| Year |
Citation |
Score |
| 2023 |
Tikunova SB, Thuma J, Davis JP. Mouse Models of Cardiomyopathies Caused by Mutations in Troponin C. International Journal of Molecular Sciences. 24. PMID 37569724 DOI: 10.3390/ijms241512349 |
0.433 |
|
| 2023 |
Williams RB, Alam Afsar MN, Tikunova S, Kou Y, Fang X, Somarathne RP, Gyawu RF, Knotts GM, Agee TA, Garcia SA, Losordo LD, Fitzkee NC, Kekenes-Huskey PM, Davis JP, Johnson CN. Human disease-associated calmodulin mutations alter calcineurin function through multiple mechanisms. Cell Calcium. 113: 102752. PMID 37245392 DOI: 10.1016/j.ceca.2023.102752 |
0.393 |
|
| 2023 |
Hantz ER, Tikunova SB, Belevych N, Davis JP, Reiser PJ, Lindert S. Targeting Troponin C with Small Molecules Containing Diphenyl Moieties: Calcium Sensitivity Effects on Striated Muscles and Structure-Activity Relationship. Journal of Chemical Information and Modeling. PMID 37204863 DOI: 10.1021/acs.jcim.3c00196 |
0.406 |
|
| 2023 |
Hantz ER, Tikunova SB, Belevych N, Davis JP, Reiser PJ, Lindert S. Targeting Troponin C with Small Molecules Containing Diphenyl Moieties: Calcium Sensitivity Effects on Striated Muscle and Structure Activity Relationship. Biorxiv : the Preprint Server For Biology. PMID 36798160 DOI: 10.1101/2023.02.06.527323 |
0.409 |
|
| 2022 |
Mahmud Z, Tikunova S, Belevych N, Wagg CS, Zhabyeyev P, Liu PB, Rasicci DV, Yengo CM, Oudit GY, Lopaschuk GD, Reiser PJ, Davis JP, Hwang PM. Small Molecule RPI-194 Stabilizes Activated Troponin to Increase the Calcium Sensitivity of Striated Muscle Contraction. Frontiers in Physiology. 13: 892979. PMID 35755445 DOI: 10.3389/fphys.2022.892979 |
0.332 |
|
| 2020 |
Coldren WH, Tikunova SB, Davis JP, Lindert S. Discovery of Novel Small-Molecule Calcium Sensitizers for Cardiac Troponin C: A Combined Virtual and Experimental Screening Approach. Journal of Chemical Information and Modeling. PMID 32633957 DOI: 10.1021/Acs.Jcim.0C00452 |
0.475 |
|
| 2020 |
Bogdanov V, Tikunova S, Kou Y, Fadell N, Evans J, Tirone A, Hauck G, Johnson C, Lindert S, Gyorke S, Davis JP. In Silico Engineering of Calmodulin to Bind the Cardiac Ryanodine Receptor with High Affinity Biophysical Journal. 118: 594a. DOI: 10.1016/J.Bpj.2019.11.3215 |
0.366 |
|
| 2020 |
Hauck GT, Kou Y, Tikunova S, Davis JP. Mathematical Modeling of Calcium Binding to Human, Plant, and Engineered Calmodulin, as well as Cardiac and Slow Skeletal Troponin Biophysical Journal. 118. DOI: 10.1016/J.Bpj.2019.11.3069 |
0.424 |
|
| 2019 |
Sun B, Vaughan DM, Tikunova SB, Creamer TP, Davis JP, Kekenes-Huskey PM. Calmodulin/Calcineurin Interaction Beyond the Calmodulin-binding Region Contributes to Calcineurin Activation. Biochemistry. PMID 31483613 DOI: 10.1021/Acs.Biochem.9B00626 |
0.42 |
|
| 2019 |
Bowman J, Aprahamian M, Tikunova S, Davis JP, Lindert S. Virtual Screening Finds Troponin Calcium Sensitizers and Umbrella Sampling Simulations Elucidate Differences in Troponin C Isoform and Mutant Hydrophobic Patch Exposure Biophysical Journal. 116: 435a. DOI: 10.1016/J.Bpj.2018.11.2343 |
0.363 |
|
| 2018 |
Tikunova SB, Cuesta A, Price M, Li MX, Belevych N, Biesiadecki BJ, Reiser PJ, Hwang PM, Davis JP. 3-Chlorodiphenylamine activates cardiac troponin by a mechanism distinct from bepridil or TFP. The Journal of General Physiology. PMID 30442775 DOI: 10.1085/Jgp.201812131 |
