Frank Jirik - Publications

Affiliations: 
University of British Columbia, Vancouver, Vancouver, BC, Canada 
Area:
Neuroscience Biology

135 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2019 Martin GR, Henare K, Salazar C, Scheidl-Yee T, Eggen LJ, Tailor PP, Kim JH, Podstawka J, Fritzler MJ, Kelly MM, Yipp BG, Jirik FR. Expression of a constitutively active human mutant in hematopoietic cells produces an -dependent vasculopathy in mice. Life Science Alliance. 2. PMID 31221625 DOI: 10.26508/lsa.201800215  0.4
2016 Rana S, Elci SG, Mout R, Singla AK, Yazdani M, Bender M, Bajaj A, Saha K, Bunz UH, Jirik FR, Rotello VM. Ratiometric Array of Conjugated Polymers-Fluorescent Protein Provides a Robust Mammalian Cell Sensor. Journal of the American Chemical Society. PMID 26967961 DOI: 10.1021/Jacs.6B00067  1
2015 Parsons TE, Downey CM, Jirik FR, Hallgrimsson B, Jamniczky HA. Mind the gap: genetic manipulation of basicranial growth within synchondroses modulates calvarial and facial shape in mice through epigenetic interactions. Plos One. 10: e0118355. PMID 25692674 DOI: 10.1371/Journal.Pone.0118355  1
2015 Martin GR, Sharkey KA, Jirik FR. Orally administered indomethacin acutely reduces cellular prion protein in the small intestine and modestly increases survival of mice exposed to infectious prions. Scandinavian Journal of Gastroenterology. 50: 542-9. PMID 25599123 DOI: 10.3109/00365521.2014.1003400  1
2015 Singla AK, Downey CM, Bebb GD, Jirik FR. Characterization of a murine model of metastatic human nonsmall cell lung cancer and effect of CXCR4 inhibition on the growth of metastases Oncoscience. 2: 263-271. DOI: 10.18632/oncoscience.117  1
2014 Dadakhujaev S, Salazar-Arcila C, Netherton SJ, Chandhoke AS, Singla AK, Jirik FR, Bonni S. A novel role for the SUMO E3 ligase PIAS1 in cancer metastasis. Oncoscience. 1: 229-40. PMID 25594015 DOI: 10.18632/oncoscience.27  1
2014 Mickiewicz B, Villemaire ML, Sandercock LE, Jirik FR, Vogel HJ. Metabolic changes associated with selenium deficiency in mice. Biometals : An International Journal On the Role of Metal Ions in Biology, Biochemistry, and Medicine. 27: 1137-47. PMID 25012761 DOI: 10.1007/S10534-014-9774-Z  1
2014 Singla AK, Bondareva A, Jirik FR. Combined treatment with paclitaxel and suramin prevents the development of metastasis by inhibiting metastatic colonization of circulating tumor cells. Clinical & Experimental Metastasis. 31: 705-14. PMID 24965002 DOI: 10.1007/s10585-014-9661-6  1
2014 Thakur S, Singla AK, Chen J, Tran U, Yang Y, Salazar C, Magliocco A, Klimowicz A, Jirik F, Riabowol K. Reduced ING1 levels in breast cancer promotes metastasis. Oncotarget. 5: 4244-56. PMID 24962136 DOI: 10.18632/Oncotarget.1988  1
2014 Downey CM, Aghaei M, Schwendener RA, Jirik FR. DMXAA causes tumor site-specific vascular disruption in murine non-small cell lung cancer, and like the endogenous non-canonical cyclic dinucleotide STING agonist, 2′3′-cGAMP, induces M2 macrophage repolarization Plos One. 9. PMID 24940883 DOI: 10.1371/journal.pone.0099988  1
2014 Allan ER, Tailor P, Balce DR, Pirzadeh P, McKenna NT, Renaux B, Warren AL, Jirik FR, Yates RM. NADPH oxidase modifies patterns of MHC class II-restricted epitopic repertoires through redox control of antigen processing. Journal of Immunology (Baltimore, Md. : 1950). 192: 4989-5001. PMID 24778444 DOI: 10.4049/Jimmunol.1302896  1
2014 Luchman HA, Villemaire ML, Bismar TA, Carlson BA, Jirik FR. Prostate epithelium-specific deletion of the selenocysteine tRNA gene Trsp leads to early onset intraepithelial neoplasia. The American Journal of Pathology. 184: 871-7. PMID 24447801 DOI: 10.1016/j.ajpath.2013.11.025  1
2014 Bosma NA, Singla AK, Downey CM, Jirik FR. Selumetinib produces a central core of apoptosis in breast cancer bone metastases in mice Oncoscience. 1: 821-829. DOI: 10.18632/oncoscience.102  1
2014 Dang NHT, Singla AK, Mackay EM, Jirik FR, Weljie AM. Targeted cancer therapeutics: Biosynthetic and energetic pathways characterized by metabolomics and the interplay with key cancer regulatory factors Current Pharmaceutical Design. 20: 2637-2647.  1
2013 Shugg RP, Thomson A, Tanabe N, Kashishian A, Steiner BH, Puri KD, Pereverzev A, Lannutti BJ, Jirik FR, Dixon SJ, Sims SM. Effects of isoform-selective phosphatidylinositol 3-kinase inhibitors on osteoclasts: actions on cytoskeletal organization, survival, and resorption. The Journal of Biological Chemistry. 288: 35346-57. PMID 24133210 DOI: 10.1074/jbc.M113.507525  1
