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Frank B. Gertler, Ph.D. - Publications

Koch Institute Massachusetts Institute of Technology, Cambridge, MA, United States 
growth cone dynamics, cortical migration

121 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2016 Balsamo M, Mondal C, Carmona G, McClain LM, Riquelme DN, Tadros J, Ma D, Vasile E, Condeelis JS, Lauffenburger DA, Gertler FB. The alternatively-included 11a sequence modifies the effects of Mena on actin cytoskeletal organization and cell behavior. Scientific Reports. 6: 35298. PMID 27748415 DOI: 10.1038/Srep35298  0.32
2016 Oudin MJ, Miller MA, Klazen JA, Kosciuk T, Lussiez A, Hughes SK, Tadros J, Bear JE, Lauffenburger DA, Gertler FB. MenaINV mediates synergistic crosstalk between signaling pathways driving chemotaxis and haptotaxis. Molecular Biology of the Cell. PMID 27559126 DOI: 10.1091/Mbc.E16-04-0212  0.8
2016 McConnell RE, Edward van Veen J, Vidaki M, Kwiatkowski AV, Meyer AS, Gertler FB. A requirement for filopodia extension toward Slit during Robo-mediated axon repulsion. The Journal of Cell Biology. PMID 27091449 DOI: 10.1083/Jcb.201509062  0.92
2016 Carmona G, Perera U, Gillett C, Naba A, Law AL, Sharma VP, Wang J, Wyckoff J, Balsamo M, Mosis F, De Piano M, Monypenny J, Woodman N, McConnell RE, Mouneimne G, ... ... Gertler FB, et al. Lamellipodin promotes invasive 3D cancer cell migration via regulated interactions with Ena/VASP and SCAR/WAVE. Oncogene. PMID 26996666 DOI: 10.1038/Onc.2016.47  0.4
2016 Oudin MJ, Jonas O, Kosciuk T, Broye LC, Guido BC, Wyckoff J, Riquelme D, Lamar JM, Asokan SB, Whittaker C, Ma D, Langer R, Cima MJ, Wisinski KB, Hynes RO, ... ... Gertler FB, et al. Tumor cell-driven extracellular matrix remodeling enables haptotaxis during metastatic progression. Cancer Discovery. PMID 26811325 DOI: 10.1158/2159-8290.Cd-15-1183  0.92
2015 Hughes SK, Oudin MJ, Tadros J, Neil J, Del Rosario A, Joughin BA, Ritsma L, Wyckoff J, Vasile E, Eddy R, Philippar U, Lussiez A, Condeelis JS, van Rheenen J, White F, ... ... Gertler FB, et al. PTP1B-dependent regulation of receptor tyrosine kinase signaling by the actin-binding protein Mena. Molecular Biology of the Cell. PMID 26337385 DOI: 10.1091/Mbc.E15-06-0442  0.92
2015 Riquelme DN, Meyer AS, Barzik M, Keating A, Gertler FB. Selectivity in subunit composition of Ena/VASP tetramers. Bioscience Reports. 35. PMID 26221026 DOI: 10.1042/Bsr20150149  0.92
2015 Kumari S, Depoil D, Martinelli R, Judokusumo E, Carmona G, Gertler FB, Kam LC, Carman CV, Burkhardt JK, Irvine DJ, Dustin ML. Actin foci facilitate activation of the phospholipase C-γ in primary T lymphocytes via the WASP pathway. Elife. 4. PMID 25758716 DOI: 10.7554/Elife.04953  0.92
2015 Forse CL, Agarwal S, Pinnaduwage D, Gertler F, Condeelis JS, Lin J, Xue X, Johung K, Mulligan AM, Rohan TE, Bull SB, Andrulis IL. Menacalc, a quantitative method of metastasis assessment, as a prognostic marker for axillary node-negative breast cancer Bmc Cancer. 15. DOI: 10.1186/s12885-015-1468-6  0.92
2014 Barzik M, McClain LM, Gupton SL, Gertler FB. Ena/VASP regulates mDia2-initiated filopodial length, dynamics, and function. Molecular Biology of the Cell. 25: 2604-19. PMID 24989797 DOI: 10.1091/Mbc.E14-02-0712  0.92
2013 Meyer AS, Miller MA, Gertler FB, Lauffenburger DA. The receptor AXL diversifies EGFR signaling and limits the response to EGFR-targeted inhibitors in triple-negative breast cancer cells. Science Signaling. 6: ra66. PMID 23921085 DOI: 10.1126/Scisignal.2004155  0.92
2013 Belmonte SL, Ram R, Mickelsen DM, Gertler FB, Blaxall BC. Cardiac overexpression of Mammalian enabled (Mena) exacerbates heart failure in mice. American Journal of Physiology. Heart and Circulatory Physiology. 305: H875-84. PMID 23832697 DOI: 10.1152/Ajpheart.00342.2013  0.92
2012 Mouneimne G, Hansen SD, Selfors LM, Petrak L, Hickey MM, Gallegos LL, Simpson KJ, Lim J, Gertler FB, Hartwig JH, Mullins RD, Brugge JS. Differential remodeling of actin cytoskeleton architecture by profilin isoforms leads to distinct effects on cell migration and invasion. Cancer Cell. 22: 615-30. PMID 23153535 DOI: 10.1016/J.Ccr.2012.09.027  0.92