0.502 |
|
| 2018 |
Tikunova S, Belevych N, Doan K, Reiser PJ. Desensitizing mouse cardiac troponin C to calcium converts slow muscle towards a fast muscle phenotype. The Journal of Physiology. 596: 4651-4663. PMID 29992562 DOI: 10.1113/JP276296 |
0.302 |
|
| 2018 |
Liu B, Walton SD, Ho HT, Belevych AE, Tikunova SB, Bonilla I, Shettigar V, Knollmann BC, Priori SG, Volpe P, Radwański PB, Davis JP, Györke S. Gene Transfer of Engineered Calmodulin Alleviates Ventricular Arrhythmias in a Calsequestrin-Associated Mouse Model of Catecholaminergic Polymorphic Ventricular Tachycardia. Journal of the American Heart Association. 7. PMID 29720499 DOI: 10.1161/Jaha.117.008155 |
0.354 |
|
| 2018 |
Tikunova S, Belevych N, Doan K, Reiser PJ. Desensitizing mouse cardiac troponin C to calcium converts slow muscle towards a fast muscle phenotype. The Journal of Physiology. 596: 4651-4663. DOI: 10.1113/Jp276296 |
0.436 |
|
| 2017 |
Aprahamian ML, Tikunova SB, Price MV, Cuesta AF, Davis JP, Lindert S. Successful Identification of Cardiac Troponin Calcium Sensitizers Using a Combination of Virtual Screening and ROC Analysis of Known Troponin C Binders. Journal of Chemical Information and Modeling. PMID 29144742 DOI: 10.1021/acs.jcim.7b00536 |
0.478 |
|
| 2017 |
Walton SD, Chakravarthy H, Shettigar V, O'Neil AJ, Siddiqui JK, Jones BR, Tikunova SB, Davis JP. Divergent Soybean Calmodulins Respond Similarly to Calcium Transients: Insight into Differential Target Regulation. Frontiers in Plant Science. 8: 208. PMID 28261258 DOI: 10.3389/Fpls.2017.00208 |
0.41 |
|
| 2017 |
Tikunova S, Gyorke S, Brozovich F, Biesiadecki B, Janssen P, Ziolo M, Davis J. Designing Calcium Binding Proteins as Therapeutics against Muscle Diseases Biophysical Journal. 112: 425a. DOI: 10.1016/J.Bpj.2016.11.2270 |
0.418 |
|
| 2016 |
Siddiqui JK, Tikunova SB, Walton SD, Liu B, Meyer M, de Tombe PP, Neilson N, Kekenes-Huskey PM, Salhi HE, Janssen PM, Biesiadecki BJ, Davis JP. Myofilament Calcium Sensitivity: Consequences of the Effective Concentration of Troponin I. Frontiers in Physiology. 7: 632. PMID 28066265 DOI: 10.3389/Fphys.2016.00632 |
0.503 |
|
| 2016 |
Davis JP, Shettigar V, Tikunova SB, Little SC, Liu B, Siddiqui JK, Janssen PM, Ziolo MT, Walton SD. Designing Proteins to Combat Disease: Cardiac Troponin C as an Example. Archives of Biochemistry and Biophysics. PMID 26901433 DOI: 10.1016/J.Abb.2016.02.007 |
0.427 |
|
| 2016 |
Reiser PJ, Belevych N, Tikunova S. Consequences of Reduced Troponin-C Calcium Binding Affinity on Slow Skeletal Muscle Biophysical Journal. 110. DOI: 10.1016/J.Bpj.2015.11.1498 |
0.391 |
|
| 2015 |
McConnell BK, Singh S, Fan Q, Hernandez A, Portillo JP, Reiser PJ, Tikunova SB. Knock-in mice harboring a Ca(2+) desensitizing mutation in cardiac troponin C develop early onset dilated cardiomyopathy. Frontiers in Physiology. 6: 242. PMID 26379556 DOI: 10.3389/Fphys.2015.00242 |
0.451 |
|
| 2014 |
Swindle N, Albury AN, Baroud B, Burney M, Tikunova SB. Molecular and functional consequences of mutations in the central helix of cardiac troponin C. Archives of Biochemistry and Biophysics. 548: 46-53. PMID 24650606 DOI: 10.1016/J.Abb.2014.03.004 |
