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Harinath Chakrapani, Ph.D. - Publications

Affiliations: 
2009- Chemistry IISER Pune, Pune, Maharashtra, India 
Area:
organic chemistry, chemical biology, nitric oxide, reactive oxygen species, redox biology
Website:
www.hclab.in
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74 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2023 Sawase LR, Kumar TA, Mathew AB, Khodade VS, Toscano JP, Saini DK, Chakrapani H. β-Galactosidase-activated nitroxyl (HNO) donors provide insights into redox cross-talk in senescent cells. Chemical Communications (Cambridge, England). 59: 12751-12754. PMID 37811588 DOI: 10.1039/d3cc03094f  0.751
2022 Bora P, Sathian MB, Chakrapani H. Enhancing cellular sulfane sulfur through β-glycosidase-activated persulfide donors: mechanistic insights and oxidative stress mitigation. Chemical Communications (Cambridge, England). PMID 35147153 DOI: 10.1039/d1cc07162a  0.389
2021 Bora P, Manna S, Nair MA, Sathe RRM, Singh S, Sreyas Adury VS, Gupta K, Mukherjee A, Saini DK, Kamat SS, Hazra AB, Chakrapani H. Leveraging an enzyme/artificial substrate system to enhance cellular persulfides and mitigate neuroinflammation. Chemical Science. 12: 12939-12949. PMID 34745524 DOI: 10.1039/d1sc03828a  0.732
2021 Khandelwal N, Shaikh M, Mhetre A, Singh S, Sajeevan T, Joshi A, Balaji KN, Chakrapani H, Kamat SS. Fatty acid chain length drives lysophosphatidylserine-dependent immunological outputs. Cell Chemical Biology. PMID 33571455 DOI: 10.1016/j.chembiol.2021.01.008  0.258
2019 Malwal S, Pardeshi KA, Chakrapani H. Synthesis and evaluation of cyclic sulfite diesters as sulfur dioxide (SO2) donors. Chembiochem : a European Journal of Chemical Biology. PMID 31709695 DOI: 10.1002/Cbic.201900614  0.446
2019 Chauhan P, Gupta K, Govindan R, Saini D, Chakrapani H. Carbonyl Sulfide (COS) Donor induced protein persulfidation protects against oxidative stress. Chemistry, An Asian Journal. PMID 31502759 DOI: 10.1002/Asia.201901148  0.654
2019 Kulkarni A, Soni I, Kelkar D, Dharmaraja AT, Sankar R, Beniwal G, Rajendaran A, Tamhankar S, Chopra S, Kamat SS, Chakrapani H. Chemoproteomics of an Indole-Based Quinone-Epoxide identifies druggable vulnerabilities in Vancomycin Resistant Staphylococcus aureus (VRSA). Journal of Medicinal Chemistry. PMID 31241934 DOI: 10.1021/Acs.Jmedchem.9B00774  0.659
2019 Sharma AK, Singh H, Chakrapani H. Photocontrolled endogenous reactive oxygen species (ROS) generation. Chemical Communications (Cambridge, England). PMID 30993280 DOI: 10.1039/C9Cc01747J  0.55
2019 Kelkar DS, Ravikumar G, Mehendale N, Singh S, Joshi A, Sharma AK, Mhetre A, Rajendran A, Chakrapani H, Kamat SS. A chemical-genetic screen identifies ABHD12 as an oxidized-phosphatidylserine lipase. Nature Chemical Biology. PMID 30643283 DOI: 10.1038/S41589-018-0195-0  0.584
2019 Pardeshi K, Kumar TA, Ravikumar G, Kaul G, Shukla M, Chopra S, Chakrapani H. Targeted Antibacterial Activity Guided by Bacteria-Specific Nitroreductase Catalytic Activation to Produce Ciprofloxacin. Bioconjugate Chemistry. PMID 30615427 DOI: 10.1021/Acs.Bioconjchem.8B00887  0.451
