Christian G. Specht, Ph.D. - Publications

2021- Inserm U1195, Université Paris-Saclay Diseases and Hormones of the Nervous System (DHNS) 
synuclein, inhibitory synapses, GABA receptors, single molecule localisation microscopy (SMLM), quantitative neurobiology

49 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2023 Wiessler AL, Hasenmüller AS, Fuhl I, Mille C, Campo OC, Reinhard N, Schenk J, Heinze KG, Schaefer N, Specht CG, Villmann C. Role of the glycine receptor ß subunit in synaptic localization and pathogenicity in severe startle disease. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. PMID 37963764 DOI: 10.1523/JNEUROSCI.0837-23.2023  0.357
2022 Khayenko V, Schulte C, Reis SL, Avraham O, Schietroma C, Worschech R, Nordblom NF, Kachler S, Villmann C, Heinze KG, Schlosser A, Schueler-Furman O, Tovote P, Specht CG, Maric HM. A Versatile Synthetic Affinity Probe Reveals Inhibitory Synapse Ultrastructure and Brain Connectivity. Angewandte Chemie (International Ed. in English). PMID 35421279 DOI: 10.1002/anie.202202078  0.35
2021 Maynard SA, Rostaing P, Schaefer N, Gemin O, Candat A, Dumoulin A, Villmann C, Triller A, Specht CG. Identification of a stereotypic molecular arrangement of endogenous glycine receptors at spinal cord synapses. Elife. 10. PMID 34878402 DOI: 10.7554/eLife.74441  0.575
2021 Specht CG. A Quantitative Perspective of Alpha-Synuclein Dynamics - Why Numbers Matter. Frontiers in Synaptic Neuroscience. 13: 753462. PMID 34744680 DOI: 10.3389/fnsyn.2021.753462  0.389
2021 Yang X, Le Corronc H, Legendre P, Triller A, Specht CG. Differential regulation of glycinergic and GABAergic nanocolumns at mixed inhibitory synapses. Embo Reports. e52154. PMID 34047007 DOI: 10.15252/embr.202052154  0.621
2021 Wagner S, Lee C, Rojas L, Specht CG, Rhee J, Brose N, Papadopoulos T. The α3 subunit of GABA receptors promotes formation of inhibitory synapses in the absence of collybistin. The Journal of Biological Chemistry. 100709. PMID 33901490 DOI: 10.1016/j.jbc.2021.100709  0.334
2021 Chapdelaine T, Hakim V, Triller A, Ranft J, Specht CG. Reciprocal stabilisation of glycine receptors and gephyrin scaffold proteins at inhibitory synapses. Biophysical Journal. PMID 33539789 DOI: 10.1016/j.bpj.2021.01.024  0.671
2020 Kostrz DN, Wayment-Steele HK, Wang J, Follenfant M, Pande VS, Triller A, Specht CG, Strick TR, Gosse C. A Modular DNA Scaffold to Study Protein-Protein Interactions at Single-Molecule Resolution Biophysical Journal. 118: 187a. DOI: 10.1016/J.Bpj.2019.11.1138  0.519
2019 Niwa F, Patrizio A, Triller A, Specht CG. cAMP-EPAC-Dependent Regulation of Gephyrin Phosphorylation and GABAR Trapping at Inhibitory Synapses. Iscience. 22: 453-465. PMID 31835170 DOI: 10.1016/j.isci.2019.11.013  0.668
2019 Yang X, Specht CG. Subsynaptic Domains in Super-Resolution Microscopy: The Treachery of Images. Frontiers in Molecular Neuroscience. 12: 161. PMID 31312120 DOI: 10.3389/fnmol.2019.00161  0.527
2019 Specht CG. Fractional occupancy of synaptic binding sites and the molecular plasticity of inhibitory synapses. Neuropharmacology. PMID 30648560 DOI: 10.1016/j.neuropharm.2019.01.008  0.522
2018 Grünewald N, Jan A, Salvatico C, Kress V, Renner M, Triller A, Specht CG, Schwarz G. Sequences Flanking the Gephyrin-Binding Site of GlyRβ Tune Receptor Stabilization at Synapses. Eneuro. 5. PMID 29464196 DOI: 10.1523/ENEURO.0042-17.2018  0.596
