Bernard Brais, M.D., Ph.D., M.Phil. - Publications

Université de Montréal, Montréal, Canada 
Neurogenetics, neurodegenerative disorders, neuromuscular disorders, hereditary ataxias

120 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2020 Pelletier F, Perrier S, Cayami FK, Mirchi A, Saikali S, Tran LT, Ulrick N, Guerrero K, Rampakakis E, van Spaendonk RML, Naidu S, Pohl D, Gibson WT, Demos M, Goizet C, ... ... Brais B, et al. Endocrine and Growth Abnormalities in 4H Leukodystrophy Caused by Variants in POLR3A, POLR3B, and POLR1C. The Journal of Clinical Endocrinology and Metabolism. PMID 33005949 DOI: 10.1210/clinem/dgaa700  0.44
2020 Hodgkinson V, Lounsberry J, M'Dahoma S, Russell A, Benstead T, Brais B, Campbell C, Johnston W, Lochmüller H, McCormick A, Nguyen CT, O'Ferrall E, Oskoui M, Briemberg H, Bourque P, et al. The Canadian Neuromuscular Disease Registry 2010-2019: A Decade of Facilitating Clinical Research Through a Nationwide, Pan-Neuromuscular Disease Registry. Journal of Neuromuscular Diseases. PMID 32925088 DOI: 10.3233/JND-200538  0.44
2020 Bourcier D, Bélanger M, Côté I, Brais B, Synofzik M, Brisson JD, Rodrigue X, Gagnon MM, Mathieu J, Gagnon C. Documenting the psychometric properties of the scale for the assessment and rating of ataxia to advance trial readiness of Autosomal Recessive Spastic Ataxia of Charlevoix-Saguenay. Journal of the Neurological Sciences. 417: 117050. PMID 32736199 DOI: 10.1016/j.jns.2020.117050  0.36
2020 Dermer E, Spahr A, Tran LT, Mirchi A, Pelletier F, Guerrero K, Ahmed S, Brais B, Braverman N, Buhas D, Chandratre S, Chenier S, Chrestian N, Desmeules M, Dilenge ME, et al. Stress in Parents of Children With Genetically Determined Leukoencephalopathies: A Pilot Study. Journal of Child Neurology. 883073820938645. PMID 32720856 DOI: 10.1177/0883073820938645  0.44
2020 Hodgkinson V, Oskoui M, Lounsberry J, M'Dahoma S, Butler E, Campbell C, MacKenzie A, McMillan H, Simard L, Vajsar J, Brais B, Chapman K, Chrestian N, Crone M, Dobrowolski P, et al. A national spinal muscular atrophy registry for real world evidence. The Canadian Journal of Neurological Sciences. Le Journal Canadien Des Sciences Neurologiques. 1-18. PMID 32493524 DOI: 10.1017/cjn.2020.111  0.44
2020 Brisson JD, Gagnon C, Brais B, Côté I, Mathieu J. A study of impairments in Oculopharyngeal Muscular Dystrophy. Muscle & Nerve. PMID 32270505 DOI: 10.1002/mus.26888  0.36
2020 Pellerin D, Aykanat A, Ellezam B, Troiano EC, Karamchandani J, Dicaire MJ, Petitclerc M, Robertson R, Allard-Chamard X, Brunet D, Konersman CG, Mathieu J, Warman Chardon J, Gupta VA, Beggs AH, ... Brais B, et al. A Novel Recessive TNNT1 Congenital Core-Rod Myopathy in French Canadians. Annals of Neurology. PMID 31970803 DOI: 10.1002/ana.25685  0.44
2019 Akçimen F, Ross JP, Bourassa CV, Liao C, Rochefort D, Gama MTD, Dicaire MJ, Barsottini OG, Brais B, Pedroso JL, Dion PA, Rouleau GA. Investigation of the Repeat Expansion in a Canadian and a Brazilian Ataxia Cohort: Identification of Novel Conformations. Frontiers in Genetics. 10: 1219. PMID 31824583 DOI: 10.3389/fgene.2019.01219  0.56
2019 Gagnon C, Brais B, Lessard I, Lavoie C, Côté I, Mathieu J. Development and validation of a disease severity index for ataxia of Charlevoix-Saguenay. Neurology. PMID 31534027 DOI: 10.1212/WNL.0000000000008313  0.36
2019 Briand MM, Rodrigue X, Lessard I, Mathieu J, Brais B, Côté I, Gagnon C. Expanding the clinical description of autosomal recessive spastic ataxia of Charlevoix-Saguenay. Journal of the Neurological Sciences. 400: 39-41. PMID 30901567 DOI: 10.1016/j.jns.2019.03.008  0.36
2019 Larivière R, Sgarioto N, Márquez BT, Gaudet R, Choquet K, McKinney RA, Watt AJ, Brais B. Sacs R272C missense homozygous mice develop an ataxia phenotype. Molecular Brain. 12: 19. PMID 30866998 DOI: 10.1186/s13041-019-0438-3  0.52
2018 Gentil BJ, Lai GT, Menade M, Larivière R, Minotti S, Gehring K, Chapple JP, Brais B, Durham HD. Sacsin, mutated in the ataxia ARSACS, regulates intermediate filament assembly and dynamics. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. fj201801556R. PMID 30332300 DOI: 10.1096/fj.201801556R  0.32
2018 Gagnon C, Brais B, Lessard I, Lavoie C, Côté I, Mathieu J. From motor performance to participation: a quantitative descriptive study in adults with autosomal recessive spastic ataxia of Charlevoix-Saguenay. Orphanet Journal of Rare Diseases. 13: 165. PMID 30231904 DOI: 10.1186/s13023-018-0898-z  0.36
