Edwin M. Southern, Ph.D. - Publications

Affiliations: 
University of Edinburgh, Edinburgh, Scotland, United Kingdom 
Area:
DNA organization, chromosome structure

92 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2014 Pirrung MC, Southern EM. The genesis of microarrays. Biochemistry and Molecular Biology Education : a Bimonthly Publication of the International Union of Biochemistry and Molecular Biology. 42: 106-13. PMID 24344052 DOI: 10.1002/bmb.20756  0.92
2008 Ustinov AV, Shmanai VV, Patel K, Stepanova IA, Prokhorenko IA, Astakhova IV, Malakhov AD, Skorobogatyi MV, Bernad PL, Khan S, Shahgholi M, Southern EM, Korshun VA, Shchepinov MS. Reactive trityl derivatives: stabilised carbocation mass-tags for life sciences applications. Organic & Biomolecular Chemistry. 6: 4593-608. PMID 19039369 DOI: 10.1039/b810600b  0.92
2008 Birikh KR, Korshun VA, Bernad PL, Malakhov AD, Milner N, Khan S, Southern EM, Shchepinov MS. Novel mass tags for single nucleotide polymorphism detection. Analytical Chemistry. 80: 2342-50. PMID 17973350 DOI: 10.1021/ac071291y  0.92
2007 Thiery G, Shchepinov MS, Southern EM, Audebourg A, Audard V, Terris B, Gut IG. Multiplex target protein imaging in tissue sections by mass spectrometry--TAMSIM. Rapid Communications in Mass Spectrometry : Rcm. 21: 823-9. PMID 17294518 DOI: 10.1002/rcm.2895  0.92
2007 Appasani K, Southern EM. Bioarrays: From basics to diagnostics Bioarrays: From Basics to Diagnostics. 1-269. DOI: 10.1007/978-1-59745-328-8  0.92
2007 Meuleman WRA, Milner N, Lueerssen DWK, Southern EM. A method for the highly parallel analysis of gene expression of single cells 2007 Nsti Nanotechnology Conference and Trade Show - Nsti Nanotech 2007, Technical Proceedings. 3: 296-299.  0.92
2005 Egeland RD, Southern EM. Electrochemically directed synthesis of oligonucleotides for DNA microarray fabrication. Nucleic Acids Research. 33: e125. PMID 16085751 DOI: 10.1093/nar/gni117  0.92
2005 Bernad PL, Khan S, Korshun VA, Southern EM, Shchepinov MS. S(O)-pixyl protecting group as efficient mass-tag. Chemical Communications (Cambridge, England). 3466-8. PMID 15997299 DOI: 10.1039/b504913j  0.92
2005 Moorcroft MJ, Meuleman WR, Latham SG, Nicholls TJ, Egeland RD, Southern EM. In situ oligonucleotide synthesis on poly(dimethylsiloxane): a flexible substrate for microarray fabrication. Nucleic Acids Research. 33: e75. PMID 15870385 DOI: 10.1093/nar/gni075  0.92
2005 Sohail M, Doran G, Kang S, Akhtar S, Southern EM. Structural rearrangements in RNA on the binding of an antisense oligonucleotide: implications for the study of intra-molecular RNA interactions and the design of cooperatively acting antisense reagents with enhanced efficacy. Journal of Drug Targeting. 13: 61-70. PMID 15848955 DOI: 10.1080/10611860400003825  0.92
2005 Khan S, Bernad PL, Korshun VA, Southern EM, Shchepinov MS. Synthesis of s-pixyl derivatives for mass spectrometric applications Synlett. 2453-2456. DOI: 10.1055/s-2005-872703  0.92
2004 Hussain M, Shchepinov M, Sohail M, Benter IF, Hollins AJ, Southern EM, Akhtar S. A novel anionic dendrimer for improved cellular delivery of antisense oligonucleotides. Journal of Controlled Release : Official Journal of the Controlled Release Society. 99: 139-55. PMID 15342187 DOI: 10.1016/j.jconrel.2004.06.009  0.92
2004 Egeland RD, Southern EM. High resolution electrochemical in situ printing 2004 Nsti Nanotechnology Conference and Trade Show - Nsti Nanotech 2004. 1: 43-49.  0.92
2003 Petch AK, Sohail M, Hughes MD, Benter I, Darling J, Southern EM, Akhtar S. Messenger RNA expression profiling of genes involved in epidermal growth factor receptor signalling in human cancer cells treated with scanning array-designed antisense oligonucleotides. Biochemical Pharmacology. 66: 819-30. PMID 12948863 DOI: 10.1016/S0006-2952(03)00407-6  0.92
