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Rachelle Gaudet, Ph.D. - Publications

Affiliations: 
2002- Molecular and Cellular Biology Harvard University, Cambridge, MA, United States 
Area:
Structural biology of signaling and transport through biological membranes
Website:
https://projects.iq.harvard.edu/gaudetlab/home

78 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2023 Frank HM, Walujkar S, Walsh RM, Laursen WJ, Theobald DL, Garrity PA, Gaudet R. Structure of an insect gustatory receptor. Biorxiv : the Preprint Server For Biology. PMID 38187590 DOI: 10.1101/2023.12.19.572336  0.675
2023 Ray S, Gaudet R. Structures and coordination chemistry of transporters involved in manganese and iron homeostasis. Biochemical Society Transactions. PMID 37283482 DOI: 10.1042/BST20210699  0.591
2023 Ray S, Berry SP, Wilson EA, Zhang CH, Shekhar M, Singharoy A, Gaudet R. High-resolution structures with bound Mn and Cd map the metal import pathway in an Nramp transporter. Elife. 12. PMID 37039477 DOI: 10.7554/eLife.84006  0.6
2022 Zhang L, Simonsen C, Zimova L, Wang K, Moparthi L, Gaudet R, Ekoff M, Nilsson G, Hellmich UA, Vlachova V, Gourdon P, Zygmunt PM. Cannabinoid non-cannabidiol site modulation of TRPV2 structure and function. Nature Communications. 13: 7483. PMID 36470868 DOI: 10.1038/s41467-022-35163-y  0.657
2022 Velilla JA, Volpe MR, Kenney GE, Walsh RM, Balskus EP, Gaudet R. Structural basis of colibactin activation by the ClbP peptidase. Nature Chemical Biology. PMID 36253550 DOI: 10.1038/s41589-022-01142-z  0.302
2020 Thomas C, Aller SG, Beis K, Carpenter EP, Chang G, Chen L, Dassa E, Dean M, Duong Van Hoa F, Ekiert D, Ford R, Gaudet R, Gong X, Holland IB, Huang Y, et al. Structural and functional diversity calls for a new classification of ABC transporters. Febs Letters. PMID 32978974 DOI: 10.1002/1873-3468.13935  0.323
2020 Srikant S, Gaudet R, Murray AW. Selecting for Altered Substrate Specificity Reveals the Evolutionary Flexibility of ATP-Binding Cassette Transporters. Current Biology : Cb. PMID 32220325 DOI: 10.1016/J.Cub.2020.02.077  0.393
2019 Bozzi AT, McCabe AL, Barnett BC, Gaudet R. Transmembrane helix 6b links proton- and metal-release pathways and drives conformational change in an Nramp-family transition metal transporter. The Journal of Biological Chemistry. PMID 31882536 DOI: 10.1074/Jbc.Ra119.011336  0.35
2019 Bozzi AT, Bane LB, Zimanyi CM, Gaudet R. Unique structural features in an Nramp metal transporter impart substrate-specific proton cotransport and a kinetic bias to favor import. The Journal of General Physiology. PMID 31619456 DOI: 10.1085/Jgp.201912428  0.317
2019 Srikant S, Gaudet R. Mechanics and pharmacology of substrate selection and transport by eukaryotic ABC exporters. Nature Structural & Molecular Biology. PMID 31451804 DOI: 10.1038/S41594-019-0280-4  0.373
2019 Nicoludis JM, Green AG, Walujkar S, May EJ, Sotomayor M, Marks DS, Gaudet R. Interaction specificity of clustered protocadherins inferred from sequence covariation and structural analysis. Proceedings of the National Academy of Sciences of the United States of America. PMID 31431536 DOI: 10.1073/Pnas.1821063116  0.632
