Olivier George, Ph.D. - Publications

2006-2019 Neuroscience Scripps Research Institute, La Jolla, La Jolla, CA, United States 
 2019- Psychiatry University of California, San Diego, La Jolla, CA 
Addiction, Animal Models, Neuronal Ensembles, Prefrontal, Amygdala, Medication Development,

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Year Citation  Score
2022 Duttke SH, Montilla-Perez P, Chang MW, Li H, Chen H, Carrette LLG, de Guglielmo G, George O, Palmer AA, Benner C, Telese F. Glucocorticoid Receptor-Regulated Enhancers Play a Central Role in the Gene Regulatory Networks Underlying Drug Addiction. Frontiers in Neuroscience. 16: 858427. PMID 35651629 DOI: 10.3389/fnins.2022.858427  0.778
2022 Carrette LLG, Corral C, Boomhower B, Brennan M, Crook C, Ortez C, Shankar K, Simpson S, Maturin L, Solberg Woods LC, Palmer AA, de Guglielmo G, George O. Leptin Protects Against the Development and Expression of Cocaine Addiction-Like Behavior in Heterogeneous Stock Rats. Frontiers in Behavioral Neuroscience. 16: 832899. PMID 35316955 DOI: 10.3389/fnbeh.2022.832899  0.787
2022 Shankar K, Ambroggi F, George O. Microstructural meal pattern analysis reveals a paradoxical acute increase in food intake after nicotine despite its long-term anorexigenic effects. Psychopharmacology. PMID 35129671 DOI: 10.1007/s00213-022-06071-2  0.797
2021 Grieder TE, Yee M, Vargas-Perez H, Maal-Bared G, George S, Ting-A-Kee R, George O, van der Kooy D. Administration of BDNF in the ventral tegmental area produces a switch from a nicotine-non-dependent D1R-mediated motivational state to a nicotine-dependent-like D2R-mediated motivational state. The European Journal of Neuroscience. PMID 34963197 DOI: 10.1111/ejn.15579  0.805
2021 Kallupi M, Kononoff J, Melas PA, Qvist JS, de Guglielmo G, Kandel ER, George O. Deep brain stimulation of the nucleus accumbens shell attenuates cocaine withdrawal but increases cocaine self-administration, cocaine-induced locomotor activity, and GluR1/GluA1 in the central nucleus of the amygdala in male cocaine-dependent rats. Brain Stimulation. 15: 13-22. PMID 34742997 DOI: 10.1016/j.brs.2021.11.003  0.811
2021 Simpson S, Mclellan R, Wellmeyer E, Matalon F, George O. Drugs and Bugs: The Gut-Brain Axis and Substance Use Disorders. Journal of Neuroimmune Pharmacology : the Official Journal of the Society On Neuroimmune Pharmacology. PMID 34694571 DOI: 10.1007/s11481-021-10022-7  0.6
2021 Avelar AJ, George O. How nicotine withdrawal symptoms fight each other: interpeduncular GABA neuron activity dynamically controls negative affect vs. coping behavior. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. PMID 34593977 DOI: 10.1038/s41386-021-01185-1  0.791
2021 Kimbrough A, Kallupi M, Smith LC, Simpson S, Collazo A, George O. Characterization of the brain functional architecture of psychostimulant withdrawal using single-cell whole brain imaging. Eneuro. PMID 34580158 DOI: 10.1523/ENEURO.0208-19.2021  0.8
2021 Sedighim S, Carrette LL, Venniro M, Shaham Y, de Guglielmo G, George O. Individual differences in addiction-like behaviors and choice between cocaine versus food in Heterogeneous Stock rats. Psychopharmacology. PMID 34415376 DOI: 10.1007/s00213-021-05961-1  0.815
2021 Simpson S, Chen Y, Wellmeyer E, Smith LC, Aragon Montes B, George O, Kimbrough A. The Hidden Brain: Uncovering Previously Overlooked Brain Regions by Employing Novel Preclinical Unbiased Network Approaches. Frontiers in Systems Neuroscience. 15: 595507. PMID 33967705 DOI: 10.3389/fnsys.2021.595507  0.775
