Denise Belsham - Publications

Affiliations: 
University of Toronto, Toronto, ON, Canada 
Area:
Animal Physiology Biology, Neuroscience Biology

108 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any innacuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2016 Loganathan N, Belsham DD. Nutrient sensing mechanisms in hypothalamic cell models: Neuropeptide regulation and neuroinflammation in male- and female-derived cell lines. American Journal of Physiology. Regulatory, Integrative and Comparative Physiology. ajpregu.00168.2016. PMID 27306829 DOI: 10.1152/ajpregu.00168.2016  1
2016 Treen AK, Luo V, Belsham DD. Phoenixin activates immortalized GnRH and kisspeptin neurons through the novel receptor GPR173. Molecular Endocrinology (Baltimore, Md.). me20161039. PMID 27268078 DOI: 10.1210/me.2016-1039  1
2016 Tran DQ, Tse EK, Kim MH, Belsham DD. Diet-induced cellular neuroinflammation in the hypothalamus: Mechanistic insights from investigation of neurons and microglia. Molecular and Cellular Endocrinology. PMID 27208620 DOI: 10.1016/j.mce.2016.05.015  1
2016 Wellhauser L, Chalmers JA, Belsham DD. Nitric Oxide Exerts Basal and Insulin-Dependent Anorexigenic Actions in POMC Hypothalamic Neurons. Molecular Endocrinology (Baltimore, Md.). 30: 402-16. PMID 26930171 DOI: 10.1210/me.2015-1275  1
2016 Oosterman JE, Belsham DD. Glucose Alters Per2 Rhythmicity Independent of AMPK, Whereas AMPK Inhibitor Compound C Causes Profound Repression of Clock Genes and AgRP in mHypoE-37 Hypothalamic Neurons. Plos One. 11: e0146969. PMID 26784927 DOI: 10.1371/journal.pone.0146969  1
2016 Treen AK, Luo V, Chalmers JA, Dalvi PS, Tran D, Ye W, Kim GL, Friedman Z, Belsham DD. Divergent regulation of ER and Kiss genes by 17β-estradiol in hypothalamic ARC versus AVPV models. Molecular Endocrinology (Baltimore, Md.). me20151189. PMID 26726951 DOI: 10.1210/me.2015-1189  1
2016 Tran DQ, Ramos EH, Belsham DD. Induction of Gnrh mRNA expression by the ω-3 polyunsaturated fatty acid docosahexaenoic acid and the saturated fatty acid palmitate in a GnRH-synthesizing neuronal cell model, mHypoA-GnRH/GFP Molecular and Cellular Endocrinology. 426: 125-135. DOI: 10.1016/j.mce.2016.02.019  1
2015 Oosterman JE, Kalsbeek A, la Fleur SE, Belsham DD. Impact of nutrients on circadian rhythmicity. American Journal of Physiology. Regulatory, Integrative and Comparative Physiology. 308: R337-50. PMID 25519730 DOI: 10.1152/ajpregu.00322.2014  1
2015 Wellhauser L, Gojska NM, Belsham DD. Delineating the regulation of energy homeostasis using hypothalamic cell models. Frontiers in Neuroendocrinology. 36: 130-49. PMID 25223866 DOI: 10.1016/j.yfrne.2014.09.001  1
2014 Gojska NM, Friedman Z, Belsham DD. Direct regulation of gonadotrophin-releasing hormone (GnRH) transcription By RF-amide-related peptide-3 and kisspeptin in a novel gnrh-secreting cell line, mHypoA-GnRH/GFP Journal of Neuroendocrinology. 26: 888-897. PMID 25283492 DOI: 10.1111/jne.12225  1
2014 Greco JA, Oosterman JE, Belsham DD. Differential effects of omega-3 fatty acid docosahexaenoic acid and palmitate on the circadian transcriptional profile of clock genes in immortalized hypothalamic neurons. American Journal of Physiology. Regulatory, Integrative and Comparative Physiology. 307: R1049-60. PMID 25144192 DOI: 10.1152/ajpregu.00100.2014  1
2014 Costford SR, Castro-Alves J, Chan KL, Bailey LJ, Woo M, Belsham DD, Brumell JH, Klip A. Mice lacking NOX2 are hyperphagic and store fat preferentially in the liver. American Journal of Physiology. Endocrinology and Metabolism. 306: E1341-53. PMID 24760992 DOI: 10.1152/ajpendo.00089.2014  1
2014 Wellhauser L, Belsham DD. Activation of the omega-3 fatty acid receptor GPR120 mediates anti-inflammatory actions in immortalized hypothalamic neurons. Journal of Neuroinflammation. 11: 60. PMID 24674717 DOI: 10.1186/1742-2094-11-60  1
