Dario DiFrancesco - Publications

Affiliations: 
Università degli studi di Milano, Italy, Milano, Lombardia, Italy 
Area:
Ih channels

155 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2016 Baruscotti M, Bianco E, Bucchi A, DiFrancesco D. Current understanding of the pathophysiological mechanisms responsible for inappropriate sinus tachycardia: role of the If "funny" current. Journal of Interventional Cardiac Electrophysiology : An International Journal of Arrhythmias and Pacing. PMID 26781742 DOI: 10.1007/s10840-015-0097-y  1
2015 Ravagli E, Bucchi A, Bartolucci C, Paina M, Baruscotti M, DiFrancesco D, Severi S. Cell-specific Dynamic Clamp analysis of the role of funny If current in cardiac pacemaking. Progress in Biophysics and Molecular Biology. PMID 26718599 DOI: 10.1016/j.pbiomolbio.2015.12.004  1
2015 DiFrancesco JC, DiFrancesco D. Dysfunctional HCN ion channels in neurological diseases. Frontiers in Cellular Neuroscience. 6: 174. PMID 25805968 DOI: 10.3389/fncel.2015.00071  1
2014 D'Souza A, Bucchi A, Johnsen AB, Logantha SJ, Monfredi O, Yanni J, Prehar S, Hart G, Cartwright E, Wisloff U, Dobryznski H, DiFrancesco D, Morris GM, Boyett MR. Exercise training reduces resting heart rate via downregulation of the funny channel HCN4. Nature Communications. 5: 3775. PMID 24825544 DOI: 10.1038/ncomms4775  1
2014 Lolicato M, Bucchi A, Arrigoni C, Zucca S, Nardini M, Schroeder I, Simmons K, Aquila M, DiFrancesco D, Bolognesi M, Schwede F, Kashin D, Fishwick CW, Johnson AP, Thiel G, et al. Cyclic dinucleotides bind the C-linker of HCN4 to control channel cAMP responsiveness. Nature Chemical Biology. 10: 457-62. PMID 24776929 DOI: 10.1038/nchembio.1521  1
2014 Barbuti A, DiFrancesco D. The 'funny' side of sepsis. The Journal of Physiology. 592: 1171. PMID 24634015 DOI: 10.1113/jphysiol.2014.271171  1
2014 Noble D, Difrancesco D, Zancani D. Leonardo da Vinci and the origin of semen Notes and Records of the Royal Society. 68: 391-402. DOI: 10.1098/rsnr.2014.0021  1
2013 Difrancesco D, Nawathe PA, Robinson RB. Multifactorial impact of channel beta-subunit gene mutation on automaticity. Journal of Cardiovascular Electrophysiology. 24: E26-7. PMID 24015862 DOI: 10.1111/jce.12235  1
2013 Scavone A, Capilupo D, Mazzocchi N, Crespi A, Zoia S, Campostrini G, Bucchi A, Milanesi R, Baruscotti M, Benedetti S, Antonini S, Messina G, DiFrancesco D, Barbuti A. Embryonic stem cell-derived CD166+ precursors develop into fully functional sinoatrial-like cells. Circulation Research. 113: 389-98. PMID 23753573 DOI: 10.1161/CIRCRESAHA.113.301283  1
2013 Nawathe PA, Kryukova Y, Oren RV, Milanesi R, Clancy CE, Lu JT, Moss AJ, Difrancesco D, Robinson RB. An LQTS6 MiRP1 mutation suppresses pacemaker current and is associated with sinus bradycardia. Journal of Cardiovascular Electrophysiology. 24: 1021-7. PMID 23631727 DOI: 10.1111/jce.12163  1
2013 DiFrancesco D. Funny channel gene mutations associated with arrhythmias. The Journal of Physiology. 591: 4117-24. PMID 23507880 DOI: 10.1113/jphysiol.2013.253765  1
2013 Bucchi A, Baruscotti M, Nardini M, Barbuti A, Micheloni S, Bolognesi M, DiFrancesco D. Identification of the molecular site of ivabradine binding to HCN4 channels. Plos One. 8: e53132. PMID 23308150 DOI: 10.1371/journal.pone.0053132  1
2012 Vecellio M, Meraviglia V, Nanni S, Barbuti A, Scavone A, DiFrancesco D, Farsetti A, Pompilio G, Colombo GI, Capogrossi MC, Gaetano C, Rossini A. In vitro epigenetic reprogramming of human cardiac mesenchymal stromal cells into functionally competent cardiovascular precursors. Plos One. 7: e51694. PMID 23284745 DOI: 10.1371/journal.pone.0051694  1
2012 Bucchi A, Barbuti A, Difrancesco D, Baruscotti M. Funny Current and Cardiac Rhythm: Insights from HCN Knockout and Transgenic Mouse Models. Frontiers in Physiology. 3: 240. PMID 22783204 DOI: 10.3389/fphys.2012.00240  1
2012 Severi S, Fantini M, Charawi LA, DiFrancesco D. An updated computational model of rabbit sinoatrial action potential to investigate the mechanisms of heart rate modulation. The Journal of Physiology. 590: 4483-99. PMID 22711956 DOI: 10.1113/jphysiol.2012.229435  1
2012 Barbuti A, Scavone A, Mazzocchi N, Terragni B, Baruscotti M, Difrancesco D. A caveolin-binding domain in the HCN4 channels mediates functional interaction with caveolin proteins. Journal of Molecular and Cellular Cardiology. 53: 187-95. PMID 22659290 DOI: 10.1016/j.yjmcc.2012.05.013  1
2012 DiFrancesco D, Noble D. Rebuttal: "The funny current in the context of the coupled clock pacemaker cell system". Heart Rhythm : the Official Journal of the Heart Rhythm Society. 9: 457-8. PMID 21925135 DOI: 10.1016/j.hrthm.2011.09.023  1