2017 Patrizio A, Renner M, Pizzarelli R, Triller A, Specht CG. Alpha subunit-dependent glycine receptor clustering and regulation of synaptic receptor numbers. Scientific Reports. 7: 10899. PMID 28883437 DOI: 10.1038/s41598-017-11264-3  0.634
2016 Patrizio A, Specht CG. Counting numbers of synaptic proteins: absolute quantification and single molecule imaging techniques. Neurophotonics. 3: 041805. PMID 27335891 DOI: 10.1117/1.NPh.3.4.041805  0.492
2016 Wang L, Dumoulin A, Renner M, Triller A, Specht CG. The Role of Synaptopodin in Membrane Protein Diffusion in the Dendritic Spine Neck. Plos One. 11: e0148310. PMID 26840625 DOI: 10.1371/journal.pone.0148310  0.635
2015 Plamont MA, Billon-Denis E, Maurin S, Gauron C, Pimenta FM, Specht CG, Shi J, Quérard J, Pan B, Rossignol J, Morellet N, Volovitch M, Lescop E, Chen Y, Triller A, et al. Small fluorescence-activating and absorption-shifting tag for tunable protein imaging in vivo. Proceedings of the National Academy of Sciences of the United States of America. PMID 26711992 DOI: 10.1073/Pnas.1513094113  0.522
2015 Salvatico C, Specht CG, Triller A. Synaptic receptor dynamics: from theoretical concepts to deep quantification and chemistry in cellulo. Neuropharmacology. 88: 2-9. PMID 25261785 DOI: 10.1016/j.neuropharm.2014.09.020  0.657
2015 El Beheiry M, Masson J, Salvatico C, Specht C, Triller A, Dahan M. Dynamics of Glycine Receptors and their Interactions with Gephyrin Scaffolds Revealed with High-Density Single Particle Tracking and Bayesian Inference Biophysical Journal. 108: 207a. DOI: 10.1016/j.bpj.2014.11.1143  0.662
2014 Gouzer G, Specht CG, Allain L, Shinoe T, Triller A. Benzodiazepine-dependent stabilization of GABA(A) receptors at synapses. Molecular and Cellular Neurosciences. 63: 101-13. PMID 25466558 DOI: 10.1016/j.mcn.2014.10.004  0.718
2014 Petkovic M, Jemaiel A, Daste F, Specht CG, Izeddin I, Vorkel D, Verbavatz JM, Darzacq X, Triller A, Pfenninger KH, Tareste D, Jackson CL, Galli T. The SNARE Sec22b has a non-fusogenic function in plasma membrane expansion. Nature Cell Biology. 16: 434-44. PMID 24705552 DOI: 10.1038/Ncb2937  0.516
2014 Masson JB, Dionne P, Salvatico C, Renner M, Specht CG, Triller A, Dahan M. Mapping the energy and diffusion landscapes of membrane proteins at the cell surface using high-density single-molecule imaging and Bayesian inference: application to the multiscale dynamics of glycine receptors in the neuronal membrane. Biophysical Journal. 106: 74-83. PMID 24411239 DOI: 10.1016/j.bpj.2013.10.027  0.63
2014 masson j, el beheiry M, Salvatico C, Renner M, Specht CG, Triller A, Dahan M. Bridging the Gap Between PALM and Qdots Single Particle Tracking using Bayesian Inference and the Gillespie Scheme Biophysical Journal. 106: 808a-809a. DOI: 10.1016/j.bpj.2013.11.4432  0.526
2013 Specht CG, Izeddin I, Rodriguez PC, El Beheiry M, Rostaing P, Darzacq X, Dahan M, Triller A. Quantitative nanoscopy of inhibitory synapses: counting gephyrin molecules and receptor binding sites. Neuron. 79: 308-21. PMID 23889935 DOI: 10.1016/j.neuron.2013.05.013  0.664