2014 Wang ZC, Wheeler MB, Belsham DD. Isolation and immortalization of MIP-GFP neurons from the hypothalamus. Endocrinology. 155: 2314-9. PMID 24617526 DOI: 10.1210/en.2013-2128  1
2014 Son YL, Ubuka T, Narihiro M, Fukuda Y, Hasunuma I, Yamamoto K, Belsham DD, Tsutsui K. Molecular basis for the activation of gonadotropin-inhibitory hormone gene transcription by corticosterone. Endocrinology. 155: 1817-26. PMID 24552400 DOI: 10.1210/en.2013-2076  1
2014 Gojska NM, Belsham DD. Glucocorticoid receptor-mediated regulation of Rfrp (GnIH) and Gpr147 (GnIH-R) synthesis in immortalized hypothalamic neurons. Molecular and Cellular Endocrinology. 384: 23-31. PMID 24412804 DOI: 10.1016/j.mce.2013.12.015  1
2014 Chalmers JA, Jang JJ, Belsham DD. Glucose sensing mechanisms in hypothalamic cell models: glucose inhibition of AgRP synthesis and secretion. Molecular and Cellular Endocrinology. 382: 262-70. PMID 24145125 DOI: 10.1016/j.mce.2013.10.013  1
2014 Nazarians-Armavil A, Chalmers JA, Lee CB, Ye W, Belsham DD. Cellular insulin resistance disrupts hypothalamic mHypoA-POMC/GFP neuronal signaling pathways. The Journal of Endocrinology. 220: 13-24. PMID 24134870 DOI: 10.1530/JOE-13-0334  1
2013 Chandrasekharan B, Jeppsson S, Pienkowski S, Belsham DD, Sitaraman SV, Merlin D, Kokkotou E, Nusrat A, Tansey MG, Srinivasan S. Tumor necrosis factor-neuropeptide Y cross talk regulates inflammation, epithelial barrier functions, and colonic motility. Inflammatory Bowel Diseases. 19: 2535-46. PMID 24108115 DOI: 10.1097/01.MIB.0000437042.59208.9f  1
2013 McFadden SA, Menchella JA, Chalmers JA, Centeno ML, Belsham DD. Glucose responsiveness in a novel adult-derived GnRH cell line, mHypoA-GnRH/GFP: involvement of AMP-activated protein kinase. Molecular and Cellular Endocrinology. 377: 65-74. PMID 23835445 DOI: 10.1016/j.mce.2013.06.035  1
2013 Purser MJ, Dalvi PS, Wang ZC, Belsham DD. The cytokine ciliary neurotrophic factor (CNTF) activates hypothalamic urocortin-expressing neurons both in vitro and in vivo. Plos One. 8: e61616. PMID 23626705 DOI: 10.1371/journal.pone.0061616  1
2013 Nazarians-Armavil A, Menchella JA, Belsham DD. Cellular insulin resistance disrupts leptin-mediated control of neuronal signaling and transcription. Molecular Endocrinology (Baltimore, Md.). 27: 990-1003. PMID 23579487 DOI: 10.1210/me.2012-1338  1
2013 Teodoro-Morrison T, Schuiki I, Zhang L, Belsham DD, Volchuk A. GRP78 overproduction in pancreatic beta cells protects against high-fat-diet-induced diabetes in mice Diabetologia. 56: 1057-1067. PMID 23475366 DOI: 10.1007/s00125-013-2855-7  1
2013 Shao W, Wang D, Chiang YT, Ip W, Zhu L, Xu F, Columbus J, Belsham DD, Irwin DM, Zhang H, Wen X, Wang Q, Jin T. The Wnt signaling pathway effector TCF7L2 controls gut and brain proglucagon gene expression and glucose homeostasis. Diabetes. 62: 789-800. PMID 22966074 DOI: 10.2337/db12-0365  1
2012 Khare T, Pai S, Koncevicius K, Pal M, Kriukiene E, Liutkeviciute Z, Irimia M, Jia P, Ptak C, Xia M, Tice R, Tochigi M, Moréra S, Nazarians A, Belsham D, et al. 5-hmC in the brain is abundant in synaptic genes and shows differences at the exon-intron boundary. Nature Structural & Molecular Biology. 19: 1037-43. PMID 22961382 DOI: 10.1038/nsmb.2372  1
2012 Tung S, Hardy AB, Wheeler MB, Belsham DD. Serotonin (5-HT) activation of immortalized hypothalamic neuronal cells through the 5-HT1B serotonin receptor. Endocrinology. 153: 4862-73. PMID 22919062 DOI: 10.1210/en.2012-1538  1
2012 Chand D, Song L, deLannoy L, Barsyte-Lovejoy D, Ackloo S, Boutros PC, Evans K, Belsham DD, Lovejoy DA. C-Terminal region of teneurin-1 co-localizes with dystroglycan and modulates cytoskeletal organization through an extracellular signal-regulated kinase-dependent stathmin- and filamin A-mediated mechanism in hippocampal cells. Neuroscience. 219: 255-70. PMID 22698694 DOI: 10.1016/j.neuroscience.2012.05.069  1
