Year |
Citation |
Score |
2006 |
O'Brian CA, Chu F, Bornmann WG, Maxwell DS. Protein kinase Calpha and epsilon small-molecule targeted therapeutics: a new roadmap to two Holy Grails in drug discovery? Expert Review of Anticancer Therapy. 6: 175-86. PMID 16445370 DOI: 10.1586/14737140.6.2.175 |
0.457 |
|
2005 |
Chu F, Koomen JM, Kobayashi R, O'Brian CA. Identification of an inactivating cysteine switch in protein kinase Cepsilon, a rational target for the design of protein kinase Cepsilon-inhibitory cancer therapeutics. Cancer Research. 65: 10478-85. PMID 16288040 DOI: 10.1158/0008-5472.Can-05-1989 |
0.433 |
|
2005 |
O'Brian CA, Chu F. Post-translational disulfide modifications in cell signaling--role of inter-protein, intra-protein, S-glutathionyl, and S-cysteaminyl disulfide modifications in signal transmission. Free Radical Research. 39: 471-80. PMID 16036322 DOI: 10.1080/10715760500073931 |
0.355 |
|
2005 |
Chu F, O'Brian CA. PKC sulfhydryl targeting by disulfiram produces divergent isozymic regulatory responses that accord with the cancer preventive activity of the thiuram disulfide. Antioxidants & Redox Signaling. 7: 855-62. PMID 15998240 DOI: 10.1089/ars.2005.7.855 |
0.414 |
|
2005 |
Stewart JR, O'Brian CA. Protein kinase C-{alpha} mediates epidermal growth factor receptor transactivation in human prostate cancer cells. Molecular Cancer Therapeutics. 4: 726-32. PMID 15897236 DOI: 10.1158/1535-7163.Mct-05-0013 |
0.6 |
|
2004 |
Stewart JR, O'Brian CA. Resveratrol antagonizes EGFR-dependent Erk1/2 activation in human androgen-independent prostate cancer cells with associated isozyme-selective PKC alpha inhibition. Investigational New Drugs. 22: 107-17. PMID 14739659 DOI: 10.1023/B:Drug.0000011787.75522.Ec |
0.646 |
|
2004 |
Chu F, Chen LH, O'Brian CA. Cellular protein kinase C isozyme regulation by exogenously delivered physiological disulfides--implications of oxidative protein kinase C regulation to cancer prevention. Carcinogenesis. 25: 585-96. PMID 14656938 DOI: 10.1093/carcin/bgh041 |
0.375 |
|
2003 |
O'Brian CA, Ward NE, Chu F, Stewart JR. Irreversible inactivation of protein kinase C isozymes by thiol-reactive peptide substrate analogs. Methods in Molecular Biology (Clifton, N.J.). 233: 441-9. PMID 12840527 DOI: 10.1385/1-59259-397-6:441 |
0.6 |
|
2003 |
Stewart JR, Artime MC, O'Brian CA. Resveratrol: a candidate nutritional substance for prostate cancer prevention. The Journal of Nutrition. 133: 2440S-2443S. PMID 12840221 DOI: 10.1093/Jn/133.7.2440S |
0.559 |
|
2003 |
Chu F, Ward NE, O'Brian CA. PKC isozyme S-cysteinylation by cystine stimulates the pro-apoptotic isozyme PKC delta and inactivates the oncogenic isozyme PKC epsilon. Carcinogenesis. 24: 317-25. PMID 12584183 DOI: 10.1093/carcin/24.2.317 |
0.377 |
|
2002 |
Castilleja A, Ward NE, Epstein RB, Kudelka AP, Gershenson DM, Efferson CL, O'Brian CA, Ioannides CG. Treatment with HER-2 phosphorylation agonists enhance tumor ability to stimulate epitope specific CTL in vitro. Oncology Reports. 9: 929-35. PMID 12168050 DOI: 10.3892/Or.9.5.929 |
0.377 |
|
2002 |
