y, DiAntonio A, Milbrandt J. SARM1 is required in human derived sensory neurons for injury-induced and neurotoxic axon degeneration. Experimental Neurology. 113636. PMID 33548217 DOI: 10.1016/j.expneurol.2021.113636  0.558
2021 Shen C, Vohra M, Zhang P, Mao X, Figley MD, Zhu J, Sasaki Y, Wu H, DiAntonio A, Milbrandt J. Multiple domain interfaces mediate SARM1 autoinhibition. Proceedings of the National Academy of Sciences of the United States of America. 118. PMID 33468661 DOI: 10.1073/pnas.2023151118  0.803
2021 Hughes RO, Bosanac T, Mao X, Engber TM, DiAntonio A, Milbrandt J, Devraj R, Krauss R. Small Molecule SARM1 Inhibitors Recapitulate the SARM1 Phenotype and Allow Recovery of a Metastable Pool of Axons Fated to Degenerate. Cell Reports. 34: 108588. PMID 33406435 DOI: 10.1016/j.celrep.2020.108588  0.577
2020 Sasaki Y, Kakita H, Kubota S, Sene A, Lee TJ, Ban N, Dong Z, Lin JB, Boye SL, DiAntonio A, Boye SE, Apte RS, Milbrandt J. SARM1 depletion rescues NMNAT1-dependent photoreceptor cell death and retinal degeneration. Elife. 9. PMID 33107823 DOI: 10.7554/eLife.62027  0.519
2020 Ko KW, Milbrandt J, DiAntonio A. SARM1 acts downstream of neuroinflammatory and necroptotic signaling to induce axon degeneration. The Journal of Cell Biology. 219. PMID 32609299 DOI: 10.1083/Jcb.201912047  0.633
2020 Bramley JC, Yenkin AL, Zaydman MA, DiAntonio A, Milbrandt JD, Buchser WJ. Domain-centric database to uncover structure of minimally characterized viral genomes. Scientific Data. 7: 202. PMID 32587259 DOI: 10.1038/s41597-020-0536-1  0.451
2020 Brace EJ, DiAntonio A. Models of Axon Degeneration in Drosophila Larvae. Methods in Molecular Biology (Clifton, N.J.). 2143: 311-320. PMID 32524490 DOI: 10.1007/978-1-0716-0585-1_23  0.784
2020 Figley MD, DiAntonio A. The SARM1 axon degeneration pathway: control of the NAD metabolome regulates axon survival in health and disease. Current Opinion in Neurobiology. 63: 59-66. PMID 32311648 DOI: 10.1016/j.conb.2020.02.012  0.826
2020 Sasaki Y, Engber TM, Hughes RO, Figley MD, Wu T, Bosanac T, Devraj R, Milbrandt J, Krauss R, DiAntonio A. cADPR is a gene dosage-sensitive biomarker of SARM1 activity in healthy, compromised, and degenerating axons. Experimental Neurology. 113252. PMID 32087251 DOI: 10.1016/J.Expneurol.2020.113252  0.832
2019 Summers DW, Frey E, Walker LJ, Milbrandt J, DiAntonio A. DLK Activation Synergizes with Mitochondrial Dysfunction to Downregulate Axon Survival Factors and Promote SARM1-Dependent Axon Degeneration. Molecular Neurobiology. PMID 31696428 DOI: 10.1007/S12035-019-01796-2  0.635
2019 Geisler S, Doan RA, Cheng GC, Cetinkaya-Fisgin A, Huang SX, Höke A, Milbrandt J, DiAntonio A. Vincristine and bortezomib use distinct upstream mechanisms to activate a common SARM1-dependent axon degeneration program. Jci Insight. 4. PMID 31484833 DOI: 10.1172/Jci.Insight.129920  0.619
2019 Russo A, DiAntonio A. Wnd/DLK Is a Critical Target of FMRP Responsible for Neurodevelopmental and Behavior Defects in the Drosophila Model of Fragile X Syndrome. Cell Reports. 28: 2581-2593.e5. PMID 31484070 DOI: 10.1016/j.celrep.2019.08.001  0.355
2019 Wan L, Essuman K, Anderson RG, Sasaki Y, Monteiro F, Chung EH, Osborne Nishimura E, DiAntonio A, Milbrandt J, Dangl JL, Nishimura MT. TIR domains of plant immune receptors are NAD-cleaving enzymes that promote cell death. Science (New York, N.Y.). 365: 799-803. PMID 31439793 DOI: 10.1126/Science.Aax1771  0.503
2019 DiAntonio A. Axon degeneration: mechanistic insights lead to therapeutic opportunities for the prevention and treatment of peripheral neuropathy. Pain. 160: S17-S22. PMID 31008845 DOI: 10.1097/j.pain.0000000000001528  0.342