2012 DiFrancesco D, Noble D. The funny current has a major pacemaking role in the sinus node. Heart Rhythm : the Official Journal of the Heart Rhythm Society. 9: 299-301. PMID 21925134 DOI: 10.1016/j.hrthm.2011.09.021  1
2011 DiFrancesco JC, Barbuti A, Milanesi R, Coco S, Bucchi A, Bottelli G, Ferrarese C, Franceschetti S, Terragni B, Baruscotti M, DiFrancesco D. Recessive loss-of-function mutation in the pacemaker HCN2 channel causing increased neuronal excitability in a patient with idiopathic generalized epilepsy. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 31: 17327-37. PMID 22131395 DOI: 10.1523/JNEUROSCI.3727-11.2011  1
2011 Quinn TA, Granite S, Allessie MA, Antzelevitch C, Bollensdorff C, Bub G, Burton RA, Cerbai E, Chen PS, Delmar M, Difrancesco D, Earm YE, Efimov IR, Egger M, Entcheva E, et al. Minimum Information about a Cardiac Electrophysiology Experiment (MICEE): standardised reporting for model reproducibility, interoperability, and data sharing. Progress in Biophysics and Molecular Biology. 107: 4-10. PMID 21745496 DOI: 10.1016/j.pbiomolbio.2011.07.001  1
2011 Avitabile D, Crespi A, Brioschi C, Parente V, Toietta G, Devanna P, Baruscotti M, Truffa S, Scavone A, Rusconi F, Biondi A, D'Alessandra Y, Vigna E, Difrancesco D, Pesce M, et al. Human cord blood CD34+ progenitor cells acquire functional cardiac properties through a cell fusion process. American Journal of Physiology. Heart and Circulatory Physiology. 300: H1875-84. PMID 21357510 DOI: 10.1152/ajpheart.00523.2010  1
2011 Baruscotti M, Bucchi A, Viscomi C, Mandelli G, Consalez G, Gnecchi-Rusconi T, Montano N, Casali KR, Micheloni S, Barbuti A, DiFrancesco D. Deep bradycardia and heart block caused by inducible cardiac-specific knockout of the pacemaker channel gene Hcn4. Proceedings of the National Academy of Sciences of the United States of America. 108: 1705-10. PMID 21220308 DOI: 10.1073/pnas.1010122108  1
2011 Rossini A, Frati C, Lagrasta C, Graiani G, Scopece A, Cavalli S, Musso E, Baccarin M, Di Segni M, Fagnoni F, Germani A, Quaini E, Mayr M, Xu Q, Barbuti A, ... DiFrancesco D, et al. Human cardiac and bone marrow stromal cells exhibit distinctive properties related to their origin. Cardiovascular Research. 89: 650-60. PMID 20833652 DOI: 10.1093/cvr/cvq290  1
2011 Pisoni G, D'Amelio P, Sassi F, Manarolla G, Scaccabarozzi L, Locatelli C, Mazzocchi N, Baruscotti M, DiFrancesco D, Moroni P. Multinucleated giant cells with an osteoclast phenotype derived from caprine peripheral blood mononuclear cells. Veterinary Journal (London, England : 1997). 189: 361-3. PMID 20822938 DOI: 10.1016/j.tvjl.2010.07.016  1
2010 Baruscotti M, Bottelli G, Milanesi R, DiFrancesco JC, DiFrancesco D. HCN-related channelopathies. PflüGers Archiv : European Journal of Physiology. 460: 405-15. PMID 20213494 DOI: 10.1007/s00424-010-0810-8  1
2010 DiFrancesco D. The role of the funny current in pacemaker activity. Circulation Research. 106: 434-46. PMID 20167941 DOI: 10.1161/CIRCRESAHA.109.208041  1
2010 DiFrancesco D. Funny channel-based pacemaking. Heart Rhythm : the Official Journal of the Heart Rhythm Society. 7: 276-9. PMID 20022815 DOI: 10.1016/j.hrthm.2009.10.030  1
2010 Barbuti A, Galvez BG, Crespi A, Scavone A, Baruscotti M, Brioschi C, Cossu G, DiFrancesco D. Mesoangioblasts from ventricular vessels can differentiate in vitro into cardiac myocytes with sinoatrial-like properties. Journal of Molecular and Cellular Cardiology. 48: 415-23. PMID 19837079 DOI: 10.1016/j.yjmcc.2009.10.006  1
2010 DiFrancesco D. Considerations on the size of currents required for pacemaking Journal of Molecular and Cellular Cardiology. 48: 802-803. DOI: 10.1016/j.yjmcc.2009.11.022  1
2010 Barbuti A, Bucchi A, Baruscotti M, Difrancesco D. The "Funny" Pacemaker Current Novel Therapeutic Targets For Antiarrhythmic Drugs. 59-99. DOI: 10.1002/9780470561416.ch3  1
2009 DiFrancesco D. More seafood to control heart rate? Heart Rhythm : the Official Journal of the Heart Rhythm Society. 6: 1493-4. PMID 19968930 DOI: 10.1016/j.hrthm.2009.08.019  1
2009 Brioschi C, Micheloni S, Tellez JO, Pisoni G, Longhi R, Moroni P, Billeter R, Barbuti A, Dobrzynski H, Boyett MR, DiFrancesco D, Baruscotti M. Distribution of the pacemaker HCN4 channel mRNA and protein in the rabbit sinoatrial node. Journal of Molecular and Cellular Cardiology. 47: 221-7. PMID 19394343 DOI: 10.1016/j.yjmcc.2009.04.009  1