2021 Smith LC, Tieu L, Suhandynata RT, Boomhower B, Hoffman M, Sepulveda Y, Carrette LLG, Momper JD, Fitzgerald RL, Hanham K, Dowling J, Kallupi M, George O. Cannabidiol reduces withdrawal symptoms in nicotine-dependent rats. Psychopharmacology. PMID 33909102 DOI: 10.1007/s00213-021-05845-4  0.813
2021 Carrette LL, de Guglielmo G, Kallupi M, Maturin L, Brennan M, Boomhower B, Conlisk D, Sedighim S, Tieu L, Fannon MJ, Velarde N, Kononoff J, Kimbrough A, Simpson S, Smith LC, ... ... George O, et al. The cocaine and oxycodone biobanks, two repositories from genetically diverse and behaviorally characterized rats for the study of addiction. Eneuro. PMID 33875455 DOI: 10.1523/ENEURO.0033-21.2021  0.749
2021 McGinn MA, Tunstall BJ, Schlosburg JE, Gregory-Flores A, George O, de Guglielmo G, Mason BJ, Hunt HJ, Koob GF, Vendruscolo LF. Glucocorticoid receptor modulators decrease alcohol self-administration in male rats. Neuropharmacology. 108510. PMID 33647278 DOI: 10.1016/j.neuropharm.2021.108510  0.81
2020 Smith LC, George O. Advances in smoking cessation pharmacotherapy: Non-nicotinic approaches in animal models. Neuropharmacology. 108225. PMID 32758566 DOI: 10.1016/J.Neuropharm.2020.108225  0.572
2020 Smith LC, Kallupi M, Tieu L, Shankar K, Jaquish A, Barr J, Su Y, Velarde N, Sedighim S, Carrette LLG, Klodnicki M, Sun X, de Guglielmo G, George O. Validation of a nicotine vapor self-administration model in rats with relevance to electronic cigarette use. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. PMID 32544927 DOI: 10.1038/S41386-020-0734-8  0.805
2020 Simpson S, Kimbrough A, Boomhower B, McLellan R, Hughes M, Shankar K, de Guglielmo G, George O. Depletion of the Microbiome Alters the Recruitment of Neuronal Ensembles of Oxycodone Intoxication and Withdrawal. Eneuro. PMID 32341122 DOI: 10.1523/ENEURO.0312-19.2020  0.789
2020 Simpson S, Shankar K, Kimbrough A, George O. Role of Corticotropin-Releasing Factor in Alcohol and Nicotine Addiction. Brain Research. 146850. PMID 32330519 DOI: 10.1016/J.Brainres.2020.146850  0.82
2020 Kimbrough A, Kononoff J, Simpson S, Kallupi M, Sedighim S, Palomino K, Conlisk D, Momper JD, de Guglielmo G, George O. Oxycodone self-administration and withdrawal behaviors in male and female Wistar rats. Psychopharmacology. PMID 32114633 DOI: 10.1007/S00213-020-05479-Y  0.781
2020 Lee CH, George O, Kimbrough A. Chronic voluntary caffeine intake in male Wistar rats reveals individual differences in addiction-like behavior. Pharmacology, Biochemistry, and Behavior. 172880. PMID 32105663 DOI: 10.1016/J.Pbb.2020.172880  0.771
2020 Kimbrough A, Lurie DJ, Collazo A, Kreifeldt M, Sidhu H, Macedo GC, D'Esposito M, Contet C, George O. Brain-wide functional architecture remodeling by alcohol dependence and abstinence. Proceedings of the National Academy of Sciences of the United States of America. PMID 31937658 DOI: 10.1073/Pnas.1909915117  0.799
2020 Kallupi M, Carrette LLG, Kononoff J, Solberg Woods LC, Palmer AA, Schweitzer P, George O, de Guglielmo G. Nociceptin attenuates the escalation of oxycodone self-administration by normalizing CeA-GABA transmission in highly addicted rats. Proceedings of the National Academy of Sciences of the United States of America. PMID 31932450 DOI: 10.1073/Pnas.1915143117  0.806
2019 de Guglielmo G, Kallupi M, Sedighim S, Newman AH, George O. Dopamine D Receptor Antagonism Reverses the Escalation of Oxycodone Self-administration and Decreases Withdrawal-Induced Hyperalgesia and Irritability-Like Behavior in Oxycodone-Dependent Heterogeneous Stock Rats. Frontiers in Behavioral Neuroscience. 13: 292. PMID 31992976 DOI: 10.3389/Fnbeh.2019.00292  0.808