2012 Dalvi PS, Erbiceanu FD, Irwin DM, Belsham DD. Direct regulation of the proglucagon gene by insulin, leptin, and cAMP in embryonic versus adult hypothalamic neurons. Molecular Endocrinology (Baltimore, Md.). 26: 1339-55. PMID 22669740 DOI: 10.1210/me.2012-1049  1
2012 Dhillon SS, Gingerich S, Virtanen C, Belsham DD. Gene array analysis of embryonic- versus adult-derived hypothalamic NPY-expressing cell lines. Molecular and Cellular Endocrinology. 358: 116-26. PMID 22476083 DOI: 10.1016/j.mce.2012.03.012  1
2012 Dalvi PS, Belsham DD. Glucagon-like peptide-2 directly regulates hypothalamic neurons expressing neuropeptides linked to appetite control in vivo and in vitro. Endocrinology. 153: 2385-97. PMID 22416082 DOI: 10.1210/en.2011-2089  1
2012 Dalvi PS, Nazarians-Armavil A, Purser MJ, Belsham DD. Glucagon-like peptide-1 receptor agonist, exendin-4, regulates feeding-associated neuropeptides in hypothalamic neurons in vivo and in vitro. Endocrinology. 153: 2208-22. PMID 22334721 DOI: 10.1210/en.2011-1795  1
2012 Ng T, Chand D, Song L, Al Chawaf A, Watson JD, Boutros PC, Belsham DD, Lovejoy DA. Identification of a novel brain derived neurotrophic factor (BDNF)-inhibitory factor: regulation of BDNF by teneurin C-terminal associated peptide (TCAP)-1 in immortalized embryonic mouse hypothalamic cells. Regulatory Peptides. 174: 79-89. PMID 22209827 DOI: 10.1016/j.regpep.2011.12.003  1
2011 Kim GL, Wang X, Chalmers JA, Thompson DR, Dhillon SS, Koletar MM, Belsham DD. Generation of immortal cell lines from the adult pituitary: role of cAMP on differentiation of SOX2-expressing progenitor cells to mature gonadotropes. Plos One. 6: e27799. PMID 22132145 DOI: 10.1371/journal.pone.0027799  1
2011 Dhillon SS, McFadden SA, Chalmers JA, Centeno ML, Kim GL, Belsham DD. Cellular leptin resistance impairs the leptin-mediated suppression of neuropeptide Y secretion in hypothalamic neurons. Endocrinology. 152: 4138-47. PMID 21914774 DOI: 10.1210/en.2011-0178  1
2011 Fick LJ, Fick GH, Belsham DD. Palmitate alters the rhythmic expression of molecular clock genes and orexigenic neuropeptide Y mRNA levels within immortalized, hypothalamic neurons. Biochemical and Biophysical Research Communications. 413: 414-9. PMID 21893042 DOI: 10.1016/j.bbrc.2011.08.103  1
2011 Diano S, Liu ZW, Jeong JK, Dietrich MO, Ruan HB, Kim E, Suyama S, Kelly K, Gyengesi E, Arbiser JL, Belsham DD, Sarruf DA, Schwartz MW, Bennett AM, Shanabrough M, et al. Peroxisome proliferation-associated control of reactive oxygen species sets melanocortin tone and feeding in diet-induced obesity. Nature Medicine. 17: 1121-7. PMID 21873987 DOI: 10.1038/nm.2421  1
2011 Cheung S, Fick LJ, Belsham DD, Lovejoy DA, Thompson M. Interfacial behavior of immortalized hypothalamic mouse neurons detected by acoustic wave propagation. The Analyst. 136: 4412-21. PMID 21866285 DOI: 10.1039/c1an15534b  1
2011 Lee FY, Faivre EJ, Suzawa M, Lontok E, Ebert D, Cai F, Belsham DD, Ingraham HA. Eliminating SF-1 (NR5A1) sumoylation in vivo results in ectopic hedgehog signaling and disruption of endocrine development. Developmental Cell. 21: 315-27. PMID 21820362 DOI: 10.1016/j.devcel.2011.06.028  1
2011 Cheung S, Fick LJ, Belsham DD, Thompson M. Synchronization of the circadian rhythm generator and the effects of glucagon on hypothalamic mouse neurons detected by acoustic wave propagation Analyst. 136: 2786-2793. PMID 21594261 DOI: 10.1039/c1an15166e  1
2011 Metlakunta AS, Sahu M, Yasukawa H, Dhillon SS, Belsham DD, Yoshimura A, Sahu A. Neuronal suppressor of cytokine signaling-3 deficiency enhances hypothalamic leptin-dependent phosphatidylinositol 3-kinase signaling. American Journal of Physiology. Regulatory, Integrative and Comparative Physiology. 300: R1185-93. PMID 21325649 DOI: 10.1152/ajpregu.00794.2010  1