Ward NE, Chu F, O'Brian CA. Regulation of protein kinase C isozyme activity by S-glutathiolation. Methods in Enzymology. 353: 89-100. PMID 12078531 DOI: 10.1016/S0076-6879(02)53039-1 |
0.359 |
|
2001 |
O'Brian CA, Ward NE, Stewart JR, Chu F. Prospects for targeting protein kinase C isozymes in the therapy of drug-resistant cancer--an evolving story. Cancer Metastasis Reviews. 20: 95-100. PMID 11831653 DOI: 10.1023/A:1013186430906 |
0.628 |
|
2001 |
Bedikian AY, Plager C, Stewart JR, O'Brian CA, Herdman SK, Ross M, Papadopoulos N, Eton O, Ellerhorst J, Smith T. Phase II evaluation of bryostatin-1 in metastatic melanoma. Melanoma Research. 11: 183-8. PMID 11333129 DOI: 10.1097/00008390-200104000-00014 |
0.447 |
|
2000 |
Stewart JR, Christman KL, O'Brian CA. Effects of resveratrol on the autophosphorylation of phorbol ester-responsive protein kinases: inhibition of protein kinase D but not protein kinase C isozyme autophosphorylation. Biochemical Pharmacology. 60: 1355-9. PMID 11008129 DOI: 10.1016/S0006-2952(00)00450-0 |
0.644 |
|
2000 |
Ward NE, Stewart JR, Ioannides CG, O'Brian CA. Oxidant-induced S-glutathiolation inactivates protein kinase C-alpha (PKC-alpha): a potential mechanism of PKC isozyme regulation. Biochemistry. 39: 10319-29. PMID 10956021 DOI: 10.1021/Bi000781G |
0.548 |
|
2000 |
O'Brian CA, Stewart JR, Ward NE, Bergman PJ. Regulatory mechanisms governing protein kinase C signaling Electronic Journal of Pathology and Histology. 6: 110-120. |
0.399 |
|
1999 |
Stewart JR, Ward NE, Ioannides CG, O'Brian CA. Resveratrol preferentially inhibits protein kinase C-catalyzed phosphorylation of a cofactor-independent, arginine-rich protein substrate by a novel mechanism. Biochemistry. 38: 13244-51. PMID 10529197 DOI: 10.1021/Bi990875U |
0.649 |
|
1999 |
Ward NE, Pierce DS, Stewart JR, O'brian CA. A peptide substrate-based affinity label blocks protein kinase C-catalyzed ATP hydrolysis and peptide-substrate phosphorylation. Archives of Biochemistry and Biophysics. 365: 248-53. PMID 10328819 DOI: 10.1006/Abbi.1999.1164 |
0.645 |
|
1999 |
Ward NE, Fan G, O'Brian CA. Differential non-redox inhibitory effects of glutathione against protein kinase C isozyme family members Oncology Reports. 6: 307-310. PMID 10022994 DOI: 10.3892/Or.6.2.307 |
0.478 |
|
1998 |
Bruins RH, Annable C, Ward NE, Gravitt KR, O'Brian CA, Epand RM. Evidence for a regulatory binding site for arginine-rich peptides on protein kinase C1 Archives of Biochemistry and Biophysics. 356: 258-264. PMID 9705216 DOI: 10.1006/Abbi.1998.0766 |
0.426 |
|
1998 |
Ward NE, Pierce DS, Chung SE, Gravitt KR, O'Brian CA. Irreversible inactivation of protein kinase C by glutathione Journal of Biological Chemistry. 273: 12558-12566. PMID 9575216 DOI: 10.1074/jbc.273.20.12558 |
0.4 |
|
1998 |
O'Brian CA. Protein kinase C-α: A novel target for the therapy of androgen- independent prostate cancer? (Review-hypothesis) Oncology Reports. 5: 305-309. PMID 9468546 DOI: 10.3892/Or.5.2.305 |
0.409 |
|
1997 |
Bergman PJ, Gravitt KR, Ward NE, Beltran P, Gupta KP, O'Brian CA. Potent induction of human colon cancer cell uptake of chemotherapeutic drugs by N-myristoylated protein kinase C-α (PKC-α) pseudosubstrate peptides through a P-glycoprotein-independent mechanism Investigational New Drugs. 15: 311-318. PMID 9547673 DOI: 10.1023/A:1005933401603 |
