Teodoro G. Bottiglieri - Publications

Baylor University, Waco, TX 
Neuroscience Biology

101 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2020 Gu SX, Sonkar VK, Katare PB, Kumar R, Kruger WD, Arning E, Bottiglieri T, Lentz SR, Dayal S. Memantine Protects From Exacerbation of Ischemic Stroke and Blood Brain Barrier Disruption in Mild But Not Severe Hyperhomocysteinemia. Journal of the American Heart Association. 9: e013368. PMID 32067580 DOI: 10.1161/Jaha.119.013368  0.32
2018 Arora K, Sequeira JM, Alarcon JM, Wasek B, Arning E, Bottiglieri T, Quadros EV. Neuropathology of vitamin B deficiency in the Cd320 mouse. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. fj201800754RR. PMID 30303736 DOI: 10.1096/Fj.201800754Rr  0.32
2018 Dheda K, Lenders L, Magombedze G, Srivastava S, Raj P, Arning E, Ashcraft P, Bottiglieri T, Wainwright H, Pennel T, Linegar A, Moodley L, Pooran A, Pasipanodya JG, Sirgel FA, et al. Drug Penetration Gradients Associated with Acquired Drug Resistance in Tuberculosis Patients. American Journal of Respiratory and Critical Care Medicine. PMID 29877726 DOI: 10.1164/Rccm.201711-2333Oc  0.32
2018 Christensen KE, Bahous RH, Hou W, Deng L, Malysheva OV, Arning E, Bottiglieri T, Caudill MA, Jerome-Majewska LA, Rozen R. Low Dietary Folate Interacts with MTHFD1 Synthetase Deficiency in Mice, a Model for the R653Q Variant, to Increase Incidence of Developmental Delays and Defects. The Journal of Nutrition. 148: 501-509. PMID 29659962 DOI: 10.1093/Jn/Nxy013  0.32
2017 Meng XL, Arning E, Wight-Carter M, Day TS, Jabbarzadeh-Tabrizi S, Chen S, Ziegler RJ, Bottiglieri T, Schneider JW, Cheng SH, Schiffmann R, Shen JS. Priapism in a Fabry disease mouse model is associated with upregulated penile nNOS and eNOS expression. Journal of Inherited Metabolic Disease. PMID 29110178 DOI: 10.1007/S10545-017-0107-6  0.32
2017 Dayal S, Baumbach GL, Arning E, Bottiglieri T, Faraci FM, Lentz SR. Deficiency of superoxide dismutase promotes cerebral vascular hypertrophy and vascular dysfunction in hyperhomocysteinemia. Plos One. 12: e0175732. PMID 28414812 DOI: 10.1371/Journal.Pone.0175732  0.32
2017 Belik J, Shifrin Y, Arning E, Bottiglieri T, Pan J, Daigneault MC, Allen-Vercoe E. Corrigendum: Intestinal microbiota as a tetrahydrobiopterin exogenous source in hph-1 mice. Scientific Reports. 7: 44161. PMID 28398297 DOI: 10.1038/Srep44161  0.32
2017 Shen JS, Arning E, West ML, Day TS, Chen S, Meng XL, Forni S, McNeill N, Goker-Alpan O, Wang X, Ashcraft P, Moore DF, Cheng SH, Schiffmann R, Bottiglieri T. Tetrahydrobiopterin deficiency in the pathogenesis of Fabry disease. Human Molecular Genetics. PMID 28158561 DOI: 10.1093/Hmg/Ddx032  0.32
2017 Belik J, Shifrin Y, Arning E, Bottiglieri T, Pan J, Daigneault MC, Allen-Vercoe E. Intestinal microbiota as a tetrahydrobiopterin exogenous source in hph-1 mice. Scientific Reports. 7: 39854. PMID 28079055 DOI: 10.1038/Srep39854  0.32
2017 Shen J, Arning E, West ML, Day TS, Cheng SH, Schiffmann R, Bottiglieri T. Tetrahydrobiopterin deficiency in the pathogenesis of Fabry disease Molecular Genetics and Metabolism. 120. DOI: 10.1016/J.Ymgme.2016.11.319  0.32
2016 Vogel KR, Arning E, Bottiglieri T, Gibson KM. Multicompartment analysis of protein-restricted phenylketonuric mice reveals amino acid imbalances in brain. Journal of Inherited Metabolic Disease. PMID 27761676 DOI: 10.1007/S10545-016-9984-3  0.32
2016 Christensen KE, Hou W, Bahous RH, Deng L, Malysheva OV, Arning E, Bottiglieri T, Caudill MA, Jerome-Majewska LA, Rozen R. Moderate folic acid supplementation and MTHFD1-synthetase deficiency in mice, a model for the R653Q variant, result in embryonic defects and abnormal placental development. The American Journal of Clinical Nutrition. PMID 27707701 DOI: 10.3945/Ajcn.116.139519  0.32
2016 Wexler O, Gough MS, Morgan MA, Mack CM, Apostolakos MJ, Doolin KP, Mooney RA, Arning E, Bottiglieri T, Pietropaoli AP. Methionine Metabolites in Patients With Sepsis. Journal of Intensive Care Medicine. PMID 27591199 DOI: 10.1177/0885066616666002  0.32
