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Romano V.A. Orru - Publications

Affiliations: 
chemistry Vrije Universiteit Amsterdam, Amsterdam, Netherlands 
Area:
Synthetic and Bioorganic Chemistry
Website:
http://www.chem.vu.nl/~oac/ro.htm
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67 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2023 Bonnemaire CM, Windhorst AD, Orru R, Ruijter E, Vugts DJ. [11C]CO2 BOP fixation with amines to access 11C-labeled ureas for PET imaging. Journal of Labelled Compounds & Radiopharmaceuticals. PMID 38073118 DOI: 10.1002/jlcr.4075  0.559
2019 Collet JW, Roose TR, Ruijter E, Maes BUW, Orru R. Base Metal-Catalyzed Isocyanide Insertions. Angewandte Chemie (International Ed. in English). PMID 31287627 DOI: 10.1002/Anie.201905838  0.378
2019 Ruijter E, Orru R. Multicomponent reactions in drug discovery and medicinal chemistry. Drug Discovery Today. Technologies. 29: 1-2. PMID 30471667 DOI: 10.1016/J.Ddtec.2018.11.002  0.412
2017 Kruithof A, Vande Velde CM, Ruijter E, Orru RV. Thiazine-2-thiones as Masked 1-Azadienes in Cascade Dimerization Reactions). Molecules (Basel, Switzerland). 22. PMID 28350361 DOI: 10.3390/Molecules22040541  0.437
2017 Cioc RC, Estévez V, van der Niet DJ, Vande Velde CM, Turrini NG, Hall M, Faber K, Ruijter E, Orru RV. Stereoselective Synthesis of Functionalized Bicyclic Scaffolds by Passerini 3-Center-2-Component Reactions of Cyclic Ketoacids. European Journal of Organic Chemistry. 2017: 1262-1271. PMID 28344504 DOI: 10.1002/Ejoc.201601432  0.526
2016 Saya JM, Oppelaar B, Cioc RC, van der Heijden G, Vande Velde CM, Orru RV, Ruijter E. Synthesis of polycyclic spiroindolines by highly diastereoselective interrupted Ugi cascade reactions of 3-(2-isocyanoethyl)indoles. Chemical Communications (Cambridge, England). PMID 27722446 DOI: 10.1039/C6Cc07459F  0.557
2016 van der Heijden G, Kraakman J, Biemolt J, Ruijter E, Orru RV. Metal-free one-pot α-carboxylation of primary alcohols. Organic & Biomolecular Chemistry. PMID 27722407 DOI: 10.1039/C6Ob01813K  0.338
2016 Zhu YP, Sergeyev S, Franck P, Orru RV, Maes BU. Amine Activation: Synthesis of N-(Hetero)arylamides from Isothioureas and Carboxylic Acids. Organic Letters. PMID 27570902 DOI: 10.1021/Acs.Orglett.6B02247  0.455
2016 Cioc RC, Schuckman P, Preschel HD, Vlaar T, Ruijter E, Orru RV. Brønsted Acid-Catalyzed Cyanotritylation of Aldehydes by Trityl Isocyanide. Organic Letters. PMID 27404343 DOI: 10.1021/Acs.Orglett.6B01481  0.436
2016 Mampuys P, Zhu Y, Sergeyev S, Ruijter E, Orru RV, Van Doorslaer S, Maes BU. Iodide-Catalyzed Synthesis of Secondary Thiocarbamates from Isocyanides and Thiosulfonates. Organic Letters. PMID 27276236 DOI: 10.1021/Acs.Orglett.6B01023  0.566
2016 Cioc RC, Preschel HD, van der Heijden G, Ruijter E, Orru RV. Trityl Isocyanide as a Mechanistic Probe in Multicomponent Chemistry: Walking the Line between Ugi- and Strecker-type Reactions. Chemistry (Weinheim An Der Bergstrasse, Germany). PMID 27112103 DOI: 10.1002/Chem.201600285  0.461
2016 Wu XF, Zhu F, Li Y, Wang Z, Orru RV, Maes BU. Palladium-Catalyzed Construction of Amidines from Arylboronic acids under Oxidative Conditions. Chemistry (Weinheim An Der Bergstrasse, Germany). PMID 27061735 DOI: 10.1002/Chem.201601262  0.461
2016 van der Heijden G, Jong JA, Ruijter E, Orru RV. 2-Bromo-6-isocyanopyridine as a Universal Convertible Isocyanide for Multicomponent Chemistry. Organic Letters. PMID 26849150 DOI: 10.1021/Acs.Orglett.6B00091  0.409
