Pedro Gonzalez-Alegre, M.D. - Publications

Affiliations: 
University of Iowa, Iowa City, IA 

52 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2018 Maguire JA, Gagne AL, Gonzalez-Alegre P, Davidson BL, Shakkottai V, Gadue P, French DL. Generation of Spinocerebellar Ataxia Type 2 induced pluripotent stem cell lines, CHOPi002-A and CHOPi003-A, from patients with abnormal CAG repeats in the coding region of the ATXN2 gene. Stem Cell Research. 34: 101361. PMID 30611021 DOI: 10.1016/j.scr.2018.101361  0.32
2016 Beauvais G, Bode NM, Watson JL, Wen H, Glenn KA, Kawano H, Harata NC, Ehrlich ME, Gonzalez-Alegre P. Disruption of Protein Processing in the Endoplasmic Reticulum of DYT1 Knock-in Mice Implicates Novel Pathways in Dystonia Pathogenesis. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 36: 10245-10256. PMID 27707963 DOI: 10.1523/JNEUROSCI.0669-16.2016  0.36
2016 Keiser MS, Monteys AM, Corbau R, Gonzalez-Alegre P, Davidson BL. RNAi prevents and reverses phenotypes induced by mutant human ataxin-1. Annals of Neurology. PMID 27686464 DOI: 10.1002/ana.24789  0.32
2015 Keiser MS, Kordower JH, Gonzalez-Alegre P, Davidson BL. Broad distribution of ataxin 1 silencing in rhesus cerebella for spinocerebellar ataxia type 1 therapy. Brain : a Journal of Neurology. PMID 26490326 DOI: 10.1093/brain/awv292  1
2015 Tereshchenko A, McHugh M, Lee JK, Gonzalez-Alegre P, Crane K, Dawson J, Nopoulos P. Abnormal Weight and Body Mass Index in Children with Juvenile Huntington's Disease. Journal of Huntington's Disease. PMID 26443925 DOI: 10.3233/JHD-150152  1
2015 Ruiz M, Perez-Garcia G, Ortiz-Virumbrales M, Méneret A, Morant A, Kottwitz J, Fuchs T, Bonet J, Gonzalez-Alegre P, Hof PR, Ozelius LJ, Ehrlich ME. Abnormalities of motor function, transcription and cerebellar structure in mouse models of THAP1 dystonia. Human Molecular Genetics. PMID 26376866 DOI: 10.1093/hmg/ddv384  1
2015 Edwards C, Leira EC, Gonzalez-Alegre P. Residency training: a failed lumbar puncture is more about obesity than lack of ability. Neurology. 84: e69-72. PMID 25754807 DOI: 10.1212/WNL.0000000000001335  1
2014 García-Casares N, Jorge RE, García-Arnés JA, Acion L, Berthier ML, Gonzalez-Alegre P, Nabrozidis A, Gutiérrez A, Ariza MJ, Rioja J, González-Santos P. Cognitive dysfunctions in middle-aged type 2 diabetic patients and neuroimaging correlations: a cross-sectional study. Journal of Alzheimer's Disease : Jad. 42: 1337-46. PMID 25024335 DOI: 10.3233/JAD-140702  1
2014 García-Casares N, Berthier ML, Jorge RE, Gonzalez-Alegre P, Gutiérrez Cardo A, Rioja Villodres J, Acion L, Ariza Corbo MJ, Nabrozidis A, García-Arnés JA, González-Santos P. Structural and functional brain changes in middle-aged type 2 diabetic patients: a cross-sectional study. Journal of Alzheimer's Disease : Jad. 40: 375-86. PMID 24448784 DOI: 10.3233/JAD-131736  1
2014 Lamichhane D, Narayanan NS, Gonzalez-Alegre P. Two cases of pregnancy in Parkinson's disease. Parkinsonism & Related Disorders. 20: 239-40. PMID 24182521 DOI: 10.1016/j.parkreldis.2013.10.013  1
2014 Noetzli L, Sanz PG, Brodsky GL, Hinckley JD, Giugni JC, Giannaula RJ, Gonzalez-Alegre P, Di Paola J. A novel mutation in PLP1 causes severe hereditary spastic paraplegia type 2. Gene. 533: 447-50. PMID 24103481 DOI: 10.1016/j.gene.2013.09.076  1