2012 Gupton SL, Riquelme D, Hughes-Alford SK, Tadros J, Rudina SS, Hynes RO, Lauffenburger D, Gertler FB. Mena binds α5 integrin directly and modulates α5β1 function. The Journal of Cell Biology. 198: 657-76. PMID 22908313 DOI: 10.1083/Jcb.201202079  0.92
2012 Meyer AS, Hughes-Alford SK, Kay JE, Castillo A, Wells A, Gertler FB, Lauffenburger DA. 2D protrusion but not motility predicts growth factor-induced cancer cell migration in 3D collagen. The Journal of Cell Biology. 197: 721-9. PMID 22665521 DOI: 10.1083/Jcb.201201003  0.92
2012 Okada H, Uezu A, Soderblom EJ, Moseley MA, Gertler FB, Soderling SH. Peptide array X-linking (PAX): a new peptide-protein identification approach. Plos One. 7: e37035. PMID 22606326 DOI: 10.1371/Journal.Pone.0037035  0.92
2011 Ma CH, Omura T, Cobos EJ, Latrémolière A, Ghasemlou N, Brenner GJ, van Veen E, Barrett L, Sawada T, Gao F, Coppola G, Gertler F, Costigan M, Geschwind D, Woolf CJ. Accelerating axonal growth promotes motor recovery after peripheral nerve injury in mice. The Journal of Clinical Investigation. 121: 4332-47. PMID 21965333 DOI: 10.1172/Jci58675  0.92
2011 Shapiro IM, Cheng AW, Flytzanis NC, Balsamo M, Condeelis JS, Oktay MH, Burge CB, Gertler FB. An EMT-driven alternative splicing program occurs in human breast cancer and modulates cellular phenotype. Plos Genetics. 7: e1002218. PMID 21876675 DOI: 10.1371/Journal.Pgen.1002218  0.92
2011 Kim HD, Meyer AS, Wagner JP, Alford SK, Wells A, Gertler FB, Lauffenburger DA. Signaling network state predicts twist-mediated effects on breast cell migration across diverse growth factor contexts. Molecular & Cellular Proteomics : McP. 10: M111.008433. PMID 21832255 DOI: 10.1074/Mcp.M111.008433  0.92
2011 Pinheiro EM, Xie Z, Norovich AL, Vidaki M, Tsai LH, Gertler FB. Lpd depletion reveals that SRF specifies radial versus tangential migration of pyramidal neurons. Nature Cell Biology. 13: 989-95. PMID 21785421 DOI: 10.1038/Ncb2292  0.92
2011 Roussos ET, Balsamo M, Alford SK, Wyckoff JB, Gligorijevic B, Wang Y, Pozzuto M, Stobezki R, Goswami S, Segall JE, Lauffenburger DA, Bresnick AR, Gertler FB, Condeelis JS. Mena invasive (MenaINV) promotes multicellular streaming motility and transendothelial migration in a mouse model of breast cancer. Journal of Cell Science. 124: 2120-31. PMID 21670198 DOI: 10.1242/Jcs.086231  0.92
2011 Roussos ET, Goswami S, Balsamo M, Wang Y, Stobezki R, Adler E, Robinson BD, Jones JG, Gertler FB, Condeelis JS, Oktay MH. Mena invasive (Mena(INV)) and Mena11a isoforms play distinct roles in breast cancer cell cohesion and association with TMEM. Clinical & Experimental Metastasis. 28: 515-27. PMID 21484349 DOI: 10.1007/S10585-011-9388-6  0.92
2011 Aguilar F, Belmonte SL, Ram R, Noujaim SF, Dunaevsky O, Protack TL, Jalife J, Todd Massey H, Gertler FB, Blaxall BC. Mammalian enabled (Mena) is a critical regulator of cardiac function. American Journal of Physiology. Heart and Circulatory Physiology. 300: H1841-52. PMID 21335464 DOI: 10.1152/Ajpheart.01127.2010  0.92
2011 Kothapalli CR, van Veen E, de Valence S, Chung S, Zervantonakis IK, Gertler FB, Kamm RD. A high-throughput microfluidic assay to study neurite response to growth factor gradients. Lab On a Chip. 11: 497-507. PMID 21107471 DOI: 10.1039/C0Lc00240B  0.92
2011 Dent EW, Gupton SL, Gertler FB. The growth cone cytoskeleton in axon outgrowth and guidance. Cold Spring Harbor Perspectives in Biology. 3. PMID 21106647 DOI: 10.1101/Cshperspect.A001800  0.92
2011 Gertler F, Condeelis J. Metastasis: Tumor cells becoming MENAcing Trends in Cell Biology. 21: 81-90. PMID 21071226 DOI: 10.1016/J.Tcb.2010.10.001  0.92
2010 Bae YH, Ding Z, Das T, Wells A, Gertler F, Roy P. Profilin1 regulates PI(3,4)P2 and lamellipodin accumulation at the leading edge thus influencing motility of MDA-MB-231 cells. Proceedings of the National Academy of Sciences of the United States of America. 107: 21547-52. PMID 21115820 DOI: 10.1073/Pnas.1002309107  0.92
2010 Roussos ET, Wang Y, Wyckoff JB, Sellers RS, Wang W, Li J, Pollard JW, Gertler FB, Condeelis JS. Mena deficiency delays tumor progression and decreases metastasis in polyoma middle-T transgenic mouse mammary tumors. Breast Cancer Research : Bcr. 12: R101. PMID 21108830 DOI: 10.1186/Bcr2784  0.92