2016 Ruijter E, Orru R, Cioc R, Schaepkens van Riempst L, Schuckman P. Ugi Four-Center Three-Component Reaction as a Direct Approach to Racetams Synthesis. 49: 1664-1674. DOI: 10.1055/S-0036-1588672  0.493
2016 Ruijter E, Orru R, Estévez V, Kloeters L, Kwietniewska N, Vicente-García E. Ugi-Type Reactions of Spirocyclic Indolenines as a Platform for Compound Library Generation Synlett. 28: 376-380. DOI: 10.1055/S-0036-1588084  0.479
2015 de Graaff C, Bensch L, Boersma SJ, Cioc RC, van Lint MJ, Janssen E, Turner NJ, Orru RV, Ruijter E. Asymmetric Synthesis of Tetracyclic Pyrroloindolines and Constrained Tryptamines by a Switchable Cascade Reaction. Angewandte Chemie (International Ed. in English). PMID 26404737 DOI: 10.1002/Anie.201507041  0.551
2015 de Graaff C, Bensch L, van Lint MJ, Ruijter E, Orru RV. IBX-mediated oxidation of unactivated cyclic amines: application in highly diastereoselective oxidative Ugi-type and aza-Friedel-Crafts reactions. Organic & Biomolecular Chemistry. PMID 26368318 DOI: 10.1039/C5Ob01519G  0.415
2015 Cioc RC, van der Niet DJ, Janssen E, Ruijter E, Orru RV. One-Pot Synthesis of N-Substituted β-Amino Alcohols from Aldehydes and Isocyanides. Chemistry (Weinheim An Der Bergstrasse, Germany). 21: 7808-13. PMID 25868115 DOI: 10.1002/Chem.201500210  0.423
2015 Kruithof A, Ruijter E, Orru RV. Synthesis of heterocycles by formal cycloadditions of isocyanides. Chemistry, An Asian Journal. 10: 508-20. PMID 25504958 DOI: 10.1002/Asia.201403207  0.537
2015 Bouwman S, Orru RV, Ruijter E. Stereoselective synthesis of fluorinated aminoglycosyl phosphonates. Organic & Biomolecular Chemistry. 13: 1317-21. PMID 25491168 DOI: 10.1039/C4Ob02317J  0.447
2014 Janssen GV, Janssen E, Vande Velde CM, Ehlers AW, Slootweg JC, Ruijter E, Lammertsma K, Orru RV. Chemoselective addition of isocyanides to N-tert-butanesulfinimines. Organic Letters. 16: 5116-9. PMID 25229182 DOI: 10.1021/Ol502463S  0.453
2014 Mampuys P, Zhu Y, Vlaar T, Ruijter E, Orru RV, Maes BU. Sustainable three-component synthesis of isothioureas from isocyanides, thiosulfonates, and amines. Angewandte Chemie (International Ed. in English). 53: 12849-54. PMID 25223494 DOI: 10.1002/Anie.201406717  0.504
2014 van der Born D, Sewing C, Herscheid JK, Windhorst AD, Orru RV, Vugts DJ. A universal procedure for the [¹⁸F]trifluoromethylation of aryl iodides and aryl boronic acids with highly improved specific activity. Angewandte Chemie (International Ed. in English). 53: 11046-50. PMID 25155042 DOI: 10.1002/Anie.201406221  0.652
2014 Janssen GV, Slobbe P, Mooijman M, Kruithof A, Ehlers AW, Guerra CF, Bickelhaupt FM, Slootweg JC, Ruijter E, Lammertsma K, Orru RV. Diastereoselective one-pot synthesis of tetrafunctionalized 2-imidazolines. The Journal of Organic Chemistry. 79: 5219-26. PMID 24820129 DOI: 10.1021/Jo500790N  0.557
2014 Koopmanschap G, Ruijter E, Orru RV. Isocyanide-based multicomponent reactions towards cyclic constrained peptidomimetics. Beilstein Journal of Organic Chemistry. 10: 544-98. PMID 24605172 DOI: 10.3762/Bjoc.10.50  0.456
2013 Vlaar T, Orru RV, Maes BU, Ruijter E. Palladium-catalyzed synthesis of 2-aminobenzoxazinones by aerobic oxidative coupling of anthranilic acids and isocyanides. The Journal of Organic Chemistry. 78: 10469-75. PMID 24063265 DOI: 10.1021/Jo401924H  0.445
2013 Ruijter E, Orru RV. Multicomponent reactions - opportunities for the pharmaceutical industry. Drug Discovery Today. Technologies. 10: e15-20. PMID 24050225 DOI: 10.1016/J.Ddtec.2012.10.012  0.517