2019 Shin JE, Ha H, Kim YK, Cho Y, DiAntonio A. DLK regulates a distinctive transcriptional regeneration program after peripheral nerve injury. Neurobiology of Disease. PMID 30735704 DOI: 10.1016/J.Nbd.2019.02.001  0.592
2019 Russo A, Goel P, Brace EJ, Buser C, Dickman D, DiAntonio A. The E3 ligase Highwire promotes synaptic transmission by targeting the NAD-synthesizing enzyme dNmnat. Embo Reports. PMID 30692130 DOI: 10.15252/embr.201846975  0.839
2019 Geisler S, Huang SX, Strickland A, Doan RA, Summers DW, Mao X, Park J, DiAntonio A, Milbrandt J. Gene therapy targeting SARM1 blocks pathological axon degeneration in mice. The Journal of Experimental Medicine. PMID 30642945 DOI: 10.1084/Jem.20181040  0.613
2018 Karney-Grobe S, Russo A, Frey E, Milbrandt J, DiAntonio A. HSP90 is a chaperone for DLK and is required for axon injury signaling. Proceedings of the National Academy of Sciences of the United States of America. PMID 30275300 DOI: 10.1073/Pnas.1805351115  0.619
2018 Summers DW, Milbrandt J, DiAntonio A. Palmitoylation enables MAPK-dependent proteostasis of axon survival factors. Proceedings of the National Academy of Sciences of the United States of America. PMID 30150401 DOI: 10.1073/Pnas.1806933115  0.639
2018 Frey E, Karney-Grobe S, Krolak T, Milbrandt J, DiAntonio A. TRPV1 Agonist, Capsaicin, Induces Axon Outgrowth after Injury via Ca/PKA Signaling. Eneuro. 5. PMID 29854941 DOI: 10.1523/ENEURO.0095-18.2018  0.357
2018 Essuman K, Summers DW, Sasaki Y, Mao X, Yim AKY, DiAntonio A, Milbrandt J. TIR Domain Proteins Are an Ancient Family of NAD+-Consuming Enzymes. Current Biology : Cb. PMID 29395922 DOI: 10.1016/J.Cub.2017.12.024  0.554
2017 Essuman K, Summers DW, Sasaki Y, Mao X, DiAntonio A, Milbrandt J. The SARM1 Toll/Interleukin-1 Receptor Domain Possesses Intrinsic NAD(+) Cleavage Activity that Promotes Pathological Axonal Degeneration. Neuron. 93: 1334-1343.e5. PMID 28334607 DOI: 10.1016/J.Neuron.2017.02.022  0.642
2017 Walker LJ, Summers DW, Sasaki Y, Brace EJ, Milbrandt J, DiAntonio A. MAPK signaling promotes axonal degeneration by speeding the turnover of the axonal maintenance factor NMNAT2. Elife. 6. PMID 28095293 DOI: 10.7554/Elife.22540  0.832
2016 Geisler S, Doan RA, Strickland A, Huang X, Milbrandt J, DiAntonio A. Prevention of vincristine-induced peripheral neuropathy by genetic deletion of SARM1 in mice. Brain : a Journal of Neurology. PMID 27797810 DOI: 10.1093/Brain/Aww251  0.611
2016 Sasaki Y, Nakagawa T, Mao X, DiAntonio A, Milbrandt J. NMNAT1 inhibits axon degeneration via blockade of SARM1-mediated NAD(+) depletion. Elife. 5. PMID 27735788 DOI: 10.7554/Elife.19749  0.625
2016 Summers DW, Gibson DA, DiAntonio A, Milbrandt J. SARM1-specific motifs in the TIR domain enable NAD+ loss and regulate injury-induced SARM1 activation. Proceedings of the National Academy of Sciences of the United States of America. PMID 27671644 DOI: 10.1073/Pnas.1601506113  0.732
2016 Hao Y, Frey E, Yoon C, Wong H, Nestorovski D, Holzman LB, Giger RJ, DiAntonio A, Collins C. An evolutionarily conserved mechanism for cAMP elicited axonal regeneration involves direct activation of the dual leucine zipper kinase DLK. Elife. 5. PMID 27268300 DOI: 10.7554/Elife.14048  0.77
2016 Bhattacharya MR, Geisler S, Pittman SK, Doan RA, Weihl CC, Milbrandt J, DiAntonio A. TMEM184b Promotes Axon Degeneration and Neuromuscular Junction Maintenance. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 36: 4681-9. PMID 27122027 DOI: 10.1523/Jneurosci.2893-15.2016  0.841