2013 Paemka L, Mahajan VB, Skeie JM, Sowers LP, Ehaideb SN, Gonzalez-Alegre P, Sasaoka T, Tao H, Miyagi A, Ueno N, Takao K, Miyakawa T, Wu S, Darbro BW, Ferguson PJ, et al. PRICKLE1 interaction with SYNAPSIN I reveals a role in autism spectrum disorders. Plos One. 8: e80737. PMID 24312498 DOI: 10.1371/journal.pone.0080737  1
2013 Gonzalez-Alegre P, Buffard V, Wang K, Henien S, Morcuende JA. Exploring the link between dystonia genes and idiopathic scoliosis. Journal of Pediatric Orthopedics. 33: e65-6. PMID 23812140 DOI: 10.1097/BPO.0b013e31829aac15  1
2013 Letort D, Gonzalez-Alegre P. Huntington's disease in children. Handbook of Clinical Neurology. 113: 1913-7. PMID 23622414 DOI: 10.1016/B978-0-444-59565-2.00061-7  1
2012 Gordon KL, Glenn KA, Bode N, Wen HM, Paulson HL, Gonzalez-Alegre P. The ubiquitin ligase F-box/G-domain protein 1 promotes the degradation of the disease-linked protein torsinA through the ubiquitin-proteasome pathway and macroautophagy. Neuroscience. 224: 160-71. PMID 22917612 DOI: 10.1016/j.neuroscience.2012.08.023  1
2012 Bode N, Massey C, Gonzalez-Alegre P. DYT1 knock-in mice are not sensitized against mitochondrial complex-II inhibition. Plos One. 7: e42644. PMID 22880064 DOI: 10.1371/journal.pone.0042644  1
2012 Beglinger LJ, Prest L, Mills JA, Paulsen JS, Smith MM, Gonzalez-Alegre P, Rowe KC, Nopoulos P, Uc EY. Clinical predictors of driving status in Huntington's disease. Movement Disorders : Official Journal of the Movement Disorder Society. 27: 1146-52. PMID 22744778 DOI: 10.1002/mds.25101  1
2012 Kakazu Y, Koh JY, Iwabuchi S, Gonzalez-Alegre P, Harata NC. Miniature release events of glutamate from hippocampal neurons are influenced by the dystonia-associated protein torsinA. Synapse (New York, N.Y.). 66: 807-22. PMID 22588999 DOI: 10.1002/syn.21571  1
2012 Byars JA, Beglinger LJ, Moser DJ, Gonzalez-Alegre P, Nopoulos P. Substance abuse may be a risk factor for earlier onset of Huntington disease. Journal of Neurology. 259: 1824-31. PMID 22274789 DOI: 10.1007/s00415-012-6415-8  1
2012 Kakazu Y, Koh JY, Ho KW, Gonzalez-Alegre P, Harata NC. Synaptic vesicle recycling is enhanced by torsinA that harbors the DYT1 dystonia mutation. Synapse (New York, N.Y.). 66: 453-64. PMID 22213465 DOI: 10.1002/syn.21534  1
2011 Strader S, Rodnitzky RL, Gonzalez-Alegre P. Secondary dystonia in a botulinum toxin clinic: clinical characteristics, neuroanatomical substrate and comparison with idiopathic dystonia. Parkinsonism & Related Disorders. 17: 749-52. PMID 21852177 DOI: 10.1016/j.parkreldis.2011.07.013  1
2011 Maric M, Shao J, Ryan RJ, Wong CS, Gonzalez-Alegre P, Roller RJ. A functional role for TorsinA in herpes simplex virus 1 nuclear egress. Journal of Virology. 85: 9667-79. PMID 21775450 DOI: 10.1128/JVI.05314-11  1
2011 Martin JN, Wolken N, Brown T, Dauer WT, Ehrlich ME, Gonzalez-Alegre P. Lethal toxicity caused by expression of shRNA in the mouse striatum: implications for therapeutic design. Gene Therapy. 18: 666-73. PMID 21368900 DOI: 10.1038/gt.2011.10  1
2011 Gordon KL, Glenn KA, Gonzalez-Alegre P. Exploring the influence of torsinA expression on protein quality control. Neurochemical Research. 36: 452-9. PMID 21161590 DOI: 10.1007/s11064-010-0363-4  1