2018 Bora P, Chauhan P, Manna S, Chakrapani H. A Vinyl-Boronate Ester-Based Persulfide Donor Controllable by Hydrogen Peroxide, a Reactive Oxygen Species (ROS). Organic Letters. PMID 30525675 DOI: 10.1021/Acs.Orglett.8B03471  0.491
2018 Kumari P, Kulkarni A, Sharma AK, Chakrapani H. Visible-Light Controlled Release of a Fluoroquinolone Antibiotic for Antimicrobial Photopharmacology. Acs Omega. 3: 2155-2160. PMID 30023825 DOI: 10.1021/acsomega.7b01906  0.658
2018 Chauhan P, Jos S, Chakrapani H. Reactive Oxygen Species-Triggered Tunable Hydrogen Sulfide Release. Organic Letters. PMID 29927612 DOI: 10.1021/Acs.Orglett.8B01356  0.432
2018 Kulkarni A, Sharma AK, Chakrapani H. Redox-guided small molecule antimycobacterials. Iubmb Life. PMID 29761645 DOI: 10.1002/Iub.1867  0.698
2018 Pardeshi KA, Ravikumar G, Chakrapani H. Esterase Sensitive Self-Immolative Sulfur Dioxide Donors. Organic Letters. 20: 4-7. PMID 29235873 DOI: 10.1021/Acs.Orglett.7B02544  0.42
2018 Bora P, Chauhan P, Pardeshi KA, Chakrapani H. Small molecule generators of biologically reactive sulfur species Rsc Advances. 8: 27359-27374. DOI: 10.1039/C8Ra03658F  0.464
2017 Ravikumar G, Bagheri M, Saini DK, Chakrapani H. A small molecule for theraNOstic targeting of cancer cells. Chemical Communications (Cambridge, England). 53: 13352-13355. PMID 29192700 DOI: 10.1039/C7Cc08526E  0.425
2017 Shukla P, Khodade VS, SharathChandra M, Chauhan P, Mishra S, Siddaramappa S, Pradeep BE, Singh A, Chakrapani H. "On demand" redox buffering by H2S contributes to antibiotic resistance revealed by a bacteria-specific H2S donor. Chemical Science. 8: 4967-4972. PMID 28959420 DOI: 10.1039/C7Sc00873B  0.76
2017 Sharma AK, Nair M, Chauhan P, Gupta K, Saini DK, Chakrapani H. Visible-Light-Triggered Uncaging of Carbonyl Sulfide for Hydrogen Sulfide (H2S) Release. Organic Letters. PMID 28872885 DOI: 10.1021/Acs.Orglett.7B02259  0.519
2017 Ravikumar G, Bagheri M, Saini DK, Chakrapani H. FLUORO/NO, a Nitric Oxide Donor with a Fluorescence Reporter. Chembiochem : a European Journal of Chemical Biology. PMID 28470863 DOI: 10.1002/Cbic.201700155  0.485
2016 Chauhan P, Bora P, Ravikumar G, Jos S, Chakrapani H. Esterase Activated Carbonyl Sulfide/Hydrogen Sulfide (H2S) Donors. Organic Letters. PMID 27996277 DOI: 10.1021/Acs.Orglett.6B03336  0.414
2016 Khodade VS, Kulkarni A, Gupta AS, Sengupta K, Chakrapani H. A Small Molecule for Controlled Generation of Peroxynitrite. Organic Letters. PMID 26933774 DOI: 10.1021/Acs.Orglett.6B00186  0.767
2016 Kulkarni A, Soni I, Dharmaraja A, Sankar R, Thakare R, Chopra S, Chakrapani H. Synthesis and biological evaluation of indole-based 2-Aryl-2,3-epoxy-1,4-naphthoquinones as methicillin-resistant staphylococcus aureus (MRSA) inhibitors International Journal of Infectious Diseases. 45: 100-101. DOI: 10.1016/J.Ijid.2016.02.262  0.639
2015 Soni I, Chakrapani H, Chopra S. Draft Genome Sequence of Methicillin-Sensitive Staphylococcus aureus ATCC 29213. Genome Announcements. 3. PMID 26404610 DOI: 10.1128/genomeA.01095-15  0.23
2015 Pardeshi KA, Malwal SR, Banerjee A, Lahiri S, Rangarajan R, Chakrapani H. Thiol activated prodrugs of sulfur dioxide (SO2) as MRSA inhibitors. Bioorganic & Medicinal Chemistry Letters. 25: 2694-7. PMID 25981687 DOI: 10.1016/J.Bmcl.2015.04.046  0.794