2011 Dhillon SS, Belsham DD. Leptin differentially regulates NPY secretion in hypothalamic cell lines through distinct intracellular signal transduction pathways. Regulatory Peptides. 167: 192-200. PMID 21262273 DOI: 10.1016/j.regpep.2011.01.005  1
2011 Dalvi PS, Nazarians-Armavil A, Tung S, Belsham DD. Immortalized neurons for the study of hypothalamic function. American Journal of Physiology. Regulatory, Integrative and Comparative Physiology. 300: R1030-52. PMID 21248304 DOI: 10.1152/ajpregu.00649.2010  1
2011 Dhillon SS, Belsham DD. Estrogen inhibits NPY secretion through membrane-associated estrogen receptor (ER)-α in clonal, immortalized hypothalamic neurons International Journal of Obesity. 35: 198-207. PMID 20548307 DOI: 10.1038/ijo.2010.124  1
2010 Fick LJ, Belsham DD. Nutrient sensing and insulin signaling in neuropeptide-expressing immortalized, hypothalamic neurons: A cellular model of insulin resistance. Cell Cycle (Georgetown, Tex.). 9: 3186-93. PMID 20697199 DOI: 10.4161/cc.9.16.12552  1
2010 Kim GL, Dhillon SS, Belsham DD. Kisspeptin directly regulates neuropeptide Y synthesis and secretion via the ERK1/2 and p38 mitogen-activated protein kinase signaling pathways in NPY-secreting hypothalamic neurons. Endocrinology. 151: 5038-47. PMID 20685868 DOI: 10.1210/en.2010-0521  1
2010 Gingerich S, Kim GL, Chalmers JA, Koletar MM, Wang X, Wang Y, Belsham DD. Estrogen receptor alpha and G-protein coupled receptor 30 mediate the neuroprotective effects of 17β-estradiol in novel murine hippocampal cell models Neuroscience. 170: 54-66. PMID 20619320 DOI: 10.1016/j.neuroscience.2010.06.076  1
2010 Fick LJ, Fick GH, Belsham DD. Rhythmic clock and neuropeptide gene expression in hypothalamic mHypoE-44 neurons. Molecular and Cellular Endocrinology. 323: 298-306. PMID 20211689 DOI: 10.1016/j.mce.2010.02.042  1
2010 Cheung S, Fick LJ, Belsham DD, Thompson M. Depolarization of surface-attached hypothalamic mouse neurons studied by acoustic wave (thickness shear mode) detector Analyst. 135: 289-295. PMID 20098760 DOI: 10.1039/b919430b  1
2010 Mayer CM, Belsham DD. Palmitate attenuates insulin signaling and induces endoplasmic reticulum stress and apoptosis in hypothalamic neurons: rescue of resistance and apoptosis through adenosine 5' monophosphate-activated protein kinase activation. Endocrinology. 151: 576-85. PMID 19952270 DOI: 10.1210/en.2009-1122  1
2010 Mayer CM, Belsham DD. Central insulin signaling is attenuated by long-term insulin exposure via insulin receptor substrate-1 serine phosphorylation, proteasomal degradation, and lysosomal insulin receptor degradation. Endocrinology. 151: 75-84. PMID 19887566 DOI: 10.1210/en.2009-0838  1
2009 Belsham DD, Fick LJ, Dalvi PS, Centeno ML, Chalmers JA, Lee PK, Wang Y, Drucker DJ, Koletar MM. Ciliary neurotrophic factor recruitment of glucagon-like peptide-1 mediates neurogenesis, allowing immortalization of adult murine hypothalamic neurons. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 23: 4256-65. PMID 19703933 DOI: 10.1096/fj.09-133454  1
2009 Wang Y, Belsham DD, Glogauer M. Rac1 and Rac2 in osteoclastogenesis: a cell immortalization model. Calcified Tissue International. 85: 257-66. PMID 19649754 DOI: 10.1007/s00223-009-9274-2  1
2009 Mayer CM, Belsham DD. Insulin directly regulates NPY and AgRP gene expression via the MAPK MEK/ERK signal transduction pathway in mHypoE-46 hypothalamic neurons. Molecular and Cellular Endocrinology. 307: 99-108. PMID 19524132 DOI: 10.1016/j.mce.2009.02.031  1
2009 Labrie V, Fukumura R, Rastogi A, Fick LJ, Wang W, Boutros PC, Kennedy JL, Semeralul MO, Lee FH, Baker GB, Belsham DD, Barger SW, Gondo Y, Wong AH, Roder JC. Serine racemase is associated with schizophrenia susceptibility in humans and in a mouse model. Human Molecular Genetics. 18: 3227-43. PMID 19483194 DOI: 10.1093/hmg/ddp261  1
