| Year |
Citation |
Score |
| 2024 |
Zarca A, Adlere I, Viciano CP, Arimont-Segura M, Meyrath M, Simon IA, Bebelman JP, Laan D, Custers HGJ, Janssen E, Versteegh KLK, Buzink M, Nesheva D, Bosma R, de Esch IJP, ... ... Smit MJ, et al. Pharmacological characterization and radiolabeling of VUF15485, a high-affinity small-molecule agonist for the atypical chemokine receptor ACKR3. Molecular Pharmacology. PMID 38346795 DOI: 10.1124/molpharm.123.000835 |
0.707 |
|
| 2023 |
Bebelman MP, Setiawan IM, Bergkamp ND, van Senten JR, Crudden C, Bebelman JPM, Verweij FJ, van Niel G, Siderius M, Pegtel DM, Smit MJ. Exosomal release of the virus-encoded chemokine receptor US28 contributes to chemokine scavenging. Iscience. 26: 107412. PMID 37575190 DOI: 10.1016/j.isci.2023.107412 |
0.312 |
|
| 2023 |
van den Bor J, Bergkamp ND, Anbuhl SM, Dekker F, Comez D, Perez Almeria CV, Bosma R, White CW, Kilpatrick LE, Hill SJ, Siderius M, Smit MJ, Heukers R. NanoB to monitor interactions of ligands with membrane proteins by combining nanobodies and NanoBRET. Cell Reports Methods. 3: 100422. PMID 37056381 DOI: 10.1016/j.crmeth.2023.100422 |
0.423 |
|
| 2022 |
Paradis JS, Feng X, Murat B, Jefferson RE, Sokrat B, Szpakowska M, Hogue M, Bergkamp ND, Heydenreich FM, Smit MJ, Chevigné A, Bouvier M, Barth P. Computationally designed GPCR quaternary structures bias signaling pathway activation. Nature Communications. 13: 6826. PMID 36369272 DOI: 10.1038/s41467-022-34382-7 |
0.459 |
|
| 2022 |
Kleist AB, Jenjak S, Sente A, Laskowski LJ, Szpakowska M, Calkins MM, Anderson EI, McNally LM, Heukers R, Bobkov V, Peterson FC, Thomas MA, Chevigné A, Smit MJ, McCorvy JD, et al. Conformational selection guides β-arrestin recruitment at a biased G protein-coupled receptor. Science (New York, N.Y.). 377: 222-228. PMID 35857540 DOI: 10.1126/science.abj4922 |
0.301 |
|
| 2021 |
Song S, Liu B, Habibie H, van den Bor J, Smit MJ, Gosens R, Wu X, Brandsma CA, Cool RH, Haisma HJ, Poelarends GJ, Melgert BN. D-dopachrome tautomerase contributes to lung epithelial repair via atypical chemokine receptor 3-dependent Akt signaling. Ebiomedicine. 68: 103412. PMID 34098338 DOI: 10.1016/j.ebiom.2021.103412 |
0.318 |
|
| 2021 |
Zarca A, Perez C, van den Bor J, Bebelman JP, Heuninck J, de Jonker RJF, Durroux T, Vischer HF, Siderius M, Smit MJ. Differential Involvement of ACKR3 C-Tail in β-Arrestin Recruitment, Trafficking and Internalization. Cells. 10. PMID 33799570 DOI: 10.3390/cells10030618 |
0.314 |
|
| 2020 |
Işbilir A, Möller J, Arimont M, Bobkov V, Perpiñá-Viciano C, Hoffmann C, Inoue A, Heukers R, de Graaf C, Smit MJ, Annibale P, Lohse MJ. Advanced fluorescence microscopy reveals disruption of dynamic CXCR4 dimerization by subpocket-specific inverse agonists. Proceedings of the National Academy of Sciences of the United States of America. PMID 33148803 DOI: 10.1073/pnas.2013319117 |
0.449 |
|
| 2020 |
Smit MJ, Schlecht-Louf G, Neves M, den Bor JV, Penela P, Siderius M, Bachelerie F, Mayor F. The CXCL12/CXCR4/ACKR3 Axis in the Tumor Microenvironment: Signaling, Crosstalk, and Therapeutic Targeting. Annual Review of Pharmacology and Toxicology. PMID 32956018 DOI: 10.1146/Annurev-Pharmtox-010919-023340 |
0.393 |
|
| 2020 |
Daly CA, Smit MJ, Plouffe B. The constitutive activity of the viral-encoded G protein-coupled receptor US28 supports a complex signalling network contributing to cancer development. Biochemical Society Transactions. PMID 32779712 DOI: 10.1042/Bst20190988 |
0.506 |
|
| 2020 |
Bebelman MP, Crudden C, Pegtel DM, Smit MJ. The Convergence of Extracellular Vesicle and GPCR Biology. Trends in Pharmacological Sciences. PMID 32711926 DOI: 10.1016/J.Tips.2020.07.001 |
0.497 |
|
| 2020 |
Soave M, Heukers R, Kellam B, Woolard J, Smit MJ, Briddon SJ, Hill SJ. Monitoring Allosteric Interactions with CXCR4 Using NanoBiT Conjugated Nanobodies. Cell Chemical Biology. PMID 32610042 DOI: 10.1016/J.Chembiol.2020.06.006 |
0.489 |
|
| 2020 |
Perpina-Viciano C, Isbilir A, Zarca A, Caspar B, Kilpatrick LE, Hill SJ, Smit MJ, Lohse MJ, Hoffmann C. Kinetic analysis of the early signaling steps of the human chemokine receptor CXCR4. Molecular Pharmacology. PMID 32474443 DOI: 10.1124/Mol.119.118448 |
0.574 |
|
| 2020 |
van Senten JR, Fan TS, Siderius M, Smit MJ. Viral G protein-coupled receptors as modulators of cancer hallmarks. Pharmacological Research. 156: 104804. PMID 32278040 DOI: 10.1016/j.phrs.2020.104804 |
0.332 |
|
| 2019 |
Smit MJ, van Muilwijk-Koezen JE. From insight to modulation of CXCR4 and ACKR3 (CXCR7) function. Molecular Pharmacology. PMID 31624136 DOI: 10.1124/mol.119.118364 |
0.435 |
|
| 2019 |
van Senten JR, Bebelman MP, Fan TS, Heukers R, Bergkamp ND, van Gasselt P, Langemeijer EV, Slinger E, Lagerweij T, Rahbar A, Stigter-van Walsum M, Maussang D, Leurs R, Musters RJ, van Dongen GAMS, ... ... Smit MJ, et al. The human cytomegalovirus-encoded G protein-coupled receptor UL33 exhibits oncomodulatory properties. The Journal of Biological Chemistry. PMID 31519750 DOI: 10.1074/Jbc.Ra119.007796 |
0.733 |
|
| 2019 |
Bobkov V, Arimont M, Zarca A, De Groof T, van der Woning B, de Haard H, Smit MJ. Antibodies targeting chemokine receptors CXCR4 and ACKR3. Molecular Pharmacology. PMID 31481460 DOI: 10.1124/mol.119.116954 |
0.329 |
|
| 2019 |
De Groof TWM, Mashayekhi V, Fan TS, Bergkamp ND, Sastre Toraño J, van Senten JR, Heukers R, Smit MJ, Oliveira S. Nanobody-Targeted Photodynamic Therapy Selectively Kills Viral GPCR-Expressing Glioblastoma Cells. Molecular Pharmaceutics. PMID 31244224 DOI: 10.1021/Acs.Molpharmaceut.9B00360 |
0.384 |
|
| 2019 |
Heukers R, De Groof TWM, Smit MJ. Nanobodies detecting and modulating GPCRs outside in and inside out. Current Opinion in Cell Biology. 57: 115-122. PMID 30849632 DOI: 10.1016/J.Ceb.2019.01.003 |
0.447 |
|
| 2019 |
Fumagalli A, Zarca A, Neves M, Caspar B, Hill SJ, Mayor F, Smit MJ, Marin P. CXCR4/ACKR3 phosphorylation and recruitment of interacting proteins: key mechanisms regulating their functional status. Molecular Pharmacology. PMID 30837297 DOI: 10.1124/Mol.118.115360 |
0.373 |
|
| 2019 |
Neves M, Fumagalli A, van den Bor J, Marin P, Smit MJ, Mayor F. The role of ACKR3 in breast, lung and brain cancer. Molecular Pharmacology. PMID 30745320 DOI: 10.1124/Mol.118.115279 |
0.327 |
|
| 2019 |
De Groof TWM, Bobkov V, Heukers R, Smit MJ. Nanobodies: New avenues for imaging, stabilizing and modulating GPCRs. Molecular and Cellular Endocrinology. 484: 15-24. PMID 30690070 DOI: 10.1016/J.Mce.2019.01.021 |
0.399 |
|
| 2018 |
Adlere I, Sun S, Zarca A, Roumen L, Gozelle M, Viciano Perpiñá C, Caspar B, Arimont M, Bebelman JP, Briddon SJ, Hoffmann C, Hill SJ, Smit MJ, Vischer HF, Wijtmans M, et al. Structure-based exploration and pharmacological evaluation of N-substituted piperidin-4-yl-methanamine CXCR4 chemokine receptor antagonists. European Journal of Medicinal Chemistry. 162: 631-649. PMID 30476826 DOI: 10.1016/J.Ejmech.2018.10.060 |
