Yuri Persidsky, M.D., Ph.D - Publications

Affiliations: 
Pathology and Laboratory Medicine Temple University, Philadelphia, PA, United States 
Area:
blood-brain barrier, neuroinflammation
Website:
http://www.temple.edu/medicine/faculty/p/persidsky.asp?pms=(persidsky%20y%5Bau%5D)

131 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2020 Rom S, Heldt NA, Gajghate S, Seliga A, Reichenbach NL, Persidsky Y. Hyperglycemia and advanced glycation end products disrupt BBB and promote occludin and claudin-5 protein secretion on extracellular microvesicles. Scientific Reports. 10: 7274. PMID 32350344 DOI: 10.1038/s41598-020-64349-x  1
2020 Heldt NA, Seliga A, Winfield M, Gajghate S, Reichenbach N, Yu X, Rom S, Tenneti A, May D, Gregory BD, Persidsky Y. Electronic cigarette exposure disrupts blood-brain barrier integrity and promotes neuroinflammation. Brain, Behavior, and Immunity. PMID 32243899 DOI: 10.1016/j.bbi.2020.03.034  1
2020 Bernstein DL, Gajghate S, Reichenbach NL, Winfield M, Persidsky Y, Heldt NA, Rom S. let-7g counteracts endothelial dysfunction and ameliorating neurological functions in mouse ischemia/reperfusion stroke model. Brain, Behavior, and Immunity. PMID 32017988 DOI: 10.1016/j.bbi.2020.01.026  1
2020 Marcos-Contreras OA, Greineder CF, Kiseleva RY, Parhiz H, Walsh LR, Zuluaga-Ramirez V, Myerson JW, Hood ED, Villa CH, Tombacz I, Pardi N, Seliga A, Mui BL, Tam YK, Glassman PM, ... ... Persidsky Y, et al. Selective targeting of nanomedicine to inflamed cerebral vasculature to enhance the blood-brain barrier. Proceedings of the National Academy of Sciences of the United States of America. PMID 32005712 DOI: 10.1073/pnas.1912012117  1
2019 Bernstein DL, Zuluaga-Ramirez V, Gajghate S, Reichenbach NL, Polyak B, Persidsky Y, Rom S. miR-98 reduces endothelial dysfunction by protecting blood-brain barrier (BBB) and improves neurological outcomes in mouse ischemia/reperfusion stroke model. Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism. 271678X19882264. PMID 31601141 DOI: 10.1177/0271678X19882264  1
2019 Hill JD, Zuluaga-Ramirez V, Gajghate S, Winfield M, Persidsky Y. Chronic Intrahippocampal Infusion of HIV-1 Neurotoxic Proteins: A Novel Mouse Model of HIV-1 Associated Inflammation and Neural Stem Cell Dysfunction. Journal of Neuroimmune Pharmacology : the Official Journal of the Society On Neuroimmune Pharmacology. PMID 30905008 DOI: 10.1007/s11481-019-09846-1  1
2019 Marcos-Contreras OA, Brenner JS, Kiseleva RY, Zuluaga-Ramirez V, Greineder CF, Villa CH, Hood ED, Myerson JW, Muro S, Persidsky Y, Muzykantov VR. Combining vascular targeting and the local first pass provides 100-fold higher uptake of ICAM-1-targeted vs untargeted nanocarriers in the inflamed brain. Journal of Controlled Release : Official Journal of the Controlled Release Society. PMID 30871995 DOI: 10.1016/j.jconrel.2019.03.008  1
2018 Hill JD, Zuluaga-Ramirez V, Gajghate S, Winfield M, Sriram U, Rom S, Persidsky Y. Activation of GPR55 induces neuroprotection of hippocampal neurogenesis and immune responses of neural stem cells following chronic, systemic inflammation. Brain, Behavior, and Immunity. PMID 30465881 DOI: 10.1016/j.bbi.2018.11.017  1
2018 Rom S, Zuluaga-Ramirez V, Gajghate S, Seliga A, Winfield M, Heldt NA, Kolpakov MA, Bashkirova YV, Sabri AK, Persidsky Y. Hyperglycemia-Driven Neuroinflammation Compromises BBB Leading to Memory Loss in Both Diabetes Mellitus (DM) Type 1 and Type 2 Mouse Models. Molecular Neurobiology. PMID 29974394 DOI: 10.1007/s12035-018-1195-5  1
2018 Hill JD, Zuluaga-Ramirez V, Gajghate S, Winfield M, Persidsky Y. Activation of GPR55 increases neural stem cell proliferation and promotes early adult hippocampal neurogenesis. British Journal of Pharmacology. PMID 29888782 DOI: 10.1111/bph.14387  1
2018 Seliga A, Lee MH, Fernandes NC, Zuluaga-Ramirez V, Didukh M, Persidsky Y, Potula R, Gallucci S, Sriram U. Kallikrein-Kinin System Suppresses Type I Interferon Responses: A Novel Pathway of Interferon Regulation. Frontiers in Immunology. 9: 156. PMID 29456540 DOI: 10.3389/fimmu.2018.00156  1
2018 Rom S, Zuluaga-Ramirez V, Reichenbach NL, Erickson MA, Winfield M, Gajghate S, Christofidou-Solomidou M, Jordan-Sciutto KL, Persidsky Y. Secoisolariciresinol diglucoside is a blood-brain barrier protective and anti-inflammatory agent: implications for neuroinflammation. Journal of Neuroinflammation. 15: 25. PMID 29373982 DOI: 10.1186/s12974-018-1065-0  1
2017 Bogush M, Heldt NA, Persidsky Y. Blood Brain Barrier Injury in Diabetes: Unrecognized Effects on Brain and Cognition. Journal of Neuroimmune Pharmacology : the Official Journal of the Society On Neuroimmune Pharmacology. PMID 28555373 DOI: 10.1007/s11481-017-9752-7  0.6
