N W. Milgram - Publications

Affiliations: 
University of Toronto, Toronto, ON, Canada 
Area:
Neuroscience Biology

155 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2017 Snigdha S, Yassa MA, deRivera C, Milgram NW, Cotman CW. Pattern separation and goal-directed behavior in the aged canine. Learning & Memory (Cold Spring Harbor, N.Y.). 24: 123-131. PMID 28202716 DOI: 10.1101/lm.043422.116  0.4
2016 Zanghi BM, Gardner C, Araujo J, Milgram NW. Diurnal changes in core body temperature, day/night locomotor activity patterns, and actigraphy-generated behavioral sleep in aged canines with varying levels of cognitive dysfunction Neurobiology of Sleep and Circadian Rhythms. 1: 8-18. DOI: 10.1016/j.nbscr.2016.07.001  0.96
2015 Snigdha S, de Rivera C, Milgram NW, Cotman CW. Effect of mitochondrial cofactors and antioxidants supplementation on cognition in the aged canine. Neurobiology of Aging. PMID 26481404 DOI: 10.1016/j.neurobiolaging.2015.09.015  0.4
2015 Lazarowski L, Foster ML, Gruen ME, Sherman BL, Fish RE, Milgram NW, Dorman DC. Olfactory discrimination and generalization of ammonium nitrate and structurally related odorants in Labrador retrievers. Animal Cognition. 18: 1255-65. PMID 26160342 DOI: 10.1007/s10071-015-0894-9  0.96
2015 Zanghi BM, Araujo J, Milgram NW. Cognitive domains in the dog: independence of working memory from object learning, selective attention, and motor learning. Animal Cognition. 18: 789-800. PMID 25677729 DOI: 10.1007/s10071-015-0847-3  0.96
2015 Landsberg GM, Mougeot I, Kelly S, Milgram NW. Assessment of noise-induced fear and anxiety in dogs: Modification by a novel fish hydrolysate supplemented diet Journal of Veterinary Behavior: Clinical Applications and Research. 10: 391-398. DOI: 10.1016/j.jveb.2015.05.007  0.96
2015 Milgram NW, Landsberg G, Merrick D, Underwood MY. A novel mechanism for cognitive enhancement in aged dogs with the use of a calcium-buffering protein Journal of Veterinary Behavior: Clinical Applications and Research. 10: 217-222. DOI: 10.1016/j.jveb.2015.02.003  0.96
2014 Snigdha S, de Rivera C, Milgram NW, Cotman CW. Exercise enhances memory consolidation in the aging brain. Frontiers in Aging Neuroscience. 6: 3. PMID 24550824 DOI: 10.3389/fnagi.2014.00003  0.96
2014 Lazarowski L, Foster ML, Gruen ME, Sherman BL, Case BC, Fish RE, Milgram NW, Dorman DC. Acquisition of a visual discrimination and reversal learning task by Labrador retrievers. Animal Cognition. 17: 787-92. PMID 24277162 DOI: 10.1007/s10071-013-0712-1  0.96
2013 Zanghi BM, Cupp CJ, Pan Y, Tissot-Favre DG, Milgram NW, Nagy TR, Dobson H. Noninvasive measurements of body composition and body water via quantitative magnetic resonance, deuterium water, and dual-energy x-ray absorptiometry in awake and sedated dogs. American Journal of Veterinary Research. 74: 733-43. PMID 23627386 DOI: 10.2460/ajvr.74.5.733  0.96
2013 Zanghi BM, Cupp CJ, Pan Y, Tissot-Favre DG, Milgram NW, Nagy TR, Dobson H. Noninvasive measurements of body composition and body water via quantitative magnetic resonance, deuterium water, and dual-energy x-ray absorptiometry in cats. American Journal of Veterinary Research. 74: 721-32. PMID 23627385 DOI: 10.2460/ajvr.74.5.721  0.96
2013 Snigdha S, Milgram NW, Willis SL, Albert M, Weintraub S, Fortin NJ, Cotman CW. A preclinical cognitive test battery to parallel the National Institute of Health Toolbox in humans: bridging the translational gap. Neurobiology of Aging. 34: 1891-901. PMID 23434040 DOI: 10.1016/j.neurobiolaging.2013.01.018  0.96
2013 Pan Y, Araujo JA, Burrows J, de Rivera C, Gore A, Bhatnagar S, Milgram NW. Cognitive enhancement in middle-aged and old cats with dietary supplementation with a nutrient blend containing fish oil, B vitamins, antioxidants and arginine. The British Journal of Nutrition. 110: 40-9. PMID 23211671 DOI: 10.1017/S0007114512004771  0.96
2013 Araujo JA, de Rivera C, Landsberg GM, Adams PE, Milgram NW. Development and validation of a novel laboratory model of sound-induced fear and anxiety in Beagle dogs Journal of Veterinary Behavior: Clinical Applications and Research. 8: 204-212. DOI: 10.1016/j.jveb.2012.10.008  0.96
2013 Zanghi BM, Kerr W, Gierer J, de Rivera C, Araujo JA, Milgram NW. Characterizing behavioral sleep using actigraphy in adult dogs of various ages fed once or twice daily Journal of Veterinary Behavior: Clinical Applications and Research. 8: 195-203. DOI: 10.1016/j.jveb.2012.10.007  0.96
2012 Zicker SC, Jewell DE, Yamka RM, Milgram NW. Evaluation of cognitive learning, memory, psychomotor, immunologic, and retinal functions in healthy puppies fed foods fortified with docosahexaenoic acid-rich fish oil from 8 to 52 weeks of age. Journal of the American Veterinary Medical Association. 241: 583-94. PMID 22916855 DOI: 10.2460/javma.241.5.583  0.96
2012 Snigdha S, Christie LA, De Rivera C, Araujo JA, Milgram NW, Cotman CW. Age and distraction are determinants of performance on a novel visual search task in aged Beagle dogs. Age (Dordrecht, Netherlands). 34: 67-73. PMID 21336566 DOI: 10.1007/s11357-011-9219-3  0.96
