Lora K. Heisler, PhD - Publications

Pharmacology University of Cambridge, Cambridge, England, United Kingdom 
obesity, serotonin, neuroscience

62 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2018 Chakera AJ, Hurst PS, Spyer G, Ogunnowo-Bada EO, Marsh WJ, Riches CH, Yueh CY, Markkula SP, Dalley JW, Cox RD, Macdonald IA, Amiel SA, MacLeod KM, Heisler LK, Hattersley AT, et al. Molecular reductions in glucokinase activity increase counter-regulatory responses to hypoglycemia in mice and humans with diabetes. Molecular Metabolism. PMID 30146176 DOI: 10.1016/j.molmet.2018.08.001  0.4
2017 Heisler LK, Lam DD. An appetite for life: brain regulation of hunger and satiety. Current Opinion in Pharmacology. 37: 100-106. PMID 29107871 DOI: 10.1016/j.coph.2017.09.002  0.64
2017 Burke LK, Ogunnowo-Bada E, Georgescu T, Cristiano C, de Morentin PBM, Valencia Torres L, D'Agostino G, Riches C, Heeley N, Ruan Y, Rubinstein M, Low MJ, Myers MG, Rochford JJ, Evans ML, ... Heisler LK, et al. Lorcaserin improves glycemic control via a melanocortin neurocircuit. Molecular Metabolism. 6: 1092-1102. PMID 29031711 DOI: 10.1016/j.molmet.2017.07.004  0.44
2016 Garfield AS, Davies JR, Burke LK, Furby HV, Wilkinson LS, Heisler LK, Isles AR. Increased alternate splicing of Htr2c in a mouse model for Prader-Willi syndrome leads disruption of 5HT2C receptor mediated appetite. Molecular Brain. 9: 95. PMID 27931246 DOI: 10.1186/s13041-016-0277-4  0.4
2016 Markkula SP, Lyons D, Yueh CY, Riches C, Hurst P, Fielding B, Heisler LK, Evans ML. Intracerebroventricular Catalase Reduces Hepatic Insulin Sensitivity and Increases Responses to Hypoglycemia in Rats. Endocrinology. en20152054. PMID 27740870 DOI: 10.1210/en.2015-2054  0.4
2016 Xu P, He Y, Cao X, Valencia-Torres L, Yan X, Saito K, Wang C, Yang Y, Hinton A, Zhu L, Shu G, Myers MG, Wu Q, Tong Q, Heisler LK, et al. Activation of Serotonin 2C Receptors in Dopamine Neurons Inhibits Binge-like Eating in Mice. Biological Psychiatry. PMID 27516377 DOI: 10.1016/j.biopsych.2016.06.005  0.52
2016 Martin-Gronert MS, Stocker CJ, Wargent ET, Cripps RL, Garfield AS, Jovanovic Z, D'Agostino G, Yeo GS, Cawthorne MA, Arch JR, Heisler LK, Ozanne SE. 5-HT2A and 5-HT2C receptors as hypothalamic targets of developmental programming in male rats. Development (Cambridge, England). 143: e1.2. PMID 27095498 DOI: 10.1242/dev.138396  0.4
2016 Burke LK, Doslikova B, D'Agostino G, Greenwald-Yarnell M, Georgescu T, Chianese R, Martinez de Morentin PB, Ogunnowo-Bada E, Cansell C, Valencia-Torres L, Garfield AS, Apergis-Schoute J, Lam DD, Speakman JR, Rubinstein M, ... ... Heisler LK, et al. Sex difference in physical activity, energy expenditure and obesity driven by a subpopulation of hypothalamic POMC neurons. Molecular Metabolism. 5: 245-52. PMID 26977396 DOI: 10.1016/j.molmet.2016.01.005  0.64
2016 D'Agostino G, Lyons DJ, Cristiano C, Burke LK, Madara JC, Campbell JN, Garcia AP, Land BB, Lowell BB, Dileone RJ, Heisler LK. Appetite controlled by a cholecystokinin nucleus of the solitary tract to hypothalamus neurocircuit. Elife. 5. PMID 26974347 DOI: 10.7554/eLife.12225  0.96
2016 Martin-Gronert MS, Stocker CJ, Wargent ET, Cripps RL, Garfield AS, Jovanovic Z, D'Agostino G, Yeo GS, Cawthorne MA, Arch JR, Heisler LK, Ozanne SE. 5-HT2A and 5-HT2C receptors as hypothalamic targets of developmental programming in male rats. Disease Models & Mechanisms. PMID 26769798 DOI: 10.1242/dmm.023903  0.96