2017 Andrews AM, Lutton EM, Cannella LA, Reichenbach N, Razmpour R, Seasock MJ, Kaspin SJ, Merkel SF, Langford D, Persidsky Y, Ramirez SH. Characterization of human fetal brain endothelial cells reveals barrier properties suitable for in vitro modeling of the BBB with syngenic co-cultures. Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism. 271678X17708690. PMID 28534661 DOI: 10.1177/0271678X17708690  0.8
2016 Mukhopadhyay P, Horváth B, Rajesh M, Varga ZV, Gariani K, Ryu D, Cao Z, Holovac E, Park O, Zhou Z, Xu MJ, Wang W, Godlewski G, Paloczi J, Nemeth BT, ... Persidsky Y, et al. PARP inhibition protects against alcoholic and nonalcoholic steatohepatitis. Journal of Hepatology. PMID 27984176 DOI: 10.1016/j.jhep.2016.10.023  1
2016 Rom S, Zuluaga-Ramirez V, Reichenbach NL, Dykstra H, Gajghate S, Pacher P, Persidsky Y. PARP inhibition in leukocytes diminishes inflammation via effects on integrins/cytoskeleton and protects the blood-brain barrier. Journal of Neuroinflammation. 13: 254. PMID 27677851 DOI: 10.1186/s12974-016-0729-x  1
2016 Merkel SF, Razmpour R, Lutton EM, Tallarida CS, Heldt NA, Cannella LA, Persidsky Y, Rawls SM, Ramirez SH. Adolescent Traumatic Brain Injury Induces Chronic Mesolimbic Neuroinflammation with Concurrent Enhancement in the Rewarding Effects of Cocaine in Mice during Adulthood. Journal of Neurotrauma. PMID 27026056 DOI: 10.1089/neu.2015.4275  1
2015 Persidsky Y, Hill J, Zhang M, Dykstra H, Winfield M, Reichenbach NL, Potula R, Mukherjee A, Ramirez SH, Rom S. Dysfunction of brain pericytes in chronic neuroinflammation. Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism. PMID 26661157 DOI: 10.1177/0271678X15606149  1
2015 Hammer AM, Morris NL, Cannon AR, Shults JA, Curtis B, Casey CA, Sueblinvong V, Persidsky Y, Nixon K, Brown LA, Waldschmidt T, Mandrekar P, Kovacs EJ, Choudhry MA. Summary of the 2014 Alcohol and Immunology Research Interest Group (AIRIG) meeting. Alcohol (Fayetteville, N.Y.). PMID 26520175 DOI: 10.1016/j.alcohol.2015.09.002  0.32
2015 Zuluaga-Ramirez V, Rom S, Persidsky Y. Craniula: A cranial window technique for prolonged imaging of brain surface vasculature with simultaneous adjacent intracerebral injection. Fluids and Barriers of the Cns. 12: 24. PMID 26507826 DOI: 10.1186/s12987-015-0021-y  1
2015 Rom S, Reichenbach NL, Dykstra H, Persidsky Y. The dual action of poly(ADP-ribose) polymerase -1 (PARP-1) inhibition in HIV-1 infection: HIV-1 LTR inhibition and diminution in Rho GTPase activity. Frontiers in Microbiology. 6: 878. PMID 26379653 DOI: 10.3389/fmicb.2015.00878  0.32
2015 Rom S, Dykstra H, Zuluaga-Ramirez V, Reichenbach NL, Persidsky Y. miR-98 and let-7g* protect the blood-brain barrier under neuroinflammatory conditions. Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism. PMID 26126865 DOI: 10.1038/jcbfm.2015.154  1
2015 Persidsky Y. Insights into end-organ injury in HIV infection: dynamics of monocyte trafficking to the brain in SIV encephalitis. The American Journal of Pathology. 185: 1548-51. PMID 25963553 DOI: 10.1016/j.ajpath.2015.03.001  1
2015 Watters AK, Rom S, Hill JD, Dematatis MK, Zhou Y, Merkel SF, Andrews AM, Cena J, Potula R, Skuba A, Son YJ, Persidsky Y, Ramirez SH. Identification and dynamic regulation of tight junction protein expression in human neural stem cells. Stem Cells and Development. 24: 1377-89. PMID 25892136 DOI: 10.1089/scd.2014.0497  1
2015 Persidsky Y, Fan S, Dykstra H, Reichenbach NL, Rom S, Ramirez SH. Activation of Cannabinoid Type Two Receptors (CB2) Diminish Inflammatory Responses in Macrophages and Brain Endothelium. Journal of Neuroimmune Pharmacology : the Official Journal of the Society On Neuroimmune Pharmacology. 10: 302-8. PMID 25666933 DOI: 10.1007/s11481-015-9591-3  1
2015 Rom S, Zuluaga-Ramirez V, Dykstra H, Reichenbach NL, Ramirez SH, Persidsky Y. Poly(ADP-ribose) polymerase-1 inhibition in brain endothelium protects the blood-brain barrier under physiologic and neuroinflammatory conditions. Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism. 35: 28-36. PMID 25248836 DOI: 10.1038/jcbfm.2014.167  1
2014 Hill J, Rom S, Ramirez SH, Persidsky Y. Emerging roles of pericytes in the regulation of the neurovascular unit in health and disease. Journal of Neuroimmune Pharmacology : the Official Journal of the Society On Neuroimmune Pharmacology. 9: 591-605. PMID 25119834 DOI: 10.1007/s11481-014-9557-x  1
2014 Haskó J, Fazakas C, Molnár J, Nyúl-Tóth Á, Herman H, Hermenean A, Wilhelm I, Persidsky Y, Krizbai IA. CB2 receptor activation inhibits melanoma cell transmigration through the blood-brain barrier. International Journal of Molecular Sciences. 15: 8063-74. PMID 24815068 DOI: 10.3390/ijms15058063  1
2014 Li H, Singh S, Potula R, Persidsky Y, Kanmogne GD. Dysregulation of claudin-5 in HIV-induced interstitial pneumonitis and lung vascular injury. Protective role of peroxisome proliferator-activated receptor-γ. American Journal of Respiratory and Critical Care Medicine. 190: 85-97. PMID 22345580 DOI: 10.1164/rccm.201106-1151OC  1