2018 Gagnon C, Lessard I, Lavoie C, Côté I, St-Gelais R, Mathieu J, Brais B. An exploratory natural history of ataxia of Charlevoix-Saguenay: A 2-year follow-up. Neurology. PMID 30158165 DOI: 10.1212/WNL.0000000000006290  0.36
2018 Abu-Baker A, Parker A, Ramalingam S, Laganiere J, Brais B, Neri C, Dion P, Rouleau G. Valproic acid is protective in cellular and worm models of oculopharyngeal muscular dystrophy. Neurology. PMID 30006409 DOI: 10.1212/WNL.0000000000005942  0.52
2018 Lessard I, Brais B, Côté I, Lavoie C, Synofzik M, Mathieu J, Gagnon C. Assessing mobility and balance in Autosomal Recessive Spastic Ataxia of Charlevoix-Saguenay population: Validity and reliability of four outcome measures. Journal of the Neurological Sciences. 390: 4-9. PMID 29801904 DOI: 10.1016/j.jns.2018.03.033  0.36
2018 Gagnon C, Lessard I, Brais B, Côté I, Lavoie C, Synofzik M, Mathieu J. Validity and reliability of outcome measures assessing dexterity, coordination, and upper limb strength in Autosomal Recessive Spastic Ataxia of Charlevoix-Saguenay. Archives of Physical Medicine and Rehabilitation. PMID 29462597 DOI: 10.1016/j.apmr.2018.01.026  0.36
2017 Gauquelin L, Tétreault M, Thiffault I, Farrow E, Miller N, Yoo B, Bareke E, Yoon G, Suchowersky O, Dupré N, Tarnopolsky M, Brais B, Wolf NI, Majewski J, Rouleau GA, et al. POLR3A variants in hereditary spastic paraplegia and ataxia. Brain : a Journal of Neurology. PMID 29228109 DOI: 10.1093/brain/awx290  0.56
2017 Lessard I, Lavoie C, Côté I, Mathieu J, Brais B, Gagnon C. Validity and reliability of the LEMOCOT in the adult ARSACS population: A measure of lower limb coordination. Journal of the Neurological Sciences. 377: 193-196. PMID 28477695 DOI: 10.1016/j.jns.2017.03.046  0.36
2017 Choquet K, Yang S, Moir RD, Forget D, Larivière R, Bouchard A, Poitras C, Sgarioto N, Dicaire MJ, Noohi F, Kennedy TE, Rochford J, Bernard G, Teichmann M, Coulombe B, ... ... Brais B, et al. Absence of neurological abnormalities in mice homozygous for the Polr3a G672E hypomyelinating leukodystrophy mutation. Molecular Brain. 10: 13. PMID 28407788 DOI: 10.1186/s13041-017-0294-y  0.32
2016 Shao YH, Choquet K, La Piana R, Tétreault M, Dicaire MJ, Boycott KM, Majewski J, Brais B. Mutations in GALC cause late-onset Krabbe disease with predominant cerebellar ataxia. Neurogenetics. PMID 26915362 DOI: 10.1007/s10048-016-0476-2  0.56
2015 Choquet K, Tétreault M, Yang S, La Piana R, Dicaire MJ, Vanstone MR, Mathieu J, Bouchard JP, Rioux MF, Rouleau GA, Boycott KM, Majewski J, Brais B. SPG7 mutations explain a significant proportion of French Canadian spastic ataxia cases. European Journal of Human Genetics : Ejhg. PMID 26626314 DOI: 10.1038/ejhg.2015.240  0.56
2015 Srour M, Hamdan FF, McKnight D, Davis E, Mandel H, Schwartzentruber J, Martin B, Patry L, Nassif C, Dionne-Laporte A, Ospina LH, Lemyre E, Massicotte C, Laframboise R, Maranda B, ... ... Brais B, et al. Joubert Syndrome in French Canadians and Identification of Mutations in CEP104. American Journal of Human Genetics. PMID 26477546 DOI: 10.1016/j.ajhg.2015.09.009  0.56
2015 Li X, Ménade M, Kozlov G, Hu Z, Dai Z, McPherson PS, Brais B, Gehring K. High-Throughput Screening for Ligands of the HEPN Domain of Sacsin. Plos One. 10: e0137298. PMID 26366743 DOI: 10.1371/journal.pone.0137298  0.56
2015 Sawyer SL, Hartley T, Dyment DA, Beaulieu CL, Schwartzentruber J, Smith A, Bedford HM, Bernard G, Bernier FP, Brais B, Bulman DE, Chardon JW, Chitayat D, Deladoëy J, Fernandez BA, et al. Utility of whole-exome sequencing for those near the end of the diagnostic odyssey: time to address gaps in care. Clinical Genetics. PMID 26283276 DOI: 10.1111/cge.12654  0.56
2015 Noreau A, La Piana R, Marcoux C, Dion PA, Brais B, Bernard G, Rouleau GA. Novel SIL1 mutations cause cerebellar ataxia and atrophy in a French-Canadian family. Neurogenetics. PMID 26260654 DOI: 10.1007/s10048-015-0455-z  0.56
2015 Thiffault I, Wolf NI, Forget D, Guerrero K, Tran LT, Choquet K, Lavallée-Adam M, Poitras C, Brais B, Yoon G, Sztriha L, Webster RI, Timmann D, van de Warrenburg BP, Seeger J, et al. Recessive mutations in POLR1C cause a leukodystrophy by impairing biogenesis of RNA polymerase III. Nature Communications. 6: 7623. PMID 26151409 DOI: 10.1038/ncomms8623  0.56
2015 Tétreault M, Gonzalez M, Dicaire MJ, Allard P, Gehring K, Leblanc D, Leclerc N, Schondorf R, Mathieu J, Zuchner S, Brais B. Adult-onset painful axonal polyneuropathy caused by a dominant NAGLU mutation. Brain : a Journal of Neurology. 138: 1477-83. PMID 25818867 DOI: 10.1093/brain/awv074  0.56