2013 Masson J, Dionne P, Salvatico C, Renner M, Specht C, Triller A, Dahan M. Mapping the Energy Landscapes of the Glycine Receptor in the Post-Synaptic Neuronal Membrane Biophysical Journal. 104: 498a. DOI: 10.1016/j.bpj.2012.11.2749  0.635
2012 Izeddin I, Boulanger J, Racine V, Specht CG, Kechkar A, Nair D, Triller A, Choquet D, Dahan M, Sibarita JB. Wavelet analysis for single molecule localization microscopy. Optics Express. 20: 2081-95. PMID 22330449 DOI: 10.1364/Oe.20.002081  0.502
2012 Masson J, Dionne P, Renner M, Specht C, Triller A, Dahan M. The Diffusion and Energy Landscapes of Post-Synaptic Transmembrane Proteins Biophysical Journal. 102: 653a. DOI: 10.1016/j.bpj.2011.11.3556  0.669
2011 Sillibourne JE, Specht CG, Izeddin I, Hurbain I, Tran P, Triller A, Darzacq X, Dahan M, Bornens M. Assessing the localization of centrosomal proteins by PALM/STORM nanoscopy. Cytoskeleton (Hoboken, N.J.). 68: 619-27. PMID 21976302 DOI: 10.1002/Cm.20536  0.536
2011 Specht CG, Grünewald N, Pascual O, Rostgaard N, Schwarz G, Triller A. Regulation of glycine receptor diffusion properties and gephyrin interactions by protein kinase C. The Embo Journal. 30: 3842-53. PMID 21829170 DOI: 10.1038/Emboj.2011.276  0.696
2011 Li D, Specht CG, Waites CL, Butler-Munro C, Leal-Ortiz S, Foote JW, Genoux D, Garner CC, Montgomery JM. SAP97 directs NMDA receptor spine targeting and synaptic plasticity. The Journal of Physiology. 589: 4491-510. PMID 21768261 DOI: 10.1113/Jphysiol.2011.215566  0.751
2011 Izeddin I, Specht CG, Lelek M, Darzacq X, Triller A, Zimmer C, Dahan M. Super-resolution dynamic imaging of dendritic spines using a low-affinity photoconvertible actin probe. Plos One. 6: e15611. PMID 21264214 DOI: 10.1371/journal.pone.0015611  0.595
2010 Izeddin I, Specht CG, Lelek M, Zimmer C, Triller A, Darzacq X, Dahan M. Long-Term Super-Resolution Imaging of Actin Cytoeskeleton in Dendritic Spines Using a Low-Affinity Photoactivatable Probe Biophysical Journal. 98: 396a. DOI: 10.1016/j.bpj.2009.12.2134  0.643
2009 Chen PE, Errington ML, Kneussel M, Chen G, Annala AJ, Rudhard YH, Rast GF, Specht CG, Tigaret CM, Nassar MA, Morris RG, Bliss TV, Schoepfer R. Behavioral deficits and subregion-specific suppression of LTP in mice expressing a population of mutant NMDA receptors throughout the hippocampus. Learning & Memory (Cold Spring Harbor, N.Y.). 16: 635-44. PMID 19794189 DOI: 10.1101/Lm.1316909  0.697
2009 Jeyifous O, Waites CL, Specht CG, Fujisawa S, Schubert M, Lin EI, Marshall J, Aoki C, de Silva T, Montgomery JM, Garner CC, Green WN. SAP97 and CASK mediate sorting of NMDA receptors through a previously unknown secretory pathway. Nature Neuroscience. 12: 1011-9. PMID 19620977 DOI: 10.1038/Nn.2362  0.786
2009 Calamai M, Specht CG, Heller J, Alcor D, Machado P, Vannier C, Triller A. Gephyrin oligomerization controls GlyR mobility and synaptic clustering. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 29: 7639-48. PMID 19535575 DOI: 10.1523/Jneurosci.5711-08.2009  0.625
2009 Waites CL, Specht CG, Härtel K, Leal-Ortiz S, Genoux D, Li D, Drisdel RC, Jeyifous O, Cheyne JE, Green WN, Montgomery JM, Garner CC. Synaptic SAP97 isoforms regulate AMPA receptor dynamics and access to presynaptic glutamate. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 29: 4332-45. PMID 19357261 DOI: 10.1523/Jneurosci.4431-08.2009  0.795