2014 Garfield AS, Shah BP, Madara JC, Burke LK, Patterson CM, Flak J, Neve RL, Evans ML, Lowell BB, Myers MG, Heisler LK. A parabrachial-hypothalamic cholecystokinin neurocircuit controls counterregulatory responses to hypoglycemia. Cell Metabolism. 20: 1030-7. PMID 25470549 DOI: 10.1016/j.cmet.2014.11.006  0.96
2014 Flak JN, Patterson CM, Garfield AS, D'Agostino G, Goforth PB, Sutton AK, Malec PA, Wong JM, Germani M, Jones JC, Rajala M, Satin L, Rhodes CJ, Olson DP, Kennedy RT, ... Heisler LK, et al. Leptin-inhibited PBN neurons enhance responses to hypoglycemia in negative energy balance. Nature Neuroscience. 17: 1744-50. PMID 25383904 DOI: 10.1038/nn.3861  0.96
2014 Burke LK, Doslikova B, D'Agostino G, Garfield AS, Farooq G, Burdakov D, Low MJ, Rubinstein M, Evans ML, Billups B, Heisler LK. 5-HT obesity medication efficacy via POMC activation is maintained during aging. Endocrinology. 155: 3732-8. PMID 25051442 DOI: 10.1210/en.2014-1223  0.96
2014 Cowley M, Garfield AS, Madon-Simon M, Charalambous M, Clarkson RW, Smalley MJ, Kendrick H, Isles AR, Parry AJ, Carney S, Oakey RJ, Heisler LK, Moorwood K, Wolf JB, Ward A. Developmental programming mediated by complementary roles of imprinted Grb10 in mother and pup. Plos Biology. 12: e1001799. PMID 24586114 DOI: 10.1371/journal.pbio.1001799  0.96
2014 Garfield AS, Burke LK, Shaw J, Evans ML, Heisler LK. Distribution of cells responsive to 5-HT₆ receptor antagonist-induced hypophagia. Behavioural Brain Research. 266: 201-6. PMID 24566060 DOI: 10.1016/j.bbr.2014.02.018  0.96
2013 Stanley S, Domingos AI, Kelly L, Garfield A, Damanpour S, Heisler L, Friedman J. Profiling of Glucose-Sensing Neurons Reveals that GHRH Neurons Are Activated by Hypoglycemia. Cell Metabolism. 18: 596-607. PMID 24093682 DOI: 10.1016/j.cmet.2013.09.002  0.96
2013 Doslikova B, Garfield AS, Shaw J, Evans ML, Burdakov D, Billups B, Heisler LK. 5-HT2C receptor agonist anorectic efficacy potentiated by 5-HT1B receptor agonist coapplication: an effect mediated via increased proportion of pro-opiomelanocortin neurons activated. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 33: 9800-4. PMID 23739976 DOI: 10.1523/JNEUROSCI.4326-12.2013  0.96
2012 Garfield AS, Chan WS, Dennis RJ, Ito D, Heisler LK, Rochford JJ. Neuroanatomical characterisation of the expression of the lipodystrophy and motor-neuropathy gene Bscl2 in adult mouse brain. Plos One. 7: e45790. PMID 23049863 DOI: 10.1371/journal.pone.0045790  0.96
2012 Yeo GS, Heisler LK. Unraveling the brain regulation of appetite: lessons from genetics. Nature Neuroscience. 15: 1343-9. PMID 23007189 DOI: 10.1038/nn.3211  0.96
2012 Garfield AS, Patterson C, Skora S, Gribble FM, Reimann F, Evans ML, Myers MG, Heisler LK. Neurochemical characterization of body weight-regulating leptin receptor neurons in the nucleus of the solitary tract. Endocrinology. 153: 4600-7. PMID 22869346 DOI: 10.1210/en.2012-1282  0.96
2012 Hurst P, Garfield AS, Marrow C, Heisler LK, Evans ML. Recurrent hypoglycemia is associated with loss of activation in rat brain cingulate cortex. Endocrinology. 153: 1908-14. PMID 22396449 DOI: 10.1210/en.2011-1827  0.96
2012 Begriche K, Marston OJ, Rossi J, Burke LK, McDonald P, Heisler LK, Butler AA. Melanocortin-3 receptors are involved in adaptation to restricted feeding. Genes, Brain, and Behavior. 11: 291-302. PMID 22353545 DOI: 10.1111/j.1601-183X.2012.00766.x  0.96
2012 Osundiji MA, Lam DD, Shaw J, Yueh CY, Markkula SP, Hurst P, Colliva C, Roda A, Heisler LK, Evans ML. Brain glucose sensors play a significant role in the regulation of pancreatic glucose-stimulated insulin secretion. Diabetes. 61: 321-8. PMID 22210318 DOI: 10.2337/db11-1050  0.96