2013 Buie HR, Bosma NA, Downey CM, Jirik FR, Boyd SK. Micro-CT evaluation of bone defects: Applications to osteolytic bone metastases, bone cysts, and fracture Medical Engineering and Physics. 35: 1645-1650. PMID 23830560 DOI: 10.1016/j.medengphy.2013.05.016  1
2013 Graepel R, Leung G, Wang A, Villemaire M, Jirik FR, Sharkey KA, McDougall JJ, McKay DM. Murine autoimmune arthritis is exaggerated by infection with the rat tapeworm, Hymenolepis diminuta. International Journal For Parasitology. 43: 593-601. PMID 23583716 DOI: 10.1016/J.Ijpara.2013.02.006  1
2012 Rana S, Singla AK, Bajaj A, Elci SG, Miranda OR, Mout R, Yan B, Jirik FR, Rotello VM. Array-based sensing of metastatic cells and tissues using nanoparticle-fluorescent protein conjugates. Acs Nano. 6: 8233-40. PMID 22920837 DOI: 10.1021/Nn302917E  1
2012 Downey CM, Singla AK, Villemaire ML, Buie HR, Boyd SK, Jirik FR. Quantitative Ex-vivo micro-computed tomographic imaging of blood vessels and necrotic regions within tumors Plos One. 7. PMID 22848565 DOI: 10.1371/journal.pone.0041685  1
2012 Martin GR, Alvarez AL, Bashashati M, Keenan CM, Jirik FR, Sharkey KA. Endogenous cellular prion protein regulates contractility of the mouse ileum. Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society. 24: e412-24. PMID 22762267 DOI: 10.1111/J.1365-2982.2012.01970.X  1
2011 Helbing CC, Wagner MJ, Pettem K, Johnston J, Heimeier RA, Veldhoen N, Jirik FR, Shi YB, Browder LW. Modulation of thyroid hormone-dependent gene expression in Xenopus laevis by INhibitor of Growth (ING) proteins. Plos One. 6: e28658. PMID 22163049 DOI: 10.1371/Journal.Pone.0028658  1
2011 Martin GR, Keenan CM, Sharkey KA, Jirik FR. Endogenous prion protein attenuates experimentally induced colitis. The American Journal of Pathology. 179: 2290-301. PMID 21924230 DOI: 10.1016/J.Ajpath.2011.07.025  1
2011 Hahn JN, Falck VG, Jirik FR. Smad4 deficiency in T cells leads to the Th17-associated development of premalignant gastroduodenal lesions in mice. The Journal of Clinical Investigation. 121: 4030-42. PMID 21881210 DOI: 10.1172/JCI45114  1
2011 Weljie AM, Bondareva A, Zang P, Jirik FR. (1)H NMR metabolomics identification of markers of hypoxia-induced metabolic shifts in a breast cancer model system. Journal of Biomolecular Nmr. 49: 185-93. PMID 21373841 DOI: 10.1007/s10858-011-9486-4  1
2011 Duggan GE, Joan Miller B, Jirik FR, Vogel HJ. Metabolic profiling of vitamin C deficiency in Gulo-/- mice using proton NMR spectroscopy. Journal of Biomolecular Nmr. 49: 165-73. PMID 21360155 DOI: 10.1007/S10858-011-9485-5  1
2011 Pushie MJ, Pickering IJ, Martin GR, Tsutsui S, Jirik FR, George GN. Prion protein expression level alters regional copper, iron and zinc content in the mouse brain. Metallomics : Integrated Biometal Science. 3: 206-14. PMID 21264406 DOI: 10.1039/C0Mt00037J  1
2011 Weljie AM, Jirik FR. Hypoxia-induced metabolic shifts in cancer cells: moving beyond the Warburg effect. The International Journal of Biochemistry & Cell Biology. 43: 981-9. PMID 20797448 DOI: 10.1016/j.biocel.2010.08.009  1
2011 Downey CM, Jirik FR. Selenoproteins in skeletal development and disease: Lessons from trsp deletion in murine bone and cartilage progenitor cells Selenium: Its Molecular Biology and Role in Human Health. 573-587. DOI: 10.1007/978-1-4614-1025-6_45  1
2010 Johnson TA, Jirik FR, Fournier S. Exploring the roles of CD8(+) T lymphocytes in the pathogenesis of autoimmune demyelination. Seminars in Immunopathology. 32: 197-209. PMID 20237782 DOI: 10.1007/s00281-010-0199-7  1
2009 Downey CM, Horton CR, Carlson BA, Parsons TE, Hatfield DL, Hallgrímsson B, Jirik FR. Osteo-chondroprogenitor-specific deletion of the selenocysteine tRNA gene, Trsp, leads to chondronecrosis and abnormal skeletal development: a putative model for Kashin-Beck disease. Plos Genetics. 5: e1000616. PMID 19696890 DOI: 10.1371/Journal.Pgen.1000616  1
2009 Bondareva A, Downey CM, Ayres F, Liu W, Boyd SK, Hallgrimsson B, Jirik FR. The lysyl oxidase inhibitor, beta-aminopropionitrile, diminishes the metastatic colonization potential of circulating breast cancer cells. Plos One. 4: e5620. PMID 19440335 DOI: 10.1371/Journal.Pone.0005620  1
2009 Pushie MJ, Rauk A, Jirik FR, Vogel HJ. Can copper binding to the prion protein generate a misfolded form of the protein? Biometals. 22: 159-175. PMID 19140013 DOI: 10.1007/S10534-008-9196-X  1
2009 Khosravani H, Zhang Y, Tsutsui S, Hameed S, Altier C, Hamid J, Chen L, Villemaire M, Ali Z, Jirik FR, Zamponi GW. Prion protein attenuates excitotoxicity by inhibiting NMDA receptors (Journal of Cell Biology (2008) 181, 3 (551-565)) Journal of Cell Biology. 185: 1127. DOI: 10.1083/jcb.20071100220090522c  1