0.696 |
|
| 2018 |
Van Hout A, Klarenbeek A, Bobkov V, Doijen J, Arimont M, Zhao C, Heukers R, Rimkunas R, de Graaf C, Verrips T, van der Woning B, de Haard H, Rucker JB, Vermeire K, Handel T, ... ... Smit MJ, et al. CXCR4-targeting nanobodies differentially inhibit CXCR4 function and HIV entry. Biochemical Pharmacology. PMID 30342024 DOI: 10.1016/J.Bcp.2018.10.015 |
0.391 |
|
| 2018 |
Bobkov V, Zarca AM, Van Hout A, Arimont M, Doijen J, Bialkowska M, Toffoli E, Klarenbeek A, van der Woning B, van der Vliet HJ, Van Loy T, de Haard H, Schols D, Heukers R, Smit MJ. Nanobody-Fc constructs targeting chemokine receptor CXCR4 potently inhibit signaling and CXCR4-mediated HIV-entry and induce antibody effector functions. Biochemical Pharmacology. PMID 30342023 DOI: 10.1016/J.Bcp.2018.10.014 |
0.431 |
|
| 2018 |
Heukers R, Fan TS, de Wit RH, van Senten JR, De Groof TWM, Bebelman MP, Lagerweij T, Vieira J, de Munnik SM, Smits-de Vries L, van Offenbeek J, Rahbar A, van Hoorick D, Söderberg-Naucler C, Würdinger T, ... ... Smit MJ, et al. The constitutive activity of the virally encoded chemokine receptor US28 accelerates glioblastoma growth. Oncogene. PMID 29706656 DOI: 10.1038/S41388-018-0255-7 |
0.675 |
|
| 2018 |
Hauwert NJ, Mocking TAM, Da Costa Pereira D, Kooistra AJ, Wijnen LM, Vreeker G, Verweij NWE, De Boer BH, Smit MJ, de Graaf C, Vischer HF, De Esch IJP, Wijtmans M, Leurs R. Synthesis and characterization of a bi-directional photoswitchable antagonist toolbox for real-time GPCR photopharmacology. Journal of the American Chemical Society. PMID 29470065 DOI: 10.1021/Jacs.7B11422 |
0.715 |
|
| 2018 |
Verweij FJ, Bebelman MP, Jimenez CR, Garcia-Vallejo JJ, Janssen H, Neefjes J, Knol JC, de Goeij-de Haas R, Piersma SR, Baglio SR, Verhage M, Middeldorp JM, Zomer A, van Rheenen J, Coppolino MG, ... ... Smit MJ, et al. Correction: Quantifying exosome secretion from single cells reveals a modulatory role for GPCR signaling. The Journal of Cell Biology. PMID 29362224 DOI: 10.1083/Jcb.20170320601192018C |
0.368 |
|
| 2018 |
Verweij FJ, Bebelman MP, Jimenez CR, Garcia-Vallejo JJ, Janssen H, Neefjes J, Knol JC, de Goeij-de Haas R, Piersma SR, Baglio SR, Verhage M, Middeldorp JM, Zomer A, van Rheenen J, Coppolino MG, ... ... Smit MJ, et al. Quantifying exosome secretion from single cells reveals a modulatory role for GPCR signaling. The Journal of Cell Biology. PMID 29339438 DOI: 10.1083/Jcb.201703206 |
0.343 |
|
| 2017 |
Krishna BA, Poole EL, Jackson SE, Smit MJ, Wills MR, Sinclair JH. Latency-Associated Expression of Human Cytomegalovirus US28 Attenuates Cell Signaling Pathways To Maintain Latent Infection. Mbio. 8. PMID 29208743 DOI: 10.1128/Mbio.01754-17 |
0.347 |
|
| 2017 |
de Wit RH, Heukers R, Brink H, Arsova A, Maussang D, Cutolo P, Strubbe B, Vischer H, Bachelerie F, Smit MJ. CXCR4-specific Nanobodies as potential therapeutics for WHIM syndrome. The Journal of Pharmacology and Experimental Therapeutics. PMID 28768817 DOI: 10.1124/Jpet.117.242735 |
0.434 |
|
| 2017 |
Ayoub MA, Crépieux P, Koglin M, Parmentier M, Pin JP, Poupon A, Reiter E, Smit M, Steyaert J, Watier H, Wilkinson T. Antibodies targeting G protein-coupled receptors: Recent advances and therapeutic challenges. Mabs. 0. PMID 28475474 DOI: 10.1080/19420862.2017.1325052 |
0.436 |
|
| 2017 |
Arimont M, Sun S, Leurs R, Smit M, De Esch IJ, de Graaf C. Structural Analysis of Chemokine Receptor-Ligand Interactions. Journal of Medicinal Chemistry. PMID 28165741 DOI: 10.1021/Acs.Jmedchem.6B01309 |
0.725 |
|
| 2016 |
de Wit RH, Mujić-Delić A, van Senten JR, Ramos AF, Siderius M, Smit MJ. Human cytomegalovirus encoded chemokine receptor US28 activates the HIF-1α/PKM2 axis in glioblastoma cells. Oncotarget. PMID 27602585 DOI: 10.18632/Oncotarget.11817 |
0.379 |
|
| 2016 |
Lollinga WT, de Wit RH, Rahbar A, Vasse GF, Davoudi B, Diepstra A, Riezebos-Brilman A, Harmsen MC, Hillebrands JL, Söderberg-Naucler C, van Son WJ, Smit MJ, Sanders JS, van den Born J. Human Cytomegalovirus-Encoded Receptor US28 Is Expressed in Renal Allografts and Facilitates Viral Spreading In Vitro. Transplantation. PMID 27362315 DOI: 10.1097/Tp.0000000000001289 |
0.384 |
|
| 2016 |
de Munnik SM, van der Lee R, Velders DM, van Offenbeek J, Smits-de Vries L, Leurs R, Smit MJ, Vischer HF. The viral G protein-coupled receptor ORF74 unmasks phospholipase C signaling of the receptor tyrosine kinase IGF-1R. Cellular Signalling. PMID 26931381 DOI: 10.1016/J.Cellsig.2016.02.017 |
0.701 |
|
| 2016 |
de Wit RH, de Munnik SM, Leurs R, Vischer HF, Smit MJ. Molecular Pharmacology of Chemokine Receptors. Methods in Enzymology. 570: 457-515. PMID 26921959 DOI: 10.1016/Bs.Mie.2015.12.002 |
0.733 |
|
| 2016 |
de Wit RH, de Munnik SM, Leurs R, Vischer HF, Smit MJ. Molecular Pharmacology of Chemokine Receptors Methods in Enzymology. DOI: 10.1016/bs.mie.2015.12.002 |
0.705 |
|
| 2015 |
Ganghammer S, Gutjahr J, Hutterer E, Krenn PW, Pucher S, Zelle-Rieser C, Jöhrer K, Wijtmans M, Leurs R, Smit MJ, Gattei V, Greil R, Hartmann TN. Combined CXCR3/CXCR4 measurements are of high prognostic value in chronic lymphocytic leukemia due to negative cooperativity of the receptors. Haematologica. PMID 26589908 DOI: 10.3324/Haematol.2015.133470 |
0.636 |
|
| 2015 |
Mladic M, Scholten DJ, Niessen WM, Somsen GW, Smit MJ, Kool J. At-line coupling of LC-MS to bioaffinity and selectivity assessment for metabolic profiling of ligands towards chemokine receptors CXCR1 and CXCR2. Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences. 1002: 42-53. PMID 26301479 DOI: 10.1016/J.Jchromb.2015.08.004 |
0.369 |
|
| 2015 |
Mladic M, Scholten DJ, Wijtmans M, Falck D, Leurs R, Niessen WM, Smit MJ, Kool J. Metabolic profiling of ligands for the chemokine receptor CXCR3 by liquid chromatography-mass spectrometry coupled to bioaffinity assessment. Analytical and Bioanalytical Chemistry. 407: 7067-81. PMID 26164305 DOI: 10.1007/S00216-015-8867-Z |
0.696 |
|
| 2015 |
Roth S, Kholodenko BN, Smit MJ, Bruggeman FJ. G Protein-Coupled Receptor Signaling Networks from a Systems Perspective. Molecular Pharmacology. 88: 604-16. PMID 26162865 DOI: 10.1124/Mol.115.100057 |
0.42 |
|
| 2015 |
Bohn LM, Lohse MJ, Nitabach M, Taghert PH, Smit MJ. Exploring the Biology of GPCRs from In Vitro to In Vivo. Molecular Pharmacology. PMID 26162863 DOI: 10.1124/Mol.115.100750 |
0.408 |
|
| 2015 |
Heo J, Dogra P, Masi TJ, Pitt EA, de Kruijf P, Smit MJ, Sparer TE. Novel Human Cytomegalovirus Viral Chemokines, vCXCL-1s, Display Functional Selectivity for Neutrophil Signaling and Function. Journal of Immunology (Baltimore, Md. : 1950). 195: 227-36. PMID 25987741 DOI: 10.4049/Jimmunol.1400291 |
0.468 |
|
| 2015 |
de Munnik SM, Kooistra AJ, van Offenbeek J, Nijmeijer S, de Graaf C, Smit MJ, Leurs R, Vischer HF. The Viral G Protein-Coupled Receptor ORF74 Hijacks β-Arrestins for Endocytic Trafficking in Response to Human Chemokines. Plos One. 10: e0124486. PMID 25894435 DOI: 10.1371/Journal.Pone.0124486 |