2010 Nakatsu F, Perera RM, Lucast L, Zoncu R, Domin J, Gertler FB, Toomre D, De Camilli P. The inositol 5-phosphatase SHIP2 regulates endocytic clathrin-coated pit dynamics. The Journal of Cell Biology. 190: 307-15. PMID 20679431 DOI: 10.1083/Jcb.201005018  0.92
2010 Hao JC, Adler CE, Mebane L, Gertler FB, Bargmann CI, Tessier-Lavigne M. The tripartite motif protein MADD-2 functions with the receptor UNC-40 (DCC) in Netrin-mediated axon attraction and branching. Developmental Cell. 18: 950-60. PMID 20627077 DOI: 10.1016/J.Devcel.2010.02.019  0.92
2010 Gupton SL, Gertler FB. Integrin signaling switches the cytoskeletal and exocytic machinery that drives neuritogenesis. Developmental Cell. 18: 725-36. PMID 20493807 DOI: 10.1016/J.Devcel.2010.02.017  0.92
2010 Worth DC, Hodivala-Dilke K, Robinson SD, King SJ, Morton PE, Gertler FB, Humphries MJ, Parsons M. Alpha v beta3 integrin spatially regulates VASP and RIAM to control adhesion dynamics and migration. The Journal of Cell Biology. 189: 369-83. PMID 20404115 DOI: 10.1083/Jcb.200912014  0.92
2009 Benz PM, Blume C, Seifert S, Wilhelm S, Waschke J, Schuh K, Gertler F, Münzel T, Renné T. Differential VASP phosphorylation controls remodeling of the actin cytoskeleton Journal of Cell Science. 122: 3954-3965. PMID 19825941 DOI: 10.1242/Jcs.044537  0.92
2009 Meacham CE, Ho EE, Dubrovsky E, Gertler FB, Hemann MT. In vivo RNAi screening identifies regulators of actin dynamics as key determinants of lymphoma progression. Nature Genetics. 41: 1133-7. PMID 19783987 DOI: 10.1038/Ng.451  0.92
2009 Sartoretto JL, Jin BY, Bauer M, Gertler FB, Liao R, Michel T. Regulation of VASP phosphorylation in cardiac myocytes: differential regulation by cyclic nucleotides and modulation of protein expression in diabetic and hypertrophic heart. American Journal of Physiology. Heart and Circulatory Physiology. 297: H1697-710. PMID 19734360 DOI: 10.1152/Ajpheart.00595.2009  0.92
2009 Menna E, Disanza A, Cagnoli C, Schenk U, Gelsomino G, Frittoli E, Hertzog M, Offenhauser N, Sawallisch C, Kreienkamp HJ, Gertler FB, Di Fiore PP, Scita G, Matteoli M. Eps8 regulates axonal filopodia in hippocampal neurons in response to brain-derived neurotrophic factor (BDNF). Plos Biology. 7: e1000138. PMID 19564905 DOI: 10.1371/Journal.Pbio.1000138  0.92
2009 Bear JE, Gertler FB. Ena/VASP: towards resolving a pointed controversy at the barbed end. Journal of Cell Science. 122: 1947-53. PMID 19494122 DOI: 10.1242/Jcs.038125  0.92
2009 Neel NF, Barzik M, Raman D, Sobolik-Delmaire T, Sai J, Ham AJ, Mernaugh RL, Gertler FB, Richmond A. VASP is a CXCR2-interacting protein that regulates CXCR2-mediated polarization and chemotaxis. Journal of Cell Science. 122: 1882-94. PMID 19435808 DOI: 10.1242/Jcs.039057  0.92
2009 Kwiatkowski AV, Garner CC, Nelson WJ, Gertler FB. Cell autonomous defects in cortical development revealed by two-color chimera analysis. Molecular and Cellular Neurosciences. 41: 44-50. PMID 19386231 DOI: 10.1016/J.Mcn.2009.01.008  0.92
2009 Robinson BD, Sica GL, Liu YF, Rohan TE, Gertler FB, Condeelis JS, Jones JG. Tumor microenvironment of metastasis in human breast carcinoma: a potential prognostic marker linked to hematogenous dissemination. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 15: 2433-41. PMID 19318480 DOI: 10.1158/1078-0432.Ccr-08-2179  0.92
2009 Bae YH, Ding Z, Zou L, Wells A, Gertler F, Roy P. Loss of profilin-1 expression enhances breast cancer cell motility by Ena/VASP proteins. Journal of Cellular Physiology. 219: 354-64. PMID 19115233 DOI: 10.1002/Jcp.21677  0.92
2009 Janssens K, De Kimpe L, Balsamo M, Vandoninck S, Vandenheede JR, Gertler F, Van Lint J. Characterization of EVL-I as a protein kinase D substrate Cellular Signalling. 21: 282-292. PMID 19000756 DOI: 10.1016/J.Cellsig.2008.10.012  0.92
2009 Goswami S, Philippar U, Sun D, Patsialou A, Avraham J, Wang W, Di Modugno F, Nistico P, Gertler FB, Condeelis JS. Identification of invasion specific splice variants of the cytoskeletal protein Mena present in mammary tumor cells during invasion in vivo. Clinical & Experimental Metastasis. 26: 153-9. PMID 18985426 DOI: 10.1007/S10585-008-9225-8  0.92