2019 de Guglielmo G, Fu Y, Chen J, Larrosa E, Hoang I, Kawamura T, Lorrai I, Zorman B, Bryant J, George O, Sumazin P, Lefebvre C, Repunte-Canonigo V, Paolo Sanna P. Increases in compulsivity, inflammation, and neural injury in HIV transgenic rats with escalated methamphetamine self-administration under extended-access conditions. Brain Research. 146502. PMID 31605699 DOI: 10.1016/J.Brainres.2019.146502  0.713
2019 Spierling S, de Guglielmo G, Kirson D, Kreisler A, Roberto M, George O, Zorrilla EP. Insula to ventral striatal projections mediate compulsive eating produced by intermittent access to palatable food. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. PMID 31593982 DOI: 10.1038/S41386-019-0538-X  0.809
2019 Kallupi M, de Guglielmo G, Larrosa E, George O. Exposure to passive nicotine vapor in male adolescent rats produces a withdrawal-like state and facilitates nicotine self-administration during adulthood. European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology. PMID 31462388 DOI: 10.1016/J.Euroneuro.2019.08.299  0.815
2019 Goulding SP, de Guglielmo G, Carrette LLG, George O, Contet C. Systemic administration of the cyclin-dependent kinase inhibitor (S)-CR8 selectively reduces escalated ethanol intake in dependent rats. Alcoholism, Clinical and Experimental Research. PMID 31403700 DOI: 10.1111/Acer.14177  0.793
2019 de Guglielmo G, Kallupi M, Pomrenze MB, Crawford E, Simpson S, Schweitzer P, Koob GF, Messing RO, George O. Inactivation of a CRF-dependent amygdalofugal pathway reverses addiction-like behaviors in alcohol-dependent rats. Nature Communications. 10: 1238. PMID 30886240 DOI: 10.1038/S41467-019-09183-0  0.812
2018 Kallupi M, Xue S, Zhou B, Janda KD, George O. An enzymatic approach reverses nicotine dependence, decreases compulsive-like intake, and prevents relapse. Science Advances. 4: eaat4751. PMID 30345354 DOI: 10.1126/Sciadv.Aat4751  0.723
2018 Kononoff J, Melas PA, Kallupi M, de Guglielmo G, Kimbrough A, Scherma M, Fadda P, Kandel DB, Kandel ER, George O. Adolescent cannabinoid exposure induces irritability-like behavior and cocaine cross-sensitization without affecting the escalation of cocaine self-administration in adulthood. Scientific Reports. 8: 13893. PMID 30224774 DOI: 10.1038/S41598-018-31921-5  0.812
2018 Keller JA, Chen J, Simpson S, Wang EH, Lilascharoen V, George O, Lim BK, Stowers L. Voluntary urination control by brainstem neurons that relax the urethral sphincter. Nature Neuroscience. PMID 30104734 DOI: 10.1038/S41593-018-0204-3  0.595
2018 Kononoff J, Kallupi M, Kimbrough A, Conlisk D, de Guglielmo G, George O. Systemic and Intra-Habenular Activation of the Orphan G Protein-Coupled Receptor GPR139 Decreases Compulsive-Like Alcohol Drinking and Hyperalgesia in Alcohol-Dependent Rats. Eneuro. 5. PMID 29971251 DOI: 10.1523/ENEURO.0153-18.2018  0.804
2018 Pelloux Y, Degoulet M, Tiran-Cappello A, Cohen C, Lardeux S, George O, Koob GF, Ahmed SH, Baunez C. Subthalamic nucleus high frequency stimulation prevents and reverses escalated cocaine use. Molecular Psychiatry. PMID 29880881 DOI: 10.1038/S41380-018-0080-Y  0.763
2018 de Guglielmo G, Conlisk DE, Barkley-Levenson AM, Palmer AA, George O. Inhibition of Glyoxalase 1 reduces alcohol self-administration in dependent and nondependent rats. Pharmacology, Biochemistry, and Behavior. PMID 29505808 DOI: 10.1016/J.Pbb.2018.03.001  0.81