2009 Gingerich S, Wang X, Lee PKP, Dhillon SS, Chalmers JA, Koletar MM, Belsham DD. The generation of an array of clonal, immortalized cell models from the rat hypothalamus: analysis of melatonin effects on kisspeptin and gonadotropin-inhibitory hormone neurons Neuroscience. 162: 1134-1140. PMID 19463905 DOI: 10.1016/j.neuroscience.2009.05.026  1
2009 Dhillon SS, Gingerich S, Belsham DD. Neuropeptide Y induces gonadotropin-releasing hormone gene expression directly and through conditioned medium from mHypoE-38 NPY neurons. Regulatory Peptides. 156: 96-103. PMID 19371763 DOI: 10.1016/j.regpep.2009.04.005  1
2009 Mayer CM, Fick LJ, Gingerich S, Belsham DD. Hypothalamic cell lines to investigate neuroendocrine control mechanisms. Frontiers in Neuroendocrinology. 30: 405-23. PMID 19341762 DOI: 10.1016/j.yfrne.2009.03.005  1
2009 Fick LJ, Cai F, Belsham DD. Hypothalamic preproghrelin gene expression is repressed by insulin via both PI3-K/Akt and ERK1/2 MAPK pathways in immortalized, hypothalamic neurons. Neuroendocrinology. 89: 267-75. PMID 18957841 DOI: 10.1159/000167698  1
2008 Madadi G, Dalvi PS, Belsham DD. Regulation of brain insulin mRNA by glucose and glucagon-like peptide 1. Biochemical and Biophysical Research Communications. 376: 694-9. PMID 18809381 DOI: 10.1016/j.bbrc.2008.09.054  1
2008 Chalmers JA, Martino TA, Tata N, Ralph MR, Sole MJ, Belsham DD. Vascular circadian rhythms in a mouse vascular smooth muscle cell line (Movas-1). American Journal of Physiology. Regulatory, Integrative and Comparative Physiology. 295: R1529-38. PMID 18768761 DOI: 10.1152/ajpregu.90572.2008  1
2008 Titolo D, Mayer CM, Dhillon SS, Cai F, Belsham DD. Estrogen facilitates both phosphatidylinositol 3-kinase/Akt and ERK1/2 mitogen-activated protein kinase membrane signaling required for long-term neuropeptide Y transcriptional regulation in clonal, immortalized neurons. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 28: 6473-82. PMID 18562618 DOI: 10.1523/JNEUROSCI.0514-08.2008  1
2008 Chalmers JA, Lin SY, Martino TA, Arab S, Liu P, Husain M, Sole MJ, Belsham DD. Diurnal profiling of neuroendocrine genes in murine heart, and shift in proopiomelanocortin gene expression with pressure-overload cardiac hypertrophy. Journal of Molecular Endocrinology. 41: 117-24. PMID 18550896 DOI: 10.1677/JME-08-0050  1
2008 Martino TA, Oudit GY, Herzenberg AM, Tata N, Koletar MM, Kabir GM, Belsham DD, Backx PH, Ralph MR, Sole MJ. Circadian rhythm disorganization produces profound cardiovascular and renal disease in hamsters. American Journal of Physiology. Regulatory, Integrative and Comparative Physiology. 294: R1675-83. PMID 18272659 DOI: 10.1152/ajpregu.00829.2007  1
2008 Cheng H, Isoda F, Belsham DD, Mobbs CV. Inhibition of agouti-related peptide expression by glucose in a clonal hypothalamic neuronal cell line is mediated by glycolysis, not oxidative phosphorylation. Endocrinology. 149: 703-10. PMID 17974626 DOI: 10.1210/en.2007-0772  1
2008 Martino TA, Oudit GY, Herzenberg AH, Tata N, Koletar MM, Kabir GM, Belsham DD, Backx PH, Ralph MR, Sole MJ. Circadian rhythm disorganization produces profound cardiovascular and renal disease in hamsters (American Journal of Physiology Regulatory Integrative and Comparative Physiology (2008) 294, (R1675-R1683) DOI:10.1152/ajpregu.00829.2007) American Journal of Physiology - Regulatory Integrative and Comparative Physiology. 295: R369. DOI: 10.1152/ajpregu.zh6-6398-corr.2008  1
2007 Belsham DD. Hormonal regulation of clonal, immortalized hypothalamic neurons expressing neuropeptides involved in reproduction and feeding. Molecular Neurobiology. 35: 182-94. PMID 17917107 DOI: 10.1007/s12035-007-0010-5  1
2007 Trubiani G, Al Chawaf A, Belsham DD, Barsyte-Lovejoy D, Lovejoy DA. Teneurin carboxy (C)-terminal associated peptide-1 inhibits alkalosis-associated necrotic neuronal death by stimulating superoxide dismutase and catalase activity in immortalized mouse hypothalamic cells. Brain Research. 1176: 27-36. PMID 17900539 DOI: 10.1016/j.brainres.2007.07.087  1