2016 Arning E, Bottiglieri T. Quantitation of S-Adenosylmethionine and S-Adenosylhomocysteine in Plasma Using Liquid Chromatography-Electrospray Tandem Mass Spectrometry Methods of Molecular Biology. 1378: 255-262. PMID 26602137 DOI: 10.1007/978-1-4939-3182-8_27  0.32
2016 Arning E, Bottiglieri T. Quantitation of 5-Methyltetrahydrofolate in Cerebrospinal Fluid Using Liquid Chromatography-Electrospray Tandem Mass Spectrometry. Methods of Molecular Biology. 1378: 175-182. PMID 26602129 DOI: 10.1007/978-1-4939-3182-8_19  0.32
2016 Arning E, Bottiglieri T. Quantification of γ-Aminobutyric Acid in Cerebrospinal Fluid Using Liquid Chromatography-Electrospray Tandem Mass Spectrometry. Methods of Molecular Biology. 1378: 109-118. PMID 26602123 DOI: 10.1007/978-1-4939-3182-8_13  0.32
2015 Singhal NK, Li S, Arning E, Alkhayer K, Clements R, Sarcyk Z, Dassanayake RS, Brasch NE, Freeman EJ, Bottiglieri T, McDonough J. Changes in Methionine Metabolism and Histone H3 Trimethylation Are Linked to Mitochondrial Defects in Multiple Sclerosis. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 35: 15170-86. PMID 26558787 DOI: 10.1523/Jneurosci.4349-14.2015  0.32
2015 Morgan TR, Osann K, Bottiglieri T, Pimstone N, Hoefs JC, Hu KQ, Hassanein T, Boyer T, Kong L, Chen WP, Richmond E, Gonzalez R, Rodriguez LM, Meyskens FL. A phase II, randomized, controlled trial of S-adenosylmethionine in reducing serum alpha-fetoprotein (AFP) in patients with hepatitis C cirrhosis and elevated AFP. Cancer Prevention Research (Philadelphia, Pa.). PMID 26130251 DOI: 10.1158/1940-6207.Capr-15-0029  0.32
2015 Vogel KR, Ainslie GR, Phillips B, Arning E, Bottiglieri T, Shen DD, Gibson KM. Physiological Competition of Brain Phenylalanine Accretion: Initial Pharmacokinetic Analyses of Aminoisobutyric and Methylaminoisobutyric Acids in Pah(enu2-/-) Mice. Molecular Genetics and Metabolism Reports. 3: 80-87. PMID 26120559 DOI: 10.1016/J.Ymgmr.2015.03.009  0.32
2015 Strauss KA, Ferreira C, Bottiglieri T, Zhao X, Arning E, Zhang S, Zeisel SH, Escolar ML, Presnick N, Puffenberger EG, Vugrek O, Kovacevic L, Wagner C, Mazariegos GV, Mudd SH, et al. Liver transplantation for treatment of severe S-adenosylhomocysteine hydrolase deficiency. Molecular Genetics and Metabolism. PMID 26095522 DOI: 10.1016/J.Ymgme.2015.06.005  0.32
2014 Gerbarg PL, Muskin PR, Bottiglieri T, Brown RP. Failed studies should not be used to malign good treatments. The Journal of Clinical Psychiatry. 75: e1328. PMID 25470102 DOI: 10.4088/Jcp.14Lr09266  0.32
2014 Pfalzer AC, Choi SW, Tammen SA, Park LK, Bottiglieri T, Parnell LD, Lamon-Fava S. S-adenosylmethionine mediates inhibition of inflammatory response and changes in DNA methylation in human macrophages. Physiological Genomics. 46: 617-23. PMID 25180283 DOI: 10.1152/Physiolgenomics.00056.2014  0.32
2014 Fang P, Zhang D, Cheng Z, Yan C, Jiang X, Kruger WD, Meng S, Arning E, Bottiglieri T, Choi ET, Han Y, Yang XF, Wang H. Hyperhomocysteinemia potentiates hyperglycemia-induced inflammatory monocyte differentiation and atherosclerosis. Diabetes. 63: 4275-90. PMID 25008174 DOI: 10.2337/Db14-0809  0.32
2014 Vogel KR, Arning E, Wasek BL, McPherson S, Bottiglieri T, Gibson KM. Brain-blood amino acid correlates following protein restriction in murine maple syrup urine disease. Orphanet Journal of Rare Diseases. 9: 73. PMID 24886632 DOI: 10.1186/1750-1172-9-73  0.32
2014 Papakostas GI, Shelton RC, Zajecka JM, Bottiglieri T, Roffman J, Cassiello C, Stahl SM, Fava M. Effect of adjunctive L-methylfolate 15 mg among inadequate responders to SSRIs in depressed patients who were stratified by biomarker levels and genotype: results from a randomized clinical trial. The Journal of Clinical Psychiatry. 75: 855-63. PMID 24813065 DOI: 10.4088/Jcp.13M08947  0.32
