Jerod S. Denton, Ph.D. - Publications

Affiliations: 
2002 Dartmouth College, Hanover, NH, United States 
Area:
Neuroscience Biology, Animal Physiology Biology

30 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2016 Swale DR, Kurata H, Kharade SV, Sheehan JH, Raphemot RR, Voigtritter KR, Figueroa E, Meiler J, Flobaum AL, Lindsley CW, Hopkins CR, Denton JS. ML418: The first selective, sub-micromolar pore blocker of Kir7.1 potassium channels. Acs Chemical Neuroscience. PMID 27184474 DOI: 10.1021/acschemneuro.6b00111  0.96
2016 Kharade SV, Nichols C, Denton JS. The shifting landscape of KATP channelopathies and the need for 'sharper' therapeutics. Future Medicinal Chemistry. PMID 27161588 DOI: 10.4155/fmc-2016-0005  0.96
2015 Herington JL, Swale DR, Brown N, Shelton EL, Choi H, Williams CH, Hong CC, Paria BC, Denton JS, Reese J. High-Throughput Screening of Myometrial Calcium-Mobilization to Identify Modulators of Uterine Contractility. Plos One. 10: e0143243. PMID 26600013 DOI: 10.1371/journal.pone.0143243  0.96
2015 Piermarini PM, Dunemann SM, Rouhier MF, Calkins TL, Raphemot R, Denton JS, Hine RM, Beyenbach KW. Localization and role of inward rectifier K(+) channels in Malpighian tubules of the yellow fever mosquito Aedes aegypti. Insect Biochemistry and Molecular Biology. 67: 59-73. PMID 26079629 DOI: 10.1016/j.ibmb.2015.06.006  0.96
2015 Kharade SV, Swale DR, Denton JS. ROMK (Kir1.1) pharmacology comes of age. Channels (Austin, Tex.). 9: 119-20. PMID 25941772 DOI: 10.1080/19336950.2015.1046733  0.96
2015 Swale DR, Sheehan JH, Banerjee S, Husni AS, Nguyen TT, Meiler J, Denton JS. Computational and functional analyses of a small-molecule binding site in ROMK. Biophysical Journal. 108: 1094-103. PMID 25762321 DOI: 10.1016/j.bpj.2015.01.022  0.96
2015 Ghamari-Langroudi M, Digby GJ, Sebag JA, Millhauser GL, Palomino R, Matthews R, Gillyard T, Panaro BL, Tough IR, Cox HM, Denton JS, Cone RD. G-protein-independent coupling of MC4R to Kir7.1 in hypothalamic neurons. Nature. 520: 94-8. PMID 25600267 DOI: 10.1038/nature14051  0.96
2014 Raphemot R, Rouhier MF, Swale DR, Days E, Weaver CD, Lovell KM, Konkel LC, Engers DW, Bollinger SR, Bollinger SF, Hopkins C, Piermarini PM, Denton JS. Discovery and characterization of a potent and selective inhibitor of Aedes aegypti inward rectifier potassium channels. Plos One. 9: e110772. PMID 25375326 DOI: 10.1371/journal.pone.0110772  0.96
2014 McCloskey C, Rada C, Bailey E, McCavera S, van den Berg HA, Atia J, Rand DA, Shmygol A, Chan YW, Quenby S, Brosens JJ, Vatish M, Zhang J, Denton JS, Taggart MJ, et al. The inwardly rectifying K+ channel KIR7.1 controls uterine excitability throughout pregnancy. Embo Molecular Medicine. 6: 1161-74. PMID 25056913 DOI: 10.15252/emmm.201403944  0.96
2014 Rouhier MF, Raphemot R, Denton JS, Piermarini PM. Pharmacological validation of an inward-rectifier potassium (Kir) channel as an insecticide target in the yellow fever mosquito Aedes aegypti. Plos One. 9: e100700. PMID 24959745 DOI: 10.1371/journal.pone.0100700  0.96
2014 Raphemot R, Estévez-Lao TY, Rouhier MF, Piermarini PM, Denton JS, Hillyer JF. Molecular and functional characterization of Anopheles gambiae inward rectifier potassium (Kir1) channels: a novel role in egg production. Insect Biochemistry and Molecular Biology. 51: 10-9. PMID 24855023 DOI: 10.1016/j.ibmb.2014.05.002  0.96
2014 Swale DR, Kharade SV, Denton JS. Cardiac and renal inward rectifier potassium channel pharmacology: emerging tools for integrative physiology and therapeutics. Current Opinion in Pharmacology. 15: 7-15. PMID 24721648 DOI: 10.1016/j.coph.2013.11.002  0.96
2014 Raphemot R, Swale DR, Dadi PK, Jacobson DA, Cooper P, Wojtovich AP, Banerjee S, Nichols CG, Denton JS. Direct activation of β-cell KATP channels with a novel xanthine derivative. Molecular Pharmacology. 85: 858-65. PMID 24646456 DOI: 10.1124/mol.114.091884  0.96
2014 Denton JS. Druggability of the inward rectifier family: a hope for rare channelopathies? Future Medicinal Chemistry. 6: 971-3. PMID 24547691 DOI: 10.4155/fmc.14.12  0.96