2007 Brown R, Imran SA, Belsham DD, Ur E, Wilkinson M. Adipokine gene expression in a novel hypothalamic neuronal cell line: resistin-dependent regulation of fasting-induced adipose factor and SOCS-3. Neuroendocrinology. 85: 232-41. PMID 17579277 DOI: 10.1159/000104248  1
2007 Martino TA, Tata N, Belsham DD, Chalmers J, Straume M, Lee P, Pribiag H, Khaper N, Liu PP, Dawood F, Backx PH, Ralph MR, Sole MJ. Disturbed diurnal rhythm alters gene expression and exacerbates cardiovascular disease with rescue by resynchronization. Hypertension. 49: 1104-13. PMID 17339537 DOI: 10.1161/HYPERTENSIONAHA.106.083568  1
2007 Cai F, Gyulkhandanyan AV, Wheeler MB, Belsham DD. Glucose regulates AMP-activated protein kinase activity and gene expression in clonal, hypothalamic neurons expressing proopiomelanocortin: additive effects of leptin or insulin. The Journal of Endocrinology. 192: 605-14. PMID 17332528 DOI: 10.1677/JOE-06-0080  1
2007 Cheran LE, Cheung S, Al Chawaf A, Ellis JS, Belsham DD, MacKay WA, Lovejoy D, Thompson M. Label-free detection of neuron-drug interactions using acoustic and Kelvin vibrational fields. The Analyst. 132: 242-55. PMID 17325758 DOI: 10.1039/b615476j  1
2007 Al Chawaf A, St Amant K, Belsham D, Lovejoy DA. Regulation of neurite growth in immortalized mouse hypothalamic neurons and rat hippocampal primary cultures by teneurin C-terminal-associated peptide-1. Neuroscience. 144: 1241-54. PMID 17174479 DOI: 10.1016/j.neuroscience.2006.09.062  1
2006 Cui H, Cai F, Belsham DD. Leptin signaling in neurotensin neurons involves STAT, MAP kinases ERK1/2, and p38 through c-Fos and ATF1. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 20: 2654-6. PMID 17077290 DOI: 10.1096/fj.06-5989fje  1
2006 Piessevaux J, Lavens D, Montoye T, Wauman J, Catteeuw D, Vandekerckhove J, Belsham D, Peelman F, Tavernier J. Functional cross-modulation between SOCS proteins can stimulate cytokine signaling. The Journal of Biological Chemistry. 281: 32953-66. PMID 16956890 DOI: 10.1074/jbc.M600776200  1
2006 Nguyen KT, Tajmir P, Lin CH, Liadis N, Zhu XD, Eweida M, Tolasa-Karaman G, Cai F, Wang R, Kitamura T, Belsham DD, Wheeler MB, Suzuki A, Mak TW, Woo M. Essential role of Pten in body size determination and pancreatic beta-cell homeostasis in vivo. Molecular and Cellular Biology. 26: 4511-8. PMID 16738317 DOI: 10.1128/MCB.00238-06  1
2006 Titolo D, Cai F, Belsham DD. Coordinate regulation of neuropeptide Y and agouti-related peptide gene expression by estrogen depends on the ratio of estrogen receptor (ER) alpha to ERbeta in clonal hypothalamic neurons. Molecular Endocrinology (Baltimore, Md.). 20: 2080-92. PMID 16675543 DOI: 10.1210/me.2006-0027  1
2005 Cui H, Cai F, Belsham DD. Anorexigenic hormones leptin, insulin, and alpha-melanocyte-stimulating hormone directly induce neurotensin (NT) gene expression in novel NT-expressing cell models. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 25: 9497-506. PMID 16221860 DOI: 10.1523/JNEUROSCI.2269-05.2005  1
2005 Belsham DD, Lovejoy DA. Gonadotropin-releasing hormone: gene evolution, expression, and regulation. Vitamins and Hormones. 71: 59-94. PMID 16112265 DOI: 10.1016/S0083-6729(05)71003-7  1
2005 Wang L, Rotzinger S, Al Chawaf A, Elias CF, Barsyte-Lovejoy D, Qian X, Wang NC, De Cristofaro A, Belsham D, Bittencourt JC, Vaccarino F, Lovejoy DA. Teneurin proteins possess a carboxy terminal sequence with neuromodulatory activity. Brain Research. Molecular Brain Research. 133: 253-65. PMID 15710242 DOI: 10.1016/j.molbrainres.2004.10.019  1
2004 Bai F, Rankinen T, Charbonneau C, Belsham DD, Rao DC, Bouchard C, Argyropoulos G. Functional dimorphism of two hAgRP promoter SNPs in linkage disequilibrium. Journal of Medical Genetics. 41: 350-3. PMID 15121772  1