2008 Weljie AM, Newton J, Jirik FR, Vogel HJ. Evaluating low-intensity unknown signals in quantitative proton NMR mixture analysis Analytical Chemistry. 80: 8956-8965. PMID 19551928 DOI: 10.1021/Ac8012362  1
2008 Luchman HA, Benediktsson H, Villemaire ML, Peterson AC, Jirik FR. The pace of prostatic intraepithelial neoplasia development is determined by the timing of Pten tumor suppressor gene excision. Plos One. 3: e3940. PMID 19081794 DOI: 10.1371/journal.pone.0003940  1
2008 Tsutsui S, Hahn JN, Johnson TA, Ali Z, Jirik FR. Absence of the cellular prion protein exacerbates and prolongs neuroinflammation in experimental autoimmune encephalomyelitis. The American Journal of Pathology. 173: 1029-41. PMID 18815152 DOI: 10.2353/ajpath.2008.071062  1
2008 Heit B, Robbins SM, Downey CM, Guan Z, Colarusso P, Miller BJ, Jirik FR, Kubes P. PTEN functions to 'prioritize' chemotactic cues and prevent 'distraction' in migrating neutrophils. Nature Immunology. 9: 743-52. PMID 18536720 DOI: 10.1038/ni.1623  1
2008 Khosravani H, Zhang Y, Tsutsui S, Hameed S, Altier C, Hamid J, Chen L, Villemaire M, Ali Z, Jirik FR, Zamponi GW. Prion protein attenuates excitotoxicity by inhibiting NMDA receptors. The Journal of Cell Biology. 181: 551-65. PMID 18443219 DOI: 10.1083/Jcb.200711002  1
2008 Luchman HA, Friedman HC, Villemaire ML, Peterson AC, Jirik FR. Temporally controlled prostate epithelium-specific gene alterations. Genesis (New York, N.Y. : 2000). 46: 229-34. PMID 18395839 DOI: 10.1002/dvg.20386  1
2008 Johnson TA, Tsutsui S, Jirik FR. Antigen-induced Pten gene deletion in T cells exacerbates neuropathology in experimental autoimmune encephalomyelitis. The American Journal of Pathology. 172: 980-92. PMID 18349128 DOI: 10.2353/ajpath.2008.070892  1
2008 Sandercock LE, Hahn JN, Li L, Luchman HA, Giesbrecht JL, Peterson LA, Jirik FR. Mgmt deficiency alters the in vivo mutational spectrum of tissues exposed to the tobacco carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK). Carcinogenesis. 29: 866-74. PMID 18281247 DOI: 10.1093/carcin/bgn030  1
2008 Cummings KJ, Kalf D, Moore S, Miller BJ, Jirik FR, Wilson RJ. Superoxide dismutase-1 influences the timing and post-hypoxic stability of neonatal breathing. Advances in Experimental Medicine and Biology. 605: 133-8. PMID 18085260 DOI: 10.1007/978-0-387-73693-8_23  1
2007 Weljie AM, Dowlatabadi R, Miller BJ, Vogel HJ, Jirik FR. An inflammatory arthritis-associated metabolite biomarker pattern revealed by 1H NMR spectroscopy. Journal of Proteome Research. 6: 3456-64. PMID 17696462 DOI: 10.1021/pr070123j  1
2007 Ford-Hutchinson AF, Ali Z, Lines SE, Hallgrímsson B, Boyd SK, Jirik FR. Inactivation of Pten in osteo-chondroprogenitor cells leads to epiphyseal growth plate abnormalities and skeletal overgrowth. Journal of Bone and Mineral Research : the Official Journal of the American Society For Bone and Mineral Research. 22: 1245-59. PMID 17456009 DOI: 10.1359/Jbmr.070420  1
2007 Starnes LM, Downey CM, Boyd SK, Jirik FR. Increased bone mass in male and female mice following tamoxifen administration Genesis. 45: 229-235. PMID 17417806 DOI: 10.1002/dvg.20294  1
2007 Hallgrímsson B, Lieberman DE, Liu W, Ford-Hutchinson AF, Jirik FR. Epigenetic interactions and the structure of phenotypic variation in the cranium. Evolution & Development. 9: 76-91. PMID 17227368 DOI: 10.1111/J.1525-142X.2006.00139.X  1
2006 Hegan DC, Narayanan L, Jirik FR, Edelmann W, Liskay RM, Glazer PM. Differing patterns of genetic instability in mice deficient in the mismatch repair genes Pms2, Mlh1, Msh2, Msh3 and Msh6. Carcinogenesis. 27: 2402-8. PMID 16728433 DOI: 10.1093/carcin/bgl079  1
2006 Davies GA, Bryant AR, Reynolds JD, Jirik FR, Sharkey KA. Prion diseases and the gastrointestinal tract. Canadian Journal of Gastroenterology = Journal Canadien De Gastroenterologie. 20: 18-24. PMID 16432555 DOI: 10.1155/2006/184528  1
2006 Hallgrímsson B, Brown JJ, Ford-Hutchinson AF, Sheets HD, Zelditch ML, Jirik FR. The brachymorph mouse and the developmental-genetic basis for canalization and morphological integration. Evolution & Development. 8: 61-73. PMID 16409383 DOI: 10.1111/J.1525-142X.2006.05075.X  1
2005 Fortier M, Soni K, Laurin N, Wang SP, Mauriège P, Jirik FR, Mitchell GA. Human hormone-sensitive lipase (HSL): expression in white fat corrects the white adipose phenotype of HSL-deficient mice. Journal of Lipid Research. 46: 1860-7. PMID 15961788 DOI: 10.1194/Jlr.M500081-Jlr200  1