0.462 |
|
| 2013 |
Swindle N, Albury A, Tikunova S. Effect of cTnC Mutations on the Response of Reconstituted Thin Filaments to Calcium Upon cTnI Phosphorylation Biophysical Journal. 104: 311a. DOI: 10.1016/J.Bpj.2012.11.1729 |
0.47 |
|
| 2012 |
Liu B, Tikunova SB, Kline KP, Siddiqui JK, Davis JP. Disease-related cardiac troponins alter thin filament Ca2+ association and dissociation rates. Plos One. 7: e38259. PMID 22675533 DOI: 10.1371/Journal.Pone.0038259 |
0.516 |
|
| 2012 |
Liu B, Lee RS, Biesiadecki BJ, Tikunova SB, Davis JP. Engineered troponin C constructs correct disease-related cardiac myofilament calcium sensitivity. The Journal of Biological Chemistry. 287: 20027-36. PMID 22511780 DOI: 10.1074/Jbc.M111.334953 |
0.516 |
|
| 2012 |
Albury AN, Swindle N, Swartz DR, Tikunova SB. Effect of hypertrophic cardiomyopathy-linked troponin C mutations on the response of reconstituted thin filaments to calcium upon troponin I phosphorylation. Biochemistry. 51: 3614-21. PMID 22489623 DOI: 10.1021/Bi300187K |
0.462 |
|
| 2012 |
Albury A, Swindle N, Tikunova S. Effect of Hypertrophic Cardiomyopathy Linked Troponin C Mutations on the Calcium Sensitivity of Acto-Myosin ATPase under Different Phosphorylation States of Troponin I Biophysical Journal. 102: 156a. DOI: 10.1016/J.Bpj.2011.11.851 |
0.473 |
|
| 2011 |
Little SC, Tikunova SB, Norman C, Swartz DR, Davis JP. Measurement of calcium dissociation rates from troponin C in rigor skeletal myofibrils. Frontiers in Physiology. 2: 70. PMID 22013424 DOI: 10.3389/Fphys.2011.00070 |
0.482 |
|
| 2011 |
Albury A, Swindle N, Swartz DR, Tikunova S. Effect of Hypertrophic Cardiomyopathy Linked Troponin C Mutations and Troponin I Phosphorylation on the Rate of Calcium Dissociation from the Thin Filament Biophysical Journal. 100: 114a. DOI: 10.1016/J.Bpj.2010.12.833 |
0.453 |
|
| 2010 |
Lee RS, Tikunova SB, Kline KP, Zot HG, Hasbun JE, Minh NV, Swartz DR, Rall JA, Davis JP. Effect of Ca2+ binding properties of troponin C on rate of skeletal muscle force redevelopment. American Journal of Physiology. Cell Physiology. 299: C1091-9. PMID 20702687 DOI: 10.1152/Ajpcell.00491.2009 |
0.466 |
|
| 2010 |
Swindle N, Tikunova SB. Hypertrophic cardiomyopathy-linked mutation D145E drastically alters calcium binding by the C-domain of cardiac troponin C. Biochemistry. 49: 4813-20. PMID 20459070 DOI: 10.1021/Bi100400H |
0.512 |
|
| 2010 |
Tikunova SB, Liu B, Swindle N, Little SC, Gomes AV, Swartz DR, Davis JP. Effect of calcium-sensitizing mutations on calcium binding and exchange with troponin C in increasingly complex biochemical systems. Biochemistry. 49: 1975-84. PMID 20128626 DOI: 10.1021/Bi901867S |
0.495 |
|
| 2010 |
Tikunova S, Swindle NG. Effect of D145E Mutation on Calcium Binding and Exchange with the C-Domain of Troponin C Biophysical Journal. 98. DOI: 10.1016/J.Bpj.2009.12.808 |
0.506 |
|
| 2010 |
Liu B, Lee RS, Rall JA, Tikunova SB, Davis JP. Abnormal Thin Filament Calcium Binding Associated with Cardiac Muscle Diseases Can be Corrected Through TnC Mutagenesis Biophysical Journal. 98: 356a. DOI: 10.1016/J.Bpj.2009.12.1921 |
0.546 |
|
| 2009 |
Liu B, Little SC, Lee RS, Kline KP, Swartz D, Tikunova SB, Davis JP. The Rate Of Calcium Dissociation From The Cardiac Thin Filament Is Affected By Multiple Modulatory Factors Biophysical Journal. 96: 503a-504a. DOI: 10.1016/J.Bpj.2008.12.2595 |