2014 Harding CO, Winn SR, Gibson KM, Arning E, Bottiglieri T, Grompe M. Pharmacologic inhibition of L-tyrosine degradation ameliorates cerebral dopamine deficiency in murine phenylketonuria (PKU). Journal of Inherited Metabolic Disease. 37: 735-43. PMID 24487571 DOI: 10.1007/S10545-013-9675-2  0.32
2014 Yano S, Moseley K, Bottiglieri T, Arning E, Azen C. Maternal Phenylketonuria International Collaborative Study revisited: evaluation of maternal nutritional risk factors besides phenylalanine for fetal congenital heart defects Journal of Inherited Metabolic Disease. 37: 39-42. PMID 23784316 DOI: 10.1007/S10545-013-9627-X  0.32
2013 Vogel KR, Arning E, Wasek BL, Bottiglieri T, Gibson KM. Characterization of 2-(methylamino)alkanoic acid capacity to restrict blood-brain phenylalanine transport in Pah enu2 mice: preliminary findings. Molecular Genetics and Metabolism. 110: S71-8. PMID 23999161 DOI: 10.1016/J.Ymgme.2013.08.004  0.32
2013 Inoue-Choi M, Nelson HH, Robien K, Arning E, Bottiglieri T, Koh WP, Yuan JM. Plasma S-adenosylmethionine, DNMT polymorphisms, and peripheral blood LINE-1 methylation among healthy Chinese adults in Singapore. Bmc Cancer. 13: 389. PMID 23957506 DOI: 10.1186/1471-2407-13-389  0.32
2013 Butler LM, Arning E, Wang R, Bottiglieri T, Govindarajan S, Gao YT, Yuan JM. Prediagnostic levels of serum one-carbon metabolites and risk of hepatocellular carcinoma. Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association For Cancer Research, Cosponsored by the American Society of Preventive Oncology. 22: 1884-93. PMID 23897582 DOI: 10.1158/1055-9965.Epi-13-0497  0.32
2013 Christensen KE, Deng L, Leung KY, Arning E, Bottiglieri T, Malysheva OV, Caudill MA, Krupenko NI, Greene ND, Jerome-Majewska L, MacKenzie RE, Rozen R. A novel mouse model for genetic variation in 10-formyltetrahydrofolate synthetase exhibits disturbed purine synthesis with impacts on pregnancy and embryonic development Human Molecular Genetics. 22: 3705-3719. PMID 23704330 DOI: 10.1093/Hmg/Ddt223  0.32
2013 Skvorak KJ, Dorko K, Marongiu F, Tahan V, Hansel MC, Gramignoli R, Arning E, Bottiglieri T, Gibson KM, Strom SC. Improved amino acid, bioenergetic metabolite and neurotransmitter profiles following human amnion epithelial cell transplant in intermediate maple syrup urine disease mice. Molecular Genetics and Metabolism. 109: 132-8. PMID 23566440 DOI: 10.1016/J.Ymgme.2013.02.011  0.32
2013 Lai SC, Nakayama Y, Sequeira JM, Wlodarczyk BJ, Cabrera RM, Finnell RH, Bottiglieri T, Quadros EV. The transcobalamin receptor knockout mouse: a model for vitamin B12 deficiency in the central nervous system. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 27: 2468-75. PMID 23430977 DOI: 10.1096/Fj.12-219055  0.32
2013 Glier MB, Ngai YF, Sulistyoningrum DC, Aleliunas RE, Bottiglieri T, Devlin AM. Tissue-specific relationship of S-adenosylhomocysteine with allele-specific H19/Igf2 methylation and imprinting in mice with hyperhomocysteinemia Epigenetics. 8: 44-53. PMID 23221482 DOI: 10.4161/Epi.23063  0.32
2013 Fonseca VA, Lavery LA, Thethi TK, Daoud Y, DeSouza C, Ovalle F, Denham DS, Bottiglieri T, Sheehan P, Rosenstock J. Metanx in type 2 diabetes with peripheral neuropathy: a randomized trial. The American Journal of Medicine. 126: 141-9. PMID 23218892 DOI: 10.1016/J.Amjmed.2012.06.022  0.32
2013 Vogel KR, Arning E, Wasek BL, Bottiglieri T, Gibson KM. Non-physiological amino acid (NPAA) therapy targeting brain phenylalanine reduction: pilot studies in PAHENU2 mice. Journal of Inherited Metabolic Disease. 36: 513-23. PMID 22976763 DOI: 10.1007/S10545-012-9524-8  0.32
2012 Papakostas GI, Shelton RC, Zajecka JM, Etemad B, Rickels K, Clain A, Baer L, Dalton ED, Sacco GR, Schoenfeld D, Pencina M, Meisner A, Bottiglieri T, Nelson E, Mischoulon D, et al. L-methylfolate as adjunctive therapy for SSRI-resistant major depression: results of two randomized, double-blind, parallel-sequential trials. The American Journal of Psychiatry. 169: 1267-74. PMID 23212058 DOI: 10.1176/Appi.Ajp.2012.11071114  0.32