2005 Ford-Hutchinson AF, Ali Z, Seerattan RA, Cooper DM, Hallgrímsson B, Salo PT, Jirik FR. Degenerative knee joint disease in mice lacking 3'-phosphoadenosine 5'-phosphosulfate synthetase 2 (Papss2) activity: a putative model of human PAPSS2 deficiency-associated arthrosis. Osteoarthritis and Cartilage / Oars, Osteoarthritis Research Society. 13: 418-25. PMID 15882565 DOI: 10.1016/J.Joca.2004.12.011  1
2005 Choy JC, Cruz RP, Kerjner A, Geisbrecht J, Sawchuk T, Fraser SA, Hudig D, Bleackley RC, Jirik FR, McManus BM, Granville DJ. Granzyme B induces endothelial cell apoptosis and contributes to the development of transplant vascular disease. American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons. 5: 494-9. PMID 15707403 DOI: 10.1111/J.1600-6143.2004.00710.X  1
2004 Cummings KJ, Pendlebury JD, Jirik FR, Sherwood NM, Wilson RJ. A SIDS-like phenotype is associated with reduced respiratory chemoresponses in PACAP deficient neonatal mice. Advances in Experimental Medicine and Biology. 551: 77-83. PMID 15602947  1
2004 Sandercock LE, Kwok MC, Luchman HA, Mark SC, Giesbrecht JL, Samson LD, Jirik FR. Mutational-reporter transgenes rescued from mice lacking either Mgmt, or both Mgmt and Msh6 suggest that O6-alkylguanine-induced miscoding does not contribute to the spontaneous mutational spectrum. Oncogene. 23: 5931-40. PMID 15208683 DOI: 10.1038/sj.onc.1207791  1
2004 Moody JL, Jirik FR. Compound heterozygosity for Pten and SHIP augments T-dependent humoral immune responses and cytokine production by CD(4+) T cells. Immunology. 112: 404-12. PMID 15196208 DOI: 10.1111/j.1365-2567.2004.01901.x  1
2004 Moody JL, Xu L, Helgason CD, Jirik FR. Anemia, thrombocytopenia, leukocytosis, extramedullary hematopoiesis, and impaired progenitor function in Pten+/-SHIP-/- mice: a novel model of myelodysplasia. Blood. 103: 4503-10. PMID 15001465 DOI: 10.1182/Blood-2003-09-3262  1
2004 Monteith DP, Leung JD, Borowski AH, Co DO, Praznovszky T, Jirik FR, Hadlaczky G, Perez CF. Pronuclear microinjection of purified artificial chromosomes for generation of transgenic mice: pick-and-inject technique. Methods in Molecular Biology (Clifton, N.J.). 240: 227-42. PMID 14970413  1
2004 Storbeck CJ, Drmanic S, Daniel K, Waring JD, Jirik FR, Parry DJ, Ahmed N, Sabourin LA, Ikeda JE, Korneluk RG. Inhibition of myogenesis in transgenic mice expressing the human DMPK 3'-UTR. Human Molecular Genetics. 13: 589-600. PMID 14734627 DOI: 10.1093/Hmg/Ddh064  1
2004 Stapleton T, Luchman A, Johnston J, Browder L, Brenner S, Venkatesh B, Jirik FR. Compact intergenic regions of the pufferfish genome facilitate isolation of gene promoters: characterization of Fugu 3'-phosphoadenosine 5'-phosphosulfate synthase 2 (fPapss2) gene promoter function in transgenic Xenopus. Febs Letters. 556: 59-63. PMID 14706826 DOI: 10.1016/S0014-5793(03)01353-X  1
2003 Ford-Hutchinson AF, Cooper DM, Hallgrímsson B, Jirik FR. Imaging skeletal pathology in mutant mice by microcomputed tomography. The Journal of Rheumatology. 30: 2659-65. PMID 14719210  1
2003 Zhang T, Tan YH, Fu J, Lui D, Ning Y, Jirik FR, Brenner S, Venkatesh B. The regulation of retina specific expression of rhodopsin gene in vertebrates. Gene. 313: 189-200. PMID 12957390 DOI: 10.1016/S0378-1119(03)00680-2  1
2003 Moody JL, Pereira CG, Magil A, Fritzler MJ, Jirik FR. Loss of a single allele of SHIP exacerbates the immunopathology of Pten heterozygous mice. Genes and Immunity. 4: 60-6. PMID 12595903 DOI: 10.1038/sj.gene.6363903  1
2003 Hadjur S, Jirik FR. Increased sensitivity of Fancc-deficient hematopoietic cells to nitric oxide and evidence that this species mediates growth inhibition by cytokines. Blood. 101: 3877-84. PMID 12521994 DOI: 10.1182/blood-2002-10-3147  1
2002 Mark SC, Sandercock LE, Luchman HA, Baross A, Edelmann W, Jirik FR. Elevated mutant frequencies and predominance of G:C to A:T transition mutations in Msh6(-/-) small intestinal epithelium. Oncogene. 21: 7126-30. PMID 12370835 DOI: 10.1038/sj.onc.1205861  1
2002 Fox JA, Ung K, Tanlimco SG, Jirik FR. Disruption of a single Pten allele augments the chemotactic response of B lymphocytes to stromal cell-derived factor-1. Journal of Immunology (Baltimore, Md. : 1950). 169: 49-54. PMID 12077227 DOI: 10.4049/Jimmunol.169.1.49  1
2001 Gray SL, Cummings KJ, Jirik FR, Sherwood NM. Targeted disruption of the pituitary adenylate cyclase-activating polypeptide gene results in early postnatal death associated with dysfunction of lipid and carbohydrate metabolism Molecular Endocrinology. 15: 1739-1747. PMID 11579206 DOI: 10.1210/me.15.10.1739  1
