Daniel Geschwind - Publications

University of California, Los Angeles, Los Angeles, CA 
Autism, Handedness, Development, Neurodegenerative Diseases, Microarrays

380 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2021 Wang JC, Ramaswami G, Geschwind DH. Gene co-expression network analysis in human spinal cord highlights mechanisms underlying amyotrophic lateral sclerosis susceptibility. Scientific Reports. 11: 5748. PMID 33707641 DOI: 10.1038/s41598-021-85061-4  0.36
2021 Gordon A, Yoon SJ, Tran SS, Makinson CD, Park JY, Andersen J, Valencia AM, Horvath S, Xiao X, Huguenard JR, Pașca SP, Geschwind DH. Long-term maturation of human cortical organoids matches key early postnatal transitions. Nature Neuroscience. PMID 33619405 DOI: 10.1038/s41593-021-00802-y  0.36
2021 Chang TS, Ding Y, Freund MK, Johnson R, Schwarz T, Yabu JM, Hazlett C, Chiang JN, Wulf DA, Geschwind DH, Butte MJ, Pasaniuc B. Pre-existing conditions in Hispanics/Latinxs that are COVID-19 risk factors. Iscience. 102188. PMID 33615196 DOI: 10.1016/j.isci.2021.102188  0.36
2021 Maor-Nof M, Shipony Z, Lopez-Gonzalez R, Nakayama L, Zhang YJ, Couthouis J, Blum JA, Castruita PA, Linares GR, Ruan K, Ramaswami G, Simon DJ, Nof A, Santana M, Han K, ... ... Geschwind DH, et al. p53 is a central regulator driving neurodegeneration caused by C9orf72 poly(PR). Cell. PMID 33482083 DOI: 10.1016/j.cell.2020.12.025  0.36
2021 Gandal MJ, Geschwind DH. Polygenicity in Psychiatry-Like It or Not, We Have to Understand It. Biological Psychiatry. 89: 2-4. PMID 33272361 DOI: 10.1016/j.biopsych.2020.10.002  0.96
2020 Page NF, Gandal MJ, Estes ML, Cameron S, Buth J, Parhami S, Ramaswami G, Murray K, Amaral DG, Van de Water JA, Schumann CM, Carter CS, Bauman MD, McAllister AK, Geschwind DH. Alterations in Retrotransposition, Synaptic Connectivity, and Myelination Implicated by Transcriptomic Changes Following Maternal Immune Activation in Nonhuman Primates. Biological Psychiatry. PMID 33386132 DOI: 10.1016/j.biopsych.2020.10.016  0.96
2020 Rexach JE, Polioudakis D, Yin A, Swarup V, Chang TS, Nguyen T, Sarkar A, Chen L, Huang J, Lin LC, Seeley W, Trojanowski JQ, Malhotra D, Geschwind DH. Tau Pathology Drives Dementia Risk-Associated Gene Networks toward Chronic Inflammatory States and Immunosuppression. Cell Reports. 33: 108398. PMID 33207193 DOI: 10.1016/j.celrep.2020.108398  0.48
2020 Jin SC, Dong W, Kundishora AJ, Panchagnula S, Moreno-De-Luca A, Furey CG, Allocco AA, Walker RL, Nelson-Williams C, Smith H, Dunbar A, Conine S, Lu Q, Zeng X, Sierant MC, ... ... Geschwind DH, et al. Exome sequencing implicates genetic disruption of prenatal neuro-gliogenesis in sporadic congenital hydrocephalus. Nature Medicine. PMID 33077954 DOI: 10.1038/s41591-020-1090-2  0.36
2020 Li Y, He X, Kawaguchi R, Zhang Y, Wang Q, Monavarfeshani A, Yang Z, Chen B, Shi Z, Meng H, Zhou S, Zhu J, Jacobi A, Swarup V, Popovich PG, ... Geschwind DH, et al. Microglia-organized scar-free spinal cord repair in neonatal mice. Nature. PMID 33029008 DOI: 10.1038/s41586-020-2795-6  0.48
2020 Ramaswami G, Won H, Gandal MJ, Haney J, Wang JC, Wong CCY, Sun W, Prabhakar S, Mill J, Geschwind DH. Integrative genomics identifies a convergent molecular subtype that links epigenomic with transcriptomic differences in autism. Nature Communications. 11: 4873. PMID 32978376 DOI: 10.1038/s41467-020-18526-1  0.96
2020 Constantino JN, Abbacchi AM, Saulnier C, Klaiman C, Mandell DS, Zhang Y, Hawks Z, Bates J, Klin A, Shattuck P, Molholm S, Fitzgerald R, Roux A, Lowe JK, Geschwind DH. Timing of the Diagnosis of Autism in African American Children. Pediatrics. PMID 32839243 DOI: 10.1542/peds.2019-3629  0.44
2020 Adhya D, Swarup V, Nagy R, Dutan L, Shum C, Valencia-Alarcón EP, Jozwik KM, Mendez MA, Horder J, Loth E, Nowosiad P, Lee I, Skuse D, Flinter FA, Murphy D, ... ... Geschwind DH, et al. Atypical Neurogenesis in Induced Pluripotent Stem Cells From Autistic Individuals. Biological Psychiatry. PMID 32826066 DOI: 10.1016/j.biopsych.2020.06.014  0.48
2020 Chang TS, Ding Y, Freund MK, Johnson R, Schwarz T, Yabu JM, Hazlett C, Chiang JN, Wulf A, Geschwind DH, Butte MJ, Pasaniuc B. Prior diagnoses and medications as risk factors for COVID-19 in a Los Angeles Health System. Medrxiv : the Preprint Server For Health Sciences. PMID 32637977 DOI: 10.1101/2020.07.03.20145581  0.36
2020 Swarup V, Chang TS, Duong DM, Dammer EB, Dai J, Lah JJ, Johnson ECB, Seyfried NT, Levey AI, Geschwind DH. Identification of Conserved Proteomic Networks in Neurodegenerative Dementia. Cell Reports. 31: 107807. PMID 32579933 DOI: 10.1016/j.celrep.2020.107807  0.48
2020 Walker RL, Ramaswami G, Hartl C, Mancuso N, Gandal MJ, de la Torre-Ubieta L, Pasaniuc B, Stein JL, Geschwind DH. Genetic Control of Expression and Splicing in Developing Human Brain Informs Disease Mechanisms. Cell. 181: 745. PMID 32359439 DOI: 10.1016/j.cell.2020.04.016  0.96
2020 Walker RL, Ramaswami G, Hartl C, Mancuso N, Gandal MJ, Torre-Ubieta L, Pasaniuc B, Stein JL, Geschwind DH. Genetic Control of Expression and Splicing in Developing Human Brain Informs Disease Mechanisms. Cell. 181: 484. PMID 32302575 DOI: 10.1016/j.cell.2020.04.003  0.96
2020 Hernandez LM, Lawrence KE, Padgaonkar NT, Inada M, Hoekstra JN, Lowe JK, Eilbott J, Jack A, Aylward E, Gaab N, Van Horn JD, Bernier RA, McPartland JC, Webb SJ, Pelphrey KA, ... ... Geschwind DH, et al. Imaging-genetics of sex differences in ASD: distinct effects of OXTR variants on brain connectivity. Translational Psychiatry. 10: 82. PMID 32127526 DOI: 10.1038/s41398-020-0750-9  0.44
2019 Gandal MJ, Haney JR, Parikshak NN, Leppa V, Ramaswami G, Hartl C, Schork AJ, Appadurai V, Buil A, Werge TM, Liu C, White KP, Geschwind DH. Shared Molecular Neuropathology Across Major Psychiatric Disorders Parallels Polygenic Overlap. Focus (American Psychiatric Publishing). 17: 66-72. PMID 32015716 DOI: 10.1176/appi.focus.17103  0.96
2019 Ngo KJ, Rexach JE, Lee H, Petty LE, Perlman S, Valera JM, Deignan JL, Mao Y, Aker M, Posey JE, Jhangiani SN, Coban-Akdemir ZH, Boerwinkle E, Muzny D, Nelson AB, ... ... Geschwind DH, et al. A Diagnostic Ceiling for Exome Sequencing in Cerebellar Ataxia and Related Neurological Disorders. Human Mutation. PMID 31692161 DOI: 10.1002/humu.23946  0.36
2019 Walker RL, Ramaswami G, Hartl C, Mancuso N, Gandal MJ, de la Torre-Ubieta L, Pasaniuc B, Stein JL, Geschwind DH. Genetic Control of Expression and Splicing in Developing Human Brain Informs Disease Mechanisms. Cell. 179: 750-771.e22. PMID 31626773 DOI: 10.1016/j.cell.2019.09.021  0.96
2019 Forsyth JK, Nachun D, Gandal MJ, Geschwind DH, Anderson AE, Coppola G, Bearden CE. Synaptic and Gene Regulatory Mechanisms in Schizophrenia, Autism, and 22q11.2 Copy Number Variant-Mediated Risk for Neuropsychiatric Disorders. Biological Psychiatry. PMID 31500805 DOI: 10.1016/j.biopsych.2019.06.029  0.96
2019 Shi G, Xing L, Wu D, Bhattacharyya BJ, Jones CR, McMahon T, Chong SYC, Chen JA, Coppola G, Geschwind D, Krystal A, Ptáček LJ, Fu YH. A Rare Mutation of β-Adrenergic Receptor Affects Sleep/Wake Behaviors. Neuron. PMID 31473062 DOI: 10.1016/j.neuron.2019.07.026  0.48
2019 Lee C, Kang EY, Gandal MJ, Eskin E, Geschwind DH. Profiling allele-specific gene expression in brains from individuals with autism spectrum disorder reveals preferential minor allele usage. Nature Neuroscience. 22: 1521-1532. PMID 31455884 DOI: 10.1038/s41593-019-0461-9  0.96
2019 Ruzzo EK, Pérez-Cano L, Jung JY, Wang LK, Kashef-Haghighi D, Hartl C, Singh C, Xu J, Hoekstra JN, Leventhal O, Leppä VM, Gandal MJ, Paskov K, Stockham N, Polioudakis D, ... ... Geschwind DH, et al. Inherited and De Novo Genetic Risk for Autism Impacts Shared Networks. Cell. 178: 850-866.e26. PMID 31398340 DOI: 10.1016/j.cell.2019.07.015  0.96
2019 Polioudakis D, de la Torre-Ubieta L, Langerman J, Elkins AG, Shi X, Stein JL, Vuong CK, Nichterwitz S, Gevorgian M, Opland CK, Lu D, Connell W, Ruzzo EK, Lowe JK, Hadzic T, ... ... Geschwind DH, et al. A Single-Cell Transcriptomic Atlas of Human Neocortical Development during Mid-gestation. Neuron. PMID 31303374 DOI: 10.1016/j.neuron.2019.06.011  0.44
2019 Wong CCY, Smith RG, Hannon E, Ramaswami G, Parikshak NN, Assary E, Troakes C, Poschmann J, Schalkwyk LC, Sun W, Prabhakar S, Geschwind DH, Mill J. Genome-wide DNA methylation profiling identifies convergent molecular signatures associated with idiopathic and syndromic autism in post-mortem human brain tissue. Human Molecular Genetics. 28: 2201-2211. PMID 31220268 DOI: 10.1093/hmg/ddz052  0.96
2019 Pardiñas AF, Holmans P, Pocklington AJ, Escott-Price V, Ripke S, Carrera N, Legge SE, Bishop S, Cameron D, Hamshere ML, Han J, Hubbard L, Lynham A, Mantripragada K, Rees E, ... ... Geschwind DH, et al. Publisher Correction: Common schizophrenia alleles are enriched in mutation-intolerant genes and in regions under strong background selection. Nature Genetics. PMID 31160808 DOI: 10.1038/s41588-019-0450-7  0.6
2019 Won H, Huang J, Opland CK, Hartl CL, Geschwind DH. Human evolved regulatory elements modulate genes involved in cortical expansion and neurodevelopmental disease susceptibility. Nature Communications. 10: 2396. PMID 31160561 DOI: 10.1038/s41467-019-10248-3  0.6
2019 Sharon G, Cruz NJ, Kang DW, Gandal MJ, Wang B, Kim YM, Zink EM, Casey CP, Taylor BC, Lane CJ, Bramer LM, Isern NG, Hoyt DW, Noecker C, Sweredoski MJ, ... ... Geschwind DH, et al. Human Gut Microbiota from Autism Spectrum Disorder Promote Behavioral Symptoms in Mice. Cell. 177: 1600-1618.e17. PMID 31150625 DOI: 10.1016/j.cell.2019.05.004  0.96
2019 Lazaro MT, Taxidis J, Shuman T, Bachmutsky I, Ikrar T, Santos R, Marcello GM, Mylavarapu A, Chandra S, Foreman A, Goli R, Tran D, Sharma N, Azhdam M, Dong H, ... ... Geschwind DH, et al. Reduced Prefrontal Synaptic Connectivity and Disturbed Oscillatory Population Dynamics in the CNTNAP2 Model of Autism. Cell Reports. 27: 2567-2578.e6. PMID 31141683 DOI: 10.1016/j.celrep.2019.05.006  0.48
2019 Chen Z, Chen JA, Shatunov A, Jones AR, Kravitz SN, Huang AY, Lawrence L, Lowe JK, Lewis CM, Payan CAM, Lieb W, Franke A, Deloukas P, Amouyel P, Tzourio C, ... ... Geschwind DH, et al. Genome-wide survey of copy number variants finds MAPT duplications in progressive supranuclear palsy. Movement Disorders : Official Journal of the Movement Disorder Society. PMID 31059154 DOI: 10.1002/mds.27702  0.48
2019 Alim I, Caulfield JT, Chen Y, Swarup V, Geschwind DH, Ivanova E, Seravalli J, Ai Y, Sansing LH, Ste Marie EJ, Hondal RJ, Mukherjee S, Cave JW, Sagdullaev BT, Karuppagounder SS, et al. Selenium Drives a Transcriptional Adaptive Program to Block Ferroptosis and Treat Stroke. Cell. PMID 31056284 DOI: 10.1016/j.cell.2019.03.032  0.48
2019 Prohaska A, Racimo F, Schork AJ, Sikora M, Stern AJ, Ilardo M, Allentoft ME, Folkersen L, Buil A, Moreno-Mayar JV, Korneliussen T, Geschwind D, Ingason A, Werge T, Nielsen R, et al. Human Disease Variation in the Light of Population Genomics. Cell. 177: 115-131. PMID 30901534 DOI: 10.1016/j.cell.2019.01.052  0.32
2019 Grove J, Ripke S, Als TD, Mattheisen M, Walters RK, Won H, Pallesen J, Agerbo E, Andreassen OA, Anney R, Awashti S, Belliveau R, Bettella F, Buxbaum JD, Bybjerg-Grauholm J, ... ... Geschwind DH, et al. Identification of common genetic risk variants for autism spectrum disorder. Nature Genetics. PMID 30804558 DOI: 10.1038/s41588-019-0344-8  0.6
2019 Schork AJ, Won H, Appadurai V, Nudel R, Gandal M, Delaneau O, Revsbech Christiansen M, Hougaard DM, Bækved-Hansen M, Bybjerg-Grauholm J, Giørtz Pedersen M, Agerbo E, Bøcker Pedersen C, Neale BM, Daly MJ, ... ... Geschwind DH, et al. A genome-wide association study of shared risk across psychiatric disorders implicates gene regulation during fetal neurodevelopment. Nature Neuroscience. PMID 30692689 DOI: 10.1038/s41593-018-0320-0  0.6
2019 Tran SS, Jun HI, Bahn JH, Azghadi A, Ramaswami G, Van Nostrand EL, Nguyen TB, Hsiao YE, Lee C, Pratt GA, Martínez-Cerdeño V, Hagerman RJ, Yeo GW, Geschwind DH, Xiao X. Widespread RNA editing dysregulation in brains from autistic individuals. Nature Neuroscience. 22: 25-36. PMID 30559470 DOI: 10.1038/s41593-018-0287-x  0.36
2018 Fan CC, McGrath JJ, Appadurai V, Buil A, Gandal MJ, Schork AJ, Mortensen PB, Agerbo E, Geschwind SA, Geschwind D, Werge T, Thompson WK, Pedersen CB. Spatial fine-mapping for gene-by-environment effects identifies risk hot spots for schizophrenia. Nature Communications. 9: 5296. PMID 30546018 DOI: 10.1038/s41467-018-07708-7  0.96
2018 Wang D, Liu S, Warrell J, Won H, Shi X, Navarro FCP, Clarke D, Gu M, Emani P, Yang YT, Xu M, Gandal MJ, Lou S, Zhang J, Park JJ, ... ... Geschwind DH, et al. Comprehensive functional genomic resource and integrative model for the human brain. Science (New York, N.Y.). 362. PMID 30545857 DOI: 10.1126/science.aat8464  0.96
2018 Gandal MJ, Zhang P, Hadjimichael E, Walker RL, Chen C, Liu S, Won H, van Bakel H, Varghese M, Wang Y, Shieh AW, Haney J, Parhami S, Belmont J, Kim M, ... ... Geschwind DH, et al. Transcriptome-wide isoform-level dysregulation in ASD, schizophrenia, and bipolar disorder. Science (New York, N.Y.). 362. PMID 30545856 DOI: 10.1126/science.aat8127  0.96
2018 Li M, Santpere G, Imamura Kawasawa Y, Evgrafov OV, Gulden FO, Pochareddy S, Sunkin SM, Li Z, Shin Y, Zhu Y, Sousa AMM, Werling DM, Kitchen RR, Kang HJ, Pletikos M, ... ... Geschwind DH, et al. Integrative functional genomic analysis of human brain development and neuropsychiatric risks. Science (New York, N.Y.). 362. PMID 30545854 DOI: 10.1126/science.aat7615  0.96
2018 Rajarajan P, Borrman T, Liao W, Schrode N, Flaherty E, Casiño C, Powell S, Yashaswini C, LaMarca EA, Kassim B, Javidfar B, Espeso-Gil S, Li A, Won H, Geschwind DH, et al. Neuron-specific signatures in the chromosomal connectome associated with schizophrenia risk. Science (New York, N.Y.). 362. PMID 30545851 DOI: 10.1126/science.aat4311  0.6
2018 Swarup V, Hinz FI, Rexach JE, Noguchi KI, Toyoshiba H, Oda A, Hirai K, Sarkar A, Seyfried NT, Cheng C, Haggarty SJ, Grossman M, Van Deerlin VM, Trojanowski JQ, ... ... Geschwind DH, et al. Identification of evolutionarily conserved gene networks mediating neurodegenerative dementia. Nature Medicine. PMID 30510257 DOI: 10.1038/s41591-018-0223-3  0.48