0.471 |
|
1997 |
Bergman PJ, Gravitt KR, O'Brian CA. An N-myristoylated protein kinase C-α pseudosubstrate peptide that functions as a multidrug resistance reversal agent in human breast cancer cells is not a P-glycoprotein substrate Cancer Chemotherapy and Pharmacology. 40: 453-456. PMID 9272125 DOI: 10.1007/s002800050686 |
0.342 |
|
1997 |
Beltran PJ, Fan D, Fidler IJ, O'Brian CA. Chemosensitization of cancer cells by the staurosporine derivative CGP 41251 in association with decreased P-glycoprotein phosphorylation Biochemical Pharmacology. 53: 245-247. PMID 9037258 DOI: 10.1016/S0006-2952(96)00718-6 |
0.444 |
|
1996 |
Ward NE, Gravitt KR, O'Brian CA. Covalent Modification of Protein Kinase C Isozymes by the Inactivating Peptide Substrate Analog N-Biotinyl-Arg-Arg-Arg-Cys-Leu-Arg-Arg-Leu EVIDENCE THAT THE BIOTINYLATED PEPTIDE IS AN ACTIVE-SITE AFFINITY LABEL Journal of Biological Chemistry. 271: 24193-24200. PMID 8798661 DOI: 10.1074/Jbc.271.39.24193 |
0.398 |
|
1996 |
Gupta KP, Ward NE, Gravitt KR, Bergman PJ, O'Brian CA. Partial reversal of multidrug resistance in human breast cancer cells by an N-myristoylated protein kinase C-α pseudosubstrate peptide Journal of Biological Chemistry. 271: 2102-2111. PMID 8567666 DOI: 10.1074/Jbc.271.4.2102 |
0.427 |
|
1995 |
O'Brian CA, Ward NE, Gravitt KR, Gupta KP. The tumor promoter receptor protein kinase C: a novel target for chemoprevention and therapy of human colon cancer Progress in Clinical and Biological Research. 391: 117-120. PMID 8532710 |
0.359 |
|
1995 |
Ward NE, Gravitt KR, O'Brian CA. Inhibition of protein kinase C by a synthetic peptide corresponding to cytoplasmic domain residues 828-848 of the human immunodeficiency virus type 1 envelope glycoprotein Cancer Letters. 88: 37-40. PMID 7850771 DOI: 10.1016/0304-3835(94)03610-U |
0.491 |
|
1995 |
Ward NE, Gravitt KR, O'Brian CA. Irreversible inactivation of protein kinase C by a peptide-substrate analog Journal of Biological Chemistry. 270: 8056-8060. PMID 7713907 DOI: 10.1074/Jbc.270.14.8056 |
0.481 |
|
1994 |
Gravitt KR, Ward NE, O'Brian CA. Inhibition of protein kinase C by melittin: antagonism of binding interactions between melittin and the catalytic domain by active-site binding of MgATP Biochemical Pharmacology. 47: 425-427. PMID 8304988 DOI: 10.1016/0006-2952(94)90037-X |
0.377 |
|
1994 |
Gravitt KR, Ward NE, Fan D, Skibber JM, Levin B, O'Brian CA. Evidence that protein kinase C-α activation is a critical event in phorbol ester-induced multiple drug resistance in human colon cancer cells Biochemical Pharmacology. 48: 375-381. PMID 8053934 DOI: 10.1016/0006-2952(94)90110-4 |
0.429 |
|
1994 |
O'Brian CA, Ward NE, Gravitt KR, Fan D. The role of protein kinase C in multidrug resistance Cancer Treatment and Research. 73: 41-55. PMID 7710909 |
0.316 |
|
1994 |
O'Brian CA, Ward NE, Vogel VG. Inhibition of Protein Kinase C by the 12-O-tetradecanoylphorbol-13-acetate antagonist glycyrrhetic acid Chemosphere. 29: 9-12. DOI: 10.1016/0304-3835(90)90132-H |
0.406 |
|
1993 |
