Rainer Spanagel, Ph.D - Publications

Affiliations: 
Psychopharmacology Central Institute of Mental Health, Mannheim, Mannheim, Baden-Württemberg, Germany 
Area:
Drug addiction, alcohol, behaviour
Website:
http://www.zi-mannheim.de/index.php?id=888&type=0

226 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2019 Bernardi RE, Olevska A, Morella I, Fasano S, Santos E, Brambilla R, Spanagel R. The inhibition of RasGRF2, but not RasGRF1, alters cocaine reward in mice. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. PMID 31182637 DOI: 10.1523/JNEUROSCI.1120-18.2019  0.4
2018 Hansson AC, Gründer G, Hirth N, Noori HR, Spanagel R, Sommer WH. Dopamine and opioid systems adaptation in alcoholism revisited: Convergent evidence from positron emission tomography and postmortem studies. Neuroscience and Biobehavioral Reviews. PMID 30243576 DOI: 10.1016/j.neubiorev.2018.09.010  0.4
2018 Lingelbach K, Hach A, Bernardi RE, Spanagel R, Bading H, Bengtson CP. C-Fos marking of identified midbrain neurons co-active after nicotine administration in-vivo. The Journal of Comparative Neurology. PMID 29888787 DOI: 10.1002/cne.24471  0.4
2018 Pfarr S, Schaaf L, Reinert JK, Paul E, Herrmannsdörfer F, Roßmanith M, Kuner T, Hansson AC, Spanagel R, Körber C, Sommer WH. Choice for drug or natural reward engages largely overlapping neuronal ensembles in the infralimbic prefrontal cortex. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. PMID 29483279 DOI: 10.1523/JNEUROSCI.0026-18.2018  0.4
2018 Bazov I, Sarkisyan D, Kononenko O, Watanabe H, Yakovleva T, Hansson AC, Sommer WH, Spanagel R, Bakalkin G. Dynorphin and κ-Opioid Receptor Dysregulation in the Dopaminergic Reward System of Human Alcoholics. Molecular Neurobiology. PMID 29383684 DOI: 10.1007/s12035-017-0844-4  0.4
2017 Hansson AC, Koopmann A, Uhrig S, Bühler S, Domi E, Kiessling E, Ciccocioppo R, Froemke RC, Grinevich V, Kiefer F, Sommer WH, Vollstädt-Klein S, Spanagel R. Oxytocin Reduces Alcohol Cue-Reactivity in Alcohol Dependent Rats and Humans. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. PMID 29090683 DOI: 10.1038/npp.2017.257  0.4
2017 Vengeliene V, Bespalov A, Roßmanith M, Horschitz S, Berger S, Relo AL, Noori HR, Schneider P, Enkel T, Bartsch D, Schneider M, Behl B, Hansson AC, Schloss P, Spanagel R. Towards trans-diagnostic mechanisms in psychiatry: Neurobehavioral profile of rats with a loss of function point mutation in the dopamine transporter gene. Disease Models & Mechanisms. PMID 28167616 DOI: 10.1242/dmm.027623  0.4
2016 Uhrig S, Vandael D, Marcantoni A, Dedic N, Bilbao A, Vogt MA, Hirth N, Broccoli L, Bernardi RE, Schönig K, Gass P, Bartsch D, Spanagel R, Deussing JM, Sommer WH, et al. Differential Roles for L-Type Calcium Channel Subtypes in Alcohol Dependence. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. PMID 27905406 DOI: 10.1038/npp.2016.266  0.4
2016 Domi E, Uhrig S, Soverchia L, Spanagel R, Hansson AC, Barbier E, Heilig M, Ciccocioppo R, Ubaldi M. Genetic deletion of neuronal PPARγ enhances the emotional response to acute stress and exacerbates anxiety: An effect reversed by rescue of amygdala PPARγ function. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. PMID 27810934 DOI: 10.1523/JNEUROSCI.4127-15.2016  0.4
2016 Hermann D, Hirth N, Reimold M, Batra A, Smolka MN, Hoffmann S, Kiefer F, Noori HR, Sommer WH, Reischl G, la Fougère C, Mann K, Spanagel R, Hansson AC. Low μ-Opioid Receptor Status in Alcohol Dependence Identified by Combined Positron Emission Tomography and Post-Mortem Brain Analysis. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. PMID 27510425 DOI: 10.1038/npp.2016.145  0.4
2016 Degenhardt F, Krämer L, Frank J, Treutlein J, Heilmann-Heimbach S, Hecker J, Fier HL, Lang M, Witt SH, Koller AC, Mann K, Hoffmann S, Kiefer F, Spanagel R, Rietschel M, et al. Analysis of Rare Variants in the Alcohol Dependence Candidate Gene GATA4. Alcoholism, Clinical and Experimental Research. PMID 27374936 DOI: 10.1111/acer.13125  0.36
2016 Uhrig S, Hirth N, Broccoli L, von Wilmsdorff M, Bauer M, Sommer C, Zink M, Steiner J, Frodl T, Malchow B, Falkai P, Spanagel R, Hansson AC, Schmitt A. Reduced oxytocin receptor gene expression and binding sites in different brain regions in schizophrenia: A post-mortem study. Schizophrenia Research. PMID 27132494 DOI: 10.1016/j.schres.2016.04.019  0.36
2016 Hirth N, Meinhardt MW, Noori HR, Salgado H, Torres-Ramirez O, Uhrig S, Broccoli L, Vengeliene V, Roßmanith M, Perreau-Lenz S, Köhr G, Sommer WH, Spanagel R, Hansson AC. Convergent evidence from alcohol-dependent humans and rats for a hyperdopaminergic state in protracted abstinence. Proceedings of the National Academy of Sciences of the United States of America. PMID 26903621 DOI: 10.1073/pnas.1506012113  0.4
2016 Spanagel R, Vengeliene V, Kiefer F. Reply to: Does acamprosate really produce its anti-relapse effects via calcium? No support from the PREDICT study in human alcoholics. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 41: 661-2. PMID 26742861 DOI: 10.1038/npp.2015.263  0.36
2015 Stacey D, Lourdusamy A, Ruggeri B, Maroteaux M, Jia T, Cattrell A, Nymberg C, Banaschewski T, Bhattacharyya S, Band H, Barker G, Bokde A, Buchel C, Carvalho F, Conrod P, ... ... Spanagel R, et al. A translational systems biology approach in both animals and humans identifies a functionally related module of accumbal genes involved in the regulation of reward processing and binge drinking in males. Journal of Psychiatry & Neuroscience : Jpn. 41: 150138. PMID 26679926 DOI: 10.1503/jpn.150138  0.36
2015 Eisenhardt M, Leixner S, Luján R, Spanagel R, Bilbao A. Glutamate Receptors within the Mesolimbic Dopamine System Mediate Alcohol Relapse Behavior. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 35: 15523-38. PMID 26609150 DOI: 10.1523/JNEUROSCI.2970-15.2015  0.36
2015 Eisenhardt M, Leixner S, Spanagel R, Bilbao A. Quantification of alcohol drinking patterns in mice. Addiction Biology. PMID 26515884 DOI: 10.1111/adb.12325  0.36
2015 Schneider M, Kasanetz F, Lynch DL, Friemel CM, Lassalle O, Hurst DP, Steindel F, Monory K, Schäfer C, Miederer I, Leweke FM, Schreckenberger M, Lutz B, Reggio PH, Manzoni OJ, ... Spanagel R, et al. Enhanced Functional Activity of the Cannabinoid Type-1 Receptor Mediates Adolescent Behavior. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 35: 13975-88. PMID 26468198 DOI: 10.1523/JNEUROSCI.1937-15.2015  0.36
2015 Vulser H, Lemaitre H, Artiges E, Miranda R, Penttilä J, Struve M, Fadai T, Kappel V, Grimmer Y, Goodman R, Stringaris A, Poustka L, Conrod P, Frouin V, Banaschewski T, et al. Subthreshold Depression and Regional Brain Volumes in Young Community Adolescents. Journal of the American Academy of Child and Adolescent Psychiatry. 54: 832-40. PMID 26407493 DOI: 10.1016/j.jaac.2015.07.006  0.36
2015 Bernardi RE, Broccoli L, Spanagel R, Hansson AC. Sex differences in dopamine binding and modafinil conditioned place preference in mice. Drug and Alcohol Dependence. 155: 37-44. PMID 26342627 DOI: 10.1016/j.drugalcdep.2015.08.016  0.36
2015 Vengeliene V, Olevska A, Spanagel R. Long-lasting effect of NMDA receptor antagonist memantine on ethanol-cue association and relapse. Journal of Neurochemistry. PMID 26342155 DOI: 10.1111/jnc.13350  0.36
2015 Pfarr S, Meinhardt MW, Klee ML, Hansson AC, Vengeliene V, Schönig K, Bartsch D, Hope BT, Spanagel R, Sommer WH. Losing Control: Excessive Alcohol Seeking after Selective Inactivation of Cue-Responsive Neurons in the Infralimbic Cortex. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 35: 10750-61. PMID 26224858 DOI: 10.1523/JNEUROSCI.0684-15.2015  0.36
2015 Vengeliene V, Moeller A, Meinhardt MW, Beardsley PM, Sommer WH, Spanagel R, Bespalov A. The Calpain Inhibitor A-705253 Attenuates Alcohol-Seeking and Relapse with Low Side-Effect Profile. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. PMID 26216521 DOI: 10.1038/npp.2015.225  0.36