2018 Demontis D, Walters RK, Martin J, Mattheisen M, Als TD, Agerbo E, Baldursson G, Belliveau R, Bybjerg-Grauholm J, Bækvad-Hansen M, Cerrato F, Chambert K, Churchhouse C, Dumont A, Eriksson N, ... ... Geschwind D, et al. Discovery of the first genome-wide significant risk loci for attention deficit/hyperactivity disorder. Nature Genetics. PMID 30478444 DOI: 10.1038/s41588-018-0269-7  0.6
2018 Kimura R, Swarup V, Tomiwa K, Gandal MJ, Parikshak NN, Funabiki Y, Nakata M, Awaya T, Kato T, Iida K, Okazaki S, Matsushima K, Kato T, Murai T, Heike T, ... Geschwind DH, et al. Integrative network analysis reveals biological pathways associated with Williams syndrome. Journal of Child Psychology and Psychiatry, and Allied Disciplines. PMID 30362171 DOI: 10.1111/jcpp.12999  0.96
2018 Parras A, Anta H, Santos-Galindo M, Swarup V, Elorza A, Nieto-González JL, Picó S, Hernández IH, Díaz-Hernández JI, Belloc E, Rodolosse A, Parikshak NN, Peñagarikano O, Fernández-Chacón R, Irimia M, ... ... Geschwind DH, et al. Autism-like phenotype and risk gene mRNA deadenylation by CPEB4 mis-splicing. Nature. PMID 30111840 DOI: 10.1038/s41586-018-0423-5  0.96
2018 Chen JA, Chen Z, Won H, Huang AY, Lowe JK, Wojta K, Yokoyama JS, Bensimon G, Leigh PN, Payan C, Shatunov A, Jones AR, Lewis CM, Deloukas P, Amouyel P, ... ... Geschwind DH, et al. Joint genome-wide association study of progressive supranuclear palsy identifies novel susceptibility loci and genetic correlation to neurodegenerative diseases. Molecular Neurodegeneration. 13: 41. PMID 30089514 DOI: 10.1186/s13024-018-0270-8  0.6
2018 Parikshak NN, Swarup V, Belgard TG, Irimia M, Ramaswami G, Gandal MJ, Hartl C, Leppa V, de la Torre Ubieta L, Huang J, Lowe JK, Blencowe BJ, Horvath S, Geschwind DH. Author Correction: Genome-wide changes in lncRNA, splicing, and regional gene expression patterns in autism. Nature. PMID 29995847 DOI: 10.1038/s41586-018-0295-8  0.96
2018 Ramos EM, Carecchio M, Lemos R, Ferreira J, Legati A, Sears RL, Hsu SC, Panteghini C, Magistrelli L, Salsano E, Esposito S, Taroni F, Richard AC, Tranchant C, Anheim M, ... ... Geschwind DH, et al. Primary brain calcification: an international study reporting novel variants and associated phenotypes. European Journal of Human Genetics : Ejhg. PMID 29955172 DOI: 10.1038/s41431-018-0185-4  0.36
2018 Raznahan A, Parikshak NN, Chandran V, Blumenthal JD, Clasen LS, Alexander-Bloch AF, Zinn AR, Wangsa D, Wise J, Murphy DGM, Bolton PF, Ried T, Ross J, Giedd JN, Geschwind DH. Sex-chromosome dosage effects on gene expression in humans. Proceedings of the National Academy of Sciences of the United States of America. PMID 29946024 DOI: 10.1073/pnas.1802889115  0.96
2018 Anttila V, Bulik-Sullivan B, Finucane HK, Walters RK, Bras J, Duncan L, Escott-Price V, Falcone GJ, Gormley P, Malik R, Patsopoulos NA, Ripke S, Wei Z, Yu D, ... ... Geschwind DH, et al. Analysis of shared heritability in common disorders of the brain. Science (New York, N.Y.). 360. PMID 29930110 DOI: 10.1126/science.aap8757  0.44
2018 Schwede M, Nagpal S, Gandal MJ, Parikshak NN, Mirnics K, Geschwind DH, Morrow EM. Strong correlation of downregulated genes related to synaptic transmission and mitochondria in post-mortem autism cerebral cortex. Journal of Neurodevelopmental Disorders. 10: 18. PMID 29859039 DOI: 10.1186/s11689-018-9237-x  0.96
2018 Gusev A, Mancuso N, Won H, Kousi M, Finucane HK, Reshef Y, Song L, Safi A, McCarroll S, Neale BM, Ophoff RA, O'Donovan MC, Crawford GE, Geschwind DH, et al. Transcriptome-wide association study of schizophrenia and chromatin activity yields mechanistic disease insights. Nature Genetics. 50: 538-548. PMID 29632383 DOI: 10.1038/s41588-018-0092-1  0.6
2018 Short PJ, McRae JF, Gallone G, Sifrim A, Won H, Geschwind DH, Wright CF, Firth HV, FitzPatrick DR, Barrett JC, Hurles ME. De novo mutations in regulatory elements in neurodevelopmental disorders. Nature. PMID 29562236 DOI: 10.1038/nature25983  0.6
2018 Sanders SJ, Neale BM, Huang H, Werling DM, An JY, Dong S, Abecasis G, Arguello PA, Blangero J, Boehnke M, Daly MJ, Eggan K, Geschwind DH, Glahn DC, Goldstein DB, et al. Publisher Correction: Whole genome sequencing in psychiatric disorders: the WGSPD consortium. Nature Neuroscience. PMID 29549319 DOI: 10.1038/s41593-018-0102-8  0.96
2018 Pardiñas AF, Holmans P, Pocklington AJ, Escott-Price V, Ripke S, Carrera N, Legge SE, Bishop S, Cameron D, Hamshere ML, Han J, Hubbard L, Lynham A, Mantripragada K, Rees E, ... ... Geschwind DH, et al. Common schizophrenia alleles are enriched in mutation-intolerant genes and in regions under strong background selection. Nature Genetics. PMID 29483656 DOI: 10.1038/s41588-018-0059-2  0.6
2018 Gandal MJ, Haney JR, Parikshak NN, Leppa V, Ramaswami G, Hartl C, Schork AJ, Appadurai V, Buil A, Werge TM, Liu C, White KP, ... ... Geschwind DH, et al. Shared molecular neuropathology across major psychiatric disorders parallels polygenic overlap. Science (New York, N.Y.). 359: 693-697. PMID 29439242 DOI: 10.1126/science.aad6469  0.96
2018 Cobos EJ, Nickerson CA, Gao F, Chandran V, Bravo-Caparrós I, González-Cano R, Riva P, Andrews NA, Latremoliere A, Seehus CR, Perazzoli G, Nieto FR, Joller N, Painter MW, Ma CHE, ... ... Geschwind DH, et al. Mechanistic Differences in Neuropathic Pain Modalities Revealed by Correlating Behavior with Global Expression Profiling. Cell Reports. 22: 1301-1312. PMID 29386116 DOI: 10.1016/j.celrep.2018.01.006  0.36
2018 Ramaswami G, Geschwind DH. Genetics of autism spectrum disorder. Handbook of Clinical Neurology. 147: 321-329. PMID 29325621 DOI: 10.1016/B978-0-444-63233-3.00021-X  0.36
2018 de la Torre-Ubieta L, Stein JL, Won H, Opland CK, Liang D, Lu D, Geschwind DH. The Dynamic Landscape of Open Chromatin during Human Cortical Neurogenesis. Cell. PMID 29307494 DOI: 10.1016/j.cell.2017.12.014  0.6
2017 Chandran V, Gao K, Swarup V, Versano R, Dong H, Jordan MC, Geschwind DH. Inducible and reversible phenotypes in a novel mouse model of Friedreich's Ataxia. Elife. 6. PMID 29257745 DOI: 10.7554/eLife.30054  0.48
2017 Sanders SJ, Neale BM, Huang H, Werling DM, An JY, Dong S, Abecasis G, Arguello PA, Blangero J, Boehnke M, Daly MJ, Eggan K, Geschwind DH, Glahn DC, Goldstein DB, et al. Whole genome sequencing in psychiatric disorders: the WGSPD consortium. Nature Neuroscience. 20: 1661-1668. PMID 29184211 DOI: 10.1038/s41593-017-0017-9  0.96
2017 Tu S, Akhtar MW, Escorihuela RM, Amador-Arjona A, Swarup V, Parker J, Zaremba JD, Holland T, Bansal N, Holohan DR, Lopez K, Ryan SD, Chan SF, Yan L, Zhang X, ... ... Geschwind DH, et al. NitroSynapsin therapy for a mouse MEF2C haploinsufficiency model of human autism. Nature Communications. 8: 1488. PMID 29133852 DOI: 10.1038/s41467-017-01563-8  0.48
2017 Allen M, Wang X, Burgess JD, Watzlawik J, Serie DJ, Younkin CS, Nguyen T, Malphrus KG, Lincoln S, Carrasquillo MM, Ho C, Chakrabarty P, Strickland S, Murray ME, Swarup V, ... Geschwind DH, et al. Conserved brain myelination networks are altered in Alzheimer's and other neurodegenerative diseases. Alzheimer's & Dementia : the Journal of the Alzheimer's Association. PMID 29107053 DOI: 10.1016/j.jalz.2017.09.012  0.48
2017 Valera JM, Diaz T, Petty LE, Quintáns B, Yáñez Z, Boerwinkle E, Muzny D, Akhmedov D, Berdeaux R, Sobrido MJ, Gibbs R, Lupski JR, Geschwind DH, Perlman S, Below JE, et al. Prevalence of spinocerebellar ataxia 36 in a US population. Neurology. Genetics. 3: e174. PMID 28761930 DOI: 10.1212/NXG.0000000000000174  0.36
2017 Lu AT, Hannon E, Levine ME, Crimmins EM, Lunnon K, Mill J, Geschwind DH, Horvath S. Genetic architecture of epigenetic and neuronal ageing rates in human brain regions. Nature Communications. 8: 15353. PMID 28516910 DOI: 10.1038/ncomms15353  0.36
2017 Lopez A, Lee SE, Wojta K, Ramos EM, Klein E, Chen J, Boxer AL, Gorno-Tempini ML, Geschwind DH, Schlotawa L, Ogryzko NV, Bigio EH, Rogalski E, Weintraub S, Mesulam MM, et al. A152T tau allele causes neurodegeneration that can be ameliorated in a zebrafish model by autophagy induction. Brain : a Journal of Neurology. PMID 28334843 DOI: 10.1093/brain/awx005  0.44
2016 Seyfried NT, Dammer EB, Swarup V, Nandakumar D, Duong DM, Yin L, Deng Q, Nguyen T, Hales CM, Wingo T, Glass J, Gearing M, Thambisetty M, Troncoso JC, Geschwind DH, et al. A Multi-network Approach Identifies Protein-Specific Co-expression in Asymptomatic and Symptomatic Alzheimer's Disease. Cell Systems. PMID 27989508 DOI: 10.1016/j.cels.2016.11.006  0.48
2016 Parikshak NN, Swarup V, Belgard TG, Irimia M, Ramaswami G, Gandal MJ, Hartl C, Leppa V, Ubieta LT, Huang J, Lowe JK, Blencowe BJ, Horvath S, Geschwind DH. Genome-wide changes in lncRNA, splicing, and regional gene expression patterns in autism. Nature. PMID 27919067 DOI: 10.1038/nature20612  0.96
2016 Sun W, Poschmann J, Cruz-Herrera Del Rosario R, Parikshak NN, Hajan HS, Kumar V, Ramasamy R, Belgard TG, Elanggovan B, Wong CC, Mill J, Geschwind DH, Prabhakar S. Histone Acetylome-wide Association Study of Autism Spectrum Disorder. Cell. 167: 1385-1397.e11. PMID 27863250 DOI: 10.1016/j.cell.2016.10.031  0.96
2016 Gandal MJ, Leppa V, Won H, Parikshak NN, Geschwind DH. The road to precision psychiatry: translating genetics into disease mechanisms. Nature Neuroscience. 19: 1397-1407. PMID 27786179 DOI: 10.1038/nn.4409  0.96
2016 Won H, de la Torre-Ubieta L, Stein JL, Parikshak NN, Huang J, Opland CK, Gandal MJ, Sutton GJ, Hormozdiari F, Lu D, Lee C, Eskin E, Voineagu I, Ernst J, Geschwind DH. Chromosome conformation elucidates regulatory relationships in developing human brain. Nature. PMID 27760116 DOI: 10.1038/nature19847  0.96
2016 Silva MC, Cheng C, Mair W, Almeida S, Fong H, Biswas MH, Zhang Z, Huang Y, Temple S, Coppola G, Geschwind DH, Karydas A, Miller BL, Kosik KS, Gao FB, et al. Human iPSC-Derived Neuronal Model of Tau-A152T Frontotemporal Dementia Reveals Tau-Mediated Mechanisms of Neuronal Vulnerability. Stem Cell Reports. PMID 27594585 DOI: 10.1016/j.stemcr.2016.08.001  1
2016 Wu YE, Parikshak NN, Belgard TG, Geschwind DH. Genome-wide, integrative analysis implicates microRNA dysregulation in autism spectrum disorder. Nature Neuroscience. PMID 27571009 DOI: 10.1038/nn.4373  0.96
2016 Leppa VM, Kravitz SN, Martin CL, Andrieux J, Le Caignec C, Martin-Coignard D, DyBuncio C, Sanders SJ, Lowe JK, Cantor RM, Geschwind DH. Rare Inherited and De Novo CNVs Reveal Complex Contributions to ASD Risk in Multiplex Families. American Journal of Human Genetics. PMID 27569545 DOI: 10.1016/j.ajhg.2016.06.036  0.44
2016 Bagot RC, Cates HM, Purushothaman I, Lorsch ZS, Walker DM, Wang J, Huang X, Schlüter OM, Maze I, Peña CJ, Heller EA, Issler O, Wang M, Song WM, Stein JL, ... ... Geschwind D, et al. Circuit-wide Transcriptional Profiling Reveals Brain Region-Specific Gene Networks Regulating Depression Susceptibility. Neuron. PMID 27181059 DOI: 10.1016/j.neuron.2016.04.015  1
2016 Omura T, Omura K, Tedeschi A, Riva P, Painter MW, Rojas L, Martin J, Lisi V, Huebner EA, Latremoliere A, Yin Y, Barrett LB, Singh B, Lee S, Crisman T, ... ... Geschwind DH, et al. Robust Axonal Regeneration Occurs in the Injured CAST/Ei Mouse CNS. Neuron. 90: 662. PMID 27151643 DOI: 10.1016/j.neuron.2016.04.025  0.36
2016 de la Torre-Ubieta L, Won H, Stein JL, Geschwind DH. Advancing the understanding of autism disease mechanisms through genetics. Nature Medicine. 22: 345-361. PMID 27050589 DOI: 10.1038/nm.4071  1
2016 Gandal MJ, Geschwind DH. The Genetics-Driven Revival in Neuropsychiatric Drug Development. Biological Psychiatry. 79: 628-30. PMID 26997117 DOI: 10.1016/j.biopsych.2016.02.024  0.96
2016 Singh T, Kurki MI, Curtis D, Purcell SM, Crooks L, McRae J, Suvisaari J, Chheda H, Blackwood D, Breen G, Pietiläinen O, Gerety SS, Ayub M, Blyth M, Cole T, ... ... Geschwind D, et al. Rare loss-of-function variants in SETD1A are associated with schizophrenia and developmental disorders. Nature Neuroscience. PMID 26974950 DOI: 10.1038/nn.4267  1
2016 Chandran V, Coppola G, Nawabi H, Omura T, Versano R, Huebner EA, Zhang A, Costigan M, Yekkirala A, Barrett L, Blesch A, Michaelevski I, Davis-Turak J, Gao F, Langfelder P, ... ... Geschwind DH, et al. A Systems-Level Analysis of the Peripheral Nerve Intrinsic Axonal Growth Program. Neuron. PMID 26898779 DOI: 10.1016/j.neuron.2016.01.034  1
2016 Werling DM, Parikshak NN, Geschwind DH. Gene expression in human brain implicates sexually dimorphic pathways in autism spectrum disorders. Nature Communications. 7: 10717. PMID 26892004 DOI: 10.1038/ncomms10717  0.96
2016 Jeste SS, Geschwind DH. Clinical trials for neurodevelopmental disorders: At a therapeutic frontier. Science Translational Medicine. 8: 321fs1. PMID 26764154 DOI: 10.1126/scitranslmed.aad9874  1
2015 Lee JA, Damianov A, Lin CH, Fontes M, Parikshak NN, Anderson ES, Geschwind DH, Black DL, Martin KC. Cytoplasmic Rbfox1 Regulates the Expression of Synaptic and Autism-Related Genes. Neuron. PMID 26687839 DOI: 10.1016/j.neuron.2015.11.025  0.96
2015 Berg JM, Lee C, Chen L, Galvan L, Cepeda C, Chen JY, Peñagarikano O, Stein JL, Li A, Oguro-Ando A, Miller JA, Vashisht AA, Starks ME, Kite EP, Tam E, ... ... Geschwind DH, et al. JAKMIP1, a Novel Regulator of Neuronal Translation, Modulates Synaptic Function and Autistic-like Behaviors in Mouse. Neuron. PMID 26627310 DOI: 10.1016/j.neuron.2015.10.031  1
2015 Akbarian S, Liu C, Knowles JA, Vaccarino FM, Farnham PJ, Crawford GE, Jaffe AE, Pinto D, Dracheva S, Geschwind DH, Mill J, Nairn AC, Abyzov A, Pochareddy S, Prabhakar S, et al. The PsychENCODE project. Nature Neuroscience. 18: 1707-1712. PMID 26605881 DOI: 10.1038/nn.4156  1
2015 Wang GZ, Belgard TG, Mao D, Chen L, Berto S, Preuss TM, Lu H, Geschwind DH, Konopka G. Correspondence between Resting-State Activity and Brain Gene Expression. Neuron. 88: 659-666. PMID 26590343 DOI: 10.1016/j.neuron.2015.10.022  1
2015 Geschwind DH, Flint J. Genetics and genomics of psychiatric disease. Science (New York, N.Y.). 349: 1489-94. PMID 26404826 DOI: 10.1126/science.aaa8954  1
2015 Sanders SJ, He X, Willsey AJ, Ercan-Sencicek AG, Samocha KE, Cicek AE, Murtha MT, Bal VH, Bishop SL, Dong S, Goldberg AP, Jinlu C, Keaney JF, Klei L, Mandell JD, ... ... Geschwind DH, et al. Insights into Autism Spectrum Disorder Genomic Architecture and Biology from 71 Risk Loci. Neuron. 87: 1215-1233. PMID 26402605 DOI: 10.1016/j.neuron.2015.09.016  1
