Vijay G. Sankaran, Ph.D. - Publications

Affiliations: 
2009 Harvard University, Cambridge, MA, United States 
Area:
Genetics

58 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2019 Ulirsch JC, Lareau CA, Bao EL, Ludwig LS, Guo MH, Benner C, Satpathy AT, Kartha VK, Salem RM, Hirschhorn JN, Finucane HK, Aryee MJ, Buenrostro JD, Sankaran VG. Interrogation of human hematopoiesis at single-cell and single-variant resolution. Nature Genetics. PMID 30858613 DOI: 10.1038/s41588-019-0362-6  0.32
2018 Raffield LM, Ulirsch JC, Naik RP, Lessard S, Handsaker RE, Jain D, Kang HM, Pankratz N, Auer PL, Bao EL, Smith JD, Lange LA, Lange EM, Li Y, Thornton TA, ... ... Sankaran VG, et al. Common α-globin variants modify hematologic and other clinical phenotypes in sickle cell trait and disease. Plos Genetics. 14: e1007293. PMID 29590102 DOI: 10.1371/journal.pgen.1007293  0.32
2016 Guo MH, Nandakumar SK, Ulirsch JC, Zekavat SM, Buenrostro JD, Natarajan P, Salem RM, Chiarle R, Mitt M, Kals M, Pärn K, Fischer K, Milani L, Mägi R, Palta P, ... ... Sankaran VG, et al. Comprehensive population-based genome sequencing provides insight into hematopoietic regulatory mechanisms. Proceedings of the National Academy of Sciences of the United States of America. PMID 28031487 DOI: 10.1073/pnas.1619052114  0.32
2016 Narla A, Yuan D, Kazerounian S, LaVasseur C, Ulirsch JC, Narla J, Glader B, Sankaran VG, Gazda H. A novel pathogenic mutation in RPL11 identified in a patient diagnosed with diamond Blackfan anemia as a young adult. Blood Cells, Molecules & Diseases. 61: 46-7. PMID 27667165 DOI: 10.1016/j.bcmd.2016.08.001  0.96
2016 Polfus LM, Khajuria RK, Schick UM, Pankratz N, Pazoki R, Brody JA, Chen MH, Auer PL, Floyd JS, Huang J, Lange L, van Rooij FJ, Gibbs RA, Metcalf G, Muzny D, ... ... Sankaran VG, et al. Whole-Exome Sequencing Identifies Loci Associated with Blood Cell Traits and Reveals a Role for Alternative GFI1B Splice Variants in Human Hematopoiesis. American Journal of Human Genetics. 99: 785. PMID 27588453 DOI: 10.1016/j.ajhg.2016.08.002  0.32
2016 Fukuda Y, Cheong PL, Lynch J, Brighton C, Frase S, Kargas V, Rampersaud E, Wang Y, Sankaran VG, Yu B, Ney PA, Weiss MJ, Vogel P, Bond PJ, Ford RC, et al. The severity of hereditary porphyria is modulated by the porphyrin exporter and Lan antigen ABCB6. Nature Communications. 7: 12353. PMID 27507172 DOI: 10.1038/ncomms12353  0.96
2016 Polfus LM, Khajuria RK, Schick UM, Pankratz N, Pazoki R, Brody JA, Chen MH, Auer PL, Floyd JS, Huang J, Lange L, van Rooij FJ, Gibbs RA, Metcalf G, Muzny D, ... ... Sankaran VG, et al. Whole-Exome Sequencing Identifies Loci Associated with Blood Cell Traits and Reveals a Role for Alternative GFI1B Splice Variants in Human Hematopoiesis. American Journal of Human Genetics. 99: 481-488. PMID 27486782 DOI: 10.1016/j.ajhg.2016.06.016  0.32
2016 Liddicoat BJ, Hartner JC, Piskol R, Ramaswami G, Chalk AM, Kingsley PD, Sankaran VG, Wall M, Purton LE, Seeburg PH, Palis J, Orkin SH, Lu J, Li JB, Walkley CR. Adenosine-to-insoine RNA editing by ADAR1 is essential for normal murine erythropoiesis. Experimental Hematology. PMID 27373493 DOI: 10.1016/j.exphem.2016.06.250  0.96
2016 Kim AR, Sankaran VG. Development of autologous blood cell therapies. Experimental Hematology. PMID 27345108 DOI: 10.1016/j.exphem.2016.06.005  0.96
