| Year |
Citation |
Score |
| 2020 |
Robbins NM, Ozmore JR, Winder TL, Gonzalez-Alegre P, Bardakjian TM. A Novel SPAST/SPG4 Splice-Site Variant in a Family with Dominant Hereditary Spastic Paraplegia. Case Reports in Neurological Medicine. 2020: 7219514. PMID 32908740 DOI: 10.1155/2020/7219514 |
0.307 |
|
| 2019 |
Gonzalez-Alegre P, Beauvais G, Martin J, Koch RJ, Walker RH, Patel JC, Rice ME, Ehrlich ME. A novel transgenic mouse model to investigate the cell-autonomous effects of torsinA(ΔE) expression in striatal output neurons. Neuroscience. PMID 31669362 DOI: 10.1016/J.Neuroscience.2019.09.007 |
0.571 |
|
| 2019 |
Hitti FL, Yang AI, Gonzalez-Alegre P, Baltuch GH. Human gene therapy approaches for the treatment of Parkinson's disease: An overview of current and completed clinical trials. Parkinsonism & Related Disorders. PMID 31324556 DOI: 10.1016/J.Parkreldis.2019.07.018 |
0.3 |
|
| 2019 |
Gonzalez-Alegre P. Advances in molecular and cell biology of dystonia: Focus on torsinA. Neurobiology of Disease. 127: 233-241. PMID 30877032 DOI: 10.1016/J.Nbd.2019.03.007 |
0.396 |
|
| 2018 |
Maguire JA, Gagne AL, Gonzalez-Alegre P, Davidson BL, Shakkottai V, Gadue P, French DL. Generation of Spinocerebellar Ataxia Type 2 induced pluripotent stem cell lines, CHOPi002-A and CHOPi003-A, from patients with abnormal CAG repeats in the coding region of the ATXN2 gene. Stem Cell Research. 34: 101361. PMID 30611021 DOI: 10.1016/J.Scr.2018.101361 |
0.315 |
|
| 2018 |
Beauvais G, Watson JL, Aguirre JA, Tecedor L, Ehrlich ME, Gonzalez-Alegre P. Efficient RNA interference-based knockdown of mutant torsinA reveals reversibility of PERK-eIF2α pathway dysregulation in DYT1 transgenic rats in vivo. Brain Research. PMID 30366018 DOI: 10.1016/J.Brainres.2018.10.025 |
0.319 |
|
| 2018 |
Hitti FL, Gonzalez-Alegre P, Lucas TH. Gene Therapy for Neurological Disease: A Neurosurgical Review. World Neurosurgery. PMID 30253990 DOI: 10.1016/J.Wneu.2018.09.097 |
0.303 |
|
| 2018 |
Zakirova Z, Fanutza T, Bonet J, Readhead B, Zhang W, Yi Z, Beauvais G, Zwaka TP, Ozelius LJ, Blitzer RD, Gonzalez-Alegre P, Ehrlich ME. Mutations in THAP1/DYT6 reveal that diverse dystonia genes disrupt similar neuronal pathways and functions. Plos Genetics. 14: e1007169. PMID 29364887 DOI: 10.1371/Journal.Pgen.1007169 |
0.401 |
|
| 2017 |
Mendizabal A, Ngo Vu AT, Thibault D, Gonzalez-Alegre P, Willis A. Hospitalizations of Children with Huntington's Disease in the United States. Movement Disorders Clinical Practice. 4: 682-688. PMID 30363491 DOI: 10.1002/Mdc3.12506 |
0.322 |
|
| 2017 |
Beauvais G, Rodriguez-Losada N, Ying L, Zakirova Z, Watson JL, Readhead B, Gadue P, French DL, Ehrlich ME, Gonzalez-Alegre P. Exploring the Interaction Between eIF2α Dysregulation, Acute Endoplasmic Reticulum Stress and DYT1 Dystonia in the Mammalian Brain. Neuroscience. PMID 29289717 DOI: 10.1016/J.Neuroscience.2017.12.033 |
0.366 |
|
| 2017 |
Aguilo F, Zakirova Z, Nolan K, Wagner R, Sharma R, Hogan M, Wei C, Sun Y, Walsh MJ, Kelley K, Zhang W, Ozelius LJ, Gonzalez-Alegre P, Zwaka TP, Ehrlich ME. THAP1: Role in Mouse Embryonic Stem Cell Survival and Differentiation. Stem Cell Reports. PMID 28579396 DOI: 10.1016/J.Stemcr.2017.04.032 |
0.394 |
|
| 2016 |
Beauvais G, Bode NM, Watson JL, Wen H, Glenn KA, Kawano H, Harata NC, Ehrlich ME, Gonzalez-Alegre P. Disruption of Protein Processing in the Endoplasmic Reticulum of DYT1 Knock-in Mice Implicates Novel Pathways in Dystonia Pathogenesis. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 36: 10245-10256. PMID 27707963 DOI: 10.1523/Jneurosci.0669-16.2016 |
0.428 |
|
| 2016 |