2001 Yu WP, Pallen CJ, Tay A, Jirik FR, Brenner S, Tan YH, Venkatesh B. Conserved synteny between the Fugu and human PTEN locus and the evolutionary conservation of vertebrate PTEN function. Oncogene. 20: 5554-61. PMID 11571655 DOI: 10.1038/sj.onc.1204679  1
2001 Chang AH, O'Shaughnessy MV, Jirik FR. Hck SH3 domain-dependent abrogation of Nef-induced class 1 MHC down-regulation European Journal of Immunology. 31: 2382-2387. PMID 11500821 DOI: 10.1002/1521-4141(200108)31:8<2382::AID-IMMU2382>3.0.CO;2-K  1
2001 Hadjur S, Ung K, Wadsworth L, Dimmick J, Rajcan-Separovic E, Scott RW, Buchwald M, Jirik FR. Defective hematopoiesis and hepatic steatosis in mice with combined deficiencies of the genes encoding Fancc and Cu/Zn superoxide dismutase. Blood. 98: 1003-11. PMID 11493445 DOI: 10.1182/Blood.V98.4.1003  1
2001 Baross-Francis A, Makhani N, Liskay RM, Jirik FR. Elevated mutant frequencies and increased C : G-->T : A transitions in Mlh1-/- versus Pms2-/- murine small intestinal epithelial cells. Oncogene. 20: 619-25. PMID 11313994 DOI: 10.1038/Sj.Onc.1204138  1
2000 Campbell MR, Thang TY, Jirik FR, Andrew SE. Candidate mutator genes in mismatch repair-deficient thymic lymphomas: No evidence of mutations in the DNA polymerase δ gene Carcinogenesis. 21: 2281-2285. PMID 11133819  1
2000 Andrew SE, Xu XS, Baross-Francis A, Narayanan L, Milhausen K, Liskay RM, Jirik FR, Glazer PM. Mutagenesis in PMS2- and MSH2-deficient mice indicates differential protection from transversions and frameshifts. Carcinogenesis. 21: 1291-5. PMID 10874005 DOI: 10.1093/Carcin/21.7.1291  1
2000 Co DO, Borowski AH, Leung JD, van der Kaa J, Hengst S, Platenburg GJ, Pieper FR, Perez CF, Jirik FR, Drayer JI. Generation of transgenic mice and germline transmission of a mammalian artificial chromosome introduced into embryos by pronuclear microinjection. Chromosome Research : An International Journal On the Molecular, Supramolecular and Evolutionary Aspects of Chromosome Biology. 8: 183-91. PMID 10841045 DOI: 10.1023/A:1009206926548  1
2000 Baross-Francis A, Milhausen MK, Andrew SE, Jevon G, Jirik FR. Tumors arising in DNA mismatch repair-deficient mice show a wide variation in mutation frequency as assessed by a transgenic reporter gene. Carcinogenesis. 21: 1259-62. PMID 10837019 DOI: 10.1093/Carcin/21.6.1259  1
2000 Zvaritch E, Backx PH, Jirik F, Kimura Y, de Leon S, Schmidt AG, Hoit BD, Lester JW, Kranias EG, MacLennan DH. The transgenic expression of highly inhibitory monomeric forms of phospholamban in mouse heart impairs cardiac contractility. The Journal of Biological Chemistry. 275: 14985-91. PMID 10809743 DOI: 10.1074/Jbc.275.20.14985  1
2000 Babic I, Schallhorn A, Lindberg FP, Jirik FR. SHPS-1 induces aggregation of Ba/F3 pro-B cells via an interaction with CD47 Journal of Immunology. 164: 3652-3658. PMID 10725722  1
1999 Ong CJ, Ip S, Teh SJ, Wong C, Jirik FR, Grusby MJ, Teh HS. A role for T helper 2 cells in mediating skin fibrosis in tight-skin mice Cellular Immunology. 196: 60-68. PMID 10486156 DOI: 10.1006/cimm.1999.1537  1
1999 Andrew SE, Hsiao L, Milhausen K, Jirik FR. Comparison of selectable and plaque assay systems to detect menadione- and UV-induced lacI mutations in mammalian cells Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis. 427: 89-97. PMID 10393263 DOI: 10.1016/S0027-5107(99)00094-9  1
1999 Peacock JW, Jirik FR. TCR activation inhibits chemotaxis toward stromal cell-derived factor- 1: Evidence for reciprocal regulation between CXCR4 and the TCR Journal of Immunology. 162: 215-223. PMID 9886389  1
1999 Harder KW, Moller NPH, Peacock JW, Jirik FR. Protein-tyrosine phosphatase a regulates Src family kinases and alters cell-substratum adhesion Journal of Biological Chemistry. 273: 31890-31900. PMID 9822658 DOI: 10.1074/jbc.273.48.31890  1
1998 Chang AH, Hoxie JA, Cassol S, O'Shaughnessy M, Jirik F. Construction of single-chain antibodies that bind an overlapping epitope of HIV-1 Nef Febs Letters. 441: 307-312. PMID 9883905 DOI: 10.1016/S0014-5793(98)01569-5  1
1998 Ong C, Wong C, Roberts CR, Teh HS, Jirik FR. Anti-IL-4 treatment prevents dermal collagen deposition in the tight-skin mouse model of scleroderma European Journal of Immunology. 28: 2619-2629. PMID 9754550 DOI: 10.1002/(SICI)1521-4141(199809)28:09<2619::AID-IMMU2619>3.0.CO;2-M  1
1998 Baross-Francis A, Andrew SE, Penney JE, Jirik FR. Tumors of DNA mismatch repair-deficient hosts exhibit dramatic increases in genomic instability. Proceedings of the National Academy of Sciences of the United States of America. 95: 8739-43. PMID 9671748 DOI: 10.1073/Pnas.95.15.8739  1