2015 Chiam JT, Lunnon K, Voyle N, Proitsi P, Coppola G, Geschwind D, Nelson S, Johnston C, Soininen H, Kłoszewska I, Mecocci P, Tsolaki M, Vellas B, Hodges A, Lovestone S, et al. No Evidence to Suggest that the Use of Acetylcholinesterase Inhibitors Confounds the Results of Two Blood-Based Biomarker Studies in Alzheimer's Disease. Journal of Alzheimer's Disease : Jad. 47: 741-50. PMID 26401708 DOI: 10.3233/JAD-150289  1
2015 Prusiner SB, Woerman AL, Mordes DA, Watts JC, Rampersaud R, Berry DB, Patel S, Oehler A, Lowe JK, Kravitz SN, Geschwind DH, Glidden DV, Halliday GM, Middleton LT, Gentleman SM, et al. Evidence for α-synuclein prions causing multiple system atrophy in humans with parkinsonism. Proceedings of the National Academy of Sciences of the United States of America. 112: E5308-17. PMID 26324905 DOI: 10.1073/pnas.1514475112  0.44
2015 Sha SJ, Khazenzon AM, Ghosh PM, Rankin KP, Pribadi M, Coppola G, Geschwind DH, Rabinovici GD, Miller BL, Lee SE. Early-onset Alzheimer's disease versus frontotemporal dementia: resolution with genetic diagnoses? Neurocase. 1-7. PMID 26304661 DOI: 10.1080/13554794.2015.1080283  1
2015 Jalbrzikowski M, Lazaro MT, Gao F, Huang A, Chow C, Geschwind DH, Coppola G, Bearden CE. Transcriptome Profiling of Peripheral Blood in 22q11.2 Deletion Syndrome Reveals Functional Pathways Related to Psychosis and Autism Spectrum Disorder. Plos One. 10: e0132542. PMID 26201030 DOI: 10.1371/journal.pone.0132542  0.36
2015 Kloth AD, Badura A, Li A, Cherskov A, Connolly SG, Giovannucci A, Bangash MA, Grasselli G, Peñagarikano O, Piochon C, Tsai PT, Geschwind DH, Hansel C, Sahin M, Takumi T, et al. Cerebellar associative sensory learning defects in five mouse autism models. Elife. 4. PMID 26158416 DOI: 10.7554/eLife.06085  1
2015 Parikshak NN, Gandal MJ, Geschwind DH. Systems biology and gene networks in neurodevelopmental and neurodegenerative disorders. Nature Reviews. Genetics. 16: 441-58. PMID 26149713 DOI: 10.1038/nrg3934  1
2015 Nicolas G, Charbonnier C, de Lemos RR, Richard AC, Guillin O, Wallon D, Legati A, Geschwind D, Coppola G, Frebourg T, Campion D, de Oliveira JR, Hannequin D. Brain calcification process and phenotypes according to age and sex: Lessons from SLC20A2, PDGFB, and PDGFRB mutation carriers. American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics. PMID 26129893 DOI: 10.1002/ajmg.b.32336  1
2015 Mesquita SD, Ferreira AC, Gao F, Coppola G, Geschwind DH, Sousa JC, Correia-Neves M, Sousa N, Palha JA, Marques F. The choroid plexus transcriptome reveals changes in type I and II interferon responses in a mouse model of Alzheimer's disease. Brain, Behavior, and Immunity. 49: 280-92. PMID 26092102 DOI: 10.1016/j.bbi.2015.06.008  1
2015 Mukherjee S, Walter S, Kauwe JS, Saykin AJ, Bennett DA, Larson EB, Crane PK, Glymour MM. Genetically predicted body mass index and Alzheimer's disease-related phenotypes in three large samples: Mendelian randomization analyses. Alzheimer's & Dementia : the Journal of the Alzheimer's Association. PMID 26079416 DOI: 10.1016/j.jalz.2015.05.015  1
2015 Burkett ZD, Day NF, Peñagarikano O, Geschwind DH, White SA. VoICE: A semi-automated pipeline for standardizing vocal analysis across models. Scientific Reports. 5: 10237. PMID 26018425 DOI: 10.1038/srep10237  1
2015 Omura T, Omura K, Tedeschi A, Riva P, Painter MW, Rojas L, Martin J, Lisi V, Huebner EA, Latremoliere A, Yin Y, Barrett LB, Singh B, Lee S, Crisman T, ... ... Geschwind DH, et al. Robust Axonal Regeneration Occurs in the Injured CAST/Ei Mouse CNS. Neuron. 86: 1215-27. PMID 26004914 DOI: 10.1016/j.neuron.2015.05.005  1
2015 Werling DM, Geschwind DH. Recurrence rates provide evidence for sex-differential, familial genetic liability for autism spectrum disorders in multiplex families and twins. Molecular Autism. 6: 27. PMID 25973164 DOI: 10.1186/s13229-015-0004-5  0.96
2015 Bakken TE, Miller JA, Luo R, Bernard A, Bennett JL, Lee CK, Bertagnolli D, Parikshak NN, Smith KA, Sunkin SM, Amaral DG, Geschwind DH, Lein ES. Spatiotemporal dynamics of the postnatal developing primate brain transcriptome. Human Molecular Genetics. 24: 4327-39. PMID 25954031 DOI: 10.1093/hmg/ddv166  0.96
2015 Legati A, Giovannini D, Nicolas G, López-Sánchez U, Quintáns B, Oliveira JR, Sears RL, Ramos EM, Spiteri E, Sobrido MJ, Carracedo Á, Castro-Fernández C, Cubizolle S, Fogel BL, Goizet C, ... ... Geschwind DH, et al. Mutations in XPR1 cause primary familial brain calcification associated with altered phosphate export. Nature Genetics. 47: 579-81. PMID 25938945 DOI: 10.1038/ng.3289  1
2015 Yu H, Su Y, Shin J, Zhong C, Guo JU, Weng YL, Gao F, Geschwind DH, Coppola G, Ming GL, Song H. Tet3 regulates synaptic transmission and homeostatic plasticity via DNA oxidation and repair. Nature Neuroscience. 18: 836-43. PMID 25915473 DOI: 10.1038/nn.4008  1
2015 Raposo M, Bettencourt C, Maciel P, Gao F, Ramos A, Kazachkova N, Vasconcelos J, Kay T, Rodrigues AJ, Bettencourt B, Bruges-Armas J, Geschwind D, Coppola G, Lima M. Novel candidate blood-based transcriptional biomarkers of machado-joseph disease. Movement Disorders : Official Journal of the Movement Disorder Society. 30: 968-75. PMID 25914309 DOI: 10.1002/mds.26238  1
2015 Geschwind DH, State MW. Gene hunting in autism spectrum disorder: on the path to precision medicine. The Lancet. Neurology. PMID 25891009 DOI: 10.1016/S1474-4422(15)00044-7  1
2015 Winden KD, Bragin A, Engel J, Geschwind DH. Molecular alterations in areas generating fast ripples in an animal model of temporal lobe epilepsy. Neurobiology of Disease. 78: 35-44. PMID 25818007 DOI: 10.1016/j.nbd.2015.02.011  1
2015 Martinez RA, Stein JL, Krostag AR, Nelson AM, Marken JS, Menon V, May RC, Yao Z, Kaykas A, Geschwind DH, Grimley JS. Genome engineering of isogenic human ES cells to model autism disorders. Nucleic Acids Research. 43: e65. PMID 25765640 DOI: 10.1093/nar/gkv164  1
2015 Lowe JK, Werling DM, Constantino JN, Cantor RM, Geschwind DH. Social responsiveness, an autism endophenotype: genomewide significant linkage to two regions on chromosome 8. The American Journal of Psychiatry. 172: 266-75. PMID 25727539 DOI: 10.1176/appi.ajp.2014.14050576  1
2015 Chen JA, Wang Q, Davis-Turak J, Li Y, Karydas AM, Hsu SC, Sears RL, Chatzopoulou D, Huang AY, Wojta KJ, Klein E, Lee J, Beekly DL, Boxer A, Faber KM, ... ... Geschwind DH, et al. A multiancestral genome-wide exome array study of Alzheimer disease, frontotemporal dementia, and progressive supranuclear palsy. Jama Neurology. 72: 414-22. PMID 25706306 DOI: 10.1001/jamaneurol.2014.4040  1
2015 Jeste SS, Geschwind DH. Developmental disorders. Current Opinion in Neurology. 28: 89-90. PMID 25695138 DOI: 10.1097/WCO.0000000000000188  1
2015 Ellegood J, Anagnostou E, Babineau BA, Crawley JN, Lin L, Genestine M, DiCicco-Bloom E, Lai JK, Foster JA, Peñagarikano O, Geschwind DH, Pacey LK, Hampson DR, Laliberté CL, Mills AA, et al. 3D visualization of the regional differences. Molecular Psychiatry. 20: 1. PMID 25648202 DOI: 10.1038/mp.2014.168  1
2015 Chen JA, Peñagarikano O, Belgard TG, Swarup V, Geschwind DH. The emerging picture of autism spectrum disorder: genetics and pathology. Annual Review of Pathology. 10: 111-44. PMID 25621659 DOI: 10.1146/annurev-pathol-012414-040405  1
2015 Peñagarikano O, Lázaro MT, Lu XH, Gordon A, Dong H, Lam HA, Peles E, Maidment NT, Murphy NP, Yang XW, Golshani P, Geschwind DH. Exogenous and evoked oxytocin restores social behavior in the Cntnap2 mouse model of autism. Science Translational Medicine. 7: 271ra8. PMID 25609168 DOI: 10.1126/scitranslmed.3010257  1
2015 Chaste P, Klei L, Sanders SJ, Hus V, Murtha MT, Lowe JK, Willsey AJ, Moreno-De-Luca D, Yu TW, Fombonne E, Geschwind D, Grice DE, Ledbetter DH, Mane SM, Martin DM, et al. A genome-wide association study of autism using the Simons Simplex Collection: Does reducing phenotypic heterogeneity in autism increase genetic homogeneity? Biological Psychiatry. 77: 775-84. PMID 25534755 DOI: 10.1016/j.biopsych.2014.09.017  1
2015 Wang LS, Naj AC, Graham RR, Crane PK, Kunkle BW, Cruchaga C, Murcia JD, Cannon-Albright L, Baldwin CT, Zetterberg H, Blennow K, Kukull WA, Faber KM, Schupf N, Norton MC, ... ... Geschwind DH, et al. Rarity of the Alzheimer disease-protective APP A673T variant in the United States. Jama Neurology. 72: 209-16. PMID 25531812 DOI: 10.1001/jamaneurol.2014.2157  1
2015 State MW, Geschwind DH. Leveraging genetics and genomics to define the causes of mental illness. Biological Psychiatry. 77: 3-5. PMID 25483342 DOI: 10.1016/j.biopsych.2014.11.003  1
2015 Ellegood J, Anagnostou E, Babineau BA, Crawley JN, Lin L, Genestine M, DiCicco-Bloom E, Lai JK, Foster JA, Peñagarikano O, Geschwind DH, Pacey LK, Hampson DR, Laliberté CL, Mills AA, et al. Clustering autism: using neuroanatomical differences in 26 mouse models to gain insight into the heterogeneity. Molecular Psychiatry. 20: 118-25. PMID 25199916 DOI: 10.1038/mp.2014.98  1
2015 Jalbrzikowski M, Lazaro MT, Gao F, Huang A, Chow C, Geschwind DH, Coppola G, Bearden CE. Transcriptome profiling of peripheral blood in 22q11.2 deletion syndrome reveals functional pathways related to psychosis and autism spectrum disorder Plos One. 10. DOI: 10.1371/journal.pone.0132542  1
2015 Werling DM, Geschwind DH. Recurrence rates provide evidence for sex-differential, familial genetic liability for autism spectrum disorders in multiplex families and twins Molecular Autism. DOI: 10.1186/s13229-015-0004-5  1
2014 Irimia M, Weatheritt RJ, Ellis JD, Parikshak NN, Gonatopoulos-Pournatzis T, Babor M, Quesnel-Vallières M, Tapial J, Raj B, O'Hanlon D, Barrios-Rodiles M, Sternberg MJ, Cordes SP, Roth FP, Wrana JL, ... Geschwind DH, et al. A highly conserved program of neuronal microexons is misregulated in autistic brains. Cell. 159: 1511-23. PMID 25525873 DOI: 10.1016/j.cell.2014.11.035  1
2014 Buxbaum JD, Bolshakova N, Brownfeld JM, Anney RJ, Bender P, Bernier R, Cook EH, Coon H, Cuccaro M, Freitag CM, Hallmayer J, Geschwind D, Klauck SM, Nurnberger JI, Oliveira G, et al. The Autism Simplex Collection: an international, expertly phenotyped autism sample for genetic and phenotypic analyses. Molecular Autism. 5: 34. PMID 25392729 DOI: 10.1186/2040-2392-5-34  1
2014 Tian Y, Voineagu I, Pa?ca SP, Won H, Chandran V, Horvath S, Dolmetsch RE, Geschwind DH. Alteration in basal and depolarization induced transcriptional network in iPSC derived neurons from Timothy syndrome. Genome Medicine. 6: 75. PMID 25360157 DOI: 10.1186/s13073-014-0075-5  1
2014 Oguro-Ando A, Rosensweig C, Herman E, Nishimura Y, Werling D, Bill BR, Berg JM, Gao F, Coppola G, Abrahams BS, Geschwind DH. Increased CYFIP1 dosage alters cellular and dendritic morphology and dysregulates mTOR. Molecular Psychiatry. PMID 25311365 DOI: 10.1038/mp.2014.124  1
2014 Lee SE, Khazenzon AM, Trujillo AJ, Guo CC, Yokoyama JS, Sha SJ, Takada LT, Karydas AM, Block NR, Coppola G, Pribadi M, Geschwind DH, Rademakers R, Fong JC, Weiner MW, et al. Altered network connectivity in frontotemporal dementia with C9orf72 hexanucleotide repeat expansion. Brain : a Journal of Neurology. 137: 3047-60. PMID 25273996 DOI: 10.1093/brain/awu248  1
2014 Fogel BL, Lee H, Deignan JL, Strom SP, Kantarci S, Wang X, Quintero-Rivera F, Vilain E, Grody WW, Perlman S, Geschwind DH, Nelson SF. Exome sequencing in the clinical diagnosis of sporadic or familial cerebellar ataxia. Jama Neurology. 71: 1237-46. PMID 25133958 DOI: 10.1001/jamaneurol.2014.1944  1
2014 Stein JL, de la Torre-Ubieta L, Tian Y, Parikshak NN, Hernández IA, Marchetto MC, Baker DK, Lu D, Hinman CR, Lowe JK, Wexler EM, Muotri AR, Gage FH, Kosik KS, Geschwind DH. A quantitative framework to evaluate modeling of cortical development by neural stem cells. Neuron. 83: 69-86. PMID 24991955 DOI: 10.1016/j.neuron.2014.05.035  1
2014 Fogel BL, Clark MC, Geschwind DH. The neurogenetics of atypical parkinsonian disorders. Seminars in Neurology. 34: 217-24. PMID 24963681 DOI: 10.1055/s-0034-1381738  1
2014 Chaste P, Sanders SJ, Mohan KN, Klei L, Song Y, Murtha MT, Hus V, Lowe JK, Willsey AJ, Moreno-De-Luca D, Yu TW, Fombonne E, Geschwind D, Grice DE, Ledbetter DH, et al. Modest impact on risk for autism spectrum disorder of rare copy number variants at 15q11.2, specifically breakpoints 1 to 2. Autism Research : Official Journal of the International Society For Autism Research. 7: 355-62. PMID 24821083 DOI: 10.1002/aur.1378  1
2014 Pinto D, Delaby E, Merico D, Barbosa M, Merikangas A, Klei L, Thiruvahindrapuram B, Xu X, Ziman R, Wang Z, Vorstman JA, Thompson A, Regan R, Pilorge M, Pellecchia G, ... ... Geschwind DH, et al. Convergence of genes and cellular pathways dysregulated in autism spectrum disorders. American Journal of Human Genetics. 94: 677-94. PMID 24768552 DOI: 10.1016/j.ajhg.2014.03.018  0.32
2014 Fogel BL, Cho E, Wahnich A, Gao F, Becherel OJ, Wang X, Fike F, Chen L, Criscuolo C, De Michele G, Filla A, Collins A, Hahn AF, Gatti RA, Konopka G, ... ... Geschwind DH, et al. Mutation of senataxin alters disease-specific transcriptional networks in patients with ataxia with oculomotor apraxia type 2. Human Molecular Genetics. 23: 4758-69. PMID 24760770 DOI: 10.1093/hmg/ddu190  1
2014 Correia CT, Conceição IC, Oliveira B, Coelho J, Sousa I, Sequeira AF, Almeida J, Café C, Duque F, Mouga S, Roberts W, Gao K, Lowe JK, Thiruvahindrapuram B, Walker S, ... ... Geschwind DH, et al. Recurrent duplications of the annexin A1 gene (ANXA1) in autism spectrum disorders. Molecular Autism. 5: 28. PMID 24720851 DOI: 10.1186/2040-2392-5-28  1
2014 Miller JA, Ding SL, Sunkin SM, Smith KA, Ng L, Szafer A, Ebbert A, Riley ZL, Royall JJ, Aiona K, Arnold JM, Bennet C, Bertagnolli D, Brouner K, Butler S, ... ... Geschwind DH, et al. Transcriptional landscape of the prenatal human brain. Nature. 508: 199-206. PMID 24695229 DOI: 10.1038/nature13185  1
2014 Geschwind D, Nestler EJ. Neurodegenerative dementias: connecting psychiatry and neurology through a shared neurobiology. Biological Psychiatry. 75: 518-9. PMID 24629667 DOI: 10.1016/j.biopsych.2014.02.007  1
2014 Li Y, Chen JA, Sears RL, Gao F, Klein ED, Karydas A, Geschwind MD, Rosen HJ, Boxer AL, Guo W, Pellegrini M, Horvath S, Miller BL, Geschwind DH, Coppola G. An epigenetic signature in peripheral blood associated with the haplotype on 17q21.31, a risk factor for neurodegenerative tauopathy. Plos Genetics. 10: e1004211. PMID 24603599 DOI: 10.1371/journal.pgen.1004211  1