2015 Tyagi P, Dharmaraja AT, Bhaskar A, Chakrapani H, Singh A. Mycobacterium tuberculosis has diminished capacity to counteract redox stress induced by elevated levels of endogenous superoxide. Free Radical Biology & Medicine. 84: 344-54. PMID 25819161 DOI: 10.1016/J.Freeradbiomed.2015.03.008  0.501
2015 Malwal SR, Chakrapani H. Benzosulfones as photochemically activated sulfur dioxide (SO2) donors. Organic & Biomolecular Chemistry. 13: 2399-406. PMID 25563212 DOI: 10.1039/C4Ob02466D  0.779
2014 Sankar RK, Kumbhare RS, Dharmaraja AT, Chakrapani H. A phenacrylate scaffold for tunable thiol activation and release. Chemical Communications (Cambridge, England). 50: 15323-6. PMID 25347732 DOI: 10.1039/C4Cc07343F  0.422
2014 Dharmaraja AT, Jain C, Chakrapani H. Substituent effects on reactive oxygen species (ROS) generation by hydroquinones. The Journal of Organic Chemistry. 79: 9413-7. PMID 25207805 DOI: 10.1021/Jo501796Z  0.482
2014 Malwal SR, Labade A, Andhalkar AS, Sengupta K, Chakrapani H. A highly selective sulfinate ester probe for thiol bioimaging Chemical Communications. 50: 11533-11535. PMID 25133745 DOI: 10.1039/C4Cc05462H  0.747
2014 Sharma K, Chakrapani H. Site-directed delivery of nitric oxide to cancers. Nitric Oxide : Biology and Chemistry / Official Journal of the Nitric Oxide Society. 43: 8-16. PMID 25124221 DOI: 10.1016/J.Niox.2014.07.005  0.613
2014 Khodade VS, Sharath Chandra M, Banerjee A, Lahiri S, Pulipeta M, Rangarajan R, Chakrapani H. Bioreductively Activated Reactive Oxygen Species (ROS) Generators as MRSA Inhibitors. Acs Medicinal Chemistry Letters. 5: 777-81. PMID 25050164 DOI: 10.1021/Ml5001118  0.786
2014 Dharmaraja AT, Ravikumar G, Chakrapani H. Arylboronate ester based diazeniumdiolates (BORO/NO), a class of hydrogen peroxide inducible nitric oxide (NO) donors. Organic Letters. 16: 2610-3. PMID 24796212 DOI: 10.1021/Ol5010643  0.512
2014 Dharmaraja AT, Chakrapani H. A small molecule for controlled generation of reactive oxygen species (ROS). Organic Letters. 16: 398-401. PMID 24372330 DOI: 10.1021/Ol403300A  0.455
2013 Sharma K, Sengupta K, Chakrapani H. Nitroreductase-activated nitric oxide (NO) prodrugs. Bioorganic & Medicinal Chemistry Letters. 23: 5964-7. PMID 24050886 DOI: 10.1016/J.Bmcl.2013.08.066  0.633
2013 Sharma K, Iyer A, Sengupta K, Chakrapani H. INDQ/NO, a bioreductively activated nitric oxide prodrug. Organic Letters. 15: 2636-9. PMID 23659457 DOI: 10.1021/Ol400884V  0.632
2013 Malwal SR, Gudem M, Hazra A, Chakrapani H. Benzosultines as sulfur dioxide (SO2) donors. Organic Letters. 15: 1116-9. PMID 23421429 DOI: 10.1021/Ol400190F  0.745
2013 Deschamps JR, Saavedra JE, Cao Z, Keefer LK, Chakrapani H. Stereochemical origins of chromophore extension in O2- substituted diazeniumdiolates, prodrugs of nitric oxide Journal of Chemical Crystallography. 43: 123-126. DOI: 10.1007/S10870-013-0394-1  0.41
2012 Maciag AE, Holland RJ, Saavedra JE, Chakrapani H, Shami PJ, Keefer LK. Thiol Modification By Pharmacologically Active Agents of the Diazeniumdiolate Class. Forum On Immunopathological Diseases and Therapeutics. 3: 91-95. PMID 23585982 DOI: 10.1615/Forumimmundisther.2012006334  0.386