Dong Z, O'Brian CA, Fidler IJ. Activation of tumoricidal properties in macrophages by lipopolysaccharide requires protein-tyrosine kinase activity Journal of Leukocyte Biology. 53: 53-60. PMID 8426092 DOI: 10.1002/Jlb.53.1.53 |
0.387 |
|
1993 |
O'Brian CA. Inhibition of protein kinase C by N-myristoylated peptide substrate analogs Biochemistry®. 32: 11903-11909. PMID 8218262 |
0.375 |
|
1993 |
Ioannides CG, Fisk B, Fan D, Biddison WE, Wharton JT, O'Brian CA. Cytotoxic T cells isolated from ovarian malignant ascites recognize a peptide derived from the HER-2/neu proto-oncogene Cellular Immunology. 151: 225-234. PMID 7691418 DOI: 10.1006/Cimm.1993.1233 |
0.326 |
|
1992 |
Fan D, Fidler IJ, Ward NE, Seid C, Earnest LE, Housey GM, O'Brian CA. Stable expression of a cDNA encoding rat brain protein kinase C-βI confers a multidrug-resistant phenotype on rat fibroblasts Anticancer Research. 12: 661-667. PMID 1622123 |
0.332 |
|
1992 |
Ward NE, O'Brian CA. Kinetic analysis of protein kinase C inhibition by staurosporine: Evidence that inhibition entails inhibitor binding at a conserved region of the catalytic domain but not competition with substrates Molecular Pharmacology. 41: 387-392. PMID 1538715 |
0.381 |
|
1992 |
Ward NE, O'Brian CA. The intrinsic ATPase activity of protein kinase C is catalyzed at the active site of the enzyme Biochemistry. 31: 5905-5911. PMID 1535219 |
0.393 |
|
1992 |
Wilmanns C, Fan D, O'Brian CA, Bucana CD, Fidler IJ. Orthotopic and ectopic organ environments differentially influence the sensitivity of murine colon carcinoma cells to doxorubicin and 5-fluorouracil International Journal of Cancer. 52: 98-104. PMID 1500231 DOI: 10.1002/Ijc.2910520118 |
0.318 |
|
1991 |
Dong Z, Ward NE, Fan D, Gupta KP, O'Brian CA. In vitro model for intrinsic drug resistance: Effects of protein kinase C activators on the chemosensitivity of cultured human colon cancer cells Molecular Pharmacology. 39: 563-569. PMID 2017156 |
0.384 |
|
1991 |
O'Brian CA, Fan D, Ward NE, Dong Z, Iwamoto L, Gupta KP, Earnest LE, Fidler IJ. Transient enhancement of multidrug resistance by the bile acid deoxycholate in murine fibrosarcoma cells in vitro Biochemical Pharmacology. 41: 797-806. PMID 1998534 DOI: 10.1016/0006-2952(91)90083-H |
0.422 |
|
1991 |
O'Brian CA, Ward NE, Liskamp RM, de Bont DB, Earnest LE, van Boom JH, Fan D. A novel N-myristylated synthetic octapeptide inhibits protein kinase C activity and partially reverses murine fibrosarcoma cell resistance to Adriamycin Investigational New Drugs. 9: 169-179. PMID 1874600 DOI: 10.1007/Bf00175084 |
0.503 |
|
1991 |
Ward NE, O'Brian CA. Distinct patterns of phorbol ester-induced downregulation of protein kinase C activity in adriamycin-selected multidrug resistant and parental murine fibrosarcoma cells Cancer Letters. 58: 189-193. PMID 1855195 DOI: 10.1016/0304-3835(91)90099-4 |
0.46 |
|
1991 |
O'Brian CA, Ward NE. Stimulation of the ATPase activity of rat brain protein kinase C by phospho acceptor substrates of the enzyme Biochemistry. 30: 2549-2554. PMID 1848101 DOI: 10.1021/Bi00223A036 |
0.484 |
|
1990 |