2014 Werling DM, Lowe JK, Luo R, Cantor RM, Geschwind DH. Replication of linkage at chromosome 20p13 and identification of suggestive sex-differential risk loci for autism spectrum disorder. Molecular Autism. 5: 13. PMID 24533643 DOI: 10.1186/2040-2392-5-13  1
2014 Wright MC, Mi R, Connor E, Reed N, Vyas A, Alspalter M, Coppola G, Geschwind DH, Brushart TM, Höke A. Novel roles for osteopontin and clusterin in peripheral motor and sensory axon regeneration. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 34: 1689-700. PMID 24478351 DOI: 10.1523/JNEUROSCI.3822-13.2014  1
2014 Jeste SS, Geschwind DH. Disentangling the heterogeneity of autism spectrum disorder through genetic findings. Nature Reviews. Neurology. 10: 74-81. PMID 24468882 DOI: 10.1038/nrneurol.2013.278  1
2014 Belgard TG, Jankovic I, Lowe JK, Geschwind DH. Population structure confounds autism genetic classifier. Molecular Psychiatry. 19: 405-7. PMID 23546168 DOI: 10.1038/mp.2013.34  1
2014 Schwede M, Garbett K, Mirnics K, Geschwind DH, Morrow EM. Genes for endosomal NHE6 and NHE9 are misregulated in autism brains. Molecular Psychiatry. 19: 277-9. PMID 23508127 DOI: 10.1038/mp.2013.28  1
2013 Parikshak NN, Luo R, Zhang A, Won H, Lowe JK, Chandran V, Horvath S, Geschwind DH. Integrative functional genomic analyses implicate specific molecular pathways and circuits in autism. Cell. 155: 1008-21. PMID 24267887 DOI: 10.1016/j.cell.2013.10.031  1
2013 Geschwind DH, Rakic P. Cortical evolution: judge the brain by its cover. Neuron. 80: 633-47. PMID 24183016 DOI: 10.1016/j.neuron.2013.10.045  1
2013 van Blitterswijk M, Baker MC, DeJesus-Hernandez M, Ghidoni R, Benussi L, Finger E, Hsiung GY, Kelley BJ, Murray ME, Rutherford NJ, Brown PE, Ravenscroft T, Mullen B, Ash PE, Bieniek KF, ... ... Geschwind DH, et al. C9ORF72 repeat expansions in cases with previously identified pathogenic mutations. Neurology. 81: 1332-41. PMID 24027057 DOI: 10.1212/WNL.0b013e3182a8250c  1
2013 Lee SH, Ripke S, Neale BM, Faraone SV, Purcell SM, Perlis RH, Mowry BJ, Thapar A, Goddard ME, Witte JS, Absher D, Agartz I, Akil H, Amin F, ... ... Geschwind DH, et al. Genetic relationship between five psychiatric disorders estimated from genome-wide SNPs. Nature Genetics. 45: 984-94. PMID 23933821 DOI: 10.1038/ng.2711  0.32
2013 Keller A, Westenberger A, Sobrido MJ, García-Murias M, Domingo A, Sears RL, Lemos RR, Ordoñez-Ugalde A, Nicolas G, da Cunha JE, Rushing EJ, Hugelshofer M, Wurnig MC, Kaech A, Reimann R, ... ... Geschwind DH, et al. Mutations in the gene encoding PDGF-B cause brain calcifications in humans and mice. Nature Genetics. 45: 1077-82. PMID 23913003 DOI: 10.1038/ng.2723  1
2013 Swarup V, Geschwind DH. Alzheimer's disease: From big data to mechanism. Nature. 500: 34-5. PMID 23883924 DOI: 10.1038/nature12457  1
2013 Gamsiz ED, Viscidi EW, Frederick AM, Nagpal S, Sanders SJ, Murtha MT, Schmidt M, Triche EW, Geschwind DH, State MW, Istrail S, Cook EH, Devlin B, Morrow EM. Intellectual disability is associated with increased runs of homozygosity in simplex autism. American Journal of Human Genetics. 93: 103-9. PMID 23830515 DOI: 10.1016/j.ajhg.2013.06.004  1
2013 Chaste P, Klei L, Sanders SJ, Murtha MT, Hus V, Lowe JK, Willsey AJ, Moreno-De-Luca D, Yu TW, Fombonne E, Geschwind D, Grice DE, Ledbetter DH, Lord C, Mane SM, et al. Adjusting head circumference for covariates in autism: clinical correlates of a highly heritable continuous trait. Biological Psychiatry. 74: 576-84. PMID 23746936 DOI: 10.1016/j.biopsych.2013.04.018  1
2013 Miller JA, Woltjer RL, Goodenbour JM, Horvath S, Geschwind DH. Genes and pathways underlying regional and cell type changes in Alzheimer's disease. Genome Medicine. 5: 48. PMID 23705665 DOI: 10.1186/gm452  1
2013 Juknat A, Pietr M, Kozela E, Rimmerman N, Levy R, Gao F, Coppola G, Geschwind D, Vogel Z. Microarray and pathway analysis reveal distinct mechanisms underlying cannabinoid-mediated modulation of LPS-induced activation of BV-2 microglial cells. Plos One. 8: e61462. PMID 23637839 DOI: 10.1371/journal.pone.0061462  1
2013 Perry DC, Lehmann M, Yokoyama JS, Karydas A, Lee JJ, Coppola G, Grinberg LT, Geschwind D, Seeley WW, Miller BL, Rosen H, Rabinovici G. Progranulin mutations as risk factors for Alzheimer disease. Jama Neurology. 70: 774-8. PMID 23609919 DOI: 10.1001/2013.jamaneurol.393  1
2013 Miller ZA, Rankin KP, Graff-Radford NR, Takada LT, Sturm VE, Cleveland CM, Criswell LA, Jaeger PA, Stan T, Heggeli KA, Hsu SC, Karydas A, Khan BK, Grinberg LT, Gorno-Tempini ML, ... ... Geschwind DH, et al. TDP-43 frontotemporal lobar degeneration and autoimmune disease. Journal of Neurology, Neurosurgery, and Psychiatry. 84: 956-62. PMID 23543794 DOI: 10.1136/jnnp-2012-304644  1
2013 Lee SE, Tartaglia MC, Yener G, Genç S, Seeley WW, Sanchez-Juan P, Moreno F, Mendez MF, Klein E, Rademakers R, López de Munain A, Combarros O, Kramer JH, Kenet RO, Boxer AL, ... ... Geschwind DH, et al. Neurodegenerative disease phenotypes in carriers of MAPT p.A152T, a risk factor for frontotemporal dementia spectrum disorders and Alzheimer disease. Alzheimer Disease and Associated Disorders. 27: 302-9. PMID 23518664 DOI: 10.1097/WAD.0b013e31828cc357  1
2013 Yamada T, Yang Y, Huang J, Coppola G, Geschwind DH, Bonni A. Sumoylated MEF2A coordinately eliminates orphan presynaptic sites and promotes maturation of presynaptic boutons. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 33: 4726-40. PMID 23486945 DOI: 10.1523/JNEUROSCI.4191-12.2013  1
2013 Werling DM, Geschwind DH. Understanding sex bias in autism spectrum disorder. Proceedings of the National Academy of Sciences of the United States of America. 110: 4868-9. PMID 23476067 DOI: 10.1073/pnas.1301602110  1
2013 Dougherty JD, Maloney SE, Wozniak DF, Rieger MA, Sonnenblick L, Coppola G, Mahieu NG, Zhang J, Cai J, Patti GJ, Abrahams BS, Geschwind DH, Heintz N. The disruption of Celf6, a gene identified by translational profiling of serotonergic neurons, results in autism-related behaviors. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 33: 2732-53. PMID 23407934 DOI: 10.1523/JNEUROSCI.4762-12.2013  1
2013 Werling DM, Geschwind DH. Sex differences in autism spectrum disorders. Current Opinion in Neurology. 26: 146-53. PMID 23406909 DOI: 10.1097/WCO.0b013e32835ee548  1
2013 Fogel BL, Baker C, Curnow A, Perlman SL, Geschwind DH, Coppola G. Mutations in PDYN are not responsible for multiple system atrophy. Journal of Neurology. 260: 927-8. PMID 23355175 DOI: 10.1007/s00415-012-6830-x  1
2013 Stein JL, Parikshak NN, Geschwind DH. Rare inherited variation in autism: beginning to see the forest and a few trees. Neuron. 77: 209-11. PMID 23352155 DOI: 10.1016/j.neuron.2013.01.010  1
2013 Hsu SC, Sears RL, Lemos RR, Quintáns B, Huang A, Spiteri E, Nevarez L, Mamah C, Zatz M, Pierce KD, Fullerton JM, Adair JC, Berner JE, Bower M, Brodaty H, ... ... Geschwind DH, et al. Mutations in SLC20A2 are a major cause of familial idiopathic basal ganglia calcification. Neurogenetics. 14: 11-22. PMID 23334463 DOI: 10.1007/s10048-012-0349-2  1
2013 Belgard TG, Geschwind DH. Retooling spare parts: gene duplication and cognition. Nature Neuroscience. 16: 6-8. PMID 23257927 DOI: 10.1038/nn.3292  1
2013 Moreno-De-Luca D, Sanders SJ, Willsey AJ, Mulle JG, Lowe JK, Geschwind DH, State MW, Martin CL, Ledbetter DH. Using large clinical data sets to infer pathogenicity for rare copy number variants in autism cohorts. Molecular Psychiatry. 18: 1090-5. PMID 23044707 DOI: 10.1038/mp.2012.138  1
2013 Lunnon K, Sattlecker M, Furney SJ, Coppola G, Simmons A, Proitsi P, Lupton MK, Lourdusamy A, Johnston C, Soininen H, K?oszewska I, Mecocci P, Tsolaki M, Vellas B, Geschwind D, et al. A blood gene expression marker of early Alzheimer's disease. Journal of Alzheimer's Disease : Jad. 33: 737-53. PMID 23042217 DOI: 10.3233/JAD-2012-121363  1
2013 Braskie MN, Medina LD, Rodriguez-Agudelo Y, Geschwind DH, Macias-Islas MA, Thompson PM, Cummings JL, Bookheimer SY, Ringman JM. Memory performance and fMRI signal in presymptomatic familial Alzheimer's disease. Human Brain Mapping. 34: 3308-19. PMID 22806961 DOI: 10.1002/hbm.22141  1
2013 Constantino JN, Todorov A, Hilton C, Law P, Zhang Y, Molloy E, Fitzgerald R, Geschwind D. Autism recurrence in half siblings: strong support for genetic mechanisms of transmission in ASD. Molecular Psychiatry. 18: 137-8. PMID 22371046 DOI: 10.1038/mp.2012.9  1
2013 Lu AT, Yoon J, Geschwind DH, Cantor RM. QTL replication and targeted association highlight the nerve growth factor gene for nonverbal communication deficits in autism spectrum disorders. Molecular Psychiatry. 18: 226-35. PMID 22105621 DOI: 10.1038/mp.2011.155  1
2013 Parikshak NN, Geschwind DH. Neuroscience and the Genomic Revolution: An Overview Genomic and Personalized Medicine. 2: 1018-1027. DOI: 10.1016/B978-0-12-382227-7.00084-7  1
2012 Fogel BL, Pribadi M, Pi S, Perlman SL, Geschwind DH, Coppola G. C9ORF72 expansion is not a significant cause of sporadic spinocerebellar ataxia. Movement Disorders : Official Journal of the Movement Disorder Society. 27: 1832-3. PMID 23080112 DOI: 10.1002/mds.25245  1
2012 Hamby ME, Coppola G, Ao Y, Geschwind DH, Khakh BS, Sofroniew MV. Inflammatory mediators alter the astrocyte transcriptome and calcium signaling elicited by multiple G-protein-coupled receptors. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 32: 14489-510. PMID 23077035 DOI: 10.1523/JNEUROSCI.1256-12.2012  1
2012 Klei L, Sanders SJ, Murtha MT, Hus V, Lowe JK, Willsey AJ, Moreno-De-Luca D, Yu TW, Fombonne E, Geschwind D, Grice DE, Ledbetter DH, Lord C, Mane SM, Martin CL, et al. Common genetic variants, acting additively, are a major source of risk for autism. Molecular Autism. 3: 9. PMID 23067556 DOI: 10.1186/2040-2392-3-9  1
2012 Almeida S, Zhang Z, Coppola G, Mao W, Futai K, Karydas A, Geschwind MD, Tartaglia MC, Gao F, Gianni D, Sena-Esteves M, Geschwind DH, Miller BL, Farese RV, Gao FB. Induced pluripotent stem cell models of progranulin-deficient frontotemporal dementia uncover specific reversible neuronal defects. Cell Reports. 2: 789-98. PMID 23063362 DOI: 10.1016/j.celrep.2012.09.007  1
2012 Hawrylycz MJ, Lein ES, Guillozet-Bongaarts AL, Shen EH, Ng L, Miller JA, van de Lagemaat LN, Smith KA, Ebbert A, Riley ZL, Abajian C, Beckmann CF, Bernard A, Bertagnolli D, Boe AF, ... ... Geschwind DH, et al. An anatomically comprehensive atlas of the adult human brain transcriptome. Nature. 489: 391-9. PMID 22996553 DOI: 10.1038/nature11405  1
2012 Rudie JD, Hernandez LM, Brown JA, Beck-Pancer D, Colich NL, Gorrindo P, Thompson PM, Geschwind DH, Bookheimer SY, Levitt P, Dapretto M. Autism-associated promoter variant in MET impacts functional and structural brain networks. Neuron. 75: 904-15. PMID 22958829 DOI: 10.1016/j.neuron.2012.07.010  1
2012 Russell JF, Steckley JL, Coppola G, Hahn AF, Howard MA, Kornberg Z, Huang A, Mirsattari SM, Merriman B, Klein E, Choi M, Lee HY, Kirk A, Nelson-Williams C, Gibson G, ... ... Geschwind DH, et al. Familial cortical myoclonus with a mutation in NOL3. Annals of Neurology. 72: 175-83. PMID 22926851 DOI: 10.1002/ana.23666  1
2012 Zeng J, Konopka G, Hunt BG, Preuss TM, Geschwind D, Yi SV. Divergent whole-genome methylation maps of human and chimpanzee brains reveal epigenetic basis of human regulatory evolution. American Journal of Human Genetics. 91: 455-65. PMID 22922032 DOI: 10.1016/j.ajhg.2012.07.024  1
2012 Konopka G, Friedrich T, Davis-Turak J, Winden K, Oldham MC, Gao F, Chen L, Wang GZ, Luo R, Preuss TM, Geschwind DH. Human-specific transcriptional networks in the brain. Neuron. 75: 601-17. PMID 22920253 DOI: 10.1016/j.neuron.2012.05.034  1
2012 Marques F, Mesquita SD, Sousa JC, Coppola G, Gao F, Geschwind DH, Columba-Cabezas S, Aloisi F, Degn M, Cerqueira JJ, Sousa N, Correia-Neves M, Palha JA. Lipocalin 2 is present in the EAE brain and is modulated by natalizumab. Frontiers in Cellular Neuroscience. 6: 33. PMID 22907989 DOI: 10.3389/fncel.2012.00033  1
2012 Sha SJ, Takada LT, Rankin KP, Yokoyama JS, Rutherford NJ, Fong JC, Khan B, Karydas A, Baker MC, DeJesus-Hernandez M, Pribadi M, Coppola G, Geschwind DH, Rademakers R, Lee SE, et al. Frontotemporal dementia due to C9ORF72 mutations: clinical and imaging features. Neurology. 79: 1002-11. PMID 22875087 DOI: 10.1212/WNL.0b013e318268452e  1
2012 Berg JM, Geschwind DH. Autism genetics: searching for specificity and convergence. Genome Biology. 13: 247. PMID 22849751 DOI: 10.1186/gb4034  1
2012 Anney R, Klei L, Pinto D, Almeida J, Bacchelli E, Baird G, Bolshakova N, Bölte S, Bolton PF, Bourgeron T, Brennan S, Brian J, Casey J, Conroy J, Correia C, ... ... Geschwind DH, et al. Individual common variants exert weak effects on the risk for autism spectrum disorderspi. Human Molecular Genetics. 21: 4781-92. PMID 22843504 DOI: 10.1093/hmg/dds301  0.32
2012 Perry RB, Doron-Mandel E, Iavnilovitch E, Rishal I, Dagan SY, Tsoory M, Coppola G, McDonald MK, Gomes C, Geschwind DH, Twiss JL, Yaron A, Fainzilber M. Subcellular knockout of importin β1 perturbs axonal retrograde signaling. Neuron. 75: 294-305. PMID 22841314 DOI: 10.1016/j.neuron.2012.05.033  1
2012 Shirasaki DI, Greiner ER, Al-Ramahi I, Gray M, Boontheung P, Geschwind DH, Botas J, Coppola G, Horvath S, Loo JA, Yang XW. Network organization of the huntingtin proteomic interactome in mammalian brain. Neuron. 75: 41-57. PMID 22794259 DOI: 10.1016/j.neuron.2012.05.024  1
2012 Fogel BL, Wexler E, Wahnich A, Friedrich T, Vijayendran C, Gao F, Parikshak N, Konopka G, Geschwind DH. RBFOX1 regulates both splicing and transcriptional networks in human neuronal development. Human Molecular Genetics. 21: 4171-86. PMID 22730494 DOI: 10.1093/hmg/dds240  1
2012 Luo R, Sanders SJ, Tian Y, Voineagu I, Huang N, Chu SH, Klei L, Cai C, Ou J, Lowe JK, Hurles ME, Devlin B, State MW, Geschwind DH. Genome-wide transcriptome profiling reveals the functional impact of rare de novo and recurrent CNVs in autism spectrum disorders. American Journal of Human Genetics. 91: 38-55. PMID 22726847 DOI: 10.1016/j.ajhg.2012.05.011  1
2012 Geschwind DH, Konopka G. Neuroscience: Genes and human brain evolution. Nature. 486: 481-2. PMID 22722844 DOI: 10.1038/nature11380  1
2012 Ringman JM, Elashoff D, Geschwind DH, Welsh BT, Gylys KH, Lee C, Cummings JL, Cole GM. Plasma signaling proteins in persons at genetic risk for Alzheimer disease: influence of APOE genotype. Archives of Neurology. 69: 757-64. PMID 22689192 DOI: 10.1001/archneurol.2012.277  1