0.696 |
|
| 2015 |
de Munnik SM, Smit MJ, Leurs R, Vischer HF. Modulation of cellular signaling by herpesvirus-encoded G protein-coupled receptors. Frontiers in Pharmacology. 6: 40. PMID 25805993 DOI: 10.3389/Fphar.2015.00040 |
0.714 |
|
| 2015 |
Scholten DJ, Wijtmans M, van Senten JR, Custers H, Stunnenberg A, de Esch IJ, Smit MJ, Leurs R. Pharmacological characterization of [3H]VUF11211, a novel radiolabeled small-molecule inverse agonist for the chemokine receptor CXCR3. Molecular Pharmacology. 87: 639-48. PMID 25576486 DOI: 10.1124/Mol.114.095265 |
0.754 |
|
| 2015 |
Torraca V, Cui C, Boland R, Bebelman JP, van der Sar AM, Smit MJ, Siderius M, Spaink HP, Meijer AH. The CXCR3-CXCL11 signaling axis mediates macrophage recruitment and dissemination of mycobacterial infection. Disease Models & Mechanisms. 8: 253-69. PMID 25573892 DOI: 10.1242/Dmm.017756 |
0.404 |
|
| 2015 |
Maravillas-Montero JL, Burkhardt AM, Hevezi PA, Carnevale CD, Smit MJ, Zlotnik A. Cutting edge: GPR35/CXCR8 is the receptor of the mucosal chemokine CXCL17. Journal of Immunology (Baltimore, Md. : 1950). 194: 29-33. PMID 25411203 DOI: 10.4049/Jimmunol.1401704 |
0.554 |
|
| 2015 |
Wijtmans M, Scholten D, Mooij W, Smit MJ, De Esch IJP, De Graaf C, Leurs R. Exploring the cxcr3 chemokine receptor with small-molecule antagonists and agonists Topics in Medicinal Chemistry. 14: 119-186. DOI: 10.1007/7355_2014_75 |
0.698 |
|
| 2014 |
Richter R, Jochheim-Richter A, Ciuculescu F, Kollar K, Seifried E, Forssmann U, Verzijl D, Smit MJ, Blanchet X, von Hundelshausen P, Weber C, Forssmann WG, Henschler R. Identification and characterization of circulating variants of CXCL12 from human plasma: effects on chemotaxis and mobilization of hematopoietic stem and progenitor cells. Stem Cells and Development. 23: 1959-74. PMID 24708339 DOI: 10.1089/Scd.2013.0524 |
0.395 |
|
| 2014 |
Mujić-Delić A, de Wit RH, Verkaar F, Smit MJ. GPCR-targeting nanobodies: attractive research tools, diagnostics, and therapeutics. Trends in Pharmacological Sciences. 35: 247-55. PMID 24690241 DOI: 10.1016/J.Tips.2014.03.003 |
0.388 |
|
| 2014 |
Verkaar F, van Offenbeek J, van der Lee MM, van Lith LH, Watts AO, Rops AL, Aguilar DC, Ziarek JJ, van der Vlag J, Handel TM, Volkman BF, Proudfoot AE, Vischer HF, Zaman GJ, Smit MJ. Chemokine cooperativity is caused by competitive glycosaminoglycan binding. Journal of Immunology (Baltimore, Md. : 1950). 192: 3908-14. PMID 24639348 DOI: 10.4049/Jimmunol.1302159 |
0.482 |
|
| 2014 |
Vischer HF, Siderius M, Leurs R, Smit MJ. Herpesvirus-encoded GPCRs: neglected players in inflammatory and proliferative diseases? Nature Reviews. Drug Discovery. 13: 123-39. PMID 24445563 DOI: 10.1038/Nrd4189 |
0.726 |
|
| 2014 |
Scholten DJ, Roumen L, Wijtmans M, Verkade-Vreeker MC, Custers H, Lai M, de Hooge D, Canals M, de Esch IJ, Smit MJ, de Graaf C, Leurs R. Identification of overlapping but differential binding sites for the high-affinity CXCR3 antagonists NBI-74330 and VUF11211. Molecular Pharmacology. 85: 116-26. PMID 24174496 DOI: 10.1124/Mol.113.088633 |
0.692 |
|
| 2013 |
Maussang D, Muji?-Deli? A, Descamps FJ, Stortelers C, Vanlandschoot P, Stigter-van Walsum M, Vischer HF, van Roy M, Vosjan M, Gonzalez-Pajuelo M, van Dongen GA, Merchiers P, van Rompaey P, Smit MJ. Llama-derived single variable domains (nanobodies) directed against chemokine receptor CXCR7 reduce head and neck cancer cell growth in vivo. The Journal of Biological Chemistry. 288: 29562-72. PMID 23979133 DOI: 10.1074/Jbc.M113.498436 |
0.461 |
|
| 2013 |
Zweemer AJ, Nederpelt I, Vrieling H, Hafith S, Doornbos ML, de Vries H, Abt J, Gross R, Stamos D, Saunders J, Smit MJ, Ijzerman AP, Heitman LH. Multiple binding sites for small-molecule antagonists at the CC chemokine receptor 2. Molecular Pharmacology. 84: 551-61. PMID 23877010 DOI: 10.1124/Mol.113.086850 |
0.662 |
|
| 2013 |
Blanchetot C, Verzijl D, Mujić-Delić A, Bosch L, Rem L, Leurs R, Verrips CT, Saunders M, de Haard H, Smit MJ. Neutralizing nanobodies targeting diverse chemokines effectively inhibit chemokine function. The Journal of Biological Chemistry. 288: 25173-82. PMID 23836909 DOI: 10.1074/Jbc.M113.467969 |
0.716 |
|
| 2013 |
Watts AO, Verkaar F, van der Lee MM, Timmerman CA, Kuijer M, van Offenbeek J, van Lith LH, Smit MJ, Leurs R, Zaman GJ, Vischer HF. β-Arrestin recruitment and G protein signaling by the atypical human chemokine decoy receptor CCX-CKR. The Journal of Biological Chemistry. 288: 7169-81. PMID 23341447 DOI: 10.1074/Jbc.M112.406108 |
0.749 |
|
| 2013 |
Watts AO, van Lipzig MM, Jaeger WC, Seeber RM, van Zwam M, Vinet J, van der Lee MM, Siderius M, Zaman GJ, Boddeke HW, Smit MJ, Pfleger KD, Leurs R, Vischer HF. Identification and profiling of CXCR3-CXCR4 chemokine receptor heteromer complexes. British Journal of Pharmacology. 168: 1662-74. PMID 23170857 DOI: 10.1111/Bph.12064 |
0.738 |
|
| 2013 |
Vinet J, van Zwam M, Dijkstra IM, Brouwer N, van Weering HR, Watts A, Meijer M, Fokkens MR, Kannan V, Verzijl D, Vischer HF, Smit MJ, Leurs R, Biber K, Boddeke HW. Inhibition of CXCR3-mediated chemotaxis by the human chemokine receptor-like protein CCX-CKR. British Journal of Pharmacology. 168: 1375-87. PMID 23121557 DOI: 10.1111/Bph.12042 |
0.765 |
|
| 2012 |
Wijtmans M, Scholten DJ, Roumen L, Canals M, Custers H, Glas M, Vreeker MC, de Kanter FJ, de Graaf C, Smit MJ, de Esch IJ, Leurs R. Chemical subtleties in small-molecule modulation of peptide receptor function: the case of CXCR3 biaryl-type ligands. Journal of Medicinal Chemistry. 55: 10572-83. PMID 23150943 DOI: 10.1021/Jm301240T |
0.72 |
|
| 2012 |
Langemeijer EV, Slinger E, de Munnik S, Schreiber A, Maussang D, Vischer H, Verkaar F, Leurs R, Siderius M, Smit MJ. Constitutive β-catenin signaling by the viral chemokine receptor US28. Plos One. 7: e48935. PMID 23145028 DOI: 10.1371/Journal.Pone.0048935 |
0.7 |
|
| 2012 |
Bongers G, Muniz LR, Pacer ME, Iuga AC, Thirunarayanan N, Slinger E, Smit MJ, Reddy EP, Mayer L, Furtado GC, Harpaz N, Lira SA. A role for the epidermal growth factor receptor signaling in development of intestinal serrated polyps in mice and humans. Gastroenterology. 143: 730-40. PMID 22643351 DOI: 10.1053/J.Gastro.2012.05.034 |
0.378 |
|
| 2012 |
Canals M, Scholten DJ, de Munnik S, Han MK, Smit MJ, Leurs R. Ubiquitination of CXCR7 controls receptor trafficking. Plos One. 7: e34192. PMID 22457824 DOI: 10.1371/Journal.Pone.0034192 |
0.76 |
|
| 2012 |
Wijtmans M, Maussang D, Sirci F, Scholten DJ, Canals M, Mujić-Delić A, Chong M, Chatalic KL, Custers H, Janssen E, de Graaf C, Smit MJ, de Esch IJ, Leurs R. Synthesis, modeling and functional activity of substituted styrene-amides as small-molecule CXCR7 agonists. European Journal of Medicinal Chemistry. 51: 184-92. PMID 22424612 DOI: 10.1016/J.Ejmech.2012.02.041 |
0.721 |
|
| 2012 |