2015 Choquet K, La Piana R, Brais B. A novel frameshift mutation in FGF14 causes an autosomal dominant episodic ataxia. Neurogenetics. 16: 233-6. PMID 25566820 DOI: 10.1007/s10048-014-0436-7  0.56
2015 Larivière R, Gaudet R, Gentil BJ, Girard M, Conte TC, Minotti S, Leclerc-Desaulniers K, Gehring K, McKinney RA, Shoubridge EA, McPherson PS, Durham HD, Brais B. Sacs knockout mice present pathophysiological defects underlying autosomal recessive spastic ataxia of Charlevoix-Saguenay. Human Molecular Genetics. 24: 727-39. PMID 25260547 DOI: 10.1093/hmg/ddu491  0.56
2014 Gagnon C, Lavoie C, Lessard I, Mathieu J, Brais B, Bouchard JP, Fluet MC, Gassert R, Lambercy O. The Virtual Peg Insertion Test as an assessment of upper limb coordination in ARSACS patients: a pilot study. Journal of the Neurological Sciences. 347: 341-4. PMID 25439167 DOI: 10.1016/j.jns.2014.09.032  0.56
2014 Piana RL, Vanasse M, Brais B, Bernard G. Myelination Delay and Allan-Herndon-Dudley Syndrome Caused by a Novel Mutation in the SLC16A2 Gene. Journal of Child Neurology. PMID 25380603 DOI: 10.1177/0883073814555189  0.56
2014 La Piana R, Tran LT, Guerrero K, Brais B, Levesque S, Sébire G, Riou E, Bernard G. Spastic paraparesis and marked improvement of leukoencephalopathy in Aicardi-Goutières syndrome. Neuropediatrics. 45: 406-10. PMID 25343331 DOI: 10.1055/s-0034-1393710  0.56
2014 Robinson MÈ, Rossignol E, Brais B, Rouleau G, Arbour JF, Bernard G. Vanishing white matter disease in French-Canadian patients from Quebec. Pediatric Neurology. 51: 225-32. PMID 25079571 DOI: 10.1016/j.pediatrneurol.2014.05.006  0.56
2014 La Piana R, Webber A, Guiot MC, Del Pilar Cortes M, Brais B. A novel mutation in the CSF1R gene causes a variable leukoencephalopathy with spheroids. Neurogenetics. 15: 289-94. PMID 25012610 DOI: 10.1007/s10048-014-0413-1  0.56
2014 Srour M, Putorti ML, Schwartzentruber J, Bolduc V, Shevell MI, Poulin C, O'ferrall E, Buhas D, Majewski J, Brais B. Mutations in riboflavin transporter present with severe sensory loss and deafness in childhood. Muscle & Nerve. 50: 775-9. PMID 24616084 DOI: 10.1002/mus.24224  0.56
2014 La Piana R, Tonduti D, Gordish Dressman H, Schmidt JL, Murnick J, Brais B, Bernard G, Vanderver A. Brain magnetic resonance imaging (MRI) pattern recognition in Pol III-related leukodystrophies. Journal of Child Neurology. 29: 214-20. PMID 24105487 DOI: 10.1177/0883073813503902  0.56
2013 Blumen SC, Kesler A, Dabby R, Shalev S, Khayat M, Almog Y, Zoldan J, Benninger F, Drory VE, Gurevich M, Sadeh M, Brais B, Braverman I. Oculopharyngeal muscular dystrophy among Bulgarian Jews: a new cluster? The Israel Medical Association Journal : Imaj. 15: 748-52. PMID 24449978 DOI: 10.1007/978-1-4614-6567-6_60  0.44
2013 Abu-Baker A, Laganiere J, Gaudet R, Rochefort D, Brais B, Neri C, Dion PA, Rouleau GA. Lithium chloride attenuates cell death in oculopharyngeal muscular dystrophy by perturbing Wnt/β-catenin pathway. Cell Death & Disease. 4: e821. PMID 24091664 DOI: 10.1038/cddis.2013.342  0.56
2013 Duquette A, Brais B, Bouchard JP, Mathieu J. Clinical presentation and early evolution of spastic ataxia of Charlevoix-Saguenay. Movement Disorders : Official Journal of the Movement Disorder Society. 28: 2011-4. PMID 23913799 DOI: 10.1002/mds.25604  0.56
2013 Raz V, Butler-Browne G, van Engelen B, Brais B. 191st ENMC international workshop: recent advances in oculopharyngeal muscular dystrophy research: from bench to bedside 8-10 June 2012, Naarden, The Netherlands. Neuromuscular Disorders : Nmd. 23: 516-23. PMID 23578714 DOI: 10.1016/j.nmd.2013.03.001  0.56
2013 Daoud H, Tétreault M, Gibson W, Guerrero K, Cohen A, Gburek-Augustat J, Synofzik M, Brais B, Stevens CA, Sanchez-Carpintero R, Goizet C, Naidu S, Vanderver A, Bernard G. Mutations in POLR3A and POLR3B are a major cause of hypomyelinating leukodystrophies with or without dental abnormalities and/or hypogonadotropic hypogonadism. Journal of Medical Genetics. 50: 194-7. PMID 23355746 DOI: 10.1136/jmedgenet-2012-101357  0.56
2013 Thiffault I, Dicaire MJ, Tetreault M, Huang KN, Demers-Lamarche J, Bernard G, Duquette A, Larivière R, Gehring K, Montpetit A, McPherson PS, Richter A, Montermini L, Mercier J, Mitchell GA, ... ... Brais B, et al. Diversity of ARSACS mutations in French-Canadians. The Canadian Journal of Neurological Sciences. Le Journal Canadien Des Sciences Neurologiques. 40: 61-6. PMID 23250129  0.56
