Pedro Gonzalez-Alegre, M.D. - Publications

Affiliations: 
University of Iowa, Iowa City, IA 

41 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2020 Robbins NM, Ozmore JR, Winder TL, Gonzalez-Alegre P, Bardakjian TM. A Novel SPAST/SPG4 Splice-Site Variant in a Family with Dominant Hereditary Spastic Paraplegia. Case Reports in Neurological Medicine. 2020: 7219514. PMID 32908740 DOI: 10.1155/2020/7219514  0.307
2019 Gonzalez-Alegre P, Beauvais G, Martin J, Koch RJ, Walker RH, Patel JC, Rice ME, Ehrlich ME. A novel transgenic mouse model to investigate the cell-autonomous effects of torsinA(ΔE) expression in striatal output neurons. Neuroscience. PMID 31669362 DOI: 10.1016/J.Neuroscience.2019.09.007  0.571
2019 Hitti FL, Yang AI, Gonzalez-Alegre P, Baltuch GH. Human gene therapy approaches for the treatment of Parkinson's disease: An overview of current and completed clinical trials. Parkinsonism & Related Disorders. PMID 31324556 DOI: 10.1016/J.Parkreldis.2019.07.018  0.3
2019 Gonzalez-Alegre P. Advances in molecular and cell biology of dystonia: Focus on torsinA. Neurobiology of Disease. 127: 233-241. PMID 30877032 DOI: 10.1016/J.Nbd.2019.03.007  0.396
2018 Maguire JA, Gagne AL, Gonzalez-Alegre P, Davidson BL, Shakkottai V, Gadue P, French DL. Generation of Spinocerebellar Ataxia Type 2 induced pluripotent stem cell lines, CHOPi002-A and CHOPi003-A, from patients with abnormal CAG repeats in the coding region of the ATXN2 gene. Stem Cell Research. 34: 101361. PMID 30611021 DOI: 10.1016/J.Scr.2018.101361  0.315
2018 Beauvais G, Watson JL, Aguirre JA, Tecedor L, Ehrlich ME, Gonzalez-Alegre P. Efficient RNA interference-based knockdown of mutant torsinA reveals reversibility of PERK-eIF2α pathway dysregulation in DYT1 transgenic rats in vivo. Brain Research. PMID 30366018 DOI: 10.1016/J.Brainres.2018.10.025  0.319
2018 Hitti FL, Gonzalez-Alegre P, Lucas TH. Gene Therapy for Neurological Disease: A Neurosurgical Review. World Neurosurgery. PMID 30253990 DOI: 10.1016/J.Wneu.2018.09.097  0.303
2018 Zakirova Z, Fanutza T, Bonet J, Readhead B, Zhang W, Yi Z, Beauvais G, Zwaka TP, Ozelius LJ, Blitzer RD, Gonzalez-Alegre P, Ehrlich ME. Mutations in THAP1/DYT6 reveal that diverse dystonia genes disrupt similar neuronal pathways and functions. Plos Genetics. 14: e1007169. PMID 29364887 DOI: 10.1371/Journal.Pgen.1007169  0.401
2017 Mendizabal A, Ngo Vu AT, Thibault D, Gonzalez-Alegre P, Willis A. Hospitalizations of Children with Huntington's Disease in the United States. Movement Disorders Clinical Practice. 4: 682-688. PMID 30363491 DOI: 10.1002/Mdc3.12506  0.321
2017 Beauvais G, Rodriguez-Losada N, Ying L, Zakirova Z, Watson JL, Readhead B, Gadue P, French DL, Ehrlich ME, Gonzalez-Alegre P. Exploring the Interaction Between eIF2α Dysregulation, Acute Endoplasmic Reticulum Stress and DYT1 Dystonia in the Mammalian Brain. Neuroscience. PMID 29289717 DOI: 10.1016/J.Neuroscience.2017.12.033  0.366
2017 Aguilo F, Zakirova Z, Nolan K, Wagner R, Sharma R, Hogan M, Wei C, Sun Y, Walsh MJ, Kelley K, Zhang W, Ozelius LJ, Gonzalez-Alegre P, Zwaka TP, Ehrlich ME. THAP1: Role in Mouse Embryonic Stem Cell Survival and Differentiation. Stem Cell Reports. PMID 28579396 DOI: 10.1016/J.Stemcr.2017.04.032  0.394
2016 Beauvais G, Bode NM, Watson JL, Wen H, Glenn KA, Kawano H, Harata NC, Ehrlich ME, Gonzalez-Alegre P. Disruption of Protein Processing in the Endoplasmic Reticulum of DYT1 Knock-in Mice Implicates Novel Pathways in Dystonia Pathogenesis. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 36: 10245-10256. PMID 27707963 DOI: 10.1523/Jneurosci.0669-16.2016  0.428