2009 Izeddin I, Specht CG, Darzacq X, Triller A, Zimmer C, Dahan M. Imaging Actin Filaments in Synaptic Spines Beyond the Diffraction Limit of Light Biophysical Journal. 96: 637a. DOI: 10.1016/j.bpj.2008.12.3367  0.585
2008 Specht CG, Triller A. The dynamics of synaptic scaffolds. Bioessays : News and Reviews in Molecular, Cellular and Developmental Biology. 30: 1062-74. PMID 18937346 DOI: 10.1002/bies.20831  0.682
2008 Renner M, Specht CG, Triller A. Molecular dynamics of postsynaptic receptors and scaffold proteins. Current Opinion in Neurobiology. 18: 532-40. PMID 18832033 DOI: 10.1016/j.conb.2008.09.009  0.695
2008 Trinidad JC, Thalhammer A, Specht CG, Lynn AJ, Baker PR, Schoepfer R, Burlingame AL. Quantitative analysis of synaptic phosphorylation and protein expression. Molecular & Cellular Proteomics : McP. 7: 684-96. PMID 18056256 DOI: 10.1074/Mcp.M700170-Mcp200  0.712
2006 Vosseller K, Trinidad JC, Chalkley RJ, Specht CG, Thalhammer A, Lynn AJ, Snedecor JO, Guan S, Medzihradszky KF, Maltby DA, Schoepfer R, Burlingame AL. O-linked N-acetylglucosamine proteomics of postsynaptic density preparations using lectin weak affinity chromatography and mass spectrometry. Molecular & Cellular Proteomics : McP. 5: 923-34. PMID 16452088 DOI: 10.1074/Mcp.T500040-Mcp200  0.624
2006 Trinidad JC, Specht CG, Thalhammer A, Schoepfer R, Burlingame AL. Comprehensive identification of phosphorylation sites in postsynaptic density preparations. Molecular & Cellular Proteomics : McP. 5: 914-22. PMID 16452087 DOI: 10.1074/Mcp.T500041-Mcp200  0.643
2006 Tigaret CM, Thalhammer A, Rast GF, Specht CG, Auberson YP, Stewart MG, Schoepfer R. Subunit dependencies of N-methyl-D-aspartate (NMDA) receptor-induced alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor internalization. Molecular Pharmacology. 69: 1251-9. PMID 16436589 DOI: 10.1124/Mol.105.018580  0.673
2005 Trinidad JC, Thalhammer A, Specht CG, Schoepfer R, Burlingame AL. Phosphorylation state of postsynaptic density proteins. Journal of Neurochemistry. 92: 1306-16. PMID 15748150 DOI: 10.1111/J.1471-4159.2004.02943.X  0.691
2005 Specht CG, Tigaret CM, Rast GF, Thalhammer A, Rudhard Y, Schoepfer R. Subcellular localisation of recombinant alpha- and gamma-synuclein. Molecular and Cellular Neurosciences. 28: 326-34. PMID 15691713 DOI: 10.1016/J.Mcn.2004.09.017  0.615
2005 Specht CG, Williams OA, Jackman RB, Schoepfer R. Erratum to ‘Ordered growth of neurons on diamond’ Biomaterials. 26: 828. DOI: 10.1016/J.BIOMATERIALS.2004.06.022  0.584
2004 Specht CG, Schoepfer R. Deletion of multimerin-1 in alpha-synuclein-deficient mice. Genomics. 83: 1176-8. PMID 15177571 DOI: 10.1016/j.ygeno.2003.12.014  0.562
2004 Specht CG, Williams OA, Jackman RB, Schoepfer R. Ordered growth of neurons on diamond. Biomaterials. 25: 4073-8. PMID 15046898 DOI: 10.1016/j.biomaterials.2003.11.006  0.603
2002 Chen PE, Specht CG, Morris RG, Schoepfer R. Spatial learning is unimpaired in mice containing a deletion of the alpha-synuclein locus. The European Journal of Neuroscience. 16: 154-8. PMID 12153541 DOI: 10.1046/j.1460-9568.2002.02062.x  0.603
2001 Specht CG, Schoepfer R. Deletion of the alpha-synuclein locus in a subpopulation of C57BL/6J inbred mice. Bmc Neuroscience. 2: 11. PMID 11591219 DOI: 10.1186/1471-2202-2-11  0.604
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