| Year |
Citation |
Score |
| 1993 |
Kaiser E, Picart F, Kubiak T, Tam JP, Merrifield RB. Selective deprotection of the Nα-tert-butyloxycarbonyl group in solid phase peptide synthesis with chlorotrimethylsilane and phenol Journal of Organic Chemistry. 58: 5167-5175. DOI: 10.1021/Jo00071A028 |
0.353 |
|
| 1993 |
Mihara H, Chmielewski JA, Kaiser ET. Synthesis of the 60 amino acid homeo domain and smaller fragments of the Drosophila gene regulatory protein Antennapedia by a segment synthesis-condensation approach Journal of Organic Chemistry. 58: 2209-2215. DOI: 10.1021/Jo00060A042 |
0.61 |
|
| 1992 |
Butler-Ransohoff JE, Rokita SE, Kendall DA, Banzon JA, Carano KS, Kaiser ET, Matlin AR. Active-site mutagenesis of E. coli alkaline phosphatase: Replacement of serine-102 with nonnucleophilic amino acids Journal of Organic Chemistry. 57: 142-145. DOI: 10.1021/Jo00027A027 |
0.311 |
|
| 1991 |
Tsuji T, Kaiser ET. Design and synthesis of the pseudo-EF hand in calbindin D9K: effect of amino acid substitutions in the alpha-helical regions. Proteins. 9: 12-22. PMID 2017432 DOI: 10.1002/Prot.340090103 |
0.384 |
|
| 1991 |
Sasaki T, Findeis MA, Kaiser ET. Evaluation of the oxime resin based segment synthesis-condensation approach using RNase T1 as a model synthetic target Journal of Organic Chemistry. 56: 3159-3168. DOI: 10.1021/Jo00009A043 |
0.428 |
|
| 1990 |
Sasaki T, Kaiser ET. Synthesis and structural stability of helichrome as an artificial hemeproteins. Biopolymers. 29: 79-88. PMID 2328295 DOI: 10.1002/Bip.360290112 |
0.306 |
|
| 1990 |
Germanas JP, Kaiser ET. Autoxidation of ascorbic acid catalyzed by a semisynthetic enzyme. Biopolymers. 29: 39-43. PMID 2328292 DOI: 10.1002/Bip.360290107 |
0.319 |
|
| 1990 |
Mobashery S, Doughty M, Kaiser ET. Inactivation of the catalytic subunit of bovine cAMP-dependent protein kinase by a peptide-based affinity inactivator. Biopolymers. 29: 131-8. PMID 2328282 DOI: 10.1002/Bip.360290118 |
0.699 |
|
| 1990 |
Mobashery S, Ghosh SS, Tamura SY, Kaiser ET. Design of an effective mechanism-based inactivator for a zinc protease. Proceedings of the National Academy of Sciences of the United States of America. 87: 578-82. PMID 2300547 DOI: 10.1073/Pnas.87.2.578 |
0.529 |
|
| 1990 |
Kendall DA, Doud SK, Kaiser ET. A comparative analysis of single- and multiple-residue substitutions in the alkaline phosphatase signal peptide. Biopolymers. 29: 139-47. PMID 2183883 DOI: 10.1002/Bip.360290119 |
0.388 |
|
| 1990 |
Freimuth PI, Taylor JW, Kaiser ET. Introduction of guest peptides into Escherichia coli alkaline phosphatase. Excision and purification of a dynorphin analogue from an active chimeric protein. The Journal of Biological Chemistry. 265: 896-901. PMID 1967250 |
0.302 |
|
| 1989 |
Kaiser ET, Bock SC. Protein inhibitors of crystal growth. The Journal of Urology. 141: 750-2. PMID 2645434 DOI: 10.1016/S0022-5347(17)41001-9 |
0.321 |
|
| 1989 |
Kaiser ET, Mihara H, Laforet GA, Kelly JW, Walters L, Findeis MA, Sasaki T. Peptide and protein synthesis by segment synthesis-condensation. Science (New York, N.Y.). 243: 187-92. PMID 2492114 DOI: 10.1126/Science.2492114 |
0.575 |
|
| 1989 |
Radziejewski C, Miller WT, Mobashery S, Goldberg AR, Kaiser ET. Purification of recombinant pp60v-src protein tyrosine kinase and phosphorylation of peptides with different secondary structure preference. Biochemistry. 28: 9047-52. PMID 2481500 |