2004 Lin SY, Cui H, Yusta B, Belsham DD. IGF-I signaling prevents dehydroepiandrosterone (DHEA)-induced apoptosis in hypothalamic neurons. Molecular and Cellular Endocrinology. 214: 127-35. PMID 15062551 DOI: 10.1016/j.mce.2003.10.064  1
2004 Gillespie JM, Roy D, Cui H, Belsham DD. Repression of gonadotropin-releasing hormone (GnRH) gene expression by melatonin may involve transcription factors COUP-TFI and C/EBP beta binding at the GnRH enhancer. Neuroendocrinology. 79: 63-72. PMID 15004428 DOI: 10.1159/000076629  1
2004 Martino T, Arab S, Straume M, Belsham DD, Tata N, Cai F, Liu P, Trivieri M, Ralph M, Sole MJ. Day/night rhythms in gene expression of the normal murine heart. Journal of Molecular Medicine (Berlin, Germany). 82: 256-64. PMID 14985853 DOI: 10.1007/s00109-003-0520-1  1
2004 Belsham DD, Cai F, Cui H, Smukler SR, Salapatek AM, Shkreta L. Generation of a phenotypic array of hypothalamic neuronal cell models to study complex neuroendocrine disorders. Endocrinology. 145: 393-400. PMID 14551229 DOI: 10.1210/en.2003-0946  1
2003 Gillespie JM, Chan BP, Roy D, Cai F, Belsham DD. Expression of circadian rhythm genes in gonadotropin-releasing hormone-secreting GT1-7 neurons. Endocrinology. 144: 5285-92. PMID 12960008 DOI: 10.1210/en.2003-0802  1
2003 Mayer CM, Cai F, Cui H, Gillespie JM, MacMillan M, Belsham DD. Analysis of a repressor region in the human neuropeptide Y gene that binds Oct-1 and Pbx-1 in GT1-7 neurons. Biochemical and Biophysical Research Communications. 307: 847-54. PMID 12878188 DOI: 10.1016/S0006-291X(03)01289-0  1
2003 Cui H, Lin SY, Belsham DD. Evidence that dehydroepiandrosterone, DHEA, directly inhibits GnRH gene expression in GT1-7 hypothalamic neurons. Molecular and Cellular Endocrinology. 203: 13-23. PMID 12782399 DOI: 10.1016/S0303-7207(03)00121-7  1
2002 Shakil T, Hoque AN, Husain M, Belsham DD. Differential regulation of gonadotropin-releasing hormone secretion and gene expression by androgen: membrane versus nuclear receptor activation. Molecular Endocrinology (Baltimore, Md.). 16: 2592-602. PMID 12403848 DOI: 10.1210/me.2002-0011  1
2002 Roy D, Belsham DD. Melatonin receptor activation regulates GnRH gene expression and secretion in GT1-7 GnRH neurons. Signal transduction mechanisms. The Journal of Biological Chemistry. 277: 251-8. PMID 11684691 DOI: 10.1074/jbc.M108890200  1
2001 Roy D, Angelini NL, Fujieda H, Brown GM, Belsham DD. Cyclical regulation of GnRH gene expression in GT1-7 GnRH-secreting neurons by melatonin. Endocrinology. 142: 4711-20. PMID 11606436 DOI: 10.1210/endo.142.11.8464  1
2000 Belsham DD, Mellon PL. Transcription factors Oct-1 and C/EBP/β (CCAAT/enhancer-binding protein-β) are involved in the glutamate/nitric oxide/cyclic-guanosine 5′-monophosphate-mediated repression of gonadotropin-releasing hormone gene expression Molecular Endocrinology. 14: 212-228. PMID 10674395 DOI: 10.1210/me.14.2.212  1
1999 Roy D, Angelini NL, Belsham DD. Estrogen Directly Represses Gonadotropin-Releasing Hormone (GnRH) Gene Expression in Estrogen Receptor-α (ERα)- and ERβ-Expressing GT1-7 GnRH Neurons1. Endocrinology. 140: 5045-5053. PMID 28200766 DOI: 10.1210/endo.140.11.7117  1
1999 Roy D, Angelini NL, Belsham DD. Estrogen directly respresses gonadotropin-releasing hormone (GnRH) gene expression in estrogen receptor-alpha (ERalpha)- and ERbeta-expressing GT1-7 GnRH neurons. Endocrinology. 140: 5045-53. PMID 10537130 DOI: 10.1210/endo.140.11.7117  1
1998 Belsham DD, Evangelou A, Roy D, Le DV, Brown TJ. Regulation of Gonadotropin-Releasing Hormone (GnRH) Gene Expression by 5α-Dihydrotestosterone in GnRH-Secreting GT1-7 Hypothalamic Neurons. Endocrinology. 139: 1108-1114. PMID 28200355 DOI: 10.1210/endo.139.3.5846  1