2011 Rochford JJ, Myers MG, Heisler LK. Setting the tone: reactive oxygen species and the control of appetitive melanocortin neurons. Cell Metabolism. 14: 573-4. PMID 22055500 DOI: 10.1016/j.cmet.2011.10.004  0.96
2011 Marston OJ, Hurst P, Evans ML, Burdakov DI, Heisler LK. Neuropeptide Y cells represent a distinct glucose-sensing population in the lateral hypothalamus. Endocrinology. 152: 4046-52. PMID 21914773 DOI: 10.1210/en.2011-1307  0.96
2011 Lam DD, Leinninger GM, Louis GW, Garfield AS, Marston OJ, Leshan RL, Scheller EL, Christensen L, Donato J, Xia J, Evans ML, Elias C, Dalley JW, Burdakov DI, Myers MG, ... Heisler LK, et al. Leptin does not directly affect CNS serotonin neurons to influence appetite. Cell Metabolism. 13: 584-91. PMID 21531340 DOI: 10.1016/j.cmet.2011.03.016  0.96
2011 Zhou L, Yueh CY, Lam DD, Shaw J, Osundiji M, Garfield AS, Evans M, Heisler LK. Glucokinase inhibitor glucosamine stimulates feeding and activates hypothalamic neuropeptide Y and orexin neurons. Behavioural Brain Research. 222: 274-8. PMID 21440571 DOI: 10.1016/j.bbr.2011.03.043  0.96
2011 Marston OJ, Garfield AS, Heisler LK. Role of central serotonin and melanocortin systems in the control of energy balance. European Journal of Pharmacology. 660: 70-9. PMID 21216242 DOI: 10.1016/j.ejphar.2010.12.024  0.96
2011 Osundiji MA, Hurst P, Moore SP, Markkula SP, Yueh CY, Swamy A, Hoashi S, Shaw JS, Riches CH, Heisler LK, Evans ML. Recurrent hypoglycemia increases hypothalamic glucose phosphorylation activity in rats. Metabolism: Clinical and Experimental. 60: 550-6. PMID 20667558 DOI: 10.1016/j.metabol.2010.05.009  0.96
2010 Xu Y, Jones JE, Lauzon DA, Anderson JG, Balthasar N, Heisler LK, Zinn AR, Lowell BB, Elmquist JK. A serotonin and melanocortin circuit mediates D-fenfluramine anorexia. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 30: 14630-4. PMID 21048120 DOI: 10.1523/JNEUROSCI.5412-09.2010  0.96
2010 Lam DD, Garfield AS, Marston OJ, Shaw J, Heisler LK. Brain serotonin system in the coordination of food intake and body weight. Pharmacology, Biochemistry, and Behavior. 97: 84-91. PMID 20837046 DOI: 10.1016/j.pbb.2010.09.003  0.96
2010 Stanley S, Pinto S, Segal J, Pérez CA, Viale A, DeFalco J, Cai X, Heisler LK, Friedman JM. Identification of neuronal subpopulations that project from hypothalamus to both liver and adipose tissue polysynaptically. Proceedings of the National Academy of Sciences of the United States of America. 107: 7024-9. PMID 20351287 DOI: 10.1073/pnas.1002790107  0.96
2010 Osundiji MA, Zhou L, Shaw J, Moore SP, Yueh CY, Sherwin R, Heisler LK, Evans ML. Brain glucosamine boosts protective glucoprivic feeding. Endocrinology. 151: 1499-508. PMID 20179264 DOI: 10.1210/en.2009-0989  0.96
2010 Przydzial MJ, Garfield AS, Lam DD, Moore SP, Evans ML, Heisler LK. Nutritional state influences Nociceptin/Orphanin FQ peptide receptor expression in the dorsal raphe nucleus. Behavioural Brain Research. 206: 313-7. PMID 19765615 DOI: 10.1016/j.bbr.2009.09.017  0.96
2009 Alon T, Zhou L, Pérez CA, Garfield AS, Friedman JM, Heisler LK. Transgenic mice expressing green fluorescent protein under the control of the corticotropin-releasing hormone promoter. Endocrinology. 150: 5626-32. PMID 19854866 DOI: 10.1210/en.2009-0881  0.96