2018 Rupprecht LE, Kreisler AD, Spierling SR, de Guglielmo G, Kallupi M, George O, Donny EC, Zorrilla EP, Sved AF. Self-administered nicotine increases fat metabolism and suppresses weight gain in male rats. Psychopharmacology. PMID 29354872 DOI: 10.1007/S00213-018-4830-Y  0.801
2018 Xue S, Kallupi M, Zhou B, Smith LC, Miranda PO, George O, Janda KD. An enzymatic advance in nicotine cessation therapy. Chemical Communications (Cambridge, England). PMID 29308799 DOI: 10.1039/C7Cc09134F  0.741
2017 Verheij MMM, Contet C, Karel P, Latour J, van der Doelen RHA, Geenen B, van Hulten JA, Meyer F, Kozicz T, George O, Koob GF, Homberg JR. Median and Dorsal Raphe Serotonergic Neurons Control Moderate Versus Compulsive Cocaine Intake. Biological Psychiatry. PMID 29357981 DOI: 10.1016/J.Biopsych.2017.10.031  0.781
2017 George O, Koob GF. Individual differences in the neuropsychopathology of addiction. Dialogues in Clinical Neuroscience. 19: 217-229. PMID 29302219  0.555
2017 Matzeu A, Kallupi M, George O, Schweitzer P, Martin-Fardon R. Dynorphin Counteracts Orexin in the Paraventricular Nucleus of the Thalamus: Cellular and Behavioral Evidence. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. PMID 29052613 DOI: 10.1038/Npp.2017.250  0.747
2017 Kimbrough A, de Guglielmo G, Kononoff J, Kallupi M, Zorrilla EP, George O. CRF1 receptor-dependent increases in irritability-like behavior during abstinence from chronic intermittent ethanol vapor exposure. Alcoholism, Clinical and Experimental Research. PMID 28833238 DOI: 10.1111/Acer.13484  0.787
2017 Vendruscolo JC, Tunstall BJ, Carmack SA, Schmeichel BE, Lowery-Gionta EG, Cole M, George O, Vandewater S, Taffe M, Koob GF, Vendruscolo LF. Compulsive-Like Sufentanil Vapor Self-Administration in the Rat. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. PMID 28812595 DOI: 10.1038/Npp.2017.172  0.794
2017 Kimbrough A, Kim S, Cole M, Brennan M, George O. Intermittent Access to Ethanol Drinking Facilitates the Transition to Excessive Drinking After Chronic Intermittent Ethanol Vapor Exposure. Alcoholism, Clinical and Experimental Research. PMID 28679148 DOI: 10.1111/Acer.13434  0.793
2017 Kallupi M, George O. Nicotine Vapor Method to Induce Nicotine Dependence in Rodents. Current Protocols in Neuroscience. 80: 8.41.1-8.41.10. PMID 28678400 DOI: 10.1002/Cpns.34  0.693
2017 de Guglielmo G, Matzeu A, Kononoff J, Mattioni J, Martin-Fardon R, George O. Cebranopadol blocks the escalation of cocaine intake and conditioned reinstatement of cocaine seeking in rats. The Journal of Pharmacology and Experimental Therapeutics. PMID 28645915 DOI: 10.1124/Jpet.117.241042  0.82
2017 Grieder TE, George O, Yee M, Bergamini MA, Chwalek M, Maal-Bared G, Vargas-Perez H, van der Kooy D. Deletion of α5 nicotine receptor subunits abolishes nicotinic aversive motivational effects in a manner that phenocopies dopamine receptor antagonism. The European Journal of Neuroscience. PMID 28498560 DOI: 10.1111/Ejn.13605  0.8
2017 George O, Hope BT. Cortical and amygdalar neuronal ensembles in alcohol seeking, drinking and withdrawal. Neuropharmacology. PMID 28435008 DOI: 10.1016/J.Neuropharm.2017.04.031  0.405
2017 Varodayan FP, de Guglielmo G, Logrip ML, George O, Roberto M. Alcohol dependence disrupts amygdalar L-type voltage-gated calcium channel mechanisms. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. PMID 28363981 DOI: 10.1523/Jneurosci.3721-16.2017  0.76