2012 Coppola G, Geschwind DH. Genomic medicine enters the neurology clinic. Neurology. 79: 112-4. PMID 22675078 DOI: 10.1212/WNL.0b013e31825f06d9  1
2012 Karayiorgou M, Flint J, Gogos JA, Malenka RC. The best of times, the worst of times for psychiatric disease. Nature Neuroscience. 15: 811-2. PMID 22627793 DOI: 10.1038/nn.3115  1
2012 Celestino-Soper PB, Violante S, Crawford EL, Luo R, Lionel AC, Delaby E, Cai G, Sadikovic B, Lee K, Lo C, Gao K, Person RE, Moss TJ, German JR, Huang N, ... ... Geschwind DH, et al. A common X-linked inborn error of carnitine biosynthesis may be a risk factor for nondysmorphic autism. Proceedings of the National Academy of Sciences of the United States of America. 109: 7974-81. PMID 22566635 DOI: 10.1073/pnas.1120210109  1
2012 Coppola G, Chinnathambi S, Lee JJ, Dombroski BA, Baker MC, Soto-Ortolaza AI, Lee SE, Klein E, Huang AY, Sears R, Lane JR, Karydas AM, Kenet RO, Biernat J, Wang LS, ... ... Geschwind DH, et al. Evidence for a role of the rare p.A152T variant in MAPT in increasing the risk for FTD-spectrum and Alzheimer's diseases. Human Molecular Genetics. 21: 3500-12. PMID 22556362 DOI: 10.1093/hmg/dds161  0.48
2012 Sanders SJ, Murtha MT, Gupta AR, Murdoch JD, Raubeson MJ, Willsey AJ, Ercan-Sencicek AG, DiLullo NM, Parikshak NN, Stein JL, Walker MF, Ober GT, Teran NA, Song Y, El-Fishawy P, ... ... Geschwind DH, et al. De novo mutations revealed by whole-exome sequencing are strongly associated with autism. Nature. 485: 237-41. PMID 22495306 DOI: 10.1038/nature10945  1
2012 Lunnon K, Ibrahim Z, Proitsi P, Lourdusamy A, Newhouse S, Sattlecker M, Furney S, Saleem M, Soininen H, K?oszewska I, Mecocci P, Tsolaki M, Vellas B, Coppola G, Geschwind D, et al. Mitochondrial dysfunction and immune activation are detectable in early Alzheimer's disease blood. Journal of Alzheimer's Disease : Jad. 30: 685-710. PMID 22466004 DOI: 10.3233/JAD-2012-111592  1
2012 Bernard A, Lubbers LS, Tanis KQ, Luo R, Podtelezhnikov AA, Finney EM, McWhorter MM, Serikawa K, Lemon T, Morgan R, Copeland C, Smith K, Cullen V, Davis-Turak J, Lee CK, ... ... Geschwind DH, et al. Transcriptional architecture of the primate neocortex. Neuron. 73: 1083-99. PMID 22445337 DOI: 10.1016/j.neuron.2012.03.002  1
2012 Khan BK, Yokoyama JS, Takada LT, Sha SJ, Rutherford NJ, Fong JC, Karydas AM, Wu T, Ketelle RS, Baker MC, Hernandez MD, Coppola G, Geschwind DH, Rademakers R, Lee SE, et al. Atypical, slowly progressive behavioural variant frontotemporal dementia associated with C9ORF72 hexanucleotide expansion. Journal of Neurology, Neurosurgery, and Psychiatry. 83: 358-64. PMID 22399793 DOI: 10.1136/jnnp-2011-301883  1
2012 Peñagarikano O, Geschwind DH. What does CNTNAP2 reveal about autism spectrum disorder? Trends in Molecular Medicine. 18: 156-63. PMID 22365836 DOI: 10.1016/j.molmed.2012.01.003  1
2012 Fogel BL, Lee JY, Lane J, Wahnich A, Chan S, Huang A, Osborn GE, Klein E, Mamah C, Perlman S, Geschwind DH, Coppola G. Mutations in rare ataxia genes are uncommon causes of sporadic cerebellar ataxia. Movement Disorders : Official Journal of the Movement Disorder Society. 27: 442-6. PMID 22287014 DOI: 10.1002/mds.24064  1
2012 Ringman JM, Schulman H, Becker C, Jones T, Bai Y, Immermann F, Cole G, Sokolow S, Gylys K, Geschwind DH, Cummings JL, Wan HI. Proteomic changes in cerebrospinal fluid of presymptomatic and affected persons carrying familial Alzheimer disease mutations. Archives of Neurology. 69: 96-104. PMID 22232349 DOI: 10.1001/archneurol.2011.642  1
2012 Blesch A, Lu P, Tsukada S, Alto LT, Roet K, Coppola G, Geschwind D, Tuszynski MH. Conditioning lesions before or after spinal cord injury recruit broad genetic mechanisms that sustain axonal regeneration: superiority to camp-mediated effects. Experimental Neurology. 235: 162-73. PMID 22227059 DOI: 10.1016/j.expneurol.2011.12.037  1
2012 Casey JP, Magalhaes T, Conroy JM, Regan R, Shah N, Anney R, Shields DC, Abrahams BS, Almeida J, Bacchelli E, Bailey AJ, Baird G, Battaglia A, Berney T, Bolshakova N, ... ... Geschwind DH, et al. A novel approach of homozygous haplotype sharing identifies candidate genes in autism spectrum disorder. Human Genetics. 131: 565-79. PMID 21996756 DOI: 10.1007/s00439-011-1094-6  0.72
2012 Voineagu I, Huang L, Winden K, Lazaro M, Haan E, Nelson J, McGaughran J, Nguyen LS, Friend K, Hackett A, Field M, Gecz J, Geschwind D. CCDC22: a novel candidate gene for syndromic X-linked intellectual disability. Molecular Psychiatry. 17: 4-7. PMID 21826058 DOI: 10.1038/mp.2011.95  1
2012 Konopka G, Wexler E, Rosen E, Mukamel Z, Osborn GE, Chen L, Lu D, Gao F, Gao K, Lowe JK, Geschwind DH. Modeling the functional genomics of autism using human neurons. Molecular Psychiatry. 17: 202-14. PMID 21647150 DOI: 10.1038/mp.2011.60  1
2012 Juknat A, Pietr M, Kozela E, Rimmerman N, Levy R, Coppola G, Geschwind D, Vogel Z. Differential transcriptional profiles mediated by exposure to the cannabinoids cannabidiol and Δ9-tetrahydrocannabinol in BV-2 microglial cells. British Journal of Pharmacology. 165: 2512-28. PMID 21542829 DOI: 10.1111/j.1476-5381.2011.01461.x  1
2012 Braskie MN, Medina LD, Rodriguez-Agudelo Y, Geschwind DH, Macias-Islas MA, Cummings JL, Bookheimer SY, Ringman JM. Increased fMRI signal with age in familial Alzheimer's disease mutation carriers. Neurobiology of Aging. 33: 424.e11-21. PMID 21129823 DOI: 10.1016/j.neurobiolaging.2010.09.028  1
2012 Ehninger D, Sano Y, de Vries PJ, Dies K, Franz D, Geschwind DH, Kaur M, Lee YS, Li W, Lowe JK, Nakagawa JA, Sahin M, Smith K, Whittemore V, Silva AJ. Gestational immune activation and Tsc2 haploinsufficiency cooperate to disrupt fetal survival and may perturb social behavior in adult mice. Molecular Psychiatry. 17: 62-70. PMID 21079609 DOI: 10.1038/mp.2010.115  1
2012 Ehninger D, Sano Y, De Vries PJ, Dies K, Franz D, Geschwind DH, Kaur M, Lee YS, Li W, Lowe JK, Nakagawa JA, Sahin M, Smith K, Whittemore V, Silva AJ. Gestational immune activation and Tsc2 haploinsufficiency cooperate to disrupt fetal survival and may perturb social behavior in adult mice (Molecular Psychiatry (2012) 17, (62-70) DOI:10.1038/mp.2010.115) Molecular Psychiatry. 17: 469-470. DOI: 10.1038/mp.2011.39  1
2011 Coppola G, Burnett R, Perlman S, Versano R, Gao F, Plasterer H, Rai M, Saccá F, Filla A, Lynch DR, Rusche JR, Gottesfeld JM, Pandolfo M, Geschwind DH. A gene expression phenotype in lymphocytes from Friedreich ataxia patients. Annals of Neurology. 70: 790-804. PMID 22162061 DOI: 10.1002/ana.22526  1
2011 Medina LD, Rodriguez-Agudelo Y, Geschwind DH, Gilbert PE, Liang LJ, Cummings JL, Ringman JM. Propositional density and apolipoprotein E genotype among persons at risk for familial Alzheimer's disease. Dementia and Geriatric Cognitive Disorders. 32: 188-92. PMID 22134129 DOI: 10.1159/000333023  1
2011 Pa?ca SP, Portmann T, Voineagu I, Yazawa M, Shcheglovitov A, Pa?ca AM, Cord B, Palmer TD, Chikahisa S, Nishino S, Bernstein JA, Hallmayer J, Geschwind DH, Dolmetsch RE. Using iPSC-derived neurons to uncover cellular phenotypes associated with Timothy syndrome. Nature Medicine. 17: 1657-62. PMID 22120178 DOI: 10.1038/nm.2576  1
2011 Wexler EM, Geschwind DH. DISC1: a schizophrenia gene with multiple personalities. Neuron. 72: 501-3. PMID 22099453 DOI: 10.1016/j.neuron.2011.10.023  1
2011 Wexler EM, Rosen E, Lu D, Osborn GE, Martin E, Raybould H, Geschwind DH. Genome-wide analysis of a Wnt1-regulated transcriptional network implicates neurodegenerative pathways. Science Signaling. 4: ra65. PMID 21971039 DOI: 10.1126/scisignal.2002282  1
2011 Ma CH, Omura T, Cobos EJ, Latrémolière A, Ghasemlou N, Brenner GJ, van Veen E, Barrett L, Sawada T, Gao F, Coppola G, Gertler F, Costigan M, Geschwind D, Woolf CJ. Accelerating axonal growth promotes motor recovery after peripheral nerve injury in mice. The Journal of Clinical Investigation. 121: 4332-47. PMID 21965333 DOI: 10.1172/JCI58675  1
2011 Peñagarikano O, Abrahams BS, Herman EI, Winden KD, Gdalyahu A, Dong H, Sonnenblick LI, Gruver R, Almajano J, Bragin A, Golshani P, Trachtenberg JT, Peles E, Geschwind DH. Absence of CNTNAP2 leads to epilepsy, neuronal migration abnormalities, and core autism-related deficits. Cell. 147: 235-46. PMID 21962519 DOI: 10.1016/j.cell.2011.08.040  1
2011 Apostolova LG, Hwang KS, Medina LD, Green AE, Braskie MN, Dutton RA, Lai J, Geschwind DH, Cummings JL, Thompson PM, Ringman JM. Cortical and hippocampal atrophy in patients with autosomal dominant familial Alzheimer's disease. Dementia and Geriatric Cognitive Disorders. 32: 118-25. PMID 21952501 DOI: 10.1159/000330471  1
2011 DeJesus-Hernandez M, Mackenzie IR, Boeve BF, Boxer AL, Baker M, Rutherford NJ, Nicholson AM, Finch NA, Flynn H, Adamson J, Kouri N, Wojtas A, Sengdy P, Hsiung GY, Karydas A, ... ... Geschwind DH, et al. Expanded GGGGCC hexanucleotide repeat in noncoding region of C9ORF72 causes chromosome 9p-linked FTD and ALS. Neuron. 72: 245-56. PMID 21944778 DOI: 10.1016/j.neuron.2011.09.011  1
2011 Rosen EY, Wexler EM, Versano R, Coppola G, Gao F, Winden KD, Oldham MC, Martens LH, Zhou P, Farese RV, Geschwind DH. Functional genomic analyses identify pathways dysregulated by progranulin deficiency, implicating Wnt signaling. Neuron. 71: 1030-42. PMID 21943601 DOI: 10.1016/j.neuron.2011.07.021  1
2011 Geschwind DH. Genetics of autism spectrum disorders. Trends in Cognitive Sciences. 15: 409-16. PMID 21855394 DOI: 10.1016/j.tics.2011.07.003  1
2011 Mukamel Z, Konopka G, Wexler E, Osborn GE, Dong H, Bergman MY, Levitt P, Geschwind DH. Regulation of MET by FOXP2, genes implicated in higher cognitive dysfunction and autism risk. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 31: 11437-42. PMID 21832174 DOI: 10.1523/JNEUROSCI.0181-11.2011  1
2011 Miller JA, Cai C, Langfelder P, Geschwind DH, Kurian SM, Salomon DR, Horvath S. Strategies for aggregating gene expression data: the collapseRows R function. Bmc Bioinformatics. 12: 322. PMID 21816037 DOI: 10.1186/1471-2105-12-322  1
2011 Vernes SC, Oliver PL, Spiteri E, Lockstone HE, Puliyadi R, Taylor JM, Ho J, Mombereau C, Brewer A, Lowy E, Nicod J, Groszer M, Baban D, Sahgal N, Cazier JB, ... ... Geschwind DH, et al. Foxp2 regulates gene networks implicated in neurite outgrowth in the developing brain. Plos Genetics. 7: e1002145. PMID 21765815 DOI: 10.1371/journal.pgen.1002145  1
2011 Winden KD, Karsten SL, Bragin A, Kudo LC, Gehman L, Ruidera J, Geschwind DH, Engel J. A systems level, functional genomics analysis of chronic epilepsy. Plos One. 6: e20763. PMID 21695113 DOI: 10.1371/journal.pone.0020763  1
2011 Dolmetsch R, Geschwind DH. The human brain in a dish: the promise of iPSC-derived neurons. Cell. 145: 831-4. PMID 21663789 DOI: 10.1016/j.cell.2011.05.034  1
2011 Sanders SJ, Ercan-Sencicek AG, Hus V, Luo R, Murtha MT, Moreno-De-Luca D, Chu SH, Moreau MP, Gupta AR, Thomson SA, Mason CE, Bilguvar K, Celestino-Soper PB, Choi M, Crawford EL, ... ... Geschwind D, et al. Multiple recurrent de novo CNVs, including duplications of the 7q11.23 Williams syndrome region, are strongly associated with autism. Neuron. 70: 863-85. PMID 21658581 DOI: 10.1016/j.neuron.2011.05.002  1
2011 Voineagu I, Wang X, Johnston P, Lowe JK, Tian Y, Horvath S, Mill J, Cantor RM, Blencowe BJ, Geschwind DH. Transcriptomic analysis of autistic brain reveals convergent molecular pathology. Nature. 474: 380-4. PMID 21614001 DOI: 10.1038/nature10110  1
2011 Sleiman SF, Langley BC, Basso M, Berlin J, Xia L, Payappilly JB, Kharel MK, Guo H, Marsh JL, Thompson LM, Mahishi L, Ahuja P, MacLellan WR, Geschwind DH, Coppola G, et al. Mithramycin is a gene-selective Sp1 inhibitor that identifies a biological intersection between cancer and neurodegeneration. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 31: 6858-70. PMID 21543616 DOI: 10.1523/JNEUROSCI.0710-11.2011  1
2011 Zai L, Ferrari C, Dice C, Subbaiah S, Havton LA, Coppola G, Geschwind D, Irwin N, Huebner E, Strittmatter SM, Benowitz LI. Inosine augments the effects of a Nogo receptor blocker and of environmental enrichment to restore skilled forelimb use after stroke. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 31: 5977-88. PMID 21508223 DOI: 10.1523/JNEUROSCI.4498-10.2011  1
2011 Iwamoto K, Bundo M, Ueda J, Oldham MC, Ukai W, Hashimoto E, Saito T, Geschwind DH, Kato T. Neurons show distinctive DNA methylation profile and higher interindividual variations compared with non-neurons. Genome Research. 21: 688-96. PMID 21467265 DOI: 10.1101/gr.112755.110  0.68
2011 Naj AC, Jun G, Beecham GW, Wang LS, Vardarajan BN, Buros J, Gallins PJ, Buxbaum JD, Jarvik GP, Crane PK, Larson EB, Bird TD, Boeve BF, Graff-Radford NR, De Jager PL, ... ... Geschwind DH, et al. Common variants at MS4A4/MS4A6E, CD2AP, CD33 and EPHA1 are associated with late-onset Alzheimer's disease. Nature Genetics. 43: 436-41. PMID 21460841 DOI: 10.1038/ng.801  1
2011 Cenik B, Sephton CF, Dewey CM, Xian X, Wei S, Yu K, Niu W, Coppola G, Coughlin SE, Lee SE, Dries DR, Almeida S, Geschwind DH, Gao FB, Miller BL, et al. Suberoylanilide hydroxamic acid (vorinostat) up-regulates progranulin transcription: rational therapeutic approach to frontotemporal dementia. The Journal of Biological Chemistry. 286: 16101-8. PMID 21454553 DOI: 10.1074/jbc.M110.193433  1
2011 Marques F, Sousa JC, Coppola G, Gao F, Puga R, Brentani H, Geschwind DH, Sousa N, Correia-Neves M, Palha JA. Transcriptome signature of the adult mouse choroid plexus. Fluids and Barriers of the Cns. 8: 10. PMID 21349147 DOI: 10.1186/2045-8118-8-10  0.36
2011 Tang B, Seredenina T, Coppola G, Kuhn A, Geschwind DH, Luthi-Carter R, Thomas EA. Gene expression profiling of R6/2 transgenic mice with different CAG repeat lengths reveals genes associated with disease onset and progression in Huntington's disease. Neurobiology of Disease. 42: 459-67. PMID 21334439 DOI: 10.1016/j.nbd.2011.02.008  1
2011 Becker EB, Fogel BL, Rajakulendran S, Dulneva A, Hanna MG, Perlman SL, Geschwind DH, Davies KE. Candidate screening of the TRPC3 gene in cerebellar ataxia. Cerebellum (London, England). 10: 296-9. PMID 21321808 DOI: 10.1007/s12311-011-0253-6  1
2011 Newbern JM, Li X, Shoemaker SE, Zhou J, Zhong J, Wu Y, Bonder D, Hollenback S, Coppola G, Geschwind DH, Landreth GE, Snider WD. Specific functions for ERK/MAPK signaling during PNS development. Neuron. 69: 91-105. PMID 21220101 DOI: 10.1016/j.neuron.2010.12.003  1