2015 Ojelade SA, Jia T, Rodan AR, Chenyang T, Kadrmas JL, Cattrell A, Ruggeri B, Charoen P, Lemaitre H, Banaschewski T, Büchel C, Bokde AL, Carvalho F, Conrod PJ, Flor H, ... ... Spanagel R, et al. Rsu1 regulates ethanol consumption in Drosophila and humans. Proceedings of the National Academy of Sciences of the United States of America. 112: E4085-93. PMID 26170296 DOI: 10.1073/pnas.1417222112  0.36
2015 Richiardi J, Altmann A, Milazzo AC, Chang C, Chakravarty MM, Banaschewski T, Barker GJ, Bokde AL, Bromberg U, Büchel C, Conrod P, Fauth-Bühler M, Flor H, Frouin V, Gallinat J, ... ... Spanagel R, et al. BRAIN NETWORKS. Correlated gene expression supports synchronous activity in brain networks. Science (New York, N.Y.). 348: 1241-4. PMID 26068849 DOI: 10.1126/science.1255905  0.36
2015 Spanagel R, Bohus M. Disruption of reconsolidation processes is a balancing act - can it really account for change in psychotherapy? The Behavioral and Brain Sciences. 38: e25. PMID 26050689 DOI: 10.1017/S0140525X14000405  0.36
2015 O'Leary-Barrett M, Pihl RO, Artiges E, Banaschewski T, Bokde AL, Büchel C, Flor H, Frouin V, Garavan H, Heinz A, Ittermann B, Mann K, Paillère-Martinot ML, Nees F, Paus T, et al. Personality, Attentional Biases towards Emotional Faces and Symptoms of Mental Disorders in an Adolescent Sample. Plos One. 10: e0128271. PMID 26046352 DOI: 10.1371/journal.pone.0128271  0.36
2015 Vengeliene V, Noori HR, Spanagel R. Activation of Melatonin Receptors Reduces Relapse-Like Alcohol Consumption. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 40: 2897-906. PMID 25994077 DOI: 10.1038/npp.2015.143  0.36
2015 Ruggeri B, Nymberg C, Vuoksimaa E, Lourdusamy A, Wong CP, Carvalho FM, Jia T, Cattrell A, Macare C, Banaschewski T, Barker GJ, Bokde AL, Bromberg U, Büchel C, Conrod PJ, ... ... Spanagel R, et al. Association of Protein Phosphatase PPM1G With Alcohol Use Disorder and Brain Activity During Behavioral Control in a Genome-Wide Methylation Analysis. The American Journal of Psychiatry. 172: 543-52. PMID 25982659 DOI: 10.1176/appi.ajp.2014.14030382  0.36
2015 Perreau-Lenz S, Spanagel R. Clock genes × stress × reward interactions in alcohol and substance use disorders. Alcohol (Fayetteville, N.Y.). 49: 351-7. PMID 25943583 DOI: 10.1016/j.alcohol.2015.04.003  0.36
2015 Bach P, Vollsta Dt-Klein S, Kirsch M, Hoffmann S, Jorde A, Frank J, Charlet K, Beck A, Heinz A, Walter H, Sommer WH, Spanagel R, Rietschel M, Kiefer F. Increased mesolimbic cue-reactivity in carriers of the mu-opioid-receptor gene OPRM1 A118G polymorphism predicts drinking outcome: A functional imaging study in alcohol dependent subjects. European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology. PMID 25937240 DOI: 10.1016/j.euroneuro.2015.04.013  0.36
2015 Eisenhardt M, Hansson AC, Spanagel R, Bilbao A. Chronic intermittent ethanol exposure in mice leads to an up-regulation of CRH/CRHR1 signaling. Alcoholism, Clinical and Experimental Research. 39: 752-62. PMID 25833034 DOI: 10.1111/acer.12686  0.36
2015 Kiefer F, Kirsch M, Bach P, Hoffmann S, Reinhard I, Jorde A, von der Goltz C, Spanagel R, Mann K, Loeber S, Vollstädt-Klein S. Effects of D-cycloserine on extinction of mesolimbic cue reactivity in alcoholism: a randomized placebo-controlled trial. Psychopharmacology. 232: 2353-62. PMID 25697860 DOI: 10.1007/s00213-015-3882-5  0.36
2015 Bilbao A, Robinson JE, Heilig M, Malanga CJ, Spanagel R, Sommer WH, Thorsell A. A pharmacogenetic determinant of mu-opioid receptor antagonist effects on alcohol reward and consumption: evidence from humanized mice. Biological Psychiatry. 77: 850-8. PMID 25442002 DOI: 10.1016/j.biopsych.2014.08.021  0.36
2015 Juraeva D, Treutlein J, Scholz H, Frank J, Degenhardt F, Cichon S, Ridinger M, Mattheisen M, Witt SH, Lang M, Sommer WH, Hoffmann P, Herms S, Wodarz N, Soyka M, ... ... Spanagel R, et al. XRCC5 as a risk gene for alcohol dependence: evidence from a genome-wide gene-set-based analysis and follow-up studies in Drosophila and humans. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 40: 361-71. PMID 25035082 DOI: 10.1038/npp.2014.178  0.36
2014 Bernardi RE, Spanagel R. A two-injection protocol for nicotine sensitization. Behavioural Brain Research. 275: 11-4. PMID 25192633 DOI: 10.1016/j.bbr.2014.08.048  0.36
2014 Dickie EW, Tahmasebi A, French L, Kovacevic N, Banaschewski T, Barker GJ, Bokde A, Büchel C, Conrod P, Flor H, Garavan H, Gallinat J, Gowland P, Heinz A, Ittermann B, et al. Global genetic variations predict brain response to faces. Plos Genetics. 10: e1004523. PMID 25122193 DOI: 10.1371/journal.pgen.1004523  0.36
2014 Bilbao A, Rieker C, Cannella N, Parlato R, Golda S, Piechota M, Korostynski M, Engblom D, Przewlocki R, Schütz G, Spanagel R, Parkitna JR. CREB activity in dopamine D1 receptor expressing neurons regulates cocaine-induced behavioral effects. Frontiers in Behavioral Neuroscience. 8: 212. PMID 24966820 DOI: 10.3389/fnbeh.2014.00212  0.36
2014 Bernardi RE, Spanagel R. Enhanced extinction of contextual fear conditioning in ClockΔ19 mutant mice. Behavioral Neuroscience. 128: 468-73. PMID 24865659 DOI: 10.1037/a0037020  0.36
2014 Vengeliene V, Bilbao A, Spanagel R. The alcohol deprivation effect model for studying relapse behavior: a comparison between rats and mice. Alcohol (Fayetteville, N.Y.). 48: 313-20. PMID 24811155 DOI: 10.1016/j.alcohol.2014.03.002  0.36
2014 Nymberg C, Banaschewski T, Bokde AL, Büchel C, Conrod P, Flor H, Frouin V, Garavan H, Gowland P, Heinz A, Ittermann B, Mann K, Martinot JL, Nees F, Paus T, et al. DRD2/ANKK1 polymorphism modulates the effect of ventral striatal activation on working memory performance. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 39: 2357-65. PMID 24713612 DOI: 10.1038/npp.2014.83  0.36
2014 Spanagel R, Noori HR, Heilig M. Stress and alcohol interactions: animal studies and clinical significance. Trends in Neurosciences. 37: 219-27. PMID 24636458 DOI: 10.1016/j.tins.2014.02.006  0.36
2014 Noori HR, Helinski S, Spanagel R. Cluster and meta-analyses on factors influencing stress-induced alcohol drinking and relapse in rodents. Addiction Biology. 19: 225-32. PMID 24589296 DOI: 10.1111/adb.12125  0.36
2014 Bernardi RE, Spanagel R. Basal activity level in mice predicts the initial and sensitized locomotor response to nicotine only in high responders. Behavioural Brain Research. 264: 143-50. PMID 24508239 DOI: 10.1016/j.bbr.2014.01.046  0.36
2014 Halbout B, Bernardi RE, Hansson AC, Spanagel R. Incubation of cocaine seeking following brief cocaine experience in mice is enhanced by mGluR1 blockade. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 34: 1781-90. PMID 24478360 DOI: 10.1523/JNEUROSCI.1076-14.2014  0.4
2014 Bernardi RE, Uhrig S, Spanagel R, Hansson AC. Transcriptional regulation of L-type calcium channel subtypes Cav1.2 and Cav1.3 by nicotine and their potential role in nicotine sensitization. Nicotine & Tobacco Research : Official Journal of the Society For Research On Nicotine and Tobacco. 16: 774-85. PMID 24470632 DOI: 10.1093/ntr/ntt274  0.36
2014 Jorde A, Bach P, Witt SH, Becker K, Reinhard I, Vollstädt-Klein S, Kirsch M, Hermann D, Charlet K, Beck A, Wimmer L, Frank J, Treutlein J, Spanagel R, Mann K, et al. Genetic variation in the atrial natriuretic peptide transcription factor GATA4 modulates amygdala responsiveness in alcohol dependence. Biological Psychiatry. 75: 790-7. PMID 24314346 DOI: 10.1016/j.biopsych.2013.10.020  0.36
2014 Sellmann C, Villarín Pildaín L, Schmitt A, Leonardi-Essmann F, Durrenberger PF, Spanagel R, Arzberger T, Kretzschmar H, Zink M, Gruber O, Herrera-Marschitz M, Reynolds R, Falkai P, Gebicke-Haerter PJ, Matthäus F. Gene expression in superior temporal cortex of schizophrenia patients. European Archives of Psychiatry and Clinical Neuroscience. 264: 297-309. PMID 24287731 DOI: 10.1007/s00406-013-0473-5  0.36
2014 Vengeliene V, Bessiere B, Pype J, Spanagel R. The effects of xenon and nitrous oxide gases on alcohol relapse. Alcoholism, Clinical and Experimental Research. 38: 557-63. PMID 24118055 DOI: 10.1111/acer.12264  0.36
2014 Spanagel R, Vengeliene V, Jandeleit B, Fischer WN, Grindstaff K, Zhang X, Gallop MA, Krstew EV, Lawrence AJ, Kiefer F. Acamprosate produces its anti-relapse effects via calcium. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 39: 783-91. PMID 24081303 DOI: 10.1038/npp.2013.264  0.36