2019 Bozzi AT, Zimanyi CM, Nicoludis JM, Lee BK, Zhang CH, Gaudet R. Structures in multiple conformations reveal distinct transition metal and proton pathways in an Nramp transporter. Elife. 8. PMID 30714568 DOI: 10.2210/Pdb6D9W/Pdb  0.35
2019 Gaudet R, Jiang Y. Decision letter: Structure-based characterization of novel TRPV5 inhibitors Elife. DOI: 10.7554/Elife.49572.041  0.6
2019 Bozzi AT, Zimanyi CM, Nicoludis JM, Lee BK, Zhang CH, Gaudet R. Author response: Structures in multiple conformations reveal distinct transition metal and proton pathways in an Nramp transporter Elife. DOI: 10.7554/Elife.41124.044  0.312
2018 Finol-Urdaneta RK, McArthur JR, Goldschen-Ohm MP, Gaudet R, Tikhonov DB, Zhorov BS, French RJ. Batrachotoxin acts as a stent to hold open homotetrameric prokaryotic voltage-gated sodium channels. The Journal of General Physiology. PMID 30587506 DOI: 10.1085/Jgp.201812278  0.414
2018 Goretzki B, Glogowski NA, Diehl E, Duchardt-Ferner E, Hacker C, Gaudet R, Hellmich UA. Structural Basis of TRPV4 N Terminus Interaction with Syndapin/PACSIN1-3 and PIP. Structure (London, England : 1993). PMID 30244966 DOI: 10.1016/J.Str.2018.08.002  0.717
2017 Nicoludis JM, Gaudet R. Applications of sequence coevolution in membrane protein biochemistry. Biochimica Et Biophysica Acta. PMID 28993150 DOI: 10.1016/J.Bbamem.2017.10.004  0.308
2017 Woll KA, Skinner KA, Gianti E, Bhanu NV, Garcia BA, Carnevale V, Eckenhoff RG, Gaudet R. Sites Contributing to TRPA1 Activation by the Anesthetic Propofol Identified by Photoaffinity Labeling. Biophysical Journal. PMID 28935134 DOI: 10.1016/J.Bpj.2017.08.040  0.41
2017 Vakkasoglu AS, Srikant S, Gaudet R. D-helix influences dimerization of the ATP-binding cassette (ABC) transporter associated with antigen processing 1 (TAP1) nucleotide-binding domain. Plos One. 12: e0178238. PMID 28542489 DOI: 10.1371/Journal.Pone.0178238  0.428
2017 Bradshaw N, Levdikov VM, Zimanyi CM, Gaudet R, Wilkinson AJ, Losick R. A widespread family of serine/threonine protein phosphatases shares a common regulatory switch with proteasomal proteases. Elife. 6. PMID 28527238 DOI: 10.7554/Elife.26111  0.343
2017 Powers RE, Gaudet R, Sotomayor M. A Partial Calcium-Free Linker Confers Flexibility to Inner-Ear Protocadherin-15. Structure (London, England : 1993). PMID 28238533 DOI: 10.1016/J.Str.2017.01.014  0.66
2016 Bozzi AT, Bane LB, Weihofen WA, Singharoy A, Guillen ER, Ploegh HL, Schulten K, Gaudet R. Crystal Structure and Conformational Change Mechanism of a Bacterial Nramp-Family Divalent Metal Transporter. Structure (London, England : 1993). PMID 27839948 DOI: 10.1016/J.Str.2016.09.017  0.522
2016 Bozzi AT, Bane LB, Weihofen WA, McCabe AL, Singharoy A, Chipot CJ, Schulten K, Gaudet R. Conserved methionine dictates substrate preference in Nramp-family divalent metal transporters. Proceedings of the National Academy of Sciences of the United States of America. PMID 27573840 DOI: 10.1073/Pnas.1607734113  0.495
2016 Nicoludis JM, Vogt BE, Green AG, Schärfe CP, Marks DS, Gaudet R. Antiparallel protocadherin homodimers use distinct affinity- and specificity-mediating regions in cadherin repeats 1-4. Elife. 5. PMID 27472898 DOI: 10.7554/Elife.18449  0.358