2014 Persidsky Y, Gofman L, Potula R. Alcohol and neurodegeneration Neuroinflammation and Neurodegeneration. 511-526. DOI: 10.1007/978-1-4939-1071-7_24  1
2013 Shuvaev VV, Han J, Tliba S, Arguiri E, Christofidou-Solomidou M, Ramirez SH, Dykstra H, Persidsky Y, Atochin DN, Huang PL, Muzykantov VR. Anti-inflammatory effect of targeted delivery of SOD to endothelium: mechanism, synergism with NO donors and protective effects in vitro and in vivo. Plos One. 8: e77002. PMID 24146950 DOI: 10.1371/journal.pone.0077002  1
2013 Rom S, Zuluaga-Ramirez V, Dykstra H, Reichenbach NL, Pacher P, Persidsky Y. Selective activation of cannabinoid receptor 2 in leukocytes suppresses their engagement of the brain endothelium and protects the blood-brain barrier. The American Journal of Pathology. 183: 1548-58. PMID 24055259 DOI: 10.1016/j.ajpath.2013.07.033  1
2013 Zhou Y, Bao R, Haigwood NL, Persidsky Y, Ho WZ. SIV infection of rhesus macaques of Chinese origin: a suitable model for HIV infection in humans. Retrovirology. 10: 89. PMID 23947613 DOI: 10.1186/1742-4690-10-89  1
2013 Rom S, Persidsky Y. Cannabinoid receptor 2: potential role in immunomodulation and neuroinflammation. Journal of Neuroimmune Pharmacology : the Official Journal of the Society On Neuroimmune Pharmacology. 8: 608-20. PMID 23471521 DOI: 10.1007/s11481-013-9445-9  1
2013 Ramirez SH, Reichenbach NL, Fan S, Rom S, Merkel SF, Wang X, Ho WZ, Persidsky Y. Attenuation of HIV-1 replication in macrophages by cannabinoid receptor 2 agonists. Journal of Leukocyte Biology. 93: 801-10. PMID 23463725 DOI: 10.1189/jlb.1012523  1
2013 Ramirez SH, Fan S, Dykstra H, Rom S, Mercer A, Reichenbach NL, Gofman L, Persidsky Y. Inhibition of glycogen synthase kinase 3β promotes tight junction stability in brain endothelial cells by half-life extension of occludin and claudin-5. Plos One. 8: e55972. PMID 23418486 DOI: 10.1371/journal.pone.0055972  1
2013 Li J, Wang Y, Wang X, Ye L, Zhou Y, Persidsky Y, Ho W. Immune activation of human brain microvascular endothelial cells inhibits HIV replication in macrophages. Blood. 121: 2934-42. PMID 23401273 DOI: 10.1182/blood-2012-08-450353  1
2013 Zhou Y, Guo M, Wang X, Li J, Wang Y, Ye L, Dai M, Zhou L, Persidsky Y, Ho W. TLR3 activation efficiency by high or low molecular mass poly I:C. Innate Immunity. 19: 184-92. PMID 23035017 DOI: 10.1177/1753425912459975  1
2013 Persidsky Y, Ho WZ, Wang X, Potula R. Alcohol abuse, HIV-1, and hepatitis c infection Neural-Immune Interactions in Brain Function and Alcohol Related Disorders. 509-533. DOI: 10.1007/978-1-4614-4729-0_16  1
2012 Rom S, Fan S, Reichenbach N, Dykstra H, Ramirez SH, Persidsky Y. Glycogen synthase kinase 3β inhibition prevents monocyte migration across brain endothelial cells via Rac1-GTPase suppression and down-regulation of active integrin conformation. The American Journal of Pathology. 181: 1414-25. PMID 22863953 DOI: 10.1016/j.ajpath.2012.06.018  1
2012 Ramirez SH, Haskó J, Skuba A, Fan S, Dykstra H, McCormick R, Reichenbach N, Krizbai I, Mahadevan A, Zhang M, Tuma R, Son YJ, Persidsky Y. Activation of cannabinoid receptor 2 attenuates leukocyte-endothelial cell interactions and blood-brain barrier dysfunction under inflammatory conditions. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 32: 4004-16. PMID 22442067 DOI: 10.1523/JNEUROSCI.4628-11.2012  1
2011 Ashraf T, Ronaldson PT, Persidsky Y, Bendayan R. Regulation of P-glycoprotein by human immunodeficiency virus-1 in primary cultures of human fetal astrocytes. Journal of Neuroscience Research. 89: 1773-82. PMID 21826700 DOI: 10.1002/jnr.22720  1
2011 Haorah J, Floreani NA, Knipe B, Persidsky Y. Stabilization of superoxide dismutase by acetyl-l-carnitine in human brain endothelium during alcohol exposure: novel protective approach. Free Radical Biology & Medicine. 51: 1601-9. PMID 21782933 DOI: 10.1016/j.freeradbiomed.2011.06.020  1
2011 Persidsky Y, Ho W, Ramirez SH, Potula R, Abood ME, Unterwald E, Tuma R. HIV-1 infection and alcohol abuse: neurocognitive impairment, mechanisms of neurodegeneration and therapeutic interventions. Brain, Behavior, and Immunity. 25: S61-70. PMID 21397004 DOI: 10.1016/j.bbi.2011.03.001  1
2011 Li J, Ye L, Cook DR, Wang X, Liu J, Kolson DL, Persidsky Y, Ho WZ. Soybean-derived Bowman-Birk inhibitor inhibits neurotoxicity of LPS-activated macrophages. Journal of Neuroinflammation. 8: 15. PMID 21324129 DOI: 10.1186/1742-2094-8-15  1
2010 Rump TJ, Abdul Muneer PM, Szlachetka AM, Lamb A, Haorei C, Alikunju S, Xiong H, Keblesh J, Liu J, Zimmerman MC, Jones J, Donohue TM, Persidsky Y, Haorah J. Acetyl-L-carnitine protects neuronal function from alcohol-induced oxidative damage in the brain. Free Radical Biology & Medicine. 49: 1494-504. PMID 20708681 DOI: 10.1016/j.freeradbiomed.2010.08.011  1