2012 Potic A, Brais B, Choquet K, Schiffmann R, Bernard G. 4H syndrome with late-onset growth hormone deficiency caused by POLR3A mutations. Archives of Neurology. 69: 920-3. PMID 22451160 DOI: 10.1001/archneurol.2011.1963  0.56
2012 Bayat V, Thiffault I, Jaiswal M, Tétreault M, Donti T, Sasarman F, Bernard G, Demers-Lamarche J, Dicaire MJ, Mathieu J, Vanasse M, Bouchard JP, Rioux MF, Lourenco CM, Li Z, ... ... Brais B, et al. Mutations in the mitochondrial methionyl-tRNA synthetase cause a neurodegenerative phenotype in flies and a recessive ataxia (ARSAL) in humans. Plos Biology. 10: e1001288. PMID 22448145 DOI: 10.1371/journal.pbio.1001288  0.56
2012 Tétreault M, Putorti ML, Thiffault I, Sylvain M, Venderver A, Schiffmann R, Brais B, Bernard G. TACH leukodystrophy: locus refinement to chromosome 10q22.3-23.1. The Canadian Journal of Neurological Sciences. Le Journal Canadien Des Sciences Neurologiques. 39: 122-3. PMID 22384513  0.56
2012 Noreau A, Dion PA, Szuto A, Levert A, Thibodeau P, Brais B, Dupré N, Rioux MF, Rouleau GA. CYP7B1 mutations in French-Canadian hereditary spastic paraplegia subjects. The Canadian Journal of Neurological Sciences. Le Journal Canadien Des Sciences Neurologiques. 39: 91-4. PMID 22384504  0.56
2012 La Piana R, Vanderver A, van der Knaap M, Roux L, Tampieri D, Brais B, Bernard G. Adult-onset vanishing white matter disease due to a novel EIF2B3 mutation. Archives of Neurology. 69: 765-68. PMID 22312164 DOI: 10.1001/archneurol.2011.1942  0.56
2012 Girard M, Larivière R, Parfitt DA, Deane EC, Gaudet R, Nossova N, Blondeau F, Prenosil G, Vermeulen EG, Duchen MR, Richter A, Shoubridge EA, Gehring K, McKinney RA, Brais B, et al. Mitochondrial dysfunction and Purkinje cell loss in autosomal recessive spastic ataxia of Charlevoix-Saguenay (ARSACS). Proceedings of the National Academy of Sciences of the United States of America. 109: 1661-6. PMID 22307627 DOI: 10.1073/pnas.1113166109  0.56
2012 Belzil VV, Langlais JS, Daoud H, Dion PA, Brais B, Rouleau GA. Novel FUS deletion in a patient with juvenile amyotrophic lateral sclerosis. Archives of Neurology. 69: 653-6. PMID 22248478 DOI: 10.1001/archneurol.2011.2499  0.56
2011 Tétreault M, Choquet K, Orcesi S, Tonduti D, Balottin U, Teichmann M, Fribourg S, Schiffmann R, Brais B, Vanderver A, Bernard G. Recessive mutations in POLR3B, encoding the second largest subunit of Pol III, cause a rare hypomyelinating leukodystrophy. American Journal of Human Genetics. 89: 652-5. PMID 22036172 DOI: 10.1016/j.ajhg.2011.10.006  0.56
2011 Tétreault M, Srour M, Allyson J, Thiffault I, Loisel L, Robitaille Y, Bouchard JP, Brais B. Founder mutation for α-sarcoglycan-LGMD2D in a Magdalen Islands Acadian cluster. The Canadian Journal of Neurological Sciences. Le Journal Canadien Des Sciences Neurologiques. 38: 747-52. PMID 21856579  0.56
2011 Bernard G, Chouery E, Putorti ML, Tétreault M, Takanohashi A, Carosso G, Clément I, Boespflug-Tanguy O, Rodriguez D, Delague V, Abou Ghoch J, Jalkh N, Dorboz I, Fribourg S, Teichmann M, ... ... Brais B, et al. Mutations of POLR3A encoding a catalytic subunit of RNA polymerase Pol III cause a recessive hypomyelinating leukodystrophy. American Journal of Human Genetics. 89: 415-23. PMID 21855841 DOI: 10.1016/j.ajhg.2011.07.014  0.56
2011 Rivière JB, Ramalingam S, Lavastre V, Shekarabi M, Holbert S, Lafontaine J, Srour M, Merner N, Rochefort D, Hince P, Gaudet R, Mes-Masson AM, Baets J, Houlden H, Brais B, et al. KIF1A, an axonal transporter of synaptic vesicles, is mutated in hereditary sensory and autonomic neuropathy type 2. American Journal of Human Genetics. 89: 219-30. PMID 21820098 DOI: 10.1016/j.ajhg.2011.06.013  0.56
2011 Kozlov G, Denisov AY, Girard M, Dicaire MJ, Hamlin J, McPherson PS, Brais B, Gehring K. Structural basis of defects in the sacsin HEPN domain responsible for autosomal recessive spastic ataxia of Charlevoix-Saguenay (ARSACS). The Journal of Biological Chemistry. 286: 20407-12. PMID 21507954 DOI: 10.1074/jbc.M111.232884  0.56
2011 Brais B. Oculopharyngeal muscular dystrophy. Handbook of Clinical Neurology. 101: 181-92. PMID 21496634 DOI: 10.1016/B978-0-08-045031-5.00014-1  0.56
2011 Valdmanis PN, Dupré N, Lachance M, Stochmanski SJ, Belzil VV, Dion PA, Thiffault I, Brais B, Weston L, Saint-Amant L, Samuels ME, Rouleau GA. A mutation in the RNF170 gene causes autosomal dominant sensory ataxia. Brain : a Journal of Neurology. 134: 602-7. PMID 21115467 DOI: 10.1093/brain/awq329  0.56