0.613 |
|
| 1989 |
Findeis MA, Kaiser ET. Nitrobenzophenone oxime based resins for the solid-phase synthesis of protected peptide segments Journal of Organic Chemistry. 54: 3478-3482. DOI: 10.1021/Jo00275A041 |
0.306 |
|
| 1989 |
Kaiser ET. Synthetic approaches to biologically active peptides and proteins including enzymes Accounts of Chemical Research. 22: 47-54. |
0.311 |
|
| 1988 |
Mobashery S, Kaiser ET. Identification of amino acid residues involved in substrate recognition by the catalytic subunit of bovine cyclic AMP dependent protein kinase: peptide-based affinity labels. Biochemistry. 27: 3691-6. PMID 3408721 DOI: 10.1021/Bi00410A025 |
0.617 |
|
| 1988 |
Miller WT, Kaiser ET. Probing the peptide binding site of the cAMP-dependent protein kinase by using a peptide-based photoaffinity label. Proceedings of the National Academy of Sciences of the United States of America. 85: 5429-33. PMID 3399499 |
0.516 |
|
| 1988 |
Mihara H, Kaiser ET. A chemically synthesized Antennapedia homeo domain binds to a specific DNA sequence. Science (New York, N.Y.). 242: 925-7. PMID 2903553 DOI: 10.1126/Science.2903553 |
0.366 |
|
| 1988 |
Hilvert D, Hatanaka Y, Kaiser ET. A highly active thermophilic semisynthetic flavoenzyme Journal of the American Chemical Society. 110: 682-689. DOI: 10.1021/Ja00211A004 |
0.488 |
|
| 1988 |
Kaiser E, Tam JP, Kubiak TM, Merrifield RB. Chlorotrimethylsilane-phenol as a mild deprotection reagent for the tert-butyl based protecting groups in peptide synthesis Tetrahedron Letters. 29: 303-306. DOI: 10.1016/S0040-4039(00)80080-5 |
0.4 |
|
| 1988 |
Kaiser ET. Catalytic activity of enzymes altered at their active sites Angewandte Chemie - International Edition in English. 27: 913-922. DOI: 10.1002/Anie.198809131 |
0.396 |
|
| 1987 |
Bramson HN, Thomas NE, Miller WT, Fry DC, Mildvan AS, Kaiser ET. Conformation of Leu-Arg-Arg-Ala-Ser-Leu-Gly bound in the active site of adenosine cyclic 3',5'-phosphate dependent protein kinase. Biochemistry. 26: 4666-70. PMID 3663611 |
0.475 |
|
| 1987 |
Thomas NE, Bramson HN, Miller WT, Kaiser ET. Role of enzyme-peptide substrate backbone hydrogen bonding in determining protein kinase substrate specificities. Biochemistry. 26: 4461-6. PMID 3663600 DOI: 10.1021/Bi00388A041 |
0.535 |
|
| 1987 |
Gardell SJ, Hilvert D, Barnett J, Kaiser ET, Rutter WJ. Use of directed mutagenesis to probe the role of tyrosine 198 in the catalytic mechanism of carboxypeptidase A. The Journal of Biological Chemistry. 262: 576-82. PMID 3542991 |
0.327 |
|
| 1987 |
Kaiser ET. Studies of peptide conformation in the design of peptide agonists. Biochemical Pharmacology. 36: 783-8. PMID 3105536 DOI: 10.1016/0006-2952(87)90162-6 |
0.397 |
|
| 1987 |
Nakatsuka T, Sasaki T, Kaiser ET. Peptide segment synthesis catalyzed by the semisynthetic enzyme thiolsubtilisin Journal of the American Chemical Society. 109: 3808-3810. DOI: 10.1021/Ja00246A064 |
0.423 |
|
| 1987 |
Kaiser ET. Design principles in the construction of biologically active peptides Trends in Biochemical Sciences. 12: 305-309. DOI: 10.1016/0968-0004(87)90147-2 |
0.414 |
|
| 1986 |