2016 Capellera-Garcia S, Pulecio J, Dhulipala K, Siva K, Rayon-Estrada V, Singbrant S, Sommarin MN, Walkley CR, Soneji S, Karlsson G, Raya Á, Sankaran VG, Flygare J. Defining the Minimal Factors Required for Erythropoiesis through Direct Lineage Conversion. Cell Reports. PMID 27264182 DOI: 10.1016/j.celrep.2016.05.027  0.96
2016 Ulirsch JC, Nandakumar SK, Wang L, Giani FC, Zhang X, Rogov P, Melnikov A, McDonel P, Do R, Mikkelsen TS, Sankaran VG. Systematic Functional Dissection of Common Genetic Variation Affecting Red Blood Cell Traits. Cell. 165: 1530-1545. PMID 27259154 DOI: 10.1016/j.cell.2016.04.048  0.96
2016 Basak A, Sankaran VG. Regulation of the fetal hemoglobin silencing factor BCL11A. Annals of the New York Academy of Sciences. PMID 26963603 DOI: 10.1111/nyas.13024  0.96
2016 Nandakumar SK, Ulirsch JC, Sankaran VG. Advances in understanding erythropoiesis: evolving perspectives. British Journal of Haematology. PMID 26846448 DOI: 10.1111/bjh.13938  0.96
2015 Sabath DE, Bender MA, Sankaran VG, Vamos E, Kentsis A, Yi HS, Greisman HA. Characterization of Deletions of the HBA and HBB Loci by Array Comparative Genomic Hybridization. The Journal of Molecular Diagnostics : Jmd. PMID 26612711 DOI: 10.1016/j.jmoldx.2015.07.011  0.96
2015 Giani FC, Fiorini C, Wakabayashi A, Ludwig LS, Salem RM, Jobaliya CD, Regan SN, Ulirsch JC, Liang G, Steinberg-Shemer O, Guo MH, Esko T, Tong W, Brugnara C, Hirschhorn JN, ... ... Sankaran VG, et al. Targeted Application of Human Genetic Variation Can Improve Red Blood Cell Production from Stem Cells. Cell Stem Cell. PMID 26607381 DOI: 10.1016/j.stem.2015.09.015  0.96
2015 Wakabayashi A, Sankaran VG. Society for Pediatric Research 2015 Young Investigator Award: Genetics of human hematopoiesis-What patients can teach us about blood cell production. Pediatric Research. PMID 26575596 DOI: 10.1038/pr.2015.245  0.96
2015 Noh JY, Gandre-Babbe S, Wang Y, Hayes V, Yao Y, Gadue P, Sullivan SK, Chou ST, Machlus KR, Italiano JE, Kyba M, Finkelstein D, Ulirsch JC, Sankaran VG, French DL, et al. Inducible Gata1 suppression expands megakaryocyte-erythroid progenitors from embryonic stem cells. The Journal of Clinical Investigation. 125: 2369-74. PMID 25961454 DOI: 10.1172/JCI77670  0.96
2015 Basak A, Hancarova M, Ulirsch JC, Balci TB, Trkova M, Pelisek M, Vlckova M, Muzikova K, Cermak J, Trka J, Dyment DA, Orkin SH, Daly MJ, Sedlacek Z, Sankaran VG. BCL11A deletions result in fetal hemoglobin persistence and neurodevelopmental alterations. The Journal of Clinical Investigation. 125: 2363-8. PMID 25938782 DOI: 10.1172/JCI81163  0.96
2015 Sankaran VG, Ulirsch JC, Tchaikovskii V, Ludwig LS, Wakabayashi A, Kadirvel S, Lindsley RC, Bejar R, Shi J, Lovitch SB, Bishop DF, Steensma DP. X-linked macrocytic dyserythropoietic anemia in females with an ALAS2 mutation. The Journal of Clinical Investigation. 125: 1665-9. PMID 25705881 DOI: 10.1172/JCI78619  0.96
2015 Ludwig LS, Cho H, Wakabayashi A, Eng JC, Ulirsch JC, Fleming MD, Lodish HF, Sankaran VG. Genome-wide association study follow-up identifies cyclin A2 as a regulator of the transition through cytokinesis during terminal erythropoiesis. American Journal of Hematology. 90: 386-91. PMID 25615569 DOI: 10.1002/ajh.23952  0.96