2012 Bottiglieri T, Arning E, Wasek B, Nunbhakdi-Craig V, Sontag J, Sontag E. Acute administration of L-DOPA induces changes in methylation metabolites, reduced protein phosphatase 2A methylation, and hyperphosphorylation of Tau protein in mouse brain. The Journal of Neuroscience. 32: 9173-9181. PMID 22764226 DOI: 10.1523/Jneurosci.0125-12.2012  0.32
2012 Mischoulon D, Alpert JE, Arning E, Bottiglieri T, Fava M, Papakostas GI. Bioavailability of S-adenosyl methionine and impact on response in a randomized, double-blind, placebo-controlled trial in major depressive disorder. The Journal of Clinical Psychiatry. 73: 843-8. PMID 22687580 DOI: 10.4088/Jcp.11M07139  0.32
2012 Marin-Valencia I, Good LB, Ma Q, Duarte J, Bottiglieri T, Sinton CM, Heilig CW, Pascual JM. Glut1 deficiency (G1D): epilepsy and metabolic dysfunction in a mouse model of the most common human phenotype. Neurobiology of Disease. 48: 92-101. PMID 22683290 DOI: 10.1016/J.Nbd.2012.04.011  0.32
2012 Inoue-Choi M, Nelson HH, Robien K, Arning E, Bottiglieri T, Koh W, Yuan J. Abstract 1038: PlasmaS-adenosylmethionine levels, genetic polymorphisms ofDNMT1andDNMT3A, and LINE-1 DNA methylation among Chinese in Singapore Cancer Research. 72: 1038-1038. DOI: 10.1158/1538-7445.Am2012-1038  0.32
2011 Gough MS, Morgan MA, Mack CM, Darling DC, Frasier LM, Doolin KP, Apostolakos MJ, Stewart JC, Graves BT, Arning E, Bottiglieri T, Mooney RA, Frampton MW, Pietropaoli AP. The ratio of arginine to dimethylarginines is reduced and predicts outcomes in patients with severe sepsis. Critical Care Medicine. 39: 1351-8. PMID 21378552 DOI: 10.1097/Ccm.0B013E318212097C  0.32
2010 Kathirvel E, Morgan K, Nandgiri G, Sandoval BC, Caudill MA, Bottiglieri T, French SW, Morgan TR. Betaine improves nonalcoholic fatty liver and associated hepatic insulin resistance: a potential mechanism for hepatoprotection by betaine. American Journal of Physiology. Gastrointestinal and Liver Physiology. 299: G1068-77. PMID 20724529 DOI: 10.1152/Ajpgi.00249.2010  0.32
2010 Iskandar BJ, Rizk E, Meier B, Hariharan N, Bottiglieri T, Finnell RH, Jarrard DF, Banerjee RV, Skene JH, Nelson A, Patel N, Gherasim C, Simon K, Cook TD, Hogan KJ. Folate regulation of axonal regeneration in the rodent central nervous system through DNA methylation. The Journal of Clinical Investigation. 120: 1603-16. PMID 20424322 DOI: 10.1172/Jci40000  0.32
2010 Rodionov RN, Dayoub H, Lynch CM, Wilson KM, Stevens JW, Murry DJ, Kimoto M, Arning E, Bottiglieri T, Cooke JP, Baumbach GL, Faraci FM, Lentz SR. Overexpression of dimethylarginine dimethylaminohydrolase protects against cerebral vascular effects of hyperhomocysteinemia. Circulation Research. 106: 551-8. PMID 20019334 DOI: 10.1161/Circresaha.109.200360  0.32
2010 Devlin AM, Singh R, Bottiglieri T, Innis SM, Green TJ. Hepatic acyl-coenzyme A:cholesterol acyltransferase-2 expression is decreased in mice with hyperhomocysteinemia Journal of Nutrition. 140: 231-237. PMID 20018805 DOI: 10.3945/Jn.109.112920  0.32
2009 Roe CR, Bottiglieri T, Wallace M, Arning E, Martin A. Adult Polyglucosan Body Disease (APBD): Anaplerotic diet therapy (Triheptanoin) and demonstration of defective methylation pathways Molecular Genetics and Metabolism. 101: 246-252. PMID 20655781 DOI: 10.1016/J.Ymgme.2010.06.017  0.32
2009 Skvorak KJ, Hager EJ, Arning E, Bottiglieri T, Paul HS, Strom SC, Homanics GE, Sun Q, Jansen EE, Jakobs C, Zinnanti WJ, Gibson KM. Hepatocyte transplantation (HTx) corrects selected neurometabolic abnormalities in murine intermediate maple syrup urine disease (iMSUD). Biochimica Et Biophysica Acta. 1792: 1004-10. PMID 19699299 DOI: 10.1016/J.Bbadis.2009.08.006  0.32
2009 Li S, Arning E, Liu C, Vitvitsky V, Hernandez C, Banerjee R, Bottiglieri T, Lin JD. Regulation of homocysteine homeostasis through the transcriptional coactivator PGC-1alpha. American Journal of Physiology. Endocrinology and Metabolism. 296: E543-8. PMID 19158324 DOI: 10.1152/Ajpendo.90719.2008  0.32