2009 Lakatta EG, DiFrancesco D. What keeps us ticking: a funny current, a calcium clock, or both? Journal of Molecular and Cellular Cardiology. 47: 157-70. PMID 19361514 DOI: 10.1016/j.yjmcc.2009.03.022  1
2009 Chandler NJ, Greener ID, Tellez JO, Inada S, Musa H, Molenaar P, Difrancesco D, Baruscotti M, Longhi R, Anderson RH, Billeter R, Sharma V, Sigg DC, Boyett MR, Dobrzynski H. Molecular architecture of the human sinus node: insights into the function of the cardiac pacemaker. Circulation. 119: 1562-75. PMID 19289639 DOI: 10.1161/CIRCULATIONAHA.108.804369  1
2009 Barbuti A, Crespi A, Capilupo D, Mazzocchi N, Baruscotti M, DiFrancesco D. Molecular composition and functional properties of f-channels in murine embryonic stem cell-derived pacemaker cells. Journal of Molecular and Cellular Cardiology. 46: 343-51. PMID 19135060 DOI: 10.1016/j.yjmcc.2008.12.001  1
2008 Galvez BG, Sampaolesi M, Barbuti A, Crespi A, Covarello D, Brunelli S, Dellavalle A, Crippa S, Balconi G, Cuccovillo I, Molla F, Staszewsky L, Latini R, Difrancesco D, Cossu G. Cardiac mesoangioblasts are committed, self-renewable progenitors, associated with small vessels of juvenile mouse ventricle. Cell Death and Differentiation. 15: 1417-28. PMID 18497758 DOI: 10.1038/cdd.2008.75  1
2008 Barbuti A, DiFrancesco D. Control of cardiac rate by "funny" channels in health and disease. Annals of the New York Academy of Sciences. 1123: 213-23. PMID 18375593 DOI: 10.1196/annals.1420.024  1
2007 DiFrancesco D, Borer JS. The funny current: cellular basis for the control of heart rate. Drugs. 67: 15-24. PMID 17999560  1
2007 Bucchi A, Baruscotti M, Robinson RB, DiFrancesco D. Modulation of rate by autonomic agonists in SAN cells involves changes in diastolic depolarization and the pacemaker current. Journal of Molecular and Cellular Cardiology. 43: 39-48. PMID 17543331 DOI: 10.1016/j.yjmcc.2007.04.017  1
2007 Barbuti A, Baruscotti M, DiFrancesco D. The pacemaker current: from basics to the clinics. Journal of Cardiovascular Electrophysiology. 18: 342-7. PMID 17284289 DOI: 10.1111/j.1540-8167.2006.00736.x  1
2007 Bucchi A, Barbuti A, Baruscotti M, DiFrancesco D. Heart rate reduction via selective 'funny' channel blockers. Current Opinion in Pharmacology. 7: 208-13. PMID 17267284 DOI: 10.1016/j.coph.2006.09.005  1
2007 Barbuti A, Terragni B, Brioschi C, DiFrancesco D. Localization of f-channels to caveolae mediates specific beta2-adrenergic receptor modulation of rate in sinoatrial myocytes. Journal of Molecular and Cellular Cardiology. 42: 71-8. PMID 17070839 DOI: 10.1016/j.yjmcc.2006.09.018  1
2006 DiFrancesco D. Funny channels in the control of cardiac rhythm and mode of action of selective blockers. Pharmacological Research : the Official Journal of the Italian Pharmacological Society. 53: 399-406. PMID 16638640 DOI: 10.1016/j.phrs.2006.03.006  1
2006 Bucchi A, Tognati A, Milanesi R, Baruscotti M, DiFrancesco D. Properties of ivabradine-induced block of HCN1 and HCN4 pacemaker channels. The Journal of Physiology. 572: 335-46. PMID 16484306 DOI: 10.1113/jphysiol.2005.100776  1
2006 Milanesi R, Baruscotti M, Gnecchi-Ruscone T, DiFrancesco D. Familial sinus bradycardia associated with a mutation in the cardiac pacemaker channel. The New England Journal of Medicine. 354: 151-7. PMID 16407510 DOI: 10.1056/NEJMoa052475  1
2006 DiFrancesco D. Serious workings of the funny current. Progress in Biophysics and Molecular Biology. 90: 13-25. PMID 15975637 DOI: 10.1016/j.pbiomolbio.2005.05.001  1
2005 DiFrancesco D. Letter regarding article by Michels et al, "Single-channel properties support a potential contribution of hyperpolarization-activated cyclic nucleotide-gated channels and If to cardiac arrhythmias". Circulation. 112: e72; author reply e7. PMID 16061749 DOI: 10.1161/CIRCULATIONAHA.105.541367  1
2005 DiFrancesco D. Cardiac pacemaker I(f) current and its inhibition by heart rate-reducing agents. Current Medical Research and Opinion. 21: 1115-22. PMID 16004681 DOI: 10.1185/030079905X50543  1
2005 Baruscotti M, Bucchi A, Difrancesco D. Physiology and pharmacology of the cardiac pacemaker ("funny") current. Pharmacology & Therapeutics. 107: 59-79. PMID 15963351 DOI: 10.1016/j.pharmthera.2005.01.005  1
2004 DiFrancesco D, Camm JA. Heart rate lowering by specific and selective I(f) current inhibition with ivabradine: a new therapeutic perspective in cardiovascular disease. Drugs. 64: 1757-65. PMID 15301560 DOI: 10.2165/00003495-200464160-00003  1
2004 Gravante B, Barbuti A, Milanesi R, Zappi I, Viscomi C, DiFrancesco D. Interaction of the pacemaker channel HCN1 with filamin A. The Journal of Biological Chemistry. 279: 43847-53. PMID 15292205 DOI: 10.1074/jbc.M401598200  1