2016 Meyer PA, Socias S, Key J, Ransey E, Tjon EC, Buschiazzo A, Lei M, Botka C, Withrow J, Neau D, Rajashankar K, Anderson KS, Baxter RH, Blacklow SC, Boggon TJ, ... ... Gaudet R, et al. Data publication with the structural biology data grid supports live analysis. Nature Communications. 7: 10882. PMID 26947396 DOI: 10.1038/Ncomms10882  0.588
2016 Finol-Urdaneta RK, McArthur JR, Gaudet R, French RJ. Functional Modification of Bacterial Voltage-Gated Sodium Channels by Batrachotoxin Biophysical Journal. 110: 109a. DOI: 10.1016/J.Bpj.2015.11.647  0.446
2015 Sullivan JM, Zimanyi CM, Aisenberg W, Bears B, Chen DH, Day JW, Bird TD, Siskind CE, Gaudet R, Sumner CJ. Novel mutations highlight the key role of the ankyrin repeat domain in TRPV4-mediated neuropathy. Neurology. Genetics. 1: e29. PMID 27066566 DOI: 10.1212/Nxg.0000000000000029  0.319
2015 Nicoludis JM, Lau SY, Schärfe CP, Marks DS, Weihofen WA, Gaudet R. Structure and Sequence Analyses of Clustered Protocadherins Reveal Antiparallel Interactions that Mediate Homophilic Specificity. Structure (London, England : 1993). 23: 2087-98. PMID 26481813 DOI: 10.1016/J.Str.2015.09.005  0.335
2015 Brewster MS, Gaudet R. How the TRPA1 receptor transmits painful stimuli: Inner workings revealed by electron cryomicroscopy. Bioessays : News and Reviews in Molecular, Cellular and Developmental Biology. 37: 1184-92. PMID 26387779 DOI: 10.1002/Bies.201500085  0.486
2015 Knecht ZA, Gaudet R, Garrity PA. The Touching Tail of a Mechanotransduction Channel. Cell. 162: 1214-6. PMID 26359983 DOI: 10.1016/J.Cell.2015.08.049  0.659
2015 Sysoeva TA, Bane LB, Xiao DY, Bose B, Chilton SS, Gaudet R, Burton BM. Structural characterization of the late competence protein ComFB from Bacillus subtilis. Bioscience Reports. 35. PMID 25423369 DOI: 10.1042/Bsr20140174  0.362
2015 Powers RE, Gaudet R, Sotomayor M. Structural Study of a Novel Partial Calcium-Free Linker and a Positively Selected Variation in Protocadherin-15: Implications for Hearing and Cell Adhesion Biophysical Journal. 108: 505a. DOI: 10.1016/J.Bpj.2014.11.2765  0.676
2015 Gaudet R. Structural Determinants of TRPV Channel Activation and Modulation Biophysical Journal. 108: 8a-9a. DOI: 10.1016/J.Bpj.2014.11.069  0.441
2014 Hellmich UA, Gaudet R. High-resolution views of TRPV1 and their implications for the TRP channel superfamily. Handbook of Experimental Pharmacology. 223: 991-1004. PMID 24961977 DOI: 10.1007/978-3-319-05161-1_11  0.689
2014 Hellmich UA, Gaudet R. Structural biology of TRP channels. Handbook of Experimental Pharmacology. 223: 963-90. PMID 24961976 DOI: 10.1007/978-3-319-05161-1_10  0.68
2014 Sotomayor M, Gaudet R, Corey DP. Sorting out a promiscuous superfamily: towards cadherin connectomics. Trends in Cell Biology. 24: 524-36. PMID 24794279 DOI: 10.1016/J.Tcb.2014.03.007  0.721
2014 Sotomayor M, Gaudet R, Corey DP. Molecular Mechanisms of Deafness Mutations Disrupting Tip-Link Function in Hair-Cell Mechanotransduction Biophysical Journal. 106: 449a. DOI: 10.1016/J.Bpj.2013.11.2546  0.743
2013 Garcia-Elias A, Mrkonjic S, Pardo-Pastor C, Inada H, Hellmich UA, Rubio-Moscardó F, Plata C, Gaudet R, Vicente R, Valverde MA. Phosphatidylinositol-4,5-biphosphate-dependent rearrangement of TRPV4 cytosolic tails enables channel activation by physiological stimuli. Proceedings of the National Academy of Sciences of the United States of America. 110: 9553-8. PMID 23690576 DOI: 10.1073/Pnas.1220231110  0.706