2010 Rajadhyaksha AM, Elemento O, Puffenberger EG, Schierberl KC, Xiang JZ, Putorti ML, Berciano J, Poulin C, Brais B, Michaelides M, Weleber RG, Higgins JJ. Mutations in FLVCR1 cause posterior column ataxia and retinitis pigmentosa. American Journal of Human Genetics. 87: 643-54. PMID 21070897 DOI: 10.1016/j.ajhg.2010.10.013  0.56
2010 Lafrenière RG, Cader MZ, Poulin JF, Andres-Enguix I, Simoneau M, Gupta N, Boisvert K, Lafrenière F, McLaughlan S, Dubé MP, Marcinkiewicz MM, Ramagopalan S, Ansorge O, Brais B, Sequeiros J, et al. A dominant-negative mutation in the TRESK potassium channel is linked to familial migraine with aura. Nature Medicine. 16: 1157-60. PMID 20871611 DOI: 10.1038/nm.2216  0.56
2010 Bernard G, Thiffault I, Tetreault M, Putorti ML, Bouchard I, Sylvain M, Melançon S, Laframboise R, Langevin P, Bouchard JP, Vanasse M, Vanderver A, Sébire G, Brais B. Tremor-ataxia with central hypomyelination (TACH) leukodystrophy maps to chromosome 10q22.3-10q23.31. Neurogenetics. 11: 457-64. PMID 20640464 DOI: 10.1007/s10048-010-0251-8  0.56
2010 Srour M, Bolduc V, Guergueltcheva V, Lochmüller H, Gendron D, Shevell MI, Poulin C, Mathieu J, Bouchard JP, Brais B. DOK7 mutations presenting as a proximal myopathy in French Canadians. Neuromuscular Disorders : Nmd. 20: 453-7. PMID 20610155 DOI: 10.1016/j.nmd.2010.05.007  0.56
2010 Pasco MY, Catoire H, Parker JA, Brais B, Rouleau GA, Néri C. Cross-talk between canonical Wnt signaling and the sirtuin-FoxO longevity pathway to protect against muscular pathology induced by mutant PABPN1 expression in C. elegans. Neurobiology of Disease. 38: 425-33. PMID 20227501 DOI: 10.1016/j.nbd.2010.03.002  0.56
2010 Bolduc V, Marlow G, Boycott KM, Saleki K, Inoue H, Kroon J, Itakura M, Robitaille Y, Parent L, Baas F, Mizuta K, Kamata N, Richard I, Linssen WH, Mahjneh I, ... ... Brais B, et al. Recessive mutations in the putative calcium-activated chloride channel Anoctamin 5 cause proximal LGMD2L and distal MMD3 muscular dystrophies. American Journal of Human Genetics. 86: 213-21. PMID 20096397 DOI: 10.1016/j.ajhg.2009.12.013  0.56
2009 Blumen SC, Bouchard JP, Brais B, Carasso RL, Paleacu D, Drory VE, Chantal S, Blumen N, Braverman I. Cognitive impairment and reduced life span of oculopharyngeal muscular dystrophy homozygotes. Neurology. 73: 596-601. PMID 19704078 DOI: 10.1212/WNL.0b013e3181b388a3  0.56
2009 Loggia ML, Bushnell MC, Tétreault M, Thiffault I, Bhérer C, Mohammed NK, Kuchinad AA, Laferrière A, Dicaire MJ, Loisel L, Mogil JS, Brais B. Carriers of recessive WNK1/HSN2 mutations for hereditary sensory and autonomic neuropathy type 2 (HSAN2) are more sensitive to thermal stimuli. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 29: 2162-6. PMID 19228968 DOI: 10.1523/JNEUROSCI.4633-08.2009  0.56
2009 Brais B. Oculopharyngeal muscular dystrophy: a polyalanine myopathy. Current Neurology and Neuroscience Reports. 9: 76-82. PMID 19080757 DOI: 10.1007/s11910-009-0012-y  0.56
2009 Dupré N, Chrestian N, Bouchard JP, Rossignol E, Brunet D, Sternberg D, Brais B, Mathieu J, Puymirat J. Clinical, electrophysiologic, and genetic study of non-dystrophic myotonia in French-Canadians. Neuromuscular Disorders : Nmd. 19: 330-4. PMID 18337100 DOI: 10.1016/j.nmd.2008.01.007  0.56
2008 Gosselin I, Thiffault I, Tétreault M, Chau V, Dicaire MJ, Loisel L, Emond M, Senderek J, Mathieu J, Dupré N, Vanasse M, Puymirat J, Brais B. Founder SH3TC2 mutations are responsible for a CMT4C French-Canadians cluster. Neuromuscular Disorders : Nmd. 18: 483-92. PMID 18511281 DOI: 10.1016/j.nmd.2008.04.001  0.56
2008 Catoire H, Pasco MY, Abu-Baker A, Holbert S, Tourette C, Brais B, Rouleau GA, Parker JA, Néri C. Sirtuin inhibition protects from the polyalanine muscular dystrophy protein PABPN1. Human Molecular Genetics. 17: 2108-17. PMID 18397876 DOI: 10.1093/hmg/ddn109  0.56
2008 Klein AF, Ebihara M, Alexander C, Dicaire MJ, Sasseville AM, Langelier Y, Rouleau GA, Brais B. PABPN1 polyalanine tract deletion and long expansions modify its aggregation pattern and expression. Experimental Cell Research. 314: 1652-66. PMID 18367172 DOI: 10.1016/j.yexcr.2008.02.005  0.56
2008 Dupré N, Chrestian N, Thiffault I, Brais B, Rouleau GA, Bouchard JP. [Hereditary ataxias, spastic parapareses and neuropathies in Eastern Canada]. Revue Neurologique. 164: 12-21. PMID 18342054 DOI: 10.1016/j.neurol.2007.08.006  0.56
2007 Rossignol E, Mathieu J, Thiffault I, Tétreault M, Dicaire MJ, Chrestian N, Dupré N, Puymirat J, Brais B. A novel founder SCN4A mutation causes painful cold-induced myotonia in French-Canadians. Neurology. 69: 1937-41. PMID 17998485 DOI: 10.1212/01.wnl.0000290831.08585.2c  0.56