2016 Bae H, Chen S, Roche JP, Ai M, Wu C, Diantonio A, Graf ER. Rab3-GEF Controls Active Zone Development at the Drosophila Neuromuscular Junction. Eneuro. 3. PMID 27022630 DOI: 10.1523/ENEURO.0031-16.2016  0.802
2016 Brace EJ, DiAntonio A. Models of axon regeneration in Drosophila. Experimental Neurology. PMID 26996133 DOI: 10.1016/j.expneurol.2016.03.014  0.811
2016 Redmann V, Lamb CA, Hwang S, Orchard RC, Kim S, Razi M, Milam A, Park S, Yokoyama CC, Kambal A, Kreamalmeyer D, Bosch MK, Xiao M, Green K, Kim J, ... ... DiAntonio A, et al. Clec16a is Critical for Autolysosome Function and Purkinje Cell Survival. Scientific Reports. 6: 23326. PMID 26987296 DOI: 10.1038/Srep23326  0.58
2016 Gerdts J, Summers DW, Milbrandt J, DiAntonio A. Axon Self-Destruction: New Links among SARM1, MAPKs, and NAD+ Metabolism. Neuron. 89: 449-60. PMID 26844829 DOI: 10.1016/J.Neuron.2015.12.023  0.63
2016 Klionsky DJ, Abdelmohsen K, Abe A, Abedin MJ, Abeliovich H, Acevedo Arozena A, Adachi H, Adams CM, Adams PD, Adeli K, Adhihetty PJ, Adler SG, Agam G, Agarwal R, Aghi MK, ... ... DiAntonio A, et al. Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition). Autophagy. 12: 1-222. PMID 26799652 DOI: 10.1080/15548627.2015.1100356  0.669
2016 Walker LJ, Summers DW, Sasaki Y, Brace E, Milbrandt J, DiAntonio A. Author response: MAPK signaling promotes axonal degeneration by speeding the turnover of the axonal maintenance factor NMNAT2 Elife. DOI: 10.7554/Elife.22540.016  0.824
2016 Sasaki Y, Nakagawa T, Mao X, DiAntonio A, Milbrandt J. Author response: NMNAT1 inhibits axon degeneration via blockade of SARM1-mediated NAD+ depletion Elife. DOI: 10.7554/Elife.19749.024  0.606
2016 Hao Y, Frey E, Yoon C, Wong H, Nestorovski D, Holzman LB, Giger RJ, DiAntonio A, Collins C. Author response: An evolutionarily conserved mechanism for cAMP elicited axonal regeneration involves direct activation of the dual leucine zipper kinase DLK Elife. DOI: 10.7554/Elife.14048.013  0.749
2015 Gerdts J, Brace EJ, Sasaki Y, DiAntonio A, Milbrandt J. Neurobiology. SARM1 activation triggers axon degeneration locally via NAD⁺ destruction. Science (New York, N.Y.). 348: 453-7. PMID 25908823 DOI: 10.1126/Science.1258366  0.835
2015 Valakh V, Frey E, Babetto E, Walker LJ, DiAntonio A. Cytoskeletal disruption activates the DLK/JNK pathway, which promotes axonal regeneration and mimics a preconditioning injury. Neurobiology of Disease. 77: 13-25. PMID 25726747 DOI: 10.1016/J.Nbd.2015.02.014  0.766
2015 Frey E, Valakh V, Karney-Grobe S, Shi Y, Milbrandt J, DiAntonio A. An in vitro assay to study induction of the regenerative state in sensory neurons. Experimental Neurology. 263: 350-63. PMID 25447942 DOI: 10.1016/J.Expneurol.2014.10.012  0.75
2014 Ehmann N, van de Linde S, Alon A, Ljaschenko D, Keung XZ, Holm T, Rings A, DiAntonio A, Hallermann S, Ashery U, Heckmann M, Sauer M, Kittel RJ. Quantitative super-resolution imaging of Bruchpilot distinguishes active zone states. Nature Communications. 5: 4650. PMID 25130366 DOI: 10.1038/Ncomms5650  0.342
2014 Summers DW, DiAntonio A, Milbrandt J. Mitochondrial dysfunction induces Sarm1-dependent cell death in sensory neurons. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 34: 9338-50. PMID 25009267 DOI: 10.1523/Jneurosci.0877-14.2014  0.524
2014 Brace EJ, Wu C, Valakh V, DiAntonio A. SkpA restrains synaptic terminal growth during development and promotes axonal degeneration following injury. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 34: 8398-410. PMID 24948796 DOI: 10.1523/Jneurosci.4715-13.2014  0.849