2014 Schneider P, Hannusch C, Schmahl C, Bohus M, Spanagel R, Schneider M. Adolescent peer-rejection persistently alters pain perception and CB1 receptor expression in female rats. European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology. 24: 290-301. PMID 23669059 DOI: 10.1016/j.euroneuro.2013.04.004  0.36
2013 Spanagel R, Durstewitz D, Hansson A, Heinz A, Kiefer F, Köhr G, Matthäus F, Nöthen MM, Noori HR, Obermayer K, Rietschel M, Schloss P, Scholz H, Schumann G, Smolka M, et al. A systems medicine research approach for studying alcohol addiction. Addiction Biology. 18: 883-96. PMID 24283978 DOI: 10.1111/adb.12109  0.36
2013 Bernardi RE, Spanagel R. The ClockΔ19 mutation in mice fails to alter the primary and secondary reinforcing properties of nicotine. Drug and Alcohol Dependence. 133: 733-9. PMID 24054990 DOI: 10.1016/j.drugalcdep.2013.08.024  0.36
2013 Holmes A, Spanagel R, Krystal JH. Glutamatergic targets for new alcohol medications. Psychopharmacology. 229: 539-54. PMID 23995381 DOI: 10.1007/s00213-013-3226-2  0.36
2013 Brand I, Fliegel S, Spanagel R, Noori HR. Global ethanol-induced enhancements of monoaminergic neurotransmission: a meta-analysis study. Alcoholism, Clinical and Experimental Research. 37: 2048-57. PMID 23808660 DOI: 10.1111/acer.12207  0.36
2013 Noori HR, Spanagel R. Quantum modeling of common sense. The Behavioral and Brain Sciences. 36: 302. PMID 23673048 DOI: 10.1017/S0140525X1200307X  0.36
2013 Cannella N, Halbout B, Uhrig S, Evrard L, Corsi M, Corti C, Deroche-Gamonet V, Hansson AC, Spanagel R. The mGluR2/3 agonist LY379268 induced anti-reinstatement effects in rats exhibiting addiction-like behavior. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 38: 2048-56. PMID 23624743 DOI: 10.1038/npp.2013.106  0.36
2013 Meinhardt MW, Hansson AC, Perreau-Lenz S, Bauder-Wenz C, Stählin O, Heilig M, Harper C, Drescher KU, Spanagel R, Sommer WH. Rescue of infralimbic mGluR2 deficit restores control over drug-seeking behavior in alcohol dependence. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 33: 2794-806. PMID 23407939 DOI: 10.1523/JNEUROSCI.4062-12.2013  0.36
2013 Bilbao A, Blanco E, Luque-Rojas MJ, Suárez J, Palomino A, Vida M, Araos P, Bermúdez-Silva FJ, Fernández-Espejo E, Spanagel R, Rodríguez de Fonseca F. Oleoylethanolamide dose-dependently attenuates cocaine-induced behaviours through a PPARα receptor-independent mechanism. Addiction Biology. 18: 78-87. PMID 23163925 DOI: 10.1111/adb.12006  0.36
2013 Sommer W, Spanagel R. Behavioral neurobiology of alcohol addiction. Preface. Current Topics in Behavioral Neurosciences. 13: v-vii. PMID 23097780  0.36
2013 Vengeliene V, Noori HR, Spanagel R. The use of a novel drinkometer system for assessing pharmacological treatment effects on ethanol consumption in rats. Alcoholism, Clinical and Experimental Research. 37: E322-8. PMID 22757984 DOI: 10.1111/j.1530-0277.2012.01874.x  0.36
2013 Spanagel R, Vengeliene V. New pharmacological treatment strategies for relapse prevention. Current Topics in Behavioral Neurosciences. 13: 583-609. PMID 22389180 DOI: 10.1007/7854_2012_205  0.36
2013 Spanagel R, Zink M, Sommer WH. Neurobiology of alcohol addiction Neuroscience in the 21st Century: From Basic to Clinical. 2745-2773. DOI: 10.1007/978-1-4614-1997-6_107  0.36
2013 Spanagel R, Kiefer F. Neurobiology of alcohol addiction | Neurobiologie der alkoholabhängigkeit Psychopharmakotherapie. 20: 199-208.  0.36
2013 Sommer WH, Spanagel R. Preface Current Topics in Behavioral Neurosciences. 13: V-VII.  0.36
2012 Stacey D, Bilbao A, Maroteaux M, Jia T, Easton AC, Longueville S, Nymberg C, Banaschewski T, Barker GJ, Büchel C, Carvalho F, Conrod PJ, Desrivières S, Fauth-Bühler M, Fernandez-Medarde A, ... ... Spanagel R, et al. RASGRF2 regulates alcohol-induced reinforcement by influencing mesolimbic dopamine neuron activity and dopamine release. Proceedings of the National Academy of Sciences of the United States of America. 109: 21128-33. PMID 23223532 DOI: 10.1073/pnas.1211844110  0.36
2012 Noori HR, Spanagel R, Hansson AC. Neurocircuitry for modeling drug effects. Addiction Biology. 17: 827-64. PMID 22978651 DOI: 10.1111/j.1369-1600.2012.00485.x  0.36
2012 Frölich J, Banaschewski T, Spanagel R, Döpfner M, Lehmkuhl G. [The medical treatment of attention deficit hyperactivity disorder (ADHD) with amphetamines in children and adolescents]. Zeitschrift FüR Kinder- Und Jugendpsychiatrie Und Psychotherapie. 40: 287-99; quiz 299-300. PMID 22869222 DOI: 10.1024/1422-4917/a000185  0.36
2012 Noori HR, Fliegel S, Brand I, Spanagel R. The impact of acetylcholinesterase inhibitors on the extracellular acetylcholine concentrations in the adult rat brain: a meta-analysis. Synapse (New York, N.Y.). 66: 893-901. PMID 22733599 DOI: 10.1002/syn.21581  0.36
2012 Perreau-Lenz S, Vengeliene V, Noori HR, Merlo-Pich EV, Corsi MA, Corti C, Spanagel R. Inhibition of the casein-kinase-1-ε/δ/ prevents relapse-like alcohol drinking. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 37: 2121-31. PMID 22549116 DOI: 10.1038/npp.2012.62  0.36
2012 Whelan R, Conrod PJ, Poline JB, Lourdusamy A, Banaschewski T, Barker GJ, Bellgrove MA, Büchel C, Byrne M, Cummins TD, Fauth-Bühler M, Flor H, Gallinat J, Heinz A, Ittermann B, ... ... Spanagel R, et al. Adolescent impulsivity phenotypes characterized by distinct brain networks. Nature Neuroscience. 15: 920-5. PMID 22544311 DOI: 10.1038/nn.3092  0.36
2012 Berger SM, Weber T, Perreau-Lenz S, Vogt MA, Gartside SE, Maser-Gluth C, Lanfumey L, Gass P, Spanagel R, Bartsch D. A functional Tph2 C1473G polymorphism causes an anxiety phenotype via compensatory changes in the serotonergic system. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 37: 1986-98. PMID 22491354 DOI: 10.1038/npp.2012.46  0.36
2012 Schmitt A, Leonardi-Essmann F, Durrenberger PF, Wichert SP, Spanagel R, Arzberger T, Kretzschmar H, Zink M, Herrera-Marschitz M, Reynolds R, Rossner MJ, Falkai P, Gebicke-Haerter PJ. Structural synaptic elements are differentially regulated in superior temporal cortex of schizophrenia patients. European Archives of Psychiatry and Clinical Neuroscience. 262: 565-77. PMID 22441714 DOI: 10.1007/s00406-012-0306-y  0.36
2012 Brand T, Spanagel R, Schneider M. Decreased reward sensitivity in rats from the Fischer344 strain compared to Wistar rats is paralleled by differences in endocannabinoid signaling. Plos One. 7: e31169. PMID 22347447 DOI: 10.1371/journal.pone.0031169  0.36
2012 Karlsson RM, Adermark L, Molander A, Perreau-Lenz S, Singley E, Solomon M, Holmes A, Tanaka K, Lovinger DM, Spanagel R, Heilig M. Reduced alcohol intake and reward associated with impaired endocannabinoid signaling in mice with a deletion of the glutamate transporter GLAST. Neuropharmacology. 63: 181-9. PMID 22342743 DOI: 10.1016/j.neuropharm.2012.01.027  0.36
2012 Inta D, Vogt MA, Perreau-Lenz S, Schneider M, Pfeiffer N, Wojcik SM, Spanagel R, Gass P. Sensorimotor gating, working and social memory deficits in mice with reduced expression of the vesicular glutamate transporter VGLUT1. Behavioural Brain Research. 228: 328-32. PMID 22197296 DOI: 10.1016/j.bbr.2011.12.012  0.36
2012 Nees F, Tzschoppe J, Patrick CJ, Vollstädt-Klein S, Steiner S, Poustka L, Banaschewski T, Barker GJ, Büchel C, Conrod PJ, Garavan H, Heinz A, Gallinat J, Lathrop M, Mann K, ... ... Spanagel R, et al. Determinants of early alcohol use in healthy adolescents: the differential contribution of neuroimaging and psychological factors. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 37: 986-95. PMID 22113088 DOI: 10.1038/npp.2011.282  0.36
2012 Molander A, Vengeliene V, Heilig M, Wurst W, Deussing JM, Spanagel R. Brain-specific inactivation of the Crhr1 gene inhibits post-dependent and stress-induced alcohol intake, but does not affect relapse-like drinking. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 37: 1047-56. PMID 22113086 DOI: 10.1038/npp.2011.297  0.36