2012 Zanghi BM, Kerr W, de Rivera C, Araujo JA, Milgram NW. Effect of age and feeding schedule on diurnal rest/activity rhythms in dogs Journal of Veterinary Behavior: Clinical Applications and Research. 7: 339-347. DOI: 10.1016/j.jveb.2012.01.004  0.96
2011 Araujo JA, Greig NH, Ingram DK, Sandin J, de Rivera C, Milgram NW. Cholinesterase inhibitors improve both memory and complex learning in aged beagle dogs. Journal of Alzheimer's Disease : Jad. 26: 143-55. PMID 21593569 DOI: 10.3233/JAD-2011-110005  0.96
2011 Collison KS, Zaidi MZ, Saleh SM, Inglis A, Mondreal R, Makhoul NJ, Bakheet R, Burrows J, Milgram NW, Al-Mohanna FA. Effect of trans-fat, fructose and monosodium glutamate feeding on feline weight gain, adiposity, insulin sensitivity, adipokine and lipid profile. The British Journal of Nutrition. 106: 218-26. PMID 21429276 DOI: 10.1017/S000711451000588X  0.96
2011 Araujo JA, Nobrega JN, Raymond R, Milgram NW. Aged dogs demonstrate both increased sensitivity to scopolamine impairment and decreased muscarinic receptor density. Pharmacology, Biochemistry, and Behavior. 98: 203-9. PMID 21238475 DOI: 10.1016/j.pbb.2011.01.005  0.96
2010 Trepanier CH, Milgram NW. Neuroinflammation in Alzheimer's disease: are NSAIDs and selective COX-2 inhibitors the next line of therapy? Journal of Alzheimer's Disease : Jad. 21: 1089-99. PMID 21504126 DOI: 10.3233/JAD-2010-090667  0.96
2010 Pop V, Head E, Hill MA, Gillen D, Berchtold NC, Muggenburg BA, Milgram NW, Murphy MP, Cotman CW. Synergistic effects of long-term antioxidant diet and behavioral enrichment on beta-amyloid load and non-amyloidogenic processing in aged canines. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 30: 9831-9. PMID 20660265 DOI: 10.1523/JNEUROSCI.6194-09.2010  0.96
2010 Creed MC, Milgram NW. Amyloid-modifying therapies for Alzheimer's disease: therapeutic progress and its implications. Age (Dordrecht, Netherlands). 32: 365-84. PMID 20640545 DOI: 10.1007/s11357-010-9142-z  0.96
2010 Pan Y, Larson B, Araujo JA, Lau W, de Rivera C, Santana R, Gore A, Milgram NW. Dietary supplementation with medium-chain TAG has long-lasting cognition-enhancing effects in aged dogs. The British Journal of Nutrition. 103: 1746-54. PMID 20141643 DOI: 10.1017/S0007114510000097  0.96
2010 Collison KS, Makhoul NJ, Inglis A, Al-Johi M, Zaidi MZ, Maqbool Z, Saleh SM, Bakheet R, Mondreal R, Al-Rabiah R, Shoukri M, Milgram NW, Al-Mohanna FA. Dietary trans-fat combined with monosodium glutamate induces dyslipidemia and impairs spatial memory. Physiology & Behavior. 99: 334-42. PMID 19945473 DOI: 10.1016/j.physbeh.2009.11.010  0.96
2010 Araujo JA, de Rivera C, Ethier JL, Landsberg GM, Denenberg S, Arnold S, Milgram NW. ANXITANE® tablets reduce fear of human beings in a laboratory model of anxiety-related behavior Journal of Veterinary Behavior: Clinical Applications and Research. 5: 268-275. DOI: 10.1016/j.jveb.2010.02.003  0.96
2009 Christie LA, Opii WO, Head E, Araujo JA, de Rivera C, Milgram NW, Cotman CW. Short-term supplementation with acetyl-L-carnitine and lipoic acid alters plasma protein carbonyl levels but does not improve cognition in aged beagles. Experimental Gerontology. 44: 752-9. PMID 19735717 DOI: 10.1016/j.exger.2009.08.012  0.96
2009 Kogan CS, Boutet I, Cornish K, Graham GE, Berry-Kravis E, Drouin A, Milgram NW. A comparative neuropsychological test battery differentiates cognitive signatures of Fragile X and Down syndrome. Journal of Intellectual Disability Research : Jidr. 53: 125-42. PMID 19054268 DOI: 10.1111/j.1365-2788.2008.01135.x  0.96
2008 Poma R, Chambers H, da Costa RC, Konyer NB, Nykamp S, Dobson H, Milgram NW. MRI measurement of the canine auditory pathways and relationship with brainstem auditory evoked responses. Veterinary and Comparative Orthopaedics and Traumatology : V.C.O.T. 21: 238-42. PMID 18536850  0.96
2008 Araujo JA, Landsberg GM, Milgram NW, Miolo A. Improvement of short-term memory performance in aged beagles by a nutraceutical supplement containing phosphatidylserine, Ginkgo biloba, vitamin E, and pyridoxine. The Canadian Veterinary Journal. La Revue VéTéRinaire Canadienne. 49: 379-85. PMID 18481547  0.96
2008 Siwak-Tapp CT, Head E, Muggenburg BA, Milgram NW, Cotman CW. Region specific neuron loss in the aged canine hippocampus is reduced by enrichment. Neurobiology of Aging. 29: 39-50. PMID 17092609 DOI: 10.1016/j.neurobiolaging.2006.09.018  0.96
2008 Opii WO, Joshi G, Head E, Milgram NW, Muggenburg BA, Klein JB, Pierce WM, Cotman CW, Butterfield DA. Proteomic identification of brain proteins in the canine model of human aging following a long-term treatment with antioxidants and a program of behavioral enrichment: relevance to Alzheimer's disease. Neurobiology of Aging. 29: 51-70. PMID 17055614 DOI: 10.1016/j.neurobiolaging.2006.09.012  0.96
2007 Chow TW, Pollock BG, Milgram NW. Potential cognitive enhancing and disease modification effects of SSRIs for Alzheimer's disease. Neuropsychiatric Disease and Treatment. 3: 627-36. PMID 19300592  0.96