2013 Raphemot R, Kadakia RJ, Olsen ML, Banerjee S, Days E, Smith SS, Weaver CD, Denton JS. Development and validation of fluorescence-based and automated patch clamp-based functional assays for the inward rectifier potassium channel Kir4.1. Assay and Drug Development Technologies. 11: 532-43. PMID 24266659 DOI: 10.1089/adt.2013.544  0.96
2013 Bruehl S, Denton JS, Lonergan D, Koran ME, Chont M, Sobey C, Fernando S, Bush WS, Mishra P, Thornton-Wells TA. Associations between KCNJ6 (GIRK2) gene polymorphisms and pain-related phenotypes. Pain. 154: 2853-9. PMID 23994450 DOI: 10.1016/j.pain.2013.08.026  0.96
2013 Denton JS, Pao AC, Maduke M. Novel diuretic targets. American Journal of Physiology. Renal Physiology. 305: F931-42. PMID 23863472 DOI: 10.1152/ajprenal.00230.2013  0.96
2013 Raphemot R, Rouhier MF, Hopkins CR, Gogliotti RD, Lovell KM, Hine RM, Ghosalkar D, Longo A, Beyenbach KW, Denton JS, Piermarini PM. Eliciting renal failure in mosquitoes with a small-molecule inhibitor of inward-rectifying potassium channels. Plos One. 8: e64905. PMID 23734226 DOI: 10.1371/journal.pone.0064905  0.96
2013 Raphemot R, Weaver CD, Denton JS. High-throughput screening for small-molecule modulators of inward rectifier potassium channels. Journal of Visualized Experiments : Jove. PMID 23381507 DOI: 10.3791/4209  0.96
2012 Denton JS, Jacobson DA. Channeling dysglycemia: Ion-channel variations perturbing glucose homeostasis Trends in Endocrinology and Metabolism. 23: 41-48. PMID 22134088 DOI: 10.1016/j.tem.2011.09.004  0.96
2011 Raphemot R, Lonergan DF, Nguyen TT, Utley T, Lewis LM, Kadakia R, Weaver CD, Gogliotti R, Hopkins C, Lindsley CW, Denton JS. Discovery, characterization, and structure-activity relationships of an inhibitor of inward rectifier potassium (Kir) channels with preference for Kir2.3, Kir3.x, and Kir7.1. Frontiers in Pharmacology. 2: 75. PMID 22275899 DOI: 10.3389/fphar.2011.00075  0.96
2011 Bhave G, Chauder BA, Liu W, Dawson ES, Kadakia R, Nguyen TT, Lewis LM, Meiler J, Weaver CD, Satlin LM, Lindsley CW, Denton JS. Development of a selective small-molecule inhibitor of Kir1.1, the renal outer medullary potassium channel. Molecular Pharmacology. 79: 42-50. PMID 20926757 DOI: 10.1124/mol.110.066928  0.96
2010 Bhave G, Lonergan D, Chauder BA, Denton JS. Small-molecule modulators of inward rectifier K+ channels: recent advances and future possibilities. Future Medicinal Chemistry. 2: 757-74. PMID 20543968 DOI: 10.4155/fmc.10.179  0.96
2009 Lewis LM, Bhave G, Chauder BA, Banerjee S, Lornsen KA, Redha R, Fallen K, Lindsley CW, Weaver CD, Denton JS. High-throughput screening reveals a small-molecule inhibitor of the renal outer medullary potassium channel and Kir7.1. Molecular Pharmacology. 76: 1094-103. PMID 19706730 DOI: 10.1124/mol.109.059840  0.96
2009 Fallen K, Banerjee S, Sheehan J, Addison D, Lewis LM, Meiler J, Denton JS. The Kir channel immunoglobulin domain is essential for Kir1.1 (ROMK) thermodynamic stability, trafficking and gating. Channels (Austin, Tex.). 3: 57-68. PMID 19221509  0.96
2007 Denton JS, McCann FV, Leiter JC. CO2 chemosensitivity in Helix aspersa: three potassium currents mediate pH-sensitive neuronal spike timing. American Journal of Physiology. Cell Physiology. 292: C292-304. PMID 16928774 DOI: 10.1152/ajpcell.00172.2006  0.96
2007 Chernov MM, Daubenspeck JA, Denton JS, Pfeiffer JR, Putnam RW, Leiter JC. A computational analysis of central CO2 chemosensitivity in Helix aspersa. American Journal of Physiology. Cell Physiology. 292: C278-91. PMID 16928773 DOI: 10.1152/ajpcell.00173.2006  0.96
2002 Denton JS, Leiter JC. Anomalous effects of external TEA on permeation and gating of the A-type potassium current in H. aspersa neuronal somata. The Journal of Membrane Biology. 190: 17-28. PMID 12422269 DOI: 10.1007/s00232-002-1021-9  0.96
1999 Chalfant ML, Denton JS, Langloh AL, Karlson KH, Loffing J, Benos DJ, Stanton BA. The NH(2) terminus of the epithelial sodium channel contains an endocytic motif. The Journal of Biological Chemistry. 274: 32889-96. PMID 10551853 DOI: 10.1074/jbc.274.46.32889  0.96
1999 Chalfant ML, Denton JS, Berdiev BK, Ismailov II, Benos DJ, Stanton BA. Intracellular H+ regulates the α-subunit of ENaC, the epithelial Na+ channel American Journal of Physiology - Cell Physiology. 276. PMID 9950776  0.96
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