2012 Schneider P, Weber-Fahr W, Schweinfurth N, Ho YJ, Sartorius A, Spanagel R, Pawlak CR. Central metabolite changes and activation of microglia after peripheral interleukin-2 challenge. Brain, Behavior, and Immunity. 26: 277-83. PMID 21983278 DOI: 10.1016/j.bbi.2011.09.011  0.36
2012 Hermann D, Weber-Fahr W, Sartorius A, Hoerst M, Frischknecht U, Tunc-Skarka N, Perreau-Lenz S, Hansson AC, Krumm B, Kiefer F, Spanagel R, Mann K, Ende G, Sommer WH. Translational magnetic resonance spectroscopy reveals excessive central glutamate levels during alcohol withdrawal in humans and rats. Biological Psychiatry. 71: 1015-21. PMID 21907974 DOI: 10.1016/j.biopsych.2011.07.034  0.36
2011 Spanagel R. Why do we take drugs? From the drug-reinforcement theory to a novel concept of drug instrumentalization. The Behavioral and Brain Sciences. 34: 322. PMID 22074976 DOI: 10.1017/S0140525X11000847  0.36
2011 Helinski S, Spanagel R. Publication trends in addiction research. Addiction Biology. 16: 532-9. PMID 21929709 DOI: 10.1111/j.1369-1600.2011.00388.x  0.36
2011 Schneider P, Ho YJ, Spanagel R, Pawlak CR. A novel elevated plus-maze procedure to avoid the one-trial tolerance problem. Frontiers in Behavioral Neuroscience. 5: 43. PMID 21845176 DOI: 10.3389/fnbeh.2011.00043  0.36
2011 Karrenbauer BD, Müller CP, Ho YJ, Spanagel R, Huston JP, Schwarting RK, Pawlak CR. Time-dependent in-vivo effects of interleukin-2 on neurotransmitters in various cortices: relationships with depressive-related and anxiety-like behaviour. Journal of Neuroimmunology. 237: 23-32. PMID 21726905 DOI: 10.1016/j.jneuroim.2011.05.011  0.36
2011 Zink M, Ferbert T, Frank ST, Seufert P, Gebicke-Haerter PJ, Spanagel R. Perinatal exposure to alcohol disturbs spatial learning and glutamate transmission-related gene expression in the adult hippocampus. The European Journal of Neuroscience. 34: 457-68. PMID 21722212 DOI: 10.1111/j.1460-9568.2011.07776.x  0.36
2011 Schneider S, Peters J, Bromberg U, Brassen S, Menz MM, Miedl SF, Loth E, Banaschewski T, Barbot A, Barker G, Conrod PJ, Dalley JW, Flor H, Gallinat J, Garavan H, ... ... Spanagel R, et al. Boys do it the right way: sex-dependent amygdala lateralization during face processing in adolescents. Neuroimage. 56: 1847-53. PMID 21316467 DOI: 10.1016/j.neuroimage.2011.02.019  0.36
2011 Stickel F, Buch S, Lau K, Meyer zu Schwabedissen H, Berg T, Ridinger M, Rietschel M, Schafmayer C, Braun F, Hinrichsen H, Günther R, Arlt A, Seeger M, Müller S, Seitz HK, ... ... Spanagel R, et al. Genetic variation in the PNPLA3 gene is associated with alcoholic liver injury in caucasians. Hepatology (Baltimore, Md.). 53: 86-95. PMID 21254164 DOI: 10.1002/hep.24017  0.36
2011 Klugmann M, Klippenstein V, Leweke FM, Spanagel R, Schneider M. Cannabinoid exposure in pubertal rats increases spontaneous ethanol consumption and NMDA receptor associated protein levels. The International Journal of Neuropsychopharmacology / Official Scientific Journal of the Collegium Internationale Neuropsychopharmacologicum (Cinp). 14: 505-17. PMID 21211107 DOI: 10.1017/S1461145710001562  0.36
2011 Halbout B, Perreau-Lenz S, Dixon CI, Stephens DN, Spanagel R. Per1(Brdm1) mice self-administer cocaine and reinstate cocaine-seeking behaviour following extinction. Behavioural Pharmacology. 22: 76-80. PMID 21127416 DOI: 10.1097/FBP.0b013e328341e9ca  0.36
2011 Schmitt A, Leonardi-Essmann F, Durrenberger PF, Parlapani E, Schneider-Axmann T, Spanagel R, Arzberger T, Kretzschmar H, Herrera-Marschitz M, Gruber O, Reynolds R, Falkai P, Gebicke-Haerter PJ. Regulation of immune-modulatory genes in left superior temporal cortex of schizophrenia patients: a genome-wide microarray study. The World Journal of Biological Psychiatry : the Official Journal of the World Federation of Societies of Biological Psychiatry. 12: 201-15. PMID 21091092 DOI: 10.3109/15622975.2010.530690  0.36
2011 Kiefer F, Witt SH, Frank J, Richter A, Treutlein J, Lemenager T, Nöthen MM, Cichon S, Batra A, Berner M, Wodarz N, Zimmermann US, Spanagel R, Wiedemann K, Smolka MN, et al. Involvement of the atrial natriuretic peptide transcription factor GATA4 in alcohol dependence, relapse risk and treatment response to acamprosate. The Pharmacogenomics Journal. 11: 368-74. PMID 20585342 DOI: 10.1038/tpj.2010.51  0.36
2010 Schumann G, Loth E, Banaschewski T, Barbot A, Barker G, Büchel C, Conrod PJ, Dalley JW, Flor H, Gallinat J, Garavan H, Heinz A, Itterman B, Lathrop M, Mallik C, ... ... Spanagel R, et al. The IMAGEN study: reinforcement-related behaviour in normal brain function and psychopathology. Molecular Psychiatry. 15: 1128-39. PMID 21102431 DOI: 10.1038/mp.2010.4  0.36
2010 Spanagel R, Bartsch D, Brors B, Dahmen N, Deussing J, Eils R, Ende G, Gallinat J, Gebicke-Haerter P, Heinz A, Kiefer F, Jäger W, Mann K, Matthäus F, Nöthen M, et al. An integrated genome research network for studying the genetics of alcohol addiction. Addiction Biology. 15: 369-79. PMID 21040237 DOI: 10.1111/j.1369-1600.2010.00276.x  0.36
2010 Sommer JU, Schmitt A, Heck M, Schaeffer EL, Fendt M, Zink M, Nieselt K, Symons S, Petroianu G, Lex A, Herrera-Marschitz M, Spanagel R, Falkai P, Gebicke-Haerter PJ. Differential expression of presynaptic genes in a rat model of postnatal hypoxia: relevance to schizophrenia. European Archives of Psychiatry and Clinical Neuroscience. 260: S81-9. PMID 20945070 DOI: 10.1007/s00406-010-0159-1  0.36
2010 Umhau JC, Momenan R, Schwandt ML, Singley E, Lifshitz M, Doty L, Adams LJ, Vengeliene V, Spanagel R, Zhang Y, Shen J, George DT, Hommer D, Heilig M. Effect of acamprosate on magnetic resonance spectroscopy measures of central glutamate in detoxified alcohol-dependent individuals: a randomized controlled experimental medicine study. Archives of General Psychiatry. 67: 1069-77. PMID 20921123 DOI: 10.1001/archgenpsychiatry.2010.125  0.36
2010 Novak M, Halbout B, O'Connor EC, Rodriguez Parkitna J, Su T, Chai M, Crombag HS, Bilbao A, Spanagel R, Stephens DN, Schütz G, Engblom D. Incentive learning underlying cocaine-seeking requires mGluR5 receptors located on dopamine D1 receptor-expressing neurons. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 30: 11973-82. PMID 20826661 DOI: 10.1523/JNEUROSCI.2550-10.2010  0.36
2010 Zieker D, Jenne I, Koenigsrainer I, Zdichavsky M, Nieselt K, Buck K, Zieker J, Beckert S, Glatzle J, Spanagel R, Koenigsrainer A, Northoff H, Loeffler M. Circadian expression of clock- and tumor suppressor genes in human oral mucosa. Cellular Physiology and Biochemistry : International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology. 26: 155-66. PMID 20798499 DOI: 10.1159/000320547  0.36
2010 Friemel CM, Spanagel R, Schneider M. Reward sensitivity for a palatable food reward peaks during pubertal developmental in rats. Frontiers in Behavioral Neuroscience. 4. PMID 20700386 DOI: 10.3389/fnbeh.2010.00039  0.36
2010 Vengeliene V, Leonardi-Essmann F, Sommer WH, Marston HM, Spanagel R. Glycine transporter-1 blockade leads to persistently reduced relapse-like alcohol drinking in rats. Biological Psychiatry. 68: 704-11. PMID 20655511 DOI: 10.1016/j.biopsych.2010.05.029  0.36
2010 Brunk I, Sanchis-Segura C, Blex C, Perreau-Lenz S, Bilbao A, Spanagel R, Ahnert-Hilger G. Amphetamine regulates NR2B expression in Go2α knockout mice and thereby sustains behavioral sensitization. Journal of Neurochemistry. 115: 234-46. PMID 20649838 DOI: 10.1111/j.1471-4159.2010.06921.x  0.36
2010 Perreau-Lenz S, Sanchis-Segura C, Leonardi-Essmann F, Schneider M, Spanagel R. Development of morphine-induced tolerance and withdrawal: involvement of the clock gene mPer2. European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology. 20: 509-17. PMID 20434889 DOI: 10.1016/j.euroneuro.2010.03.006  0.36
2010 Spanagel R. A call for systems approaches in addiction research. Addiction (Abingdon, England). 105: 791-2; discussion 79. PMID 20402968 DOI: 10.1111/j.1360-0443.2009.02793.x  0.36
2010 Spanagel R. Are metabotropic glutamate receptors promising targets for the treatment of alcoholism? Biological Psychiatry. 67: 798-9. PMID 20381698 DOI: 10.1016/j.biopsych.2010.03.003  0.36