2009 Roe C, Arning E, Bottiglieri T, Reuser A. 117. IGF-1 resistance is a reversible feature of late-onset acid maltase deficiency (AMD) Molecular Genetics and Metabolism. 96. DOI: 10.1016/J.Ymgme.2008.11.118  0.32
2008 Sontag JM, Nunbhakdi-Craig V, Montgomery L, Arning E, Bottiglieri T, Sontag E. Folate deficiency induces in vitro and mouse brain region-specific downregulation of leucine carboxyl methyltransferase-1 and protein phosphatase 2A B(alpha) subunit expression that correlate with enhanced tau phosphorylation. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 28: 11477-87. PMID 18987184 DOI: 10.1523/Jneurosci.2816-08.2008  0.32
2008 Aisen PS, Schneider LS, Sano M, Diaz-Arrastia R, van Dyck CH, Weiner MF, Bottiglieri T, Jin S, Stokes KT, Thomas RG, Thal LJ. High-dose B vitamin supplementation and cognitive decline in Alzheimer disease: a randomized controlled trial. Jama. 300: 1774-83. PMID 18854539 DOI: 10.1001/Jama.300.15.1774  0.32
2008 Dayal S, Rodionov RN, Arning E, Bottiglieri T, Kimoto M, Murry DJ, Cooke JP, Faraci FM, Lentz SR. Tissue-specific downregulation of dimethylarginine dimethylaminohydrolase in hyperhomocysteinemia American Journal of Physiology - Heart and Circulatory Physiology. 295: H816-H825. PMID 18567702 DOI: 10.1152/Ajpheart.01348.2007  0.32
2008 Locascio JJ, Fukumoto H, Yap L, Bottiglieri T, Growdon JH, Hyman BT, Irizarry MC. Plasma amyloid beta-protein and C-reactive protein in relation to the rate of progression of Alzheimer disease. Archives of Neurology. 65: 776-85. PMID 18541797 DOI: 10.1001/Archneur.65.6.776  0.32
2008 Dayoub H, Rodionov R, Lynch C, Cooke JP, Arning E, Bottiglieri T, Lentz SR, Faraci FM. Overexpression of dimethylarginine dimethylaminohydrolase inhibits asymmetric dimethylarginine-induced endothelial dysfunction in the cerebral circulation Stroke. 39: 180-184. PMID 18063827 DOI: 10.1161/Strokeaha.107.490631  0.32
2008 Moretti P, Peters SU, Del Gaudio D, Sahoo T, Hyland K, Bottiglieri T, Hopkin RJ, Peach E, Min SH, Goldman D, Roa B, Bacino CA, Scaglia F. Brief report: autistic symptoms, developmental regression, mental retardation, epilepsy, and dyskinesias in CNS folate deficiency. Journal of Autism and Developmental Disorders. 38: 1170-7. PMID 18027081 DOI: 10.1007/S10803-007-0492-Z  0.32
2008 Bottiglieri T, Anderson D, Diaz‐Arrastia R, Arning E. Poster Sessions AP10: Learning, Memory and Behavior Journal of Neurochemistry. 81: 23-24. DOI: 10.1046/J.1471-4159.81.S1.10_1.X  0.32
2007 Knerr I, Pearl PL, Bottiglieri T, Snead OC, Jakobs C, Gibson KM. Therapeutic concepts in succinate semialdehyde dehydrogenase (SSADH; ALDH5a1) deficiency (gamma-hydroxybutyric aciduria). Hypotheses evolved from 25 years of patient evaluation, studies in Aldh5a1-/- mice and characterization of gamma-hydroxybutyric acid pharmacology. Journal of Inherited Metabolic Disease. 30: 279-94. PMID 17457693 DOI: 10.1007/S10545-007-0574-2  0.32
2007 Elmore CL, Wu X, Leclerc D, Watson ED, Bottiglieri T, Krupenko NI, Krupenko SA, Cross JC, Rozen R, Gravel RA, Matthews RG. Metabolic derangement of methionine and folate metabolism in mice deficient in methionine synthase reductase. Molecular Genetics and Metabolism. 91: 85-97. PMID 17369066 DOI: 10.1016/J.Ymgme.2007.02.001  0.32
2007 Sontag E, Nunbhakdi-Craig V, Sontag JM, Diaz-Arrastia R, Ogris E, Dayal S, Lentz SR, Arning E, Bottiglieri T. Protein phosphatase 2A methyltransferase links homocysteine metabolism with tau and amyloid precursor protein regulation. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 27: 2751-9. PMID 17360897 DOI: 10.1523/Jneurosci.3316-06.2007  0.32
2007 Brown AS, Bottiglieri T, Schaefer CA, Quesenberry CP, Liu L, Bresnahan M, Susser ES. Elevated prenatal homocysteine levels as a risk factor for schizophrenia. Archives of General Psychiatry. 64: 31-9. PMID 17199052 DOI: 10.1001/Archpsyc.64.1.31  0.32