2013 Vlaar T, Mampuys P, Helliwell M, Maes BU, Orru RV, Ruijter E. Multicomponent synthesis of 4-aminophthalazin-1(2H)-ones by palladium-catalyzed isocyanide insertion. The Journal of Organic Chemistry. 78: 6735-45. PMID 23768066 DOI: 10.1021/Jo401131P  0.417
2013 Vlaar T, Ruijter E, Maes BU, Orru RV. Palladium-catalyzed migratory insertion of isocyanides: an emerging platform in cross-coupling chemistry. Angewandte Chemie (International Ed. in English). 52: 7084-97. PMID 23754476 DOI: 10.1002/Anie.201300942  0.554
2013 van der Born D, Herscheid JK, Orru RV, Vugts DJ. Efficient synthesis of [18F]trifluoromethane and its application in the synthesis of PET tracers. Chemical Communications (Cambridge, England). 49: 4018-20. PMID 23563284 DOI: 10.1039/C3Cc37833K  0.619
2013 Musa C, Licheri R, Orru R, Cao G. Fabrication of Fully Dense UHTC by Combining SHS and SPS Eurasian Chemico-Technological Journal. 15: 117-126. DOI: 10.18321/Ectj149  0.321
2012 Vlaar T, Cioc RC, Mampuys P, Maes BU, Orru RV, Ruijter E. Sustainable synthesis of diverse privileged heterocycles by palladium-catalyzed aerobic oxidative isocyanide insertion. Angewandte Chemie (International Ed. in English). 51: 13058-61. PMID 23161862 DOI: 10.1002/Anie.201207410  0.327
2012 de Graaff C, Ruijter E, Orru RV. Recent developments in asymmetric multicomponent reactions. Chemical Society Reviews. 41: 3969-4009. PMID 22546840 DOI: 10.1039/C2Cs15361K  0.557
2012 Kruithof A, Ploeger ML, Janssen E, Helliwell M, de Kanter FJ, Ruijter E, Orru RV. Multicomponent synthesis of 3,6-dihydro-2H-1,3-thiazine-2-thiones. Molecules (Basel, Switzerland). 17: 1675-85. PMID 22318323 DOI: 10.3390/Molecules17021675  0.463
2012 Znabet A, Blanken S, Janssen E, de Kanter FJ, Helliwell M, Turner NJ, Ruijter E, Orru RV. Stereoselective synthesis of N-aryl proline amides by biotransformation-Ugi-Smiles sequence. Organic & Biomolecular Chemistry. 10: 941-4. PMID 22179495 DOI: 10.1039/C1Ob06699D  0.387
2011 Van Baelen G, Kuijer S, Rý?ek L, Sergeyev S, Janssen E, de Kanter FJ, Maes BU, Ruijter E, Orru RV. Synthesis of 4-aminoquinazolines by palladium-catalyzed intramolecular imidoylation of N-(2-bromoaryl)amidines. Chemistry (Weinheim An Der Bergstrasse, Germany). 17: 15039-44. PMID 22125085 DOI: 10.1002/Chem.201102468  0.518
2011 Vlaar T, Ruijter E, Znabet A, Janssen E, de Kanter FJ, Maes BU, Orru RV. Palladium-catalyzed synthesis of 4-aminophthalazin-1(2H)-ones by isocyanide insertion. Organic Letters. 13: 6496-9. PMID 22085248 DOI: 10.1021/Ol202784D  0.414
2011 Ruijter E, Scheffelaar R, Orru RV. Multicomponent reaction design in the quest for molecular complexity and diversity. Angewandte Chemie (International Ed. in English). 50: 6234-46. PMID 21710674 DOI: 10.1002/Anie.201006515  0.476
2010 Znabet A, Zonneveld J, Janssen E, De Kanter FJ, Helliwell M, Turner NJ, Ruijter E, Orru RV. Asymmetric synthesis of synthetic alkaloids by a tandem biocatalysis/Ugi/Pictet-Spengler-type cyclization sequence. Chemical Communications (Cambridge, England). 46: 7706-8. PMID 20871902 DOI: 10.1039/C0Cc02938F  0.494
2010 Znabet A, Polak MM, Janssen E, de Kanter FJ, Turner NJ, Orru RV, Ruijter E. A highly efficient synthesis of telaprevir by strategic use of biocatalysis and multicomponent reactions. Chemical Communications (Cambridge, England). 46: 7918-20. PMID 20856952 DOI: 10.1039/C0Cc02823A  0.538
2010 Gulevich AV, Zhdanko AG, Orru RV, Nenajdenko VG. Isocyanoacetate derivatives: synthesis, reactivity, and application. Chemical Reviews. 110: 5235-331. PMID 20608735 DOI: 10.1021/Cr900411F  0.431
