David C. Gadsby - Publications

Affiliations: 
Rockefeller University, New York, NY, United States 
Area:
General Biophysics, Biochemistry, Neuroscience Biology

98 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2015 Chaves LA, Gadsby DC. Cysteine accessibility probes timing and extent of NBD separation along the dimer interface in gating CFTR channels. The Journal of General Physiology. 145: 261-83. PMID 25825169 DOI: 10.1085/jgp.201411347  0.64
2014 Vedovato N, Gadsby DC. Route, mechanism, and implications of proton import during Na+/K+ exchange by native Na+/K+-ATPase pumps. The Journal of General Physiology. 143: 449-64. PMID 24688018 DOI: 10.1085/jgp.201311148  0.64
2012 Gadsby DC, Bezanilla F, Rakowski RF, De Weer P, Holmgren M. The dynamic relationships between the three events that release individual Na⁺ ions from the Na⁺/K⁺-ATPase. Nature Communications. 3: 669. PMID 22334072 DOI: 10.1038/ncomms1673  0.64
2011 Castillo JP, De Giorgis D, Basilio D, Gadsby DC, Rosenthal JJ, Latorre R, Holmgren M, Bezanilla F. Energy landscape of the reactions governing the Na+ deeply occluded state of the Na+/K+-ATPase in the giant axon of the Humboldt squid. Proceedings of the National Academy of Sciences of the United States of America. 108: 20556-61. PMID 22143771 DOI: 10.1073/pnas.1116439108  0.64
2011 Csanády L, Vergani P, Gulyás-Kovács A, Gadsby DC. Electrophysiological, biochemical, and bioinformatic methods for studying CFTR channel gating and its regulation. Methods in Molecular Biology (Clifton, N.J.). 741: 443-69. PMID 21594801 DOI: 10.1007/978-1-61779-117-8_28  0.64
2010 Vedovato N, Gadsby DC. The two C-terminal tyrosines stabilize occluded Na/K pump conformations containing Na or K ions. The Journal of General Physiology. 136: 63-82. PMID 20548052 DOI: 10.1085/jgp.201010407  0.64
2010 Csanády L, Vergani P, Gadsby DC. Strict coupling between CFTR's catalytic cycle and gating of its Cl- ion pore revealed by distributions of open channel burst durations. Proceedings of the National Academy of Sciences of the United States of America. 107: 1241-6. PMID 19966305 DOI: 10.1073/pnas.0911061107  0.64
2009 Takeuchi A, Reyes N, Artigas P, Gadsby DC. Visualizing the mapped ion pathway through the Na,K-ATPase pump. Channels (Austin, Tex.). 3: 383-6. PMID 19806033  0.64
2009 Gadsby DC. Ion channels versus ion pumps: the principal difference, in principle. Nature Reviews. Molecular Cell Biology. 10: 344-52. PMID 19339978 DOI: 10.1038/nrm2668  0.64
2009 Gadsby DC, Takeuchi A, Artigas P, Reyes N. Review. Peering into an ATPase ion pump with single-channel recordings. Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences. 364: 229-38. PMID 18986966 DOI: 10.1098/rstb.2008.0243  0.64
2009 Ashcroft F, Gadsby D, Miller C. Introduction. The blurred boundary between channels and transporters: We dedicate this volume to the memory of Peter Läuger, a pioneer of the link between channels and pumps Philosophical Transactions of the Royal Society B: Biological Sciences. 364: 145-147. PMID 18957372 DOI: 10.1098/rstb.2008.0245  0.64
2008 Takeuchi A, Reyes N, Artigas P, Gadsby DC. The ion pathway through the opened Na(+),K(+)-ATPase pump. Nature. 456: 413-6. PMID 18849964 DOI: 10.1038/nature07350  0.64
2007 Gadsby DC. Structural biology: ion pumps made crystal clear. Nature. 450: 957-9. PMID 18075569 DOI: 10.1038/450957a  0.64