2004 Baruscotti M, Difrancesco D. Pacemaker channels. Annals of the New York Academy of Sciences. 1015: 111-21. PMID 15201153 DOI: 10.1196/annals.1302.009  1
2004 Gazzarrini S, Kang M, Van Etten JL, Tayefeh S, Kast SM, DiFrancesco D, Thiel G, Moroni A. Long distance interactions within the potassium channel pore are revealed by molecular diversity of viral proteins. The Journal of Biological Chemistry. 279: 28443-9. PMID 15105432 DOI: 10.1074/jbc.M401184200  1
2004 Barbuti A, Gravante B, Riolfo M, Milanesi R, Terragni B, DiFrancesco D. Localization of pacemaker channels in lipid rafts regulates channel kinetics. Circulation Research. 94: 1325-31. PMID 15073040 DOI: 10.1161/01.RES.0000127621.54132.AE  1
2004 Kang M, Moroni A, Gazzarrini S, DiFrancesco D, Thiel G, Severino M, Van Etten JL. Small potassium ion channel proteins encoded by chlorella viruses. Proceedings of the National Academy of Sciences of the United States of America. 101: 5318-24. PMID 14762169 DOI: 10.1073/pnas.0307824100  1
2004 DiFrancesco D. Pacemaker Channels and Normal Automaticity Cardiac Electrophysiology: Fourth Edition. 103-111. DOI: 10.1016/B0-7216-0323-8/50015-4  1
2003 Robinson RB, Baruscotti M, DiFrancesco D. Autonomic modulation of heart rate: pitfalls of nonselective channel blockade. American Journal of Physiology. Heart and Circulatory Physiology. 285: H2865; author reply . PMID 14613917 DOI: 10.1152/ajpheart.00545.2003  1
2003 Gazzarrini S, Severino M, Lombardi M, Morandi M, DiFrancesco D, Van Etten JL, Thiel G, Moroni A. The viral potassium channel Kcv: structural and functional features. Febs Letters. 552: 12-6. PMID 12972145 DOI: 10.1016/S0014-5793(03)00777-4  1
2003 Bucchi A, Baruscotti M, Robinson RB, DiFrancesco D. I(f)-dependent modulation of pacemaker rate mediated by cAMP in the presence of ryanodine in rabbit sino-atrial node cells. Journal of Molecular and Cellular Cardiology. 35: 905-13. PMID 12878477 DOI: 10.1016/S0022-2828(03)00150-0  1
2003 Altomare C, Terragni B, Brioschi C, Milanesi R, Pagliuca C, Viscomi C, Moroni A, Baruscotti M, DiFrancesco D. Heteromeric HCN1-HCN4 channels: a comparison with native pacemaker channels from the rabbit sinoatrial node. The Journal of Physiology. 549: 347-59. PMID 12702747 DOI: 10.1113/jphysiol.2002.027698  1
2003 DiFrancesco D. If inhibition: A novel mechanism of action European Heart Journal, Supplement. 5: G19-G25. DOI: 10.1016/S1520-765X(03)90004-6  1
2002 Moroni A, Viscomi C, Sangiorgio V, Pagliuca C, Meckel T, Horvath F, Gazzarrini S, Valbuzzi P, Van Etten JL, DiFrancesco D, Thiel G. The short N-terminus is required for functional expression of the virus-encoded miniature K(+) channel Kcv. Febs Letters. 530: 65-9. PMID 12387867 DOI: 10.1016/S0014-5793(02)03397-5  1
2002 Qu J, Altomare C, Bucchi A, DiFrancesco D, Robinson RB. Functional comparison of HCN isoforms expressed in ventricular and HEK 293 cells. PflüGers Archiv : European Journal of Physiology. 444: 597-601. PMID 12194012 DOI: 10.1007/s00424-002-0860-7  1
2002 Demontis GC, Moroni A, Gravante B, Altomare C, Longoni B, Cervetto L, DiFrancesco D. Functional characterisation and subcellular localisation of HCN1 channels in rabbit retinal rod photoreceptors. The Journal of Physiology. 542: 89-97. PMID 12096053 DOI: 10.1113/jphysiol.2002.017640  1
2002 Bucchi A, Baruscotti M, DiFrancesco D. Current-dependent block of rabbit sino-atrial node I(f) channels by ivabradine. The Journal of General Physiology. 120: 1-13. PMID 12084770 DOI: 10.1085/jgp.20028593  1
2002 Gazzarrini S, Etten JL, DiFrancesco D, Thiel G, Moroni A. Voltage-dependence of virus-encoded miniature K+ channel Kcv. The Journal of Membrane Biology. 187: 15-25. PMID 12029374 DOI: 10.1007/s00232-001-0147-5  1
2002 DiFrancesco D, Robinson RB. beta-modulation of pacemaker rate: novel mechanism or novel mechanics of an old one? Circulation Research. 90: E69-9. PMID 11934845  1
2002 Accili EA, Proenza C, Baruscotti M, DiFrancesco D. From funny current to HCN channels: 20 years of excitation. News in Physiological Sciences : An International Journal of Physiology Produced Jointly by the International Union of Physiological Sciences and the American Physiological Society. 17: 32-7. PMID 11821534  1
2001 Protas L, DiFrancesco D, Robinson RB. L-type but not T-type calcium current changes during postnatal development in rabbit sinoatrial node. American Journal of Physiology. Heart and Circulatory Physiology. 281: H1252-9. PMID 11514294  1