2010 Znabet A, Ruijter E, de Kanter FJ, Köhler V, Helliwell M, Turner NJ, Orru RV. Highly stereoselective synthesis of substituted prolyl peptides using a combination of biocatalytic desymmetrization and multicomponent reactions. Angewandte Chemie (International Ed. in English). 49: 5289-92. PMID 20575127 DOI: 10.1002/Anie.201001592  0.478
2010 Scheffelaar R, Paravidino M, Znabet A, Schmitz RF, de Kanter FJ, Lutz M, Spek AL, Fonseca Guerra C, Bickelhaupt FM, Groen MB, Ruijter E, Orru RV. Scope and limitations of an efficient four-component reaction for dihydropyridin-2-ones. The Journal of Organic Chemistry. 75: 1723-32. PMID 20121230 DOI: 10.1021/Jo902613J  0.479
2010 Orru R, Znabet A, Ruijter E, de Kanter F, Köhler V, Helliwell M, Turner N. Complex Prolyl Peptides in Two Steps: Biocatalysis and Ugi Reaction Synfacts. 2010: 1067-1067. DOI: 10.1055/S-0030-1257963  0.404
2009 Elders N, van der Born D, Hendrickx LJ, Timmer BJ, Krause A, Janssen E, de Kanter FJ, Ruijter E, Orru RV. The efficient one-pot reaction of up to eight components by the union of multicomponent reactions. Angewandte Chemie (International Ed. in English). 48: 5856-9. PMID 19579257 DOI: 10.1002/Anie.200902683  0.544
2009 Martha CT, Heemskerk A, Hoogendoorn JC, Elders N, Niessen WM, Orru RV, Irth H. High-throughput reaction optimisation and activity screening of ferrocene-based Lewis acid-catalyst complexes by using continuous-flow reaction detection mass spectrometry. Chemistry (Weinheim An Der Bergstrasse, Germany). 15: 7368-75. PMID 19551778 DOI: 10.1002/Chem.200900317  0.411
2009 Elders N, Ruijter E, de Kanter FJ, Janssen E, Lutz M, Spek AL, Orru RV. A multicomponent reaction towards N-(cyanomethyl)amides. Chemistry (Weinheim An Der Bergstrasse, Germany). 15: 6096-9. PMID 19462390 DOI: 10.1002/Chem.200900785  0.567
2009 Scheffelaar R, Nijenhuis RA, Paravidino M, Lutz M, Spek AL, Ehlers AW, de Kanter FJ, Groen MB, Orru RV, Ruijter E. Synthesis of conformationally constrained peptidomimetics using multicomponent reactions. The Journal of Organic Chemistry. 74: 660-8. PMID 19055378 DOI: 10.1021/Jo802052J  0.385
2009 Scheffelaar R, Paravidino M, Muilwijk D, Lutz M, Spek AL, de Kanter FJ, Orru RV, Ruijter E. A novel three-component reaction toward dihydrooxazolopyridines. Organic Letters. 11: 125-8. PMID 19053816 DOI: 10.1021/Ol802515V  0.566
2008 Groenendaal B, Ruijter E, Orru RV. 1-Azadienes in cycloaddition and multicomponent reactions towards N-heterocycles. Chemical Communications (Cambridge, England). 5474-89. PMID 18997927 DOI: 10.1039/B809206K  0.563
2008 Martha CT, Elders N, Krabbe JG, Kool J, Niessen WM, Orru RV, Irth H. Online screening of homogeneous catalyst performance using reaction detection mass spectrometry. Analytical Chemistry. 80: 7121-7. PMID 18698801 DOI: 10.1021/Ac801003H  0.338
2008 Groenendaal B, Ruijter E, de Kanter FJ, Lutz M, Spek AL, Orru RV. Generation of molecular diversity using a complexity-generating MCR-platform towards triazinane diones. Organic & Biomolecular Chemistry. 6: 3158-65. PMID 18698475 DOI: 10.1039/B807138A  0.524
2008 Elders N, Ruijter E, de Kanter FJ, Groen MB, Orru RV. Selective formation of 2-imidazolines and 2-substituted oxazoles by using a three-component reaction. Chemistry (Weinheim An Der Bergstrasse, Germany). 14: 4961-73. PMID 18431735 DOI: 10.1002/Chem.200800271  0.519
2008 Groenendaal B, Vugts DJ, Schmitz RF, de Kanter FJ, Ruijter E, Groen MB, Orru RV. A multicomponent synthesis of triazinane diones. The Journal of Organic Chemistry. 73: 719-22. PMID 18095703 DOI: 10.1021/Jo701973D  0.684