2007 Wilson KM, McCaw RB, Leo L, Arning E, Lhoták S, Bottiglieri T, Austin RC, Lentz SR. Prothrombotic effects of hyperhomocysteinemia and hypercholesterolemia in ApoE-deficient mice. Arteriosclerosis, Thrombosis, and Vascular Biology. 27: 233-40. PMID 17082485 DOI: 10.1161/01.Atv.0000251607.96118.Af  0.32
2006 Dayal S, Wilson KM, Leo L, Arning E, Bottiglieri T, Lentz SR. Enhanced susceptibility to arterial thrombosis in a murine model of hyperhomocysteinemia. Blood. 108: 2237-43. PMID 16804115 DOI: 10.1182/Blood-2006-02-005991  0.32
2006 Tirouvanziam R, Conrad CK, Bottiglieri T, Herzenberg LA, Moss RB, Herzenberg LA. High-dose oral N-acetylcysteine, a glutathione prodrug, modulates inflammation in cystic fibrosis. Proceedings of the National Academy of Sciences of the United States of America. 103: 4628-33. PMID 16537378 DOI: 10.1073/Pnas.0511304103  0.32
2006 Ogburn KD, Bottiglieri T, Wang Z, Figueiredo-Pereira ME. Prostaglandin J2 reduces catechol-O-methyltransferase activity and enhances dopamine toxicity in neuronal cells. Neurobiology of Disease. 22: 294-301. PMID 16406650 DOI: 10.1016/J.Nbd.2005.11.006  0.32
2006 Gurol ME, Irizarry MC, Smith EE, Raju S, Diaz-Arrastia R, Bottiglieri T, Rosand J, Growdon JH, Greenberg SM. Plasma beta-amyloid and white matter lesions in AD, MCI, and cerebral amyloid angiopathy. Neurology. 66: 23-9. PMID 16401840 DOI: 10.1212/01.Wnl.0000191403.95453.6A  0.32
2005 Irizarry MC, Gurol ME, Raju S, Diaz-Arrastia R, Locascio JJ, Tennis M, Hyman BT, Growdon JH, Greenberg SM, Bottiglieri T. Association of homocysteine with plasma amyloid beta protein in aging and neurodegenerative disease. Neurology. 65: 1402-8. PMID 16275827 DOI: 10.1212/01.Wnl.0000183063.99107.5C  0.32
2005 Neul JL, Maricich SM, Islam M, Barrish J, Smith EO, Bottiglieri T, Hyland K, Humphreys P, Percy A, Glaze D. Spinal fluid 5-methyltetrahydrofolate levels are normal in Rett syndrome. Neurology. 64: 2151-2. PMID 15985595 DOI: 10.1212/01.Wnl.0000166032.58239.6C  0.32
2005 Papakostas GI, Petersen T, Lebowitz BD, Mischoulon D, Ryan JL, Nierenberg AA, Bottiglieri T, Alpert JE, Rosenbaum JF, Fava M. The relationship between serum folate, vitamin B12, and homocysteine levels in major depressive disorder and the timing of improvement with fluoxetine. The International Journal of Neuropsychopharmacology / Official Scientific Journal of the Collegium Internationale Neuropsychopharmacologicum (Cinp). 8: 523-8. PMID 15877935 DOI: 10.1017/S1461145705005195  0.32
2005 Bodamer OA, Sahoo T, Beaudet AL, O'Brien WE, Bottiglieri T, Stöckler-Ipsiroglu S, Wagner C, Scaglia F. Creatine metabolism in combined methylmalonic aciduria and homocystinuria. Annals of Neurology. 57: 557-60. PMID 15786446 DOI: 10.1002/Ana.20419  0.32
2005 Moretti P, Sahoo T, Hyland K, Bottiglieri T, Peters S, del Gaudio D, Roa B, Curry S, Zhu H, Finnell RH, Neul JL, Ramaekers VT, Blau N, Bacino CA, Miller G, et al. Cerebral folate deficiency with developmental delay, autism, and response to folinic acid. Neurology. 64: 1088-90. PMID 15781839 DOI: 10.1212/01.Wnl.0000154641.08211.B7  0.32
2004 Alpert JE, Papakostas G, Mischoulon D, Worthington JJ, Petersen T, Mahal Y, Burns A, Bottiglieri T, Nierenberg AA, Fava M. S-adenosyl-L-methionine (SAMe) as an adjunct for resistant major depressive disorder: an open trial following partial or nonresponse to selective serotonin reuptake inhibitors or venlafaxine. Journal of Clinical Psychopharmacology. 24: 661-4. PMID 15538131 DOI: 10.1097/01.Jcp.0000145339.45794.Cd  0.32
2004 Duncan GE, Perri MG, Anton SD, Limacher MC, Martin AD, Lowenthal DT, Arning E, Bottiglieri T, Stacpoole PW. Effects of exercise on emerging and traditional cardiovascular risk factors. Preventive Medicine. 39: 894-902. PMID 15475021 DOI: 10.1016/J.Ypmed.2004.03.012  0.32