2010 Potula R, Hawkins BJ, Cenna JM, Fan S, Dykstra H, Ramirez SH, Morsey B, Brodie MR, Persidsky Y. Methamphetamine causes mitrochondrial oxidative damage in human T lymphocytes leading to functional impairment. Journal of Immunology (Baltimore, Md. : 1950). 185: 2867-76. PMID 20668216 DOI: 10.4049/jimmunol.0903691  1
2010 Ye L, Wang S, Wang X, Zhou Y, Li J, Persidsky Y, Ho W. Alcohol impairs interferon signaling and enhances full cycle hepatitis C virus JFH-1 infection of human hepatocytes. Drug and Alcohol Dependence. 112: 107-16. PMID 20646875 DOI: 10.1016/j.drugalcdep.2010.05.008  1
2010 Ramirez SH, Fan S, Dykstra H, Reichenbach N, Del Valle L, Potula R, Phipps RP, Maggirwar SB, Persidsky Y. Dyad of CD40/CD40 ligand fosters neuroinflammation at the blood-brain barrier and is regulated via JNK signaling: implications for HIV-1 encephalitis. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 30: 9454-64. PMID 20631174 DOI: 10.1523/JNEUROSCI.5796-09.2010  1
2010 Bernas MJ, Cardoso FL, Daley SK, Weinand ME, Campos AR, Ferreira AJ, Hoying JB, Witte MH, Brites D, Persidsky Y, Ramirez SH, Brito MA. Establishment of primary cultures of human brain microvascular endothelial cells to provide an in vitro cellular model of the blood-brain barrier. Nature Protocols. 5: 1265-72. PMID 20595955 DOI: 10.1038/nprot.2010.76  1
2010 Floreani NA, Rump TJ, Abdul Muneer PM, Alikunju S, Morsey BM, Brodie MR, Persidsky Y, Haorah J. Alcohol-induced interactive phosphorylation of Src and toll-like receptor regulates the secretion of inflammatory mediators by human astrocytes. Journal of Neuroimmune Pharmacology : the Official Journal of the Society On Neuroimmune Pharmacology. 5: 533-45. PMID 20379791 DOI: 10.1007/s11481-010-9213-z  1
2010 Ramirez SH, Fan S, Zhang M, Papugani A, Reichenbach N, Dykstra H, Mercer AJ, Tuma RF, Persidsky Y. Inhibition of glycogen synthase kinase 3beta (GSK3beta) decreases inflammatory responses in brain endothelial cells. The American Journal of Pathology. 176: 881-92. PMID 20056834 DOI: 10.2353/ajpath.2010.090671  1
2009 Ramirez SH, Potula R, Fan S, Eidem T, Papugani A, Reichenbach N, Dykstra H, Weksler BB, Romero IA, Couraud PO, Persidsky Y. Methamphetamine disrupts blood-brain barrier function by induction of oxidative stress in brain endothelial cells. Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism. 29: 1933-45. PMID 19654589 DOI: 10.1038/jcbfm.2009.112  1
2009 Xiong W, MacTaggart J, Knispel R, Worth J, Persidsky Y, Baxter BT. Blocking TNF-alpha attenuates aneurysm formation in a murine model. Journal of Immunology (Baltimore, Md. : 1950). 183: 2741-6. PMID 19620291 DOI: 10.4049/jimmunol.0803164  1
2009 Gendelman HE, Ding S, Gong N, Liu J, Ramirez SH, Persidsky Y, Mosley RL, Wang T, Volsky DJ, Xiong H. Monocyte chemotactic protein-1 regulates voltage-gated K+ channels and macrophage transmigration. Journal of Neuroimmune Pharmacology : the Official Journal of the Society On Neuroimmune Pharmacology. 4: 47-59. PMID 19034671 DOI: 10.1007/s11481-008-9135-1  1
2008 Haorah J, Ramirez SH, Floreani N, Gorantla S, Morsey B, Persidsky Y. Mechanism of alcohol-induced oxidative stress and neuronal injury. Free Radical Biology & Medicine. 45: 1542-50. PMID 18845238 DOI: 10.1016/j.freeradbiomed.2008.08.030  1
2008 Potula R, Ramirez SH, Knipe B, Leibhart J, Schall K, Heilman D, Morsey B, Mercer A, Papugani A, Dou H, Persidsky Y. Peroxisome proliferator-activated receptor-gamma activation suppresses HIV-1 replication in an animal model of encephalitis. Aids (London, England). 22: 1539-49. PMID 18670212 DOI: 10.1097/QAD.0b013e3283081e08  1
2008 Ronaldson PT, Persidsky Y, Bendayan R. Regulation of ABC membrane transporters in glial cells: relevance to the pharmacotherapy of brain HIV-1 infection. Glia. 56: 1711-35. PMID 18649402 DOI: 10.1002/glia.20725  1
2008 Potula R, Persidsky Y. Adding fuel to the fire: methamphetamine enhances HIV infection. The American Journal of Pathology. 172: 1467-70. PMID 18458093 DOI: 10.2353/ajpath.2008.080130  1
2008 Ramirez SH, Heilman D, Morsey B, Potula R, Haorah J, Persidsky Y. Activation of peroxisome proliferator-activated receptor gamma (PPARgamma) suppresses Rho GTPases in human brain microvascular endothelial cells and inhibits adhesion and transendothelial migration of HIV-1 infected monocytes. Journal of Immunology (Baltimore, Md. : 1950). 180: 1854-65. PMID 18209083  1
2008 Yamamoto M, Ramirez SH, Sato S, Kiyota T, Cerny RL, Kaibuchi K, Persidsky Y, Ikezu T. Phosphorylation of claudin-5 and occludin by rho kinase in brain endothelial cells. The American Journal of Pathology. 172: 521-33. PMID 18187566 DOI: 10.2353/ajpath.2008.070076  1
2008 Chaudhuri A, Yang B, Gendelman HE, Persidsky Y, Kanmogne GD. STAT1 signaling modulates HIV-1-induced inflammatory responses and leukocyte transmigration across the blood-brain barrier. Blood. 111: 2062-72. PMID 18003888 DOI: 10.1182/blood-2007-05-091207  1