2008 Bon RS, Sprenkels NE, Koningstein MM, Schmitz RF, de Kanter FJ, Dömling A, Groen MB, Orru RV. Efficient C2 functionalisation of 2H-2-imidazolines. Organic & Biomolecular Chemistry. 6: 130-7. PMID 18075657 DOI: 10.1039/B713065A  0.419
2007 Paravidino M, Scheffelaar R, Schmitz RF, Kanter FJ, Groen MB, Ruijter E, Orru RV. A flexible six-component reaction to access constrained depsipeptides based on a dihydropyridinone core. The Journal of Organic Chemistry. 72: 10239-42. PMID 17997575 DOI: 10.1021/Jo701978V  0.525
2007 Elders N, Schmitz RF, de Kanter FJ, Ruijter E, Groen MB, Orru RV. A resource-efficient and highly flexible procedure for a three-component synthesis of 2-imidazolines. The Journal of Organic Chemistry. 72: 6135-42. PMID 17628108 DOI: 10.1021/Jo070840X  0.502
2007 Orru R, Vugts D, Koningstein M, Schmitz R, de Kanter F, Groen M. Synthesis of Dihydropyrimidones and Thiazines by a Multicomponent Reaction Synfacts. 2007: 0144-0144. DOI: 10.1055/S-2006-955828  0.721
2007 Artizzu F, Marchio L, Mercuri ML, Pilia L, Serpe A, Quochi F, Orru R, Cordella F, Saba M, Mura AA, Bongiovanni GLC, Deplano P. New Insights on Near‐Infrared Emitters Based on Er‐quinolinolate Complexes: Synthesis, Characterization, Structural, and Photophysical Properties Advanced Functional Materials. 17: 2365-2376. DOI: 10.1002/Adfm.200600926  0.328
2006 Paravidino M, Bon RS, Scheffelaar R, Vugts DJ, Znabet A, Schmitz RF, de Kanter FJ, Lutz M, Spek AL, Groen MB, Orru RV. Diastereoselective multicomponent synthesis of dihydropyridones with an isocyanide functionality. Organic Letters. 8: 5369-72. PMID 17078720 DOI: 10.1021/Ol062204B  0.697
2006 Vugts DJ, Koningstein MM, Schmitz RF, de Kanter FJ, Groen MB, Orru RV. Multicomponent synthesis of dihydropyrimidines and thiazines. Chemistry (Weinheim An Der Bergstrasse, Germany). 12: 7178-89. PMID 16847990 DOI: 10.1002/Chem.200600168  0.712
2006 Gelens E, De Kanter FJ, Schmitz RF, Sliedregt LA, Van Steen BJ, Kruse CG, Leurs R, Groen MB, Orru RV. Efficient library synthesis of imidazoles using a multicomponent reaction and microwave irradiation. Molecular Diversity. 10: 17-22. PMID 16404525 DOI: 10.1007/S11030-006-8695-3  0.488
2005 Bon RS, van Vliet B, Sprenkels NE, Schmitz RF, de Kanter FJ, Stevens CV, Swart M, Bickelhaupt FM, Groen MB, Orru RV. Multicomponent synthesis of 2-imidazolines. The Journal of Organic Chemistry. 70: 3542-53. PMID 15844989 DOI: 10.1021/Jo050132G  0.451
2003 Vugts DJ, Jansen H, Schmitz RF, de Kanter FJ, Orru RV. A novel four-component reaction for the synthesis of functionalised dihydropyrimidines. Chemical Communications (Cambridge, England). 2594-5. PMID 14594297 DOI: 10.1039/B308243A  0.708
2003 Bon RS, Hong C, Bouma MJ, Schmitz RF, de Kanter FJ, Lutz M, Spek AL, Orru RV. Novel multicomponent reaction for the combinatorial synthesis of 2-imidazolines. Organic Letters. 5: 3759-62. PMID 14507224 DOI: 10.1021/Ol035521G  0.568
2002 Schrekker HS, de Bolster MW, Orru RV, Wessjohann LA. In situ formation of allyl ketones via Hiyama-Nozaki reactions followed by a chromium-mediated Oppenauer oxidation. The Journal of Organic Chemistry. 67: 1975-81. PMID 11925200 DOI: 10.1021/Jo001750U  0.624
1999 Orru RV, Archelas A, Furstoss R, Faber K. Epoxide hydrolases and their synthetic applications. Advances in Biochemical Engineering/Biotechnology. 63: 145-67. PMID 9933984 DOI: 10.1007/3-540-69791-8_7  0.472
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