2003 Sohail M, Doran G, Riedemann J, Macaulay V, Southern EM. A simple and cost-effective method for producing small interfering RNAs with high efficacy. Nucleic Acids Research. 31: e38. PMID 12655026  0.92
2003 Bohula EA, Salisbury AJ, Sohail M, Playford MP, Riedemann J, Southern EM, Macaulay VM. The efficacy of small interfering RNAs targeted to the type 1 insulin-like growth factor receptor (IGF1R) is influenced by secondary structure in the IGF1R transcript. The Journal of Biological Chemistry. 278: 15991-7. PMID 12604614 DOI: 10.1074/jbc.M300714200  0.92
2002 Egeland RD, Marken F, Southern EM. An electrochemical redox couple activitated by microelectrodes for confined chemical patterning of surfaces. Analytical Chemistry. 74: 1590-6. PMID 12033249 DOI: 10.1021/ac010953v  0.92
2002 Housby JN, Southern EM. Thermus scotoductus and Rhodothermus marinus DNA ligases have higher ligation efficiencies than thermus thermophilus DNA ligase. Analytical Biochemistry. 302: 88-94. PMID 11846380 DOI: 10.1006/abio.2001.5532  0.92
2001 Sohail M, Southern EM. Using oligonucleotide scanning arrays to find effective antisense reagents. Methods in Molecular Biology (Clifton, N.J.). 170: 181-99. PMID 11357682 DOI: 10.1385/1-59259-234-1:181  0.92
2001 Southern EM. DNA microarrays. History and overview. Methods in Molecular Biology (Clifton, N.J.). 170: 1-15. PMID 11357674 DOI: 10.1385/1-59259-234-1:1  0.92
2001 Sohail M, Hochegger H, Klotzbücher A, Guellec RL, Hunt T, Southern EM. Antisense oligonucleotides selected by hybridisation to scanning arrays are effective reagents in vivo. Nucleic Acids Research. 29: 2041-51. PMID 11353073 DOI: 10.1093/NAR/29.10.2041  0.92
2000 Mir KU, Southern EM. Sequence variation in genes and genomic DNA: methods for large-scale analysis. Annual Review of Genomics and Human Genetics. 1: 329-60. PMID 11701633 DOI: 10.1146/annurev.genom.1.1.329  0.92
2000 Sohail M, Southern EM. Hybridization of antisense reagents to RNA. Current Opinion in Molecular Therapeutics. 2: 264-71. PMID 11249620  0.92
2000 Southern EM. Blotting at 25. Trends in Biochemical Sciences. 25: 585-8. PMID 11116181 DOI: 10.1016/S0968-0004(00)01702-3  0.92
2000 Sohail M, Southern EM. Selecting optimal antisense reagents. Advanced Drug Delivery Reviews. 44: 23-34. PMID 11035195 DOI: 10.1016/S0169-409X(00)00081-8  0.92
2000 Nguyen HK, Southern EM. Minimising the secondary structure of DNA targets by incorporation of a modified deoxynucleoside: implications for nucleic acid analysis by hybridisation. Nucleic Acids Research. 28: 3904-9. PMID 11024169  0.92
2000 Sohail M, Southern EM. Antisense arrays. Molecular Cell Biology Research Communications : McBrc. 3: 67-72. PMID 10775501 DOI: 10.1006/mcbr.2000.0178  0.92
2000 Housby JN, Thorbjarnardóttir SH, Jónsson ZO, Southern EM. Optimised ligation of oligonucleotides by thermal ligases: comparison of Thermus scotoductus and Rhodothermus marinus DNA ligases to other thermophilic ligases. Nucleic Acids Research. 28: E10. PMID 10637340  0.92
2000 Shchepinov MS, Chalk R, Southern EM. Trityl tags for encoding in combinatorial synthesis Tetrahedron. 56: 2713-2724. DOI: 10.1016/S0040-4020(00)00223-4  0.92
2000 Shchepinov MS, Korshun VA, Egeland RD, Southern EM. Tritylisation of pyrene, perylene and coronene: A new family of switchable fluorescent labels Tetrahedron Letters. 41: 4943-4948.  0.92
1999 Shchepinov MS, Chalk R, Southern EM. Trityl mass-tags for encoding in combinatorial oligonucleotide synthesis. Nucleic Acids Symposium Series. 107-8. PMID 10780402  0.92
1999 Shchepinov MS, Mir KU, Elder JK, Frank-Kamenetskii MD, Southern EM. Oligonucleotide dendrimers: stable nano-structures. Nucleic Acids Research. 27: 3035-41. PMID 10454597 DOI: 10.1093/nar/27.15.3035  0.92
1999 Mir KU, Southern EM. Determining the influence of structure on hybridization using oligonucleotide arrays. Nature Biotechnology. 17: 788-92. PMID 10429245 DOI: 10.1038/11732  0.92