2007 Boutet I, Milgram NW, Freedman M. Cognitive decline and human (Homo sapiens) aging: an investigation using a comparative neuropsychological approach. Journal of Comparative Psychology (Washington, D.C. : 1983). 121: 270-81. PMID 17696653 DOI: 10.1037/0735-7036.121.3.270  0.96
2007 Milgram NW, Araujo JA, Hagen TM, Treadwell BV, Ames BN. Acetyl-L-carnitine and alpha-lipoic acid supplementation of aged beagle dogs improves learning in two landmark discrimination tests. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 21: 3756-62. PMID 17622567 DOI: 10.1096/fj.07-8531com  0.96
2007 Siwak-Tapp CT, Head E, Muggenburg BA, Milgram NW, Cotman CW. Neurogenesis decreases with age in the canine hippocampus and correlates with cognitive function. Neurobiology of Learning and Memory. 88: 249-59. PMID 17587610 DOI: 10.1016/j.nlm.2007.05.001  0.96
2007 Nippak PM, Mendelson J, Muggenburg B, Milgram NW. Enhanced spatial ability in aged dogs following dietary and behavioural enrichment. Neurobiology of Learning and Memory. 87: 610-23. PMID 17303448 DOI: 10.1016/j.nlm.2007.01.001  0.96
2007 Boutet I, Kogan C, Milgram NW. A comparative neuropsychological approach to cognitive assessment in clinical populations Psychological Tests and Testing Research Trends. 151-172.  0.96
2006 Milgram NW, Siwak-Tapp CT, Araujo J, Head E. Neuroprotective effects of cognitive enrichment. Ageing Research Reviews. 5: 354-69. PMID 16949888 DOI: 10.1016/j.arr.2006.04.004  0.96
2006 Studzinski CM, Christie LA, Araujo JA, Burnham WM, Head E, Cotman CW, Milgram NW. Visuospatial function in the beagle dog: an early marker of cognitive decline in a model of human aging and dementia. Neurobiology of Learning and Memory. 86: 197-204. PMID 16616528 DOI: 10.1016/j.nlm.2006.02.005  0.96
2006 Head E, Barrett EG, Murphy MP, Das P, Nistor M, Sarsoza F, Glabe CC, Kayed R, Milton S, Vasilevko V, Milgram NW, Agadjanyan MG, Cribbs DH, Cotman CW. Immunization with fibrillar Abeta(1-42) in young and aged canines: Antibody generation and characteristics, and effects on CSF and brain Abeta. Vaccine. 24: 2824-34. PMID 16460841 DOI: 10.1016/j.vaccine.2005.12.058  0.96
2006 Nippak PM, Ikeda-Douglas C, Milgram NW. Extensive spatial training does not negate age differences in response latency. Brain Research. 1070: 171-88. PMID 16460702 DOI: 10.1016/j.brainres.2005.11.026  0.96
2006 Tapp PD, Head K, Head E, Milgram NW, Muggenburg BA, Su MY. Application of an automated voxel-based morphometry technique to assess regional gray and white matter brain atrophy in a canine model of aging. Neuroimage. 29: 234-44. PMID 16275022 DOI: 10.1016/j.neuroimage.2005.07.043  0.96
2005 Araujo JA, Studzinski CM, Head E, Cotman CW, Milgram NW. Assessment of nutritional interventions for modification of age-associated cognitive decline using a canine model of human aging. Age (Dordrecht, Netherlands). 27: 27-37. PMID 23598601 DOI: 10.1007/s11357-005-4001-z  0.96
2005 Roudebush P, Zicker SC, Cotman CW, Milgram NW, Muggenburg BA, Head E. Nutritional management of brain aging in dogs. Journal of the American Veterinary Medical Association. 227: 722-8. PMID 16178393 DOI: 10.2460/javma.2005.227.722  0.96
2005 Studzinski CM, Araujo JA, Milgram NW. The canine model of human cognitive aging and dementia: pharmacological validity of the model for assessment of human cognitive-enhancing drugs. Progress in Neuro-Psychopharmacology & Biological Psychiatry. 29: 489-98. PMID 15795058 DOI: 10.1016/j.pnpbp.2004.12.014  0.96
2005 Chan JW, Araujo JA, Zicker SC, Pun TW, Milgram NW. Effect of feeding patterns on performance of a visuospatial memory task in the beagle dog: a novel cognitive-based protocol for assessing satiety. Progress in Neuro-Psychopharmacology & Biological Psychiatry. 29: 481-8. PMID 15795057 DOI: 10.1016/j.pnpbp.2004.12.013  0.96
2005 Siwak CT, Tapp PD, Head E, Zicker SC, Murphey HL, Muggenburg BA, Ikeda-Douglas CJ, Cotman CW, Milgram NW. Chronic antioxidant and mitochondrial cofactor administration improves discrimination learning in aged but not young dogs. Progress in Neuro-Psychopharmacology & Biological Psychiatry. 29: 461-9. PMID 15795055 DOI: 10.1016/j.pnpbp.2004.12.011  0.96
2005 Nelson L, Johnson JK, Freedman M, Lott I, Groot J, Chang M, Milgram NW, Head E. Learning and memory as a function of age in Down syndrome: a study using animal-based tasks. Progress in Neuro-Psychopharmacology & Biological Psychiatry. 29: 443-53. PMID 15795053 DOI: 10.1016/j.pnpbp.2004.12.009  0.96
2005 Boutet I, Ryan M, Kulaga V, McShane C, Christie LA, Freedman M, Milgram NW. Age-associated cognitive deficits in humans and dogs: a comparative neuropsychological approach. Progress in Neuro-Psychopharmacology & Biological Psychiatry. 29: 433-41. PMID 15795052 DOI: 10.1016/j.pnpbp.2004.12.015  0.96
2005 Araujo JA, Studzinski CM, Milgram NW. Further evidence for the cholinergic hypothesis of aging and dementia from the canine model of aging. Progress in Neuro-Psychopharmacology & Biological Psychiatry. 29: 411-22. PMID 15795050 DOI: 10.1016/j.pnpbp.2004.12.008  0.96