2007 Rakowski RF, Artigas P, Palma F, Holmgren M, De Weer P, Gadsby DC. Sodium flux ratio in Na/K pump-channels opened by palytoxin. The Journal of General Physiology. 130: 41-54. PMID 17562821 DOI: 10.1085/jgp.200709770  0.64
2006 Csanády L, Nairn AC, Gadsby DC. Thermodynamics of CFTR channel gating: a spreading conformational change initiates an irreversible gating cycle. The Journal of General Physiology. 128: 523-33. PMID 17043148 DOI: 10.1085/jgp.200609558  0.64
2006 Mense M, Vergani P, White DM, Altberg G, Nairn AC, Gadsby DC. In vivo phosphorylation of CFTR promotes formation of a nucleotide-binding domain heterodimer. The Embo Journal. 25: 4728-39. PMID 17036051 DOI: 10.1038/sj.emboj.7601373  0.64
2006 Reyes N, Gadsby DC. Ion permeation through the Na+,K+-ATPase. Nature. 443: 470-4. PMID 17006516 DOI: 10.1038/nature05129  0.64
2006 Artigas P, Gadsby DC. Ouabain affinity determining residues lie close to the Na/K pump ion pathway. Proceedings of the National Academy of Sciences of the United States of America. 103: 12613-8. PMID 16894161 DOI: 10.1073/pnas.0602720103  0.64
2006 Gadsby DC, Vergani P, Csanády L. The ABC protein turned chloride channel whose failure causes cystic fibrosis. Nature. 440: 477-83. PMID 16554808 DOI: 10.1038/nature04712  0.64
2005 Vergani P, Basso C, Mense M, Nairn AC, Gadsby DC. Control of the CFTR channel's gates. Biochemical Society Transactions. 33: 1003-7. PMID 16246032 DOI: 10.1042/BST20051003  0.64
2005 Vergani P, Lockless SW, Nairn AC, Gadsby DC. CFTR channel opening by ATP-driven tight dimerization of its nucleotide-binding domains. Nature. 433: 876-80. PMID 15729345 DOI: 10.1038/nature03313  0.64
2005 Csanády L, Seto-Young D, Chan KW, Cenciarelli C, Angel BB, Qin J, McLachlin DT, Krutchinsky AN, Chait BT, Nairn AC, Gadsby DC. Preferential phosphorylation of R-domain Serine 768 dampens activation of CFTR channels by PKA. The Journal of General Physiology. 125: 171-86. PMID 15657296 DOI: 10.1085/jgp.200409076  0.64
2005 Csanády L, Chan KW, Nairn AC, Gadsby DC. Functional roles of nonconserved structural segments in CFTR's NH2-terminal nucleotide binding domain. The Journal of General Physiology. 125: 43-55. PMID 15596536 DOI: 10.1085/jgp.200409174  0.64
2004 Artigas P, Gadsby DC. Large diameter of palytoxin-induced Na/K pump channels and modulation of palytoxin interaction by Na/K pump ligands. The Journal of General Physiology. 123: 357-76. PMID 15024043 DOI: 10.1085/jgp.200308964  0.64
2004 Gadsby DC. Ion transport: spot the difference. Nature. 427: 795-7. PMID 14985745 DOI: 10.1038/427795a  0.64
2003 Basso C, Vergani P, Nairn AC, Gadsby DC. Prolonged nonhydrolytic interaction of nucleotide with CFTR's NH2-terminal nucleotide binding domain and its role in channel gating. The Journal of General Physiology. 122: 333-48. PMID 12939393 DOI: 10.1085/jgp.200308798  0.64
2003 Artigas P, Gadsby DC. Ion occlusion/deocclusion partial reactions in individual palytoxin-modified Na/K pumps. Annals of the New York Academy of Sciences. 986: 116-26. PMID 12763784  0.64
2003 Artigas P, Gadsby DC. Na+/K+-pump ligands modulate gating of palytoxin-induced ion channels. Proceedings of the National Academy of Sciences of the United States of America. 100: 501-5. PMID 12518045 DOI: 10.1073/pnas.0135849100  0.64
2003 Vergani P, Nairn AC, Gadsby DC. On the mechanism of MgATP-dependent gating of CFTR Cl- channels. The Journal of General Physiology. 121: 17-36. PMID 12508051 DOI: 10.1085/jgp.20028673  0.64