Kendall DA, Bock SC, Kaiser ET. Idealization of the hydrophobic segment of the alkaline phosphatase signal peptide. Nature. 321: 706-8. PMID 3520341 DOI: 10.1038/321706A0 |
0.382 |
|
| 1986 |
Ghosh SS, Bock SC, Rokita SE, Kaiser ET. Modification of the active site of alkaline phosphatase by site-directed mutagenesis. Science (New York, N.Y.). 231: 145-8. PMID 3510454 DOI: 10.1126/Science.3510454 |
0.368 |
|
| 1986 |
Khalil A, Bramson N, Kezdy FJ, Kaiser ET, Scanu AM. Affinity of nonhomologous amphiphilic peptides toward a monoclonal antibody raised against apolipoprotein A-I. Proteins. 1: 280-6. PMID 3130624 DOI: 10.1002/Prot.340010311 |
0.355 |
|
| 1986 |
Rajashekhar B, Kaiser ET. Design of biologically active peptides with non-peptidic structural elements. Biological and physical properties of a synthetic analogue of beta-endorphin with unnatural amino acids in the region 6-12. The Journal of Biological Chemistry. 261: 13617-23. PMID 3020038 |
0.323 |
|
| 1986 |
Hilvert D, Gardell SJ, Rutter WJ, Kaiser ET. Evidence against a crucial role for the phenolic hydroxyl of Tyr-248 in peptide and ester hydrolyses catalyzed by carboxypeptidase A: Comparative studies of the pH dependencies of the native and Phe-248-mutant forms Journal of the American Chemical Society. 108: 5298-5304. DOI: 10.1002/Chin.198652064 |
0.587 |
|
| 1986 |
Rokita SE, Kaiser ET. Synthesis and characterization of a new semisynthetic enzyme, flavolysozyme Journal of the American Chemical Society. 108: 4984-4987. DOI: 10.1002/Chin.198650337 |
0.306 |
|
| 1986 |
NAKAGAWA SH, LAU HSH, KEZDY FJ, KAISER ET. ChemInform Abstract: The Use of Polymer-Bound Oximes for the Synthesis of Large Peptides Usable in Segment Condensation: Synthesis of a 44 Amino Acid Amphiphilic Peptide Model (I) of Apolipoprotein A-1. Chemischer Informationsdienst. 17. DOI: 10.1002/chin.198612328 |
0.305 |
|
| 1985 |
Osterman DG, Kaiser ET. Design and characterization of peptides with amphiphilic beta-strand structures. Journal of Cellular Biochemistry. 29: 57-72. PMID 4066779 DOI: 10.1002/Jcb.240290202 |
0.389 |
|
| 1985 |
Bramson HN, Thomas NE, Kaiser ET. The use of N-methylated peptides and depsipeptides to probe the binding of heptapeptide substrates to cAMP-dependent protein kinase. The Journal of Biological Chemistry. 260: 15452-7. PMID 4066678 |
0.367 |
|
| 1985 |
Mildvan AS, Rosevear PR, Fry DC, Bramson HN, Kaiser ET. NMR studies of the mechanism of action and regulation of protein kinase. Current Topics in Cellular Regulation. 27: 133-44. PMID 3004816 DOI: 10.1016/B978-0-12-152827-0.50018-9 |
0.367 |
|
| 1985 |
Kaiser ET, Lawrence DS, Rokita SE. The chemical modification of enzymatic specificity. Annual Review of Biochemistry. 54: 565-95. PMID 2992359 DOI: 10.1146/Annurev.Bi.54.070185.003025 |
0.518 |
|
| 1985 |
Moe GR, Kaiser ET. Design, synthesis, and characterization of a model peptide having potent calcitonin-like biological activity: implications for calcitonin structure/activity. Biochemistry. 24: 1971-6. PMID 2990546 DOI: 10.1021/Bi00329A026 |
0.37 |
|
| 1985 |
Nakagawa SH, Lau HSH, Kezdy FJ, Kaiser ET. The use of polymer-bound oximes for the synthesis of large peptides usable in segment condensation: synthesis of a 44 amino acid amphiphilic peptide model of apolipoprotein A-1 Journal of the American Chemical Society. 107: 7087-7092. DOI: 10.1021/ja00310a055 |