1998 Helgason CD, Damen JE, Rosten P, Grewal R, Sorensen P, Chappel SM, Borowski A, Jirik F, Krystal G, Humphries RK. Targeted disruption of SHIP leads to hemopoietic perturbations, lung pathology, and a shortened life span Genes and Development. 12: 1610-1620. PMID 9620849  1
1998 Bapty BW, Dai LJ, Ritchie G, Jirik F, Canaff L, Hendy GN, Quamme GA. Extracellular Mg2+- and Ca2+-sensing in mouse distal convoluted tubule cells Kidney International. 53: 583-592. PMID 9507202 DOI: 10.1046/j.1523-1755.1998.00790.x  1
1998 Andrew SE, McKinnon M, Cheng BS, Francis A, Penney J, Reitmair AH, Mak TW, Jirik FR. Tissues of MSH2-deficient mice demonstrate hypermutability on exposure to a DNA methylating agent. Proceedings of the National Academy of Sciences of the United States of America. 95: 1126-30. PMID 9448296 DOI: 10.1073/pnas.95.3.1126  1
1998 Helaason OP, Damen JE, Rosten PM, Grewal R, Sorensen P, Chappel SM, Miller CL, Borowski A, Jirik F, Krystal G, Humphries RK. Targeted disruption of ship leads to hemopoietic perturbations, lung pathology, and a shortened lifespan Experimental Hematology. 26: 815.  1
1997 Ng DH, Jabali MD, Maiti A, Borodchak P, Harder KW, Brocker T, Malissen B, Jirik FR, Johnson P. CD45 and RPTPalpha display different protein tyrosine phosphatase activities in T lymphocytes. The Biochemical Journal. 327: 867-76. PMID 9581568  1
1997 Fritzell JA, Narayanan L, Baker SM, Bronner CE, Andrew SE, Prolla TA, Bradley A, Jirik FR, Liskay RM, Glazer PM. Role of DNA mismatch repair in the cytotoxicity of ionizing radiation. Cancer Research. 57: 5143-7. PMID 9371516  1
1997 Wang Q, Janzen N, Ramachandran C, Jirik F. Mechanism of inhibition of protein-tyrosine phosphatases by disodium aurothiomalate Biochemical Pharmacology. 54: 703-711. PMID 9310347 DOI: 10.1016/S0006-2952(97)00217-7  1
1997 Andrew SE, Reitmair AH, Fox J, Hsiao L, Francis A, McKinnon M, Mak TW, Jirik FR. Base transitions dominate the mutational spectrum of a transgenic reporter gene in MSH2 deficient mice Oncogene. 15: 123-129. PMID 9244348 DOI: 10.1038/Sj.Onc.1201180  1
1997 Bone H, Dechert U, Jirik F, Schrader JW, Welham MJ. SHP1 and SHP2 protein-tyrosine phosphatases associate with βc after interleukin-3-induced receptor tyrosine phosphorylation: Identification of potential binding sites and substrates Journal of Biological Chemistry. 272: 14470-14476. PMID 9162089 DOI: 10.1074/Jbc.272.22.14470  1
1997 Clarke LA, Russell CS, Pownall S, Warrington CL, Borowski A, Dimmick JE, Toone J, Jirik FR. Murine mucopolysaccharidosis type I: targeted disruption of the murine alpha-L-iduronidase gene. Human Molecular Genetics. 6: 503-11. PMID 9097952 DOI: 10.1093/hmg/6.4.503  1
1997 Liu L, Damen JE, Hughes MR, Babic I, Jirik FR, Krystal G. The Src homology 2 (SH2) domain of SH2-containing inositol phosphatase (SHIP) is essential for tyrosine phosphorylation of ship, its association with Shc, and its induction of apoptosis Journal of Biological Chemistry. 272: 8983-8988. PMID 9083021 DOI: 10.1074/jbc.272.14.8983  1
1997 Ng DHW, Jabali MD, Maiti A, Borodchak P, Harder KW, Brocker T, Malissen B, Jirik FR, Johnson P. CD45 and RPTPα display different protein tyrosine phosphatase activities in T lymphocytes Biochemical Journal. 327: 867-876.  1
1996 Babic I, Andrew SE, Jirik FR. MutS interaction with mismatch and alkylated base containing DNA molecules detected by optical biosensor Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis. 372: 87-96. PMID 9003535 DOI: 10.1016/S0027-5107(96)00170-4  1
1996 Andrew SE, Pownall S, Fox J, Hsiao L, Hambleton J, Penney JE, Kohler SW, Jirik FR. A novel lacI transgenic mutation-detection system and its application to establish baseline mutation frequencies in the scid mouse. Mutation Research. 357: 57-66. PMID 8876680 DOI: 10.1016/0027-5107(96)00080-2  1
1996 Goldberg YP, Kalchman MA, Metzler M, Nasir J, Zeisler J, Graham R, Koide HB, O'Kusky J, Sharp AH, Ross CA, Jirik F, Hayden MR. Absence of disease phenotype and intergenerational stability of the CAG repeat in transgenic mice expressing the human Huntington disease transcript Human Molecular Genetics. 5: 177-185. PMID 8824873 DOI: 10.1093/Hmg/5.2.177  1
1996 Berson JF, Long D, Doranz BJ, Rucker J, Jirik FR, Doms RW. A seven-transmembrane domain receptor involved in fusion and entry of T-cell-tropic human immunodeficiency virus type 1 strains. Journal of Virology. 70: 6288-95. PMID 8709256 DOI: 10.1128/Jvi.70.9.6288-6295.1996  1
1996 Melhado IG, Anderson LL, Duncan AMV, Jirik FR. The gene encoding protein-tyrosine phosphatase RPTPε (PTPRE) is assigned to human chromosome 10q26 Cytogenetics and Cell Genetics. 73: 168-170. PMID 8697801 DOI: 10.1159/000134332  1