2009 Garfield AS, Lam DD, Marston OJ, Przydzial MJ, Heisler LK. Role of central melanocortin pathways in energy homeostasis. Trends in Endocrinology and Metabolism: Tem. 20: 203-15. PMID 19541496 DOI: 10.1016/j.tem.2009.02.002  0.96
2009 Marston OJ, Heisler LK. Targeting the serotonin 2C receptor for the treatment of obesity and type 2 diabetes. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 34: 252-3. PMID 19079077 DOI: 10.1038/npp.2008.169  0.96
2009 Garfield AS, Heisler LK. Pharmacological targeting of the serotonergic system for the treatment of obesity. The Journal of Physiology. 587: 49-60. PMID 19029184 DOI: 10.1113/jphysiol.2008.164152  0.96
2009 Lam DD, Zhou L, Vegge A, Xiu PY, Christensen BT, Osundiji MA, Yueh CY, Evans ML, Heisler LK. Distribution and neurochemical characterization of neurons within the nucleus of the solitary tract responsive to serotonin agonist-induced hypophagia. Behavioural Brain Research. 196: 139-43. PMID 18762217 DOI: 10.1016/j.bbr.2008.07.039  0.96
2008 Kumar KG, Trevaskis JL, Lam DD, Sutton GM, Koza RA, Chouljenko VN, Kousoulas KG, Rogers PM, Kesterson RA, Thearle M, Ferrante AW, Mynatt RL, Burris TP, Dong JZ, Halem HA, ... ... Heisler LK, et al. Identification of adropin as a secreted factor linking dietary macronutrient intake with energy homeostasis and lipid metabolism. Cell Metabolism. 8: 468-81. PMID 19041763 DOI: 10.1016/j.cmet.2008.10.011  0.96
2008 Xu Y, Jones JE, Kohno D, Williams KW, Lee CE, Choi MJ, Anderson JG, Heisler LK, Zigman JM, Lowell BB, Elmquist JK. 5-HT2CRs expressed by pro-opiomelanocortin neurons regulate energy homeostasis. Neuron. 60: 582-9. PMID 19038216 DOI: 10.1016/j.neuron.2008.09.033  0.96
2008 Przydzial MJ, Heisler LK. Nociceptin/orphanin FQ peptide receptor as a therapeutic target for obesity. Mini Reviews in Medicinal Chemistry. 8: 796-811. PMID 18673136 DOI: 10.2174/138955708784912139  0.96
2008 Lam DD, Przydzial MJ, Ridley SH, Yeo GS, Rochford JJ, O'Rahilly S, Heisler LK. Serotonin 5-HT2C receptor agonist promotes hypophagia via downstream activation of melanocortin 4 receptors. Endocrinology. 149: 1323-8. PMID 18039773 DOI: 10.1210/en.2007-1321  0.96
2007 Zhou L, Sutton GM, Rochford JJ, Semple RK, Lam DD, Oksanen LJ, Thornton-Jones ZD, Clifton PG, Yueh CY, Evans ML, McCrimmon RJ, Elmquist JK, Butler AA, Heisler LK. Serotonin 2C receptor agonists improve type 2 diabetes via melanocortin-4 receptor signaling pathways. Cell Metabolism. 6: 398-405. PMID 17983585 DOI: 10.1016/j.cmet.2007.10.008  0.96
2007 Heisler LK, Pronchuk N, Nonogaki K, Zhou L, Raber J, Tung L, Yeo GS, O'Rahilly S, Colmers WF, Elmquist JK, Tecott LH. Serotonin activates the hypothalamic-pituitary-adrenal axis via serotonin 2C receptor stimulation. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 27: 6956-64. PMID 17596444 DOI: 10.1523/JNEUROSCI.2584-06.2007  0.96
2007 Lam DD, Farooqi IS, Heisler LK. Melanocortin receptors as targets in the treatment of obesity. Current Topics in Medicinal Chemistry. 7: 1085-1097. PMID 17584129 DOI: 10.2174/156802607780906564  0.96
2007 Heisler LK, Zhou L, Bajwa P, Hsu J, Tecott LH. Serotonin 5-HT(2C) receptors regulate anxiety-like behavior. Genes, Brain, and Behavior. 6: 491-6. PMID 17451451 DOI: 10.1111/j.1601-183X.2007.00316.x  0.96
2007 Lam DD, Heisler LK. Serotonin and energy balance: molecular mechanisms and implications for type 2 diabetes. Expert Reviews in Molecular Medicine. 9: 1-24. PMID 17316471 DOI: 10.1017/S1462399407000245  0.96