1999 Sohail M, Akhtar S, Southern EM. The folding of large RNAs studied by hybridization to arrays of complementary oligonucleotides. Rna (New York, N.Y.). 5: 646-55. PMID 10334335 DOI: 10.1017/S1355838299982195  0.92
1999 Southern E, Mir K, Shchepinov M. Molecular interactions on microarrays. Nature Genetics. 21: 5-9. PMID 9915493 DOI: 10.1038/4429  0.44
1998 Housby JN, Southern EM. Fidelity of DNA ligation: a novel experimental approach based on the polymerisation of libraries of oligonucleotides. Nucleic Acids Research. 26: 4259-66. PMID 9722647 DOI: 10.1093/nar/26.18.4259  0.92
1998 Case-Green SC, Mir KU, Pritchard CE, Southern EM. Analysing genetic information with DNA arrays. Current Opinion in Chemical Biology. 2: 404-10. PMID 9691078  0.92
1998 Shchepinov MS, Southern EM. The synthesis of branched oligonucleotide structures Russian Journal of Bioorganic Chemistry. 24: 706-709.  0.92
1997 Southern EM, Milner N, Mir KU. Discovering antisense reagents by hybridization of RNA to oligonucleotide arrays. Ciba Foundation Symposium. 209: 38-44; discussion 44. PMID 9383567  0.92
1997 Shchepinov MS, Udalova IA, Bridgman AJ, Southern EM. Oligonucleotide dendrimers: synthesis and use as polylabelled DNA probes. Nucleic Acids Research. 25: 4447-54. PMID 9358151  0.92
1997 Pritchard CE, Southern EM. Effects of base mismatches on joining of short oligodeoxynucleotides by DNA ligases. Nucleic Acids Research. 25: 3403-7. PMID 9254695 DOI: 10.1093/nar/25.17.3403  0.92
1997 Milner N, Mir KU, Southern EM. Selecting effective antisense reagents on combinatorial oligonucleotide arrays. Nature Biotechnology. 15: 537-41. PMID 9181575 DOI: 10.1038/nbt0697-537  0.92
1997 Shchepinov MS, Case-Green SC, Southern EM. Steric factors influencing hybridisation of nucleic acids to oligonucleotide arrays. Nucleic Acids Research. 25: 1155-61. PMID 9092624 DOI: 10.1093/nar/25.6.1155  0.92
1997 Gray DE, Case-Green SC, Fell TS, Dobson PJ, Southern EM. Ellipsometric and interferometric characterization of DNA probes immobilized on a combinatorial array Langmuir. 13: 2833-2842.  0.92
1996 Southern EM. DNA chips: analysing sequence by hybridization to oligonucleotides on a large scale. Trends in Genetics : Tig. 12: 110-5. PMID 8868349 DOI: 10.1016/0168-9525(96)81422-3  0.92
1996 Southern EM. High-density gridding: techniques and applications. Current Opinion in Biotechnology. 7: 85-8. PMID 8742380 DOI: 10.1016/S0958-1669(96)80100-5  0.92
1995 Southern EM. DNA fingerprinting by hybridisation to oligonucleotide arrays. Electrophoresis. 16: 1539-42. PMID 8582332  0.92
1994 Williams JC, Case-Green SC, Mir KU, Southern EM. Studies of oligonucleotide interactions by hybridisation to arrays: the influence of dangling ends on duplex yield. Nucleic Acids Research. 22: 1365-7. PMID 8190626  0.92
1994 Case-Green SC, Southern EM. Studies on the base pairing properties of deoxyinosine by solid phase hybridisation to oligonucleotides. Nucleic Acids Research. 22: 131-6. PMID 8121796  0.92
1994 Southern EM, Maskos U. Parallel synthesis and analysis of large numbers of related chemical compounds: applications to oligonucleotides. Journal of Biotechnology. 35: 217-27. PMID 7765059 DOI: 10.1016/0168-1656(94)90037-X  0.92
1994 Southern EM, Case-Green SC, Elder JK, Johnson M, Mir KU, Wang L, Williams JC. Arrays of complementary oligonucleotides for analysing the hybridisation behaviour of nucleic acids. Nucleic Acids Research. 22: 1368-73. PMID 7514785 DOI: 10.1093/nar/22.8.1368  0.92
1994 Larin Z, Fricker MD, Maher E, Ishikawa-Brush Y, Southern EM. Fluorescencs in situ hybridisation of multiple probes on a single microscope slide Nucleic Acids Research. 22: 3689-3692.  0.92