1996 Adachi M, Fischer EH, Ihle J, Imai K, Jirik F, Neel B, Pawson T, Shen S, Thomas M, Ullrich A, Zhao Z. Mammalian SH2-containing protein tyrosine phosphatases. Cell. 85: 15. PMID 8620532  1
1995 Dechert U, Duncan AM, Bastien L, Duff C, Adam M, Jirik FR. Protein-tyrosine phosphatase SH-PTP2 (PTPN11) is localized to 12q24.1-24.3. Human Genetics. 96: 609-15. PMID 8530013 DOI: 10.1007/BF00197421  1
1995 Dechert U, Affolter M, Harder KW, Matthews J, Owen P, Clark-Lewis I, Thomas ML, Aebersold R, Jirik FR. Comparison of the specificity of bacterially expressed cytoplasmic protein-tyrosine phosphatases SHP and SH-PTP2 toward synthetic phosphopeptide substrates European Journal of Biochemistry. 231: 673-681. PMID 7649167 DOI: 10.1111/j.1432-1033.1995.0673d.x  1
1995 Harder KW, Saw J, Miki N, Jirik F. Coexisting Amplifications of the Chromosome 1p32 Genes (PTPRF and MYCL1) Encoding Protein Tyrosine Phosphatase LAR and L-myc in a Small Cell Lung Cancer Line Genomics. 27: 552-553. PMID 7558042 DOI: 10.1006/Geno.1995.1092  1
1995 Amankwa LN, Harder K, Jirik F, Aebersold R. High-sensitivity determination of tyrosine-phosphorylated peptides by on- line enzyme reactor and electrospray ionization mass spectrometry Protein Science. 4: 113-125. PMID 7539661 DOI: 10.1002/Pro.5560040114  1
1995 Ng DHW, Harder KW, Clark-Lewis I, Jirik F, Johnson P. Non-radioactive method to measure CD45 protein tyrosine phosphatase activity isolated directly from cells Journal of Immunological Methods. 179: 177-185. PMID 7533193 DOI: 10.1016/0022-1759(94)00281-Z  1
1994 Milich DR, Jones JE, Hughes JL, Maruyama T, Price J, Melhado I, Jirik F. Extrathymic expression of the intracellular hepatitis B core antigen results in T cell tolerance in transgenic mice. Journal of Immunology (Baltimore, Md. : 1950). 152: 455-66. PMID 8283030  1
1994 Tao W, Teh SJ, Melhado I, Jirik F, Korsmeyer SJ, Teh HS. The T cell receptor repertoire of CD4-8+ thymocytes is altered by overexpression of the BCL-2 protooncogene in the thymus Journal of Experimental Medicine. 179: 145-153. PMID 8270861 DOI: 10.1084/Jem.179.1.145  1
1994 Wang Q, Dechert U, Jirik F, Withers SG. Suicide inactivation of human prostatic acid phosphatase and a phosphotyrosine phosphatase Biochemical and Biophysical Research Communications. 200: 577-583. PMID 8166732 DOI: 10.1006/Bbrc.1994.1487  1
1994 Liu MS, Jirik FR, LeBoeuf RC, Henderson H, Castellani LW, Lusis AJ, Ma Y, Forsythe IJ, Zhang H, Kirk E, Brunzell JD, Hayden MR. Alteration of lipid profiles in plasma of transgenic mice expressing human lipoprotein lipase Journal of Biological Chemistry. 269: 11417-11424. PMID 8157673  1
1994 Harder KW, Owen P, Wong LKH, Aebersold R, Clark-Lewis I, Jirik FR. Characterization and kinetic analysis of the intracellular domain of human protein tyrosine phosphatase β (HPTPβ) using synthetic phosphopeptides Biochemical Journal. 298: 395-401. PMID 8135747  1
1994 Dechert U, Adam M, Harder KW, Clark-Lewis I, Jirik F. Characterization of Protein Tyrosine Phosphatase SH-PTP2: Study of Phosphopeptide Substrates and Possible Regulatory Role of SH2 Domains Journal of Biological Chemistry. 269: 5602-5611. PMID 8119896  1
1994 Welham MJ, Dechert U, Leslie KB, Jirik F, Schrader JW. Interleukin (IL)-3 and Granulocyte/Macrophage Colony-stimulating Factor, but Not IL-4, Induce Tyrosine Phosphorylation, Activation, and Association of SHPTP2 with Grb2 and Phosphatidylinositol 3′-Kinase Journal of Biological Chemistry. 269: 23764-23768. PMID 7522233  1
1993 Tighe H, Chen PP, Tucker R, Kipps TJ, Roudier J, Jirik FR, Carson DA. Function of B cells expressing a human immunoglobulin M rheumatoid factor autoantibody in transgenic mice Journal of Experimental Medicine. 177: 109-118. PMID 8418195 DOI: 10.1084/Jem.177.1.109  1
1993 Federsppiel B, Melhado IG, Duncan AMV, Delaney A, Schappert K, Clark- Lewis I, Jirik FR. Molecular cloning of the cDNA and chromosomal localization of the gene for a putative seven-transmembrane segment (7-TMS) receptor isolated from human spleen Genomics. 16: 707-712. PMID 8325644 DOI: 10.1006/geno.1993.1251  1
1993 Crawford TJ, Melhado IG, Jirik FR. Expression of versican mRNA is developmentally regulated in the brain of the embryonic chick and the developing rat Developmental Brain Research. 76: 264-267. PMID 8149594 DOI: 10.1016/0165-3806(93)90216-W  1
1993 Peppel K, Poltorak A, Melhado I, Jirik F, Beutler B. Expression of a TNF inhibitorin transgenic mice Journal of Immunology. 151: 5699-5703. PMID 7693816  1