2013 Perálvarez-Marín A, Doñate-Macian P, Gaudet R. What do we know about the transient receptor potential vanilloid 2 (TRPV2) ion channel? The Febs Journal. 280: 5471-87. PMID 23615321 DOI: 10.1111/Febs.12302  0.371
2013 Geng R, Sotomayor M, Kinder KJ, Gopal SR, Gerka-Stuyt J, Chen DH, Hardisty-Hughes RE, Ball G, Parker A, Gaudet R, Furness D, Brown SD, Corey DP, Alagramam KN. Noddy, a mouse harboring a missense mutation in protocadherin-15, reveals the impact of disrupting a critical interaction site between tip-link cadherins in inner ear hair cells. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 33: 4395-404. PMID 23467356 DOI: 10.1523/Jneurosci.4514-12.2013  0.729
2013 Sotomayor M, Weihofen WA, Gaudet R, Corey DP. Structures and Simulated Dynamics of a Force-Conveying Cadherin Bond Essential for Inner-Ear Mechanotransduction Biophysical Journal. 104: 166a. DOI: 10.1016/J.Bpj.2012.11.937  0.746
2012 Sotomayor M, Weihofen WA, Gaudet R, Corey DP. Structure of a force-conveying cadherin bond essential for inner-ear mechanotransduction. Nature. 492: 128-32. PMID 23135401 DOI: 10.1038/Nature11590  0.741
2012 Lau SY, Procko E, Gaudet R. Distinct properties of Ca2+-calmodulin binding to N- and C-terminal regulatory regions of the TRPV1 channel. The Journal of General Physiology. 140: 541-55. PMID 23109716 DOI: 10.1085/Jgp.201210810  0.715
2012 Inada H, Procko E, Sotomayor M, Gaudet R. Structural and biochemical consequences of disease-causing mutations in the ankyrin repeat domain of the human TRPV4 channel. Biochemistry. 51: 6195-206. PMID 22702953 DOI: 10.1021/Bi300279B  0.793
2012 Perálvarez-Marín A, Doñate-Macián P, Inada H, Mingarro I, Gaudet R. Biophysical Characterization of TRPV2 Ion Channel Biophysical Journal. 102: 342a. DOI: 10.1016/J.Bpj.2011.11.1876  0.396
2011 Sotomayor M, Weihofen WA, Gaudet R, Corey DP. Molecular mechanics of tip-link cadherins Aip Conference Proceedings. 1403: 64-69. DOI: 10.1063/1.3658062  0.67
2011 Inada H, Gaudet R. Structural Comparison of Ankyrin Repeat Domain of TRPV Channels Biophysical Journal. 100: 108a. DOI: 10.1016/J.Bpj.2010.12.795  0.521
2010 Zimo? M, Baets J, Auer-Grumbach M, Berciano J, Garcia A, Lopez-Laso E, Merlini L, Hilton-Jones D, McEntagart M, Crosby AH, Barisic N, Boltshauser E, Shaw CE, Landouré G, Ludlow CL, ... Gaudet R, et al. Dominant mutations in the cation channel gene transient receptor potential vanilloid 4 cause an unusual spectrum of neuropathies. Brain : a Journal of Neurology. 133: 1798-809. PMID 20460441 DOI: 10.1093/Brain/Awq109  0.339
2010 Sotomayor M, Weihofen WA, Gaudet R, Corey DP. Structural determinants of cadherin-23 function in hearing and deafness. Neuron. 66: 85-100. PMID 20399731 DOI: 10.1016/J.Neuron.2010.03.028  0.754
2010 Artavanis-Tsakonas K, Weihofen WA, Antos JM, Coleman BI, Comeaux CA, Duraisingh MT, Gaudet R, Ploegh HL. Characterization and structural studies of the Plasmodium falciparum ubiquitin and Nedd8 hydrolase UCHL3. The Journal of Biological Chemistry. 285: 6857-66. PMID 20042598 DOI: 10.1074/Jbc.M109.072405  0.348