2008 Haorah J, Schall K, Ramirez SH, Persidsky Y. Activation of protein tyrosine kinases and matrix metalloproteinases causes blood-brain barrier injury: Novel mechanism for neurodegeneration associated with alcohol abuse. Glia. 56: 78-88. PMID 17943953 DOI: 10.1002/glia.20596  1
2008 Chaudhuri A, Duan F, Morsey B, Persidsky Y, Kanmogne GD. HIV-1 activates proinflammatory and interferon-inducible genes in human brain microvascular endothelial cells: putative mechanisms of blood-brain barrier dysfunction. Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism. 28: 697-711. PMID 17940540 DOI: 10.1038/sj.jcbfm.9600567  1
2007 Persidsky Y, Fox H. Battle of animal models. Journal of Neuroimmune Pharmacology : the Official Journal of the Society On Neuroimmune Pharmacology. 2: 171-7. PMID 18040841 DOI: 10.1007/s11481-006-9046-y  1
2007 Liu J, Johnson TV, Lin J, Ramirez SH, Bronich TK, Caplan S, Persidsky Y, Gendelman HE, Kipnis J. T cell independent mechanism for copolymer-1-induced neuroprotection. European Journal of Immunology. 37: 3143-54. PMID 17948266 DOI: 10.1002/eji.200737398  1
2007 Ricardo-Dukelow M, Kadiu I, Rozek W, Schlautman J, Persidsky Y, Ciborowski P, Kanmogne GD, Gendelman HE. HIV-1 infected monocyte-derived macrophages affect the human brain microvascular endothelial cell proteome: new insights into blood-brain barrier dysfunction for HIV-1-associated dementia. Journal of Neuroimmunology. 185: 37-46. PMID 17321604 DOI: 10.1016/j.jneuroim.2007.01.004  1
2007 Haorah J, Ramirez SH, Schall K, Smith D, Pandya R, Persidsky Y. Oxidative stress activates protein tyrosine kinase and matrix metalloproteinases leading to blood-brain barrier dysfunction. Journal of Neurochemistry. 101: 566-76. PMID 17250680 DOI: 10.1111/j.1471-4159.2006.04393.x  1
2007 Haorah J, Knipe B, Gorantla S, Zheng J, Persidsky Y. Alcohol-induced blood-brain barrier dysfunction is mediated via inositol 1,4,5-triphosphate receptor (IP3R)-gated intracellular calcium release. Journal of Neurochemistry. 100: 324-36. PMID 17241155 DOI: 10.1111/j.1471-4159.2006.04245.x  1
2007 Hauser KF, El-Hage N, Stiene-Martin A, Maragos WF, Nath A, Persidsky Y, Volsky DJ, Knapp PE. HIV-1 neuropathogenesis: glial mechanisms revealed through substance abuse. Journal of Neurochemistry. 100: 567-86. PMID 17173547 DOI: 10.1111/j.1471-4159.2006.04227.x  1
2007 Spitzenberger TJ, Heilman D, Diekmann C, Batrakova EV, Kabanov AV, Gendelman HE, Elmquist WF, Persidsky Y. Novel delivery system enhances efficacy of antiretroviral therapy in animal model for HIV-1 encephalitis. Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism. 27: 1033-42. PMID 17063148 DOI: 10.1038/sj.jcbfm.9600414  1
2007 Kanmogne GD, Schall K, Leibhart J, Knipe B, Gendelman HE, Persidsky Y. HIV-1 gp120 compromises blood-brain barrier integrity and enhances monocyte migration across blood-brain barrier: implication for viral neuropathogenesis. Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism. 27: 123-34. PMID 16685256 DOI: 10.1038/sj.jcbfm.9600330  1
2006 Berman JW, Carson MJ, Chang L, Cox BM, Fox HS, Gonzalez RG, Hanson GR, Hauser KF, Ho WZ, Hong JS, Major EO, Maragos WF, Masliah E, McArthur JC, Miller DB, ... ... Persidsky Y, et al. NeuroAIDS, drug abuse, and inflammation: building collaborative research activities. Journal of Neuroimmune Pharmacology : the Official Journal of the Society On Neuroimmune Pharmacology. 1: 351-99. PMID 18040811 DOI: 10.1007/s11481-006-9048-9  1
2006 Persidsky Y, Ramirez SH, Haorah J, Kanmogne GD. Blood-brain barrier: structural components and function under physiologic and pathologic conditions. Journal of Neuroimmune Pharmacology : the Official Journal of the Society On Neuroimmune Pharmacology. 1: 223-36. PMID 18040800 DOI: 10.1007/s11481-006-9025-3  1
2006 Persidsky Y, Poluektova L. Immune privilege and HIV-1 persistence in the CNS. Immunological Reviews. 213: 180-94. PMID 16972904 DOI: 10.1111/j.1600-065X.2006.00440.x  1
2006 Potula R, Haorah J, Knipe B, Leibhart J, Chrastil J, Heilman D, Dou H, Reddy R, Ghorpade A, Persidsky Y. Alcohol abuse enhances neuroinflammation and impairs immune responses in an animal model of human immunodeficiency virus-1 encephalitis. The American Journal of Pathology. 168: 1335-44. PMID 16565506 DOI: 10.2353/ajpath.2006.051181  1
2006 Persidsky Y, Heilman D, Haorah J, Zelivyanskaya M, Persidsky R, Weber GA, Shimokawa H, Kaibuchi K, Ikezu T. Rho-mediated regulation of tight junctions during monocyte migration across the blood-brain barrier in HIV-1 encephalitis (HIVE). Blood. 107: 4770-80. PMID 16478881 DOI: 10.1182/blood-2005-11-4721  1
2005 Persidsky Y, Potula R, Haorah J. Rodent model systems for studies of HIV-1 associated dementia. Neurotoxicity Research. 8: 91-106. PMID 16260388 DOI: 10.1007/BF03033822  1
2005 Haorah J, Knipe B, Leibhart J, Ghorpade A, Persidsky Y. Alcohol-induced oxidative stress in brain endothelial cells causes blood-brain barrier dysfunction. Journal of Leukocyte Biology. 78: 1223-32. PMID 16204625 DOI: 10.1189/jlb.0605340  1