2017 de Guglielmo G, Kallupi M, Cole MD, George O. Voluntary induction and maintenance of alcohol dependence in rats using alcohol vapor self-administration. Psychopharmacology. PMID 28342089 DOI: 10.1007/S00213-017-4608-7  0.813
2017 de Guglielmo G, Kallupi M, Crawford E, Koob GF, Messing RO, George O. Optogenetic characterization of CeA CRF pathways in alcohol dependence Alcohol. 60: 235. DOI: 10.1016/J.Alcohol.2017.02.319  0.754
2017 George O. Chemogenetic and optogenetic control of excessive alcohol drinking through inactivation of a neuronal ensemble in the central nucleus of the amygdala Alcohol. 60: 214. DOI: 10.1016/J.Alcohol.2017.02.232  0.334
2017 Messing RO, Pomrenze MB, de Guglielmo G, Kallupi M, Koob GF, George O. A distributed CRF network in rat extended amygdala regulates anxiety and excessive alcohol drinking Alcohol. 60: 212. DOI: 10.1016/J.Alcohol.2017.02.221  0.759
2016 Harris RA, Bajo M, Bell RL, Blednov YA, Varodayan FP, Truitt J, de Guglielmo G, Lasek AW, Logrip ML, Vendruscolo LF, Roberts AJ, Roberts E, George O, Mayfield J, Billiar TR, et al. Genetic and pharmacologic manipulation of TLR4 has minimal impact on ethanol consumption in rodents. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. PMID 27986929 DOI: 10.1523/Jneurosci.2002-16.2016  0.794
2016 Wade CL, Kallupi M, Hernandez DO, Breysse E, de Guglielmo G, Crawford E, Koob GF, Schweitzer P, Baunez C, George O. High-Frequency Stimulation of the Subthalamic Nucleus Blocks Compulsive-Like Re-Escalation of Heroin Taking in Rats. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. PMID 27917870 DOI: 10.1038/Npp.2016.270  0.814
2016 de Guglielmo G, Crawford E, Kim S, Vendruscolo LF, Hope BT, Brennan M, Cole M, Koob GF, George O. Recruitment of a Neuronal Ensemble in the Central Nucleus of the Amygdala Is Required for Alcohol Dependence. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 36: 9446-53. PMID 27605618 DOI: 10.1523/Jneurosci.1395-16.2016  0.796
2015 Pomrenze MB, Millan EZ, Hopf FW, Keiflin R, Maiya R, Blasio A, Dadgar J, Kharazia V, De Guglielmo G, Crawford E, Janak PH, George O, Rice KC, Messing RO. A Transgenic Rat for Investigating the Anatomy and Function of Corticotrophin Releasing Factor Circuits. Frontiers in Neuroscience. 9: 487. PMID 26733798 DOI: 10.3389/Fnins.2015.00487  0.679
2015 Vendruscolo LF, Estey D, Goodell V, Macshane LG, Logrip ML, Schlosburg JE, McGinn MA, Zamora-Martinez ER, Belanoff JK, Hunt HJ, Sanna PP, George O, Koob GF, Edwards S, Mason BJ. Glucocorticoid receptor antagonism decreases alcohol seeking in alcohol-dependent individuals. The Journal of Clinical Investigation. PMID 26121746 DOI: 10.1172/Jci79828  0.802
2015 Zhao-Shea R, DeGroot SR, Liu L, Vallaster M, Pang X, Su Q, Gao G, Rando OJ, Martin GE, George O, Gardner PD, Tapper AR. Increased CRF signalling in a ventral tegmental area-interpeduncular nucleus-medial habenula circuit induces anxiety during nicotine withdrawal. Nature Communications. 6: 6770. PMID 25898242 DOI: 10.1038/Ncomms7770  0.379
2015 Leão RM, Cruz FC, Vendruscolo LF, de Guglielmo G, Logrip ML, Planeta CS, Hope BT, Koob GF, George O. Chronic nicotine activates stress/reward-related brain regions and facilitates the transition to compulsive alcohol drinking. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 35: 6241-53. PMID 25878294 DOI: 10.1523/Jneurosci.3302-14.2015  0.797
2015 Whitfield TW, Schlosburg JE, Wee S, Gould A, George O, Grant Y, Zamora-Martinez ER, Edwards S, Crawford E, Vendruscolo LF, Koob GF. κ Opioid receptors in the nucleus accumbens shell mediate escalation of methamphetamine intake. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 35: 4296-305. PMID 25762676 DOI: 10.1523/Jneurosci.1978-13.2015  0.82