1998 Belsham DD, Evangelou A, Roy D, Le DV, Brown TJ. Regulation of gonadotropin-releasing hormone (GnRH) gene expression by 5α-dihydrotestosterone in GnRH-secreting GT1-7 hypothalamic neurons Endocrinology. 139: 1108-1114. PMID 9492044 DOI: 10.1210/en.139.3.1108  1
1997 Clark ME, Lawson MA, Belsham DD, Eraly SA, Mellon PL. Chapter 1 Molecular aspects of GnRH gene expression Advances in Molecular and Cellular Endocrinology. 1: 1-30. DOI: 10.1016/S1569-2566(97)80032-4  1
1996 Belsham DD, Wetsel WC, Mellon PL. NMDA and nitric oxide act through the cGMP signal transduction pathway to repress hypothalamic gonadotropin-releasing hormone gene expression. The Embo Journal. 15: 538-47. PMID 8599937  1
1995 Whyte DB, Lawson MA, Belsham DD, Eraly SA, Bond CT, Adelman JP, Mellon PL. A neuron-specific enhancer targets expression of the gonadotropin-releasing hormone gene to hypothalamic neurosecretory neurons Molecular Endocrinology. 9: 467-477. PMID 7659090  1
1995 Belsham DD, Pereira F, Greenberg CR, Liao S, Wrogemann K. Leu‐676‐Pro mutation of the androgen receptor causes complete androgen insensitivity syndrome in a large Hutterite kindred Human Mutation. 5: 28-33. PMID 7537149 DOI: 10.1002/humu.1380050104  1
1995 Mellon PL, Eraly SA, Belsham DD, Lawson MA, Clark ME, Whyte DB, Windle JJ. An Immortal Cell Culture Model of Hypothalamic Gonadotropin-Releasing Hormone Neurons Methods. 7: 303-310. DOI: 10.1006/meth.1995.1036  1
1993 Keely EJ, Belsham DD, Wrogemann K, Faiman C. Partial androgen insensitivity - Are all tissues equal? Fertility and Sterility. 60: 366-368. PMID 8339840  1
1992 Prior L, Bordet S, Trifiro MA, Mhatre A, Kaufman M, Pinsky L, Wrogeman K, Belsham DD, Pereira F, Greenberg C, Trapman J, Brinkman AO, Chang C, Liao S. Replacement of arginine 773 by cysteine or histidine in the human androgen receptor causes complete androgen insensitivity with different receptor phenotypes American Journal of Human Genetics. 51: 143-155. PMID 1609793  1
1992 Belsham DD, Yee WC, Greenberg CR, Wrogemann K. Analysis of the CAG repeat region of the androgen receptor gene in a kindred with X-linked spinal and bulbar muscular atrophy Journal of the Neurological Sciences. 112: 133-138. PMID 1469423 DOI: 10.1016/0022-510X(92)90142-8  1
1991 Trifiro M, Gottlieb B, Pinsky L, Kaufman M, Prior L, Belsham DD, Wrogemann K, Brown CJ, Willard HF, Trapman J, Brinkmann AO, Chang C, Liao S, Sergovich F, Jung J. The 56/58 kDa androgen-binding protein in male genital skin fibroblasts with a deleted androgen receptor gene Molecular and Cellular Endocrinology. 75: 37-47. PMID 2050265 DOI: 10.1016/0303-7207(91)90243-L  1
1991 Trifiro M, Prior RL, Sabbaghian N, Pinsky L, Kaufman M, Nylen EG, Belsham DD, Greenberg CR, Wrogemann K. Amber mutation creates a diagnostic MaeI site in the androgen receptor gene of a family with complete androgen insensitivity American Journal of Medical Genetics. 40: 493-499. PMID 1720929  1
1990 Pereira F, Belsham D, Duerksen K, Rosenmann E, Kaufman M, Pinsky L, Wrogemann K. The 56 kDa androgen-binding protein in human genital skin fibroblasts: its relation to the human androgen receptor Molecular and Cellular Endocrinology. 68: 195-204. PMID 2311825 DOI: 10.1016/0303-7207(90)90193-C  1
1989 Belsham DD, Rosenmann E, Pereira FA, Williams SG, Turney MK, Kovacs WJ, Faber LE, Wrogemann K. The 56 kDa protein of human genital skin fibroblasts is identical to that radiolabelled by [3H]dihydrotestosterone 17β-bromoacetate Journal of Steroid Biochemistry. 33: 389-394. PMID 2779230 DOI: 10.1016/0022-4731(89)90328-2  1
1988 Wrogemann K, Pereira F, Belsham D, Kaufman M, Pinsky L, Rosenmann E. An abundant 56 kD protein with low affinity androgen binding: Another member of the steroid/thyroid receptor family? Biochemical and Biophysical Research Communications. 155: 907-913. PMID 3262343 DOI: 10.1016/S0006-291X(88)80582-5  1
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