2006 Heisler LK, Jobst EE, Sutton GM, Zhou L, Borok E, Thornton-Jones Z, Liu HY, Zigman JM, Balthasar N, Kishi T, Lee CE, Aschkenasi CJ, Zhang CY, Yu J, Boss O, et al. Serotonin reciprocally regulates melanocortin neurons to modulate food intake. Neuron. 51: 239-49. PMID 16846858 DOI: 10.1016/j.neuron.2006.06.004  0.96
2005 Zhou L, Williams T, Lachey JL, Kishi T, Cowley MA, Heisler LK. Serotonergic pathways converge upon central melanocortin systems to regulate energy balance. Peptides. 26: 1728-32. PMID 15993514 DOI: 10.1016/j.peptides.2004.12.028  0.96
2003 Heisler LK, Cowley MA, Kishi T, Tecott LH, Fan W, Low MJ, Smart JL, Rubinstein M, Tatro J, Zigman JM, Cone RD, Elmquist JK. Central serotonin and melanocortin pathways regulating energy homeostasis. Annals of the New York Academy of Sciences. 994: 169-74. PMID 12851313  0.96
2002 Heisler LK, Cowley MA, Tecott LH, Fan W, Low MJ, Smart JL, Rubinstein M, Tatro JB, Marcus JN, Holstege H, Lee CE, Cone RD, Elmquist JK. Activation of central melanocortin pathways by fenfluramine. Science (New York, N.Y.). 297: 609-11. PMID 12142539 DOI: 10.1126/science.1072327  0.96
2000 Heisler LK, Tecott LH. A paradoxical locomotor response in serotonin 5-HT(2C) receptor mutant mice. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 20: RC71. PMID 10751458  0.96
2000 Cruz J, Joiner TE, Johnson JG, Heisler LK, Spitzer RL, Pettit JW. Self-defeating personality disorder reconsidered. Journal of Personality Disorders. 14: 64-71. PMID 10746206  0.96
1999 Heisler LK, Tecott LH. Knockout Corner: Neurobehavioural consequences of a serotonin 5-HT(2C) receptor gene mutation. The International Journal of Neuropsychopharmacology / Official Scientific Journal of the Collegium Internationale Neuropsychopharmacologicum (Cinp). 2: 67-69. PMID 11281972 DOI: 10.1017/S1461145799001327  0.96
1999 Heisler LK, Kanarek RB, Homoleski B. Reduction of fat and protein intakes but not carbohydrate intake following acute and chronic fluoxetine in female rats. Pharmacology, Biochemistry, and Behavior. 63: 377-85. PMID 10418777 DOI: 10.1016/S0091-3057(99)00021-0  0.96
1999 Heisler LK, Tecott LH. Knockout Corner: Neurobehavioural consequences of a serotonin 5-HT2c receptor gene mutation International Journal of Neuropsychopharmacology. 2: 67-69.  0.96
1998 Heisler LK, Chu HM, Tecott LH. Epilepsy and obesity in serotonin 5-HT2C receptor mutant mice. Annals of the New York Academy of Sciences. 861: 74-8. PMID 9928241 DOI: 10.1111/j.1749-6632.1998.tb10175.x  0.96
1998 Heisler LK, Chu HM, Brennan TJ, Danao JA, Bajwa P, Parsons LH, Tecott LH. Elevated anxiety and antidepressant-like responses in serotonin 5-HT1A receptor mutant mice. Proceedings of the National Academy of Sciences of the United States of America. 95: 15049-54. PMID 9844013 DOI: 10.1073/pnas.95.25.15049  0.96
1997 Heisler LK, Kanarek RB, Gerstein A. Fluoxetine decreases fat and protein intakes but not carbohydrate intake in male rats. Pharmacology, Biochemistry, and Behavior. 58: 767-73. PMID 9329071 DOI: 10.1016/S0091-3057(97)00036-1  0.96
1997 Kanarek RB, Mathes WF, Heisler LK, Lima RP, Monfared LS. Prior exposure to palatable solutions enhances the effects of naltrexone on food intake in rats. Pharmacology, Biochemistry, and Behavior. 57: 377-81. PMID 9164597 DOI: 10.1016/S0091-3057(96)00337-1  0.96
1995 Heisler LK, Lyons MJ, Goethe JW. Self-defeating personality disorder. A cross-national study of clinical utility. The Journal of Nervous and Mental Disease. 183: 214-21; discussion 2. PMID 7714510  0.96
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