2015 Basak A, Hancarova M, Ulirsch JC, Balci TB, Trkova M, Pelisek M, Vlckova M, Muzikova K, Cermak J, Trka J, Dyment DA, Orkin SH, Daly MJ, Sedlacek Z, Sankaran VG. BCL11A deletions result in fetal hemoglobin persistence and neurodevelopmental alterations Journal of Clinical Investigation. 125: 2363-2368. DOI: 10.1172/JCI81163  0.96
2015 Sankaran VG, Weiss MJ. Anemia: Progress in molecular mechanisms and therapies Nature Medicine. 21: 221-230. DOI: 10.1038/nm.3814  0.96
2014 Ulirsch JC, Lacy JN, An X, Mohandas N, Mikkelsen TS, Sankaran VG. Altered chromatin occupancy of master regulators underlies evolutionary divergence in the transcriptional landscape of erythroid differentiation. Plos Genetics. 10: e1004890. PMID 25521328 DOI: 10.1371/journal.pgen.1004890  0.96
2014 Ludwig LS, Gazda HT, Eng JC, Eichhorn SW, Thiru P, Ghazvinian R, George TI, Gotlib JR, Beggs AH, Sieff CA, Lodish HF, Lander ES, Sankaran VG. Altered translation of GATA1 in Diamond-Blackfan anemia. Nature Medicine. 20: 748-53. PMID 24952648 DOI: 10.1038/nm.3557  0.96
2014 Pishesha N, Thiru P, Shi J, Eng JC, Sankaran VG, Lodish HF. Transcriptional divergence and conservation of human and mouse erythropoiesis. Proceedings of the National Academy of Sciences of the United States of America. 111: 4103-8. PMID 24591581 DOI: 10.1073/pnas.1401598111  0.96
2013 Sankaran VG, Joshi M, Agrawal A, Schmitz-Abe K, Towne MC, Marinakis N, Markianos K, Berry GT, Agrawal PB. Rare complete loss of function provides insight into a pleiotropic genome-wide association study locus. Blood. 122: 3845-7. PMID 24288412 DOI: 10.1182/blood-2013-09-528315  0.96
2013 Sankaran VG, Gallagher PG. Applications of high-throughput DNA sequencing to benign hematology. Blood. 122: 3575-3582. PMID 24021670  0.96
2013 Sankaran VG, Agrawal PB. Stimulating erythropoiesis in neonates American Journal of Hematology. 88: 930-931. PMID 23963872 DOI: 10.1002/ajh.23573  0.96
2013 Sankaran VG, Orkin SH. Genome-wide association studies of hematologic phenotypes: A window into human hematopoiesis Current Opinion in Genetics and Development. 23: 339-344. PMID 23477921 DOI: 10.1016/j.gde.2013.02.006  0.96
2013 Musallam KM, Taher AT, Cappellini MD, Sankaran VG. Clinical experience with fetal hemoglobin induction therapy in patients with β-thalassemia. Blood. 121: 2199-2212; quiz 2372. PMID 23315167 DOI: 10.1182/blood-2012-10-408021  0.96
2013 Sankaran VG, Orkin SH. The switch from fetal to adult hemoglobin Cold Spring Harbor Perspectives in Medicine. 3. PMID 23209159 DOI: 10.1101/cshperspect.a011643  0.96
2012 Sankaran VG, Ludwig LS, Sicinska E, Xu J, Bauer DE, Eng JC, Patterson HC, Metcalf RA, Natkunam Y, Orkin SH, Sicinski P, Lander ES, Lodish HF. Cyclin D3 coordinates the cell cycle during differentiation to regulate erythrocyte size and number. Genes & Development. 26: 2075-87. PMID 22929040 DOI: 10.1101/gad.197020.112  0.96
2012 Sankaran VG, Ghazvinian R, Do R, Thiru P, Vergilio JA, Beggs AH, Sieff CA, Orkin SH, Nathan DG, Lander ES, Gazda HT. Exome sequencing identifies GATA1 mutations resulting in Diamond-Blackfan anemia. The Journal of Clinical Investigation. 122: 2439-43. PMID 22706301 DOI: 10.1172/JCI63597  0.96