2010 Parkitna JR, Bilbao A, Rieker C, Engblom D, Piechota M, Nordheim A, Spanagel R, Schütz G. Loss of the serum response factor in the dopamine system leads to hyperactivity. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 24: 2427-35. PMID 20223941 DOI: 10.1096/fj.09-151423  0.36
2010 Enkel T, Spanagel R, Vollmayr B, Schneider M. Stress triggers anhedonia in rats bred for learned helplessness. Behavioural Brain Research. 209: 183-6. PMID 20122969 DOI: 10.1016/j.bbr.2010.01.042  0.36
2010 Enkel T, Gholizadeh D, von Bohlen Und Halbach O, Sanchis-Segura C, Hurlemann R, Spanagel R, Gass P, Vollmayr B. Ambiguous-cue interpretation is biased under stress- and depression-like states in rats. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 35: 1008-15. PMID 20043002 DOI: 10.1038/npp.2009.204  0.36
2010 Schneider M, Heise V, Spanagel R. Differential involvement of the opioid receptor antagonist naloxone in motivational and hedonic aspects of reward. Behavioural Brain Research. 208: 466-72. PMID 20035797 DOI: 10.1016/j.bbr.2009.12.013  0.36
2010 Mutschler J, Bilbao A, von der Goltz C, Demiralay C, Jahn H, Wiedemann K, Spanagel R, Kiefer F. Augmented stress-induced alcohol drinking and withdrawal in mice lacking functional natriuretic peptide-A receptors. Alcohol and Alcoholism (Oxford, Oxfordshire). 45: 13-6. PMID 19828462 DOI: 10.1093/alcalc/agp065  0.36
2009 Vengeliene V, Celerier E, Chaskiel L, Penzo F, Spanagel R. Compulsive alcohol drinking in rodents. Addiction Biology. 14: 384-96. PMID 19740366 DOI: 10.1111/j.1369-1600.2009.00177.x  0.36
2009 Zink M, Araç G, Frank ST, Gass P, Gebicke-Härter PJ, Spanagel R. Perinatal exposure to alcohol reduces the expression of complexins I and II. Neurotoxicology and Teratology. 31: 400-5. PMID 19671442 DOI: 10.1016/j.ntt.2009.08.001  0.36
2009 Zimmermann US, Winkelmann PR, Pilhatsch M, Nees JA, Spanagel R, Schulz K. Withdrawal phenomena and dependence syndrome after the consumption of "spice gold". Deutsches ÄRzteblatt International. 106: 464-7. PMID 19652769 DOI: 10.3238/arztebl.2009.0464  0.36
2009 Mameli M, Halbout B, Creton C, Engblom D, Parkitna JR, Spanagel R, Lüscher C. Cocaine-evoked synaptic plasticity: persistence in the VTA triggers adaptations in the NAc. Nature Neuroscience. 12: 1036-41. PMID 19597494 DOI: 10.1038/nn.2367  0.36
2009 Treutlein J, Cichon S, Ridinger M, Wodarz N, Soyka M, Zill P, Maier W, Moessner R, Gaebel W, Dahmen N, Fehr C, Scherbaum N, Steffens M, Ludwig KU, Frank J, ... ... Spanagel R, et al. Genome-wide association study of alcohol dependence. Archives of General Psychiatry. 66: 773-84. PMID 19581569 DOI: 10.1001/archgenpsychiatry.2009.83  0.36
2009 Perreau-Lenz S, Zghoul T, de Fonseca FR, Spanagel R, Bilbao A. Circadian regulation of central ethanol sensitivity by the mPer2 gene. Addiction Biology. 14: 253-9. PMID 19523042 DOI: 10.1111/j.1369-1600.2009.00165.x  0.36
2009 Matthäus F, Smith VA, Fogtman A, Sommer WH, Leonardi-Essmann F, Lourdusamy A, Reimers MA, Spanagel R, Gebicke-Haerter PJ. Interactive molecular networks obtained by computer-aided conversion of microarray data from brains of alcohol-drinking rats. Pharmacopsychiatry. 42: S118-28. PMID 19434550 DOI: 10.1055/s-0029-1216348  0.36
2009 von der Goltz C, Vengeliene V, Bilbao A, Perreau-Lenz S, Pawlak CR, Kiefer F, Spanagel R. Cue-induced alcohol-seeking behaviour is reduced by disrupting the reconsolidation of alcohol-related memories. Psychopharmacology. 205: 389-97. PMID 19418040 DOI: 10.1007/s00213-009-1544-1  0.36
2009 Spanagel R. Alcoholism: a systems approach from molecular physiology to addictive behavior. Physiological Reviews. 89: 649-705. PMID 19342616 DOI: 10.1152/physrev.00013.2008  0.36
2009 Karrenbauer BD, Ho YJ, Ludwig V, Löhn J, Spanagel R, Schwarting RK, Pawlak CR. Time-dependent effects of striatal interleukin-2 on open field behaviour in rats. Journal of Neuroimmunology. 208: 10-8. PMID 19201487 DOI: 10.1016/j.jneuroim.2008.12.003  0.36
2009 Spanagel R. Editorial: Addiction biology reaches new heights Addiction Biology. 14: 371-372. DOI: 10.1111/j.1369-1600.2009.00174.x  0.36
2008 Bilbao A, Parkitna JR, Engblom D, Perreau-Lenz S, Sanchis-Segura C, Schneider M, Konopka W, Westphal M, Breen G, Desrivieres S, Klugmann M, Guindalini C, Vallada H, Laranjeira R, de Fonseca FR, ... ... Spanagel R, et al. Loss of the Ca2+/calmodulin-dependent protein kinase type IV in dopaminoceptive neurons enhances behavioral effects of cocaine. Proceedings of the National Academy of Sciences of the United States of America. 105: 17549-54. PMID 19001277 DOI: 10.1073/pnas.0803959105  0.36
2008 Vengeliene V, Kiefer F, Spanagel R. D-cycloserine facilitates extinction of conditioned alcohol-seeking behaviour in rats. Alcohol and Alcoholism (Oxford, Oxfordshire). 43: 626-9. PMID 18945754 DOI: 10.1093/alcalc/agn067  0.36
2008 Engblom D, Bilbao A, Sanchis-Segura C, Dahan L, Perreau-Lenz S, Balland B, Parkitna JR, Luján R, Halbout B, Mameli M, Parlato R, Sprengel R, Lüscher C, Schütz G, Spanagel R. Glutamate receptors on dopamine neurons control the persistence of cocaine seeking. Neuron. 59: 497-508. PMID 18701074 DOI: 10.1016/j.neuron.2008.07.010  0.36
2008 Wiens F, Zitzmann A, Lachance MA, Yegles M, Pragst F, Wurst FM, von Holst D, Guan SL, Spanagel R. Chronic intake of fermented floral nectar by wild treeshrews. Proceedings of the National Academy of Sciences of the United States of America. 105: 10426-31. PMID 18663222 DOI: 10.1073/pnas.0801628105  0.36
2008 Schumann G, Johann M, Frank J, Preuss U, Dahmen N, Laucht M, Rietschel M, Rujescu D, Lourdusamy A, Clarke TK, Krause K, Dyer A, Depner M, Wellek S, Treutlein J, ... ... Spanagel R, et al. Systematic analysis of glutamatergic neurotransmission genes in alcohol dependence and adolescent risky drinking behavior. Archives of General Psychiatry. 65: 826-38. PMID 18606955 DOI: 10.1001/archpsyc.65.7.826  0.36
2008 Brunk I, Blex C, Sanchis-Segura C, Sternberg J, Perreau-Lenz S, Bilbao A, Hörtnagl H, Baron J, Juranek J, Laube G, Birnbaumer L, Spanagel R, Ahnert-Hilger G. Deletion of Go2alpha abolishes cocaine-induced behavioral sensitization by disturbing the striatal dopamine system. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 22: 3736-46. PMID 18606864 DOI: 10.1096/fj.08-111245  0.36
2008 Perreau-Lenz S, Spanagel R. The effects of drugs of abuse on clock genes. Drug News & Perspectives. 21: 211-7. PMID 18560620 DOI: 10.1358/dnp.2008.21.4.1213350  0.36
2008 Gass P, Leonardi-Essmann F, Zueger M, Spanagel R, Gebicke-Haerter PJ. Transcriptional changes in insulin- and lipid metabolism-related genes in the hippocampus of olfactory bulbectomized mice. Journal of Neuroscience Research. 86: 3184-93. PMID 18543339 DOI: 10.1002/jnr.21753  0.36
2008 Mann K, Kiefer F, Spanagel R, Littleton J. Acamprosate: recent findings and future research directions. Alcoholism, Clinical and Experimental Research. 32: 1105-10. PMID 18540918 DOI: 10.1111/j.1530-0277.2008.00690.x  0.36
2008 Hampp G, Ripperger JA, Houben T, Schmutz I, Blex C, Perreau-Lenz S, Brunk I, Spanagel R, Ahnert-Hilger G, Meijer JH, Albrecht U. Regulation of monoamine oxidase A by circadian-clock components implies clock influence on mood. Current Biology : Cb. 18: 678-83. PMID 18439826 DOI: 10.1016/j.cub.2008.04.012  0.36
2008 Raeder H, Holter SM, Hartmann AM, Spanagel R, Moller HJ, Rujescu D. Expression of N-methyl-d-aspartate (NMDA) receptor subunits and splice variants in an animal model of long-term voluntary alcohol self-administration. Drug and Alcohol Dependence. 96: 16-21. PMID 18358639 DOI: 10.1016/j.drugalcdep.2007.12.013  0.36
2008 Vengeliene V, Bilbao A, Molander A, Spanagel R. Neuropharmacology of alcohol addiction. British Journal of Pharmacology. 154: 299-315. PMID 18311194 DOI: 10.1038/bjp.2008.30  0.36
2008 Spanagel R, Kiefer F. Drugs for relapse prevention of alcoholism: ten years of progress. Trends in Pharmacological Sciences. 29: 109-15. PMID 18262663 DOI: 10.1016/j.tips.2007.12.005  0.36
2008 Schneider M, Spanagel R. Appetitive odor-cue conditioning attenuates the acoustic startle response in rats. Behavioural Brain Research. 189: 226-30. PMID 18243352 DOI: 10.1016/j.bbr.2007.12.017  0.36