Bucana CD, Giavazzi R, Nayar R, O'Brian CA, Seid C, Earnest LE, Fan D. Retention of vital dyes correlates inversely with the multidrug-resistant phenotype of adriamycin-selected murine fibrosarcoma variants Experimental Cell Research. 190: 69-75. PMID 2387329 DOI: 10.1016/0014-4827(90)90145-Z |
0.35 |
|
1990 |
Gottlieb RA, Kleinerman ES, O'Brian CA, Tsujimoto S, Cianciolo GJ, Lennarz WJ. Inhibition of protein kinase C by a peptide conjugate homologous to a domain of the retroviral protein p15E. Journal of Immunology (Baltimore, Md. : 1950). 145: 2566-70. PMID 2212653 |
0.433 |
|
1990 |
O'Brian CA, Ward NE. Characterization of a Ca2+- and phospholipid-dependent ATPase reaction catalyzed by rat brain protein kinase C Biochemistry. 29: 4278-4282. PMID 2161679 DOI: 10.1021/Bi00470A003 |
0.487 |
|
1990 |
O'Brian CA, Ioannides CG, Ward NE, Liskamp RM. Inhibition of protein kinase C and calmodulin by the geometric isomers cis- and trans-tamoxifen Biopolymers. 29: 97-104. PMID 2158363 DOI: 10.1002/Bip.360290114 |
0.405 |
|
1990 |
O'Brian CA, Ward NE, Liskamp RM, de Bont DB, van Boom JH. N-myristyl-Lys-Arg-Thr-Leu-Arg: A novel protein kinase C inhibitor Biochemical Pharmacology. 39: 49-57. PMID 2153382 DOI: 10.1016/0006-2952(90)90647-4 |
0.391 |
|
1990 |
Ioannides CG, Freedman RS, Liskamp RM, Ward NE, O'Brian CA. Inhibition of IL-2 receptor induction and IL-2 production in the human leukemic cell line Jurkat by a novel peptide inhibitor of protein kinase C Cellular Immunology. 131: 242-252. PMID 2121373 DOI: 10.1016/0008-8749(90)90250-U |
0.365 |
|
1989 |
O'Brian CA, Ward NE. ATP-sensitive binding of melittin to the catalytic domain of protein kinase C Molecular Pharmacology. 36: 355-359. PMID 2779522 |
0.373 |
|
1989 |
O'brian CA, Ward NE. Binding of protein kinase C to N-(6-aminohexyl)-5-chloro-1-naphthalenesulfonamide through its ATP binding site Biochemical Pharmacology. 38: 1737-1742. PMID 2735931 DOI: 10.1016/0006-2952(89)90406-1 |
0.484 |
|
1989 |
De Bont HBA, Liskamp RMJ, O'Brian CA, Erkelens C, Veeneman GH, Van Boom JH. Synthesis of a substrate of protein kinase C and its corresponding phosphopeptide International Journal of Peptide and Protein Research. 33: 115-123. PMID 2707968 DOI: 10.1111/J.1399-3011.1989.Tb00196.X |
0.362 |
|
1989 |
O'Brian CA, Fan D, Ward NE, Seid C, Fidler IJ. Level of protein kinase C activity correlates directly with resistance to adriamycin in murine fibrosarcoma cells Febs Letters. 246: 78-82. PMID 2707442 DOI: 10.1016/0014-5793(89)80257-1 |
0.447 |
|
1989 |
O'Brian CA, Ward NE. Biology of the protein kinase C family Cancer and Metastasis Review. 8: 199-214. PMID 2697470 DOI: 10.1007/Bf00047337 |
0.467 |
|
1988 |
Housey GM, Johnson MD, Hsiao WL, O'Brian CA, Murphy JP, Kirschmeier P, Weinstein IB. Overproduction of protein kinase C causes disordered growth control in rat fibroblasts. Cell. 52: 343-54. PMID 3345563 DOI: 10.1016/S0092-8674(88)80027-8 |
0.33 |
|
1988 |
O'brian CA, Ward NE, Anderson BW. Role of specific interactions between protein kinase c and triphenylethylenes in inhibition of the enzyme Journal of the National Cancer Institute. 80: 1628-1633. PMID 3264029 DOI: 10.1093/jnci/80.20.1628 |
0.369 |
|
1988 |