2014 Zheng X, Valakh V, Diantonio A, Ben-Shahar Y. Natural antisense transcripts regulate the neuronal stress response and excitability. Elife. 3: e01849. PMID 24642409 DOI: 10.7554/Elife.01849  0.674
2014 Shin JE, Geisler S, DiAntonio A. Dynamic regulation of SCG10 in regenerating axons after injury. Experimental Neurology. 252: 1-11. PMID 24246279 DOI: 10.1016/j.expneurol.2013.11.007  0.634
2014 Zheng X, Valakh V, DiAntonio A, Ben-Shahar Y. Author response: Natural antisense transcripts regulate the neuronal stress response and excitability Elife. DOI: 10.7554/Elife.01849.021  0.66
2013 Valakh V, Walker LJ, Skeath JB, DiAntonio A. Loss of the spectraplakin short stop activates the DLK injury response pathway in Drosophila. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 33: 17863-73. PMID 24198375 DOI: 10.1523/Jneurosci.2196-13.2013  0.775
2013 Gerdts J, Summers DW, Sasaki Y, DiAntonio A, Milbrandt J. Sarm1-mediated axon degeneration requires both SAM and TIR interactions. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 33: 13569-80. PMID 23946415 DOI: 10.1523/Jneurosci.1197-13.2013  0.654
2013 Babetto E, Beirowski B, Russler EV, Milbrandt J, DiAntonio A. The Phr1 ubiquitin ligase promotes injury-induced axon self-destruction. Cell Reports. 3: 1422-9. PMID 23665224 DOI: 10.1016/J.Celrep.2013.04.013  0.63
2013 Welsbie DS, Yang Z, Ge Y, Mitchell KL, Zhou X, Martin SE, Berlinicke CA, Hackler L, Fuller J, Fu J, Cao LH, Han B, Auld D, Xue T, Hirai S, ... ... DiAntonio A, et al. Functional genomic screening identifies dual leucine zipper kinase as a key mediator of retinal ganglion cell death. Proceedings of the National Academy of Sciences of the United States of America. 110: 4045-50. PMID 23431148 DOI: 10.1073/Pnas.1211284110  0.362
2012 Shin JE, Miller BR, Babetto E, Cho Y, Sasaki Y, Qayum S, Russler EV, Cavalli V, Milbrandt J, DiAntonio A. SCG10 is a JNK target in the axonal degeneration pathway. Proceedings of the National Academy of Sciences of the United States of America. 109: E3696-705. PMID 23188802 DOI: 10.1073/Pnas.1216204109  0.777
2012 Graf ER, Valakh V, Wright CM, Wu C, Liu Z, Zhang YQ, DiAntonio A. RIM promotes calcium channel accumulation at active zones of the Drosophila neuromuscular junction. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 32: 16586-96. PMID 23175814 DOI: 10.1523/Jneurosci.0965-12.2012  0.812
2012 Lee AR, Lamb RR, Chang JH, Erdmann-Gilmore P, Lichti CF, Rohrs HW, Malone JP, Wairkar YP, DiAntonio A, Townsend RR, Culican SM. Identification of potential mediators of retinotopic mapping: a comparative proteomic analysis of optic nerve from WT and Phr1 retinal knockout mice. Journal of Proteome Research. 11: 5515-26. PMID 22985349 DOI: 10.1021/Pr300767A  0.789
2012 Han S, Kim S, Bahl S, Li L, Burande CF, Smith N, James M, Beauchamp RL, Bhide P, DiAntonio A, Ramesh V. The E3 ubiquitin ligase protein associated with Myc (Pam) regulates mammalian/mechanistic target of rapamycin complex 1 (mTORC1) signaling in vivo through N- and C-terminal domains. The Journal of Biological Chemistry. 287: 30063-72. PMID 22798074 DOI: 10.1074/Jbc.M112.353987  0.458
2012 Shin JE, Cho Y, Beirowski B, Milbrandt J, Cavalli V, DiAntonio A. Dual leucine zipper kinase is required for retrograde injury signaling and axonal regeneration. Neuron. 74: 1015-22. PMID 22726832 DOI: 10.1016/J.Neuron.2012.04.028  0.7
2012 Kim S, DiAntonio A. A role for the membrane Golgi protein Ema in autophagy. Autophagy. 8: 1269-70. PMID 22713284 DOI: 10.4161/auto.20871  0.532
2012 Valakh V, Naylor SA, Berns DS, DiAntonio A. A large-scale RNAi screen identifies functional classes of genes shaping synaptic development and maintenance. Developmental Biology. 366: 163-71. PMID 22542760 DOI: 10.1016/J.Ydbio.2012.04.008  0.826