0.507 |
|
| 2008 |
Liang B, Chung F, Qu Y, Pavlov D, Gillis TE, Tikunova SB, Davis JP, Tibbits GF. Familial hypertrophic cardiomyopathy-related cardiac troponin C mutation L29Q affects Ca2+ binding and myofilament contractility. Physiological Genomics. 33: 257-66. PMID 18285522 DOI: 10.1152/Physiolgenomics.00154.2007 |
0.535 |
|
| 2008 |
Davis JP, Tikunova SB. Ca(2+) exchange with troponin C and cardiac muscle dynamics. Cardiovascular Research. 77: 619-26. PMID 18079104 DOI: 10.1093/Cvr/Cvm098 |
0.465 |
|
| 2007 |
Norman C, Rall JA, Tikunova SB, Davis JP. Modulation of the rate of cardiac muscle contraction by troponin C constructs with various calcium binding affinities. American Journal of Physiology. Heart and Circulatory Physiology. 293: H2580-7. PMID 17693547 DOI: 10.1152/Ajpheart.00039.2007 |
0.49 |
|
| 2007 |
Kreutziger KL, Gillis TE, Davis JP, Tikunova SB, Regnier M. Influence of enhanced troponin C Ca2+-binding affinity on cooperative thin filament activation in rabbit skeletal muscle. The Journal of Physiology. 583: 337-50. PMID 17584846 DOI: 10.1113/Jphysiol.2007.135426 |
0.512 |
|
| 2007 |
Davis JP, Norman C, Kobayashi T, Solaro RJ, Swartz DR, Tikunova SB. Effects of thin and thick filament proteins on calcium binding and exchange with cardiac troponin C. Biophysical Journal. 92: 3195-206. PMID 17293397 DOI: 10.1529/Biophysj.106.095406 |
0.558 |
|
| 2006 |
Engel PL, Kobayashi T, Biesiadecki B, Davis J, Tikunova S, Wu S, Solaro RJ. Identification of a region of troponin I important in signaling cross-bridge-dependent activation of cardiac myofilaments. The Journal of Biological Chemistry. 282: 183-93. PMID 17099250 DOI: 10.1074/Jbc.M512337200 |
0.364 |
|
| 2006 |
Swartz DR, Yang Z, Sen A, Tikunova SB, Davis JP. Myofibrillar troponin exists in three states and there is signal transduction along skeletal myofibrillar thin filaments. Journal of Molecular Biology. 361: 420-35. PMID 16857209 DOI: 10.1016/J.Jmb.2006.05.078 |
0.404 |
|
| 2006 |
Fidalgo da Silva E, Freire MM, Barrabin H, Sorenson MM, Tikunova S, Johnson JD, Chandra M, Pearlstone JR, Scofano HM. Troponin C/calmodulin chimeras as erythrocyte plasma membrane Ca2+-ATPase activators. The International Journal of Biochemistry & Cell Biology. 38: 209-21. PMID 16213185 DOI: 10.1016/J.Biocel.2005.08.016 |
0.479 |
|
| 2004 |
Gomes AV, Venkatraman G, Davis JP, Tikunova SB, Engel P, Solaro RJ, Potter JD. Cardiac troponin T isoforms affect the Ca(2+) sensitivity of force development in the presence of slow skeletal troponin I: insights into the role of troponin T isoforms in the fetal heart. The Journal of Biological Chemistry. 279: 49579-87. PMID 15358779 DOI: 10.1074/Jbc.M407340200 |
0.362 |
|
| 2004 |
Tikunova SB, Davis JP. Designing calcium-sensitizing mutations in the regulatory domain of cardiac troponin C. The Journal of Biological Chemistry. 279: 35341-52. PMID 15205455 DOI: 10.1074/Jbc.M405413200 |
0.519 |
|
| 2004 |
Davis JP, Rall JA, Alionte C, Tikunova SB. Mutations of hydrophobic residues in the N-terminal domain of troponin C affect calcium binding and exchange with the troponin C-troponin I96-148 complex and muscle force production. The Journal of Biological Chemistry. 279: 17348-60. PMID 14970231 DOI: 10.1074/Jbc.M314095200 |