Dziurzynski K, Chang SM, Heimberger AB, Kalejta RF, McGregor Dallas SR, Smit M, Soroceanu L, Cobbs CS. Consensus on the role of human cytomegalovirus in glioblastoma. Neuro-Oncology. 14: 246-55. PMID 22319219 DOI: 10.1093/Neuonc/Nor227 |
0.308 |
|
| 2012 |
Zoughlami Y, Voermans C, Brussen K, van Dort KA, Kootstra NA, Maussang D, Smit MJ, Hordijk PL, van Hennik PB. Regulation of CXCR4 conformation by the small GTPase Rac1: implications for HIV infection. Blood. 119: 2024-32. PMID 22238325 DOI: 10.1182/Blood-2011-06-364828 |
0.437 |
|
| 2012 |
Scholten DJ, Canals M, Wijtmans M, de Munnik S, Nguyen P, Verzijl D, de Esch IJ, Vischer HF, Smit MJ, Leurs R. Pharmacological characterization of a small-molecule agonist for the chemokine receptor CXCR3. British Journal of Pharmacology. 166: 898-911. PMID 21883151 DOI: 10.1111/J.1476-5381.2011.01648.X |
0.773 |
|
| 2012 |
Koelink PJ, Overbeek SA, Braber S, de Kruijf P, Folkerts G, Smit MJ, Kraneveld AD. Targeting chemokine receptors in chronic inflammatory diseases: an extensive review. Pharmacology & Therapeutics. 133: 1-18. PMID 21839114 DOI: 10.1016/J.Pharmthera.2011.06.008 |
0.434 |
|
| 2012 |
Scholten DJ, Canals M, Maussang D, Roumen L, Smit MJ, Wijtmans M, de Graaf C, Vischer HF, Leurs R. Pharmacological modulation of chemokine receptor function. British Journal of Pharmacology. 165: 1617-43. PMID 21699506 DOI: 10.1111/J.1476-5381.2011.01551.X |
0.739 |
|
| 2012 |
Langemeijer EV, Slinger E, Munnik Sd, Schreiber A, Maussang D, Vischer H, Verkaar F, Leurs R, Siderius M, Smit MJ. Schematic representation of the classic Wnt signaling pathway and model of US28-mediated activation of ß-catenin signaling pathway. Plos One. DOI: 10.1371/Journal.Pone.0048935.G005 |
0.595 |
|
| 2012 |
Smit MJ. Targeting the chemokine receptor system Drug Discovery Today: Technologies. 9: e227-e228. DOI: 10.1016/J.Ddtec.2012.09.006 |
0.491 |
|
| 2012 |
Siderius M, Wal M, Scholten DJ, Smit MJ, Sakmar TP, Leurs R, De Graaf C. Unnatural amino acids for the study of chemokine receptor structure and dynamics Drug Discovery Today: Technologies. 9: e301-e313. DOI: 10.1016/J.Ddtec.2012.07.008 |
0.737 |
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| 2012 |
Klarenbeek A, Maussang D, Blanchetot C, Saunders M, Van Der Woning S, Smit M, De Haard H, Hofman E. Targeting chemokines and chemokine receptors with antibodies Drug Discovery Today: Technologies. 9: e237-e244. DOI: 10.1016/J.Ddtec.2012.05.003 |
0.36 |
|
| 2012 |
Wijtmans M, Scholten DJ, De Esch IJP, Smit MJ, Leurs R. Therapeutic targeting of chemokine receptors by small molecules Drug Discovery Today: Technologies. 9: e229-e236. DOI: 10.1016/J.Ddtec.2012.03.004 |
0.71 |
|
| 2011 |
de Kruijf P, Lim HD, Roumen L, Renjaän VA, Zhao J, Webb ML, Auld DS, Wijkmans JC, Zaman GJ, Smit MJ, de Graaf C, Leurs R. Identification of a novel allosteric binding site in the CXCR2 chemokine receptor. Molecular Pharmacology. 80: 1108-18. PMID 21948388 DOI: 10.1124/Mol.111.073825 |
0.74 |
|
| 2011 |
Wijtmans M, Verzijl D, Bergmans S, Lai M, Bosch L, Smit MJ, de Esch IJ, Leurs R. CXCR3 antagonists: quaternary ammonium salts equipped with biphenyl- and polycycloaliphatic-anchors. Bioorganic & Medicinal Chemistry. 19: 3384-93. PMID 21570852 DOI: 10.1016/J.Bmc.2011.04.035 |
0.684 |
|
| 2011 |
Overbeek SA, Henricks PA, Srienc AI, Koelink PJ, de Kruijf P, Lim HD, Smit MJ, Zaman GJ, Garssen J, Nijkamp FP, Kraneveld AD, Folkerts G. N-acetylated Proline-Glycine-Proline induced G-protein dependent chemotaxis of neutrophils is independent of CXCL8 release. European Journal of Pharmacology. 668: 428-34. PMID 21458443 DOI: 10.1016/J.Ejphar.2011.03.022 |
0.331 |
|
| 2011 |
Qin Y, Verdegaal EM, Siderius M, Bebelman JP, Smit MJ, Leurs R, Willemze R, Tensen CP, Osanto S. Quantitative expression profiling of G-protein-coupled receptors (GPCRs) in metastatic melanoma: the constitutively active orphan GPCR GPR18 as novel drug target. Pigment Cell & Melanoma Research. 24: 207-18. PMID 20880198 DOI: 10.1111/J.1755-148X.2010.00781.X |
0.731 |
|
| 2011 |
Slinger E, Langemeijer E, Siderius M, Vischer HF, Smit MJ. Herpesvirus-encoded GPCRs rewire cellular signaling. Molecular and Cellular Endocrinology. 331: 179-84. PMID 20398729 DOI: 10.1016/J.Mce.2010.04.007 |
0.43 |
|
| 2010 |
Jähnichen S, Blanchetot C, Maussang D, Gonzalez-Pajuelo M, Chow KY, Bosch L, De Vrieze S, Serruys B, Ulrichts H, Vandevelde W, Saunders M, De Haard HJ, Schols D, Leurs R, Vanlandschoot P, ... ... Smit MJ, et al. CXCR4 nanobodies (VHH-based single variable domains) potently inhibit chemotaxis and HIV-1 replication and mobilize stem cells. Proceedings of the National Academy of Sciences of the United States of America. 107: 20565-70. PMID 21059953 DOI: 10.1073/Pnas.1012865107 |
0.706 |
|
| 2010 |
Bongers G, Maussang D, Muniz LR, Noriega VM, Fraile-Ramos A, Barker N, Marchesi F, Thirunarayanan N, Vischer HF, Qin L, Mayer L, Harpaz N, Leurs R, Furtado GC, Clevers H, ... ... Smit MJ, et al. The cytomegalovirus-encoded chemokine receptor US28 promotes intestinal neoplasia in transgenic mice. The Journal of Clinical Investigation. 120: 3969-78. PMID 20978345 DOI: 10.1172/Jci42563 |
0.641 |
|
| 2010 |
Slinger E, Maussang D, Schreiber A, Siderius M, Rahbar A, Fraile-Ramos A, Lira SA, Söderberg-Nauclér C, Smit MJ. HCMV-encoded chemokine receptor US28 mediates proliferative signaling through the IL-6-STAT3 axis. Science Signaling. 3: ra58. PMID 20682912 DOI: 10.1126/Scisignal.2001180 |
0.354 |
|
| 2010 |
Nijmeijer S, Leurs R, Smit MJ, Vischer HF. The Epstein-Barr virus-encoded G protein-coupled receptor BILF1 hetero-oligomerizes with human CXCR4, scavenges Gαi proteins, and constitutively impairs CXCR4 functioning. The Journal of Biological Chemistry. 285: 29632-41. PMID 20622011 DOI: 10.1074/Jbc.M110.115618 |
0.753 |
|
| 2010 |
de Kruijf P, Lim HD, Overbeek SA, Zaman GJ, Kraneveld AD, Folkerts G, Leurs R, Smit MJ. The collagen-breakdown product N-acetyl-Proline-Glycine-Proline (N-alpha-PGP) does not interact directly with human CXCR1 and CXCR2. European Journal of Pharmacology. 643: 29-33. PMID 20599927 DOI: 10.1016/J.Ejphar.2010.06.017 |
0.636 |
|
| 2010 |
Tschische P, Moser E, Thompson D, Vischer HF, Parzmair GP, Pommer V, Platzer W, Schwarzbraun T, Schaider H, Smit MJ, Martini L, Whistler JL, Waldhoer M. The G-protein coupled receptor associated sorting protein GASP-1 regulates the signalling and trafficking of the viral chemokine receptor US28. Traffic (Copenhagen, Denmark). 11: 660-74. PMID 20102549 DOI: 10.1111/J.1600-0854.2010.01045.X |
0.494 |
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| 2010 |
Vischer HF, Hulshof JW, Hulscher S, Fratantoni SA, Verheij MH, Victorina J, Smit MJ, de Esch IJ, Leurs R. Identification of novel allosteric nonpeptidergic inhibitors of the human cytomegalovirus-encoded chemokine receptor US28. Bioorganic & Medicinal Chemistry. 18: 675-88. PMID 20031418 DOI: 10.1016/J.Bmc.2009.11.060 |
0.719 |