2012 Bhattacharya MR, Gerdts J, Naylor SA, Royse EX, Ebstein SY, Sasaki Y, Milbrandt J, DiAntonio A. A model of toxic neuropathy in Drosophila reveals a role for MORN4 in promoting axonal degeneration. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 32: 5054-61. PMID 22496551 DOI: 10.1523/Jneurosci.4951-11.2012  0.81
2012 Kim S, Naylor SA, DiAntonio A. Drosophila Golgi membrane protein Ema promotes autophagosomal growth and function. Proceedings of the National Academy of Sciences of the United States of America. 109: E1072-81. PMID 22493244 DOI: 10.1073/Pnas.1120320109  0.789
2012 Naylor SA, DiAntonio A. EGFR signaling modulates synaptic connectivity via Gurken. Developmental Neurobiology. 72: 1229-42. PMID 22021126 DOI: 10.1002/Dneu.20992  0.807
2011 Shin JE, DiAntonio A. Highwire regulates guidance of sister axons in the Drosophila mushroom body. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 31: 17689-700. PMID 22131429 DOI: 10.1523/JNEUROSCI.3902-11.2011  0.666
2011 Graf ER, Heerssen HM, Wright CM, Davis GW, DiAntonio A. Stathmin is required for stability of the Drosophila neuromuscular junction. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 31: 15026-34. PMID 22016536 DOI: 10.1523/Jneurosci.2024-11.2011  0.743
2011 Tian X, Li J, Valakh V, DiAntonio A, Wu C. Drosophila Rae1 controls the abundance of the ubiquitin ligase Highwire in post-mitotic neurons. Nature Neuroscience. 14: 1267-75. PMID 21874015 DOI: 10.1038/Nn.2922  0.84
2011 Weng YL, Liu N, DiAntonio A, Broihier HT. The cytoplasmic adaptor protein Caskin mediates Lar signal transduction during Drosophila motor axon guidance. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 31: 4421-33. PMID 21430143 DOI: 10.1523/Jneurosci.5230-10.2011  0.472
2011 Daniels RW, Miller BR, DiAntonio A. Increased vesicular glutamate transporter expression causes excitotoxic neurodegeneration. Neurobiology of Disease. 41: 415-20. PMID 20951206 DOI: 10.1016/j.nbd.2010.10.009  0.754
2010 Vohra BP, Sasaki Y, Miller BR, Chang J, DiAntonio A, Milbrandt J. Amyloid precursor protein cleavage-dependent and -independent axonal degeneration programs share a common nicotinamide mononucleotide adenylyltransferase 1-sensitive pathway. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 30: 13729-38. PMID 20943913 DOI: 10.1523/Jneurosci.2939-10.2010  0.725
2010 Xiong X, Wang X, Ewanek R, Bhat P, Diantonio A, Collins CA. Protein turnover of the Wallenda/DLK kinase regulates a retrograde response to axonal injury. The Journal of Cell Biology. 191: 211-23. PMID 20921142 DOI: 10.1083/Jcb.201006039  0.747
2010 Grygoruk A, Fei H, Daniels RW, Miller BR, Chen A, DiAntonio A, Krantz DE. Vesicular neurotransmitter transporter trafficking in vivo: moving from cells to flies. Fly. 4: 302-5. PMID 20855951 DOI: 10.4161/Fly.4.4.13305  0.796
2010 Kim S, Wairkar YP, Daniels RW, DiAntonio A. The novel endosomal membrane protein Ema interacts with the class C Vps-HOPS complex to promote endosomal maturation. The Journal of Cell Biology. 188: 717-34. PMID 20194640 DOI: 10.1083/jcb.200911126  0.804
2010 DiAntonio A. Nedd4 branches out. Neuron. 65: 293-4. PMID 20159442 DOI: 10.1016/j.neuron.2010.01.028  0.417
2010 Grygoruk A, Fei H, Daniels RW, Miller BR, Diantonio A, Krantz DE. A tyrosine-based motif localizes a Drosophila vesicular transporter to synaptic vesicles in vivo. The Journal of Biological Chemistry. 285: 6867-78. PMID 20053989 DOI: 10.1074/Jbc.M109.073064  0.789