0.506 |
|
| 2003 |
Luo Y, Davis JP, Tikunova SB, Smillie LB, Rall JA. Myofibrillar determinants of rate of relaxation in skinned skeletal muscle fibers. Advances in Experimental Medicine and Biology. 538: 573-81; discussion 5. PMID 15098700 DOI: 10.1007/978-1-4419-9029-7_51 |
0.442 |
|
| 2002 |
Davis JP, Rall JA, Reiser PJ, Smillie LB, Tikunova SB. Engineering competitive magnesium binding into the first EF-hand of skeletal troponin C. The Journal of Biological Chemistry. 277: 49716-26. PMID 12397067 DOI: 10.1074/Jbc.M208488200 |
0.479 |
|
| 2002 |
Tikunova SB, Rall JA, Davis JP. Effect of hydrophobic residue substitutions with glutamine on Ca(2+) binding and exchange with the N-domain of troponin C. Biochemistry. 41: 6697-705. PMID 12022873 DOI: 10.1021/Bi011763H |
0.505 |
|
| 2002 |
Johnson JD, Tikunova SB. Fluorescence methods for measuring calcium affinity and calcium exchange with proteins. Methods in Molecular Biology (Clifton, N.J.). 173: 89-102. PMID 11859781 DOI: 10.1385/1-59259-184-1:089 |
0.393 |
|
| 2002 |
Van Lierop JE, Wilson DP, Davis JP, Tikunova S, Sutherland C, Walsh MP, Johnson JD. Activation of smooth muscle myosin light chain kinase by calmodulin. Role of LYS(30) and GLY(40). The Journal of Biological Chemistry. 277: 6550-8. PMID 11748245 DOI: 10.1074/Jbc.M111404200 |
0.382 |
|
| 2001 |
Tang J, Lin Y, Zhang Z, Tikunova S, Birnbaumer L, Zhu MX. Identification of common binding sites for calmodulin and inositol 1,4,5-trisphosphate receptors on the carboxyl termini of trp channels. The Journal of Biological Chemistry. 276: 21303-10. PMID 11290752 DOI: 10.1074/Jbc.M102316200 |
0.406 |
|
| 2001 |
Zhang Z, Tang J, Tikunova S, Johnson JD, Chen Z, Qin N, Dietrich A, Stefani E, Birnbaumer L, Zhu MX. Activation of Trp3 by inositol 1,4,5-trisphosphate receptors through displacement of inhibitory calmodulin from a common binding domain. Proceedings of the National Academy of Sciences of the United States of America. 98: 3168-73. PMID 11248050 DOI: 10.1073/Pnas.051632698 |
0.477 |
|
| 2001 |
Adak S, Santolini J, Tikunova S, Wang Q, Johnson JD, Stuehr DJ. Neuronal nitric-oxide synthase mutant (Ser-1412 --> Asp) demonstrates surprising connections between heme reduction, NO complex formation, and catalysis. The Journal of Biological Chemistry. 276: 1244-52. PMID 11038355 DOI: 10.1074/Jbc.M006857200 |
0.313 |
|
| 2000 |
Black DJ, Tikunova SB, Johnson JD, Davis JP. Acid pairs increase the N-terminal Ca2+ affinity of CaM by increasing the rate of Ca2+ association Biochemistry. 39: 13831-13837. PMID 11076523 DOI: 10.1021/Bi001106+ |
0.444 |
|
| 1999 |
Kondo R, Tikunova SB, Cho MJ, Johnson JD. A point mutation in a plant calmodulin is responsible for its inhibition of nitric-oxide synthase Journal of Biological Chemistry. 274: 36213-36218. PMID 10593908 DOI: 10.1074/Jbc.274.51.36213 |
0.326 |
|
| 1999 |
Davis JP, Tikunova SB, Walsh MP, Johnson JD. Characterizing the response of calcium signal transducers to generated calcium transients Biochemistry. 38: 4235-4244. PMID 10194340 DOI: 10.1021/bi982495z |
0.422 |
|
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