2001 Baruscotti M, DiFrancesco D, Robinson RB. Single-channel properties of the sinoatrial node Na+ current in the newborn rabbit. PflüGers Archiv : European Journal of Physiology. 442: 192-6. PMID 11417213 DOI: 10.1007/s004240100527  1
2001 Viscomi C, Altomare C, Bucchi A, Camatini E, Baruscotti M, Moroni A, DiFrancesco D. C terminus-mediated control of voltage and cAMP gating of hyperpolarization-activated cyclic nucleotide-gated channels. The Journal of Biological Chemistry. 276: 29930-4. PMID 11397812 DOI: 10.1074/jbc.M103971200  1
2001 Altomare C, Bucchi A, Camatini E, Baruscotti M, Viscomi C, Moroni A, DiFrancesco D. Integrated allosteric model of voltage gating of HCN channels. The Journal of General Physiology. 117: 519-32. PMID 11382803 DOI: 10.1085/jgp.117.6.519  1
2001 Moroni A, Gorza L, Beltrame M, Gravante B, Vaccari T, Bianchi ME, Altomare C, Longhi R, Heurteaux C, Vitadello M, Malgaroli A, DiFrancesco D. Hyperpolarization-activated cyclic nucleotide-gated channel 1 is a molecular determinant of the cardiac pacemaker current I(f). The Journal of Biological Chemistry. 276: 29233-41. PMID 11328811 DOI: 10.1074/jbc.M100830200  1
2001 DiFrancesco DT. Senate passes health care reform package. New Jersey Medicine : the Journal of the Medical Society of New Jersey. 98: 17-8. PMID 11198108  1
2000 Baruscotti M, DiFrancesco D, Robinson RB. Na(+) current contribution to the diastolic depolarization in newborn rabbit SA node cells. American Journal of Physiology. Heart and Circulatory Physiology. 279: H2303-9. PMID 11045966  1
2000 Altomare C, Barbuti A, Viscomi C, Baruscotti M, DiFrancesco D. Effects of dronedarone on acetylcholine-activated current in rabbit SAN cells. British Journal of Pharmacology. 130: 1315-20. PMID 10903971 DOI: 10.1038/sj.bjp.0703446  1
2000 DiFrancesco DT. Comprehensive health care review is legislative priority. New Jersey Medicine : the Journal of the Medical Society of New Jersey. 97: 27-8. PMID 10832362  1
2000 Moroni A, Barbuti A, Altomare C, Viscomi C, Morgan J, Baruscotti M, DiFrancesco D. Kinetic and ionic properties of the human HCN2 pacemaker channel. PflüGers Archiv : European Journal of Physiology. 439: 618-26. PMID 10764222 DOI: 10.1007/s004240050985  1
2000 Moroni A, Gazzarrini S, Cerana R, Colombo R, Sutter JU, DiFrancesco D, Gradmann D, Thiel G. Mutation in pore domain uncovers cation- and voltage-sensitive recovery from inactivation in KAT1 channel. Biophysical Journal. 78: 1862-71. PMID 10733966 DOI: 10.1016/S0006-3495(00)76735-X  1
2000 Plugge B, Gazzarrini S, Nelson M, Cerana R, Van Etten JL, Derst C, DiFrancesco D, Moroni A, Thiel G. A potassium channel protein encoded by chlorella virus PBCV-1. Science (New York, N.Y.). 287: 1641-4. PMID 10698737 DOI: 10.1126/science.287.5458.1641  1
1999 Barbuti A, Baruscotti M, Altomare C, Moroni A, DiFrancesco D. Action of internal pronase on the f-channel kinetics in the rabbit SA node. The Journal of Physiology. 520: 737-44. PMID 10545140 DOI: 10.1111/j.1469-7793.1999.00737.x  1
1999 Vaccari T, Moroni A, Rocchi M, Gorza L, Bianchi ME, Beltrame M, DiFrancesco D. The human gene coding for HCN2, a pacemaker channel of the heart. Biochimica Et Biophysica Acta. 1446: 419-25. PMID 10524219 DOI: 10.1016/S0167-4781(99)00092-5  1
1999 Gasparini S, DiFrancesco D. Action of serotonin on the hyperpolarization-activated cation current (Ih) in rat CA1 hippocampal neurons. The European Journal of Neuroscience. 11: 3093-100. PMID 10510173 DOI: 10.1046/j.1460-9568.1999.00728.x  1
1999 DiFrancesco D. Dual allosteric modulation of pacemaker (f) channels by cAMP and voltage in rabbit SA node. The Journal of Physiology. 515: 367-76. PMID 10050004  1
1998 Accili EA, Redaelli G, DiFrancesco D. Two distinct pathways of muscarinic current responses in rabbit sino-atrial node myocytes. PflüGers Archiv : European Journal of Physiology. 437: 164-7. PMID 9817803 DOI: 10.1007/s004240050763  1
1997 Gasparini S, DiFrancesco D. Action of the hyperpolarization-activated current (Ih) blocker ZD 7288 in hippocampal CA1 neurons. PflüGers Archiv : European Journal of Physiology. 435: 99-106. PMID 9359908 DOI: 10.1007/s004240050488  1
1997 Bois P, Renaudon B, Baruscotti M, Lenfant J, DiFrancesco D. Activation of f-channels by cAMP analogues in macropatches from rabbit sino-atrial node myocytes. The Journal of Physiology. 501: 565-71. PMID 9218217 DOI: 10.1111/j.1469-7793.1997.565bm.x  1
1997 Accili EA, Redaelli G, DiFrancesco D. Differential control of the hyperpolarization-activated current (i(f)) by cAMP gating and phosphatase inhibition in rabbit sino-atrial node myocytes. The Journal of Physiology. 500: 643-51. PMID 9161982  1