2015 Cohen A, Soleiman MT, Talia R, Koob GF, George O, Mandyam CD. Extended access nicotine self-administration with periodic deprivation increases immature neurons in the hippocampus. Psychopharmacology. 232: 453-63. PMID 25059540 DOI: 10.1007/S00213-014-3685-0  0.695
2015 Cohen A, Treweek J, Edwards S, Leão RM, Schulteis G, Koob GF, George O. Extended access to nicotine leads to a CRF1 receptor dependent increase in anxiety-like behavior and hyperalgesia in rats. Addiction Biology. 20: 56-68. PMID 23869743 DOI: 10.1111/Adb.12077  0.779
2014 Grieder TE, Herman MA, Contet C, Tan LA, Vargas-Perez H, Cohen A, Chwalek M, Maal-Bared G, Freiling J, Schlosburg JE, Clarke L, Crawford E, Koebel P, Repunte-Canonigo V, Sanna PP, ... ... George O, et al. VTA CRF neurons mediate the aversive effects of nicotine withdrawal and promote intake escalation. Nature Neuroscience. 17: 1751-8. PMID 25402857 DOI: 10.1038/Nn.3872  0.8
2014 Repunte-Canonigo V, Lefebvre C, George O, Kawamura T, Morales M, Koob GF, Califano A, Masliah E, Sanna PP. Gene expression changes consistent with neuroAIDS and impaired working memory in HIV-1 transgenic rats. Molecular Neurodegeneration. 9: 26. PMID 24980976 DOI: 10.1186/1750-1326-9-26  0.52
2014 George O, Koob GF, Vendruscolo LF. Negative reinforcement via motivational withdrawal is the driving force behind the transition to addiction. Psychopharmacology. 231: 3911-7. PMID 24923982 DOI: 10.1007/S00213-014-3623-1  0.542
2014 Buck CL, Malavar JC, George O, Koob GF, Vendruscolo LF. Anticipatory 50 kHz ultrasonic vocalizations are associated with escalated alcohol intake in dependent rats. Behavioural Brain Research. 271: 171-6. PMID 24914463 DOI: 10.1016/J.Bbr.2014.06.003  0.627
2014 Cohen A, Whitfield TW, Kreifeldt M, Koebel P, Kieffer BL, Contet C, George O, Koob GF. Virus-mediated shRNA knockdown of prodynorphin in the rat nucleus accumbens attenuates depression-like behavior and cocaine locomotor sensitization. Plos One. 9: e97216. PMID 24816773 DOI: 10.1371/Journal.Pone.0097216  0.824
2014 Buck CL, Vendruscolo LF, Koob GF, George O. Dopamine D1 and μ-opioid receptor antagonism blocks anticipatory 50 kHz ultrasonic vocalizations induced by palatable food cues in Wistar rats. Psychopharmacology. 231: 929-37. PMID 24221826 DOI: 10.1007/S00213-013-3307-2  0.602
2014 Koob GF, Buck CL, Cohen A, Edwards S, Park PE, Schlosburg JE, Schmeichel B, Vendruscolo LF, Wade CL, Whitfield TW, George O. Addiction as a stress surfeit disorder. Neuropharmacology. 76: 370-82. PMID 23747571 DOI: 10.1016/J.Neuropharm.2013.05.024  0.806
2014 Kallupi M, Vendruscolo LF, Carmichael CY, George O, Koob GF, Gilpin NW. Neuropeptide YY(2)R blockade in the central amygdala reduces anxiety-like behavior but not alcohol drinking in alcohol-dependent rats. Addiction Biology. 19: 755-7. PMID 23639035 DOI: 10.1111/Adb.12059  0.807
2014 Deschaux O, Vendruscolo LF, Schlosburg JE, Diaz-Aguilar L, Yuan CJ, Sobieraj JC, George O, Koob GF, Mandyam CD. Hippocampal neurogenesis protects against cocaine-primed relapse. Addiction Biology. 19: 562-74. PMID 23278919 DOI: 10.1111/Adb.12019  0.795
2014 Gilpin NW, Whitaker AM, Baynes B, Abdel AY, Weil MT, George O. Nicotine vapor inhalation escalates nicotine self-administration. Addiction Biology. 19: 587-92. PMID 23240929 DOI: 10.1111/Adb.12021  0.677