2008 Philippar U, Roussos ET, Oser M, Yamaguchi H, Kim HD, Giampieri S, Wang Y, Goswami S, Wyckoff JB, Lauffenburger DA, Sahai E, Condeelis JS, Gertler FB. A Mena invasion isoform potentiates EGF-induced carcinoma cell invasion and metastasis. Developmental Cell. 15: 813-28. PMID 19081071 DOI: 10.1016/J.Devcel.2008.09.003  0.92
2008 Pino MS, Balsamo M, Di Modugno F, Mottolese M, Alessio M, Melucci E, Milella M, McConkey DJ, Philippar U, Gertler FB, Natali PG, Nisticò P. Human Mena+11a isoform serves as a marker of epithelial phenotype and sensitivity to epidermal growth factor receptor inhibition in human pancreatic cancer cell lines. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 14: 4943-50. PMID 18676769 DOI: 10.1158/1078-0432.Ccr-08-0436  0.92
2008 Kim HD, Guo TW, Wu AP, Wells A, Gertler FB, Lauffenburger DA. Epidermal growth factor-induced enhancement of glioblastoma cell migration in 3D arises from an intrinsic increase in speed but an extrinsic matrix- and proteolysis-dependent increase in persistence. Molecular Biology of the Cell. 19: 4249-59. PMID 18632979 DOI: 10.1091/Mbc.E08-05-0501  0.92
2008 Drees F, Gertler FB. Ena/VASP: proteins at the tip of the nervous system. Current Opinion in Neurobiology. 18: 53-9. PMID 18508258 DOI: 10.1016/J.Conb.2008.05.007  0.92
2007 Dent EW, Kwiatkowski AV, Mebane LM, Philippar U, Barzik M, Rubinson DA, Gupton S, Van Veen JE, Furman C, Zhang J, Alberts AS, Mori S, Gertler FB. Filopodia are required for cortical neurite initiation. Nature Cell Biology. 9: 1347-59. PMID 18026093 DOI: 10.1038/Ncb1654  0.92
2007 Furman C, Sieminski AL, Kwiatkowski AV, Rubinson DA, Vasile E, Bronson RT, Fässler R, Gertler FB. Ena/VASP is required for endothelial barrier function in vivo. The Journal of Cell Biology. 179: 761-75. PMID 17998398 DOI: 10.1083/Jcb.200705002  0.92
2007 Kwiatkowski AV, Rubinson DA, Dent EW, Edward van Veen J, Leslie JD, Zhang J, Mebane LM, Philippar U, Pinheiro EM, Burds AA, Bronson RT, Mori S, Fässler R, Gertler FB. Ena/VASP Is Required for neuritogenesis in the developing cortex. Neuron. 56: 441-55. PMID 17988629 DOI: 10.1016/J.Neuron.2007.09.008  0.92
2007 Lacayo CI, Pincus Z, VanDuijn MM, Wilson CA, Fletcher DA, Gertler FB, Mogilner A, Theriot JA. Emergence of large-scale cell morphology and movement from local actin filament growth dynamics. Plos Biology. 5: e233. PMID 17760506 DOI: 10.1371/Journal.Pbio.0050233  0.92
2007 Gupton SL, Gertler FB. Filopodia: the fingers that do the walking. Science's Stke : Signal Transduction Knowledge Environment. 2007: re5. PMID 17712139 DOI: 10.1126/Stke.4002007Re5  0.92
2007 Dwivedy A, Gertler FB, Miller J, Holt CE, Lebrand C. Ena/VASP function in retinal axons is required for terminal arborization but not pathway navigation. Development (Cambridge, England). 134: 2137-46. PMID 17507414 DOI: 10.1242/Dev.002345  0.92
2007 Gates J, Mahaffey JP, Rogers SL, Emerson M, Rogers EM, Sottile SL, Van Vactor D, Gertler FB, Peifer M. Enabled plays key roles in embryonic epithelial morphogenesis in Drosophila. Development (Cambridge, England). 134: 2027-39. PMID 17507404 DOI: 10.1242/Dev.02849  0.92
2007 Applewhite DA, Barzik M, Kojima S, Svitkina TM, Gertler FB, Borisy GG. Ena/VASP proteins have an anti-capping independent function in filopodia formation. Molecular Biology of the Cell. 18: 2579-91. PMID 17475772 DOI: 10.1091/Mbc.E06-11-0990  0.92
2007 Evans IR, Renne T, Gertler FB, Nobes CD. Ena/VASP proteins mediate repulsion from ephrin ligands. Journal of Cell Science. 120: 289-98. PMID 17179204 DOI: 10.1242/Jcs.03333  0.92
2007 Rubinson DA, Dillon CP, Kwiatkowski AV, Sievers C, Yang L, Kopinja J, Zhang M, McManus MT, Gertler FB, Scott ML, Van Parijs L. Erratum: Corrigendum: A lentivirus-based system to functionally silence genes in primary mammalian cells, stem cells and transgenic mice by RNA interference Nature Genetics. 39: 803-803. DOI: 10.1038/Ng0607-803  0.36
2006 Rostaing P, Real E, Siksou L, Lechaire JP, Boudier T, Boeckers TM, Gertler F, Gundelfinger ED, Triller A, Marty S. Analysis of synaptic ultrastructure without fixative using high-pressure freezing and tomography. The European Journal of Neuroscience. 24: 3463-74. PMID 17229095 DOI: 10.1111/J.1460-9568.2006.05234.X  0.92
2006 Pinheiro EM, Gertler FB. Nervous Rac: DOCK7 regulation of axon formation. Neuron. 51: 674-6. PMID 16982410 DOI: 10.1016/J.Neuron.2006.08.020  0.92