1997 Janigro D, Gasparini S, D'Ambrosio R, McKhann G, DiFrancesco D. Reduction of K+ uptake in glia prevents long-term depression maintenance and causes epileptiform activity. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 17: 2813-24. PMID 9092603  1
1997 Accili EA, Robinson RB, DiFrancesco D. Properties and modulation of If in newborn versus adult cardiac SA node. The American Journal of Physiology. 272: H1549-52. PMID 9087633  1
1997 Baruscotti M, Westenbroek R, Catterall WA, DiFrancesco D, Robinson RB. The newborn rabbit sino-atrial node expresses a neuronal type I-like Na+ channel. The Journal of Physiology. 498: 641-8. PMID 9051576  1
1996 Zaza A, Robinson RB, DiFrancesco D. Basal responses of the L-type Ca2+ and hyperpolarization-activated currents to autonomic agonists in the rabbit sino-atrial node. The Journal of Physiology. 491: 347-55. PMID 8866859  1
1996 Zaza A, Rocchetti M, DiFrancesco D. Modulation of the hyperpolarization-activated current (I(f)) by adenosine in rabbit sinoatrial myocytes. Circulation. 94: 734-41. PMID 8772696  1
1996 Baruscotti M, DiFrancesco D, Robinson RB. A TTX-sensitive inward sodium current contributes to spontaneous activity in newborn rabbit sino-atrial node cells. The Journal of Physiology. 492: 21-30. PMID 8730579  1
1996 Mazzanti M, Assandri R, Ferroni A, DiFrancesco D. Cytoskeletal control of rectification and expression of four substates in cardiac inward rectifier K+ channels. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 10: 357-61. PMID 8641571  1
1996 Accili EA, Redaelli G, DiFrancesco D. Activation of the hyperpolarization-activated current (if) in sino-atrial node myocytes of the rabbit by vasoactive intestinal peptide. PflüGers Archiv : European Journal of Physiology. 431: 803-5. PMID 8596736 DOI: 10.1007/BF02253849  1
1996 Accili EA, DiFrancesco D. Inhibition of the hyperpolarization-activated current (if) of rabbit SA node myocytes by niflumic acid. PflüGers Archiv : European Journal of Physiology. 431: 757-62. PMID 8596727 DOI: 10.1007/BF02253840  1
1995 DiFrancesco D. Cardiac pacemaker: 15 years of "new" interpretation. Acta Cardiologica. 50: 413-27. PMID 8932564  1
1995 DiFrancesco D. Cesium and the pacemaker current. Journal of Cardiovascular Electrophysiology. 6: 1152-5. PMID 8720217  1
1995 DiFrancesco D. The pacemaker current (I(f)) plays an important role in regulating SA node pacemaker activity. Cardiovascular Research. 30: 307-8. PMID 7585819 DOI: 10.1016/S0008-6363(95)00029-1  1
1995 DiFrancesco D. The onset and autonomic regulation of cardiac pacemaker activity: relevance of the f current. Cardiovascular Research. 29: 449-56. PMID 7540954 DOI: 10.1016/0008-6363(96)88518-X  1
1994 DiFrancesco D. Some properties of the UL-FS 49 block of the hyperpolarization-activated current (i(f)) in sino-atrial node myocytes. PflüGers Archiv : European Journal of Physiology. 427: 64-70. PMID 8058476 DOI: 10.1007/BF00585943  1
1994 Maccaferri G, Janigro D, Lazzari A, DiFrancesco D. Cesium prevents maintenance of long-term depression in rat hippocampal CA1 neurons. Neuroreport. 5: 1813-6. PMID 7827339  1
1994 DiFrancesco D, Mangoni M. Modulation of single hyperpolarization-activated channels (i(f)) by cAMP in the rabbit sino-atrial node. The Journal of Physiology. 474: 473-82. PMID 7516974  1
1993 Hundal SP, DiFrancesco D, Mangoni M, Brammar WJ, Conley EC. An isoform of the cGMP-gated retinal photoreceptor channel gene expressed in the sinoatrial node (pacemaker) region of rabbit heart. Biochemical Society Transactions. 21: 119S. PMID 8359375  1
1993 Maccaferri G, Mangoni M, Lazzari A, DiFrancesco D. Properties of the hyperpolarization-activated current in rat hippocampal CA1 pyramidal cells. Journal of Neurophysiology. 69: 2129-36. PMID 7688802  1
1993 DiFrancesco D. Pacemaker mechanisms in cardiac tissue. Annual Review of Physiology. 55: 455-72. PMID 7682045 DOI: 10.1146/annurev.ph.55.030193.002323  1
1992 DiFrancesco D, Ducouret P, Robinson R. Differential effects of ACh on cardiac pacemaker cells. Trends in Neurosciences. 15: 249-50. PMID 1381117 DOI: 10.1016/0166-2236(92)90059-H  1
1992 Noble D, Denyer JC, Brown HF, DiFrancesco D. Reciprocal role of the inward currents ib, Na and i(f) in controlling and stabilizing pacemaker frequency of rabbit sino-atrial node cells. Proceedings. Biological Sciences / the Royal Society. 250: 199-207. PMID 1283636 DOI: 10.1098/rspb.1992.0150  1