2012 Zhang L, Sankaran VG, Lodish HF. MicroRNAs in erythroid and megakaryocytic differentiation and megakaryocyte-erythroid progenitor lineage commitment. Leukemia. 26: 2310-6. PMID 22617791 DOI: 10.1038/leu.2012.137  0.96
2012 Musallam KM, Sankaran VG, Cappellini MD, Duca L, Nathan DG, Taher AT. Fetal hemoglobin levels and morbidity in untransfused patients with β-thalassemia intermedia. Blood. 119: 364-7. PMID 22096240 DOI: 10.1182/blood-2011-09-382408  0.96
2012 Sankaran VG, Sapp MV. Persistence of fetal hemoglobin expression in an older child with trisomy 13 Journal of Pediatrics. 160: 352. PMID 21885064 DOI: 10.1016/j.jpeds.2011.07.036  0.96
2011 Sankaran VG. Targeted therapeutic strategies for fetal hemoglobin induction. Hematology / the Education Program of the American Society of Hematology. American Society of Hematology. Education Program. 2011: 459-465. PMID 22160074  0.96
2011 Xu J, Peng C, Sankaran VG, Shao Z, Esrick EB, Chong BG, Ippolito GC, Fujiwara Y, Ebert BL, Tucker PW, Orkin SH. Correction of sickle cell disease in adult mice by interference with fetal hemoglobin silencing. Science (New York, N.Y.). 334: 993-6. PMID 21998251 DOI: 10.1126/science.1211053  0.96
2011 Sankaran VG, Xu J, Byron R, Greisman HA, Fisher C, Weatherall DJ, Sabath DE, Groudine M, Orkin SH, Premawardhena A, Bender MA. A functional element necessary for fetal hemoglobin silencing. The New England Journal of Medicine. 365: 807-14. PMID 21879898 DOI: 10.1056/NEJMoa1103070  0.96
2011 Sankaran VG, Menne J, Heller R. Heterozygous disruption of human SOX6 is insufficient to impair erythropoiesis or silencing of fetal hemoglobin Blood. 117: 4396-4397. PMID 21511965 DOI: 10.1182/blood-2010-11-320887  0.96
2011 Singbrant S, Russell MR, Jovic T, Liddicoat B, Izon DJ, Purton LE, Sims NA, Martin TJ, Sankaran VG, Walkley CR. Erythropoietin couples erythropoiesis, B-lymphopoiesis, and bone homeostasis within the bone marrow microenvironment Blood. 117: 5631-5642. PMID 21421837 DOI: 10.1182/blood-2010-11-320564  0.96
2011 Sankaran VG, Menne TF, Šćepanović D, Vergilio JA, Ji P, Kim J, Thiru P, Orkin SH, Lander ES, Lodish HF. MicroRNA-15a and -16-1 act via MYB to elevate fetal hemoglobin expression in human trisomy 13. Proceedings of the National Academy of Sciences of the United States of America. 108: 1519-24. PMID 21205891 DOI: 10.1073/pnas.1018384108  0.96
2011 Wilber A, Hargrove PW, Kim YS, Riberdy JM, Sankaran VG, Papanikolaou E, Georgomanoli M, Anagnou NP, Orkin SH, Nienhuis AW, Persons DA. Therapeutic levels of fetal hemoglobin in erythroid progeny of β-thalassemic CD34+ cells after lentiviral vector-mediated gene transfer. Blood. 117: 2817-26. PMID 21156846 DOI: 10.1182/blood-2010-08-300723  0.96
2010 Sankaran VG, Nathan DG. Reversing the hemoglobin switch. The New England Journal of Medicine. 363: 2258-60. PMID 21121839 DOI: 10.1056/NEJMcibr1010767  0.96
2010 Sankaran VG, Nathan DG. Thalassemia: an overview of 50 years of clinical research. Hematology/Oncology Clinics of North America. 24: 1005-20. PMID 21075277 DOI: 10.1016/j.hoc.2010.08.009  0.96
2010 Galarneau G, Palmer CD, Sankaran VG, Orkin SH, Hirschhorn JN, Lettre G. Fine-mapping at three loci known to affect fetal hemoglobin levels explains additional genetic variation Nature Genetics. 42: 1049-1051. PMID 21057501 DOI: 10.1038/ng.707  0.96