2008 Frank ST, Krumm B, Spanagel R. Cocaine-induced dopamine overflow within the nucleus accumbens measured by in vivo microdialysis: a meta-analysis. Synapse (New York, N.Y.). 62: 243-52. PMID 18236471 DOI: 10.1002/syn.20489  0.36
2008 Pawlak CR, Sanchis-Segura C, Soewarto D, Wagner S, Hrabé de Angelis M, Spanagel R. A phenotype-driven ENU mutagenesis screen for the identification of dominant mutations involved in alcohol consumption. Mammalian Genome : Official Journal of the International Mammalian Genome Society. 19: 77-84. PMID 18213483 DOI: 10.1007/s00335-007-9087-4  0.36
2007 Schneider M, Spanagel R, Zhang SJ, Bading H, Klugmann M. Adeno-associated virus (AAV)-mediated suppression of Ca2+/calmodulin kinase IV activity in the nucleus accumbens modulates emotional behaviour in mice. Bmc Neuroscience. 8: 105. PMID 18053176 DOI: 10.1186/1471-2202-8-105  0.36
2007 Vengeliene V, Heidbreder CA, Spanagel R. The effects of lamotrigine on alcohol seeking and relapse. Neuropharmacology. 53: 951-7. PMID 17976664 DOI: 10.1016/j.neuropharm.2007.09.006  0.36
2007 Perreau-Lenz S, Zghoul T, Spanagel R. Clock genes running amok. Clock genes and their role in drug addiction and depression. Embo Reports. 8: S20-3. PMID 17726437 DOI: 10.1038/sj.embor.7401016  0.36
2007 Bottlender M, Spanagel R, Soyka M. [One drink, one drunk--controlled drinking by alcoholics? 3-year-outcome after intensive outpatient treatment]. Psychotherapie, Psychosomatik, Medizinische Psychologie. 57: 32-8. PMID 17357031 DOI: 10.1055/s-2006-951918  0.36
2007 Sanchis-Segura C, Cline B, Jurd R, Rudolph U, Spanagel R. Etomidate and propofol-hyposensitive GABAA receptor beta3(N265M) mice show little changes in acute alcohol sensitivity but enhanced tolerance and withdrawal. Neuroscience Letters. 416: 275-8. PMID 17350761 DOI: 10.1016/j.neulet.2007.02.024  0.36
2007 Zieker J, Zieker D, Jatzko A, Dietzsch J, Nieselt K, Schmitt A, Bertsch T, Fassbender K, Spanagel R, Northoff H, Gebicke-Haerter PJ. Differential gene expression in peripheral blood of patients suffering from post-traumatic stress disorder. Molecular Psychiatry. 12: 116-8. PMID 17252001 DOI: 10.1038/sj.mp.4001905  0.36
2007 Füllgrabe MW, Vengeliene V, Spanagel R. Influence of age at drinking onset on the alcohol deprivation effect and stress-induced drinking in female rats. Pharmacology, Biochemistry, and Behavior. 86: 320-6. PMID 17098280 DOI: 10.1016/j.pbb.2006.10.004  0.36
2007 Zghoul T, Abarca C, Sanchis-Segura C, Albrecht U, Schumann G, Spanagel R. Ethanol self-administration and reinstatement of ethanol-seeking behavior in Per1(Brdm1) mutant mice. Psychopharmacology. 190: 13-9. PMID 17051414 DOI: 10.1007/s00213-006-0592-z  0.36
2007 Spanagel R. Finding a way out of alcohol dependence | Wege aus der alkoholabhängigkeit Deutsche Apotheker Zeitung. 147: 46-51.  0.36
2007 Vollmar A, Ring J, Lau S, Niedner R, Goebels N, Abeck D, Stange E, Hatz HJ, Dingermann T, Zündorf I, Spanagel R, Batra A, Holzbach R, Pallenbach E, Probst W, et al. Interpharm Hamburg 2007 - So we like advanced training | Interpharm Hamburg 2007 - So mögen wir fortbildung Deutsche Apotheker Zeitung. 147: 54-95.  0.36
2006 Vengeliene V, Leonardi-Essmann F, Perreau-Lenz S, Gebicke-Haerter P, Drescher K, Gross G, Spanagel R. The dopamine D3 receptor plays an essential role in alcohol-seeking and relapse. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 20: 2223-33. PMID 17077299 DOI: 10.1096/fj.06-6110com  0.36
2006 Kiefer F, Spanagel R. Measuring alcohol consumption in man--it is time for a change. Addiction (Abingdon, England). 101: 1215-6; author reply. PMID 16869854 DOI: 10.1111/j.1360-0443.2006.01541.x  0.36
2006 Sanchis-Segura C, Spanagel R. Behavioural assessment of drug reinforcement and addictive features in rodents: an overview. Addiction Biology. 11: 2-38. PMID 16759333 DOI: 10.1111/j.1369-1600.2006.00012.x  0.36
2006 Spanagel R. Science meets public. Addiction Biology. 11: 1. PMID 16759332 DOI: 10.1111/j.1369-1600.2006.00008.x  0.36
2006 Treutlein J, Kissling C, Frank J, Wiemann S, Dong L, Depner M, Saam C, Lascorz J, Soyka M, Preuss UW, Rujescu D, Skowronek MH, Rietschel M, Spanagel R, Heinz A, et al. Genetic association of the human corticotropin releasing hormone receptor 1 (CRHR1) with binge drinking and alcohol intake patterns in two independent samples. Molecular Psychiatry. 11: 594-602. PMID 16550213 DOI: 10.1038/sj.mp.4001813  0.36
2006 Sanchis-Segura C, Borchardt T, Vengeliene V, Zghoul T, Bachteler D, Gass P, Sprengel R, Spanagel R. Involvement of the AMPA receptor GluR-C subunit in alcohol-seeking behavior and relapse. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 26: 1231-8. PMID 16436610 DOI: 10.1523/JNEUROSCI.4237-05.2006  0.36
2006 Zueger M, Urani A, Chourbaji S, Zacher C, Lipp HP, Albrecht U, Spanagel R, Wolfer DP, Gass P. mPer1 and mPer2 mutant mice show regular spatial and contextual learning in standardized tests for hippocampus-dependent learning. Journal of Neural Transmission (Vienna, Austria : 1996). 113: 347-56. PMID 15959842 DOI: 10.1007/s00702-005-0322-4  0.36
2005 Spanagel R, Heilig M. Addiction and its brain science. Addiction (Abingdon, England). 100: 1813-22. PMID 16367982 DOI: 10.1111/j.1360-0443.2005.01260.x  0.36
2005 Spanagel R, Rosenwasser AM, Schumann G, Sarkar DK. Alcohol consumption and the body's biological clock. Alcoholism, Clinical and Experimental Research. 29: 1550-7. PMID 16156052 DOI: 10.1097/01.alc.0000175074.70807.fd  0.36
2005 Zieker D, Fehrenbach E, Dietzsch J, Fliegner J, Waidmann M, Nieselt K, Gebicke-Haerter P, Spanagel R, Simon P, Niess AM, Northoff H. cDNA microarray analysis reveals novel candidate genes expressed in human peripheral blood following exhaustive exercise. Physiological Genomics. 23: 287-94. PMID 16118270 DOI: 10.1152/physiolgenomics.00096.2005  0.36
2005 Siegmund S, Vengeliene V, Singer MV, Spanagel R. Influence of age at drinking onset on long-term ethanol self-administration with deprivation and stress phases. Alcoholism, Clinical and Experimental Research. 29: 1139-45. PMID 16046868 DOI: 10.1097/01.ALC.0000171928.40418.46  0.36
2005 Chourbaji S, Zacher C, Sanchis-Segura C, Spanagel R, Gass P. Social and structural housing conditions influence the development of a depressive-like phenotype in the learned helplessness paradigm in male mice. Behavioural Brain Research. 164: 100-6. PMID 16046006 DOI: 10.1016/j.bbr.2005.06.003  0.36
2005 Sanchis-Segura C, Spanagel R, Henn FA, Vollmayr B. Reduced sensitivity to sucrose in rats bred for helplessness: a study using the matching law. Behavioural Pharmacology. 16: 267-70. PMID 15961967 DOI: 10.1097/01.fbp.0000171772.61669.6f  0.36
2005 Strekalova T, Spanagel R, Dolgov O, Bartsch D. Stress-induced hyperlocomotion as a confounding factor in anxiety and depression models in mice. Behavioural Pharmacology. 16: 171-80. PMID 15864072 DOI: 10.1097/00008877-200505000-00006  0.36
2005 Vengeliene V, Bachteler D, Danysz W, Spanagel R. The role of the NMDA receptor in alcohol relapse: a pharmacological mapping study using the alcohol deprivation effect. Neuropharmacology. 48: 822-9. PMID 15829254 DOI: 10.1016/j.neuropharm.2005.01.002  0.36
2005 Zink M, Spanagel R. Ethanol induces GAD67 and VGAT in slice cultures of newborn rat cerebral cortex. Neuroreport. 16: 377-80. PMID 15729141 DOI: 10.1097/00001756-200503150-00014  0.36
2005 Vengeliene V, Vollmayr B, Henn FA, Spanagel R. Voluntary alcohol intake in two rat lines selectively bred for learned helpless and non-helpless behavior. Psychopharmacology. 178: 125-32. PMID 15719228 DOI: 10.1007/s00213-004-2013-5  0.36
2005 Leonardi-Essmann F, Emig M, Kitamura Y, Spanagel R, Gebicke-Haerter PJ. Fractalkine-upregulated milk-fat globule EGF factor-8 protein in cultured rat microglia. Journal of Neuroimmunology. 160: 92-101. PMID 15710462 DOI: 10.1016/j.jneuroim.2004.11.012  0.36
2005 Bachteler D, Economidou D, Danysz W, Ciccocioppo R, Spanagel R. The effects of acamprosate and neramexane on cue-induced reinstatement of ethanol-seeking behavior in rat. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 30: 1104-10. PMID 15668725 DOI: 10.1038/sj.npp.1300657  0.36