1992 DiFrancesco D, Zaza A. The cardiac pacemaker current i(f) Journal of Cardiovascular Electrophysiology. 3: 334-344.  1
1991 Difrancesco D. Generation and control of cardiac pacing the pacemaker current. Trends in Cardiovascular Medicine. 1: 250-5. PMID 21239304 DOI: 10.1016/1050-1738(91)90030-I  1
1991 DiFrancesco D, Porciatti F, Janigro D, Maccaferri G, Mangoni M, Tritella T, Chang F, Cohen IS. Block of the cardiac pacemaker current (If) in the rabbit sino-atrial node and in canine Purkinje fibres by 9-amino-1,2,3,4-tetrahydroacridine. PflüGers Archiv : European Journal of Physiology. 417: 611-5. PMID 2057325 DOI: 10.1007/BF00372959  1
1991 DiFrancesco D, Porciatti F, Cohen IS. The effects of manganese and barium on the cardiac pacemaker current, if, in rabbit sino-atrial node myocytes. Experientia. 47: 449-52. PMID 2044699 DOI: 10.1007/BF01959940  1
1991 DiFrancesco D. The contribution of the 'pacemaker' current (if) to generation of spontaneous activity in rabbit sino-atrial node myocytes. The Journal of Physiology. 434: 23-40. PMID 2023118  1
1991 Chang F, Cohen IS, DiFrancesco D, Rosen MR, Tromba C. Effects of protein kinase inhibitors on canine Purkinje fibre pacemaker depolarization and the pacemaker current i(f). The Journal of Physiology. 440: 367-84. PMID 1804968  1
1991 Zaza A, Maccaferri G, Mangoni M, DiFrancesco D. Intracellular calcium does not directly modulate cardiac pacemaker (if) channels. PflüGers Archiv : European Journal of Physiology. 419: 662-4. PMID 1724077 DOI: 10.1007/BF00370312  1
1991 DiFrancesco D, Tortora P. Direct activation of cardiac pacemaker channels by intracellular cyclic AMP. Nature. 351: 145-7. PMID 1709448 DOI: 10.1038/351145a0  1
1990 Chang F, Gao J, Tromba C, Cohen I, DiFrancesco D. Acetylcholine reverses effects of beta-agonists on pacemaker current in canine cardiac Purkinje fibers but has no direct action. A difference between primary and secondary pacemakers. Circulation Research. 66: 633-6. PMID 1968362  1
1990 Porciatti F, DiFrancesco D. High Na permeability of L-type Ca channels in isolated rabbit SA node cells Journal of Physiology. 426: 18P.  1
1989 Cohen IS, DiFrancesco D, Mulrine NK, Pennefather P. Internal and external K+ help gate the inward rectifier. Biophysical Journal. 55: 197-202. PMID 2930821 DOI: 10.1016/S0006-3495(89)82792-4  1
1989 DiFrancesco D, Ducouret P, Robinson RB. Muscarinic modulation of cardiac rate at low acetylcholine concentrations. Science (New York, N.Y.). 243: 669-71. PMID 2916119  1
1989 Mazzanti M, DiFrancesco D. Intracellular Ca modulates K-inward rectification in cardiac myocytes. PflüGers Archiv : European Journal of Physiology. 413: 322-4. PMID 2717377 DOI: 10.1007/BF00581824  1
1988 DiFrancesco D, Tromba C. Inhibition of the hyperpolarization-activated current (if) induced by acetylcholine in rabbit sino-atrial node myocytes. The Journal of Physiology. 405: 477-91. PMID 3255798  1
1988 DiFrancesco D, Tromba C. Muscarinic control of the hyperpolarization-activated current (if) in rabbit sino-atrial node myocytes. The Journal of Physiology. 405: 493-510. PMID 2475609  1
1987 DiFrancesco D, Tromba C. Acetylcholine inhibits activation of the cardiac hyperpolarizing-activated current, if. PflüGers Archiv : European Journal of Physiology. 410: 139-42. PMID 2825112 DOI: 10.1007/BF00581906  1
1987 DiFrancesco D. The pacemaker current in the sinus node. European Heart Journal. 8: 19-23. PMID 2454189  1
1986 DiFrancesco D, Ferroni A, Mazzanti M, Tromba C. Properties of the hyperpolarizing-activated current (if) in cells isolated from the rabbit sino-atrial node. The Journal of Physiology. 377: 61-88. PMID 2432247 DOI: 10.1113/jphysiol.1986.sp016177  1
1986 DiFrancesco D. Characterization of single pacemaker channels in cardiac sino-atrial node cells. Nature. 324: 470-3. PMID 2431323 DOI: 10.1038/324470a0  1
1985 DiFrancesco D, Ferroni A, Visentin S, Zaza A. Cadmium-induced blockade of the cardiac fast Na channels in calf Purkinje fibres. Proceedings of the Royal Society of London. Series B, Biological Sciences. 223: 475-84. PMID 2580310  1
1985 DiFrancesco D, Noble D. A model of cardiac electrical activity incorporating ionic pumps and concentration changes. Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences. 307: 353-98. PMID 2578676  1
1985 DiFrancesco D. The cardiac hyperpolarizing-activated current, if. Origins and developments. Progress in Biophysics and Molecular Biology. 46: 163-83. PMID 2418458 DOI: 10.1016/0079-6107(85)90008-2  1