0.303 |
|
| 1985 |
Nakagawa SH, Lau HSH, Kézdy FJ, Kaiser ET. The use of polymer-bound oximes for the synthesis of large peptides usable in segment condensation: Synthesis of a 44 amino acid amphiphilic peptide model of apolipoprotein A-1 Journal of the American Chemical Society. 107: 7087-7092. DOI: 10.1021/Ja00310A055 |
0.414 |
|
| 1985 |
Walters L, Kaiser ET. Design of DNA-binding peptides: stabilization of .alpha.-helical structure by DNA Journal of the American Chemical Society. 107: 6422-6424. DOI: 10.1021/Ja00308A061 |
0.314 |
|
| 1985 |
Hilvert D, Kaiser ET. New semisynthetic flavoenzymes based on a tetrameric protein template, glyceraldehyde-3-phosphate dehydrogenase Journal of the American Chemical Society. 107: 5805-5806. DOI: 10.1021/Ja00306A040 |
0.502 |
|
| 1984 |
Rosevear PR, Fry DC, Mildvan AS, Doughty M, O'Brian C, Kaiser ET. NMR studies of the backbone protons and secondary structure of pentapeptide and heptapeptide substrates bound to bovine heart protein kinase. Biochemistry. 23: 3161-73. PMID 6466636 DOI: 10.1021/Bi00309A009 |
0.556 |
|
| 1984 |
Bramson HN, Kaiser ET, Mildvan AS. Mechanistic studies of cAMP-dependent protein kinase action. Crc Critical Reviews in Biochemistry. 15: 93-124. PMID 6365450 DOI: 10.3109/10409238409102298 |
0.352 |
|
| 1984 |
O'Brian CA, Lawrence DS, Kaiser ET, Weinstein IB. Protein kinase C phosphorylates the synthetic peptide Arg-Arg-Lys-Ala-Ser-Gly-Pro-Pro-Val in the presence of phospholipid plus either Ca2+ or a phorbol ester tumor promoter. Biochemical and Biophysical Research Communications. 124: 296-302. PMID 6238595 DOI: 10.1016/0006-291X(84)90951-3 |
0.497 |
|
| 1984 |
Kaiser ET, Lawrence DS. Chemical mutation of enzyme active sites. Science (New York, N.Y.). 226: 505-11. PMID 6238407 DOI: 10.1126/Science.6238407 |
0.503 |
|
| 1983 |
Nakagawa SH, Kaiser ET. Synthesis of protected peptide segments and their assembly on a polymer-bound oxime: Application to the synthesis of a peptide model for plasma apolipoprotein A-I Journal of Organic Chemistry. 48: 678-685. DOI: 10.1021/Jo00153A012 |
0.381 |
|
| 1983 |
Moe GR, Miller RJ, Kaiser ET. Design of a Peptide Hormone: Synthesis and Characterization of a Model Peptide with Calcitonin-like Activity Journal of the American Chemical Society. 105: 4100-4102. DOI: 10.1021/Ja00350A064 |
0.412 |
|
| 1983 |
Moe GR, Miller RJ, Kaiser ET. Design Of A Peptide Hormone: Synthesis And Characterization Of A Model Peptide With Calcitonin-Like Activity Cheminform. 14. DOI: 10.1002/Chin.198339345 |
0.412 |
|
| 1983 |
DEGRADO WF, KAISER ET. ChemInform Abstract: SOLID-PHASE SYNTHESIS OF PROTECTED PEPTIDES ON A POLYMER-BOUND OXIME: PREPARATION OF SEGMENTS COMPRISING THE SEQUENCE OF A CYTOTOXIC 26-PEPTIDE ANALOG Chemischer Informationsdienst. 14. DOI: 10.1002/chin.198303338 |
0.475 |
|
| 1983 |
Moe GR, Miller RJ, Kaiser ET. Design of a peptide hormone: Synthesis and characterization of a model peptide with calcitonin-like activity Journal of the American Chemical Society. 105: 4100-4102. |
0.301 |
|
| 1982 |
DeGrado WF, Musso GF, Lieber M, Kaiser ET, Kézdy FJ. Kinetics and mechanism of hemolysis induced by melittin and by a synthetic melittin analogue. Biophysical Journal. 37: 329-38. PMID 7055625 DOI: 10.1016/S0006-3495(82)84681-X |