2005 Spanagel R, Pendyala G, Abarca C, Zghoul T, Sanchis-Segura C, Magnone MC, Lascorz J, Depner M, Holzberg D, Soyka M, Schreiber S, Matsuda F, Lathrop M, Schumann G, Albrecht U. The clock gene Per2 influences the glutamatergic system and modulates alcohol consumption. Nature Medicine. 11: 35-42. PMID 15608650 DOI: 10.1038/nm1163  0.36
2005 Soyka M, Bottlender M, Spanagel R. For and against: Controlled drinking as useful and necessary treatment alternative. Against | Pro und kontra; Kontrolliertes trinken als sinnvolle und notwendige behandlungsoption. Kontra Psychiatrische Praxis. 32: 325-326.  0.36
2004 Werner C, Raivich G, Cowen M, Strekalova T, Sillaber I, Buters JT, Spanagel R, Hofmann F. Importance of NO/cGMP signalling via cGMP-dependent protein kinase II for controlling emotionality and neurobehavioural effects of alcohol. The European Journal of Neuroscience. 20: 3498-506. PMID 15610182 DOI: 10.1111/j.1460-9568.2004.03793.x  0.36
2004 Zink M, Schmitt A, Vengeliene V, Henn FA, Spanagel R. Ethanol induces expression of the glutamate transporters EAAT1 and EAAT2 in organotypic cortical slice cultures. Alcoholism, Clinical and Experimental Research. 28: 1752-7. PMID 15547463 DOI: 10.1097/01.ALC.0000145810.12545.B3  0.36
2004 Schroff KC, Cowen MS, Koch S, Spanagel R. Strain-specific responses of inbred mice to ethanol following food shortage. Addiction Biology. 9: 265-71. PMID 15511722 DOI: 10.1080/13556210412331292596  0.36
2004 Strekalova T, Spanagel R, Bartsch D, Henn FA, Gass P. Stress-induced anhedonia in mice is associated with deficits in forced swimming and exploration. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 29: 2007-17. PMID 15266352 DOI: 10.1038/sj.npp.1300532  0.36
2004 Littleton JM, De Witte P, Litten R, Gessa GL, Spanagel R, Kranzler H, Lehert P, Johnson B, Saunders J, Berglund M, Harris A, Anton R, Mann K. Challenges to medications development in treating alcohol dependence: an international perspective. Alcohol and Alcoholism (Oxford, Oxfordshire). 39: 271-5. PMID 15208155 DOI: 10.1093/alcalc/agh067  0.36
2004 Sanchis-Segura C, Cline BH, Marsicano G, Lutz B, Spanagel R. Reduced sensitivity to reward in CB1 knockout mice. Psychopharmacology. 176: 223-32. PMID 15083252 DOI: 10.1007/s00213-004-1877-8  0.36
2004 Vollmayr B, Bachteler D, Vengeliene V, Gass P, Spanagel R, Henn F. Rats with congenital learned helplessness respond less to sucrose but show no deficits in activity or learning. Behavioural Brain Research. 150: 217-21. PMID 15033295 DOI: 10.1016/S0166-4328(03)00259-6  0.36
2004 Bäckström P, Bachteler D, Koch S, Hyytiä P, Spanagel R. mGluR5 antagonist MPEP reduces ethanol-seeking and relapse behavior. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 29: 921-8. PMID 14735132 DOI: 10.1038/sj.npp.1300381  0.36
2003 Spanagel R, Mann K. [Acamprosate--new preclinical research aspects]. Mmw Fortschritte Der Medizin. 145: 61-4. PMID 15490768  0.36
2003 Siegmund S, Spanagel R, Singer MV. Role of the brain-gut axis in alcohol-related gastrointestinal diseases--what can we learn from new animal models? Journal of Physiology and Pharmacology : An Official Journal of the Polish Physiological Society. 54: 191-207. PMID 15075460  0.36
2003 Schumann G, Rujescu D, Kissling C, Soyka M, Dahmen N, Preuss UW, Wieman S, Depner M, Wellek S, Lascorz J, Bondy B, Giegling I, Anghelescu I, Cowen MS, Poustka A, ... Spanagel R, et al. Analysis of genetic variations of protein tyrosine kinase fyn and their association with alcohol dependence in two independent cohorts. Biological Psychiatry. 54: 1422-6. PMID 14675807 DOI: 10.1016/S0006-3223(03)00635-8  0.36
2003 Fleischmann A, Hvalby O, Jensen V, Strekalova T, Zacher C, Layer LE, Kvello A, Reschke M, Spanagel R, Sprengel R, Wagner EF, Gass P. Impaired long-term memory and NR2A-type NMDA receptor-dependent synaptic plasticity in mice lacking c-Fos in the CNS. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 23: 9116-22. PMID 14534245  0.36
2003 Cowen MS, Schumann G, Yagi T, Spanagel R. Role of Fyn tyrosine kinase in ethanol consumption by mice. Alcoholism, Clinical and Experimental Research. 27: 1213-9. PMID 12966312 DOI: 10.1097/01.ALC.0000081630.14159.02  0.36
2003 Spanagel R. [The role of the glutamatergic system in alcohol addiction]. Fortschritte Der Neurologie-Psychiatrie. 71: S33-5. PMID 12947541 DOI: 10.1055/s-2003-40503  0.36
2003 Vengeliene V, Siegmund S, Singer MV, Sinclair JD, Li TK, Spanagel R. A comparative study on alcohol-preferring rat lines: effects of deprivation and stress phases on voluntary alcohol intake. Alcoholism, Clinical and Experimental Research. 27: 1048-54. PMID 12878910 DOI: 10.1097/01.ALC.0000075829.81211.0C  0.36
2003 Cowen MS, Schroff KC, Gass P, Sprengel R, Spanagel R. Neurobehavioral effects of alcohol in AMPA receptor subunit (GluR1) deficient mice. Neuropharmacology. 45: 325-33. PMID 12871650 DOI: 10.1016/S0028-3908(03)00174-6  0.36
2003 Kratzer U, Spanagel R, Schmidt WJ. The effect of acamprosate on the development of morphine-induced behavioral sensitization in rats. Behavioural Pharmacology. 14: 351-6. PMID 12838041 DOI: 10.1097/01.fbp.0000080417.18561.77  0.36
2003 Spanagel R. Alcohol addiction research: from animal models to clinics. Best Practice & Research. Clinical Gastroenterology. 17: 507-18. PMID 12828952 DOI: 10.1016/S1521-6918(03)00031-3  0.36
2003 Deroche-Gamonet V, Sillaber I, Aouizerate B, Izawa R, Jaber M, Ghozland S, Kellendonk C, Le Moal M, Spanagel R, Schütz G, Tronche F, Piazza PV. The glucocorticoid receptor as a potential target to reduce cocaine abuse. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 23: 4785-90. PMID 12805318  0.36
2003 Schumann G, Spanagel R, Mann K. Candidate genes for alcohol dependence: animal studies. Alcoholism, Clinical and Experimental Research. 27: 880-8. PMID 12766634 DOI: 10.1097/01.ALC.0000065437.18136.86  0.36
2003 Schumann G, Rujescu D, Szegedi A, Singer P, Wiemann S, Wellek S, Giegling I, Klawe C, Anghelescu I, Heinz A, Spanagel R, Mann K, Henn FA, Dahmen N. No association of alcohol dependence with a NMDA-receptor 2B gene variant. Molecular Psychiatry. 8: 11-2. PMID 12556902 DOI: 10.1038/sj.mp.4001245  0.36
2003 Spanagel R, Sanchis-Segura C. The use of transgenic mice to study addictive behavior Clinical Neuroscience Research. 3: 325-331. DOI: 10.1016/S1566-2772(03)00094-X  0.36
2003 Spanagel R. News from preclinical addiction research: Genomic alterations in the nucleus accumbens following heroin self-adminisitration | Neues aus der präklinischen suchtforschung: Genomische veränderungen im nucleus accumbens nach heroinselbstverabreichung Sucht. 49: 239-240.  0.36
2002 Spanagel R, Siegmund S, Cowen M, Schroff KC, Schumann G, Fiserova M, Sillaber I, Wellek S, Singer M, Putzke J. The neuronal nitric oxide synthase gene is critically involved in neurobehavioral effects of alcohol. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 22: 8676-83. PMID 12351742  0.36
2002 Kirschke C, Schadrack J, Zieglgänsberger W, Spanagel R. Effects of morphine withdrawal on micro-opioid receptor-stimulated guanylyl 5'-[gamma-[35S]thio]-triphosphate autoradiography in rat brain. European Journal of Pharmacology. 446: 43-51. PMID 12098584 DOI: 10.1016/S0014-2999(02)01763-6  0.36
2002 Abarca C, Albrecht U, Spanagel R. Cocaine sensitization and reward are under the influence of circadian genes and rhythm. Proceedings of the National Academy of Sciences of the United States of America. 99: 9026-30. PMID 12084940 DOI: 10.1073/pnas.142039099  0.36
2002 Henniger MS, Spanagel R, Wigger A, Landgraf R, Hölter SM. Alcohol self-administration in two rat lines selectively bred for extremes in anxiety-related behavior. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 26: 729-36. PMID 12007743 DOI: 10.1016/S0893-133X(01)00408-0  0.36
2002 Sillaber I, Rammes G, Zimmermann S, Mahal B, Zieglgänsberger W, Wurst W, Holsboer F, Spanagel R. Enhanced and delayed stress-induced alcohol drinking in mice lacking functional CRH1 receptors. Science (New York, N.Y.). 296: 931-3. PMID 11988580 DOI: 10.1126/science.1069836  0.36