1984 DiFrancesco D. Properties of the cardiac pacemaker (if) current. Bollettino Della Società Italiana Di Biologia Sperimentale. 60: 29-33. PMID 6466486  1
1984 DiFrancesco D. Characterization of the pace-maker current kinetics in calf Purkinje fibres. The Journal of Physiology. 348: 341-67. PMID 6325672 DOI: 10.1113/jphysiol.1984.sp015114  1
1984 DiFrancesco D, Ferroni A, Visentin S. Barium-induced blockade of the inward rectifier in calf Purkinje fibres. PflüGers Archiv : European Journal of Physiology. 402: 446-53. PMID 6097875 DOI: 10.1007/BF00583946  1
1983 DiFrancesco D, Ferroni A. Delayed activation of the cardiac pacemaker current and its dependence on conditioning pre-hyperpolarizations. PflüGers Archiv : European Journal of Physiology. 396: 265-7. PMID 6302637 DOI: 10.1007/BF00587866  1
1982 DiFrancesco D. Block and activation of the pace-maker channel in calf purkinje fibres: effects of potassium, caesium and rubidium. The Journal of Physiology. 329: 485-507. PMID 6292407  1
1981 DiFrancesco D. A study of the ionic nature of the pace-maker current in calf Purkinje fibres. The Journal of Physiology. 314: 377-93. PMID 6273534  1
1981 DiFrancesco D. A new interpretation of the pace-maker current in calf Purkinje fibres. The Journal of Physiology. 314: 359-76. PMID 6273533  1
1981 Brown H, DiFrancesco D, Kimura J, Noble S. Caesium: A useful tool for investigating sino-atrial (S-A) node pace-making Journal of Physiology. 54P.  1
1980 DiFrancesco D, Noble D. The time course of potassium current following potassium accumulation in frog atrium: analytical solutions using a linear approximation. The Journal of Physiology. 306: 151-73. PMID 7463358  1
1980 Brown H, DiFrancesco D, Noble D, Noble S. The contribution of potassium accumulation to outward currents in frog atrium. The Journal of Physiology. 306: 127-49. PMID 7463357  1
1980 Brown H, Difrancesco D. Voltage-clamp investigations of membrane currents underlying pace-maker activity in rabbit sino-atrial node. The Journal of Physiology. 308: 331-51. PMID 7230019  1
1980 DiFrancesco D, Ojeda C. Properties of the current if in the sino-atrial node of the rabbit compared with those of the current iK, in Purkinje fibres. The Journal of Physiology. 308: 353-67. PMID 6262501  1
1980 DiFrancesco D, Noma A, Trautwein W. Separation of current induced by potassium accumulation from acetylcholine-induced relaxation current in the rabbit S-A node. PflüGers Archiv : European Journal of Physiology. 387: 83-90. PMID 6253876 DOI: 10.1007/BF00584257  1
1979 DiFrancesco D, Noma A, Trautwein W. Kinetics and magnitude of the time-dependent potassium current in the rabbit sinoatrial node: effect of external potassium. PflüGers Archiv : European Journal of Physiology. 381: 271-9. PMID 574637 DOI: 10.1007/BF00583259  1
1979 DiFrancesco D, Noble D. The influence of voltage non-uniformity on the determination of Erev for iK2. The Journal of Physiology. 297: 158-62. PMID 536908  1
1979 DiFrancesco D, Ohba M, Ojeda C. Measurement and significance of the reversal potential for the pace-maker current (iK2) in sheep Purkinje fibres. The Journal of Physiology. 297: 135-62. PMID 536907  1
1979 DiFrancesco D, Noble D. On the time course of extracellular ion concentration changes in frog atrium [proceedings]. The Journal of Physiology. 296: 80P. PMID 529149  1
1979 Brown HF, DiFrancesco D, Noble SJ. Adrenaline action on rabbit sino-atrial node Journal of Physiology. 31P-32P. PMID 469766  1
1979 DiFrancesco D, McNaughton PA. The effects of calcium on outward membrane currents in the cardiac Purkinje fibre. The Journal of Physiology. 289: 347-73. PMID 458668 DOI: 10.1113/jphysiol.1979.sp012741  1
1979 Brown HF, DiFrancesco D, Noble SJ. How does adrenaline accelerate the heart? Nature. 280: 235-6. PMID 450140 DOI: 10.1038/280235a0  1
1979 Brown H, Difrancesco D, Noble S. Cardiac pacemaker oscillation and its modulation by autonomic transmitters. The Journal of Experimental Biology. 81: 175-204. PMID 315983  1
1978 DiFrancesco D, Eisner DA, Lederer WJ. Low-potassium inotropy in cardiac muscle [proceedings]. The Journal of Physiology. 284: 138P-139P. PMID 731484  1
1978 DiFrancesco D, Ohba M. Dependence of the apparent reversal potential for the pace-maker current iK2 on its degree of activation in cardiac Purkinje fibres [proceedings]. The Journal of Physiology. 280: 73P-74P. PMID 690937  1
1978 Noma A, DiFrancesco D, Trautwein W. Dose-response curve for acetylcholine (ACh) and carbamylcholine (CCh) in the rabbit SA-node Pflugers Archiv European Journal of Physiology. 377: R4.  1
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