2010 Cheli VT, Daniels RW, Godoy R, Hoyle DJ, Kandachar V, Starcevic M, Martinez-Agosto JA, Poole S, DiAntonio A, Lloyd VK, Chang HC, Krantz DE, Dell'Angelica EC. Genetic modifiers of abnormal organelle biogenesis in a Drosophila model of BLOC-1 deficiency. Human Molecular Genetics. 19: 861-78. PMID 20015953 DOI: 10.1093/Hmg/Ddp555  0.702
2009 Graf ER, Daniels RW, Burgess RW, Schwarz TL, DiAntonio A. Rab3 dynamically controls protein composition at active zones. Neuron. 64: 663-77. PMID 20005823 DOI: 10.1016/j.neuron.2009.11.002  0.824
2009 Viquez NM, Füger P, Valakh V, Daniels RW, Rasse TM, DiAntonio A. PP2A and GSK-3beta act antagonistically to regulate active zone development. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 29: 11484-94. PMID 19759297 DOI: 10.1523/Jneurosci.5584-08.2009  0.793
2009 Culican SM, Bloom AJ, Weiner JA, DiAntonio A. Phr1 regulates retinogeniculate targeting independent of activity and ephrin-A signalling. Molecular and Cellular Neurosciences. 41: 304-12. PMID 19371781 DOI: 10.1016/j.mcn.2009.04.001  0.704
2009 Miller BR, Press C, Daniels RW, Sasaki Y, Milbrandt J, DiAntonio A. A dual leucine kinase-dependent axon self-destruction program promotes Wallerian degeneration. Nature Neuroscience. 12: 387-9. PMID 19287387 DOI: 10.1038/Nn.2290  0.82
2009 Wairkar YP, Toda H, Mochizuki H, Furukubo-Tokunaga K, Tomoda T, Diantonio A. Unc-51 controls active zone density and protein composition by downregulating ERK signaling. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 29: 517-28. PMID 19144852 DOI: 10.1523/JNEUROSCI.3848-08.2009  0.824
2009 Simon AF, Daniels R, Romero-Calderón R, Grygoruk A, Chang HY, Najibi R, Shamouelian D, Salazar E, Solomon M, Ackerson LC, Maidment NT, Diantonio A, Krantz DE. Drosophila vesicular monoamine transporter mutants can adapt to reduced or eliminated vesicular stores of dopamine and serotonin. Genetics. 181: 525-41. PMID 19033154 DOI: 10.1534/Genetics.108.094110  0.701
2009 Miller BR, Press C, Daniels RW, Sasaki Y, Milbrandt J, DiAntonio A. Erratum: A dual leucine kinase–dependent axon self-destruction program promotes Wallerian degeneration Nature Neuroscience. 12: 808-808. DOI: 10.1038/nn0609-808a  0.754
2008 Wairkar YP, Fradkin LG, Noordermeer JN, DiAntonio A. Synaptic defects in a Drosophila model of congenital muscular dystrophy. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 28: 3781-9. PMID 18385336 DOI: 10.1523/JNEUROSCI.0478-08.2008  0.808
2008 Daniels RW, Gelfand MV, Collins CA, DiAntonio A. Visualizing glutamatergic cell bodies and synapses in Drosophila larval and adult CNS. The Journal of Comparative Neurology. 508: 131-52. PMID 18302156 DOI: 10.1002/Cne.21670  0.815
2007 Bloom AJ, Miller BR, Sanes JR, DiAntonio A. The requirement for Phr1 in CNS axon tract formation reveals the corticostriatal boundary as a choice point for cortical axons. Genes & Development. 21: 2593-606. PMID 17901218 DOI: 10.1101/gad.1592107  0.771
2007 Wu C, Daniels RW, DiAntonio A. DFsn collaborates with Highwire to down-regulate the Wallenda/DLK kinase and restrain synaptic terminal growth. Neural Development. 2: 16. PMID 17697379 DOI: 10.1186/1749-8104-2-16  0.83
2007 Horiuchi D, Collins CA, Bhat P, Barkus RV, Diantonio A, Saxton WM. Control of a kinesin-cargo linkage mechanism by JNK pathway kinases. Current Biology : Cb. 17: 1313-7. PMID 17658258 DOI: 10.1016/J.Cub.2007.06.062  0.755
2007 Romero-Calderón R, Shome RM, Simon AF, Daniels RW, DiAntonio A, Krantz DE. A screen for neurotransmitter transporters expressed in the visual system of Drosophila melanogaster identifies three novel genes. Developmental Neurobiology. 67: 550-69. PMID 17443808 DOI: 10.1002/Dneu.20342  0.691