2012 Holland RJ, Maciag AE, Kumar V, Shi L, Saavedra JE, Prud'homme RK, Chakrapani H, Keefer LK. Cross-linking protein glutathionylation mediated by O2-arylated bis-diazeniumdiolate "Double JS-K". Chemical Research in Toxicology. 25: 2670-7. PMID 23106594 DOI: 10.1021/Tx3003142  0.404
2012 Dharmaraja AT, Alvala M, Sriram D, Yogeeswari P, Chakrapani H. Design, synthesis and evaluation of small molecule reactive oxygen species generators as selective Mycobacterium tuberculosis inhibitors. Chemical Communications (Cambridge, England). 48: 10325-7. PMID 22977884 DOI: 10.1039/C2Cc35343A  0.451
2012 Malwal SR, Sriram D, Yogeeswari P, Chakrapani H. Synthesis and antimycobacterial activity of prodrugs of sulfur dioxide (SO2). Bioorganic & Medicinal Chemistry Letters. 22: 3603-6. PMID 22572576 DOI: 10.1016/J.Bmcl.2012.04.048  0.789
2012 Khodade VS, Dharmaraja AT, Chakrapani H. Synthesis, reactive oxygen species generation and copper-mediated nuclease activity profiles of 2-aryl-3-amino-1,4-naphthoquinones. Bioorganic & Medicinal Chemistry Letters. 22: 3766-9. PMID 22542016 DOI: 10.1016/J.Bmcl.2012.04.009  0.771
2012 Malwal SR, Sriram D, Yogeeswari P, Konkimalla VB, Chakrapani H. Design, synthesis, and evaluation of thiol-activated sources of sulfur dioxide (SO₂) as antimycobacterial agents. Journal of Medicinal Chemistry. 55: 553-7. PMID 22128803 DOI: 10.1021/Jm201023G  0.77
2012 Dharmaraja AT, Dash TK, Konkimalla VB, Chakrapani H. Synthesis, thiol-mediated reactive oxygen species generation profiles and anti-proliferative activities of 2,3-epoxy-1,4-naphthoquinones Medchemcomm. 3: 219-224. DOI: 10.1039/C1Md00234A  0.483
2012 Chakrapani H, Sharma K. Bioreductively-Activated Prodrugs of Nitric Oxide (NO) Free Radical Biology and Medicine. 53: S179. DOI: 10.1016/J.Freeradbiomed.2012.10.491  0.618
2012 Chakrapani H, Dharmaraja AT. Design, Synthesis and Study of Reactive Oxygen Species Generators as Mycobacterium Tuberculosis Inhibitors Free Radical Biology and Medicine. 53. DOI: 10.1016/J.Freeradbiomed.2012.10.243  0.436
2011 Maciag AE, Nandurdikar RS, Hong SY, Chakrapani H, Diwan B, Morris NL, Shami PJ, Shiao YH, Anderson LM, Keefer LK, Saavedra JE. Activation of the c-Jun N-terminal kinase/activating transcription factor 3 (ATF3) pathway characterizes effective arylated diazeniumdiolate-based nitric oxide-releasing anticancer prodrugs. Journal of Medicinal Chemistry. 54: 7751-8. PMID 22003962 DOI: 10.1021/Jm2004128  0.505
2011 Maciag AE, Chakrapani H, Saavedra JE, Morris NL, Holland RJ, Kosak KM, Shami PJ, Anderson LM, Keefer LK. The nitric oxide prodrug JS-K is effective against non-small-cell lung cancer cells in vitro and in vivo: involvement of reactive oxygen species. The Journal of Pharmacology and Experimental Therapeutics. 336: 313-20. PMID 20962031 DOI: 10.1124/Jpet.110.174904  0.452
2010 Hong SY, Borchert GL, Maciag AE, Nandurdikar RS, Saavedra JE, Keefer LK, Phang JM, Chakrapani H. The Nitric Oxide Prodrug V-PROLI/NO Inhibits Cellular Uptake of Proline. Acs Medicinal Chemistry Letters. 1: 386-389. PMID 21212855 DOI: 10.1021/Ml1000905  0.423