2006 Kovacs EM, Makar RS, Gertler FB. Tuba stimulates intracellular N-WASP-dependent actin assembly. Journal of Cell Science. 119: 2715-26. PMID 16757518 DOI: 10.1242/Jcs.03005  0.92
2006 Chang C, Adler CE, Krause M, Clark SG, Gertler FB, Tessier-Lavigne M, Bargmann CI. MIG-10/lamellipodin and AGE-1/PI3K promote axon guidance and outgrowth in response to slit and netrin. Current Biology : Cb. 16: 854-62. PMID 16618541 DOI: 10.1016/J.Cub.2006.03.083  0.4
2006 Scott JA, Shewan AM, den Elzen NR, Loureiro JJ, Gertler FB, Yap AS. Ena/VASP proteins can regulate distinct modes of actin organization at cadherin-adhesive contacts. Molecular Biology of the Cell. 17: 1085-95. PMID 16371509 DOI: 10.1091/Mbc.E05-07-0644  0.92
2005 Cestra G, Kwiatkowski A, Salazar M, Gertler F, De Camilli P. Tuba, a GEF for CDC42, links dynamin to actin regulatory proteins. Methods in Enzymology. 404: 537-45. PMID 16413298 DOI: 10.1016/S0076-6879(05)04047-4  0.92
2005 Barzik M, Kotova TI, Higgs HN, Hazelwood L, Hanein D, Gertler FB, Schafer DA. Ena/VASP proteins enhance actin polymerization in the presence of barbed end capping proteins. The Journal of Biological Chemistry. 280: 28653-62. PMID 15939738 DOI: 10.1074/Jbc.M503957200  0.92
2005 Sahai E, Wyckoff J, Philippar U, Segall JE, Gertler F, Condeelis J. Simultaneous imaging of GFP, CFP and collagen in tumors in vivo using multiphoton microscopy Bmc Biotechnology. 5. PMID 15910685 DOI: 10.1186/1472-6750-5-14  0.92
2005 Bierne H, Miki H, Innocenti M, Scita G, Gertler FB, Takenawa T, Cossart P. WASP-related proteins, Abi1 and Ena/VASP are required for Listeria invasion induced by the Met receptor. Journal of Cell Science. 118: 1537-47. PMID 15769844 DOI: 10.1242/Jcs.02285  0.92
2004 Philippar U, Schratt G, Dieterich C, Müller JM, Galgóczy P, Engel FB, Keating MT, Gertler F, Schüle R, Vingron M, Nordheim A. The SRF target gene Fhl2 antagonizes RhoA/MAL-dependent activation of SRF. Molecular Cell. 16: 867-80. PMID 15610731 DOI: 10.1016/J.Molcel.2004.11.039  0.92
2004 Lafuente EM, van Puijenbroek AA, Krause M, Carman CV, Freeman GJ, Berezovskaya A, Constantine E, Springer TA, Gertler FB, Boussiotis VA. RIAM, an Ena/VASP and Profilin ligand, interacts with Rap1-GTP and mediates Rap1-induced adhesion. Developmental Cell. 7: 585-95. PMID 15469846 DOI: 10.1016/J.Devcel.2004.07.021  0.92
2004 Krause M, Leslie JD, Stewart M, Lafuente EM, Valderrama F, Jagannathan R, Strasser GA, Rubinson DA, Liu H, Way M, Yaffe MB, Boussiotis VA, Gertler FB. Lamellipodin, an Ena/VASP ligand, is implicated in the regulation of lamellipodial dynamics. Developmental Cell. 7: 571-83. PMID 15469845 DOI: 10.1016/J.Devcel.2004.07.024  0.92
2004 Menzies AS, Aszodi A, Williams SE, Pfeifer A, Wehman AM, Goh KL, Mason CA, Fassler R, Gertler FB. Mena and vasodilator-stimulated phosphoprotein are required for multiple actin-dependent processes that shape the vertebrate nervous system. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 24: 8029-38. PMID 15371503 DOI: 10.1523/Jneurosci.1057-04.2004  0.92
2004 Mejillano MR, Kojima S, Applewhite DA, Gertler FB, Svitkina TM, Borisy GG. Lamellipodial versus filopodial mode of the actin nanomachinery: pivotal role of the filament barbed end. Cell. 118: 363-73. PMID 15294161 DOI: 10.1016/J.Cell.2004.07.019  0.92
2004 Strasser GA, Rahim NA, VanderWaal KE, Gertler FB, Lanier LM. Arp2/3 is a negative regulator of growth cone translocation. Neuron. 43: 81-94. PMID 15233919 DOI: 10.1016/J.Neuron.2004.05.015  0.92
2004 Lebrand C, Dent EW, Strasser GA, Lanier LM, Krause M, Svitkina TM, Borisy GG, Gertler FB. Critical role of Ena/VASP proteins for filopodia formation in neurons and in function downstream of netrin-1. Neuron. 42: 37-49. PMID 15066263 DOI: 10.1016/S0896-6273(04)00108-4  0.92
2004 Ally S, Sauer NJ, Loureiro JJ, Snapper SB, Gertler FB, Goldberg MB. Shigella interactions with the actin cytoskeleton in the absence of Ena/VASP family proteins. Cellular Microbiology. 6: 355-66. PMID 15009027 DOI: 10.1046/J.1462-5822.2003.00359.X  0.92
2004 Boukhelifa M, Parast MM, Bear JE, Gertler FB, Otey CA. Palladin is a novel binding partner for Ena/VASP family members. Cell Motility and the Cytoskeleton. 58: 17-29. PMID 14983521 DOI: 10.1002/Cm.10173  0.92