2005 Haorah J, Heilman D, Knipe B, Chrastil J, Leibhart J, Ghorpade A, Miller DW, Persidsky Y. Ethanol-induced activation of myosin light chain kinase leads to dysfunction of tight junctions and blood-brain barrier compromise. Alcoholism, Clinical and Experimental Research. 29: 999-1009. PMID 15976526 DOI: 10.1097/01.ALC.0000166944.79914.0A  1
2005 Potula R, Poluektova L, Knipe B, Chrastil J, Heilman D, Dou H, Takikawa O, Munn DH, Gendelman HE, Persidsky Y. Inhibition of indoleamine 2,3-dioxygenase (IDO) enhances elimination of virus-infected macrophages in an animal model of HIV-1 encephalitis. Blood. 106: 2382-90. PMID 15961516 DOI: 10.1182/blood-2005-04-1403  1
2005 Ghorpade A, Bruch L, Persidsky Y, Chin B, Brown WH, Borgmann K, Persidsky R, Wu L, Holter S, Cotter R, Faraci J, Heilman D, Meyer V, Potter JF, Swindells S, et al. Development of a rapid autopsy program for studies of brain immunity. Journal of Neuroimmunology. 163: 135-44. PMID 15885316 DOI: 10.1016/j.jneuroim.2005.01.021  1
2005 Ghorpade A, Persidsky Y, Swindells S, Borgmann K, Persidsky R, Holter S, Cotter R, Gendelman HE. Neuroinflammatory responses from microglia recovered from HIV-1-infected and seronegative subjects. Journal of Neuroimmunology. 163: 145-56. PMID 15869805 DOI: 10.1016/j.jneuroim.2005.01.022  1
2005 Gendelman HE, Persidsky Y. Infections of the nervous system. The Lancet. Neurology. 4: 12-3. PMID 15620853 DOI: 10.1016/S1474-4422(04)00951-2  1
2004 Batrakova EV, Zhang Y, Li Y, Li S, Vinogradov SV, Persidsky Y, Alakhov VY, Miller DW, Kabanov AV. Effects of pluronic P85 on GLUT1 and MCT1 transporters in the blood-brain barrier. Pharmaceutical Research. 21: 1993-2000. PMID 15587920 DOI: 10.1023/B:PHAM.0000048189.79606.6e  1
2004 Haorah J, Heilman D, Diekmann C, Osna N, Donohue TM, Ghorpade A, Persidsky Y. Alcohol and HIV decrease proteasome and immunoproteasome function in macrophages: implications for impaired immune function during disease. Cellular Immunology. 229: 139-48. PMID 15474528 DOI: 10.1016/j.cellimm.2004.07.005  1
2004 Nukuna A, Gendelman HE, Limoges J, Rasmussen J, Poluektova L, Ghorpade A, Persidsky Y. Levels of human immunodeficiency virus type 1 (HIV-1) replication in macrophages determines the severity of murine HIV-1 encephalitis. Journal of Neurovirology. 10: 82-90. PMID 14982744 DOI: 10.1080/13550280490268188  1
2004 Ryan LA, Peng H, Erichsen DA, Huang Y, Persidsky Y, Zhou Y, Gendelman HE, Zheng J. TNF-related apoptosis-inducing ligand mediates human neuronal apoptosis: links to HIV-1-associated dementia. Journal of Neuroimmunology. 148: 127-39. PMID 14975593 DOI: 10.1016/j.jneuroim.2003.11.019  1
2003 Persidsky Y, Gendelman HE. Mononuclear phagocyte immunity and the neuropathogenesis of HIV-1 infection. Journal of Leukocyte Biology. 74: 691-701. PMID 14595004 DOI: 10.1189/jlb.0503205  1
2003 Suryadevara R, Holter S, Borgmann K, Persidsky R, Labenz-Zink C, Persidsky Y, Gendelman HE, Wu L, Ghorpade A. Regulation of tissue inhibitor of metalloproteinase-1 by astrocytes: links to HIV-1 dementia. Glia. 44: 47-56. PMID 12951656 DOI: 10.1002/glia.10266  1
2003 Anderson ER, Boyle J, Zink WE, Persidsky Y, Gendelman HE, Xiong H. Hippocampal synaptic dysfunction in a murine model of human immunodeficiency virus type 1 encephalitis. Neuroscience. 118: 359-69. PMID 12699772 DOI: 10.1016/S0306-4522(02)00925-9  1
2003 Xiong H, Boyle J, Winkelbauer M, Gorantla S, Zheng J, Ghorpade A, Persidsky Y, Carlson KA, Gendelman HE. Inhibition of long-term potentiation by interleukin-8: implications for human immunodeficiency virus-1-associated dementia. Journal of Neuroscience Research. 71: 600-7. PMID 12548717 DOI: 10.1002/jnr.10503  1
2002 Persidsky Y, Gendelman HE. Murine models for human immunodeficiency virus type 1-associated dementia: the development of new treatment testing paradigms. Journal of Neurovirology. 8: 49-52. PMID 12491151 DOI: 10.1080/13550280290167993  1
2002 Poluektova LY, Munn DH, Persidsky Y, Gendelman HE. Generation of cytotoxic T cells against virus-infected human brain macrophages in a murine model of HIV-1 encephalitis. Journal of Immunology (Baltimore, Md. : 1950). 168: 3941-9. PMID 11937550  1
2002 Zink WE, Anderson E, Boyle J, Hock L, Rodriguez-Sierra J, Xiong H, Gendelman HE, Persidsky Y. Impaired spatial cognition and synaptic potentiation in a murine model of human immunodeficiency virus type 1 encephalitis. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 22: 2096-105. PMID 11896149  1
2001 Zheng J, Thylin MR, Persidsky Y, Williams CE, Cotter RL, Zink W, Ryan L, Ghorpade A, Lewis K, Gendelman HE. HIV-1 infected immune competent mononuclear phagocytes influence the pathways to neuronal demise. Neurotoxicity Research. 3: 461-84. PMID 14715459  1