2010 Landouré G, Zdebik AA, Martinez TL, Burnett BG, Stanescu HC, Inada H, Shi Y, Taye AA, Kong L, Munns CH, Choo SS, Phelps CB, Paudel R, Houlden H, Ludlow CL, ... ... Gaudet R, et al. Mutations in TRPV4 cause Charcot-Marie-Tooth disease type 2C. Nature Genetics. 42: 170-4. PMID 20037586 DOI: 10.1038/Ng.512  0.347
2010 Phelps CB, Wang RR, Choo SS, Gaudet R. Differential regulation of TRPV1, TRPV3, and TRPV4 sensitivity through a conserved binding site on the ankyrin repeat domain. The Journal of Biological Chemistry. 285: 731-40. PMID 19864432 DOI: 10.1074/Jbc.M109.052548  0.466
2010 Gaudet R. Heat and Spice: Setting the Sensitivity of TRPV Channels Biophysical Journal. 98: 421a. DOI: 10.1016/J.Bpj.2009.12.2279  0.439
2009 Procko E, Gaudet R. Antigen processing and presentation: TAPping into ABC transporters. Current Opinion in Immunology. 21: 84-91. PMID 19261456 DOI: 10.1016/J.Coi.2009.02.003  0.693
2009 Gaudet R. Divide and conquer: high resolution structural information on TRP channel fragments. The Journal of General Physiology. 133: 231-7. PMID 19237587 DOI: 10.1085/Jgp.200810137  0.365
2009 Procko E, O'Mara ML, Bennett WF, Tieleman DP, Gaudet R. The mechanism of ABC transporters: general lessons from structural and functional studies of an antigenic peptide transporter. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 23: 1287-302. PMID 19174475 DOI: 10.1096/Fj.08-121855  0.68
2008 Gaudet R. The ABCs of trans(porter) inhibition. Nature Chemical Biology. 4: 454-5. PMID 18641624 DOI: 10.1038/Nchembio0808-454  0.328
2008 Gaudet R. TRP channels entering the structural era. The Journal of Physiology. 586: 3565-75. PMID 18535090 DOI: 10.1113/Jphysiol.2008.155812  0.388
2008 Procko E, Gaudet R. Functionally important interactions between the nucleotide-binding domains of an antigenic peptide transporter. Biochemistry. 47: 5699-708. PMID 18452308 DOI: 10.1021/Bi7024854  0.696
2008 Gaudet R. A primer on ankyrin repeat function in TRP channels and beyond. Molecular Biosystems. 4: 372-9. PMID 18414734 DOI: 10.1039/B801481G  0.425
2008 Phelps CB, Huang RJ, Lishko PV, Wang RR, Gaudet R. Structural analyses of the ankyrin repeat domain of TRPV6 and related TRPV ion channels. Biochemistry. 47: 2476-84. PMID 18232717 DOI: 10.1021/Bi702109W  0.708
2007 Phelps CB, Procko E, Lishko PV, Wang RR, Gaudet R. Insights into the roles of conserved and divergent residues in the ankyrin repeats of TRPV ion channels. Channels (Austin, Tex.). 1: 148-51. PMID 18690026 DOI: 10.4161/Chan.4716  0.782
2007 Phelps CB, Gaudet R. The role of the N terminus and transmembrane domain of TRPM8 in channel localization and tetramerization. The Journal of Biological Chemistry. 282: 36474-80. PMID 17908685 DOI: 10.1074/Jbc.M707205200  0.401
2007 Lishko PV, Procko E, Jin X, Phelps CB, Gaudet R. The ankyrin repeats of TRPV1 bind multiple ligands and modulate channel sensitivity. Neuron. 54: 905-18. PMID 17582331 DOI: 10.1016/J.Neuron.2007.05.027  0.801
2007 Schlieker C, Weihofen WA, Frijns E, Kattenhorn LM, Gaudet R, Ploegh HL. Structure of a herpesvirus-encoded cysteine protease reveals a unique class of deubiquitinating enzymes. Molecular Cell. 25: 677-87. PMID 17349955 DOI: 10.1016/J.Molcel.2007.01.033  0.35