2004 Gouin E, Egile C, Dehoux P, Villiers V, Adams J, Gertler F, Li R, Cossart P. The RickA protein of Rickettsia conorii activates the Arp2/3 complex Nature. 427: 457-461. PMID 14749835 DOI: 10.1038/Nature02318  0.92
2004 Lafuente EM, Carman CV, Krause M, Springer TA, Gertler FB, Boussiotis VA. RIAM, a New Rap1 Effector, Functions Downstream of Rap1 and Regulates Rap1 Localization at the Plasma Membrane and Rap1-Induced Adhesion. Blood. 104: 510-510. DOI: 10.1182/Blood.V104.11.510.510  0.4
2003 Krause M, Dent EW, Bear JE, Loureiro JJ, Gertler FB. Ena/VASP proteins: regulators of the actin cytoskeleton and cell migration. Annual Review of Cell and Developmental Biology. 19: 541-64. PMID 14570581 DOI: 10.1146/Annurev.Cellbio.19.050103.103356  0.92
2003 Dent EW, Gertler FB. Cytoskeletal dynamics and transport in growth cone motility and axon guidance. Neuron. 40: 209-27. PMID 14556705 DOI: 10.1016/S0896-6273(03)00633-0  0.92
2003 Salazar MA, Kwiatkowski AV, Pellegrini L, Cestra G, Butler MH, Rossman KL, Serna DM, Sondek J, Gertler FB, De Camilli P. Tuba, a novel protein containing bin/amphiphysin/Rvs and Dbl homology domains, links dynamin to regulation of the actin cytoskeleton. The Journal of Biological Chemistry. 278: 49031-43. PMID 14506234 DOI: 10.1074/Jbc.M308104200  0.92
2003 Auerbuch V, Loureiro JJ, Gertler FB, Theriot JA, Portnoy DA. Ena/VASP proteins contribute to Listeria monocytogenes pathogenesis by controlling temporal and spatial persistence of bacterial actin-based motility. Molecular Microbiology. 49: 1361-75. PMID 12940993 DOI: 10.1046/J.1365-2958.2003.03639.X  0.92
2003 Kwiatkowski AV, Gertler FB, Loureiro JJ. Function and regulation of Ena/VASP proteins. Trends in Cell Biology. 13: 386-92. PMID 12837609 DOI: 10.1016/S0962-8924(03)00130-2  0.92
2003 Bladt F, Aippersbach E, Gelkop S, Strasser GA, Nash P, Tafuri A, Gertler FB, Pawson T. The murine Nck SH2/SH3 adaptors are important for the development of mesoderm-derived embryonic structures and for regulating the cellular actin network. Molecular and Cellular Biology. 23: 4586-97. PMID 12808099 DOI: 10.1128/Mcb.23.13.4586-4597.2003  0.92
2003 Apostol BL, Kazantsev A, Raffioni S, Illes K, Pallos J, Bodai L, Slepko N, Bear JE, Gertler FB, Hersch S, Housman DE, Marsh JL, Thompson LM. A cell-based assay for aggregation inhibitors as therapeutics of polyglutamine-repeat disease and validation in Drosophila. Proceedings of the National Academy of Sciences of the United States of America. 100: 5950-5. PMID 12730384 DOI: 10.1073/Pnas.2628045100  0.92
2003 Rubinson DA, Dillon CP, Kwiatkowski AV, Sievers C, Yang L, Kopinja J, Rooney DL, Zhang M, Ihrig MM, McManus MT, Gertler FB, Scott ML, Van Parijs L. A lentivirus-based system to functionally silence genes in primary mammalian cells, stem cells and transgenic mice by RNA interference. Nature Genetics. 33: 401-6. PMID 12590264 DOI: 10.1038/Ng1117  0.92
2003 Hoffman LM, Nix DA, Benson B, Boot-Hanford R, Gustafsson E, Jamora C, Menzies AS, Goh KL, Jensen CC, Gertler FB, Fuchs E, Fässler R, Beckerle MC. Targeted disruption of the murine zyxin gene. Molecular and Cellular Biology. 23: 70-9. PMID 12482962 DOI: 10.1128/Mcb.23.1.70-79.2003  0.92
2003 Rubinson DA, Dillon CP, Kwiatkowski AV, Sievers C, Yang L, Kopinja J, McManus MT, Gertler FB, Scott ML, Parijs LV. Erratum: A lentivirus-based system to silence genes in primary mammalian cells, stem cells and transgenic mice by RNA interference Nature Genetics. 34: 231-231. DOI: 10.1038/ng0603-231a  0.36
2002 Krause M, Bear JE, Loureiro JJ, Gertler FB. The Ena/VASP enigma. Journal of Cell Science. 115: 4721-6. PMID 12432060 DOI: 10.1242/Jcs.00218  0.92
2002 Loureiro JJ, Rubinson DA, Bear JE, Baltus GA, Kwiatkowski AV, Gertler FB. Critical roles of phosphorylation and actin binding motifs, but not the central proline-rich region, for Ena/vasodilator-stimulated phosphoprotein (VASP) function during cell migration. Molecular Biology of the Cell. 13: 2533-46. PMID 12134088 DOI: 10.1091/Mbc.E01-10-0102  0.92