2007 Collins CA, DiAntonio A. Synaptic development: insights from Drosophila. Current Opinion in Neurobiology. 17: 35-42. PMID 17229568 DOI: 10.1016/J.Conb.2007.01.001  0.757
2006 DiAntonio A. Glutamate receptors at the Drosophila neuromuscular junction. International Review of Neurobiology. 75: 165-79. PMID 17137928 DOI: 10.1016/S0074-7742(06)75008-5  0.414
2006 Viquez NM, Li CR, Wairkar YP, DiAntonio A. The B' protein phosphatase 2A regulatory subunit well-rounded regulates synaptic growth and cytoskeletal stability at the Drosophila neuromuscular junction. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 26: 9293-303. PMID 16957085 DOI: 10.1523/JNEUROSCI.1740-06.2006  0.81
2006 Collins CA, Wairkar YP, Johnson SL, DiAntonio A. Highwire restrains synaptic growth by attenuating a MAP kinase signal. Neuron. 51: 57-69. PMID 16815332 DOI: 10.1016/J.Neuron.2006.05.026  0.819
2006 Daniels RW, DiAntonio A. Fast flies take a quantum leap. Neuron. 50: 667-9. PMID 16731505 DOI: 10.1016/j.neuron.2006.05.011  0.739
2006 Daniels RW, Collins CA, Chen K, Gelfand MV, Featherstone DE, DiAntonio A. A single vesicular glutamate transporter is sufficient to fill a synaptic vesicle. Neuron. 49: 11-6. PMID 16387635 DOI: 10.1016/J.Neuron.2005.11.032  0.814
2005 Wu C, Wairkar YP, Collins CA, DiAntonio A. Highwire function at the Drosophila neuromuscular junction: spatial, structural, and temporal requirements. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 25: 9557-66. PMID 16237161 DOI: 10.1523/Jneurosci.2532-05.2005  0.819
2005 Greer CL, Grygoruk A, Patton DE, Ley B, Romero-Calderon R, Chang HY, Houshyar R, Bainton RJ, Diantonio A, Krantz DE. A splice variant of the Drosophila vesicular monoamine transporter contains a conserved trafficking domain and functions in the storage of dopamine, serotonin, and octopamine. Journal of Neurobiology. 64: 239-58. PMID 15849736 DOI: 10.1002/Neu.20146  0.321
2005 Marrus SB, DiAntonio A. Investigating the safety factor at an invertebrate neuromuscular junction. Journal of Neurobiology. 63: 62-9. PMID 15685612 DOI: 10.1002/neu.20120  0.811
2004 Daniels RW, Collins CA, Gelfand MV, Dant J, Brooks ES, Krantz DE, DiAntonio A. Increased expression of the Drosophila vesicular glutamate transporter leads to excess glutamate release and a compensatory decrease in quantal content. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 24: 10466-74. PMID 15548661 DOI: 10.1523/Jneurosci.3001-04.2004  0.821
2004 DiAntonio A, Hicke L. Ubiquitin-dependent regulation of the synapse. Annual Review of Neuroscience. 27: 223-46. PMID 15217332 DOI: 10.1146/annurev.neuro.27.070203.144317  0.477
2004 Marrus SB, DiAntonio A. Preferential localization of glutamate receptors opposite sites of high presynaptic release. Current Biology : Cb. 14: 924-31. PMID 15182665 DOI: 10.1016/j.cub.2004.05.047  0.792
2004 Pawlu C, DiAntonio A, Heckmann M. Postfusional control of quantal current shape. Neuron. 42: 607-18. PMID 15157422 DOI: 10.1016/S0896-6273(04)00269-7  0.384
2004 Collins CA, DiAntonio A. Coordinating synaptic growth without being a nervous wreck. Neuron. 41: 489-91. PMID 14980197 DOI: 10.1016/S0896-6273(04)00078-9  0.739
2004 Marrus SB, Portman SL, Allen MJ, Moffat KG, DiAntonio A. Differential localization of glutamate receptor subunits at the Drosophila neuromuscular junction. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 24: 1406-15. PMID 14960613 DOI: 10.1523/JNEUROSCI.1575-03.2004  0.816
2002 Hegde AN, DiAntonio A. Ubiquitin and the synapse. Nature Reviews. Neuroscience. 3: 854-61. PMID 12415293 DOI: 10.1038/nrn961  0.45