2016 Klionsky DJ, Abdelmohsen K, Abe A, Abedin MJ, Abeliovich H, Acevedo Arozena A, Adachi H, Adams CM, Adams PD, Adeli K, Adhihetty PJ, Adler SG, Agam G, Agarwal R, Aghi MK, ... ... Gonzalez-Alegre P, et al. Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition). Autophagy. 12: 1-222. PMID 26799652 DOI: 10.1080/15548627.2015.1100356  0.333
2015 Keiser MS, Kordower JH, Gonzalez-Alegre P, Davidson BL. Broad distribution of ataxin 1 silencing in rhesus cerebella for spinocerebellar ataxia type 1 therapy. Brain : a Journal of Neurology. PMID 26490326 DOI: 10.1093/Brain/Awv292  0.374
2015 Ruiz M, Perez-Garcia G, Ortiz-Virumbrales M, Méneret A, Morant A, Kottwitz J, Fuchs T, Bonet J, Gonzalez-Alegre P, Hof PR, Ozelius LJ, Ehrlich ME. Abnormalities of motor function, transcription and cerebellar structure in mouse models of THAP1 dystonia. Human Molecular Genetics. PMID 26376866 DOI: 10.1093/Hmg/Ddv384  0.392
2014 Noetzli L, Sanz PG, Brodsky GL, Hinckley JD, Giugni JC, Giannaula RJ, Gonzalez-Alegre P, Di Paola J. A novel mutation in PLP1 causes severe hereditary spastic paraplegia type 2. Gene. 533: 447-50. PMID 24103481 DOI: 10.1016/J.Gene.2013.09.076  0.398
2013 Paemka L, Mahajan VB, Skeie JM, Sowers LP, Ehaideb SN, Gonzalez-Alegre P, Sasaoka T, Tao H, Miyagi A, Ueno N, Takao K, Miyakawa T, Wu S, Darbro BW, Ferguson PJ, et al. PRICKLE1 interaction with SYNAPSIN I reveals a role in autism spectrum disorders. Plos One. 8: e80737. PMID 24312498 DOI: 10.1371/Journal.Pone.0080737  0.367
2013 Gonzalez-Alegre P, Buffard V, Wang K, Henien S, Morcuende JA. Exploring the link between dystonia genes and idiopathic scoliosis. Journal of Pediatric Orthopedics. 33: e65-6. PMID 23812140 DOI: 10.1097/Bpo.0B013E31829Aac15  0.354
2013 Letort D, Gonzalez-Alegre P. Huntington's disease in children. Handbook of Clinical Neurology. 113: 1913-7. PMID 23622414 DOI: 10.1016/B978-0-444-59565-2.00061-7  0.342
2012 Gordon KL, Glenn KA, Bode N, Wen HM, Paulson HL, Gonzalez-Alegre P. The ubiquitin ligase F-box/G-domain protein 1 promotes the degradation of the disease-linked protein torsinA through the ubiquitin-proteasome pathway and macroautophagy. Neuroscience. 224: 160-71. PMID 22917612 DOI: 10.1016/J.Neuroscience.2012.08.023  0.666
2012 Bode N, Massey C, Gonzalez-Alegre P. DYT1 knock-in mice are not sensitized against mitochondrial complex-II inhibition. Plos One. 7: e42644. PMID 22880064 DOI: 10.1371/Journal.Pone.0042644  0.37
2012 Kakazu Y, Koh JY, Iwabuchi S, Gonzalez-Alegre P, Harata NC. Miniature release events of glutamate from hippocampal neurons are influenced by the dystonia-associated protein torsinA. Synapse (New York, N.Y.). 66: 807-22. PMID 22588999 DOI: 10.1002/Syn.21571  0.344
2012 Kakazu Y, Koh JY, Ho KW, Gonzalez-Alegre P, Harata NC. Synaptic vesicle recycling is enhanced by torsinA that harbors the DYT1 dystonia mutation. Synapse (New York, N.Y.). 66: 453-64. PMID 22213465 DOI: 10.1002/Syn.21534  0.313
2011 Martin JN, Wolken N, Brown T, Dauer WT, Ehrlich ME, Gonzalez-Alegre P. Lethal toxicity caused by expression of shRNA in the mouse striatum: implications for therapeutic design. Gene Therapy. 18: 666-73. PMID 21368900 DOI: 10.1038/Gt.2011.10  0.602
2011 Gordon KL, Glenn KA, Gonzalez-Alegre P. Exploring the influence of torsinA expression on protein quality control. Neurochemical Research. 36: 452-9. PMID 21161590 DOI: 10.1007/S11064-010-0363-4  0.656
2010 Harris GM, Dodelzon K, Gong L, Gonzalez-Alegre P, Paulson HL. Splice isoforms of the polyglutamine disease protein ataxin-3 exhibit similar enzymatic yet different aggregation properties. Plos One. 5: e13695. PMID 21060878 DOI: 10.1371/Journal.Pone.0013695  0.678