2002 Geese M, Loureiro JJ, Bear JE, Wehland J, Gertler FB, Sechi AS. Contribution of Ena/VASP proteins to intracellular motility of listeria requires phosphorylation and proline-rich core but not F-actin binding or multimerization. Molecular Biology of the Cell. 13: 2383-96. PMID 12134077 DOI: 10.1091/Mbc.E02-01-0058  0.92
2002 Bear JE, Svitkina TM, Krause M, Schafer DA, Loureiro JJ, Strasser GA, Maly IV, Chaga OY, Cooper JA, Borisy GG, Gertler FB. Antagonism between Ena/VASP proteins and actin filament capping regulates fibroblast motility. Cell. 109: 509-21. PMID 12086607 DOI: 10.1016/S0092-8674(02)00731-6  0.92
2002 Min JH, Yang H, Ivan M, Gertler F, Kaelin WG, Pavletich NP. Structure of an HIF-1alpha -pVHL complex: hydroxyproline recognition in signaling. Science (New York, N.Y.). 296: 1886-9. PMID 12004076 DOI: 10.1126/Science.1073440  0.92
2002 Goh KL, Cai L, Cepko CL, Gertler FB. Ena/VASP proteins regulate cortical neuronal positioning. Current Biology : Cb. 12: 565-9. PMID 11937025 DOI: 10.1016/S0960-9822(02)00725-X  0.92
2002 Kazantsev A, Walker HA, Slepko N, Bear JE, Preisinger E, Steffan JS, Zhu YZ, Gertler FB, Housman DE, Marsh JL, Thompson LM. A bivalent Huntingtin binding peptide suppresses polyglutamine aggregation and pathogenesis in Drosophila. Nature Genetics. 30: 367-76. PMID 11925563 DOI: 10.1038/Ng864  0.92
2002 Hwang PM, Li C, Morra M, Lillywhite J, Muhandiram DR, Gertler F, Terhorst C, Kay LE, Pawson T, Forman-Kay JD, Li SC. A 'three-pronged' binding mechanism for the SAP/SH2D1A SH2 domain: Structural basis and relevance to the XLP syndrome Embo Journal. 21: 314-323. PMID 11823424 DOI: 10.1093/Emboj/21.3.314  0.92
2001 Nash P, Tang X, Orlicky S, Chen Q, Gertler FB, Mendenhall MD, Sicheri F, Pawson T, Tyers M. Multisite phosphorylation of a CDK inhibitor sets a threshold for the onset of DNA replication. Nature. 414: 514-21. PMID 11734846 DOI: 10.1038/35107009  0.92
2001 Bear JE, Krause M, Gertler FB. Regulating cellular actin assembly. Current Opinion in Cell Biology. 13: 158-66. PMID 11248549 DOI: 10.1016/S0955-0674(00)00193-9  0.92
2000 Lanier LM, Gertler FB. Actin cytoskeleton: thinking globally, actin' locally. Current Biology : Cb. 10: R655-7. PMID 10996803 DOI: 10.1016/S0960-9822(00)00685-0  0.92
2000 Klostermann A, Lutz B, Gertler F, Behl C. The orthologous human and murine semaphorin 6A-1 proteins (SEMA6A-1/Sema6A-1) bind to the enabled/vasodilator-stimulated phosphoprotein-like protein (EVL) via a novel carboxyl-terminal zyxin-like domain Journal of Biological Chemistry. 275: 39647-39653. PMID 10993894 DOI: 10.1074/Jbc.M006316200  0.92
2000 Lambrechts A, Kwiatkowski AV, Lanier LM, Bear JE, Vandekerckhove J, Ampe C, Gertler FB. cAMP-dependent protein kinase phosphorylation of EVL, a Mena/VASP relative, regulates its interaction with actin and SH3 domains. The Journal of Biological Chemistry. 275: 36143-51. PMID 10945997 DOI: 10.1074/Jbc.M006274200  0.92
2000 Zukerberg LR, Patrick GN, Nikolic M, Humbert S, Wu CL, Lanier LM, Gertler FB, Vidal M, Van Etten RA, Tsai LH. Cables links Cdk5 and c-Abl and facilitates Cdk5 tyrosine phosphorylation, kinase upregulation, and neurite outgrowth. Neuron. 26: 633-46. PMID 10896159 DOI: 10.1016/S0896-6273(00)81200-3  0.92
2000 Bear JE, Loureiro JJ, Libova I, Fässler R, Wehland J, Gertler FB. Negative regulation of fibroblast motility by Ena/VASP proteins. Cell. 101: 717-28. PMID 10892743 DOI: 10.1016/S0092-8674(00)80884-3  0.92
2000 Krause M, Sechi AS, Konradt M, Monner D, Gertler FB, Wehland J. Fyn-binding protein (Fyb)/SLP-76-associated protein (SLAP), Ena/vasodilator-stimulated phosphoprotein (VASP) proteins and the Arp2/3 complex link T cell receptor (TCR) signaling to the actin cytoskeleton. The Journal of Cell Biology. 149: 181-94. PMID 10747096 DOI: 10.1083/Jcb.149.1.181  0.92
2000 Lanier LM, Gertler FB. From Abl to actin: Abl tyrosine kinase and associated proteins in growth cone motility. Current Opinion in Neurobiology. 10: 80-7. PMID 10679439 DOI: 10.1016/S0959-4388(99)00058-6  0.92
1999 Carl UD, Pollmann M, Orr E, Gertler FB, Chakraborty T, Wehland J. Aromatic and basic residues within the EVH1 domain of VASP specify its interaction with proline-rich ligands Current Biology. 9: 715-718. PMID 10498433 DOI: 10.1016/S0960-9822(99)80315-7  0.92