2004 Goff DC, Bottiglieri T, Arning E, Shih V, Freudenreich O, Evins AE, Henderson DC, Baer L, Coyle J. Folate, homocysteine, and negative symptoms in schizophrenia American Journal of Psychiatry. 161: 1705-1708. PMID 15337665 DOI: 10.1176/Appi.Ajp.161.9.1705  0.32
2004 Chin PC, Liu L, Morrison BE, Siddiq A, Ratan RR, Bottiglieri T, D'Mello SR. The c-Raf inhibitor GW5074 provides neuroprotection in vitro and in an animal model of neurodegeneration through a MEK-ERK and Akt-independent mechanism. Journal of Neurochemistry. 90: 595-608. PMID 15255937 DOI: 10.1111/J.1471-4159.2004.02530.X  0.32
2004 Dayal S, Arning E, Bottiglieri T, Böger RH, Sigmund CD, Faraci FM, Lentz SR. Cerebral vascular dysfunction mediated by superoxide in hyperhomocysteinemic mice. Stroke; a Journal of Cerebral Circulation. 35: 1957-62. PMID 15178827 DOI: 10.1161/01.Str.0000131749.81508.18  0.32
2004 Quinn CT, Griener JC, Bottiglieri T, Arning E, Winick NJ. Effects of intraventricular methotrexate on folate, adenosine, and homocysteine metabolism in cerebrospinal fluid. Journal of Pediatric Hematology/Oncology. 26: 386-8. PMID 15167354 DOI: 10.1097/00043426-200406000-00011  0.32
2004 Devlin AM, Arning E, Bottiglieri T, Faraci FM, Rozen R, Lentz SR. Effect of Mthfr genotype on diet-induced hyperhomocysteinemia and vascular function in mice Blood. 103: 2624-2629. PMID 14630804 DOI: 10.1182/Blood-2003-09-3078  0.32
2003 Gupta M, Hogema BM, Grompe M, Bottiglieri TG, Concas A, Biggio G, Sogliano C, Rigamonti AE, Pearl PL, Snead OC, Jakobs C, Gibson KM. Murine succinate semialdehyde dehydrogenase deficiency. Annals of Neurology. 54: S81-90. PMID 12891658 DOI: 10.1002/Ana.10625  0.32
2003 Harding CO, Pillers DA, Steiner RD, Bottiglieri T, Rosenblatt DS, Debley J, Michael Gibson K. Potential for misdiagnosis due to lack of metabolic derangement in combined methylmalonic aciduria/hyperhomocysteinemia (cblC) in the neonate. Journal of Perinatology : Official Journal of the California Perinatal Association. 23: 384-6. PMID 12847533 DOI: 10.1038/Sj.Jp.7210955  0.32
2002 Dayal S, Brown KL, Weydert CJ, Oberley LW, Arning E, Bottiglieri T, Faraci FM, Lentz SR. Deficiency of glutathione peroxidase-1 sensitizes hyperhomocysteinemic mice to endothelial dysfunction. Arteriosclerosis, Thrombosis, and Vascular Biology. 22: 1996-2002. PMID 12482825 DOI: 10.1161/01.Atv.0000041629.92741.Dc  0.32
2002 Lentz SR, Piegors DJ, Fernández JA, Erger RA, Arning E, René Malinow M, Griffin JH, Bottiglieri T, Haynes WG, Heistad DD. Effect of hyperhomocysteinemia on protein C activation and activity Blood. 100: 2108-2112. PMID 12200374 DOI: 10.1182/Blood-2002-03-0727  0.32
2002 Gibson KM, Schor DSM, Gupta M, Guerand WS, Senephansiri H, Burlingame TG, Bartels H, Hogema BM, Bottiglieri T, Froestl W, Snead OC, Grompe M, Jakobs C. Focal neurometabolic alterations in mice deficient for succinate semialdehyde dehydrogenase Journal of Neurochemistry. 81: 71-79. PMID 12067239 DOI: 10.1046/J.1471-4159.2002.00784.X  0.32
2001 Bottiglieri T, Parnetti L, Arning E, Ortiz T, Amici S, Lanari A, Gallai V. Plasma total homocysteine levels and the C677T mutation in the methylenetetrahydrofolate reductase (MTHFR) gene: a study in an Italian population with dementia. Mechanisms of Ageing and Development. 122: 2013-2023. PMID 11589919 DOI: 10.1016/S0047-6374(01)00307-4  0.32
2001 Hogema BM, Gupta M, Senephansiri H, Burlingame TG, Taylor M, Jakobs C, Schutgens RBH, Froestl W, Snead OC, Diaz-Arrastia R, Bottiglieri T, Grompe M, Gibson KM. Pharmacologic rescue of lethal seizures in mice deficient in succinate semialdehyde dehydrogenase Nature Genetics. 29: 212-216. PMID 11544478 DOI: 10.1038/Ng727  0.32
2001 Gallai V, Caso V, Paciaroni M, Cardaioli G, Arning E, Bottiglieri T, Parnetti L. Mild hyperhomocyst(e)inemia: a possible risk factor for cervical artery dissection. Stroke. 32: 714-718. PMID 11239192 DOI: 10.1161/01.Str.32.3.714  0.32