2005 Tapp PD, Chu Y, Araujo JA, Chiou JY, Head E, Milgram NW, Su MY. Effects of scopolamine challenge on regional cerebral blood volume. A pharmacological model to validate the use of contrast enhanced magnetic resonance imaging to assess cerebral blood volume in a canine model of aging. Progress in Neuro-Psychopharmacology & Biological Psychiatry. 29: 399-406. PMID 15795048 DOI: 10.1016/j.pnpbp.2004.12.006  0.96
2005 de Rivera C, Boutet I, Zicker SC, Milgram NW. A novel method for assessing contrast sensitivity in the beagle dog is sensitive to age and an antioxidant enriched food. Progress in Neuro-Psychopharmacology & Biological Psychiatry. 29: 379-87. PMID 15795046 DOI: 10.1016/j.pnpbp.2004.12.004  0.96
2005 Nippak PM, Milgram NW. An investigation of the relationship between response latency across several cognitive tasks in the beagle dog. Progress in Neuro-Psychopharmacology & Biological Psychiatry. 29: 371-7. PMID 15795045 DOI: 10.1016/j.pnpbp.2004.12.003  0.96
2005 Christie LA, Studzinski CM, Araujo JA, Leung CS, Ikeda-Douglas CJ, Head E, Cotman CW, Milgram NW. A comparison of egocentric and allocentric age-dependent spatial learning in the beagle dog. Progress in Neuro-Psychopharmacology & Biological Psychiatry. 29: 361-9. PMID 15795044 DOI: 10.1016/j.pnpbp.2004.12.002  0.96
2005 Ikeda-Douglas CJ, de Rivera C, Milgram NW. Pharmaceutical and other commercial uses of the dog model. Progress in Neuro-Psychopharmacology & Biological Psychiatry. 29: 355-60. PMID 15795043 DOI: 10.1016/j.pnpbp.2004.12.001  0.96
2005 Niimura M, Moussa R, Bissoon N, Ikeda-Douglas C, Milgram NW, Gurd JW. Changes in phosphorylation of the NMDA receptor in the rat hippocampus induced by status epilepticus. Journal of Neurochemistry. 92: 1377-85. PMID 15748156 DOI: 10.1111/j.1471-4159.2005.02977.x  0.96
2005 Milgram NW, Head E, Zicker SC, Ikeda-Douglas CJ, Murphey H, Muggenburg B, Siwak C, Tapp D, Cotman CW. Learning ability in aged beagle dogs is preserved by behavioral enrichment and dietary fortification: a two-year longitudinal study. Neurobiology of Aging. 26: 77-90. PMID 15585348 DOI: 10.1016/j.neurobiolaging.2004.02.014  0.96
2005 Head E, Cotman CW, Zicker SC, Milgram NW. The use of dietary antioxidants and mitochondrial co-factors to promote successful aging Current Topics in Nutraceutical Research. 3: 85-94.  0.96
2004 Araujo JA, Studzinski CM, Larson BT, Milgram NW. Comparison of the cognitive palatability assessment protocol and the two-pan test for use in assessing palatability of two similar foods in dogs. American Journal of Veterinary Research. 65: 1490-6. PMID 15566086 DOI: 10.2460/ajvr.2004.65.1490  0.96
2004 Tapp PD, Siwak CT, Gao FQ, Chiou JY, Black SE, Head E, Muggenburg BA, Cotman CW, Milgram NW, Su MY. Frontal lobe volume, function, and beta-amyloid pathology in a canine model of aging. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 24: 8205-13. PMID 15385603 DOI: 10.1523/JNEUROSCI.1339-04.2004  0.96
2004 Araujo JA, Milgram NW. A novel cognitive palatability assessment protocol for dogs. Journal of Animal Science. 82: 2200-6. PMID 15309970  0.96
2004 Tapp PD, Siwak CT, Head E, Cotman CW, Murphey H, Muggenburg BA, Ikeda-Douglas C, Milgram NW. Concept abstraction in the aging dog: development of a protocol using successive discrimination and size concept tasks. Behavioural Brain Research. 153: 199-210. PMID 15219721 DOI: 10.1016/j.bbr.2003.12.003  0.96
2004 Ikeda-Douglas CJ, Zicker SC, Estrada J, Jewell DE, Milgram NW. Prior experience, antioxidants, and mitochondrial cofactors improve cognitive function in aged beagles. Veterinary Therapeutics : Research in Applied Veterinary Medicine. 5: 5-16. PMID 15150725  0.96
2004 Milgram NW, Head E, Zicker SC, Ikeda-Douglas C, Murphey H, Muggenberg BA, Siwak CT, Tapp PD, Lowry SR, Cotman CW. Long-term treatment with antioxidants and a program of behavioral enrichment reduces age-dependent impairment in discrimination and reversal learning in beagle dogs. Experimental Gerontology. 39: 753-65. PMID 15130670 DOI: 10.1016/j.exger.2004.01.007  0.96
2004 Araujo JA, Chan AD, Winka LL, Seymour PA, Milgram NW. Dose-specific effects of scopolamine on canine cognition: impairment of visuospatial memory, but not visuospatial discrimination. Psychopharmacology. 175: 92-8. PMID 15029470 DOI: 10.1007/s00213-004-1777-y  0.96
2003 Milgram NW. Cognitive experience and its effect on age-dependent cognitive decline in beagle dogs. Neurochemical Research. 28: 1677-82. PMID 14584821 DOI: 10.1023/A:1026009005108  0.96
2003 Nippak PM, Chan AD, Campbell Z, Muggenburg B, Head E, Ikeda-Douglas CJ, Murphey H, Cotman CW, Milgram NW. Response latency in Canis familiaris: mental ability or mental strategy? Behavioral Neuroscience. 117: 1066-75. PMID 14570555 DOI: 10.1037/0735-7044.117.5.1066  0.96
2003 Siwak CT, Tapp PD, Milgram NW. Adrafinil disrupts performance on a delayed nonmatching-to-position task in aged beagle dogs. Pharmacology, Biochemistry, and Behavior. 76: 161-8. PMID 13679229 DOI: 10.1016/S0091-3057(03)00211-9  0.96