2002 Artigas P, Gadsby DC. Ion channel-like properties of the Na+/K+ Pump. Annals of the New York Academy of Sciences. 976: 31-40. PMID 12502531  0.64
2002 Dousmanis AG, Nairn AC, Gadsby DC. Distinct Mg(2+)-dependent steps rate limit opening and closing of a single CFTR Cl(-) channel. The Journal of General Physiology. 119: 545-59. PMID 12034762 DOI: 10.1085/jgp.20028594  0.64
2002 Rakowski RF, Gadsby DC, De Weer P. Single ion occupancy and steady-state gating of Na channels in squid giant axon. The Journal of General Physiology. 119: 235-49. PMID 11865020 DOI: 10.1085/jgp.119.3.235  0.64
2001 De Weer P, Gadsby DC, Rakowski RF. Voltage dependence of the apparent affinity for external Na+ of the backward-running sodium pump Journal of General Physiology. 117: 315-328. PMID 11279252 DOI: 10.1085/jgp.117.4.315  0.64
2000 Csanády L, Chan KW, Seto-Young D, Kopsco DC, Nairn AC, Gadsby DC. Severed channels probe regulation of gating of cystic fibrosis transmembrane conductance regulator by its cytoplasmic domains. The Journal of General Physiology. 116: 477-500. PMID 10962022 DOI: 10.1085/jgp.116.3.477  0.64
2000 Chan KW, Csanády L, Seto-Young D, Nairn AC, Gadsby DC. Severed molecules functionally define the boundaries of the cystic fibrosis transmembrane conductance regulator's NH(2)-terminal nucleotide binding domain. The Journal of General Physiology. 116: 163-80. PMID 10919864 DOI: 10.1085/jgp.116.2.163  0.64
2000 Holmgren M, Wagg J, Bezanilla F, Rakowski RF, De Weer P, Gadsby DC. Three distinct and sequential steps in the release of sodium ions by the Na+/K+-ATPase. Nature. 403: 898-901. PMID 10706288 DOI: 10.1038/35002599  0.64
2000 Gadsby DC. The 53rd annual meeting and symposium of the Society of General Physiologists: New Optical Methods in Cell Physiology Journal of General Physiology. 115: 223-226. DOI: 10.1085/jgp.115.2.223  0.64
1999 Csanády L, Gadsby DC. CFTR channel gating: incremental progress in irreversible steps. The Journal of General Physiology. 114: 49-53. PMID 10398691 DOI: 10.1085/jgp.114.1.49  0.64
1999 Gadsby DC, Nairn AC. Regulation of CFTR Cl- ion channels by phosphorylation and dephosphorylation. Advances in Second Messenger and Phosphoprotein Research. 33: 79-106. PMID 10218115  0.64
1999 Gadsby DC, Nairn AC. Control of CFTR channel gating by phosphorylation and nucleotide hydrolysis. Physiological Reviews. 79: S77-S107. PMID 9922377  0.64
1998 Gadsby DC, Dousmanis AG, Nairn AC. ATP hydrolysis cycles and the gating of CFTR Cl- channels. Acta Physiologica Scandinavica. Supplementum. 643: 247-56. PMID 9789567  0.64
1997 Senior AE, Gadsby DC. ATP hydrolysis cycles and mechanism in P-glycoprotein and CFTR Seminars in Cancer Biology. 8: 143-150. PMID 9441944 DOI: 10.1006/scbi.1997.0065  0.64
1997 Wagg J, Gadsby DC. Ordered interaction of ions with Na/K-pump may confound interpretation of unidirectional fluxes Annals of the New York Academy of Sciences. 834: 426-431. PMID 9405837 DOI: 10.1111/j.1749-6632.1997.tb52290.x  0.64
1997 Rakowski RF, Bezanilla F, De Weer P, Gadsby DC, Holmgren M, Wagg J. Charge translocation by the Na/K pump. Annals of the New York Academy of Sciences. 834: 231-43. PMID 9405811 DOI: 10.1111/j.1749-6632.1997.tb52254.x  0.64
1997 Rakowski RF, Gadsby DC, De Weer P. Voltage dependence of the Na/K pump Journal of Membrane Biology. 155: 105-112. PMID 9049104 DOI: 10.1007/s002329900162  0.64