2011 Finch N, Carrasquillo MM, Baker M, Rutherford NJ, Coppola G, Dejesus-Hernandez M, Crook R, Hunter T, Ghidoni R, Benussi L, Crook J, Finger E, Hantanpaa KJ, Karydas AM, Sengdy P, ... ... Geschwind DH, et al. TMEM106B regulates progranulin levels and the penetrance of FTLD in GRN mutation carriers. Neurology. 76: 467-74. PMID 21178100 DOI: 10.1212/WNL.0b013e31820a0e3b  1
2011 Thomas EA, Coppola G, Tang B, Kuhn A, Kim S, Geschwind DH, Brown TB, Luthi-Carter R, Ehrlich ME. In vivo cell-autonomous transcriptional abnormalities revealed in mice expressing mutant huntingtin in striatal but not cortical neurons. Human Molecular Genetics. 20: 1049-60. PMID 21177255 DOI: 10.1093/hmg/ddq548  1
2011 Lu PH, Thompson PM, Leow A, Lee GJ, Lee A, Yanovsky I, Parikshak N, Khoo T, Wu S, Geschwind D, Bartzokis G. Apolipoprotein E genotype is associated with temporal and hippocampal atrophy rates in healthy elderly adults: a tensor-based morphometry study. Journal of Alzheimer's Disease : Jad. 23: 433-42. PMID 21098974 DOI: 10.3233/JAD-2010-101398  1
2011 Ringman JM, Medina LD, Braskie M, Rodriguez-Agudelo Y, Geschwind DH, Macias-Islas MA, Cummings JL, Bookheimer S. Effects of risk genes on BOLD activation in presymptomatic carriers of familial Alzheimer's disease mutations during a novelty encoding task. Cerebral Cortex (New York, N.Y. : 1991). 21: 877-83. PMID 20729396 DOI: 10.1093/cercor/bhq158  1
2010 Li S, Overman JJ, Katsman D, Kozlov SV, Donnelly CJ, Twiss JL, Giger RJ, Coppola G, Geschwind DH, Carmichael ST. An age-related sprouting transcriptome provides molecular control of axonal sprouting after stroke. Nature Neuroscience. 13: 1496-504. PMID 21057507 DOI: 10.1038/nn.2674  1
2010 Scott-Van Zeeland AA, Abrahams BS, Alvarez-Retuerto AI, Sonnenblick LI, Rudie JD, Ghahremani D, Mumford JA, Poldrack RA, Dapretto M, Geschwind DH, Bookheimer SY. Altered functional connectivity in frontal lobe circuits is associated with variation in the autism risk gene CNTNAP2. Science Translational Medicine. 2: 56ra80. PMID 21048216 DOI: 10.1126/scitranslmed.3001344  1
2010 Wang S, Chandler-Militello D, Lu G, Roy NS, Zielke A, Auvergne R, Stanwood N, Geschwind D, Coppola G, Nicolis SK, Sim FJ, Goldman SA. Prospective identification, isolation, and profiling of a telomerase-expressing subpopulation of human neural stem cells, using sox2 enhancer-directed fluorescence-activated cell sorting. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 30: 14635-48. PMID 21048121 DOI: 10.1523/JNEUROSCI.1729-10.2010  1
2010 Konopka G, Geschwind DH. Human brain evolution: harnessing the genomics (r)evolution to link genes, cognition, and behavior. Neuron. 68: 231-44. PMID 20955931 DOI: 10.1016/j.neuron.2010.10.012  1
2010 Costigan M, Belfer I, Griffin RS, Dai F, Barrett LB, Coppola G, Wu T, Kiselycznyk C, Poddar M, Lu Y, Diatchenko L, Smith S, Cobos EJ, Zaykin D, Allchorne A, ... ... Geschwind DH, et al. Multiple chronic pain states are associated with a common amino acid-changing allele in KCNS1. Brain : a Journal of Neurology. 133: 2519-27. PMID 20724292 DOI: 10.1093/brain/awq195  1
2010 McConoughey SJ, Basso M, Niatsetskaya ZV, Sleiman SF, Smirnova NA, Langley BC, Mahishi L, Cooper AJ, Antonyak MA, Cerione RA, Li B, Starkov A, Chaturvedi RK, Beal MF, Coppola G, ... Geschwind DH, et al. Inhibition of transglutaminase 2 mitigates transcriptional dysregulation in models of Huntington disease. Embo Molecular Medicine. 2: 349-70. PMID 20665636 DOI: 10.1002/emmm.201000084  1
2010 Anney R, Klei L, Pinto D, Regan R, Conroy J, Magalhaes TR, Correia C, Abrahams BS, Sykes N, Pagnamenta AT, Almeida J, Bacchelli E, Bailey AJ, Baird G, Battaglia A, ... ... Geschwind DH, et al. A genome-wide scan for common alleles affecting risk for autism. Human Molecular Genetics. 19: 4072-82. PMID 20663923 DOI: 10.1093/hmg/ddq307  0.72
2010 Michaelevski I, Segal-Ruder Y, Rozenbaum M, Medzihradszky KF, Shalem O, Coppola G, Horn-Saban S, Ben-Yaakov K, Dagan SY, Rishal I, Geschwind DH, Pilpel Y, Burlingame AL, Fainzilber M. Signaling to transcription networks in the neuronal retrograde injury response. Science Signaling. 3: ra53. PMID 20628157 DOI: 10.1126/scisignal.2000952  1
2010 Miller JA, Horvath S, Geschwind DH. Divergence of human and mouse brain transcriptome highlights Alzheimer disease pathways. Proceedings of the National Academy of Sciences of the United States of America. 107: 12698-703. PMID 20616000 DOI: 10.1073/pnas.0914257107  0.68
2010 Mumford JA, Horvath S, Oldham MC, Langfelder P, Geschwind DH, Poldrack RA. Detecting network modules in fMRI time series: a weighted network analysis approach. Neuroimage. 52: 1465-76. PMID 20553896 DOI: 10.1016/j.neuroimage.2010.05.047  1
2010 Pinto D, Pagnamenta AT, Klei L, Anney R, Merico D, Regan R, Conroy J, Magalhaes TR, Correia C, Abrahams BS, Almeida J, Bacchelli E, Bader GD, Bailey AJ, Baird G, ... ... Geschwind DH, et al. Functional impact of global rare copy number variation in autism spectrum disorders. Nature. 466: 368-72. PMID 20531469 DOI: 10.1038/nature09146  0.72
2010 Panaitof SC, Abrahams BS, Dong H, Geschwind DH, White SA. Language-related Cntnap2 gene is differentially expressed in sexually dimorphic song nuclei essential for vocal learning in songbirds. The Journal of Comparative Neurology. 518: 1995-2018. PMID 20394055 DOI: 10.1002/cne.22318  1
2010 Abrahams BS, Geschwind DH. Connecting genes to brain in the autism spectrum disorders. Archives of Neurology. 67: 395-9. PMID 20385903 DOI: 10.1001/archneurol.2010.47  1
2010 Ross ME, Geschwind D. Genes and the long and winding road to cortical construction and cognition. Neurobiology of Disease. 38: 145-7. PMID 20381768 DOI: 10.1016/j.nbd.2010.03.004  1
2010 Sarafian TA, Montes C, Imura T, Qi J, Coppola G, Geschwind DH, Sofroniew MV. Disruption of astrocyte STAT3 signaling decreases mitochondrial function and increases oxidative stress in vitro. Plos One. 5: e9532. PMID 20224768 DOI: 10.1371/journal.pone.0009532  1
2010 Bartzokis G, Lu PH, Tishler TA, Peters DG, Kosenko A, Barrall KA, Finn JP, Villablanca P, Laub G, Altshuler LL, Geschwind DH, Mintz J, Neely E, Connor JR. Prevalent iron metabolism gene variants associated with increased brain ferritin iron in healthy older men. Journal of Alzheimer's Disease : Jad. 20: 333-41. PMID 20164577 DOI: 10.3233/JAD-2010-1368  1
2010 Shoemaker LD, Orozco NM, Geschwind DH, Whitelegge JP, Faull KF, Kornblum HI. Identification of differentially expressed proteins in murine embryonic and postnatal cortical neural progenitors. Plos One. 5: e9121. PMID 20161753 DOI: 10.1371/journal.pone.0009121  1
2010 Hilton CL, Fitzgerald RT, Jackson KM, Maxim RA, Bosworth CC, Shattuck PT, Geschwind DH, Constantino JN. Brief report: Under-representation of African americans in autism genetic research: a rationale for inclusion of subjects representing diverse family structures. Journal of Autism and Developmental Disorders. 40: 633-9. PMID 19936905 DOI: 10.1007/s10803-009-0905-2  1
2010 Ziegler L, Segal-Ruder Y, Coppola G, Reis A, Geschwind D, Fainzilber M, Goldstein RS. A human neuron injury model for molecular studies of axonal regeneration. Experimental Neurology. 223: 119-27. PMID 19804775 DOI: 10.1016/j.expneurol.2009.09.019  1
2010 Strom SP, Stone JL, Ten Bosch JR, Merriman B, Cantor RM, Geschwind DH, Nelson SF. High-density SNP association study of the 17q21 chromosomal region linked to autism identifies CACNA1G as a novel candidate gene. Molecular Psychiatry. 15: 996-1005. PMID 19455149 DOI: 10.1038/mp.2009.41  0.44
2009 Konopka G, Bomar JM, Winden K, Coppola G, Jonsson ZO, Gao F, Peng S, Preuss TM, Wohlschlegel JA, Geschwind DH. Human-specific transcriptional regulation of CNS development genes by FOXP2. Nature. 462: 213-7. PMID 19907493 DOI: 10.1038/nature08549  1
2009 Kadoya K, Tsukada S, Lu P, Coppola G, Geschwind D, Filbin MT, Blesch A, Tuszynski MH. Combined intrinsic and extrinsic neuronal mechanisms facilitate bridging axonal regeneration one year after spinal cord injury. Neuron. 64: 165-72. PMID 19874785 DOI: 10.1016/j.neuron.2009.09.016  1
2009 Geschwind DH, Konopka G. Neuroscience in the era of functional genomics and systems biology. Nature. 461: 908-15. PMID 19829370 DOI: 10.1038/nature08537  1
2009 Winden KD, Oldham MC, Mirnics K, Ebert PJ, Swan CH, Levitt P, Rubenstein JL, Horvath S, Geschwind DH. The organization of the transcriptional network in specific neuronal classes. Molecular Systems Biology. 5: 291. PMID 19638972 DOI: 10.1038/msb.2009.46  1
2009 Bucan M, Abrahams BS, Wang K, Glessner JT, Herman EI, Sonnenblick LI, Alvarez Retuerto AI, Imielinski M, Hadley D, Bradfield JP, Kim C, Gidaya NB, Lindquist I, Hutman T, Sigman M, ... ... Geschwind DH, et al. Genome-wide analyses of exonic copy number variants in a family-based study point to novel autism susceptibility genes. Plos Genetics. 5: e1000536. PMID 19557195 DOI: 10.1371/journal.pgen.1000536  1
2009 Zai L, Ferrari C, Subbaiah S, Havton LA, Coppola G, Strittmatter S, Irwin N, Geschwind D, Benowitz LI. Inosine alters gene expression and axonal projections in neurons contralateral to a cortical infarct and improves skilled use of the impaired limb. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 29: 8187-97. PMID 19553458 DOI: 10.1523/JNEUROSCI.0414-09.2009  1
2009 Pappas DJ, Coppola G, Gabatto PA, Gao F, Geschwind DH, Oksenberg JR, Baranzini SE. Longitudinal system-based analysis of transcriptional responses to type I interferons. Physiological Genomics. 38: 362-71. PMID 19531577 DOI: 10.1152/physiolgenomics.00058.2009  0.36
2009 Bill BR, Geschwind DH. Genetic advances in autism: heterogeneity and convergence on shared pathways. Current Opinion in Genetics & Development. 19: 271-8. PMID 19477629 DOI: 10.1016/j.gde.2009.04.004  1
2009 Johnson MB, Kawasawa YI, Mason CE, Krsnik Z, Coppola G, Bogdanovi? D, Geschwind DH, Mane SM, State MW, Sestan N. Functional and evolutionary insights into human brain development through global transcriptome analysis. Neuron. 62: 494-509. PMID 19477152 DOI: 10.1016/j.neuron.2009.03.027  1
2009 Woods DL, Bushnell B, Kim H, Geschwind D, Cummings J. Apolipoprotein epsilon4 status is associated with behavioral symptoms in nursing home residents with dementia. International Psychogeriatrics / Ipa. 21: 722-8. PMID 19470200 DOI: 10.1017/S1041610209009235  1
2009 Wexler EM, Paucer A, Kornblum HI, Palmer TD, Plamer TD, Geschwind DH. Endogenous Wnt signaling maintains neural progenitor cell potency. Stem Cells (Dayton, Ohio). 27: 1130-41. PMID 19418460 DOI: 10.1002/stem.36  1
2009 Wang K, Zhang H, Ma D, Bucan M, Glessner JT, Abrahams BS, Salyakina D, Imielinski M, Bradfield JP, Sleiman PM, Kim CE, Hou C, Frackelton E, Chiavacci R, Takahashi N, ... ... Geschwind DH, et al. Common genetic variants on 5p14.1 associate with autism spectrum disorders. Nature. 459: 528-33. PMID 19404256 DOI: 10.1038/nature07999  1
2009 Coppola G, Marmolino D, Lu D, Wang Q, Cnop M, Rai M, Acquaviva F, Cocozza S, Pandolfo M, Geschwind DH. Functional genomic analysis of frataxin deficiency reveals tissue-specific alterations and identifies the PPARgamma pathway as a therapeutic target in Friedreich's ataxia. Human Molecular Genetics. 18: 2452-61. PMID 19376812 DOI: 10.1093/hmg/ddp183  0.4
2009 Criscuolo C, Filla A, Coppola G, Rinaldi C, Carbone R, Pinto S, Wang Q, de Leva MF, Salvatore E, Banfi S, Brunetti A, Quarantelli M, Geschwind DH, Pappatà S, De Michele G. Two novel CYP7B1 mutations in Italian families with SPG5: a clinical and genetic study. Journal of Neurology. 256: 1252-7. PMID 19363635 DOI: 10.1007/s00415-009-5109-3  1
2009 Bajpai R, Coppola G, Kaul M, Talantova M, Cimadamore F, Nilbratt M, Geschwind DH, Lipton SA, Terskikh AV. Molecular stages of rapid and uniform neuralization of human embryonic stem cells. Cell Death and Differentiation. 16: 807-25. PMID 19282867 DOI: 10.1038/cdd.2009.18  1
2009 Marques F, Sousa JC, Coppola G, Falcao AM, Rodrigues AJ, Geschwind DH, Sousa N, Correia-Neves M, Palha JA. Kinetic profile of the transcriptome changes induced in the choroid plexus by peripheral inflammation. Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism. 29: 921-32. PMID 19240744 DOI: 10.1038/jcbfm.2009.15  1
2009 Marques F, Falcao AM, Sousa JC, Coppola G, Geschwind D, Sousa N, Correia-Neves M, Palha JA. Altered iron metabolism is part of the choroid plexus response to peripheral inflammation. Endocrinology. 150: 2822-8. PMID 19213835 DOI: 10.1210/en.2008-1610  1
2009 Nagahara AH, Merrill DA, Coppola G, Tsukada S, Schroeder BE, Shaked GM, Wang L, Blesch A, Kim A, Conner JM, Rockenstein E, Chao MV, Koo EH, Geschwind D, Masliah E, et al. Neuroprotective effects of brain-derived neurotrophic factor in rodent and primate models of Alzheimer's disease. Nature Medicine. 15: 331-7. PMID 19198615 DOI: 10.1038/nm.1912  1
2009 Kelly TK, Karsten SL, Geschwind DH, Kornblum HI. Cell lineage and regional identity of cultured spinal cord neural stem cells and comparison to brain-derived neural stem cells. Plos One. 4: e4213. PMID 19148290 DOI: 10.1371/journal.pone.0004213  1
2008 Ratan RR, Siddiq A, Aminova L, Langley B, McConoughey S, Karpisheva K, Lee HH, Carmichael T, Kornblum H, Coppola G, Geschwind DH, Hoke A, Smirnova N, Rink C, Roy S, et al. Small molecule activation of adaptive gene expression: tilorone or its analogs are novel potent activators of hypoxia inducible factor-1 that provide prophylaxis against stroke and spinal cord injury. Annals of the New York Academy of Sciences. 1147: 383-94. PMID 19076458 DOI: 10.1196/annals.1427.033  1
2008 Vernes SC, Newbury DF, Abrahams BS, Winchester L, Nicod J, Groszer M, Alarcón M, Oliver PL, Davies KE, Geschwind DH, Monaco AP, Fisher SE. A functional genetic link between distinct developmental language disorders. The New England Journal of Medicine. 359: 2337-45. PMID 18987363 DOI: 10.1056/NEJMoa0802828  1
2008 Karsten SL, Kudo LC, Geschwind DH. Gene expression analysis of neural cells and tissues using DNA microarrays. Current Protocols in Neuroscience / Editorial Board, Jacqueline N. Crawley ... [Et Al.]. Unit 4.28. PMID 18972379 DOI: 10.1002/0471142301.ns0428s45  1
2008 Schaffer BA, Bertram L, Miller BL, Mullin K, Weintraub S, Johnson N, Bigio EH, Mesulam M, Wiedau-Pazos M, Jackson GR, Cummings JL, Cantor RM, Levey AI, Tanzi RE, Geschwind DH. Association of GSK3B with Alzheimer disease and frontotemporal dementia. Archives of Neurology. 65: 1368-74. PMID 18852354 DOI: 10.1001/archneur.65.10.1368  1