Housey GM, Johnson MD, Hsiao WL, O'Brian CA, Weinstein IB. Structural and functional studies of protein kinase C. Advances in Experimental Medicine and Biology. 234: 127-40. PMID 3063083 |
0.361 |
|
1987 |
Guillem JG, O'Brian CA, Fitzer CJ, Forde KA, LoGerfo P, Treat M, Weinstein IB. Altered levels of protein kinase C and Ca2+-dependent protein kinases in human colon carcinomas. Cancer Research. 47: 2036-9. PMID 3828992 |
0.341 |
|
1987 |
O'Brian CA, Housey GM, Weinstein IB. Binding of protein kinase C to napthalenesulfonamide- and phenothiazine-agarose columns: evidence for direct interactions between protein kinase C and cationic amphiphilic inhibitors of the enzyme. Biochemical Pharmacology. 36: 4179-81. PMID 3689446 DOI: 10.1016/0006-2952(87)90582-X |
0.363 |
|
1987 |
Housey GM, O'Brian CA, Johnson MD, Kirschmeier P, Weinstein IB. Isolation of cDNA clones encoding protein kinase C: evidence for a protein kinase C-related gene family. Proceedings of the National Academy of Sciences of the United States of America. 84: 1065-9. PMID 3469647 DOI: 10.1073/pnas.84.4.1065 |
0.312 |
|
1987 |
O'Brian CA, Weinstein IB. In vitro inhibition of rat brain protein kinase C by rhodamine 6G. Profound effects of the lipid cofactor on the inhibition of the enzyme. Biochemical Pharmacology. 36: 1231-5. PMID 3109437 DOI: 10.1016/0006-2952(87)90075-X |
0.329 |
|
1987 |
O'Brian CA, Arthur WL, Weinstein IB. The activation of protein kinase C by the polyphosphoinositides phosphatidylinositol 4,5-diphosphate and phosphatidylinositol 4-monophosphate. Febs Letters. 214: 339-42. PMID 3032687 DOI: 10.1016/0014-5793(87)80083-2 |
0.383 |
|
1986 |
O'Brian CA, Liskamp RM, Solomon DH, Weinstein IB. Triphenylethylenes: a new class of protein kinase C inhibitors. Journal of the National Cancer Institute. 76: 1243-6. PMID 3458960 DOI: 10.1093/jnci/76.6.1243 |
0.399 |
|
1985 |
Solomon DH, O'Brian CA, Weinstein IB. N-alpha-Tosyl-L-lysine chloromethyl ketone and N-alpha-tosyl-L-phenylalanine chloromethyl ketone inhibit protein kinase C. Febs Letters. 190: 342-4. PMID 4043411 DOI: 10.1016/0014-5793(85)81315-6 |
0.379 |
|
1985 |
O'Brian CA, Liskamp RM, Solomon DH, Weinstein IB. Inhibition of protein kinase C by tamoxifen. Cancer Research. 45: 2462-5. PMID 3157445 |
0.389 |
|
1984 |
Rosevear PR, Fry DC, Mildvan AS, Doughty M, O'Brian C, Kaiser ET. NMR studies of the backbone protons and secondary structure of pentapeptide and heptapeptide substrates bound to bovine heart protein kinase. Biochemistry. 23: 3161-73. PMID 6466636 DOI: 10.1021/Bi00309A009 |
0.368 |
|
1984 |
O'Brian CA, Lawrence DS, Kaiser ET, Weinstein IB. Protein kinase C phosphorylates the synthetic peptide Arg-Arg-Lys-Ala-Ser-Gly-Pro-Pro-Val in the presence of phospholipid plus either Ca2+ or a phorbol ester tumor promoter. Biochemical and Biophysical Research Communications. 124: 296-302. PMID 6238595 DOI: 10.1016/0006-291X(84)90951-3 |
0.418 |
|
1983 |
Mildvan AS, Rosevear PR, Granot J, O'Brian CA, Bramson HN, Kaiser ET. Use of NMR and EPR to study cAMP-dependent protein kinase. Methods in Enzymology. 99: 93-119. PMID 6316105 DOI: 10.1016/0076-6879(83)99045-6 |
0.341 |
|
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