2001 Werner P, Di Rocco A, Prikhojan A, Rempel N, Bottiglieri T, Bressman S, Yahr MD. COMT-dependent protection of dopaminergic neurons by methionine, dimethionine and S-adenosylmethionine (SAM) against L-dopa toxicity in vitro. Brain Research. 893: 278-81. PMID 11223018 DOI: 10.1016/S0006-8993(00)03298-4  0.32
2001 Chen Z, Karaplis AC, Ackerman SL, Pogribny IP, Melnyk S, Lussier-Cacan S, Chen MF, Pai A, John SW, Smith RS, Bottiglieri T, Bagley P, Selhub J, Rudnicki MA, James SJ, et al. Mice deficient in methylenetetrahydrofolate reductase exhibit hyperhomocysteinemia and decreased methylation capacity, with neuropathology and aortic lipid deposition. Human Molecular Genetics. 10: 433-43. PMID 11181567 DOI: 10.1093/Hmg/10.5.433  0.32
2000 Bottiglieri T, Reynolds EH, Laundy M. Folate in CSF and age Journal of Neurology Neurosurgery and Psychiatry. 69: 562. PMID 11183038 DOI: 10.1136/Jnnp.69.4.562A  0.32
1999 Fava M, Rosenbaum JF, Kolsky AR, Alpert JE, Nierenberg AA, Spillmann M, Moore C, Renshaw P, Bottiglieri T, Moroz G, Magni G. Open study of the catechol-O-methyltransferase inhibitor tolcapone in major depressive disorder Journal of Clinical Psychopharmacology. 19: 329-335. PMID 10440460 DOI: 10.1097/00004714-199908000-00008  0.32
1998 Gibson KM, Hoffmann GF, Hodson AK, Bottiglieri T, Jakobs C. 4-hydroxybutyric acid and the clinical phenotype of succinic semialdehyde dehydrogenase deficiency, an inborn error of GABA metabolism Neuropediatrics. 29: 14-22. PMID 9553943 DOI: 10.1055/S-2007-973527  0.32
1997 Fava M, Borus JS, Alpert JE, Nierenberg AA, Rosenbaum JF, Bottiglieri T. Folate, vitamin B12, and homocysteine in major depressive disorder American Journal of Psychiatry. 154: 426-428. PMID 9054796 DOI: 10.1176/Ajp.154.3.426  0.32
1996 Metz J, Bell AH, Flicker L, Bottiglieri T, Ibrahim J, Seal E, Schultz D, Savoia H, McGrath KM. The significance of subnormal serum vitamin B12 concentration in older people: a case control study. Journal of the American Geriatrics Society. 44: 1355-61. PMID 8909352 DOI: 10.1111/J.1532-5415.1996.Tb01407.X  0.32
1995 Castagna A, Grazie CL, Accordini A, Giulidori P, Cavalli G, Bottiglieri T, Lazzarin A. Cerebrospinal fluid s-adenosylmethionine (same) and glutathione concentrations in hiv infection effect of parenteral treatment with same Neurology. 45: 1678-1683. PMID 7675226 DOI: 10.1212/Wnl.45.9.1678  0.32
1994 Bottiglieri T, Hyland K, Reynolds EH. The Clinical Potential of Ademetionine (S-Adenosylmethionine) in Neurological Disorders Drugs. 48: 137-152. PMID 7527320 DOI: 10.2165/00003495-199448020-00002  0.32
1993 Crellin R, Bottiglieri T, Reynolds EH. Folates and Psychiatric Disorders: Clinical Potential Drugs. 45: 623-636. PMID 7686459 DOI: 10.2165/00003495-199345050-00001  0.32
1990 Crellin RF, Bottiglieri T, Reynolds EH. Multiple sclerosis and macrocytosis Acta Neurologica Scandinavica. 81: 388-391. PMID 2375238 DOI: 10.1111/J.1600-0404.1990.Tb00981.X  0.32
1990 Deacon R, Bottiglieri T, Chanarin I, Lumb M, Perry J. Methylthioadenosine serves as a single carbon source to the folate co-enzyme pool in rat bone marrow cells. Biochimica Et Biophysica Acta. 1034: 342-6. PMID 2114175 DOI: 10.1016/0304-4165(90)90062-2  0.32
1990 PREEDY VR, HAMMOND B, BOTTIGLIERI TG, MARWAY JS, PETERS TJ. Measurement of Protein Synthesis by the Phenylalanine Flooding Dose Technique: Effect of Phenylalanine and Anaesthesia on Plasma Electrolyte, Enzyme and Metabolite Levels Journal of Pharmacy and Pharmacology. 42: 851-856. PMID 1983147 DOI: 10.1111/J.2042-7158.1990.Tb07039.X  0.32
1989 Lumb M, Bottiglieri T, Deacon R, Perry J, Chanarin I. Regulation of 5-methyltetrahydrofolate synthesis. The Biochemical Journal. 258: 611-2. PMID 2706003 DOI: 10.1042/Bj2580611  0.32
1986 Carney MW, Edeh J, Bottiglieri T, Reynolds EM, Toone BK. Affective illness and S-adenosyl methionine: a preliminary report. Clinical Neuropharmacology. 9: 379-85. PMID 2425961 DOI: 10.1097/00002826-198608000-00005  0.32
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