2007 Nahas SA, Duquette A, Roddier K, Gatti RA, Brais B. Ataxia-oculomotor apraxia 2 patients show no increased sensitivity to ionizing radiation. Neuromuscular Disorders : Nmd. 17: 968-9. PMID 17720498 DOI: 10.1016/j.nmd.2007.06.464  0.56
2007 Meijer IA, Dupré N, Brais B, Cossette P, St-Onge J, Rioux MF, Benard M, Rouleau GA. SPG4 founder effect in French Canadians with hereditary spastic paraplegia. The Canadian Journal of Neurological Sciences. Le Journal Canadien Des Sciences Neurologiques. 34: 211-4. PMID 17598600  0.56
2007 Dupré N, Gros-Louis F, Chrestian N, Verreault S, Brunet D, de Verteuil D, Brais B, Bouchard JP, Rouleau GA. Clinical and genetic study of autosomal recessive cerebellar ataxia type 1. Annals of Neurology. 62: 93-8. PMID 17503513 DOI: 10.1002/ana.21143  0.56
2007 Meijer IA, Dion P, Laurent S, Dupré N, Brais B, Levert A, Puymirat J, Rioux MF, Sylvain M, Zhu PP, Soderblom C, Stadler J, Blackstone C, Rouleau GA. Characterization of a novel SPG3A deletion in a French-Canadian family. Annals of Neurology. 61: 599-603. PMID 17427918 DOI: 10.1002/ana.21114  0.56
2007 Messaed C, Dion PA, Abu-Baker A, Rochefort D, Laganiere J, Brais B, Rouleau GA. Soluble expanded PABPN1 promotes cell death in oculopharyngeal muscular dystrophy. Neurobiology of Disease. 26: 546-57. PMID 17418585 DOI: 10.1016/j.nbd.2007.02.004  0.56
2007 Jarry J, Rioux MF, Bolduc V, Robitaille Y, Khoury V, Thiffault I, Tétreault M, Loisel L, Bouchard JP, Brais B. A novel autosomal recessive limb-girdle muscular dystrophy with quadriceps atrophy maps to 11p13-p12. Brain : a Journal of Neurology. 130: 368-80. PMID 17008331 DOI: 10.1093/brain/awl270  0.56
2007 Bouchard JP, Brais B, Dupré N, Rouleau GA. Chapter 9 Hereditary Ataxias and Spastic Parapareses in Northeastern Canada Blue Books of Neurology. 31: 222-243. DOI: 10.1016/S1877-184X(09)70083-8  0.56
2006 Marie-Josée Sasseville A, Caron AW, Bourget L, Klein AF, Dicaire MJ, Rouleau GA, Massie B, Langelier Y, Brais B. The dynamism of PABPN1 nuclear inclusions during the cell cycle. Neurobiology of Disease. 23: 621-9. PMID 16860991 DOI: 10.1016/j.nbd.2006.05.015  0.56
2006 Tétreault M, Duquette A, Thiffault I, Bherer C, Jarry J, Loisel L, Banwell B, D'Anjou G, Mathieu J, Robitaille Y, Vanasse M, Brais B. A new form of congenital muscular dystrophy with joint hyperlaxity maps to 3p23-21. Brain : a Journal of Neurology. 129: 2077-84. PMID 16760198 DOI: 10.1093/brain/awl146  0.56
2006 Dupré N, Bouchard JP, Brais B, Rouleau GA. Hereditary ataxia, spastic paraparesis and neuropathy in the French-Canadian population. The Canadian Journal of Neurological Sciences. Le Journal Canadien Des Sciences Neurologiques. 33: 149-57. PMID 16736723  0.56
2006 Thiffault I, Rioux MF, Tetreault M, Jarry J, Loiselle L, Poirier J, Gros-Louis F, Mathieu J, Vanasse M, Rouleau GA, Bouchard JP, Lesage J, Brais B. A new autosomal recessive spastic ataxia associated with frequent white matter changes maps to 2q33-34. Brain : a Journal of Neurology. 129: 2332-40. PMID 16672289 DOI: 10.1093/brain/awl110  0.56
2005 Laberge AM, Michaud J, Richter A, Lemyre E, Lambert M, Brais B, Mitchell GA. Population history and its impact on medical genetics in Quebec. Clinical Genetics. 68: 287-301. PMID 16143014 DOI: 10.1111/j.1399-0004.2005.00497.x  0.56
2005 Abu-Baker A, Laganiere S, Fan X, Laganiere J, Brais B, Rouleau GA. Cytoplasmic targeting of mutant poly(A)-binding protein nuclear 1 suppresses protein aggregation and toxicity in oculopharyngeal muscular dystrophy. Traffic (Copenhagen, Denmark). 6: 766-79. PMID 16101680 DOI: 10.1111/j.1600-0854.2005.00315.x  0.56
2005 Laberge AM, Jomphe M, Houde L, Vezina H, Tremblay M, Desjardins B, Labuda D, St-Hilaire M, Macmillan C, Shoubridge EA, Brais B. A "Fille du Roy" introduced the T14484C Leber hereditary optic neuropathy mutation in French Canadians. American Journal of Human Genetics. 77: 313-7. PMID 15954041 DOI: 10.1086/432491  0.56
2005 Roddier K, Thomas T, Marleau G, Gagnon AM, Dicaire MJ, St-Denis A, Gosselin I, Sarrazin AM, Larbrisseau A, Lambert M, Vanasse M, Gaudet D, Rouleau GA, Brais B. Two mutations in the HSN2 gene explain the high prevalence of HSAN2 in French Canadians. Neurology. 64: 1762-7. PMID 15911806 DOI: 10.1212/01.WNL.0000161849.29944.43  0.56