2001 Boening JA, Lesch OM, Spanagel R, Wolffgramm J, Narita M, Sinclair D, Mason BJ, Wiesbeck GA. Pharmacological relapse prevention in alcohol dependence: from animal models to clinical trials. Alcoholism, Clinical and Experimental Research. 25: 127S-131S. PMID 11391061  0.36
2001 Li TK, Spanagel R, Colombo G, McBride WJ, Porrino LJ, Suzuki T, Rodd-Henricks ZA. Alcohol reinforcement and voluntary ethanol consumption. Alcoholism, Clinical and Experimental Research. 25: 117S-126S. PMID 11391060  0.36
2001 Matsumoto I, Wilce PA, Buckley T, Dodd P, Puzke J, Spanagel R, Zieglgansberger W, Wolf G, Leng S, Rommelspacher H, Finckh U, Schmidt LG. Ethanol and gene expression in brain. Alcoholism, Clinical and Experimental Research. 25: 82S-86S. PMID 11391055  0.36
2001 Rammes G, Mahal B, Putzke J, Parsons C, Spielmanns P, Pestel E, Spanagel R, Zieglgänsberger W, Schadrack J. The anti-craving compound acamprosate acts as a weak NMDA-receptor antagonist, but modulates NMDA-receptor subunit expression similar to memantine and MK-801. Neuropharmacology. 40: 749-60. PMID 11369029 DOI: 10.1016/S0028-3908(01)00008-9  0.36
2001 Azad SC, Marsicano G, Eberlein I, Putzke J, Zieglgänsberger W, Spanagel R, Lutz B. Differential role of the nitric oxide pathway on delta(9)-THC-induced central nervous system effects in the mouse. The European Journal of Neuroscience. 13: 561-8. PMID 11168564 DOI: 10.1046/j.1460-9568.2001.01431.x  0.36
2001 Schumann G, Rujescu D, Szegedi A, Singer P, Wiemann S, Klawe C, Anghelescu I, Giegling I, Wellek S, Heinz A, Spanagel R, Mann K, Henn FA, Dahmen N. Alcohol dependence is associated with a NMDA-receptor 2B gene variant American Journal of Medical Genetics - Neuropsychiatric Genetics. 105: 631.  0.36
2001 Spanagel R. Drug memory and addiction memory: Results from animal studies | Gibt es ein drogen- und suchtgedächtnis? Hinweise aus tierexperimentellen untersuchung Sucht. 47: 365-367.  0.36
2000 Hölter SM, Henniger MS, Lipkowski AW, Spanagel R. Kappa-opioid receptors and relapse-like drinking in long-term ethanol-experienced rats. Psychopharmacology. 153: 93-102. PMID 11255932 DOI: 10.1007/s002130000601  0.36
2000 Spanagel R. Recent animal models of alcoholism. Alcohol Research & Health : the Journal of the National Institute On Alcohol Abuse and Alcoholism. 24: 124-31. PMID 11199279  0.36
2000 Spanagel R, Hölter SM. Pharmacological validation of a new animal model of alcoholism. Journal of Neural Transmission (Vienna, Austria : 1996). 107: 669-80. PMID 10943907  0.36
2000 Henniger MS, Ohl F, Hölter SM, Weissenbacher P, Toschi N, Lörscher P, Wigger A, Spanagel R, Landgraf R. Unconditioned anxiety and social behaviour in two rat lines selectively bred for high and low anxiety-related behaviour. Behavioural Brain Research. 111: 153-63. PMID 10840141 DOI: 10.1016/S0166-4328(00)00151-0  0.36
2000 Hölter SM, Linthorst AC, Reul JM, Spanagel R. Withdrawal symptoms in a long-term model of voluntary alcohol drinking in Wistar rats. Pharmacology, Biochemistry, and Behavior. 66: 143-51. PMID 10837854 DOI: 10.1016/S0091-3057(00)00196-9  0.36
1999 Spanagel R, Weiss F. The dopamine hypothesis of reward: past and current status. Trends in Neurosciences. 22: 521-7. PMID 10529820 DOI: 10.1016/S0166-2236(99)01447-2  0.36
1999 Stöhr T, Almeida OF, Landgraf R, Shippenberg TS, Holsboer F, Spanagel R. Stress- and corticosteroid-induced modulation of the locomotor response to morphine in rats. Behavioural Brain Research. 103: 85-93. PMID 10475168 DOI: 10.1016/S0166-4328(99)00027-3  0.36
1999 Rupprecht R, Koch M, Montkowski A, Lancel M, Faulhaber J, Harting J, Spanagel R. Assessment of neuroleptic-like properties of progesterone. Psychopharmacology. 143: 29-38. PMID 10227077 DOI: 10.1007/s002130050916  0.36
1998 Spanagel R, Sillaber I, Zieglgänsberger W, Corrigall WA, Stewart J, Shaham Y. Acamprosate suppresses the expression of morphine-induced sensitization in rats but does not affect heroin self-administration or relapse induced by heroin or stress. Psychopharmacology. 139: 391-401. PMID 9809860 DOI: 10.1007/s002130050730  0.36
1998 Darstein M, Albrecht C, López-Francos L, Knörle R, Hölter SM, Spanagel R, Feuerstein TJ. Release and accumulation of neurotransmitters in the rat brain: acute effects of ethanol in vitro and effects of long-term voluntary ethanol intake. Alcoholism, Clinical and Experimental Research. 22: 704-9. PMID 9622453  0.36
1998 Timpl P, Spanagel R, Sillaber I, Kresse A, Reul JM, Stalla GK, Blanquet V, Steckler T, Holsboer F, Wurst W. Impaired stress response and reduced anxiety in mice lacking a functional corticotropin-releasing hormone receptor 1. Nature Genetics. 19: 162-6. PMID 9620773 DOI: 10.1038/520  0.36
1995 Shoaib M, Spanagel R, Stohr T, Shippenberg TS. Strain differences in the rewarding and dopamine-releasing effects of morphine in rats. Psychopharmacology. 117: 240-7. PMID 7753973 DOI: 10.1007/BF02245193  0.36
1994 Shoaib M, Spanagel R. Mesolimbic sites mediate the discriminative stimulus effects of morphine. European Journal of Pharmacology. 252: 69-75. PMID 8149996 DOI: 10.1016/0014-2999(94)90576-2  0.36
1994 Spanagel R, Shoaib M. Involvement of mesolimbic kappa-opioid systems in the discriminative stimulus effects of morphine. Neuroscience. 63: 797-804. PMID 7898679 DOI: 10.1016/0306-4522(94)90524-X  0.36
1994 Spanagel R, Almeida OF, Bartl C, Shippenberg TS. Endogenous kappa-opioid systems in opiate withdrawal: role in aversion and accompanying changes in mesolimbic dopamine release. Psychopharmacology. 115: 121-7. PMID 7862883 DOI: 10.1007/BF02244761  0.36
1994 Spanagel R, Almeida OF, Shippenberg TS. Evidence that nor-binaltorphimine can function as an antagonist at multiple opioid receptor subtypes. European Journal of Pharmacology. 264: 157-62. PMID 7851478 DOI: 10.1016/0014-2999(94)00449-8  0.36
1993 Spanagel R, Shippenberg TS. Modulation of morphine-induced sensitization by endogenous kappa opioid systems in the rat. Neuroscience Letters. 153: 232-6. PMID 8392157 DOI: 10.1016/0304-3940(93)90329-J  0.36
1993 Spanagel R, Almeida OF, Shippenberg TS. Long lasting changes in morphine-induced mesolimbic dopamine release after chronic morphine exposure. Synapse (New York, N.Y.). 14: 243-5. PMID 8211708 DOI: 10.1002/syn.890140307  0.36
1992 Herz A, Shippenberg TS, Bals-Kubik R, Spanagel R. [Opiate addiction. Pharmacologic and biochemical aspects]. Arzneimittel-Forschung. 42: 256-9. PMID 1586396  0.36
1992 Spanagel R, Herz A, Shippenberg TS. Opposing tonically active endogenous opioid systems modulate the mesolimbic dopaminergic pathway. Proceedings of the National Academy of Sciences of the United States of America. 89: 2046-50. PMID 1347943  0.36
1992 Shippenberg TS, Herz A, Spanagel R, Bals-Kubik R, Stein C. Conditioning of opioid reinforcement: neuroanatomical and neurochemical substrates. Annals of the New York Academy of Sciences. 654: 347-56. PMID 1321576  0.36
1991 Spanagel R, Herz A, Bals-Kubik R, Shippenberg TS. Beta-endorphin-induced locomotor stimulation and reinforcement are associated with an increase in dopamine release in the nucleus accumbens. Psychopharmacology. 104: 51-6. PMID 1882003 DOI: 10.1007/BF02244553  0.36
1991 Spanagel R, Herz A, Shippenberg TS. Modulation of the mesolimbic dopaminergic system by beta-endorphin-(1-27) as assessed by microdialysis. European Journal of Pharmacology. 200: 319-24. PMID 1782993 DOI: 10.1016/0014-2999(91)90589-I  0.36
1990 Spanagel R, Herz A, Shippenberg TS. Identification of the opioid receptor types mediating beta-endorphin-induced alterations in dopamine release in the nucleus accumbens. European Journal of Pharmacology. 190: 177-84. PMID 1981749 DOI: 10.1016/0014-2999(90)94124-G  0.36
1990 Spanagel R, Herz A, Shippenberg TS. The effects of opioid peptides on dopamine release in the nucleus accumbens: an in vivo microdialysis study. Journal of Neurochemistry. 55: 1734-40. PMID 1976759  0.36
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