2003 Siwak CT, Tapp PD, Zicker SC, Murphey HL, Muggenburg BA, Head E, Cotman CW, Milgram NW. Locomotor activity rhythms in dogs vary with age and cognitive status. Behavioral Neuroscience. 117: 813-24. PMID 12931965 DOI: 10.1037/0735-7044.117.4.813  0.96
2003 Tapp PD, Siwak CT, Estrada J, Holowachuk D, Milgram NW. Effects of age on measures of complex working memory span in the beagle dog (Canis familiaris) using two versions of a spatial list learning paradigm. Learning & Memory (Cold Spring Harbor, N.Y.). 10: 148-60. PMID 12663753 DOI: 10.1101/lm.56503  0.96
2003 Tapp PD, Siwak CT, Estrada J, Head E, Muggenburg BA, Cotman CW, Milgram NW. Size and reversal learning in the beagle dog as a measure of executive function and inhibitory control in aging. Learning & Memory (Cold Spring Harbor, N.Y.). 10: 64-73. PMID 12551965 DOI: 10.1101/lm.54403  0.96
2003 Head E, Milgram NW, Cotman CW. Neuropathology in ageing dogs | Neuropathologische Veränderungen bei alternden Hunden Praktische Tierarzt. 84: 192-195.  0.96
2002 Milgram NW, Head E, Muggenburg B, Holowachuk D, Murphey H, Estrada J, Ikeda-Douglas CJ, Zicker SC, Cotman CW. Landmark discrimination learning in the dog: effects of age, an antioxidant fortified food, and cognitive strategy. Neuroscience and Biobehavioral Reviews. 26: 679-95. PMID 12479842 DOI: 10.1016/S0149-7634(02)00039-8  0.96
2002 Cotman CW, Head E, Muggenburg BA, Zicker S, Milgram NW. Brain aging in the canine: a diet enriched in antioxidants reduces cognitive dysfunction. Neurobiology of Aging. 23: 809-18. PMID 12392784 DOI: 10.1016/S0197-4580(02)00073-8  0.96
2002 Milgram NW, Zicker SC, Head E, Muggenburg BA, Murphey H, Ikeda-Douglas CJ, Cotman CW. Dietary enrichment counteracts age-associated cognitive dysfunction in canines. Neurobiology of Aging. 23: 737-45. PMID 12392778 DOI: 10.1016/S0197-4580(02)00020-9  0.96
2002 Head E, Liu J, Hagen TM, Muggenburg BA, Milgram NW, Ames BN, Cotman CW. Oxidative damage increases with age in a canine model of human brain aging. Journal of Neurochemistry. 82: 375-81. PMID 12124438 DOI: 10.1046/j.1471-4159.2002.00969.x  0.96
2002 Chan AD, Nippak PM, Murphey H, Ikeda-Douglas CJ, Muggenburg B, Head E, Cotman CW, Milgram NW. Visuospatial impairments in aged canines (Canis familiaris): the role of cognitive-behavioral flexibility. Behavioral Neuroscience. 116: 443-54. PMID 12049325 DOI: 10.1037/0735-7044.116.3.443  0.96
2002 Siwak CT, Murphey HL, Muggenburg BA, Milgram NW. Age-dependent decline in locomotor activity in dogs is environment specific. Physiology & Behavior. 75: 65-70. PMID 11890954 DOI: 10.1016/S0031-9384(01)00632-1  0.96
2001 Siwak CT, Tapp PD, Milgram NW. Effect of age and level of cognitive function on spontaneous and exploratory behaviors in the beagle dog. Learning & Memory (Cold Spring Harbor, N.Y.). 8: 317-25. PMID 11773431 DOI: 10.1101/lm.41701  0.96
2001 Moussa RC, Ikeda-Douglas CJ, Thakur V, Milgram NW, Gurd JW. Seizure activity results in increased tyrosine phosphorylation of the N-methyl-D-aspartate receptor in the hippocampus. Brain Research. Molecular Brain Research. 95: 36-47. PMID 11687275 DOI: 10.1016/S0169-328X(01)00231-5  0.96
2001 Fecteau J, Milgram NW. The ability to smell remains intact, but does not recover, after olfactory bulb lesions. The International Journal of Neuroscience. 108: 11-20. PMID 11328698  0.96
2000 Siwak CT, Callahan H, Milgram NW. Adrafinil: effects on behavior and cognition in aged canines. Progress in Neuro-Psychopharmacology & Biological Psychiatry. 24: 709-26. PMID 11191710 DOI: 10.1016/S0278-5846(00)00103-2  0.96
2000 Callahan H, Ikeda-Douglas C, Head E, Cotman CW, Milgram NW. Development of a protocol for studying object recognition memory in the dog. Progress in Neuro-Psychopharmacology & Biological Psychiatry. 24: 693-707. PMID 11191709 DOI: 10.1016/S0278-5846(00)00102-0  0.96
2000 Adams B, Chan A, Callahan H, Milgram NW. The canine as a model of human cognitive aging: recent developments. Progress in Neuro-Psychopharmacology & Biological Psychiatry. 24: 675-92. PMID 11191708 DOI: 10.1016/S0278-5846(00)00101-9  0.96
2000 Head E, Cotman CW, Milgram NW. Canine cognition, aging and neuropathology. Introduction. Progress in Neuro-Psychopharmacology & Biological Psychiatry. 24: 671-3. PMID 11191707 DOI: 10.1016/S0278-5846(00)00100-7  0.96
2000 Siwak CT, Gruet P, Woehrlé F, Muggenburg BA, Murphey HL, Milgram NW. Comparison of the effects of adrafinil, propentofylline, and nicergoline on behavior in aged dogs. American Journal of Veterinary Research. 61: 1410-4. PMID 11108188  0.96
2000 Milgram NW, Siwak CT, Gruet P, Atkinson P, Woehrlé F, Callahan H. Oral administration of adrafinil improves discrimination learning in aged beagle dogs. Pharmacology, Biochemistry, and Behavior. 66: 301-5. PMID 10880682 DOI: 10.1016/S0091-3057(00)00175-1  0.96
2000 Siwak CT, Gruet P, Woehrlé F, Schneider M, Muggenburg BA, Murphey HL, Callahan H, Milgram NW. Behavioral activating effects of adrafinil in aged canines. Pharmacology, Biochemistry, and Behavior. 66: 293-300. PMID 10880681 DOI: 10.1016/S0091-3057(00)00188-X  0.96