2006 Procko E, Ferrin-O'Connell I, Ng SL, Gaudet R. Distinct structural and functional properties of the ATPase sites in an asymmetric ABC transporter. Molecular Cell. 24: 51-62. PMID 17018292 DOI: 10.1016/J.Molcel.2006.07.034  0.698
2006 Jin X, Touhey J, Gaudet R. Structure of the N-terminal ankyrin repeat domain of the TRPV2 ion channel. The Journal of Biological Chemistry. 281: 25006-10. PMID 16809337 DOI: 10.1074/Jbc.C600153200  0.605
2005 Procko E, Raghuraman G, Wiley DC, Raghavan M, Gaudet R. Identification of domain boundaries within the N-termini of TAP1 and TAP2 and their importance in tapasin binding and tapasin-mediated increase in peptide loading of MHC class I. Immunology and Cell Biology. 83: 475-82. PMID 16174096 DOI: 10.1111/J.1440-1711.2005.01354.X  0.741
2005 Misaghi S, Galardy PJ, Meester WJ, Ovaa H, Ploegh HL, Gaudet R. Structure of the ubiquitin hydrolase UCH-L3 complexed with a suicide substrate. The Journal of Biological Chemistry. 280: 1512-20. PMID 15531586 DOI: 10.1074/Jbc.M410770200  0.345
2004 Misaghi S, Sun ZY, Stern P, Gaudet R, Wagner G, Ploegh H. Structural and functional analysis of human cytomegalovirus US3 protein. Journal of Virology. 78: 413-23. PMID 14671122 DOI: 10.1128/Jvi.78.1.413-423.2004  0.342
2002 Obin M, Lee BY, Meinke G, Bohm A, Lee RH, Gaudet R, Hopp JA, Arshavsky VY, Willardson BM, Taylor A. Ubiquitylation of the transducin betagamma subunit complex. Regulation by phosducin. The Journal of Biological Chemistry. 277: 44566-75. PMID 12215439 DOI: 10.1074/Jbc.M205308200  0.312
2001 Gaudet R, Wiley DC. Structure of the ABC ATPase domain of human TAP1, the transporter associated with antigen processing. The Embo Journal. 20: 4964-72. PMID 11532960 DOI: 10.1093/Emboj/20.17.4964  0.614
2001 Gewurz BE, Gaudet R, Tortorella D, Wang EW, Ploegh HL. Virus subversion of immunity: a structural perspective. Current Opinion in Immunology. 13: 442-50. PMID 11498300 DOI: 10.1016/S0952-7915(00)00239-9  0.318
2001 Gewurz BE, Gaudet R, Tortorella D, Wang EW, Ploegh HL, Wiley DC. Antigen presentation subverted: Structure of the human cytomegalovirus protein US2 bound to the class I molecule HLA-A2. Proceedings of the National Academy of Sciences of the United States of America. 98: 6794-9. PMID 11391001 DOI: 10.1073/Pnas.121172898  0.596
2001 Holm M, Hardtke CS, Gaudet R, Deng XW. Identification of a structural motif that confers specific interaction with the WD40 repeat domain of Arabidopsis COP1. The Embo Journal. 20: 118-27. PMID 11226162 DOI: 10.1093/Emboj/20.1.118  0.362
1999 Gaudet R, Savage JR, McLaughlin JN, Willardson BM, Sigler PB. A molecular mechanism for the phosphorylation-dependent regulation of heterotrimeric G proteins by phosducin. Molecular Cell. 3: 649-60. PMID 10360181 DOI: 10.1016/S1097-2765(00)80358-5  0.535
1997 Bohm A, Gaudet R, Sigler PB. Structural aspects of heterotrimeric G-protein signaling. Current Opinion in Biotechnology. 8: 480-7. PMID 9265729 DOI: 10.1016/S0958-1669(97)80072-9  0.576
1996 Gaudet R, Bohm A, Sigler PB. Crystal structure at 2.4 angstroms resolution of the complex of transducin betagamma and its regulator, phosducin. Cell. 87: 577-88. PMID 8898209 DOI: 10.1016/S0092-8674(00)81376-8  0.628
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