2001 Zheng J, Thylin MR, Cotter RL, Lopez AL, Ghorpade A, Persidsky Y, Xiong H, Leisman GB, Che MH, Gendelman HE. HIV-1 infected and immune competent mononuclear phagocytes induce quantitative alterations in neuronal dendritic arbor: relevance for HIV-1-associated dementia. Neurotoxicity Research. 3: 443-59. PMID 14715458  1
2001 Zink WE, Boyle J, Persidsky Y, Xiong H, Gendelman HE. Model systems for assessing cognitive function: implications for HIV-1 infection and drugs of abuse. Advances in Experimental Medicine and Biology. 493: 7-27. PMID 11727783 DOI: 10.1007/0-306-47611-8_2  1
2001 Poluektova L, Moran T, Zelivyanskaya M, Swindells S, Gendelman HE, Persidsky Y. The regulation of alpha chemokines during HIV-1 infection and leukocyte activation: relevance for HIV-1-associated dementia. Journal of Neuroimmunology. 120: 112-28. PMID 11694326 DOI: 10.1016/S0165-5728(01)00413-1  1
2001 Ghorpade A, Persidskaia R, Suryadevara R, Che M, Liu XJ, Persidsky Y, Gendelman HE. Mononuclear phagocyte differentiation, activation, and viral infection regulate matrix metalloproteinase expression: implications for human immunodeficiency virus type 1-associated dementia. Journal of Virology. 75: 6572-83. PMID 11413325 DOI: 10.1128/JVI.75.14.6572-6583.2001  1
2001 Persidsky Y, Limoges J. HIV-1 infection: new treatment paradigms. European Journal of Clinical Investigation. 31: 190-2. PMID 11264644 DOI: 10.1046/j.1365-2362.2001.00805.x  1
2001 Persidsky Y, Limoges J, Rasmussen J, Zheng J, Gearing A, Gendelman HE. Reduction in glial immunity and neuropathology by a PAF antagonist and an MMP and TNFalpha inhibitor in SCID mice with HIV-1 encephalitis. Journal of Neuroimmunology. 114: 57-68. PMID 11240016 DOI: 10.1016/S0165-5728(00)00454-9  1
2001 Limoges J, Poluektova L, Ratanasuwan W, Rasmussen J, Zelivyanskaya M, McClernon DR, Lanier ER, Gendelman HE, Persidsky Y. The efficacy of potent anti-retroviral drug combinations tested in a murine model of HIV-1 encephalitis. Virology. 281: 21-34. PMID 11222092 DOI: 10.1006/viro.2000.0758  1
2000 Persidsky Y, Zheng J, Miller D, Gendelman HE. Mononuclear phagocytes mediate blood-brain barrier compromise and neuronal injury during HIV-1-associated dementia. Journal of Leukocyte Biology. 68: 413-22. PMID 10985259  1
2000 Xiong H, Zeng YC, Lewis T, Zheng J, Persidsky Y, Gendelman HE. HIV-1 infected mononuclear phagocyte secretory products affect neuronal physiology leading to cellular demise: relevance for HIV-1-associated dementia. Journal of Neurovirology. 6: S14-23. PMID 10871761  1
2000 Limoges J, Persidsky Y, Poluektova L, Rasmussen J, Ratanasuwan W, Zelivyanskaya M, McClernon DR, Lanier ER, Gendelman HE. Evaluation of antiretroviral drug efficacy for HIV-1 encephalitis in SCID mice. Neurology. 54: 379-89. PMID 10668699  1
1999 Persidsky Y. Model systems for studies of leukocyte migration across the blood - brain barrier. Journal of Neurovirology. 5: 579-90. PMID 10602399  1
1999 Zink WE, Zheng J, Persidsky Y, Poluektova L, Gendelman HE. The neuropathogenesis of HIV-1 infection. Fems Immunology and Medical Microbiology. 26: 233-41. PMID 10575134 DOI: 10.1016/S0928-8244(99)00152-2  1
1999 Persidsky Y, Ghorpade A, Rasmussen J, Limoges J, Liu XJ, Stins M, Fiala M, Way D, Kim KS, Witte MH, Weinand M, Carhart L, Gendelman HE. Microglial and astrocyte chemokines regulate monocyte migration through the blood-brain barrier in human immunodeficiency virus-1 encephalitis. The American Journal of Pathology. 155: 1599-611. PMID 10550317 DOI: 10.1016/S0002-9440(10)65476-4  1
1999 Zheng J, Thylin MR, Ghorpade A, Xiong H, Persidsky Y, Cotter R, Niemann D, Che M, Zeng YC, Gelbard HA, Shepard RB, Swartz JM, Gendelman HE. Intracellular CXCR4 signaling, neuronal apoptosis and neuropathogenic mechanisms of HIV-1-associated dementia. Journal of Neuroimmunology. 98: 185-200. PMID 10430052 DOI: 10.1016/S0165-5728(99)00049-1  1
1998 Gendelman HE, Zheng J, Coulter CL, Ghorpade A, Che M, Thylin M, Rubocki R, Persidsky Y, Hahn F, Reinhard J, Swindells S. Suppression of inflammatory neurotoxins by highly active antiretroviral therapy in human immunodeficiency virus-associated dementia. The Journal of Infectious Diseases. 178: 1000-7. PMID 9806027  1
1998 Davis V, Persidskaia R, Baca-Regen L, Itoh Y, Nagase H, Persidsky Y, Ghorpade A, Baxter BT. Matrix metalloproteinase-2 production and its binding to the matrix are increased in abdominal aortic aneurysms. Arteriosclerosis, Thrombosis, and Vascular Biology. 18: 1625-33. PMID 9763536  1
1998 Grange JJ, Baca-Regen LM, Nollendorfs AJ, Persidsky Y, Sudan DL, Baxter BT. Protein kinase C isoforms in human aortic smooth muscle cells. Journal of Vascular Surgery. 27: 919-26; discussion 9. PMID 9620145  1
1998 Avgeropoulos N, Kelley B, Middaugh L, Arrigo S, Persidsky Y, Gendelman HE, Tyor WR. SCID mice with HIV encephalitis develop behavioral abnormalities. Journal of Acquired Immune Deficiency Syndromes and Human Retrovirology : Official Publication of the International Retrovirology Association. 18: 13-20. PMID 9593453  1