2000 Head E, McCleary R, Hahn FF, Milgram NW, Cotman CW. Region-specific age at onset of beta-amyloid in dogs. Neurobiology of Aging. 21: 89-96. PMID 10794853 DOI: 10.1016/S0197-4580(00)00093-2  0.96
2000 Torp R, Head E, Milgram NW, Hahn F, Ottersen OP, Cotman CW. Ultrastructural evidence of fibrillar beta-amyloid associated with neuronal membranes in behaviorally characterized aged dog brains. Neuroscience. 96: 495-506. PMID 10717430 DOI: 10.1016/S0306-4522(99)00568-0  0.96
2000 Adams B, Chan A, Callahan H, Siwak C, Tapp D, Ikeda-Douglas C, Atkinson P, Head E, Cotman CW, Milgram NW. Use of a delayed non-matching to position task to model age-dependent cognitive decline in the dog. Behavioural Brain Research. 108: 47-56. PMID 10680756 DOI: 10.1016/S0166-4328(99)00132-1  0.96
1999 Morgan HD, Watchus JA, Milgram NW, Fleming AS. The long lasting effects of electrical simulation of the medial preoptic area and medial amygdala on maternal behavior in female rats. Behavioural Brain Research. 99: 61-73. PMID 10512573 DOI: 10.1016/S0166-4328(98)00070-9  0.96
1999 Rick JT, Milgram NW. Instability of dentate gyrus field potentials in awake and anesthetized rats. Hippocampus. 9: 333-9. PMID 10401647 DOI: 10.1002/(SICI)1098-1063(1999)9:3<333::AID-HIPO12>3.0.CO;2-2  0.96
1999 Milgram NW, Adams B, Callahan H, Head E, Mackay B, Thirlwell C, Cotman CW. Landmark discrimination learning in the dog. Learning & Memory (Cold Spring Harbor, N.Y.). 6: 54-61. PMID 10355524  0.96
1999 Milgram NW, Callahan H, Siwak C. Adrafinil: A novel vigilance promoting agent Cns Drug Reviews. 5: 193-212.  0.96
1998 Head E, Callahan H, Muggenburg BA, Cotman CW, Milgram NW. Visual-discrimination learning ability and beta-amyloid accumulation in the dog. Neurobiology of Aging. 19: 415-25. PMID 9880044 DOI: 10.1016/S0197-4580(98)00084-0  0.96
1998 Ikeda-Douglas CJ, Head E, Holsinger RM, Tremblay L, Racine R, Milgram NW. Selective loss of early suppression in the dentate gyrus precedes kainic acid induced electrographic seizures. Epilepsy Research. 31: 143-52. PMID 9714506 DOI: 10.1016/S0920-1211(98)00028-X  0.96
1998 Michalakis M, Holsinger D, Ikeda-Douglas C, Cammisuli S, Ferbinteanu J, DeSouza C, DeSouza S, Fecteau J, Racine RJ, Milgram NW. Development of spontaneous seizures over extended electrical kindling. I. Electrographic, behavioral, and transfer kindling correlates. Brain Research. 793: 197-211. PMID 9630628 DOI: 10.1016/S0006-8993(98)00155-3  0.96
1997 Cammisuli S, Murphy MP, Ikeda-Douglas CJ, Balkissoon V, Holsinger RM, Head E, Michael M, Racine RJ, Milgram NW. Effects of extended electrical kindling on exploratory behavior and spatial learning. Behavioural Brain Research. 89: 179-90. PMID 9475625 DOI: 10.1016/S0166-4328(97)00059-4  0.96
1997 Satou T, Cummings BJ, Head E, Nielson KA, Hahn FF, Milgram NW, Velazquez P, Cribbs DH, Tenner AJ, Cotman CW. The progression of beta-amyloid deposition in the frontal cortex of the aged canine. Brain Research. 774: 35-43. PMID 9452189 DOI: 10.1016/S0006-8993(97)81684-8  0.96
1997 Head E, Callahan H, Cummings BJ, Cotman CW, Ruehl WW, Muggenberg BA, Milgram NW. Open field activity and human interaction as a function of age and breed in dogs. Physiology & Behavior. 62: 963-71. PMID 9333188 DOI: 10.1016/S0031-9384(97)00198-4  0.96
1997 Ferbinteanu J, Milgram NW. Origin of the lateral perforant path. Hippocampus. 7: 350-1. PMID 9228531 DOI: 10.1002/(SICI)1098-1063(1997)7:3<350::AID-HIPO9>3.0.CO;2-O  0.96
1996 Cummings BJ, Satou T, Head E, Milgram NW, Cole GM, Savage MJ, Podlisny MB, Selkoe DJ, Siman R, Greenberg BD, Cotman CW. Diffuse plaques contain C-terminal A beta 42 and not A beta 40: evidence from cats and dogs. Neurobiology of Aging. 17: 653-9. PMID 8832640 DOI: 10.1016/0197-4580(96)00062-0  0.96
1996 Rick JT, Milgram NW. Frequency dependence of long-term potentiation and depression in the dentate gyrus of the freely moving rat. Hippocampus. 6: 118-24. PMID 8797013 DOI: 10.1002/(SICI)1098-1063(1996)6:2<118::AID-HIPO3>3.0.CO;2-L  0.96
1996 Head E, Hartley J, Kameka AM, Mehta R, Ivy GO, Ruehl WW, Milgram NW. The effects of L-deprenyl on spatial short term memory in young and aged dogs. Progress in Neuro-Psychopharmacology & Biological Psychiatry. 20: 515-30. PMID 8771606 DOI: 10.1016/0278-5846(96)00014-0  0.96
1996 Cummings BJ, Head E, Ruehl W, Milgram NW, Cotman CW. The canine as an animal model of human aging and dementia. Neurobiology of Aging. 17: 259-68. PMID 8744407 DOI: 10.1016/0197-4580(95)02060-8  0.96
1996 Rick JT, Murphy MP, Ivy GO, Milgram NW. Short intertrial intervals impair water maze performance in old Fischer 344 rats. The Journals of Gerontology. Series a, Biological Sciences and Medical Sciences. 51: B253-60. PMID 8680989 DOI: 10.1093/gerona/51A.4.B253  0.96
1996 Cummings BJ, Head E, Afagh AJ, Milgram NW, Cotman CW. Beta-amyloid accumulation correlates with cognitive dysfunction in the aged canine. Neurobiology of Learning and Memory. 66: 11-23. PMID 8661247 DOI: 10.1006/nlme.1996.0039  0.96