1997 Beauge LA, Gadsby DC, Garrahan PJ. VIIIth International Conference on the Na/K-ATPase (and related transport ATPases), Mar del Plata, Argentina, August 26-30 1996: Introduction Annals of the New York Academy of Sciences. 834. DOI: 10.1111/j.1749-6632.1997.tb52219.x  0.64
1996 Gadsby DC. Two-bit anion channel really shapes up Nature. 383: 295-296. PMID 8848037 DOI: 10.1038/383295a0  0.64
1995 Gadsby DC, Nagel G, Hwang TC. The CFTR chloride channel of mammalian heart Annual Review of Physiology. 57: 387-416. PMID 7539989  0.64
1994 Gadsby DC, Hwang TC, Baukrowitz T, Nagel G, Horie M, Nairn AC. Regulation of CFTR channel gating. The Japanese Journal of Physiology. 44: S183-92. PMID 7752525  0.64
1994 Gadsby DC, Nairn AC. Regulation of CFTR channel gating. Trends in Biochemical Sciences. 19: 513-8. PMID 7531880 DOI: 10.1016/0968-0004(94)90141-4  0.64
1994 Hwang TC, Nagel G, Nairn AC, Gadsby DC. Regulation of the gating of cystic fibrosis transmembrane conductance regulator C1 channels by phosphorylation and ATP hydrolysis. Proceedings of the National Academy of Sciences of the United States of America. 91: 4698-702. PMID 7515176 DOI: 10.1073/pnas.91.11.4698  0.64
1994 Baukrowitz T, Hwang TC, Nairn AC, Gadsby DC. Coupling of CFTR Cl- channel gating to an ATP hydrolysis cycle. Neuron. 12: 473-82. PMID 7512348 DOI: 10.1016/0896-6273(94)90206-2  0.64
1994 Hwang TC, Gadsby DC. Chloride ion channels in mammalian heart cells Current Topics in Membranes. 42: 317-346. DOI: 10.1016/S0070-2161(08)60826-6  0.64
1994 Gadsby DC, Hwang TC, Nagel G, Baukrowitz T, Horie M, Nairn AC. Function of CFTR (cystic fibrosis transmembrane conductance regulator) chloride channels expressed in mammalian cardiac myocytes Japanese Heart Journal. 35: 63-68.  0.64
1993 Gadsby DC, Hwang TC, Horie M, Nagel G, Nairn AC. Cardiac chloride channels: incremental regulation by phosphorylation/dephosphorylation. Annals of the New York Academy of Sciences. 707: 259-74. PMID 9137557  0.64
1993 Hwang TC, Horie M, Gadsby DC. Functionally distinct phospho-forms underlie incremental activation of protein kinase-regulated Cl- conductance in mammalian heart Journal of General Physiology. 101: 629-650. PMID 7687643  0.64
1993 Gadsby DC, Rakowski RF, De Weer P. Extracellular access to the Na,K pump: Pathway similar to ion channel Science. 260: 100-103. PMID 7682009  0.64
1992 Hwang TC, Horie M, Nairn AC, Gadsby DC. Role of GTP-binding proteins in the regulation of mammalian cardiac chloride conductance. The Journal of General Physiology. 99: 465-89. PMID 1375958  0.64
1992 Gadsby DC, Horie M, Makita T, Zang WJ, Suzuki H, Kawai C. On the mechanism of beta-adrenergic activation of cardiac outward currents--chloride and delayed rectifier potassium conductance Japanese Circulation Journal. 56: 1344-1348. PMID 1337921  0.64
1992 Horie M, Hwang TC, Gadsby DC. Pipette GTP is essential for receptor-mediated regulation of Cl- current in dialysed myocytes from guinea-pig ventricle Journal of Physiology. 455: 235-246. PMID 1336550 DOI: 10.1113/jphysiol.1992.sp019299  0.64
1992 Gadsby DC, Nakao M, Bahinski A, Nagel G, Suenson M. Charge movements via the cardiac Na,K-ATPase Acta Physiologica Scandinavica, Supplement. 146: 111-123. PMID 1333148  0.64
1992 Nagel G, Hwang TC, Nastiuk KL, Nairn AC, Gadsby DC. The protein kinase A-regulated cardiac Cl- channel resembles the cystic fibrosis transmembrane conductance regulator. Nature. 360: 81-4. PMID 1279437 DOI: 10.1038/360081a0  0.64