1999 Fedorov AA, Fedorov E, Gertler F, Almo SC. Structure of EVH1, a novel proline-rich ligand-binding module involved in cytoskeletal dynamics and neural function Nature Structural Biology. 6: 661-665. PMID 10404224 DOI: 10.1038/10717  0.92
1999 Howell BW, Lanier LM, Frank R, Gertler FB, Cooper JA. The disabled 1 phosphotyrosine-binding domain binds to the internalization signals of transmembrane glycoproteins and to phospholipids. Molecular and Cellular Biology. 19: 5179-88. PMID 10373567 DOI: 10.1128/Mcb.19.7.5179  0.92
1999 Laurent V, Loisel TP, Harbeck B, Wehman A, Gröbe L, Jockusch BM, Wehland J, Gertler FB, Carlier MF. Role of proteins of the Ena/VASP family in actin-based motility of Listeria monocytogenes. The Journal of Cell Biology. 144: 1245-58. PMID 10087267 DOI: 10.1083/Jcb.144.6.1245  0.92
1999 Lanier LM, Gates MA, Witke W, Menzies AS, Wehman AM, Macklis JD, Kwiatkowski D, Soriano P, Gertler FB. Mena is required for neurulation and commissure formation. Neuron. 22: 313-25. PMID 10069337 DOI: 10.1016/S0896-6273(00)81092-2  0.92
1997 Ermekova KS, Zambrano N, Linn H, Minopoli G, Gertler F, Russo T, Sudol M. The WW domain of neural protein FE65 interacts with proline-rich motifs in Mena, the mammalian homolog of Drosophila enabled Journal of Biological Chemistry. 272: 32869-32877. PMID 9407065 DOI: 10.1074/jbc.272.52.32869  0.92
1997 Niebuhr K, Ebel F, Frank R, Reinhard M, Domann E, Carl UD, Walter U, Gertler FB, Wehland J, Chakraborty T. A novel proline-rich motif present in ActA of Listeria monocytogenes and cytoskeletal proteins is the ligand for the EVH1 domain, a protein module present in the Ena/VASP family. The Embo Journal. 16: 5433-44. PMID 9312002 DOI: 10.1093/Emboj/16.17.5433  0.92
1997 Howell BW, Gertler FB, Cooper JA. Mouse disabled (mDab1): a Src binding protein implicated in neuronal development. The Embo Journal. 16: 121-32. PMID 9009273 DOI: 10.1093/Emboj/16.1.121  0.92
1996 Gertler FB, Niebuhr K, Reinhard M, Wehland J, Soriano P. Mena, a relative of VASP and Drosophila Enabled, is implicated in the control of microfilament dynamics. Cell. 87: 227-39. PMID 8861907 DOI: 10.1016/S0092-8674(00)81341-0  0.92
1995 Gertler FB, Comer AR, Juang JL, Ahern SM, Clark MJ, Liebl EC, Hoffmann FM. enabled, a dosage-sensitive suppressor of mutations in the Drosophila Abl tyrosine kinase, encodes an Abl substrate with SH3 domain-binding properties. Genes & Development. 9: 521-33. PMID 7535279 DOI: 10.1101/Gad.9.5.521  0.92
1993 Gertler FB, Hill KK, Clark MJ, Hoffmann FM. Dosage-sensitive modifiers of Drosophila abl tyrosine kinase function: prospero, a regulator of axonal outgrowth, and disabled, a novel tyrosine kinase substrate. Genes & Development. 7: 441-53. PMID 7680635 DOI: 10.1101/Gad.7.3.441  0.92
1990 Gertler FB, Doctor JS, Hoffmann FM. Genetic suppression of mutations in the Drosophila abl proto-oncogene homolog. Science (New York, N.Y.). 248: 857-60. PMID 2188361 DOI: 10.1126/Science.2188361  0.92
1990 Henkemeyer M, West SR, Gertler FB, Hoffmann FM. A novel tyrosine kinase-independent function of Drosophila abl correlates with proper subcellular localization. Cell. 63: 949-60. PMID 2175256 DOI: 10.1016/0092-8674(90)90498-4  0.92
1989 Gertler FB, Bennett RL, Clark MJ, Hoffmann FM. Drosophila abl tyrosine kinase in embryonic CNS axons: a role in axonogenesis is revealed through dosage-sensitive interactions with disabled. Cell. 58: 103-13. PMID 2502313 DOI: 10.1016/0092-8674(89)90407-8  0.92
1988 Gertler FB, Chiu CY, Richter-Mann L, Chin DJ. Developmental and metabolic regulation of the Drosophila melanogaster 3-hydroxy-3-methylglutaryl coenzyme A reductase. Molecular and Cellular Biology. 8: 2713-21. PMID 3136321 DOI: 10.1128/MCB.8.7.2713  0.92
1988 Henkemeyer MJ, Bennett RL, Gertler FB, Hoffmann FM. DNA sequence, structure, and tyrosine kinase activity of the Drosophila melanogaster Abelson proto-oncogene homolog. Molecular and Cellular Biology. 8: 843-53. PMID 2832740 DOI: 10.1128/Mcb.8.2.843  0.92
1987 Henkemeyer MJ, Gertler FB, Goodman W, Hoffmann FM. The Drosophila Abelson proto-oncogene homolog: identification of mutant alleles that have pleiotropic effects late in development. Cell. 51: 821-8. PMID 3119227 DOI: 10.1016/0092-8674(87)90105-X  0.92
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