1993 Charest DL, Mordret G, Harder KW, Jirik F, Pelech SL. Molecular Cloning, Expression, and Characterization of the Human Mitogen-Activated Protein Kinase p44erk1 Molecular and Cellular Biology. 13: 4679-4690. PMID 7687743 DOI: 10.1128/Mcb.13.8.4679  1
1992 Jirik FR, Anderson LL, Duncan AMV. The human protein-tyrosine phosphatase PTPα/LRP gene (PTPA) is assigned to chromosome 20p13 Cytogenetic and Genome Research. 60: 117-118. PMID 1611910 DOI: 10.1159/000133317  1
1992 Harder KW, Anderson LL, Jirik FR, Duncan AMV. The gene for receptor-like protein tyrosine phosphatase (PTPRB) is assigned to chromosome 12q15→q21 Cytogenetic and Genome Research. 61: 269-270. PMID 1486802 DOI: 10.1159/000133419  1
1992 Jirik FR, Harder KW, Melhado IG, Anderson LL, Duncan AMV. The gene for leukocyte antigen-related tyrosine phosphatase (LAR) is localized to human chromosome 1p32, a region frequently deleted in tumors of neuroectodermal origin Cytogenetic and Genome Research. 61: 266-268. PMID 1486801 DOI: 10.1159/000133418  1
1990 Jirik FR, Janzen NM, Melhado IG, Harder KW. Cloning and chromosomal assignment of a widely expressed human receptor-like protein-tyrosine phosphatase Febs Letters. 273: 239-242. PMID 2172030 DOI: 10.1016/0014-5793(90)81094-5  1
1989 Jirik FR, Podor TJ, Hirano T, Kishimoto T, Loskutoff DJ, Carson DA, Lotz M. Bacterial lipopolysaccharide and inflammatory mediators augment IL-6 secretion by human endothelial cells Journal of Immunology. 142: 144-147. PMID 2783321  1
1989 PODOR TJ, JIRIK FR, LOSKUTOFF DJ, CARSON DA, LOTZ M. Human Endothelial Cells Produce IL‐6: Lack of Responses to Exogenous IL‐6 Annals of the New York Academy of Sciences. 557: 374-387. PMID 2660697 DOI: 10.1111/J.1749-6632.1989.Tb24030.X  1
1989 LOTZ M, ZURAW BL, CARSON DA, JIRIK FR. Hepatocytes Produce Interleukin‐6 Annals of the New York Academy of Sciences. 557: 509-511. DOI: 10.1111/J.1749-6632.1989.Tb24048.X  1
1988 Dycaico MJ, Grant SG, Felts K, Nichols WS, Geller SA, Hager JH, Pollard AJ, Kohler SW, Short HP, Jirik FR. Neonatal hepatitis induced by alpha 1-antitrypsin: a transgenic mouse model. Science (New York, N.Y.). 242: 1409-12. PMID 3264419 DOI: 10.1126/Science.3264419  1
1988 Lotz M, Jirik F, Kabouridis P, Tsoukas C, Hirano T, Kishimoto T, Carson DA. B cell stimulating factor 2/interleukin 6 is a costimulant for human thymocytes and T lymphocytes Journal of Experimental Medicine. 167: 1253-1258. PMID 3127525 DOI: 10.1084/Jem.167.3.1253  1
1987 Jirik FR, Burstein SA, Treger L, Sorge JA. Transfection of a factor-dependent cell line with the murine interleukin-3 (IL-3) cDNA results in autonomous growth and tumorigenesis Leukemia Research. 11: 1127-1134. PMID 3501044 DOI: 10.1016/0145-2126(87)90167-6  1
1987 Carson DA, Chen PP, Kipps TJ, Radoux V, Jirik F, Goldfien RD, Fox RI, Silverman GJ, Fong S. Molecular basis for the cross-reactive idiotypes on human anti-IgG autoantibodies (rheumatoid factors) Ciba Foundation Symposium. 129: 123-134. PMID 3315499 DOI: 10.1002/9780470513484.ch9  1
1987 Carson DA, Chen PP, Kipps TJ, Radoux V, Jirik FR, Goldfien RD, Fox RI, Silverman GJ, Fong S. Idiotypic and genetic studies of human rheumatoid factors Arthritis and Rheumatism. 30: 1321-1325. PMID 3124859 DOI: 10.1002/Art.1780301201  1
1987 Chen PP, Robbins DL, Jirik FR, Kipps TJ, Carson DA. Isolation and characterization of a light chain variable region gene for human rheumatoid factors. The Journal of Experimental Medicine. 166: 1900-5. PMID 3119763 DOI: 10.1084/Jem.166.6.1900  1
1987 Carson DA, Chen PP, Fox RI, Kipps TJ, Jirik F, Goldfien RD, Silverman G, Radoux V, Fong S. Rheumatoid factor and immune networks Annual Review of Immunology. 5: 109-126. PMID 2439101 DOI: 10.1146/Annurev.Iy.05.040187.000545  1
1986 Fong S, Chen PP, Fox RI, Goldfien RD, Silverman GJ, Radoux V, Jirik F, Vaughan JH, Carson DA. Rheumatoid factors in human autoimmune disease: their origin, development and function Pathology and Immunopathology Research. 5: 305-316. PMID 3110754 DOI: 10.1159/000157024  1
1986 Jirik FR, Sorge J, Fong S, Heitzmann JG, Curd JG, Chen PP, Goldfien R, Carson DA. Cloning and sequence determination of a human rheumatoid factor light-chain gene Proceedings of the National Academy of Sciences of the United States of America. 83: 2195-2199. PMID 3083417 DOI: 10.1073/Pnas.83.7.2195  1
1985 Chen PP, Goñi F, Fong S, Jirik F, Vaughan JH, Frangione B, Carson DA. The majority of human monoclonal IgM rheumatoid factors express a "primary structure-dependent" cross-reactive idiotype. Journal of Immunology (Baltimore, Md. : 1950). 134: 3281-5. PMID 3920316  1
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