1992 Horie M, Tzyh-Chang H, Gadsby DC. Intra-pipette GTP prevents the rapid rundown of β-adrenoceptor-mediated activation of Cl current in isolated guinea-pig ventricular myocytes Journal of Physiology. 446.  0.64
1991 Gadsby DC, Noda M, Shepherd RN, Nakao M. Influence of external monovalent cations on Na-Ca exchange current-voltage relationships in cardiac myocytes Annals of the New York Academy of Sciences. 639: 140-146. PMID 1785837  0.64
1991 Gadsby DC, Nakao M, Bahinski A. Voltage-induced Na/K pump charge movements in dialyzed heart cells Society of General Physiologists Series. 46: 355-371. PMID 1653992  0.64
1989 Nakao M, Gadsby DC. [Na] and [K] dependence of the Na/K pump current-voltage relationship in guinea pig ventricular myocytes Journal of General Physiology. 94: 539-565. PMID 2607334  0.64
1989 Gadsby DC, Nakao M. Steady-state current-voltage relationship of the Na/K pump in guinea pig ventricular myocytes Journal of General Physiology. 94: 511-537. PMID 2607333  0.64
1989 Gadsby DC, Nakao M, Bahinski A. Voltage dependence of transient and steady-state Na/K pump currents in myocytes Molecular and Cellular Biochemistry. 89: 141-146. PMID 2554121 DOI: 10.1007/BF00220766  0.64
1989 Rakowski RF, Gadsby DC, De Weer P. Stoichiometry and voltage dependence of the sodium pump in voltage-clamped, internally dialyzed squid giant axon Journal of General Physiology. 93: 903-941. PMID 2544655  0.64
1989 Bahinski A, Nairn AC, Greengard P, Gadsby DC. Chloride conductance regulated by cyclic AMP-dependent protein kinase in cardiac myocytes Nature. 340: 718-721. PMID 2475783  0.64
1989 Gadsby DC, Bahinski A, Nakao M. Chapter 14 Voltage Dependence of Na/K Pump Current Current Topics in Membranes and Transport. 34: 269-288. DOI: 10.1016/S0070-2161(08)60018-0  0.64
1988 De Weer P, Gadsby DC, Rakowski RF. Voltage dependence of the Na-K pump Annual Review of Physiology. 50: 225-241. PMID 3288092  0.64
1988 De Weer P, Gadsby DC, Rakowski RF. Overview: stoichiometry and voltage dependence of the Na/K pump Progress in Clinical and Biological Research. 268: 421-434. PMID 2843888  0.64
1988 Bahinski A, Nakao M, Gadsby DC. Potassium translocation by the Na+/K+ pump is voltage insensitive Proceedings of the National Academy of Sciences of the United States of America. 85: 3412-3416. PMID 2835771  0.64
1986 Nakao M, Gadsby DC. Voltage dependence of Na translocation by the Na/K pump Nature. 323: 628-630. PMID 2430183 DOI: 10.1038/323628a0  0.64
1985 Gadsby DC, Kimura J, Noma A. Voltage dependence of Na/K pump current in isolated heart cells Nature. 315: 63-65. PMID 2581143 DOI: 10.1038/315063a0  0.64
1985 Gadsby DC. Influence of Na/K pump current on action potentials in Purkinje fibers Advances in Myocardiology. 5: 279-294. PMID 2578681  0.64
1984 Gadsby DC. The Na/K pump of cardiac cells Annual Review of Biophysics and Bioengineering. 13: 373-398. PMID 6331287  0.64
1984 Gadsby DC. Influence of the sodium pump current on electrical activity of cardiac cells Society of General Physiologists Series. 38: 215-238. PMID 6320459  0.64
1983 Boyden PA, Cranefield PF, Gadsby DC. Noradrenaline hyperpolarizes cells of the canine coronary sinus by increasing their permeability to potassium ions The Journal of Physiology. 339: 185-206. PMID 6887022 DOI: 10.1113/jphysiol.1983.sp014711  0.64