2005 Corbeil-Girard LP, Klein AF, Sasseville AM, Lavoie H, Dicaire MJ, Saint-Denis A, Pagé M, Duranceau A, Codère F, Bouchard JP, Karpati G, Rouleau GA, Massie B, Langelier Y, Brais B. PABPN1 overexpression leads to upregulation of genes encoding nuclear proteins that are sequestered in oculopharyngeal muscular dystrophy nuclear inclusions. Neurobiology of Disease. 18: 551-67. PMID 15755682 DOI: 10.1016/j.nbd.2004.10.019  0.56
2005 Dion P, Shanmugam V, Gaspar C, Messaed C, Meijer I, Toulouse A, Laganiere J, Roussel J, Rochefort D, Laganiere S, Allen C, Karpati G, Bouchard JP, Brais B, Rouleau GA. Transgenic expression of an expanded (GCG)13 repeat PABPN1 leads to weakness and coordination defects in mice. Neurobiology of Disease. 18: 528-36. PMID 15755680 DOI: 10.1016/j.nbd.2004.09.021  0.56
2005 Duquette A, Roddier K, McNabb-Baltar J, Gosselin I, St-Denis A, Dicaire MJ, Loisel L, Labuda D, Marchand L, Mathieu J, Bouchard JP, Brais B. Mutations in senataxin responsible for Quebec cluster of ataxia with neuropathy. Annals of Neurology. 57: 408-14. PMID 15732101 DOI: 10.1002/ana.20408  0.56
2005 Rodríguez M, Camejo C, Bertoni B, Braida C, Rodríguez MM, Brais B, Medici M, Roche L. (GCG)11 founder mutation in the PABPN1 gene of OPMD Uruguayan families. Neuromuscular Disorders : Nmd. 15: 185-90. PMID 15694141 DOI: 10.1016/j.nmd.2004.10.012  0.56
2005 Caron MJ, Girard F, Girard DC, Boudreault D, Brais B, Nassif E, Chouinard P, Ruel M, Duranceau A. Cisatracurium pharmacodynamics in patients with oculopharyngeal muscular dystrophy. Anesthesia and Analgesia. 100: 393-7. PMID 15673864 DOI: 10.1213/01.ANE.0000140783.39597.FD  0.56
2004 Pou Serradell A, Lloreta Trull J, Corominas Torres JM, Hammouda EH, Urtizberea JA, Richard P, Brais B. [Oculopharyngeal muscular dystrophy: study of patients from seven Spanish families with different GCG expansions in PABP2 gene]. Neurología (Barcelona, Spain). 19: 239-47. PMID 15150706  0.56
2004 Lafreniere RG, MacDonald ML, Dube MP, MacFarlane J, O'Driscoll M, Brais B, Meilleur S, Brinkman RR, Dadivas O, Pape T, Platon C, Radomski C, Risler J, Thompson J, Guerra-Escobio AM, et al. Identification of a novel gene (HSN2) causing hereditary sensory and autonomic neuropathy type II through the Study of Canadian Genetic Isolates. American Journal of Human Genetics. 74: 1064-73. PMID 15060842 DOI: 10.1086/420795  0.56
2003 Brais B. Oculopharyngeal muscular dystrophy: a late-onset polyalanine disease. Cytogenetic and Genome Research. 100: 252-60. PMID 14526187 DOI: 10.1159/000072861  0.56
2003 Lavoie H, Debeane F, Trinh QD, Turcotte JF, Corbeil-Girard LP, Dicaire MJ, Saint-Denis A, Pagé M, Rouleau GA, Brais B. Polymorphism, shared functions and convergent evolution of genes with sequences coding for polyalanine domains. Human Molecular Genetics. 12: 2967-79. PMID 14519685 DOI: 10.1093/hmg/ddg329  0.56
2003 Stumpf E, Masson H, Duquette A, Berthelet F, McNabb J, Lortie A, Lesage J, Montplaisir J, Brais B, Cossette P. Adult Alexander disease with autosomal dominant transmission: a distinct entity caused by mutation in the glial fibrillary acid protein gene. Archives of Neurology. 60: 1307-12. PMID 12975300 DOI: 10.1001/archneur.60.9.1307  0.56
2003 Fan X, Messaed C, Dion P, Laganiere J, Brais B, Karpati G, Rouleau GA. HnRNP A1 and A/B interaction with PABPN1 in oculopharyngeal muscular dystrophy. The Canadian Journal of Neurological Sciences. Le Journal Canadien Des Sciences Neurologiques. 30: 244-51. PMID 12945950  0.56
2003 Abu-Baker A, Messaed C, Laganiere J, Gaspar C, Brais B, Rouleau GA. Involvement of the ubiquitin-proteasome pathway and molecular chaperones in oculopharyngeal muscular dystrophy. Human Molecular Genetics. 12: 2609-23. PMID 12944420 DOI: 10.1093/hmg/ddg293  0.56
2001 Codère F, Brais B, Rouleau G, Lafontaine E. Oculopharyngeal muscular dystrophy: What's new? Orbit (Amsterdam, Netherlands). 20: 259-266. PMID 12045902 DOI: 10.1076/orbi.  0.56
2001 Fan X, Dion P, Laganiere J, Brais B, Rouleau GA. Oligomerization of polyalanine expanded PABPN1 facilitates nuclear protein aggregation that is associated with cell death. Human Molecular Genetics. 10: 2341-51. PMID 11689481  0.56
2000 Blumen SC, Korczyn AD, Lavoie H, Medynski S, Chapman J, Asherov A, Nisipeanu P, Inzelberg R, Carasso RL, Bouchard JP, Tomé FM, Rouleau GA, Brais B. Oculopharyngeal MD among Bukhara Jews is due to a founder (GCG)9 mutation in the PABP2 gene. Neurology. 55: 1267-70. PMID 11087766  0.56
2000 Shanmugam V, Dion P, Rochefort D, Laganière J, Brais B, Rouleau GA. PABP2 polyalanine tract expansion causes intranuclear inclusions in oculopharyngeal muscular dystrophy. Annals of Neurology. 48: 798-802. PMID 11079546 DOI: 10.1002/1531-8249(200011)48:5<798::AID-ANA16>3.0.CO;2-U  0.56