Klionsky DJ, Abdelmohsen K, Abe A, Abedin MJ, Abeliovich H, Acevedo Arozena A, Adachi H, Adams CM, Adams PD, Adeli K, Adhihetty PJ, Adler SG, Agam G, Agarwal R, Aghi MK, ... ... Gonzalez-Alegre P, et al. Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition). Autophagy. 12: 1-222. PMID 26799652 DOI: 10.1080/15548627.2015.1100356 |
0.333 |
|
| 2015 |
Keiser MS, Kordower JH, Gonzalez-Alegre P, Davidson BL. Broad distribution of ataxin 1 silencing in rhesus cerebella for spinocerebellar ataxia type 1 therapy. Brain : a Journal of Neurology. PMID 26490326 DOI: 10.1093/Brain/Awv292 |
0.374 |
|
| 2015 |
Ruiz M, Perez-Garcia G, Ortiz-Virumbrales M, Méneret A, Morant A, Kottwitz J, Fuchs T, Bonet J, Gonzalez-Alegre P, Hof PR, Ozelius LJ, Ehrlich ME. Abnormalities of motor function, transcription and cerebellar structure in mouse models of THAP1 dystonia. Human Molecular Genetics. PMID 26376866 DOI: 10.1093/Hmg/Ddv384 |
0.391 |
|
| 2014 |
Noetzli L, Sanz PG, Brodsky GL, Hinckley JD, Giugni JC, Giannaula RJ, Gonzalez-Alegre P, Di Paola J. A novel mutation in PLP1 causes severe hereditary spastic paraplegia type 2. Gene. 533: 447-50. PMID 24103481 DOI: 10.1016/J.Gene.2013.09.076 |
0.398 |
|
| 2013 |
Paemka L, Mahajan VB, Skeie JM, Sowers LP, Ehaideb SN, Gonzalez-Alegre P, Sasaoka T, Tao H, Miyagi A, Ueno N, Takao K, Miyakawa T, Wu S, Darbro BW, Ferguson PJ, et al. PRICKLE1 interaction with SYNAPSIN I reveals a role in autism spectrum disorders. Plos One. 8: e80737. PMID 24312498 DOI: 10.1371/Journal.Pone.0080737 |
0.367 |
|
| 2013 |
Gonzalez-Alegre P, Buffard V, Wang K, Henien S, Morcuende JA. Exploring the link between dystonia genes and idiopathic scoliosis. Journal of Pediatric Orthopedics. 33: e65-6. PMID 23812140 DOI: 10.1097/Bpo.0B013E31829Aac15 |
0.355 |
|
| 2013 |
Letort D, Gonzalez-Alegre P. Huntington's disease in children. Handbook of Clinical Neurology. 113: 1913-7. PMID 23622414 DOI: 10.1016/B978-0-444-59565-2.00061-7 |
0.343 |
|
| 2012 |
Gordon KL, Glenn KA, Bode N, Wen HM, Paulson HL, Gonzalez-Alegre P. The ubiquitin ligase F-box/G-domain protein 1 promotes the degradation of the disease-linked protein torsinA through the ubiquitin-proteasome pathway and macroautophagy. Neuroscience. 224: 160-71. PMID 22917612 DOI: 10.1016/J.Neuroscience.2012.08.023 |
0.666 |
|
| 2012 |
Bode N, Massey C, Gonzalez-Alegre P. DYT1 knock-in mice are not sensitized against mitochondrial complex-II inhibition. Plos One. 7: e42644. PMID 22880064 DOI: 10.1371/Journal.Pone.0042644 |
0.37 |
|
| 2012 |
Kakazu Y, Koh JY, Iwabuchi S, Gonzalez-Alegre P, Harata NC. Miniature release events of glutamate from hippocampal neurons are influenced by the dystonia-associated protein torsinA. Synapse (New York, N.Y.). 66: 807-22. PMID 22588999 DOI: 10.1002/Syn.21571 |
0.344 |
|
| 2012 |
Kakazu Y, Koh JY, Ho KW, Gonzalez-Alegre P, Harata NC. Synaptic vesicle recycling is enhanced by torsinA that harbors the DYT1 dystonia mutation. Synapse (New York, N.Y.). 66: 453-64. PMID 22213465 DOI: 10.1002/Syn.21534 |
0.313 |
|
| 2011 |
Martin JN, Wolken N, Brown T, Dauer WT, Ehrlich ME, Gonzalez-Alegre P. Lethal toxicity caused by expression of shRNA in the mouse striatum: implications for therapeutic design. Gene Therapy. 18: 666-73. PMID 21368900 DOI: 10.1038/Gt.2011.10 |
0.602 |
|
| 2011 |
Gordon KL, Glenn KA, Gonzalez-Alegre P. Exploring the influence of torsinA expression on protein quality control. Neurochemical Research. 36: 452-9. PMID 21161590 DOI: 10.1007/S11064-010-0363-4 |
0.656 |
|
| 2010 |
Harris GM, Dodelzon K, Gong L, Gonzalez-Alegre P, Paulson HL. Splice isoforms of the polyglutamine disease protein ataxin-3 exhibit similar enzymatic yet different aggregation properties. Plos One. 5: e13695. PMID 21060878 DOI: 10.1371/Journal.Pone.0013695 |
0.678 |
|
| 2010 |