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| 2009 |
Maussang D, Vischer HF, Leurs R, Smit MJ. Herpesvirus-encoded G protein-coupled receptors as modulators of cellular function. Molecular Pharmacology. 76: 692-701. PMID 19570946 DOI: 10.1124/Mol.109.057091 |
0.757 |
|
| 2009 |
Richter R, Casarosa P, Ständker L, Münch J, Springael JY, Nijmeijer S, Forssmann WG, Vischer HF, Vakili J, Detheux M, Parmentier M, Leurs R, Smit MJ. Significance of N-terminal proteolysis of CCL14a to activity on the chemokine receptors CCR1 and CCR5 and the human cytomegalovirus-encoded chemokine receptor US28. Journal of Immunology (Baltimore, Md. : 1950). 183: 1229-37. PMID 19553544 DOI: 10.4049/Jimmunol.0802145 |
0.745 |
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| 2009 |
Maussang D, Vischer HF, Schreiber A, Michel D, Smit MJ. Pharmacological and biochemical characterization of human cytomegalovirus-encoded G protein-coupled receptors. Methods in Enzymology. 460: 151-71. PMID 19446724 DOI: 10.1016/S0076-6879(09)05207-0 |
0.485 |
|
| 2009 |
Maussang D, Langemeijer E, Fitzsimons CP, Stigter-van Walsum M, Dijkman R, Borg MK, Slinger E, Schreiber A, Michel D, Tensen CP, van Dongen GA, Leurs R, Smit MJ. The human cytomegalovirus-encoded chemokine receptor US28 promotes angiogenesis and tumor formation via cyclooxygenase-2. Cancer Research. 69: 2861-9. PMID 19318580 DOI: 10.1158/0008-5472.Can-08-2487 |
0.66 |
|
| 2009 |
Wijtmans M, Verzijl D, van Dam CM, Bosch L, Smit MJ, Leurs R, de Esch IJ. Exploring a pocket for polycycloaliphatic groups in the CXCR3 receptor with the aid of a modular synthetic strategy. Bioorganic & Medicinal Chemistry Letters. 19: 2252-7. PMID 19299127 DOI: 10.1016/J.Bmcl.2009.02.093 |
0.667 |
|
| 2009 |
Vomaske J, Melnychuk RM, Smith PP, Powell J, Hall L, DeFilippis V, Früh K, Smit M, Schlaepfer DD, Nelson JA, Streblow DN. Differential ligand binding to a human cytomegalovirus chemokine receptor determines cell type-specific motility. Plos Pathogens. 5: e1000304. PMID 19229316 DOI: 10.1371/Journal.Ppat.1000304 |
0.498 |
|
| 2009 |
de Kruijf P, van Heteren J, Lim HD, Conti PG, van der Lee MM, Bosch L, Ho KK, Auld D, Ohlmeyer M, Smit MJ, Wijkmans JC, Zaman GJ, Smit MJ, Leurs R. Nonpeptidergic allosteric antagonists differentially bind to the CXCR2 chemokine receptor. The Journal of Pharmacology and Experimental Therapeutics. 329: 783-90. PMID 19190236 DOI: 10.1124/Jpet.108.148387 |
0.712 |
|
| 2009 |
Tschische P, Moser E, Thompson D, Platzer W, Vischer H, Smit MJ, Schaider H, Martini L, Whistler J, Waldhoer M. The sorting protein GASP-1 regulates the constitutive signaling capacity of the virally encoded chemokine receptor US28 Bmc Pharmacology. 9: A4. DOI: 10.1186/1471-2210-9-S2-A4 |
0.323 |
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| 2008 |
Vischer HF, Nijmeijer S, Smit MJ, Leurs R. Viral hijacking of human receptors through heterodimerization. Biochemical and Biophysical Research Communications. 377: 93-7. PMID 18823943 DOI: 10.1016/J.Bbrc.2008.09.082 |
0.719 |
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| 2008 |
van Koppen CJ, Zaman GJ, Timmers CM, Kelder J, Mosselman S, van de Lagemaat R, Smit MJ, Hanssen RG. A signaling-selective, nanomolar potent allosteric low molecular weight agonist for the human luteinizing hormone receptor. Naunyn-Schmiedeberg's Archives of Pharmacology. 378: 503-14. PMID 18551279 DOI: 10.1007/s00210-008-0318-3 |
0.352 |
|
| 2008 |
van Rijn RM, van Marle A, Chazot PL, Langemeijer E, Qin Y, Shenton FC, Lim HD, Zuiderveld OP, Sansuk K, Dy M, Smit MJ, Tensen CP, Bakker RA, Leurs R. Cloning and characterization of dominant negative splice variants of the human histamine H4 receptor. The Biochemical Journal. 414: 121-31. PMID 18452403 DOI: 10.1042/Bj20071583 |
0.791 |
|
| 2008 |
Wijtmans M, Verzijl D, Leurs R, de Esch IJ, Smit MJ. Towards small-molecule CXCR3 ligands with clinical potential. Chemmedchem. 3: 861-72. PMID 18442035 DOI: 10.1002/cmdc.200700365 |
0.631 |
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| 2008 |
Catusse J, Spinks J, Mattick C, Dyer A, Laing K, Fitzsimons C, Smit MJ, Gompels UA. Immunomodulation by herpesvirus U51A chemokine receptor via CCL5 and FOG-2 down-regulation plus XCR1 and CCR7 mimicry in human leukocytes. European Journal of Immunology. 38: 763-77. PMID 18286574 DOI: 10.1002/Eji.200737618 |
0.476 |
|
| 2008 |
Verzijl D, Storelli S, Scholten DJ, Bosch L, Reinhart TA, Streblow DN, Tensen CP, Fitzsimons CP, Zaman GJ, Pease JE, de Esch IJ, Smit MJ, Leurs R. Noncompetitive antagonism and inverse agonism as mechanism of action of nonpeptidergic antagonists at primate and rodent CXCR3 chemokine receptors. The Journal of Pharmacology and Experimental Therapeutics. 325: 544-55. PMID 18270317 DOI: 10.1124/Jpet.107.134783 |
0.687 |
|
| 2008 |
Rosenkilde MM, Smit MJ, Waldhoer M. Structure, function and physiological consequences of virally encoded chemokine seven transmembrane receptors. British Journal of Pharmacology. 153: S154-66. PMID 18204488 DOI: 10.1038/Sj.Bjp.0707660 |
0.538 |
|
| 2008 |
Parzmair GP, Platzer W, Vischer HF, Smit MJ, Waldhoer M. The far carboxy-terminus of the viral encoded chemokine receptor US28 binds to the sorting protein GASP-1 in vitro Bmc Pharmacology. 8: A26. DOI: 10.1186/1471-2210-8-S1-A26 |
0.543 |
|
| 2007 |
Storelli S, Verzijl D, Al-Badie J, Elders N, Bosch L, Timmerman H, Smit MJ, De Esch IJ, Leurs R. Synthesis and structure-activity relationships of 3H-quinazolin-4-ones and 3H-pyrido[2,3-d]pyrimidin-4-ones as CXCR3 receptor antagonists. Archiv Der Pharmazie. 340: 281-91. PMID 17562560 DOI: 10.1002/Ardp.200700037 |
0.824 |
|
| 2007 |
Hulsman N, Medema JP, Bos C, Jongejan A, Leurs R, Smit MJ, de Esch IJ, Richel D, Wijtmans M. Chemical insights in the concept of hybrid drugs: the antitumor effect of nitric oxide-donating aspirin involves a quinone methide but not nitric oxide nor aspirin. Journal of Medicinal Chemistry. 50: 2424-31. PMID 17441704 DOI: 10.1021/Jm061371E |
0.578 |
|
| 2007 |
Smit MJ, Vischer HF, Bakker RA, Jongejan A, Timmerman H, Pardo L, Leurs R. Pharmacogenomic and structural analysis of constitutive g protein-coupled receptor activity. Annual Review of Pharmacology and Toxicology. 47: 53-87. PMID 17029567 DOI: 10.1146/Annurev.Pharmtox.47.120505.105126 |
0.811 |
|
| 2006 |
Vischer HF, Hulshof JW, de Esch IJ, Smit MJ, Leurs R. Virus-encoded G-protein-coupled receptors: constitutively active (dys)regulators of cell function and their potential as drug target. Ernst Schering Foundation Symposium Proceedings. 187-209. PMID 17703583 |
0.686 |
|
| 2006 |
Verzijl D, Pardo L, van Dijk M, Gruijthuijsen YK, Jongejan A, Timmerman H, Nicholas J, Schwarz M, Murphy PM, Leurs R, Smit MJ. Helix 8 of the viral chemokine receptor ORF74 directs chemokine binding. The Journal of Biological Chemistry. 281: 35327-35. PMID 16997914 DOI: 10.1074/Jbc.M606877200 |
0.812 |
|
| 2006 |