2013 Schlosburg JE, Whitfield TW, Park PE, Crawford EF, George O, Vendruscolo LF, Koob GF. Long-term antagonism of κ opioid receptors prevents escalation of and increased motivation for heroin intake. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 33: 19384-92. PMID 24305833 DOI: 10.1523/Jneurosci.1979-13.2013  0.787
2013 Cohen A, George O. Animal models of nicotine exposure: relevance to second-hand smoking, electronic cigarette use, and compulsive smoking. Frontiers in Psychiatry. 4: 41. PMID 23761766 DOI: 10.3389/Fpsyt.2013.00041  0.567
2013 George O, Koob GF. Control of craving by the prefrontal cortex. Proceedings of the National Academy of Sciences of the United States of America. 110: 4165-6. PMID 23483010 DOI: 10.1073/Pnas.1301245110  0.562
2012 George O, Sanders C, Freiling J, Grigoryan E, Vu S, Allen CD, Crawford E, Mandyam CD, Koob GF. Recruitment of medial prefrontal cortex neurons during alcohol withdrawal predicts cognitive impairment and excessive alcohol drinking. Proceedings of the National Academy of Sciences of the United States of America. 109: 18156-61. PMID 23071333 DOI: 10.1073/Pnas.1116523109  0.614
2012 Cohen A, Koob GF, George O. Robust escalation of nicotine intake with extended access to nicotine self-administration and intermittent periods of abstinence. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 37: 2153-60. PMID 22549121 DOI: 10.1038/Npp.2012.67  0.695
2012 Tobey KM, Walentiny DM, Wiley JL, Carroll FI, Damaj MI, Azar MR, Koob GF, George O, Harris LS, Vann RE. Effects of the specific α4β2 nAChR antagonist, 2-fluoro-3-(4-nitrophenyl) deschloroepibatidine, on nicotine reward-related behaviors in rats and mice. Psychopharmacology. 223: 159-68. PMID 22526534 DOI: 10.1007/S00213-012-2703-3  0.624
2012 Goeders NE, Cohen A, Fox BS, Azar MR, George O, Koob GF. Effects of the combination of metyrapone and oxazepam on intravenous nicotine self-administration in rats. Psychopharmacology. 223: 17-25. PMID 22418732 DOI: 10.1007/S00213-012-2682-4  0.69
2012 Grieder TE, George O, Tan H, George SR, Le Foll B, Laviolette SR, van der Kooy D. Phasic D1 and tonic D2 dopamine receptor signaling double dissociate the motivational effects of acute nicotine and chronic nicotine withdrawal. Proceedings of the National Academy of Sciences of the United States of America. 109: 3101-6. PMID 22308372 DOI: 10.1073/Pnas.1114422109  0.807
2012 Recinto P, Samant AR, Chavez G, Kim A, Yuan CJ, Soleiman M, Grant Y, Edwards S, Wee S, Koob GF, George O, Mandyam CD. Levels of neural progenitors in the hippocampus predict memory impairment and relapse to drug seeking as a function of excessive methamphetamine self-administration. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 37: 1275-87. PMID 22205547 DOI: 10.1038/Npp.2011.315  0.71
2012 George O, Le Moal M, Koob GF. Allostasis and addiction: role of the dopamine and corticotropin-releasing factor systems. Physiology & Behavior. 106: 58-64. PMID 22108506 DOI: 10.1016/J.Physbeh.2011.11.004  0.719
2011 George O, Koob GF. Craving, context and the cortex. Nature Neuroscience. 14: 409-10. PMID 21445066 DOI: 10.1038/Nn.2787  0.548
2011 George O, Lloyd A, Carroll FI, Damaj MI, Koob GF. Varenicline blocks nicotine intake in rats with extended access to nicotine self-administration. Psychopharmacology. 213: 715-22. PMID 20924754 DOI: 10.1007/S00213-010-2024-3  0.614
2010 George O, Koob GF. Individual differences in prefrontal cortex function and the transition from drug use to drug dependence. Neuroscience and Biobehavioral Reviews. 35: 232-47. PMID 20493211 DOI: 10.1016/J.Neubiorev.2010.05.002  0.575