2010 Sankaran VG, Lettre G, Orkin SH, Hirschhorn JN. Modifier genes in Mendelian disorders: the example of hemoglobin disorders. Annals of the New York Academy of Sciences. 1214: 47-56. PMID 21039591 DOI: 10.1111/j.1749-6632.2010.05821.x  0.96
2010 Sankaran VG, Xu J, Orkin SH. Transcriptional silencing of fetal hemoglobin by BCL11A. Annals of the New York Academy of Sciences. 1202: 64-8. PMID 20712774 DOI: 10.1111/j.1749-6632.2010.05574.x  0.96
2010 Sankaran VG. Hemoglobin disorders in the developing world: a perspective from Sri Lanka. American Journal of Hematology. 85: 732. PMID 20645427 DOI: 10.1002/ajh.21769  0.96
2010 Xu J, Sankaran VG, Ni M, Menne TF, Puram RV, Kim W, Orkin SH. Transcriptional silencing of {gamma}-globin by BCL11A involves long-range interactions and cooperation with SOX6. Genes & Development. 24: 783-98. PMID 20395365 DOI: 10.1101/gad.1897310  0.96
2010 Sankaran VG, Xu J, Orkin SH. Advances in the understanding of haemoglobin switching. British Journal of Haematology. 149: 181-94. PMID 20201948 DOI: 10.1111/j.1365-2141.2010.08105.x  0.96
2009 Sankaran VG, Xu J, Ragoczy T, Ippolito GC, Walkley CR, Maika SD, Fujiwara Y, Ito M, Groudine M, Bender MA, Tucker PW, Orkin SH. Developmental and species-divergent globin switching are driven by BCL11A. Nature. 460: 1093-7. PMID 19657335 DOI: 10.1038/nature08243  0.96
2008 Sankaran VG, Menne TF, Xu J, Akie TE, Lettre G, Van Handel B, Mikkola HK, Hirschhorn JN, Cantor AB, Orkin SH. Human fetal hemoglobin expression is regulated by the developmental stage-specific repressor BCL11A. Science (New York, N.Y.). 322: 1839-42. PMID 19056937 DOI: 10.1126/science.1165409  0.96
2008 Walkley CR, Sankaran VG, Orkin SH. Rb and hematopoiesis: stem cells to anemia. Cell Division. 3: 13. PMID 18775080 DOI: 10.1186/1747-1028-3-13  0.96
2008 Lettre G, Sankaran VG, Bezerra MA, Araújo AS, Uda M, Sanna S, Cao A, Schlessinger D, Costa FF, Hirschhorn JN, Orkin SH. DNA polymorphisms at the BCL11A, HBS1L-MYB, and beta-globin loci associate with fetal hemoglobin levels and pain crises in sickle cell disease. Proceedings of the National Academy of Sciences of the United States of America. 105: 11869-74. PMID 18667698 DOI: 10.1073/pnas.0804799105  0.96
2008 Walkley CR, Qudsi R, Sankaran VG, Perry JA, Gostissa M, Roth SI, Rodda SJ, Snay E, Dunning P, Fahey FH, Alt FW, McMahon AP, Orkin SH. Conditional mouse osteosarcoma, dependent on p53 loss and potentiated by loss of Rb, mimics the human disease. Genes & Development. 22: 1662-76. PMID 18559481 DOI: 10.1101/gad.1656808  0.96
2008 Sankaran VG, Orkin SH, Walkley CR. Rb intrinsically promotes erythropoiesis by coupling cell cycle exit with mitochondrial biogenesis. Genes & Development. 22: 463-75. PMID 18258751 DOI: 10.1101/gad.1627208  0.96
2008 Uda M, Galanello R, Sanna S, Lettre G, Sankaran VG, Chen W, Usala G, Busonero F, Maschio A, Albai G, Piras MG, Sestu N, Lai S, Dei M, Mulas A, et al. Genome-wide association study shows BCL11A associated with persistent fetal hemoglobin and amelioration of the phenotype of beta-thalassemia. Proceedings of the National Academy of Sciences of the United States of America. 105: 1620-5. PMID 18245381 DOI: 10.1073/pnas.0711566105  0.96
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