1995 Racine RJ, Chapman CA, Trepel C, Teskey GC, Milgram NW. Post-activation potentiation in the neocortex. IV. Multiple sessions required for induction of long-term potentiation in the chronic preparation. Brain Research. 702: 87-93. PMID 8846100 DOI: 10.1016/0006-8993(95)01025-0  0.96
1995 Racine RJ, Chapman CA, Teskey GC, Milgram NW. Post-activation potentiation in the neocortex. III. Kindling-induced potentiation in the chronic preparation. Brain Research. 702: 77-86. PMID 8846099 DOI: 10.1016/0006-8993(95)01024-9  0.96
1995 Ruehl WW, Bruyette DS, DePaoli A, Cotman CW, Head E, Milgram NW, Cummings BJ. Canine cognitive dysfunction as a model for human age-related cognitive decline, dementia and Alzheimer's disease: clinical presentation, cognitive testing, pathology and response to 1-deprenyl therapy. Progress in Brain Research. 106: 217-25. PMID 8584657  0.96
1995 Head E, Mehta R, Hartley J, Kameka M, Cummings BJ, Cotman CW, Ruehl WW, Milgram NW. Spatial learning and memory as a function of age in the dog. Behavioral Neuroscience. 109: 851-8. PMID 8554710  0.96
1995 Milgram NW, Michael M, Cammisuli S, Head E, Ferbinteanu J, Reid C, Murphy MP, Racine R. Development of spontaneous seizures over extended electrical kindling. II. Persistence of dentate inhibitory suppression. Brain Research. 670: 112-20. PMID 7719710 DOI: 10.1016/0006-8993(94)01277-O  0.96
1995 Milgram NW, Ivy GO, Murphy MP, Head E, Wu PH, Ruehl WW, Yu PH, Durden DA, Davis BA, Boulton AA. Effects of chronic oral administration of L-deprenyl in the dog. Pharmacology, Biochemistry, and Behavior. 51: 421-8. PMID 7667363 DOI: 10.1016/0091-3057(94)00417-H  0.96
1995 Murphy MP, Rick JT, Milgram NW, Ivy GO. A simple and rapid test of sensorimotor function in the aged rat. Neurobiology of Learning and Memory. 64: 181-6. PMID 7582826 DOI: 10.1006/nlme.1995.1057  0.96
1994 Milgram NW, Head E, Weiner E, Thomas E. Cognitive functions and aging in the dog: acquisition of nonspatial visual tasks. Behavioral Neuroscience. 108: 57-68. PMID 8192851 DOI: 10.1037//0735-7044.108.1.57  0.96
1994 Carrillo MC, Ivy GO, Milgram NW, Head E, Wu P, Kitani K. (-)Deprenyl increases activities of superoxide dismutase (SOD) in striatum of dog brain. Life Sciences. 54: 1483-9. PMID 8190023 DOI: 10.1016/0024-3205(94)90015-9  0.96
1994 Racine RJ, Teskey GC, Wilson D, Seidlitz E, Milgram NW. Post-activation potentiation and depression in the neocortex of the rat: II. Chronic preparations. Brain Research. 637: 83-96. PMID 8180823 DOI: 10.1016/0006-8993(94)91220-3  0.96
1994 Racine RJ, Wilson D, Teskey GC, Milgram NW. Post-activation potentiation in the neocortex: I. Acute preparations. Brain Research. 637: 73-82. PMID 8180822 DOI: 10.1016/0006-8993(94)91219-X  0.96
1994 Ivy GO, Rick JT, Murphy MP, Head E, Reid C, Milgram NW. Effects of L-deprenyl on manifestations of aging in the rat and dog. Annals of the New York Academy of Sciences. 717: 45-59. PMID 8030851 DOI: 10.1111/j.1749-6632.1994.tb12072.x  0.96
1993 Murphy MP, Wu PH, Milgram NW, Ivy GO. Monoamine oxidase inhibition by L-deprenyl depends on both sex and route of administration in the rat. Neurochemical Research. 18: 1299-304. PMID 8272194 DOI: 10.1007/BF00975051  0.96
1993 Milgram NW, Ivy GO, Head E, Murphy MP, Wu PH, Ruehl WW, Yu PH, Durden DA, Davis BA, Paterson IA. The effect of L-deprenyl on behavior, cognitive function, and biogenic amines in the dog. Neurochemical Research. 18: 1211-9. PMID 8272186 DOI: 10.1007/BF00975038  0.96
1992 Head E, Milgram NW. Changes in spontaneous behavior in the dog following oral administration of L-deprenyl. Pharmacology, Biochemistry, and Behavior. 43: 749-57. PMID 1448469 DOI: 10.1016/0091-3057(92)90404-4  0.96
1991 Bramham CR, Milgram NW, Srebro B. Activation of AP5-sensitive NMDA Receptors is Not Required to Induce LTP of Synaptic Transmission in the Lateral Perforant Path. The European Journal of Neuroscience. 3: 1300-1308. PMID 12106227  0.96
1991 Milgram NW, Yearwood T, Khurgel M, Ivy GO, Racine R. Changes in inhibitory processes in the hippocampus following recurrent seizures induced by systemic administration of kainic acid Brain Research. 551: 236-246. PMID 1913154 DOI: 10.1016/0006-8993(91)90938-R  0.96
1991 Bramham CR, Milgram NW, Srebro B. Delta opioid receptor activation is required to induce LTP of synaptic transmission in the lateral perforant path in vivo. Brain Research. 567: 42-50. PMID 1667745 DOI: 10.1016/0006-8993(91)91433-2  0.96
1990 García-Cabrera I, Milgram NW, Berge OG. Electroencephalographic and behavioural correlates of seizures development in rats in response to hyperbaric exposure Epilepsy Research. 7: 65-71. PMID 2292248 DOI: 10.1016/0920-1211(90)90055-Z  0.96
1990 Milgram NW, Racine RJ, Nellis P, Mendonca A, Ivy GO. Maintenance on L-deprenyl prolongs life in aged male rats. Life Sciences. 47: 415-20. PMID 2118586 DOI: 10.1016/0024-3205(90)90299-7  0.96
1989 Burnham WM, Racine RJ, Milgram NW, Albright PS. Effects of phenytoin, carbamazepine, and clonazepam on cortex- and amygdala-evoked potentials in partially kindled rats. Experimental Neurology. 106: 150-5. PMID 2806456 DOI: 10.1016/0014-4886(89)90088-5  0.96