2010 Page ME, Bao L, Andre P, Pelta-Heller J, Sluzas E, Gonzalez-Alegre P, Bogush A, Khan LE, Iacovitti L, Rice ME, Ehrlich ME. Cell-autonomous alteration of dopaminergic transmission by wild type and mutant (DeltaE) TorsinA in transgenic mice. Neurobiology of Disease. 39: 318-26. PMID 20460154 DOI: 10.1016/J.Nbd.2010.04.016  0.399
2009 Martin JN, Bair TB, Bode N, Dauer WT, Gonzalez-Alegre P. Transcriptional and proteomic profiling in a cellular model of DYT1 dystonia. Neuroscience. 164: 563-72. PMID 19665049 DOI: 10.1016/J.Neuroscience.2009.07.068  0.624
2008 Bassuk AG, Wallace RH, Buhr A, Buller AR, Afawi Z, Shimojo M, Miyata S, Chen S, Gonzalez-Alegre P, Griesbach HL, Wu S, Nashelsky M, Vladar EK, Antic D, Ferguson PJ, et al. A homozygous mutation in human PRICKLE1 causes an autosomal-recessive progressive myoclonus epilepsy-ataxia syndrome. American Journal of Human Genetics. 83: 572-81. PMID 18976727 DOI: 10.1016/J.Ajhg.2008.10.003  0.335
2008 Gordon KL, Gonzalez-Alegre P. Consequences of the DYT1 mutation on torsinA oligomerization and degradation. Neuroscience. 157: 588-95. PMID 18940237 DOI: 10.1016/J.Neuroscience.2008.09.028  0.675
2008 Harper SQ, Gonzalez-Alegre P. Lentivirus-mediated RNA interference in mammalian neurons. Methods in Molecular Biology (Clifton, N.J.). 442: 95-112. PMID 18369781 DOI: 10.1007/978-1-59745-191-8_8  0.347
2007 Gonzalez-Alegre P, Paulson HL. Technology insight: therapeutic RNA interference--how far from the neurology clinic? Nature Clinical Practice. Neurology. 3: 394-404. PMID 17611488 DOI: 10.1038/Ncpneuro0551  0.373
2007 Gonzalez-Alegre P. The inherited dystonias. Seminars in Neurology. 27: 151-8. PMID 17390260 DOI: 10.1055/S-2007-971170  0.303
2007 Gonzalez-Alegre P. Therapeutic RNA interference for neurodegenerative diseases: From promise to progress. Pharmacology & Therapeutics. 114: 34-55. PMID 17316816 DOI: 10.1016/J.Pharmthera.2007.01.003  0.385
2007 Gonzalez-Alegre P. Monomelic parkinsonian tremor caused by contralateral substantia nigra stroke. Parkinsonism & Related Disorders. 13: 182-4. PMID 16731026 DOI: 10.1016/J.Parkreldis.2006.03.011  0.313
2006 Gonzalez-Alegre P, Afifi AK. Clinical characteristics of childhood-onset (juvenile) Huntington disease: report of 12 patients and review of the literature. Journal of Child Neurology. 21: 223-9. PMID 16901424 DOI: 10.2310/7010.2006.00055  0.31
2006 Rodriguez-Lebron E, Gonzalez-Alegre P. Silencing neurodegenerative disease: bringing RNA interference to the clinic. Expert Review of Neurotherapeutics. 6: 223-33. PMID 16466302 DOI: 10.1586/14737175.6.2.223  0.344
2005 Miller VM, Paulson HL, Gonzalez-Alegre P. RNA interference in neuroscience: progress and challenges. Cellular and Molecular Neurobiology. 25: 1195-207. PMID 16388332 DOI: 10.1007/S10571-005-8447-4  0.31
2005 Gonzalez-Alegre P, Bode N, Davidson BL, Paulson HL. Silencing primary dystonia: lentiviral-mediated RNA interference therapy for DYT1 dystonia. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 25: 10502-9. PMID 16280588 DOI: 10.1523/Jneurosci.3016-05.2005  0.42
2004 Gonzalez-Alegre P, Paulson HL. Aberrant cellular behavior of mutant torsinA implicates nuclear envelope dysfunction in DYT1 dystonia. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 24: 2593-601. PMID 15028751 DOI: 10.1523/Jneurosci.4461-03.2004  0.425
2003 Gonzalez-Alegre P, Miller VM, Davidson BL, Paulson HL. Toward therapy for DYT1 dystonia: allele-specific silencing of mutant TorsinA. Annals of Neurology. 53: 781-7. PMID 12783425 DOI: 10.1002/Ana.10548  0.411
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