2000 Calado A, Tomé FM, Brais B, Rouleau GA, Kühn U, Wahle E, Carmo-Fonseca M. Nuclear inclusions in oculopharyngeal muscular dystrophy consist of poly(A) binding protein 2 aggregates which sequester poly(A) RNA. Human Molecular Genetics. 9: 2321-8. PMID 11001936  0.56
2000 Gaspar C, Jannatipour M, Dion P, Laganière J, Sequeiros J, Brais B, Rouleau GA. CAG tract of MJD-1 may be prone to frameshifts causing polyalanine accumulation. Human Molecular Genetics. 9: 1957-66. PMID 10942424  0.56
1999 Brais B, Rouleau GA, Bouchard JP, Fardeau M, Tomé FM. Oculopharyngeal muscular dystrophy. Seminars in Neurology. 19: 59-66. PMID 10711989 DOI: 10.1055/s-2008-1040826  0.56
1999 Blumen SC, Brais B, Korczyn AD, Medinsky S, Chapman J, Asherov A, Nisipeanu P, Codère F, Bouchard JP, Fardeau M, Tomé FM, Rouleau GA. Homozygotes for oculopharyngeal muscular dystrophy have a severe form of the disease. Annals of Neurology. 46: 115-8. PMID 10401788 DOI: 10.1002/1531-8249(199907)46:1<115::AID-ANA17>3.0.CO;2-O  0.56
1999 Mezei MM, Mankodi A, Brais B, Marineau C, Thornton CA, Rouleau GA, Karpati G. Minimal expansion of the GCG repeat in the PABP2 gene does not predispose to sporadic inclusion body myositis. Neurology. 52: 669-70. PMID 10025815  0.56
1998 Feit H, Silbergleit A, Schneider LB, Gutierrez JA, Fitoussi RP, Réyès C, Rouleau GA, Brais B, Jackson CE, Beckmann JS, Seboun E. Vocal cord and pharyngeal weakness with autosomal dominant distal myopathy: clinical description and gene localization to 5q31. American Journal of Human Genetics. 63: 1732-42. PMID 9837826 DOI: 10.1086/302166  0.56
1998 Xie YG, Rochefort D, Brais B, Howard H, Han FY, Gou LP, Maciel P, The BT, Larsson C, Rouleau GA. Restriction map of a YAC and cosmid contig encompassing the oculopharyngeal muscular dystrophy candidate region on chromosome 14q11.2-q13. Genomics. 52: 201-4. PMID 9782086 DOI: 10.1006/geno.1998.5421  0.56
1998 Brais B, Bouchard JP, Xie YG, Rochefort DL, Chrétien N, Tomé FM, Lafrenière RG, Rommens JM, Uyama E, Nohira O, Blumen S, Korczyn AD, Heutink P, Mathieu J, Duranceau A, et al. Short GCG expansions in the PABP2 gene cause oculopharyngeal muscular dystrophy. Nature Genetics. 18: 164-7. PMID 9462747 DOI: 10.1038/ng0298-164  0.56
1997 Mathieu J, Lapointe G, Brassard A, Tremblay C, Brais B, Rouleau GA, Bouchard JP. A pilot study on upper esophageal sphincter dilatation for the treatment of dysphagia in patients with oculopharyngeal muscular dystrophy. Neuromuscular Disorders : Nmd. 7: S100-4. PMID 9392026 DOI: 10.1016/S0960-8966(97)00092-8  0.56
1997 Brais B, Bouchard JP, Gosselin F, Xie YG, Fardeau M, Tomé FM, Rouleau GA. Using the full power of linkage analysis in 11 French Canadian families to fine map the oculopharyngeal muscular dystrophy gene. Neuromuscular Disorders : Nmd. 7: S70-4. PMID 9392020 DOI: 10.1016/S0960-8966(97)00086-2  0.56
1997 Bouchard JP, Brais B, Brunet D, Gould PV, Rouleau GA. Recent studies on oculopharyngeal muscular dystrophy in Québec. Neuromuscular Disorders : Nmd. 7: S22-9. PMID 9392011 DOI: 10.1016/S0960-8966(97)00077-1  0.56
1997 Neetens A, Martin JJ, Brais B, Wein B, Dreuw B, Tijssen CC, Ceuterick C. Oculopharyngeal muscular dystrophy (OPMD) Neuro-Ophthalmology. 17: 189-200.  0.56
1996 Kibar Z, Der Kaloustian VM, Brais B, Hani V, Fraser FC, Rouleau GA. The gene responsible for Clouston hidrotic ectodermal dysplasia maps to the pericentromeric region of chromosome 13q. Human Molecular Genetics. 5: 543-7. PMID 8845850 DOI: 10.1093/hmg/5.4.543  0.56
1995 Brais B, Xie YG, Sanson M, Morgan K, Weissenbach J, Korczyn AD, Blumen SC, Fardeau M, Tomé FM, Bouchard JP. The oculopharyngeal muscular dystrophy locus maps to the region of the cardiac alpha and beta myosin heavy chain genes on chromosome 14q11.2-q13. Human Molecular Genetics. 4: 429-34. PMID 7795598 DOI: 10.1093/hmg/4.3.429  0.56
1993 Brais B. Jean Martin Charcot and aphasia: treading the line between experimental physiology and pathological anatomy. Brain and Language. 45: 511-30. PMID 8118671 DOI: 10.1006/brln.1993.1058  0.56
1993 Brais B. Désiré Magloire Bourneville and French anticlericalism during the Third Republic. Clio Medica (Amsterdam, Netherlands). 23: 107-39. PMID 7691464  0.56
1992 Brais B. The third left frontal convolution plays no role in language: Pierre Marie and the Paris debate on aphasia (1906-1908). Neurology. 42: 690-5. PMID 1549242 DOI: 10.1212/WNL.42.3.690  0.56
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