1993 Maskos U, Southern EM. A study of oligonucleotide reassociation using large arrays of oligonucleotides synthesised on a glass support. Nucleic Acids Research. 21: 4663-9. PMID 8233815  0.92
1993 Maskos U, Southern EM. A novel method for the parallel analysis of multiple mutations in multiple samples. Nucleic Acids Research. 21: 2269-70. PMID 7684838  0.92
1993 Maskos U, Southern EM. A novel method for the analysis of multiple sequence variants by hybridisation to oligonucleotides. Nucleic Acids Research. 21: 2267-8. PMID 7684837  0.92
1992 Maskos U, Southern EM. Oligonucleotide hybridizations on glass supports: a novel linker for oligonucleotide synthesis and hybridization properties of oligonucleotides synthesised in situ. Nucleic Acids Research. 20: 1679-84. PMID 1579459  0.92
1992 Maskos U, Southern EM. Parallel analysis of oligodeoxyribonucleotide (oligonucleotide) interactions. I. Analysis of factors influencing oligonucleotide duplex formation. Nucleic Acids Research. 20: 1675-8. PMID 1579458  0.92
1992 Southern EM. Genome mapping: cDNA approaches. Current Opinion in Genetics & Development. 2: 412-6. PMID 1504615 DOI: 10.1016/S0959-437X(05)80151-0  0.92
1992 Southern EM. Detection of specific sequences among DNA fragments separated by gel electrophoresis. 1975. Biotechnology (Reading, Mass.). 24: 122-39. PMID 1422006  0.92
1992 Southern EM, Maskos U, Elder JK. Analyzing and comparing nucleic acid sequences by hybridization to arrays of oligonucleotides: evaluation using experimental models. Genomics. 13: 1008-17. PMID 1380482 DOI: 10.1016/0888-7543(92)90014-J  0.92
1988 Anand R, Honeycombe J, Whittaker PA, Elder JK, Southern EM. Clones from an 840-kb fragment containing the 5' region of the DMD locus enriched by pulsed field gel electrophoresis. Genomics. 3: 177-86. PMID 3066744 DOI: 10.1016/0888-7543(88)90077-8  0.92
1988 Southern EM. Prospects for a complete molecular map of the human genome. Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences. 319: 299-307. PMID 2900523  0.92
1988 Whittaker PA, Campbell AJB, Southern EM, Murray NE. Enhanced recovery and restriction mapping of DNA fragments cloned in a new λ vector Nucleic Acids Research. 16: 6725-6736. DOI: 10.1093/nar/16.14.6725  0.92
1987 Southern EM. Analysing DNA in small numbers of cells. Human Reproduction (Oxford, England). 2: 447-50. PMID 3654935  0.92
1987 Southern EM, Anand R, Brown WR, Fletcher DS. A model for the separation of large DNA molecules by crossed field gel electrophoresis. Nucleic Acids Research. 15: 5925-43. PMID 3627974 DOI: 10.1093/nar/15.15.5925  0.92
1986 Elder JK, Green DK, Southern EM. Automatic reading of DNA sequencing gel autoradiographs using a large format digital scanner. Nucleic Acids Research. 14: 417-24. PMID 3753777 DOI: 10.1093/nar/14.1.417  0.92
1986 Whittaker PA, Southern EM. Ultraviolet irradiation of DNA: a way of generating partial digests for rapid restriction site mapping. Gene. 41: 129-34. PMID 3009271 DOI: 10.1016/0378-1119(86)90276-3  0.92
1985 Sealey PG, Whittaker PA, Southern EM. Removal of repeated sequences from hybridisation probes. Nucleic Acids Research. 13: 1905-22. PMID 4000947 DOI: 10.1093/nar/13.6.1905  0.92
1984 Southern EM. DNA sequences and chromosome structure. Journal of Cell Science. Supplement. 1: 31-41. PMID 6397473  0.92
1984 Bhattacharya SS, Wright AF, Clayton JF, Price WH, Phillips CI, McKeown CM, Jay M, Bird AC, Pearson PL, Southern EM. Close genetic linkage between X-linked retinitis pigmentosa and a restriction fragment length polymorphism identified by recombinant DNA probe L1.28. Nature. 309: 253-5. PMID 6325945 DOI: 10.1038/309253a0  0.92
1983 Elder JK, Southern EM. Measurement of DNA length by gel electrophoresis II: Comparison of methods for relating mobility to fragment length. Analytical Biochemistry. 128: 227-31. PMID 6303153 DOI: 10.1016/0003-2697(83)90369-X  0.92