1998 Ghorpade A, Xia MQ, Hyman BT, Persidsky Y, Nukuna A, Bock P, Che M, Limoges J, Gendelman HE, Mackay CR. Role of the beta-chemokine receptors CCR3 and CCR5 in human immunodeficiency virus type 1 infection of monocytes and microglia. Journal of Virology. 72: 3351-61. PMID 9525662  1
1998 Ghorpade A, Nukuna A, Che M, Haggerty S, Persidsky Y, Carter E, Carhart L, Shafer L, Gendelman HE. Human immunodeficiency virus neurotropism: an analysis of viral replication and cytopathicity for divergent strains in monocytes and microglia. Journal of Virology. 72: 3340-50. PMID 9525661  1
1997 Persidsky Y, Buttini M, Limoges J, Bock P, Gendelman HE. An analysis of HIV-1-associated inflammatory products in brain tissue of humans and SCID mice with HIV-1 encephalitis. Journal of Neurovirology. 3: 401-16. PMID 9475112  1
1997 Gendelman HE, Persidsky Y, Ghorpade A, Limoges J, Stins M, Fiala M, Morrisett R. The neuropathogenesis of the AIDS dementia complex. Aids (London, England). 11: S35-45. PMID 9451964  1
1997 Persidsky Y, Gendelman HE. Development of laboratory and animal model systems for HIV-1 encephalitis and its associated dementia. Journal of Leukocyte Biology. 62: 100-6. PMID 9226000  1
1997 Limoges J, Persidsky Y, Bock P, Gendelman HE. Dexamethasone therapy worsens the neuropathology of human immunodeficiency virus type 1 encephalitis in SCID mice. The Journal of Infectious Diseases. 175: 1368-81. PMID 9180176  1
1997 Persidsky Y, Stins M, Way D, Witte MH, Weinand M, Kim KS, Bock P, Gendelman HE, Fiala M. A model for monocyte migration through the blood-brain barrier during HIV-1 encephalitis. Journal of Immunology (Baltimore, Md. : 1950). 158: 3499-510. PMID 9120312  1
1997 Gendelman HE, Zheng J, Ghorpade A, Rubocki R, Persidsky Y, Coulter C, Hahn FJ, Swindells S. HIV-1 dementia: A metabolic encephalopathy abrogated by highly active antiretroviral therapy (HAART) Clinical Infectious Diseases. 25: 457.  1
1996 Persidsky Y, Limoges J, McComb R, Bock P, Baldwin T, Tyor W, Patil A, Nottet HS, Epstein L, Gelbard H, Flanagan E, Reinhard J, Pirruccello SJ, Gendelman HE. Human immunodeficiency virus encephalitis in SCID mice. The American Journal of Pathology. 149: 1027-53. PMID 8780406  1
1996 Nottet HS, Persidsky Y, Sasseville VG, Nukuna AN, Bock P, Zhai QH, Sharer LR, McComb RD, Swindells S, Soderland C, Gendelman HE. Mechanisms for the transendothelial migration of HIV-1-infected monocytes into brain. Journal of Immunology (Baltimore, Md. : 1950). 156: 1284-95. PMID 8558009  1
1995 Persidsky Y, Nottet HS, Sasseville VG, Epstein LG, Gendelman HE. The development of animal model systems for HIV-1 encephalitis and its associated dementia. Journal of Neurovirology. 1: 229-43. PMID 9222361  1
1995 Persidsky Y, Steffan AM, Gendrault JL, Royer C, Aubertin AM, Kirn A. Morpho-functional changes of follicular dendritic cells (FDC) and lymph node structure in simian immunodeficiency virus (SIV) infection. Advances in Experimental Medicine and Biology. 378: 329-31. PMID 8526085  1
1995 Nottet HS, Jett M, Flanagan CR, Zhai QH, Persidsky Y, Rizzino A, Bernton EW, Genis P, Baldwin T, Schwartz J. A regulatory role for astrocytes in HIV-1 encephalitis. An overexpression of eicosanoids, platelet-activating factor, and tumor necrosis factor-alpha by activated HIV-1-infected monocytes is attenuated by primary human astrocytes. Journal of Immunology (Baltimore, Md. : 1950). 154: 3567-81. PMID 7897236  1
1995 Persidsky Y, Steffan AM, Gendrault JL, Hurtrel B, Berger S, Royer C, Stutte HJ, Muchmore E, Aubertin AM, Kirn A. Permissiveness of Kupffer cells for simian immunodeficiency virus (SIV) and morphological changes in the liver of rhesus monkeys at different periods of SIV infection. Hepatology (Baltimore, Md.). 21: 1215-25. PMID 7737626 DOI: 10.1016/0270-9139(95)90040-3  1
1995 Persidsky Y, Liska V, Huss T, Gendrault JL, Venet A, Muchmore E, Traincard F, Kirn A, Aubertin AM. Presence of virion protein x (Vpx) of simian immunodeficiency virus SIVmac 251 in target cells in vivo. Journal of Medical Primatology. 24: 35-42. PMID 7563009  1
1995 Persidsky Y, Steffan AM, Gendrault JL, Royer C, Beyer C, Muchmore E, Kirn A, Aubertin AM. Morphological changes in lymph nodes and expression of VCAM1 and cytokines at the late stages of SIV-induced disease in rhesus monkeys. Research in Virology. 146: 185-200. PMID 7481091 DOI: 10.1016/0923-2516(96)80579-6  1
1994 Persidsky Y, Berger S, Gendrault JL, Steffan AM, Royer C, Hurtrel B, Stutte HJ, Kirn A, Aubertin AM. Signs of Kupffer cell involvement in productive simian immunodeficiency virus infection in monkey liver. Research in Virology. 145: 229-37. PMID 7800950 DOI: 10.1016/S0923-2516(07)80027-6  1
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