2010 Wen H, Kim N, Fuentes EJ, Mallinger A, Gonzalez-Alegre P, Glenn KA. FBG1 is a promiscuous ubiquitin ligase that sequesters APC2 and causes S-phase arrest. Cell Cycle (Georgetown, Tex.). 9: 4506-17. PMID 21135578 DOI: 10.4161/cc.9.22.13743  1
2010 Harris GM, Dodelzon K, Gong L, Gonzalez-Alegre P, Paulson HL. Splice isoforms of the polyglutamine disease protein ataxin-3 exhibit similar enzymatic yet different aggregation properties. Plos One. 5: e13695. PMID 21060878 DOI: 10.1371/journal.pone.0013695  1
2010 Page ME, Bao L, Andre P, Pelta-Heller J, Sluzas E, Gonzalez-Alegre P, Bogush A, Khan LE, Iacovitti L, Rice ME, Ehrlich ME. Cell-autonomous alteration of dopaminergic transmission by wild type and mutant (DeltaE) TorsinA in transgenic mice. Neurobiology of Disease. 39: 318-26. PMID 20460154 DOI: 10.1016/j.nbd.2010.04.016  1
2010 Gonzalez-Alegre P. Descriptions of cervical dystonia by Sir Charles Bell. Movement Disorders : Official Journal of the Movement Disorder Society. 25: 257-9. PMID 20131384 DOI: 10.1002/mds.23003  1
2009 Martin JN, Bair TB, Bode N, Dauer WT, Gonzalez-Alegre P. Transcriptional and proteomic profiling in a cellular model of DYT1 dystonia. Neuroscience. 164: 563-72. PMID 19665049 DOI: 10.1016/j.neuroscience.2009.07.068  1
2009 Harlow TL, Gonzalez-Alegre P. High prevalence of reported tremor in Klinefelter syndrome. Parkinsonism & Related Disorders. 15: 393-5. PMID 18977683 DOI: 10.1016/j.parkreldis.2008.08.009  1
2008 Jinnah H, Richter A, Mink JW, Caldwell GA, Caldwell KA, Gonzalez-Alegre P, Cookson MR, Breakefield XO, Delong MR, Hess EJ. Animal models for drug discovery in dystonia. Expert Opinion On Drug Discovery. 3: 83-97. PMID 23480141 DOI: 10.1517/17460441.3.1.83  1
2008 Bassuk AG, Wallace RH, Buhr A, Buller AR, Afawi Z, Shimojo M, Miyata S, Chen S, Gonzalez-Alegre P, Griesbach HL, Wu S, Nashelsky M, Vladar EK, Antic D, Ferguson PJ, et al. A homozygous mutation in human PRICKLE1 causes an autosomal-recessive progressive myoclonus epilepsy-ataxia syndrome. American Journal of Human Genetics. 83: 572-81. PMID 18976727 DOI: 10.1016/j.ajhg.2008.10.003  1
2008 Gordon KL, Gonzalez-Alegre P. Consequences of the DYT1 mutation on torsinA oligomerization and degradation. Neuroscience. 157: 588-95. PMID 18940237 DOI: 10.1016/j.neuroscience.2008.09.028  1
2008 Harlow TL, Rodnitzky RL, Gonzalez-Alegre P. From essential tremor to Klinefelter through Fragile X, an unexpected journey. Movement Disorders : Official Journal of the Movement Disorder Society. 23: 1328-9. PMID 18464279 DOI: 10.1002/mds.22033  1
2008 Harper SQ, Gonzalez-Alegre P. Lentivirus-mediated RNA interference in mammalian neurons. Methods in Molecular Biology (Clifton, N.J.). 442: 95-112. PMID 18369781 DOI: 10.1007/978-1-59745-191-8_8  1
2007 Gonzalez-Alegre P, Paulson HL. Technology insight: therapeutic RNA interference--how far from the neurology clinic? Nature Clinical Practice. Neurology. 3: 394-404. PMID 17611488 DOI: 10.1038/ncpneuro0551  1
2007 Gonzalez-Alegre P. The inherited dystonias. Seminars in Neurology. 27: 151-8. PMID 17390260 DOI: 10.1055/s-2007-971170  1
2007 Gonzalez-Alegre P. Therapeutic RNA interference for neurodegenerative diseases: From promise to progress. Pharmacology & Therapeutics. 114: 34-55. PMID 17316816 DOI: 10.1016/j.pharmthera.2007.01.003  1