1983 Elder JK, Amos A, Southern EM, Shippey GA. Measurement of DNA length by gel electrophoresis. I. Improved accuracy of mobility measurements using a digital microdensitometer and computer processing. Analytical Biochemistry. 128: 223-6. PMID 6221672 DOI: 10.1016/0003-2697(83)90368-8  0.92
1982 Southern EM. Application of DNA analysis to mapping the human genome. Cytogenetics and Cell Genetics. 32: 52-7. PMID 7140369 DOI: 10.1159/000131686  0.92
1982 Southern EM. Application of DNA analysis to mapping the human genome. Birth Defects Original Article Series. 18: 52-7. PMID 6891612  0.92
1982 Southern EM. New methods for analysing DNA make genetics simpler. Biochemical Society Transactions. 10: 1-4. PMID 6277709  0.92
1979 Southern EM. Measurement of DNA length by gel electrophoresis. Analytical Biochemistry. 100: 319-23. PMID 525781 DOI: 10.1016/0003-2697(79)90235-5  0.92
1979 Southern EM. A preparative gel electrophoresis apparatus for large scale separations. Analytical Biochemistry. 100: 304-18. PMID 525780 DOI: 10.1016/0003-2697(79)90234-3  0.92
1979 Southern EM. Analysis of restriction-fragment patterns from complex deoxyribonucleic acid species. Biochemical Society Symposium. 44: 37-41. PMID 387038  0.92
1978 Bird AP, Southern EM. Use of restriction enzymes to study eukaryotic DNA methylation: I. The methylation pattern in ribosomal DNA from Xenopus laevis. Journal of Molecular Biology. 118: 27-47. PMID 625056 DOI: 10.1016/0022-2836(78)90242-5  0.92
1977 Arnheim N, Southern EM. Heterogeneity of the ribosomal genes in mice and men. Cell. 11: 363-70. PMID 560912 DOI: 10.1016/0092-8674(77)90053-8  0.92
1976 Selsing E, Leslie AG, Arnott S, Gall JG, Skinner DM, Southern EM, Spencer JH, Harbers K. Conformations of satellite DNAs. Nucleic Acids Research. 3: 2451-7. PMID 995639 DOI: 10.1093/nar/3.10.2451  0.92
1975 Southern EM. Detection of specific sequences among DNA fragments separated by gel electrophoresis. Journal of Molecular Biology. 98: 503-17. PMID 1195397 DOI: 10.1016/S0022-2836(75)80083-0  0.92
1975 Southern EM. Long range periodicities in mouse satellite DNA. Journal of Molecular Biology. 94: 51-69. PMID 1142436 DOI: 10.1016/0022-2836(75)90404-0  0.92
1975 Biro PA, Carr-Brown A, Southern EM, Walker PM. Partial sequence analysis of mouse satellite DNA evidence for short range periodicities. Journal of Molecular Biology. 94: 71-86. PMID 806696 DOI: 10.1016/0022-2836(75)90405-2  0.92
1974 Southern EM, Roizes G. The action of a restriction endonuclease on higher organism DNA. Cold Spring Harbor Symposia On Quantitative Biology. 38: 429-33. PMID 4598639  0.92
1974 Southern EM. An improved method for transferring nucleotides from electrophoresis strips to thin layers of ion-exchange cellulose. Analytical Biochemistry. 62: 317-8. PMID 4433052 DOI: 10.1016/0003-2697(74)90395-9  0.92
1973 Ford PJ, Southern EM. Different sequences for 5S RNA in kidney cells and ovaries of Xenopus laevis. Nature: New Biology. 241: 7-12. PMID 4512331  0.92
1971 Southern EM. Effects of sequence divergence on the reassociation properties of repetitive DNAs. Nature: New Biology. 232: 82-3. PMID 5285344  0.92
1971 Southern EM, Mitchell AR. Chromatography of nucleic acid digests on thin layers of cellulose impregnated with polyethyleneimine. The Biochemical Journal. 123: 613-7. PMID 4942451  0.92
1970 Southern EM. Base sequence and evolution of guinea-pig alpha-satellite DNA. Nature. 227: 794-8. PMID 4317352 DOI: 10.1038/227794a0  0.92
1969 Southern EM. Radiation-induced hydrogen isotope exchange in solutions of polyamino acids. Radiation Research. 37: 590-8. PMID 5775543  0.92
1965 Southern EM, Rhodes DN. Radiation-induced optical inversion of L-glutamate residues in poly-alpha,L-glutamic acid. The Biochemical Journal. 97: 14C-16C. PMID 5880014  0.92
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