2008 Oldham MC, Konopka G, Iwamoto K, Langfelder P, Kato T, Horvath S, Geschwind DH. Functional organization of the transcriptome in human brain. Nature Neuroscience. 11: 1271-82. PMID 18849986 DOI: 10.1038/nn.2207  1
2008 Thomas EA, Coppola G, Desplats PA, Tang B, Soragni E, Burnett R, Gao F, Fitzgerald KM, Borok JF, Herman D, Geschwind DH, Gottesfeld JM. The HDAC inhibitor 4b ameliorates the disease phenotype and transcriptional abnormalities in Huntington's disease transgenic mice. Proceedings of the National Academy of Sciences of the United States of America. 105: 15564-9. PMID 18829438 DOI: 10.1073/pnas.0804249105  1
2008 Rutherford NJ, Zhang YJ, Baker M, Gass JM, Finch NA, Xu YF, Stewart H, Kelley BJ, Kuntz K, Crook RJ, Sreedharan J, Vance C, Sorenson E, Lippa C, Bigio EH, ... Geschwind DH, et al. Novel mutations in TARDBP (TDP-43) in patients with familial amyotrophic lateral sclerosis. Plos Genetics. 4: e1000193. PMID 18802454 DOI: 10.1371/journal.pgen.1000193  1
2008 Alvarez Retuerto AI, Cantor RM, Gleeson JG, Ustaszewska A, Schackwitz WS, Pennacchio LA, Geschwind DH. Association of common variants in the Joubert syndrome gene (AHI1) with autism. Human Molecular Genetics. 17: 3887-96. PMID 18782849 DOI: 10.1093/hmg/ddn291  1
2008 Miller JE, Spiteri E, Condro MC, Dosumu-Johnson RT, Geschwind DH, White SA. Birdsong decreases protein levels of FoxP2, a molecule required for human speech. Journal of Neurophysiology. 100: 2015-25. PMID 18701760 DOI: 10.1152/jn.90415.2008  1
2008 Carmichael ST, Vespa PM, Saver JL, Coppola G, Geschwind DH, Starkman S, Miller CM, Kidwell CS, Liebeskind DS, Martin NA. Genomic profiles of damage and protection in human intracerebral hemorrhage. Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism. 28: 1860-75. PMID 18628781 DOI: 10.1038/jcbfm.2008.77  1
2008 Abu-Elneel K, Liu T, Gazzaniga FS, Nishimura Y, Wall DP, Geschwind DH, Lao K, Kosik KS. Heterogeneous dysregulation of microRNAs across the autism spectrum. Neurogenetics. 9: 153-61. PMID 18563458 DOI: 10.1007/s10048-008-0133-5  1
2008 Coppola G, Karydas A, Rademakers R, Wang Q, Baker M, Hutton M, Miller BL, Geschwind DH. Gene expression study on peripheral blood identifies progranulin mutations. Annals of Neurology. 64: 92-6. PMID 18551524 DOI: 10.1002/ana.21397  1
2008 Ringman JM, Younkin SG, Pratico D, Seltzer W, Cole GM, Geschwind DH, Rodriguez-Agudelo Y, Schaffer B, Fein J, Sokolow S, Rosario ER, Gylys KH, Varpetian A, Medina LD, Cummings JL. Biochemical markers in persons with preclinical familial Alzheimer disease. Neurology. 71: 85-92. PMID 18509095 DOI: 10.1212/01.wnl.0000303973.71803.81  1
2008 Rosen RF, Farberg AS, Gearing M, Dooyema J, Long PM, Anderson DC, Davis-Turak J, Coppola G, Geschwind DH, Paré JF, Duong TQ, Hopkins WD, Preuss TM, Walker LC. Tauopathy with paired helical filaments in an aged chimpanzee. The Journal of Comparative Neurology. 509: 259-70. PMID 18481275 DOI: 10.1002/cne.21744  1
2008 Dibbens LM, Tarpey PS, Hynes K, Bayly MA, Scheffer IE, Smith R, Bomar J, Sutton E, Vandeleur L, Shoubridge C, Edkins S, Turner SJ, Stevens C, O'Meara S, Tofts C, ... ... Geschwind DH, et al. X-linked protocadherin 19 mutations cause female-limited epilepsy and cognitive impairment. Nature Genetics. 40: 776-81. PMID 18469813 DOI: 10.1038/ng.149  1
2008 Rai M, Soragni E, Jenssen K, Burnett R, Herman D, Coppola G, Geschwind DH, Gottesfeld JM, Pandolfo M. HDAC inhibitors correct frataxin deficiency in a Friedreich ataxia mouse model. Plos One. 3: e1958. PMID 18463734 DOI: 10.1371/journal.pone.0001958  1
2008 Lange PS, Chavez JC, Pinto JT, Coppola G, Sun CW, Townes TM, Geschwind DH, Ratan RR. ATF4 is an oxidative stress-inducible, prodeath transcription factor in neurons in vitro and in vivo. The Journal of Experimental Medicine. 205: 1227-42. PMID 18458112 DOI: 10.1084/jem.20071460  1
2008 Cantor RM, Geschwind DH. Schizophrenia: genome, interrupted. Neuron. 58: 165-7. PMID 18439401 DOI: 10.1016/j.neuron.2008.04.007  0.44
2008 Abrahams BS, Geschwind DH. Advances in autism genetics: on the threshold of a new neurobiology. Nature Reviews. Genetics. 9: 341-55. PMID 18414403 DOI: 10.1038/nrg2346  1
2008 Krystal JH, Carter CS, Geschwind D, Manji HK, March JS, Nestler EJ, Zubieta JK, Charney DS, Goldman D, Gur RE, Lieberman JA, Roy-Byrne P, Rubinow DR, Anderson SA, Barondes S, et al. It is time to take a stand for medical research and against terrorism targeting medical scientists. Biological Psychiatry. 63: 725-7. PMID 18371494 DOI: 10.1016/j.biopsych.2008.03.005  1
2008 Miller JA, Oldham MC, Geschwind DH. A systems level analysis of transcriptional changes in Alzheimer's disease and normal aging. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 28: 1410-20. PMID 18256261 DOI: 10.1523/JNEUROSCI.4098-07.2008  0.68
2008 Bakkaloglu B, O'Roak BJ, Louvi A, Gupta AR, Abelson JF, Morgan TM, Chawarska K, Klin A, Ercan-Sencicek AG, Stillman AA, Tanriover G, Abrahams BS, Duvall JA, Robbins EM, Geschwind DH, et al. Molecular cytogenetic analysis and resequencing of contactin associated protein-like 2 in autism spectrum disorders. American Journal of Human Genetics. 82: 165-73. PMID 18179895 DOI: 10.1016/j.ajhg.2007.09.017  1
2008 Alarcón M, Abrahams BS, Stone JL, Duvall JA, Perederiy JV, Bomar JM, Sebat J, Wigler M, Martin CL, Ledbetter DH, Nelson SF, Cantor RM, Geschwind DH. Linkage, association, and gene-expression analyses identify CNTNAP2 as an autism-susceptibility gene. American Journal of Human Genetics. 82: 150-9. PMID 18179893 DOI: 10.1016/j.ajhg.2007.09.005  1
2008 Wexler EM, Geschwind DH, Palmer TD. Lithium regulates adult hippocampal progenitor development through canonical Wnt pathway activation. Molecular Psychiatry. 13: 285-92. PMID 17968353 DOI: 10.1038/sj.mp.4002093  1
2008 Marques F, Rodrigues AJ, Sousa JC, Coppola G, Geschwind DH, Sousa N, Correia-Neves M, Palha JA. Lipocalin 2 is a choroid plexus acute-phase protein. Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism. 28: 450-5. PMID 17895910 DOI: 10.1038/sj.jcbfm.9600557  1
2008 Nakano I, Masterman-Smith M, Saigusa K, Paucar AA, Horvath S, Shoemaker L, Watanabe M, Negro A, Bajpai R, Howes A, Lelievre V, Waschek JA, Lazareff JA, Freije WA, Liau LM, ... ... Geschwind DH, et al. Maternal embryonic leucine zipper kinase is a key regulator of the proliferation of malignant brain tumors, including brain tumor stem cells. Journal of Neuroscience Research. 86: 48-60. PMID 17722061 DOI: 10.1002/jnr.21471  1
2007 Wexler EM, Geschwind DH. Out FOXing Parkinson disease: where development meets neurodegeneration. Plos Biology. 5: e334. PMID 18092892 DOI: 10.1371/journal.pbio.0050334  1
2007 Vernes SC, Spiteri E, Nicod J, Groszer M, Taylor JM, Davies KE, Geschwind DH, Fisher SE. High-throughput analysis of promoter occupancy reveals direct neural targets of FOXP2, a gene mutated in speech and language disorders. American Journal of Human Genetics. 81: 1232-50. PMID 17999362 DOI: 10.1086/522238  1
2007 Spiteri E, Konopka G, Coppola G, Bomar J, Oldham M, Ou J, Vernes SC, Fisher SE, Ren B, Geschwind DH. Identification of the transcriptional targets of FOXP2, a gene linked to speech and language, in developing human brain. American Journal of Human Genetics. 81: 1144-57. PMID 17999357 DOI: 10.1086/522237  1
2007 Abrahams BS, Tentler D, Perederiy JV, Oldham MC, Coppola G, Geschwind DH. Genome-wide analyses of human perisylvian cerebral cortical patterning. Proceedings of the National Academy of Sciences of the United States of America. 104: 17849-54. PMID 17978184 DOI: 10.1073/pnas.0706128104  1
2007 Rademakers R, Baker M, Gass J, Adamson J, Huey ED, Momeni P, Spina S, Coppola G, Karydas AM, Stewart H, Johnson N, Hsiung GY, Kelley B, Kuntz K, Steinbart E, ... ... Geschwind DH, et al. Phenotypic variability associated with progranulin haploinsufficiency in patients with the common 1477C-->T (Arg493X) mutation: an international initiative. The Lancet. Neurology. 6: 857-68. PMID 17826340 DOI: 10.1016/S1474-4422(07)70221-1  1
2007 Francks C, Maegawa S, Laurén J, Abrahams BS, Velayos-Baeza A, Medland SE, Colella S, Groszer M, McAuley EZ, Caffrey TM, Timmusk T, Pruunsild P, Koppel I, Lind PA, Matsumoto-Itaba N, ... ... Geschwind DH, et al. LRRTM1 on chromosome 2p12 is a maternally suppressed gene that is associated paternally with handedness and schizophrenia. Molecular Psychiatry. 12: 1129-39, 1057. PMID 17667961 DOI: 10.1038/sj.mp.4002053  1
2007 Zhao X, Leotta A, Kustanovich V, Lajonchere C, Geschwind DH, Law K, Law P, Qiu S, Lord C, Sebat J, Ye K, Wigler M. A unified genetic theory for sporadic and inherited autism. Proceedings of the National Academy of Sciences of the United States of America. 104: 12831-6. PMID 17652511 DOI: 10.1073/pnas.0705803104  1
2007 Ringman JM, O'Neill J, Geschwind D, Medina L, Apostolova LG, Rodriguez Y, Schaffer B, Varpetian A, Tseng B, Ortiz F, Fitten J, Cummings JL, Bartzokis G. Diffusion tensor imaging in preclinical and presymptomatic carriers of familial Alzheimer's disease mutations. Brain : a Journal of Neurology. 130: 1767-76. PMID 17522104 DOI: 10.1093/brain/awm102  1
2007 Nishimura Y, Martin CL, Vazquez-Lopez A, Spence SJ, Alvarez-Retuerto AI, Sigman M, Steindler C, Pellegrini S, Schanen NC, Warren ST, Geschwind DH. Genome-wide expression profiling of lymphoblastoid cell lines distinguishes different forms of autism and reveals shared pathways. Human Molecular Genetics. 16: 1682-98. PMID 17519220 DOI: 10.1093/hmg/ddm116  1
2007 Martin CL, Duvall JA, Ilkin Y, Simon JS, Arreaza MG, Wilkes K, Alvarez-Retuerto A, Whichello A, Powell CM, Rao K, Cook E, Geschwind DH. Cytogenetic and molecular characterization of A2BP1/FOX1 as a candidate gene for autism. American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics. 144: 869-76. PMID 17503474 DOI: 10.1002/ajmg.b.30530  1
2007 Nakano I, Dougherty JD, Kim K, Klement I, Geschwind DH, Kornblum HI. Phosphoserine phosphatase is expressed in the neural stem cell niche and regulates neural stem and progenitor cell proliferation. Stem Cells (Dayton, Ohio). 25: 1975-84. PMID 17495110 DOI: 10.1634/stemcells.2007-0046  1
2007 Duvall JA, Lu A, Cantor RM, Todd RD, Constantino JN, Geschwind DH. A quantitative trait locus analysis of social responsiveness in multiplex autism families. The American Journal of Psychiatry. 164: 656-62. PMID 17403980 DOI: 10.1176/appi.ajp.164.4.656  1
2007 Stone JL, Merriman B, Cantor RM, Geschwind DH, Nelson SF. High density SNP association study of a major autism linkage region on chromosome 17. Human Molecular Genetics. 16: 704-15. PMID 17376794 DOI: 10.1093/hmg/ddm015  0.44
2007 Sebat J, Lakshmi B, Malhotra D, Troge J, Lese-Martin C, Walsh T, Yamrom B, Yoon S, Krasnitz A, Kendall J, Leotta A, Pai D, Zhang R, Lee YH, Hicks J, ... ... Geschwind DH, et al. Strong association of de novo copy number mutations with autism. Science (New York, N.Y.). 316: 445-9. PMID 17363630 DOI: 10.1126/science.1138659  1
2007 Szatmari P, Paterson AD, Zwaigenbaum L, Roberts W, Brian J, Liu XQ, Vincent JB, Skaug JL, Thompson AP, Senman L, Feuk L, Qian C, Bryson SE, Jones MB, ... ... Geschwind DH, et al. Mapping autism risk loci using genetic linkage and chromosomal rearrangements. Nature Genetics. 39: 319-28. PMID 17322880 DOI: 10.1038/ng1985  1
2007 Geschwind DH, Levitt P. Autism spectrum disorders: developmental disconnection syndromes. Current Opinion in Neurobiology. 17: 103-11. PMID 17275283 DOI: 10.1016/j.conb.2007.01.009  1
2007 Kudo LC, Karsten SL, Chen J, Levitt P, Geschwind DH. Genetic analysis of anterior posterior expression gradients in the developing mammalian forebrain. Cerebral Cortex (New York, N.Y. : 1991). 17: 2108-22. PMID 17150988 DOI: 10.1093/cercor/bhl118  1
2006 Poon MM, Choi SH, Jamieson CA, Geschwind DH, Martin KC. Identification of process-localized mRNAs from cultured rodent hippocampal neurons. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 26: 13390-9. PMID 17182790 DOI: 10.1523/JNEUROSCI.3432-06.2006  1
2006 Sengupta S, Horowitz PM, Karsten SL, Jackson GR, Geschwind DH, Fu Y, Berry RW, Binder LI. Degradation of tau protein by puromycin-sensitive aminopeptidase in vitro. Biochemistry. 45: 15111-9. PMID 17154549 DOI: 10.1021/bi061830d  1
2006 Oldham MC, Horvath S, Geschwind DH. Conservation and evolution of gene coexpression networks in human and chimpanzee brains. Proceedings of the National Academy of Sciences of the United States of America. 103: 17973-8. PMID 17101986 DOI: 10.1073/pnas.0605938103  0.68
2006 Horvath S, Zhang B, Carlson M, Lu KV, Zhu S, Felciano RM, Laurance MF, Zhao W, Qi S, Chen Z, Lee Y, Scheck AC, Liau LM, Wu H, Geschwind DH, et al. Analysis of oncogenic signaling networks in glioblastoma identifies ASPM as a molecular target. Proceedings of the National Academy of Sciences of the United States of America. 103: 17402-7. PMID 17090670 DOI: 10.1073/pnas.0608396103  1
2006 White SA, Fisher SE, Geschwind DH, Scharff C, Holy TE. Singing mice, songbirds, and more: models for FOXP2 function and dysfunction in human speech and language. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 26: 10376-9. PMID 17035521 DOI: 10.1523/JNEUROSCI.3379-06.2006  1
2006 Karsten SL, Sang TK, Gehman LT, Chatterjee S, Liu J, Lawless GM, Sengupta S, Berry RW, Pomakian J, Oh HS, Schulz C, Hui KS, Wiedau-Pazos M, Vinters HV, Binder LI, ... Geschwind DH, et al. A genomic screen for modifiers of tauopathy identifies puromycin-sensitive aminopeptidase as an inhibitor of tau-induced neurodegeneration. Neuron. 51: 549-60. PMID 16950154 DOI: 10.1016/j.neuron.2006.07.019  1
2006 Coppola G, Geschwind DH. Technology Insight: querying the genome with microarrays--progress and hope for neurological disease. Nature Clinical Practice. Neurology. 2: 147-58. PMID 16932541 DOI: 10.1038/ncpneuro0133  1
2006 Coppola G, Geschwind DH. Microarrays and the microscope: balancing throughput with resolution. The Journal of Physiology. 575: 353-9. PMID 16809370 DOI: 10.1113/jphysiol.2006.112623  1
2006 Spence SJ, Cantor RM, Chung L, Kim S, Geschwind DH, Alarcón M. Stratification based on language-related endophenotypes in autism: attempt to replicate reported linkage. American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics. 141: 591-8. PMID 16752361 DOI: 10.1002/ajmg.b.30329  1