2002 Fradkin LG, Kamphorst JT, DiAntonio A, Goodman CS, Noordermeer JN. Genomewide analysis of the Drosophila tetraspanins reveals a subset with similar function in the formation of the embryonic synapse. Proceedings of the National Academy of Sciences of the United States of America. 99: 13663-8. PMID 12370414 DOI: 10.1073/pnas.212511099  0.633
2001 DiAntonio A, Haghighi AP, Portman SL, Lee JD, Amaranto AM, Goodman CS. Ubiquitination-dependent mechanisms regulate synaptic growth and function. Nature. 412: 449-52. PMID 11473321 DOI: 10.1038/35086595  0.662
2000 DiAntonio A. Regulating receptor levels at a developing synapse. Neuron. 27: 5-7. PMID 10939323 DOI: 10.1016/S0896-6273(00)00022-2  0.387
2000 DiAntonio A. Neurobiology. Translating activity into plasticity. Nature. 405: 1011-2. PMID 10890430 DOI: 10.1038/35016684  0.448
2000 Wan HI, DiAntonio A, Fetter RD, Bergstrom K, Strauss R, Goodman CS. Highwire regulates synaptic growth in Drosophila. Neuron. 26: 313-29. PMID 10839352 DOI: 10.1016/S0896-6273(00)81166-6  0.756
1999 DiAntonio A. Learning something ORIGINal at the Drosophila neuromuscular junction. Neuron. 23: 1-2. PMID 10402184 DOI: 10.1016/S0896-6273(00)80743-6  0.426
1999 DiAntonio A, Petersen SA, Heckmann M, Goodman CS. Glutamate receptor expression regulates quantal size and quantal content at the Drosophila neuromuscular junction. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 19: 3023-32. PMID 10191319 DOI: 10.1523/Jneurosci.19-08-03023.1999  0.629
1998 Reist NE, Buchanan J, Li J, DiAntonio A, Buxton EM, Schwarz TL. Morphologically docked synaptic vesicles are reduced in synaptotagmin mutants of Drosophila. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 18: 7662-73. PMID 9742137 DOI: 10.1523/Jneurosci.18-19-07662.1998  0.571
1998 Davis GW, DiAntonio A, Petersen SA, Goodman CS. Postsynaptic PKA controls quantal size and reveals a retrograde signal that regulates presynaptic transmitter release in Drosophila. Neuron. 20: 305-15. PMID 9491991 DOI: 10.1016/S0896-6273(00)80458-4  0.727
1997 Petersen SA, Fetter RD, Noordermeer JN, Goodman CS, DiAntonio A. Genetic analysis of glutamate receptors in Drosophila reveals a retrograde signal regulating presynaptic transmitter release. Neuron. 19: 1237-48. PMID 9427247 DOI: 10.1016/S0896-6273(00)80415-8  0.625
1995 Parfitt K, Reist N, Li J, Burgess R, Deitcher D, DiAntonio A, Schwarz TL. Drosophila genetics and the functions of synaptic proteins. Cold Spring Harbor Symposia On Quantitative Biology. 60: 371-7. PMID 8824410 DOI: 10.1101/Sqb.1995.060.01.041  0.639
1994 Broadie K, Bellen HJ, DiAntonio A, Littleton JT, Schwarz TL. Absence of synaptotagmin disrupts excitation-secretion coupling during synaptic transmission. Proceedings of the National Academy of Sciences of the United States of America. 91: 10727-31. PMID 7938019 DOI: 10.1073/pnas.91.22.10727  0.552
1994 DiAntonio A, Schwarz TL. The effect on synaptic physiology of synaptotagmin mutations in Drosophila. Neuron. 12: 909-20. PMID 7909234 DOI: 10.1016/0896-6273(94)90342-5  0.584
1993 DiAntonio A, Burgess RW, Chin AC, Deitcher DL, Scheller RH, Schwarz TL. Identification and characterization of Drosophila genes for synaptic vesicle proteins. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 13: 4924-35. PMID 8229205 DOI: 10.1523/Jneurosci.13-11-04924.1993  0.672
1993 DiAntonio A, Parfitt KD, Schwarz TL. Synaptic transmission persists in synaptotagmin mutants of Drosophila. Cell. 73: 1281-90. PMID 8100740 DOI: 10.1016/0092-8674(93)90356-U  0.573
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