2010 Kumar V, Hong SY, Maciag AE, Saavedra JE, Adamson DH, Prud'homme RK, Keefer LK, Chakrapani H. Stabilization of the nitric oxide (NO) prodrugs and anticancer leads, PABA/NO and Double JS-K, through incorporation into PEG-protected nanoparticles. Molecular Pharmaceutics. 7: 291-8. PMID 20000791 DOI: 10.1021/Mp900245H  0.31
2010 Nandurdikar RS, Maciag AE, Hong SY, Chakrapani H, Citro ML, Keefer LK, Saavedra JE. Glycosylated PROLI/NO derivatives as nitric oxide prodrugs. Organic Letters. 12: 56-9. PMID 19954198 DOI: 10.1021/Ol902481S  0.476
2010 Maciag AE, Chakrapani H, Holland RJ, Morris NL, Shami PJ, Saavedra JE, Anderson LM, Keefer LK. Abstract 4547: Diazeniumdiolate-based nitric oxide-releasing prodrugs kill lung adenocarcinoma cells in culture and in vivo through alterations in cellular redox balance leading to mitochondrially-mediated apoptosis Cancer Research. 70: 4547-4547. DOI: 10.1158/1538-7445.Am10-4547  0.387
2009 Rai G, Sayed AA, Lea WA, Luecke HF, Chakrapani H, Prast-Nielsen S, Jadhav A, Leister W, Shen M, Inglese J, Austin CP, Keefer L, Arnér ES, Simeonov A, Maloney DJ, et al. Structure mechanism insights and the role of nitric oxide donation guide the development of oxadiazole-2-oxides as therapeutic agents against schistosomiasis. Journal of Medicinal Chemistry. 52: 6474-83. PMID 19761212 DOI: 10.1021/Jm901021K  0.497
2009 Maciag AE, Saavedra JE, Chakrapani H. The nitric oxide prodrug JS-K and its structural analogues as cancer therapeutic agents. Anti-Cancer Agents in Medicinal Chemistry. 9: 798-803. PMID 19538173 DOI: 10.2174/187152009789056949  0.452
2009 Nandurdikar RS, Maciag AE, Citro ML, Shami PJ, Keefer LK, Saavedra JE, Chakrapani H. Synthesis and evaluation of piperazine and homopiperazine analogues of JS-K, an anti-cancer lead compound. Bioorganic & Medicinal Chemistry Letters. 19: 2760-2. PMID 19364650 DOI: 10.1016/J.Bmcl.2009.03.115  0.475
2009 Chakrapani H, Bartberger MD, Toone EJ. C-nitroso donors of nitric oxide. The Journal of Organic Chemistry. 74: 1450-3. PMID 19146387 DOI: 10.1021/Jo802517T  0.681
2009 Maciag AE, Chakrapani H, Shami PJ, Saavedra JE, Anderson LM, Keefer LK. Abstract C102: Reactive oxygen species‐related killing of lung adenocarcinoma cells in culture and in vivo by diazeniumdiolate‐based nitric oxide‐releasing prodrugs Molecular Cancer Therapeutics. 8. DOI: 10.1158/1535-7163.Targ-09-C102  0.466
2009 Hong SY, Nandurdikar RS, Keefer LK, Saavedra JE, Chakrapani H. An improved synthesis of V-PROLI/NO, a cytochrome P450-activated nitric oxide prodrug Tetrahedron Letters. 50: 4545-4548. DOI: 10.1016/J.Tetlet.2009.05.089  0.432
2009 Hong SY, Saavedra JE, Keefer LK, Chakrapani H. Improved synthesis of V-PYRRO/NO, a liver-selective nitric oxide prodrug, and analogues Tetrahedron Letters. 50: 2069-2071. DOI: 10.1016/J.Tetlet.2009.02.103  0.407
2008 Andrei D, Maciag AE, Chakrapani H, Citro ML, Keefer LK, Saavedra JE. Aryl bis(diazeniumdiolates): potent inducers of S-glutathionylation of cellular proteins and their in vitro antiproliferative activities. Journal of Medicinal Chemistry. 51: 7944-52. PMID 19053760 DOI: 10.1021/Jm800831Y  0.495