2007 Gonzalez-Alegre P. Monomelic parkinsonian tremor caused by contralateral substantia nigra stroke. Parkinsonism & Related Disorders. 13: 182-4. PMID 16731026 DOI: 10.1016/j.parkreldis.2006.03.011  1
2006 Paulson H, Gonzalez-Alegre P. RNAi gets its prize. The Lancet. Neurology. 5: 997-9. PMID 17110276 DOI: 10.1016/S1474-4422(06)70609-3  1
2006 Gonzalez-Alegre P, Afifi AK. Clinical characteristics of childhood-onset (juvenile) Huntington disease: report of 12 patients and review of the literature. Journal of Child Neurology. 21: 223-9. PMID 16901424 DOI: 10.2310/7010.2006.00055  1
2006 Gonzalez-Alegre P, Kelkar P, Rodnitzky RL. Isolated high-frequency jaw tremor relieved by botulinum toxin injections. Movement Disorders : Official Journal of the Movement Disorder Society. 21: 1049-50. PMID 16602105 DOI: 10.1002/mds.20878  1
2006 Jinnah HA, Visser JE, Harris JC, Verdu A, Larovere L, Ceballos-Picot I, Gonzalez-Alegre P, Neychev V, Torres RJ, Dulac O, Desguerre I, Schretlen DJ, Robey KL, Barabas G, Bloem BR, et al. Delineation of the motor disorder of Lesch-Nyhan disease. Brain : a Journal of Neurology. 129: 1201-17. PMID 16549399 DOI: 10.1093/brain/awl056  1
2006 Rodriguez-Lebron E, Gonzalez-Alegre P. Silencing neurodegenerative disease: bringing RNA interference to the clinic. Expert Review of Neurotherapeutics. 6: 223-33. PMID 16466302 DOI: 10.1586/14737175.6.2.223  1
2005 Miller VM, Paulson HL, Gonzalez-Alegre P. RNA interference in neuroscience: progress and challenges. Cellular and Molecular Neurobiology. 25: 1195-207. PMID 16388332 DOI: 10.1007/s10571-005-8447-4  1
2005 Gonzalez-Alegre P, Bode N, Davidson BL, Paulson HL. Silencing primary dystonia: lentiviral-mediated RNA interference therapy for DYT1 dystonia. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 25: 10502-9. PMID 16280588 DOI: 10.1523/JNEUROSCI.3016-05.2005  1
2004 Gonzalez-Alegre P, Paulson HL. Aberrant cellular behavior of mutant torsinA implicates nuclear envelope dysfunction in DYT1 dystonia. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 24: 2593-601. PMID 15028751 DOI: 10.1523/JNEUROSCI.4461-03.2004  1
2003 Gonzalez-Alegre P, Ammache Z, Davis PH, Rodnitzky RL. Moyamoya-induced paroxysmal dyskinesia. Movement Disorders : Official Journal of the Movement Disorder Society. 18: 1051-6. PMID 14502675 DOI: 10.1002/mds.10483  1
2003 Gonzalez-Alegre P, Tippin J. Prolonged cortical electrical depression and diffuse vasospasm without ischemia in a case of severe hemiplegic migraine during pregnancy. Headache. 43: 72-5. PMID 12864763 DOI: 10.1046/j.1526-4610.2003.03014.x  1
2003 Gonzalez-Alegre P, Miller VM, Davidson BL, Paulson HL. Toward therapy for DYT1 dystonia: allele-specific silencing of mutant TorsinA. Annals of Neurology. 53: 781-7. PMID 12783425 DOI: 10.1002/ana.10548  1
2002 Gonzalez-Alegre P, Recober A, Kelkar P. Idiopathic brachial neuritis. The Iowa Orthopaedic Journal. 22: 81-5. PMID 12180618  1
2001 Gonzalez-Alegre P, Ruiz-Lopez AD, Abarca-Costalago M, Gonzalez-Santos P. Increment of the platelet count in temporal arteritis: response to therapy and ischemic complications. European Neurology. 45: 43-5. PMID 11150840 DOI: 10.1159/000052088  1
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