2006 Oldham MC, Geschwind DH. Comparative genomics: grasping human transcriptome evolution: what does it all mean? Heredity. 96: 339-40. PMID 16552432 DOI: 10.1038/sj.hdy.6800807  0.68
2006 Lobo MK, Karsten SL, Gray M, Geschwind DH, Yang XW. FACS-array profiling of striatal projection neuron subtypes in juvenile and adult mouse brains. Nature Neuroscience. 9: 443-52. PMID 16491081 DOI: 10.1038/nn1654  1
2006 Coppola G, Choi SH, Santos MM, Miranda CJ, Tentler D, Wexler EM, Pandolfo M, Geschwind DH. Gene expression profiling in frataxin deficient mice: microarray evidence for significant expression changes without detectable neurodegeneration. Neurobiology of Disease. 22: 302-11. PMID 16442805 DOI: 10.1016/j.nbd.2005.11.014  1
2006 Oldham MC, Geschwind DH. Deconstructing language by comparative gene expression: from neurobiology to microarray. Genes, Brain, and Behavior. 5: 54-63. PMID 16417618 DOI: 10.1111/j.1601-183X.2006.00195.x  0.68
2006 Groszer M, Erickson R, Scripture-Adams DD, Dougherty JD, Le Belle J, Zack JA, Geschwind DH, Liu X, Kornblum HI, Wu H. PTEN negatively regulates neural stem cell self-renewal by modulating G0-G1 cell cycle entry. Proceedings of the National Academy of Sciences of the United States of America. 103: 111-6. PMID 16373498 DOI: 10.1073/pnas.0509939103  1
2006 Ylisaukko-oja T, Alarcón M, Cantor RM, Auranen M, Vanhala R, Kempas E, von Wendt L, Järvelä I, Geschwind DH, Peltonen L. Search for autism loci by combined analysis of Autism Genetic Resource Exchange and Finnish families. Annals of Neurology. 59: 145-55. PMID 16288458 DOI: 10.1002/ana.20722  0.44
2006 Chen GK, Kono N, Geschwind DH, Cantor RM. Quantitative trait locus analysis of nonverbal communication in autism spectrum disorder. Molecular Psychiatry. 11: 214-20. PMID 16189504 DOI: 10.1038/sj.mp.4001753  1
2005 Bhidayasiri R, Perlman SL, Pulst SM, Geschwind DH. Late-onset Friedreich ataxia: phenotypic analysis, magnetic resonance imaging findings, and review of the literature. Archives of Neurology. 62: 1865-9. PMID 16344344 DOI: 10.1001/archneur.62.12.1865  1
2005 Dougherty JD, Garcia AD, Nakano I, Livingstone M, Norris B, Polakiewicz R, Wexler EM, Sofroniew MV, Kornblum HI, Geschwind DH. PBK/TOPK, a proliferating neural progenitor-specific mitogen-activated protein kinase kinase. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 25: 10773-85. PMID 16291951 DOI: 10.1523/JNEUROSCI.3207-05.2005  1
2005 Nakano I, Paucar AA, Bajpai R, Dougherty JD, Zewail A, Kelly TK, Kim KJ, Ou J, Groszer M, Imura T, Freije WA, Nelson SF, Sofroniew MV, Wu H, Liu X, ... ... Geschwind DH, et al. Maternal embryonic leucine zipper kinase (MELK) regulates multipotent neural progenitor proliferation. The Journal of Cell Biology. 170: 413-27. PMID 16061694 DOI: 10.1083/jcb.200412115  1
2005 Sun T, Patoine C, Abu-Khalil A, Visvader J, Sum E, Cherry TJ, Orkin SH, Geschwind DH, Walsh CA. Early asymmetry of gene transcription in embryonic human left and right cerebral cortex. Science (New York, N.Y.). 308: 1794-8. PMID 15894532 DOI: 10.1126/science.1110324  1
2005 Cantor RM, Kono N, Duvall JA, Alvarez-Retuerto A, Stone JL, Alarcón M, Nelson SF, Geschwind DH. Replication of autism linkage: fine-mapping peak at 17q21. American Journal of Human Genetics. 76: 1050-6. PMID 15877280 DOI: 10.1086/430278  1
2005 Alarcón M, Yonan AL, Gilliam TC, Cantor RM, Geschwind DH. Quantitative genome scan and Ordered-Subsets Analysis of autism endophenotypes support language QTLs. Molecular Psychiatry. 10: 747-57. PMID 15824743 DOI: 10.1038/sj.mp.4001666  1
2005 Karsten SL, Geschwind DH. Exercise your amyloid. Cell. 120: 572-4. PMID 15766520 DOI: 10.1016/j.cell.2005.02.027  1
2005 Oldham MC, Geschwind DH. Evolutionary genetics: the human brain -- adaptation at many levels. European Journal of Human Genetics : Ejhg. 13: 520-2. PMID 15756295 DOI: 10.1038/sj.ejhg.5201401  0.68
2005 Dougherty JD, Geschwind DH. Progress in realizing the promise of microarrays in systems neurobiology. Neuron. 45: 183-5. PMID 15664168 DOI: 10.1016/j.neuron.2005.01.007  1
2004 Oliveira JR, Spiteri E, Sobrido MJ, Hopfer S, Klepper J, Voit T, Gilbert J, Wszolek ZK, Calne DB, Stoessl AJ, Hutton M, Manyam BV, Boller F, Baquero M, Geschwind DH. Genetic heterogeneity in familial idiopathic basal ganglia calcification (Fahr disease). Neurology. 63: 2165-7. PMID 15596772  1
2004 Preuss TM, Cáceres M, Oldham MC, Geschwind DH. Human brain evolution: insights from microarrays. Nature Reviews. Genetics. 5: 850-60. PMID 15520794 DOI: 10.1038/nrg1469  1
2004 Karsten SL, Kudo LC, Geschwind DH. Microarray platforms: introduction and application to neurobiology. International Review of Neurobiology. 60: 1-23. PMID 15474585 DOI: 10.1016/S0074-7742(04)60001-8  1
2004 Stone JL, Merriman B, Cantor RM, Yonan AL, Gilliam TC, Geschwind DH, Nelson SF. Evidence for sex-specific risk alleles in autism spectrum disorder. American Journal of Human Genetics. 75: 1117-23. PMID 15467983 DOI: 10.1086/426034  0.44
2004 Abu-Khalil A, Fu L, Grove EA, Zecevic N, Geschwind DH. Wnt genes define distinct boundaries in the developing human brain: implications for human forebrain patterning. The Journal of Comparative Neurology. 474: 276-88. PMID 15164427 DOI: 10.1002/cne.20112  1
2004 Jen JC, Chan WM, Bosley TM, Wan J, Carr JR, Rüb U, Shattuck D, Salamon G, Kudo LC, Ou J, Lin DD, Salih MA, Kansu T, Al Dhalaan H, Al Zayed Z, ... ... Geschwind DH, et al. Mutations in a human ROBO gene disrupt hindbrain axon pathway crossing and morphogenesis. Science (New York, N.Y.). 304: 1509-13. PMID 15105459 DOI: 10.1126/science.1096437  1
2004 Teramitsu I, Kudo LC, London SE, Geschwind DH, White SA. Parallel FoxP1 and FoxP2 expression in songbird and human brain predicts functional interaction. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 24: 3152-63. PMID 15056695 DOI: 10.1523/JNEUROSCI.5589-03.2004  1
2004 Bragin A, Karsten SL, Almajano J, Wilson CL, Geschwind DH, Engel J. Large-scale microarray gene expression analysis in discrete electrophysiologically identified neuronal clusters. Journal of Neuroscience Methods. 133: 49-55. PMID 14757344 DOI: 10.1016/j.jneumeth.2003.09.016  1
2004 Hedlund E, Karsten SL, Kudo L, Geschwind DH, Carpenter EM. Identification of a Hoxd10-regulated transcriptional network and combinatorial interactions with Hoxa10 during spinal cord development. Journal of Neuroscience Research. 75: 307-19. PMID 14743444 DOI: 10.1002/jnr.10844  1
2003 Easterday MC, Dougherty JD, Jackson RL, Ou J, Nakano I, Paucar AA, Roobini B, Dianati M, Irvin DK, Weissman IL, Terskikh AV, Geschwind DH, Kornblum HI. Neural progenitor genes. Germinal zone expression and analysis of genetic overlap in stem cell populations. Developmental Biology. 264: 309-22. PMID 14651920 DOI: 10.1016/j.ydbio.2003.09.003  1
2003 Hemmati HD, Nakano I, Lazareff JA, Masterman-Smith M, Geschwind DH, Bronner-Fraser M, Kornblum HI. Cancerous stem cells can arise from pediatric brain tumors. Proceedings of the National Academy of Sciences of the United States of America. 100: 15178-83. PMID 14645703 DOI: 10.1073/pnas.2036535100  1
2003 Fales CL, Knowlton BJ, Holyoak KJ, Geschwind DH, Swerdloff RS, Gonzalo IG. Working memory and relational reasoning in Klinefelter syndrome. Journal of the International Neuropsychological Society : Jins. 9: 839-46. PMID 14632242 DOI: 10.1017/S1355617703960036  1
2003 Simpson JL, de la Cruz F, Swerdloff RS, Samango-Sprouse C, Skakkebaek NE, Graham JM, Hassold T, Aylstock M, Meyer-Bahlburg HF, Willard HF, Hall JG, Salameh W, Boone K, Staessen C, Geschwind D, et al. Klinefelter syndrome: expanding the phenotype and identifying new research directions. Genetics in Medicine : Official Journal of the American College of Medical Genetics. 5: 460-8. PMID 14614399 DOI: 10.1097/01.GIM.0000095626.54201.D0  1
2003 Itti E, Gaw Gonzalo IT, Boone KB, Geschwind DH, Berman N, Pawlikowska-Haddal A, Itti L, Mishkin FS, Swerdloff RS. Functional neuroimaging provides evidence of anomalous cerebral laterality in adults with Klinefelter's syndrome. Annals of Neurology. 54: 669-73. PMID 14595657 DOI: 10.1002/ana.10735  1
2003 Cáceres M, Lachuer J, Zapala MA, Redmond JC, Kudo L, Geschwind DH, Lockhart DJ, Preuss TM, Barlow C. Elevated gene expression levels distinguish human from non-human primate brains. Proceedings of the National Academy of Sciences of the United States of America. 100: 13030-5. PMID 14557539 DOI: 10.1073/pnas.2135499100  1
2003 Yonan AL, Alarcón M, Cheng R, Magnusson PK, Spence SJ, Palmer AA, Grunn A, Juo SH, Terwilliger JD, Liu J, Cantor RM, Geschwind DH, Gilliam TC. A genomewide screen of 345 families for autism-susceptibility loci. American Journal of Human Genetics. 73: 886-97. PMID 13680528 DOI: 10.1086/378778  1
2003 Karsten SL, Kudo LC, Jackson R, Sabatti C, Kornblum HI, Geschwind DH. Global analysis of gene expression in neural progenitors reveals specific cell-cycle, signaling, and metabolic networks. Developmental Biology. 261: 165-82. PMID 12941627 DOI: 10.1016/S0012-1606(03)00274-4  1
2003 Fu L, Abu-Khalil A, Morrison RS, Geschwind DH, Kornblum HI. Expression patterns of epidermal growth factor receptor and fibroblast growth factor receptor 1 mRNA in fetal human brain. The Journal of Comparative Neurology. 462: 265-73. PMID 12794748 DOI: 10.1002/cne.10727  1
2003 Sobrido MJ, Miller BL, Havlioglu N, Zhukareva V, Jiang Z, Nasreddine ZS, Lee VM, Chow TW, Wilhelmsen KC, Cummings JL, Wu JY, Geschwind DH. Novel tau polymorphisms, tau haplotypes, and splicing in familial and sporadic frontotemporal dementia. Archives of Neurology. 60: 698-702. PMID 12756133 DOI: 10.1001/archneur.60.5.698  1
2003 Sobrido MJ, Abu-Khalil A, Weintraub S, Johnson N, Quinn B, Cummings JL, Mesulam MM, Geschwind DH. Possible association of the tau H1/H1 genotype with primary progressive aphasia. Neurology. 60: 862-4. PMID 12629248  1
2002 Ohira R, Zhang YH, Guo W, Dipple K, Shih SL, Doerr J, Huang BL, Fu LJ, Abu-Khalil A, Geschwind D, McCabe ER. Human ARX gene: genomic characterization and expression. Molecular Genetics and Metabolism. 77: 179-88. PMID 12359145 DOI: 10.1016/S1096-7192(02)00126-9  0.32
2002 Jackson GR, Wiedau-Pazos M, Sang TK, Wagle N, Brown CA, Massachi S, Geschwind DH. Human wild-type tau interacts with wingless pathway components and produces neurofibrillary pathology in Drosophila. Neuron. 34: 509-19. PMID 12062036 DOI: 10.1016/S0896-6273(02)00706-7  1
2002 Dougherty JD, Geschwind DH. Subtraction-coupled custom microarray analysis for gene discovery and gene expression studies in the CNS. Chemical Senses. 27: 293-8. PMID 11923191  1
2002 Sabatti C, Karsten SL, Geschwind DH. Thresholding rules for recovering a sparse signal from microarray experiments. Mathematical Biosciences. 176: 17-34. PMID 11867081 DOI: 10.1016/S0025-5564(01)00102-X  1
2002 Karsten SL, Van Deerlin VM, Sabatti C, Gill LH, Geschwind DH. An evaluation of tyramide signal amplification and archived fixed and frozen tissue in microarray gene expression analysis. Nucleic Acids Research. 30: E4. PMID 11788730  1
2002 Alarcón M, Cantor RM, Liu J, Gilliam TC, Geschwind DH. Evidence for a language quantitative trait locus on chromosome 7q in multiplex autism families. American Journal of Human Genetics. 70: 60-71. PMID 11741194 DOI: 10.1086/338241  1
2001 Kornblum H, Geschwind D. The use of representational difference analysis and cDNA microarrays in neural repair research. Restorative Neurology and Neuroscience. 18: 89-94. PMID 11847431  1
2001 Geschwind DH, Robidoux J, Alarcón M, Miller BL, Wilhelmsen KC, Cummings JL, Nasreddine ZS. Dementia and neurodevelopmental predisposition: cognitive dysfunction in presymptomatic subjects precedes dementia by decades in frontotemporal dementia. Annals of Neurology. 50: 741-6. PMID 11761471 DOI: 10.1002/ana.10024  1
2001 Kornblum HI, Geschwind DH. Molecular markers in CNS stem cell research: hitting a moving target. Nature Reviews. Neuroscience. 2: 843-6. PMID 11715062 DOI: 10.1038/35097597  1
2001 Cholfin JA, Sobrido MJ, Perlman S, Pulst SM, Geschwind DH. The SCA12 mutation as a rare cause of spinocerebellar ataxia. Archives of Neurology. 58: 1833-5. PMID 11708992  1
2001 Figueroa KP, Chan P, Schöls L, Tanner C, Riess O, Perlman SL, Geschwind DH, Pulst SM. Association of moderate polyglutamine tract expansions in the slow calcium-activated potassium channel type 3 with ataxia. Archives of Neurology. 58: 1649-53. PMID 11594924  1
2001 Sobrido MJ, Cholfin JA, Perlman S, Pulst SM, Geschwind DH. SCA8 repeat expansions in ataxia: a controversial association. Neurology. 57: 1310-2. PMID 11591855  1
2001 Geschwind DH, Miller BL. Molecular approaches to cerebral laterality: development and neurodegeneration. American Journal of Medical Genetics. 101: 370-81. PMID 11471161 DOI: 10.1002/1096-8628(20010715)101:4<370::AID-AJMG1223>3.0.CO;2-G  1
2001 Geschwind DH, Sowinski J, Lord C, Iversen P, Shestack J, Jones P, Ducat L, Spence SJ. The autism genetic resource exchange: a resource for the study of autism and related neuropsychiatric conditions. American Journal of Human Genetics. 69: 463-6. PMID 11452364 DOI: 10.1086/321292  1
2001 Liu J, Nyholt DR, Magnussen P, Parano E, Pavone P, Geschwind D, Lord C, Iversen P, Hoh J, Ott J, Gilliam TC. A genomewide screen for autism susceptibility loci. American Journal of Human Genetics. 69: 327-40. PMID 11452361 DOI: 10.1086/321980  1
2001 Terskikh AV, Easterday MC, Li L, Hood L, Kornblum HI, Geschwind DH, Weissman IL. From hematopoiesis to neuropoiesis: evidence of overlapping genetic programs. Proceedings of the National Academy of Sciences of the United States of America. 98: 7934-9. PMID 11438738 DOI: 10.1073/pnas.131200898  1
2001 Boone KB, Swerdloff RS, Miller BL, Geschwind DH, Razani J, Lee A, Gonzalo IG, Haddal A, Rankin K, Lu P, Paul L. Neuropsychological profiles of adults with Klinefelter syndrome. Journal of the International Neuropsychological Society : Jins. 7: 446-56. PMID 11396547 DOI: 10.1017/S1355617701744013  1
2001 Geschwind DH, Ou J, Easterday MC, Dougherty JD, Jackson RL, Chen Z, Antoine H, Terskikh A, Weissman IL, Nelson SF, Kornblum HI. A genetic analysis of neural progenitor differentiation. Neuron. 29: 325-39. PMID 11239426 DOI: 10.1016/S0896-6273(01)00209-4  1
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