2008 Chakrapani H, Maciag AE, Citro ML, Keefer LK, Saavedra JE. Cell-permeable esters of diazeniumdiolate-based nitric oxide prodrugs. Organic Letters. 10: 5155-8. PMID 18956868 DOI: 10.1021/Ol8020989  0.496
2008 Chakrapani H, Kalathur RC, Maciag AE, Citro ML, Ji X, Keefer LK, Saavedra JE. Synthesis, mechanistic studies, and anti-proliferative activity of glutathione/glutathione S-transferase-activated nitric oxide prodrugs. Bioorganic & Medicinal Chemistry. 16: 9764-71. PMID 18930407 DOI: 10.1016/J.Bmc.2008.09.063  0.478
2008 Chakrapani H, Goodblatt MM, Udupi V, Malaviya S, Shami PJ, Keefer LK, Saavedra JE. Synthesis and in vitro anti-leukemic activity of structural analogues of JS-K, an anti-cancer lead compound. Bioorganic & Medicinal Chemistry Letters. 18: 950-3. PMID 18178089 DOI: 10.1016/J.Bmcl.2007.12.044  0.469
2008 Chakrapani H, Wilde TC, Citro ML, Goodblatt MM, Keefer LK, Saavedra JE. Synthesis, nitric oxide release, and anti-leukemic activity of glutathione-activated nitric oxide prodrugs: Structural analogues of PABA/NO, an anti-cancer lead compound. Bioorganic & Medicinal Chemistry. 16: 2657-64. PMID 18060792 DOI: 10.1016/J.Bmc.2007.11.035  0.519
2007 Chakrapani H, Showalter BM, Citro ML, Keefer LK, Saavedra JE. Nitric oxide prodrugs: diazeniumdiolate anions of hindered secondary amines. Organic Letters. 9: 4551-4. PMID 17918856 DOI: 10.1021/Ol7019636  0.444
2007 Chakrapani H, Showalter BM, Kong L, Keefer LK, Saavedra JE. V-PROLI/NO, a prodrug of the nitric oxide donor, PROLI/NO. Organic Letters. 9: 3409-12. PMID 17658755 DOI: 10.1021/Ol701419A  0.439
2006 Chakrapani H, Gorczynski MJ, King SB. Allylic nitro compounds as nitrite donors. Journal of the American Chemical Society. 128: 16332-7. PMID 17165788 DOI: 10.1021/Ja066011V  0.557
2006 Chakrapani H, King SB. P175. Allylic nitro compounds as sources of nitrite Nitric Oxide. 14: 74. DOI: 10.1016/J.Niox.2006.04.244  0.472
2005 Gooden DM, Chakrapani H, Toone EJ. C-nitroso compounds: synthesis, physicochemical properties and biological activities. Current Topics in Medicinal Chemistry. 5: 687-705. PMID 16101429 DOI: 10.2174/1568026054679353  0.794
2005 Pamula VK, Srinivasan V, Chakrapani H, Fair RB, Toone EJ. A droplet-based lab-on-a-chip for colorimetric detection of nitroaromatic explosives Proceedings of the Ieee International Conference On Micro Electro Mechanical Systems (Mems). 722-725. DOI: 10.1109/MEMSYS.2005.1454031  0.527
2003 Chakrapani H, Liu C, Widenhoefer RA. Enantioselective cyclization/hydrosilylation of 1,6-enynes catalyzed by a cationic rhodium bis(phosphine) complex. Organic Letters. 5: 157-9. PMID 12529129 DOI: 10.1021/Ol027196N  0.349
2002 Wang X, Chakrapani H, Madine JW, Keyerleber MA, Widenhoefer RA. Cyclization/hydrosilylation of functionalized 1,6-diynes catalyzed by cationic platinum complexes containing bidentate nitrogen ligands. The Journal of Organic Chemistry. 67: 2778-88. PMID 11975528 DOI: 10.1021/Jo015986P  0.387
2001 Wang X, Chakrapani H, Stengone CN, Widenhoefer RA. Synthesis of carbobicyclic compounds via palladium-catalyzed cyclization/hydrosilylation: evidence for reversible silylpalladation. The Journal of Organic Chemistry. 66: 1755-60. PMID 11262123 DOI: 10.1021/Jo001438K  0.393
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