Maussang D, Verzijl D, van Walsum M, Leurs R, Holl J, Pleskoff O, Michel D, van Dongen GA, Smit MJ. Human cytomegalovirus-encoded chemokine receptor US28 promotes tumorigenesis. Proceedings of the National Academy of Sciences of the United States of America. 103: 13068-73. PMID 16924106 DOI: 10.1073/Pnas.0604433103 |
0.701 |
|
| 2006 |
Hulshof JW, Vischer HF, Verheij MH, Fratantoni SA, Smit MJ, de Esch IJ, Leurs R. Synthesis and pharmacological characterization of novel inverse agonists acting on the viral-encoded chemokine receptor US28. Bioorganic & Medicinal Chemistry. 14: 7213-30. PMID 16843661 DOI: 10.1016/J.Bmc.2006.06.054 |
0.735 |
|
| 2006 |
Vischer HF, Vink C, Smit MJ. A viral conspiracy: hijacking the chemokine system through virally encoded pirated chemokine receptors. Current Topics in Microbiology and Immunology. 303: 121-54. PMID 16570859 DOI: 10.1007/978-3-540-33397-5_6 |
0.52 |
|
| 2006 |
Ho KK, Auld DS, Bohnstedt AC, Conti P, Dokter W, Erickson S, Feng D, Inglese J, Kingsbury C, Kultgen SG, Liu RQ, Masterson CM, Ohlmeyer M, Rong Y, Rooseboom M, ... ... Smit MJ, et al. Imidazolylpyrimidine based CXCR2 chemokine receptor antagonists. Bioorganic & Medicinal Chemistry Letters. 16: 2724-8. PMID 16540318 DOI: 10.1016/j.bmcl.2006.02.028 |
0.358 |
|
| 2006 |
van Cleef KW, Smit MJ, Bruggeman CA, Vink C. Cytomegalovirus-encoded homologs of G protein-coupled receptors and chemokines. Journal of Clinical Virology : the Official Publication of the Pan American Society For Clinical Virology. 35: 343-8. PMID 16406796 DOI: 10.1016/J.Jcv.2005.10.013 |
0.432 |
|
| 2006 |
Vischer HF, Leurs R, Smit MJ. HCMV-encoded G-protein-coupled receptors as constitutively active modulators of cellular signaling networks. Trends in Pharmacological Sciences. 27: 56-63. PMID 16352349 DOI: 10.1016/J.Tips.2005.11.006 |
0.748 |
|
| 2006 |
Fitzsimons CP, Gompels UA, Verzijl D, Vischer HF, Mattick C, Leurs R, Smit MJ. Chemokine-directed trafficking of receptor stimulus to different g proteins: selective inducible and constitutive signaling by human herpesvirus 6-encoded chemokine receptor U51. Molecular Pharmacology. 69: 888-98. PMID 16332987 DOI: 10.1124/Mol.105.015222 |
0.724 |
|
| 2005 |
Hulshof JW, Casarosa P, Menge WM, Kuusisto LM, van der Goot H, Smit MJ, de Esch IJ, Leurs R. Synthesis and structure-activity relationship of the first nonpeptidergic inverse agonists for the human cytomegalovirus encoded chemokine receptor US28. Journal of Medicinal Chemistry. 48: 6461-71. PMID 16190772 DOI: 10.1021/Jm050418D |
0.739 |
|
| 2005 |
Pleskoff O, Casarosa P, Verneuil L, Ainoun F, Beisser P, Smit M, Leurs R, Schneider P, Michelson S, Ameisen JC. The human cytomegalovirus-encoded chemokine receptor US28 induces caspase-dependent apoptosis. The Febs Journal. 272: 4163-77. PMID 16098198 DOI: 10.1111/J.1742-4658.2005.04829.X |
0.69 |
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| 2005 |
Mihara K, Smit MJ, Krajnc-Franken M, Gossen J, Rooseboom M, Dokter W. Human CXCR2 (hCXCR2) takes over functionalities of its murine homolog in hCXCR2 knockin mice. European Journal of Immunology. 35: 2573-82. PMID 16094689 DOI: 10.1002/eji.200526021 |
0.315 |
|
| 2005 |
Storelli S, Verdijk P, Verzijl D, Timmerman H, van de Stolpe AC, Tensen CP, Smit MJ, De Esch IJ, Leurs R. Synthesis and structure-activity relationship of 3-phenyl-3H-quinazolin-4-one derivatives as CXCR3 chemokine receptor antagonists. Bioorganic & Medicinal Chemistry Letters. 15: 2910-3. PMID 15911279 DOI: 10.1016/J.Bmcl.2005.03.070 |
0.824 |
|
| 2005 |
Beisser PS, Verzijl D, Gruijthuijsen YK, Beuken E, Smit MJ, Leurs R, Bruggeman CA, Vink C. The Epstein-Barr virus BILF1 gene encodes a G protein-coupled receptor that inhibits phosphorylation of RNA-dependent protein kinase. Journal of Virology. 79: 441-9. PMID 15596837 DOI: 10.1128/Jvi.79.1.441-449.2005 |
0.679 |
|
| 2005 |
Casarosa P, Waldhoer M, LiWang PJ, Vischer HF, Kledal T, Timmerman H, Schwartz TW, Smit MJ, Leurs R. CC and CX3C chemokines differentially interact with the N terminus of the human cytomegalovirus-encoded US28 receptor. The Journal of Biological Chemistry. 280: 3275-85. PMID 15546882 DOI: 10.1074/Jbc.M407536200 |
0.819 |
|
| 2004 |
Gruijthuijsen YK, Beuken EV, Smit MJ, Leurs R, Bruggeman CA, Vink C. Mutational analysis of the R33-encoded G protein-coupled receptor of rat cytomegalovirus: identification of amino acid residues critical for cellular localization and ligand-independent signalling. The Journal of General Virology. 85: 897-909. PMID 15039532 DOI: 10.1099/Vir.0.19709-0 |
0.71 |
|
| 2004 |
Verzijl D, Fitzsimons CP, Van Dijk M, Stewart JP, Timmerman H, Smit MJ, Leurs R. Differential activation of murine herpesvirus 68- and Kaposi's sarcoma-associated herpesvirus-encoded ORF74 G protein-coupled receptors by human and murine chemokines. Journal of Virology. 78: 3343-51. PMID 15016856 DOI: 10.1128/Jvi.78.7.3343-3351.2004 |
0.812 |
|
| 2004 |
Hensbergen PJ, Verzijl D, Balog CI, Dijkman R, van der Schors RC, van der Raaij-Helmer EM, van der Plas MJ, Leurs R, Deelder AM, Smit MJ, Tensen CP. Furin is a chemokine-modifying enzyme: in vitro and in vivo processing of CXCL10 generates a C-terminally truncated chemokine retaining full activity. The Journal of Biological Chemistry. 279: 13402-11. PMID 14739277 DOI: 10.1074/Jbc.M312814200 |
0.671 |
|
| 2004 |
Bakker RA, Casarosa P, Timmerman H, Smit MJ, Leurs R. Constitutively active Gq/11-coupled receptors enable signaling by co-expressed G(i/o)-coupled receptors. The Journal of Biological Chemistry. 279: 5152-61. PMID 14610092 DOI: 10.1074/Jbc.M309200200 |
0.811 |
|
| 2003 |
Govoni M, Bakker RA, van de Wetering I, Smit MJ, Menge WM, Timmerman H, Elz S, Schunack W, Leurs R. Synthesis and pharmacological identification of neutral histamine H1-receptor antagonists. Journal of Medicinal Chemistry. 46: 5812-24. PMID 14667234 DOI: 10.1021/Jm030936T |
0.806 |
|
| 2003 |
Casarosa P, Gruijthuijsen YK, Michel D, Beisser PS, Holl J, Fitzsimons CP, Verzijl D, Bruggeman CA, Mertens T, Leurs R, Vink C, Smit MJ. Constitutive signaling of the human cytomegalovirus-encoded receptor UL33 differs from that of its rat cytomegalovirus homolog R33 by promiscuous activation of G proteins of the Gq, Gi, and Gs classes. The Journal of Biological Chemistry. 278: 50010-23. PMID 14522997 DOI: 10.1074/jbc.M306530200 |
0.668 |
|
| 2003 |
Streblow DN, Vomaske J, Smith P, Melnychuk R, Hall L, Pancheva D, Smit M, Casarosa P, Schlaepfer DD, Nelson JA. Human Cytomegalovirus Chemokine Receptor US28-induced Smooth Muscle Cell Migration is Mediated by Focal Adhesion Kinase and Src Journal of Biological Chemistry. 278: 50456-50465. PMID 14506272 DOI: 10.1074/Jbc.M307936200 |
0.416 |
|
| 2003 |
Hashimoto T, Harusawa S, Araki L, Zuiderveld OP, Smit MJ, Imazu T, Takashima S, Yamamoto Y, Sakamoto Y, Kurihara T, Leurs R, Bakker RA, Yamatodani A. A selective human H(4)-receptor agonist: (-)-2-cyano-1-methyl-3-[(2R,5R)-5- [1H-imidazol-4(5)-yl]tetrahydrofuran-2-y] methylguanidine. Journal of Medicinal Chemistry. 46: 3162-5. PMID 12825954 DOI: 10.1021/Jm0300025 |