0.482 |
|
| 1982 |
Bramson HN, Thomas N, Matsueda R, Nelson NC, Taylor SS, Kaiser ET. Modification of the catalytic subunit of bovine heart cAMP-dependent protein kinase with affinity labels related to peptide substrates. The Journal of Biological Chemistry. 257: 10575-81. PMID 6286662 |
0.389 |
|
| 1982 |
Taylor JW, Osterman DG, Miller RJ, Kaiser ET. DESIGN AND SYNTHESIS OF A MODEL PEPTIDE WITH β-ENDORPHIN-LIKE PROPERTIES Cheminform. 13. DOI: 10.1002/Chin.198209316 |
0.308 |
|
| 1981 |
Fukushima D, Yokoyama S, Kézdy FJ, Kaiser ET. Binding of amphiphilic peptides to phospholipid/cholesterol unilamellar vesicles: a model for protein--cholesterol interaction. Proceedings of the National Academy of Sciences of the United States of America. 78: 2732-6. PMID 6789321 DOI: 10.1073/Pnas.78.5.2732 |
0.315 |
|
| 1981 |
Taylor JW, Osterman DG, Miller RJ, Kaiser ET. Design and Synthesis of a Model Peptide with β-Endorphin-Like Properties Journal of the American Chemical Society. 103: 6965-6966. DOI: 10.1021/Ja00413A035 |
0.365 |
|
| 1981 |
DeGrado WF, Kézdy FJ, Kaiser ET. Design, synthesis and characterization of a cytotoxic peptide with melittin-like activity Journal of the American Chemical Society. 103: 679-681. DOI: 10.1021/Ja00393A035 |
0.548 |
|
| 1981 |
DeGrado WF, Kezdy FJ, Kaiser ET. Design, synthesis, and characterization of a cytotoxic peptide with melittin-like activity Journal of the American Chemical Society. 103: 679-681. DOI: 10.1021/ja00393a035 |
0.491 |
|
| 1981 |
DEGRADO WF, KEZDY FJ, KAISER ET. ChemInform Abstract: DESIGN, SYNTHESIS, AND CHARACTERIZATION OF A CYTOTOXIC PEPTIDE WITH MELITTIN-LIKE ACTIVITY Chemischer Informationsdienst. 12. DOI: 10.1002/chin.198121334 |
0.492 |
|
| 1980 |
Granot J, Mildvan AS, Kaiser ET. Studies of the mechanism of action and regulation of cAMP-dependent protein kinase. Archives of Biochemistry and Biophysics. 205: 1-17. PMID 6255875 DOI: 10.1016/0003-9861(80)90078-8 |
0.329 |
|
| 1980 |
DeGrado WF, Kaiser ET. Polymer-bound oxime esters as supports for solid-phase peptide synthesis. The preparation of protected peptide fragments The Journal of Organic Chemistry. 45: 1295-1300. DOI: 10.1021/jo01295a026 |
0.481 |
|
| 1980 |
Degrado WF, Kaiser ET. Polymer-bound oxime esters as supports for solid-phase peptide synthesis. Preparation of protected peptide fragments Journal of Organic Chemistry. 45: 1295-1300. DOI: 10.1021/Jo01295A026 |
0.54 |
|
| 1980 |
Bramson HN, Thomas N, DeGrado WF, Kaiser ET. Development of a convenient spectrophotometric assay for peptide phosphorylation catalyzed by adenosine 3',5'-monophosphate dependent protein kinase Journal of the American Chemical Society. 102: 7156-7157. DOI: 10.1021/ja00543a068 |
0.483 |
|
| 1980 |
DEGRADO WF, KAISER ET. ChemInform Abstract: POLYMER-BOUND OXIME ESTERS AS SUPPORTS FOR SOLID-PHASE PEPTIDE SYNTHESIS. THE PREPARATION OF PROTECTED PEPTIDE FRAGMENTS Chemischer Informationsdienst. 11. DOI: 10.1002/chin.198029331 |
0.482 |
|
| 1979 |
Granot J, Kondo H, Armstrong RN, Mildvan AS, Kaiser ET. Nuclear magnetic resonance studies of the conformation of tetraamminecobalt (III)--ATP bound at the active site of bovine heart protein kinase. Biochemistry. 18: 2339-45. PMID 444460 DOI: 10.1021/Bi00578A032 |
0.487 |