1989 Petit TL, LeBoutillier JC, Markus EJ, Milgram NW. Synaptic structural plasticity following repetitive activation in the rat hippocampus. Experimental Neurology. 105: 72-9. PMID 2744129 DOI: 10.1016/0014-4886(89)90173-8  0.96
1988 Milgram NW, Isen DA, Mandel D, Palantzas H, Pepkowski MJ. Deficits in spontaneous behavior and cognitive function following systemic administration of kainic acid Neurotoxicology. 9: 611-624. PMID 3244444  0.96
1987 Segal M, Greenberger V, Milgram NW. Chapter 28 A functional analysis of connections between grafted septal neurons and host hippocampus Progress in Brain Research. 71: 349-357. PMID 3588953 DOI: 10.1016/S0079-6123(08)61836-1  0.96
1985 Milgram NW, Green I, Liberman M, Riexinger K, Petit TL. Establishment of status epilepticus by limbic system stimulation in previously unstimulated rats. Experimental Neurology. 88: 253-64. PMID 3987856 DOI: 10.1016/0014-4886(85)90189-X  0.96
1985 Campbell KA, Milgram NW. Mechanisms underlying the plasticity of hippocampal stimulation-induced reward Behavioral Neuroscience. 99: 209-219. PMID 3843708 DOI: 10.1037//0735-7044.99.2.209  0.96
1984 Campbell KA, Bank B, Milgram NW. Epileptogenic effects of electrolytic lesions in the hippocampus: Role of iron deposition Experimental Neurology. 86: 506-514. PMID 6499991 DOI: 10.1016/0014-4886(84)90085-2  0.96
1984 Caudarella M, Campbell KA, Milgram NW. Hippocampal stimulation limits performance but does not retard acquisition of food-reinforced learning. Physiology & Behavior. 32: 895-8. PMID 6494297 DOI: 10.1016/0031-9384(84)90214-2  0.96
1983 Racine RJ, Milgram NW, Hafner S. Long-term potentiation phenomena in the rat limbic forebrain. Brain Research. 260: 217-31. PMID 6299454 DOI: 10.1016/0006-8993(83)90676-5  0.96
1983 Racine RJ, Milgram NW. Short-term potentiation phenomena in the rat limbic forebrain. Brain Research. 260: 201-16. PMID 6299453 DOI: 10.1016/0006-8993(83)90675-3  0.96
1982 Caudarella M, Campbell KA, Milgram NW. Differential effects of diazepam (valium) on brain stimulation reward sites. Pharmacology, Biochemistry, and Behavior. 16: 17-21. PMID 7058208 DOI: 10.1016/0091-3057(82)90006-5  0.96
1982 Milgram NW. On the generality of the anhedonia hypothesis Behavioral and Brain Sciences. 5: 69. DOI: 10.1017/S0140525X00010530  0.96
1980 Campbell KA, Milgram NW. Potentiating hippocampal stimulation facilitates acquisition of lever-pressing for stimulation but not food Physiology and Behavior. 24: 1115-1118. PMID 7413791 DOI: 10.1016/0031-9384(80)90056-6  0.96
1979 Milgram NW. On the inadequacy of a homeostatic model: Where do we go from here? Behavioral and Brain Sciences. 2: 111-112. DOI: 10.1017/S0140525X00061227  0.96
1978 Campbell KA, Milgram NW, Christoff JK. Plasticity in the reinforcing consequences of hippocampal stimulation Brain Research. 159: 458-462. PMID 728815 DOI: 10.1016/0006-8993(78)90558-9  0.96
1978 Milgram NW, Smith HL, Chong SM. Rapid development of motor seizures in rats barpressing for electrical stimulation of the preoptic area Physiological Psychology. 6: 57-60. DOI: 10.3758/BF03326692  0.96
1977 Milgram NW, Server AC, Campbell KA. Effect of food and water deprivation on hippocampal self-stimulation and poststimulation feeding Physiological Psychology. 5: 43-48. DOI: 10.3758/BF03335296  0.96
1975 Milgram NW, Grant DP, Stockman SM. Situational control over electrically induced ingestive behavior: A comparison of hippocampal and hypothalamic feeding Physiological Psychology. 3: 337-339. DOI: 10.3758/BF03326836  0.96
1974 Biederman GB, Milgram NW, Heighington GA, Stockman SM, O'Neill W. Memory of conditioned food aversion follows a U-shape function in rats. The Quarterly Journal of Experimental Psychology. 26: 610-5. PMID 4438560 DOI: 10.1080/14640747408400453  0.96
1974 Milgram NW, Krames L, Thompson R. Influence of drinking history on food-deprived drinking in the rat Journal of Comparative and Physiological Psychology. 87: 126-133. PMID 4413862 DOI: 10.1037/h0036587  0.96
1973 Krames L, Milgram NW, Christie DP. Predatory aggression: Differential suppression of killing and feeding Behavioral Biology. 9: 641-647. PMID 4796851 DOI: 10.1016/S0091-6773(73)80059-8  0.96
1973 Grant DP, Milgram NW. Plasticity of normal feeding: situational and individual factors Canad.J.Psychol.. 27: 305-316. PMID 4778714  0.96
1971 Milgram NW, Devor M, Server AC. Spontaneous changes in behaviors induced by electrical stimulation of the lateral hypothalamus in rats. Journal of Comparative and Physiological Psychology. 75: 491-9. PMID 5091229 DOI: 10.1037/h0030926  0.96
1970 Wise RA, Devor MG, Milgram NW, Hoebel BG. Physiological control of hypothalamically elicited feeding and drinking. Journal of Comparative and Physiological Psychology. 73: 226-32. PMID 5493262 DOI: 10.1037/h0030209  0.96
1969 Milgram NW. Effect of hippocampal stimulation on feeding in the rat Physiology and Behavior. 4: 665-670.  0.96
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