0.73 |
|
| 2003 |
Smit MJ, Vink C, Verzijl D, Casarosa P, Bruggeman CA, Leurs R. Virally encoded G protein-coupled receptors: targets for potentially innovative anti-viral drug development. Current Drug Targets. 4: 431-41. PMID 12816350 |
0.7 |
|
| 2003 |
Smit MJ, Verdijk P, van der Raaij-Helmer EM, Navis M, Hensbergen PJ, Leurs R, Tensen CP. CXCR3-mediated chemotaxis of human T cells is regulated by a Gi- and phospholipase C-dependent pathway and not via activation of MEK/p44/p42 MAPK nor Akt/PI-3 kinase. Blood. 102: 1959-65. PMID 12750173 DOI: 10.1182/Blood-2002-12-3945 |
0.663 |
|
| 2003 |
Waldhoer M, Casarosa P, Rosenkilde MM, Smit MJ, Leurs R, Whistler JL, Schwartz TW. The carboxyl terminus of human cytomegalovirus-encoded 7 transmembrane receptor US28 camouflages agonism by mediating constitutive endocytosis. The Journal of Biological Chemistry. 278: 19473-82. PMID 12646575 DOI: 10.1074/Jbc.M213179200 |
0.735 |
|
| 2003 |
Casarosa P, Menge WM, Minisini R, Otto C, van Heteren J, Jongejan A, Timmerman H, Moepps B, Kirchhoff F, Mertens T, Smit MJ, Leurs R. Identification of the first nonpeptidergic inverse agonist for a constitutively active viral-encoded G protein-coupled receptor. The Journal of Biological Chemistry. 278: 5172-8. PMID 12456673 DOI: 10.1074/Jbc.M210033200 |
0.826 |
|
| 2003 |
Leurs R, Bakker RA, Casarosa P, Verzijl D, Timmerman H, Smit MJ. Modulation of constitutive GPCR activity: a way of life? International Congress Series. 1249: 131-138. DOI: 10.1016/S0531-5131(03)00608-3 |
0.563 |
|
| 2002 |
Santore TA, Chen Y, Smit MJ, Iyengar R. Adenovirus-directed expression of Q227L-G alpha(s) inhibits growth of established tumors of later-stage human breast cancer cells in athymic mice. Proceedings of the National Academy of Sciences of the United States of America. 99: 1671-6. PMID 11805301 DOI: 10.1073/Pnas.032661999 |
0.306 |
|
| 2002 |
Smit MJ, Verzijl D, Casarosa P, Navis M, Timmerman H, Leurs R. Kaposi's sarcoma-associated herpesvirus-encoded G protein-coupled receptor ORF74 constitutively activates p44/p42 MAPK and Akt via G(i) and phospholipase C-dependent signaling pathways. Journal of Virology. 76: 1744-52. PMID 11799169 DOI: 10.1128/Jvi.76.4.1744-1752.2002 |
0.77 |
|
| 2002 |
Gruijthuijsen YK, Casarosa P, Kaptein SJ, Broers JL, Leurs R, Bruggeman CA, Smit MJ, Vink C. The rat cytomegalovirus R33-encoded G protein-coupled receptor signals in a constitutive fashion. Journal of Virology. 76: 1328-38. PMID 11773407 DOI: 10.1128/Jvi.76.3.1328-1338.2002 |
0.692 |
|
| 2002 |
Smit MJ, Bakker RA, Burstein ES. G protein-coupled receptors and proliferative signaling. Methods in Enzymology. 343: 430-47. PMID 11665583 DOI: 10.1016/S0076-6879(02)43150-3 |
0.493 |
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| 2002 |
Leurs R, Hoffmann M, Alewijnse AE, Smit MJ, Timmerman H. Methods to determine the constitutive activity of histamine H2 receptors. Methods in Enzymology. 343: 405-16. PMID 11665581 DOI: 10.1016/S0076-6879(02)43148-5 |
0.836 |
|
| 2001 |
Bakker RA, Schoonus SB, Smit MJ, Timmerman H, Leurs R. Histamine H(1)-receptor activation of nuclear factor-kappa B: roles for G beta gamma- and G alpha(q/11)-subunits in constitutive and agonist-mediated signaling. Molecular Pharmacology. 60: 1133-42. PMID 11641442 DOI: 10.1124/Mol.60.5.1133 |
0.787 |
|
| 2001 |
Vink C, Smit MJ, Leurs R, Bruggeman CA. The role of cytomegalovirus-encoded homologs of G protein-coupled receptors and chemokines in manipulation of and evasion from the immune system. Journal of Clinical Virology : the Official Publication of the Pan American Society For Clinical Virology. 23: 43-55. PMID 11595583 DOI: 10.1016/S1386-6532(01)00184-6 |
0.666 |
|
| 2001 |
Drutel G, Peitsaro N, Karlstedt K, Wieland K, Smit MJ, Timmerman H, Panula P, Leurs R. Identification of rat H3 receptor isoforms with different brain expression and signaling properties. Molecular Pharmacology. 59: 1-8. PMID 11125017 DOI: 10.1124/Mol.59.1.1 |
0.835 |
|
| 2001 |
Casarosa P, Bakker RA, Verzijl D, Navis M, Timmerman H, Leurs R, Smit MJ. Constitutive signaling of the human cytomegalovirus-encoded chemokine receptor US28. The Journal of Biological Chemistry. 276: 1133-7. PMID 11050102 DOI: 10.1074/Jbc.M008965200 |
0.818 |
|
| 2000 |
Smit MJ, Timmerman H, Verzijl D, Leurs R. Viral-encoded G-protein coupled receptors: new targets for drug research? Pharmaceutica Acta Helvetiae. 74: 299-304. PMID 10812973 DOI: 10.1016/S0031-6865(99)00039-4 |
0.771 |
|
| 2000 |
Alewijnse AE, Timmerman H, Jacobs EH, Smit MJ, Roovers E, Cotecchia S, Leurs R. The effect of mutations in the DRY motif on the constitutive activity and structural instability of the histamine H(2) receptor. Molecular Pharmacology. 57: 890-8. PMID 10779371 |
0.761 |
|
| 1999 |
Wieland K, Laak AM, Smit MJ, Kühne R, Timmerman H, Leurs R. Mutational analysis of the antagonist-binding site of the histamine H(1) receptor. The Journal of Biological Chemistry. 274: 29994-30000. PMID 10514483 DOI: 10.1074/Jbc.274.42.29994 |
0.803 |
|
| 1999 |
Smit MJ, Hoffmann M, Timmerman H, Leurs R. Molecular properties and signalling pathways of the histamine H1 receptor. Clinical and Experimental Allergy : Journal of the British Society For Allergy and Clinical Immunology. 29: 19-28. PMID 10444208 |
0.823 |
|
| 1999 |
Smit MJ, Hoffmann M, Timmerman H, Leurs R. Molecular properties and signalling pathways of the histamine H1
receptor Clinical & Experimental Allergy. 29: 19-28. DOI: 10.1046/J.1365-2222.1999.00007.X-I1 |
0.832 |
|
| 1998 |
Leurs R, Smit MJ, Alewijnse AE, Timmerman H. Agonist-independent regulation of constitutively active G-protein-coupled receptors. Trends in Biochemical Sciences. 23: 418-22. PMID 9852759 DOI: 10.1016/S0968-0004(98)01287-0 |
0.812 |
|
| 1998 |
Smit MJ, Verzijl D, Iyengar R. Identity of adenylyl cyclase isoform determines the rate of cell cycle progression in NIH 3T3 cells. Proceedings of the National Academy of Sciences of the United States of America. 95: 15084-9. PMID 9844019 DOI: 10.1073/Pnas.95.25.15084 |
0.358 |
|
| 1998 |
Alewijnse AE, Smit MJ, Hoffmann M, Verzijl D, Timmerman H, Leurs R. Constitutive activity and structural instability of the wild-type human H2 receptor. Journal of Neurochemistry. 71: 799-807. PMID 9681472 DOI: 10.1046/J.1471-4159.1998.71020799.X |
0.838 |
|
| 1998 |
Smit MJ, Timmerman H, Alewijnse AE, Leurs R. From histamine H2 receptor regulation to reclassification of H2 antagonists; inverse agonism as the basis for H2 receptor upregulation. Receptors & Channels. 5: 99-102. PMID 9606714 |
0.803 |
|
| 1998 |
Chen J, Bander JA, Santore TA, Chen Y, Ram PT, Smit MJ, Iyengar R. Expression of Q227L-galphas in MCF-7 human breast cancer cells inhibits tumorigenesis. Proceedings of the National Academy of Sciences of the United States of America. 95: 2648-52. PMID 9482941 DOI: 10.1073/Pnas.95.5.2648 |