1983 Boyden PA, Cranefield PF, Gadsby DC, Wit AL. The basis for the membrane potential of quiescent cells of the canine coronary sinus The Journal of Physiology. 339: 161-183. PMID 6887021 DOI: 10.1113/jphysiol.1983.sp014710  0.64
1983 Gadsby DC. β-Adrenoceptor agonists increase membrane K+ conductance in cardiac Purkinje fibres Nature. 306: 691-693. PMID 6140641 DOI: 10.1038/306691a0  0.64
1982 Gadsby DC. Chapter 2 Hyperpolarization of Frog Skeletal Muscle Fibers and of Canine Cardiac Purkinje Fibers during Enhanced Na+-K+ Exchange: Extracellular K+ Depletion or Increased Pump Current? Current Topics in Membranes and Transport. 16: 17-34. DOI: 10.1016/S0070-2161(08)60692-9  0.64
1982 Gadsby DC, Glitsch HG. Change in membrane current mediated by α-adrenoceptors in canine cardiac Purkinje fibres Journal of Physiology 0.64
1982 Nishiye H, Cranefield PF, Gadsby DC. Transient depolarization of atrial fibers following exposure to acetylcholine Biophysical Journal. 37.  0.64
1981 Wit AL, Cranefield PF, Gadsby DC. Electrogenic sodium extrusion can stop triggered activity in the canine coronary sinus Circulation Research. 49: 1029-1042. PMID 7273354  0.64
1981 Gadsby DC, Cranefield PF. Isoproterenol hyperpolarization of canine cardiac Purkinje fibers is not mediated by enhanced Na+/K+ pump activity Biophysical Journal. 33.  0.64
1981 Cranefield PF, Gadsby DC. Isoprenaline increases the potassium permeability of the resting membrane of canine cardiac Purkinje fibres Journal of Physiology 0.64
1981 Boyden PA, Gadsby DC, Cranefield PF. Mechanism of norepinephrine hyperpolarization of canine coronary sinus cells Biophysical Journal. 33.  0.64
1980 Gadsby DC. Activation of electrogenic Na+/K+ exchange by extracellular K+ in canine cardiac Purkinje fibers Proceedings of the National Academy of Sciences of the United States of America. 77: 4035-4039. PMID 6254009  0.64
1980 Boyden PA, Gadsby DC, Wit AL, Cranefield PF. Hyperpolarization and arrhythmias induced by norepinephrine (NE) in triggerable fibers of the canine coronary sinus Circulation. 62.  0.64
1980 Colatsky TJ, Gadsby DC. Is tetrodotoxin block of background sodium channels in canine cardiac Purkinje fibres voltage-dependent? Journal of Physiology 0.64
1979 Gadsby DC, Cranefield PF. Electrogenic sodium extrusion in cardiac Purkinje fibers Journal of General Physiology. 73: 819-837. PMID 479817  0.64
1979 Gadsby DC, Cranefield PF. Direct measurement of changes in sodium pump current in canine cardiac Purkinje fibers Proceedings of the National Academy of Sciences of the United States of America. 76: 1783-1787. PMID 287018  0.64
1978 Gadsby DC, Wit AL, Cranefield PF. The effects of acetylcholine on the electrical activity of canine cardiac Purkinje fibers Circulation Research. 43: 29-35. PMID 657457  0.64
1977 Gadsby DC, Cranefield PF. Two levels of resting potential in cardiac Purkinje fibers Journal of General Physiology. 70: 725-746. PMID 591921  0.64
1977 Gadsby DC, Niedergerke R, Ogden DC. The dual nature of the membrane potential increase associated with the activity of the sodium/potassium exchange pump in skeletal muscle fibres. Proceedings of the Royal Society of London. Series B, Biological Sciences. 198: 463-72. PMID 21401  0.64
1971 Gadsby DC, Niedergerke R, Page S. Do intracellular concentrations of potassium or sodium regulate the strength of the heart beat? Nature. 232: 651-3. PMID 4937403 DOI: 10.1038/232651a0  0.64
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