2010 George O, Vallée M, Vitiello S, Le Moal M, Piazza PV, Mayo W. Low brain allopregnanolone levels mediate flattened circadian activity associated with memory impairments in aged rats. Biological Psychiatry. 68: 956-63. PMID 20471631 DOI: 10.1016/J.Biopsych.2010.03.022  0.779
2010 George O, Grieder TE, Cole M, Koob GF. Exposure to chronic intermittent nicotine vapor induces nicotine dependence. Pharmacology, Biochemistry, and Behavior. 96: 104-7. PMID 20420848 DOI: 10.1016/J.Pbb.2010.04.013  0.797
2009 Orio L, Edwards S, George O, Parsons LH, Koob GF. A role for the endocannabinoid system in the increased motivation for cocaine in extended-access conditions. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 29: 4846-57. PMID 19369553 DOI: 10.1523/Jneurosci.0563-09.2009  0.829
2008 George O, Mandyam CD, Wee S, Koob GF. Extended access to cocaine self-administration produces long-lasting prefrontal cortex-dependent working memory impairments. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 33: 2474-82. PMID 18033234 DOI: 10.1038/Sj.Npp.1301626  0.602
2007 George O, Ghozland S, Azar MR, Cottone P, Zorrilla EP, Parsons LH, O'Dell LE, Richardson HN, Koob GF. CRF-CRF1 system activation mediates withdrawal-induced increases in nicotine self-administration in nicotine-dependent rats. Proceedings of the National Academy of Sciences of the United States of America. 104: 17198-203. PMID 17921249 DOI: 10.1073/Pnas.0707585104  0.814
2006 Lemaire V, Billard JM, Dutar P, George O, Piazza PV, Epelbaum J, Le Moal M, Mayo W. Motherhood-induced memory improvement persists across lifespan in rats but is abolished by a gestational stress. The European Journal of Neuroscience. 23: 3368-74. PMID 16820026 DOI: 10.1111/J.1460-9568.2006.04870.X  0.777
2006 Rabat A, Bouyer JJ, George O, Le Moal M, Mayo W. Chronic exposure of rats to noise: relationship between long-term memory deficits and slow wave sleep disturbances. Behavioural Brain Research. 171: 303-12. PMID 16716416 DOI: 10.1016/J.Bbr.2006.04.007  0.745
2006 George O, Vallée M, Le Moal M, Mayo W. Neurosteroids and cholinergic systems: implications for sleep and cognitive processes and potential role of age-related changes. Psychopharmacology. 186: 402-13. PMID 16416333 DOI: 10.1007/S00213-005-0254-6  0.733
2006 George O, Parducz A, Dupret D, Kharouby M, Le Moal M, Piazza PV, Mayo W. Smad-dependent alterations of PPT cholinergic neurons as a pathophysiological mechanism of age-related sleep-dependent memory impairments. Neurobiology of Aging. 27: 1848-58. PMID 16316709 DOI: 10.1016/J.Neurobiolaging.2005.10.014  0.772
2004 Vallée M, George O, Vitiello S, Le Moal M, Mayo W. New insights into the role of neuroactive steroids in cognitive aging. Experimental Gerontology. 39: 1695-704. PMID 15582285 DOI: 10.1016/J.Exger.2004.07.012  0.733
2004 Darbra S, George O, Bouyer JJ, Piazza PV, Le Moal M, Mayo W. Sleep-wake states and cortical synchronization control by pregnenolone sulfate into the pedunculopontine nucleus. Journal of Neuroscience Research. 76: 742-7. PMID 15139033 DOI: 10.1002/Jnr.20074  0.765
2003 Mayo W, George O, Darbra S, Bouyer JJ, Vallée M, Darnaudéry M, Pallarès M, Lemaire-Mayo V, Le Moal M, Piazza PV, Abrous N. Individual differences in cognitive aging: implication of pregnenolone sulfate. Progress in Neurobiology. 71: 43-8. PMID 14611866 DOI: 10.1016/J.Pneurobio.2003.09.006  0.773
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