|
| 1979 |
Armstrong RN, Kondo H, Granot J, Kaiser ET, Mildvan AS. Magnetic resonance and kinetic studies of the manganese(II) ion and substrate complexes of the catalytic subunit of adenosine 3',5'-monophosphate dependent protein kinase from bovine heart. Biochemistry. 18: 1230-8. PMID 218617 DOI: 10.1021/Bi00574A018 |
0.486 |
|
| 1979 |
Armstrong RN, Kondo H, Kaiser ET. Cyclic AMP-dependent ATPase activity of bovine heart protein kinase. Proceedings of the National Academy of Sciences of the United States of America. 76: 722-5. PMID 218218 DOI: 10.1073/Pnas.76.2.722 |
0.532 |
|
| 1978 |
Armstrong RN, Kaiser ET. Sulfhydryl group reactivity of adenosine 3',5'-monophosphate dependent protein kinase from bovine heart: a probe of holoenzyme structure. Biochemistry. 17: 2840-5. PMID 210783 DOI: 10.1021/Bi00607A022 |
0.495 |
|
| 1978 |
Kroon DJ, Kaiser ET. Studies on the solid-phase synthesis of peptide fragments of apolipoproteins A-I and A-II Journal of Organic Chemistry. 43: 2107-2113. DOI: 10.1021/Jo00405A004 |
0.366 |
|
| 1978 |
Kroon DJ, Kupferberg JP, Kaiser ET, Kézdy FJ. Mechanism of lipid-protein interaction in lipoproteins. A synthetic peptide-lecithin vesicle model [23] Journal of the American Chemical Society. 100: 5975-5977. DOI: 10.1021/Ja00486A078 |
0.345 |
|
| 1976 |
Suh J, Kaiser ET. pH dependence of the nitrotyrosine-248 and arsanilazotyrosine-248 carboxypeptidase A catalyzed hydrolysis of O-(trans-p-chlorocinnamoyl)-L-beta-phenyllactate. Journal of the American Chemical Society. 98: 1940-7. PMID 3540 DOI: 10.1021/Ja00423A048 |
0.462 |
|
| 1976 |
Suh J, Kaiser E. Additions and Corrections - pH Dependence of the Nitrotyrosine-248 and Arsanilazotyrosine-248 Carboxypeptidase A Catalyzed Hydrolysis of O-(trans-p-Chlorocinnamoyl) - L-β-phenyllactate Journal of the American Chemical Society. 98: 4692-4692. DOI: 10.1021/Ja00431A609 |
0.465 |
|
| 1975 |
Suh J, Kaiser ET. Evidence for a difference in mechanism between the reactions with carboxypeptidase A of the (-) and (+) - enantiomers of a thiolester substrate. Biochemical and Biophysical Research Communications. 64: 863-9. PMID 1147968 DOI: 10.1016/0006-291X(75)90127-8 |
0.415 |
|
| 1974 |
Kaiser ET, Chan TW, Suh J. Studies on carboxypeptidase A. Advances in Experimental Medicine and Biology. 48: 59-80. PMID 4429041 |
0.377 |
|
| 1972 |
May SW, Kaiser ET. On the mechanism of the pepsin-catalyzed hydrolysis of sulfite esters. Biochemistry. 11: 592-600. PMID 4334907 DOI: 10.1021/BI00754A018 |
0.516 |
|
| 1970 |
Zaborsky OR, Kaiser ET. Substituent effects in the alkaline hydrolyses of aromatic 5-membered cyclic sulfonates. Hydrolyses of 5-substituted 2-hydroxy-.alpha.-toluenesulfonic acid sultones Journal of the American Chemical Society. 92: 860-862. DOI: 10.1021/Ja00707A021 |
0.302 |
|
| 1967 |
Heidema JH, Kaiser ET. The Chymotrypsin-Catalyzed Hydrolysis of Sultones Journal of the American Chemical Society. 89: 460-461. DOI: 10.1021/Ja00978A057 |
0.339 |
|
| 1966 |
Lo K, Kaiser ET. The esterase activity of bovine erythrocyte carbonic anhydrase. Rapid enzyme-catalysed hydrolysis of 2-hydroxy-5-nitro-α-toluenesulphonic acid sultone Chemical Communications (London). 834-834. DOI: 10.1039/C19660000834 |
0.313 |
|
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