0.332 |
|
| 1998 |
Bloemers SM, Verheule S, Peppelenbosch MP, Smit MJ, Tertoolen LG, de Laat S. Sensitization of the histamine H1 receptor by increased ligand affinity. The Journal of Biological Chemistry. 273: 2249-55. PMID 9442068 DOI: 10.1074/Jbc.273.4.2249 |
0.534 |
|
| 1998 |
Smit MJ, Iyengar R. Mammalian adenylyl cyclases. Advances in Second Messenger and Phosphoprotein Research. 32: 1-21. PMID 9421583 DOI: 10.1016/S1040-7952(98)80003-7 |
0.327 |
|
| 1997 |
Alewijnse AE, Smit MJ, Rodriguez Pena MS, Verzijl D, Timmerman H, Leurs R. Modulation of forskolin-mediated adenylyl cyclase activation by constitutively active G(S)-coupled receptors. Febs Letters. 419: 171-4. PMID 9428628 DOI: 10.1016/S0014-5793(97)01440-3 |
0.834 |
|
| 1997 |
Chen Y, Harry A, Li J, Smit MJ, Bai X, Magnusson R, Pieroni JP, Weng G, Iyengar R. Adenylyl cyclase 6 is selectively regulated by protein kinase A phosphorylation in a region involved in Galphas stimulation. Proceedings of the National Academy of Sciences of the United States of America. 94: 14100-4. PMID 9391159 DOI: 10.1073/Pnas.94.25.14100 |
0.325 |
|
| 1996 |
Smit MJ, Timmerman H, Hijzelendoorn JC, Fukui H, Leurs R. Regulation of the human histamine H1 receptor stably expressed in Chinese hamster ovary cells. British Journal of Pharmacology. 117: 1071-80. PMID 8882599 DOI: 10.1111/J.1476-5381.1996.Tb16699.X |
0.788 |
|
| 1996 |
Smit MJ, Timmerman H, Blauw J, Beukers MW, Roovers E, Jacobs EH, Hoffmann M, Leurs R. The C terminal tail of the histamine H2 receptor contains positive and negative signals important for signal transduction and receptor down-regulation. Journal of Neurochemistry. 67: 1791-800. PMID 8863482 DOI: 10.1046/J.1471-4159.1996.67051791.X |
0.815 |
|
| 1996 |
Smit MJ, Leurs R, Alewijnse AE, Blauw J, Van Nieuw Amerongen GP, Van De Vrede Y, Roovers E, Timmerman H. Inverse agonism of histamine H2 antagonist accounts for upregulation of spontaneously active histamine H2 receptors. Proceedings of the National Academy of Sciences of the United States of America. 93: 6802-7. PMID 8692899 DOI: 10.1073/Pnas.93.13.6802 |
0.822 |
|
| 1996 |
Smit MJ, Roovers E, Timmerman H, van de Vrede Y, Alewijnse AE, Leurs R. Two distinct pathways for histamine H2 receptor down-regulation. H2 Leu124 --> Ala receptor mutant provides evidence for a cAMP-independent action of H2 agonists. The Journal of Biological Chemistry. 271: 7574-82. PMID 8631790 DOI: 10.1074/Jbc.271.13.7574 |
0.832 |
|
| 1995 |
ter Laak AM, Timmerman H, Leurs R, Nederkoorn PH, Smit MJ, Donné-Op den Kelder GM. Modelling and mutation studies on the histamine H1-receptor agonist binding site reveal different binding modes for H1-agonists: Asp116 (TM3) has a constitutive role in receptor stimulation. Journal of Computer-Aided Molecular Design. 9: 319-30. PMID 8523041 DOI: 10.1007/Bf00125173 |
0.822 |
|
| 1995 |
Leurs R, Smit MJ, Meeder R, Ter Laak AM, Timmerman H. Lysine200 located in the fifth transmembrane domain of the histamine H1 receptor interacts with histamine but not with all H1 agonists. Biochemical and Biophysical Research Communications. 214: 110-7. PMID 7669031 DOI: 10.1006/Bbrc.1995.2263 |
0.826 |
|
| 1995 |
Smit MJ, Timmerman H, Alewijnse AE, Punin M, van den Nieuwenhof I, Blauw J, van Minnen J, Leurs R. Visualization of agonist-induced internalization of histamine H2 receptors. Biochemical and Biophysical Research Communications. 214: 1138-45. PMID 7575521 DOI: 10.1006/Bbrc.1995.2404 |
0.826 |
|
| 1995 |
Leurs R, Smit MJ, Timmerman H. Molecular pharmacological aspects of histamine receptors. Pharmacology & Therapeutics. 66: 413-63. PMID 7494855 DOI: 10.1016/0163-7258(95)00006-3 |
0.822 |
|
| 1994 |
Leurs R, Smit MJ, Tensen CP, Ter Laak AM, Timmerman H. Site-directed mutagenesis of the histamine H1-receptor reveals a selective interaction of asparagine207 with subclasses of H1-receptor agonists. Biochemical and Biophysical Research Communications. 201: 295-301. PMID 8198587 DOI: 10.1006/Bbrc.1994.1701 |
0.826 |
|
| 1994 |
Leurs R, Smit MJ, Menge WM, Timmerman H. Pharmacological characterization of the human histamine H2 receptor stably expressed in Chinese hamster ovary cells. British Journal of Pharmacology. 112: 847-54. PMID 7921611 DOI: 10.1111/J.1476-5381.1994.Tb13157.X |
0.828 |
|
| 1994 |
Smit MJ, Leurs R, Shukrula SR, Bast A, Timmerman H. Rapid desensitization of the histamine H2 receptor on the human monocytic cell line U937. European Journal of Pharmacology. 288: 17-25. PMID 7705464 DOI: 10.1016/0922-4106(94)90005-1 |
0.829 |
|
| 1993 |
Bloemers SM, Leurs R, Smit MJ, Verheule S, Tertoolen LG, Timmerman H, de Laat SW. Mouse P19 embryonal carcinoma cells express functional histamine H1-receptors. Biochemical and Biophysical Research Communications. 191: 118-25. PMID 8447817 DOI: 10.1006/Bbrc.1993.1192 |
0.792 |
|
| 1993 |
Smit MJ, Leurs R, Bloemers SM, Tertoolen LG, Bast A, De Laat SW, Timmerman H. Extracellular ATP elevates cytoplasmatic free Ca2+ in HeLa cells by the interaction with a 5'-nucleotide receptor. European Journal of Pharmacology. 247: 223-6. PMID 8282011 DOI: 10.1016/0922-4106(93)90082-K |
0.735 |
|
| 1992 |
Smit MJ, Bloemers SM, Leurs R, Tertoolen LG, Bast A, de Laat SW, Timmerman H. Short-term desensitization of the histamine H1 receptor in human HeLa cells: involvement of protein kinase C dependent and independent pathways. British Journal of Pharmacology. 107: 448-55. PMID 1422591 DOI: 10.1111/J.1476-5381.1992.Tb12766.X |
0.755 |
|
| 1991 |
Leurs R, Smit MJ, Bast A, Timmerman H. Different profiles of desensitization dynamics in guinea-pig jejunal longitudinal smooth muscle after stimulation with histamine and methacholine. British Journal of Pharmacology. 101: 881-8. PMID 2085711 DOI: 10.1111/J.1476-5381.1990.Tb14175.X |
0.756 |
|
| 1991 |
Leurs R, Smit MJ, Bast A, Timmerman H. Homologous histamine H1 receptor desensitization results in reduction of H1 receptor agonist efficacy. European Journal of Pharmacology. 196: 319-22. PMID 1654256 DOI: 10.1016/0014-2999(91)90446-W |
0.818 |
|
| 1991 |
Leurs R, Smit MJ, Brozius MM, Jansen W, Bast A, Timmerman H. Is protein kinase C involved in histamine H1-receptor desensitization? Agents and Actions. Supplements. 33: 393-402. PMID 1647131 |
0.788 |
|
| 1991 |
Leurs R, Brozius MM, Smit MJ, Bast A, Timmerman H. Effects of histamine H1-, H2- and H3-receptor selective drugs on the mechanical activity of guinea-pig small and large intestine. British Journal of Pharmacology. 102: 179-85. PMID 1646056 DOI: 10.1111/J.1476-5381.1991.Tb12150.X |
0.802 |
|
| 1990 |
Smit M, Leurs R, Bast A, Timmerman H. Homologous and heterologous desensitisation of histamine H1-receptor mediated contractions of guinea-pig jejunum European Journal of Pharmacology. 183: 2428-2429. DOI: 10.1016/0014-2999(90)94002-F |
0.823 |
|
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