Page ME, Bao L, Andre P, Pelta-Heller J, Sluzas E, Gonzalez-Alegre P, Bogush A, Khan LE, Iacovitti L, Rice ME, Ehrlich ME. Cell-autonomous alteration of dopaminergic transmission by wild type and mutant (DeltaE) TorsinA in transgenic mice. Neurobiology of Disease. 39: 318-26. PMID 20460154 DOI: 10.1016/J.Nbd.2010.04.016 |
0.399 |
|
| 2009 |
Martin JN, Bair TB, Bode N, Dauer WT, Gonzalez-Alegre P. Transcriptional and proteomic profiling in a cellular model of DYT1 dystonia. Neuroscience. 164: 563-72. PMID 19665049 DOI: 10.1016/J.Neuroscience.2009.07.068 |
0.624 |
|
| 2008 |
Bassuk AG, Wallace RH, Buhr A, Buller AR, Afawi Z, Shimojo M, Miyata S, Chen S, Gonzalez-Alegre P, Griesbach HL, Wu S, Nashelsky M, Vladar EK, Antic D, Ferguson PJ, et al. A homozygous mutation in human PRICKLE1 causes an autosomal-recessive progressive myoclonus epilepsy-ataxia syndrome. American Journal of Human Genetics. 83: 572-81. PMID 18976727 DOI: 10.1016/J.Ajhg.2008.10.003 |
0.334 |
|
| 2008 |
Gordon KL, Gonzalez-Alegre P. Consequences of the DYT1 mutation on torsinA oligomerization and degradation. Neuroscience. 157: 588-95. PMID 18940237 DOI: 10.1016/J.Neuroscience.2008.09.028 |
0.675 |
|
| 2008 |
Harper SQ, Gonzalez-Alegre P. Lentivirus-mediated RNA interference in mammalian neurons. Methods in Molecular Biology (Clifton, N.J.). 442: 95-112. PMID 18369781 DOI: 10.1007/978-1-59745-191-8_8 |
0.347 |
|
| 2007 |
Gonzalez-Alegre P, Paulson HL. Technology insight: therapeutic RNA interference--how far from the neurology clinic? Nature Clinical Practice. Neurology. 3: 394-404. PMID 17611488 DOI: 10.1038/Ncpneuro0551 |
0.374 |
|
| 2007 |
Gonzalez-Alegre P. The inherited dystonias. Seminars in Neurology. 27: 151-8. PMID 17390260 DOI: 10.1055/S-2007-971170 |
0.304 |
|
| 2007 |
Gonzalez-Alegre P. Therapeutic RNA interference for neurodegenerative diseases: From promise to progress. Pharmacology & Therapeutics. 114: 34-55. PMID 17316816 DOI: 10.1016/J.Pharmthera.2007.01.003 |
0.386 |
|
| 2007 |
Gonzalez-Alegre P. Monomelic parkinsonian tremor caused by contralateral substantia nigra stroke. Parkinsonism & Related Disorders. 13: 182-4. PMID 16731026 DOI: 10.1016/J.Parkreldis.2006.03.011 |
0.313 |
|
| 2006 |
Gonzalez-Alegre P, Afifi AK. Clinical characteristics of childhood-onset (juvenile) Huntington disease: report of 12 patients and review of the literature. Journal of Child Neurology. 21: 223-9. PMID 16901424 DOI: 10.2310/7010.2006.00055 |
0.31 |
|
| 2006 |
Rodriguez-Lebron E, Gonzalez-Alegre P. Silencing neurodegenerative disease: bringing RNA interference to the clinic. Expert Review of Neurotherapeutics. 6: 223-33. PMID 16466302 DOI: 10.1586/14737175.6.2.223 |
0.345 |
|
| 2005 |
Miller VM, Paulson HL, Gonzalez-Alegre P. RNA interference in neuroscience: progress and challenges. Cellular and Molecular Neurobiology. 25: 1195-207. PMID 16388332 DOI: 10.1007/S10571-005-8447-4 |
0.31 |
|
| 2005 |
Gonzalez-Alegre P, Bode N, Davidson BL, Paulson HL. Silencing primary dystonia: lentiviral-mediated RNA interference therapy for DYT1 dystonia. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 25: 10502-9. PMID 16280588 DOI: 10.1523/Jneurosci.3016-05.2005 |
0.42 |
|
| 2004 |
Gonzalez-Alegre P, Paulson HL. Aberrant cellular behavior of mutant torsinA implicates nuclear envelope dysfunction in DYT1 dystonia. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 24: 2593-601. PMID 15028751 DOI: 10.1523/Jneurosci.4461-03.2004 |
0.425 |
|
| 2003 |
Gonzalez-Alegre P, Miller VM, Davidson BL, Paulson HL. Toward therapy for DYT1 dystonia: allele-specific silencing of mutant TorsinA. Annals of Neurology. 53: 781-7. PMID 12783425 DOI: 10.1002/Ana.10548 |
0.411 |
|
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