Brian P. Sorrentino - Publications

Affiliations: 
Molecular Therapeutics and Cell Signaling University of Tennessee Health Science Center, Memphis, TN, United States 
Area:
Molecular Biology, Immunology, Epidemiology, Oncology

133 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2021 Bonner MA, Morales-Hernández A, Zhou S, Ma Z, Condori J, Wang YD, Fatima S, Palmer LE, Janke LJ, Fowler S, Sorrentino BP, McKinney-Freeman S. 3' UTR-truncated HMGA2 overexpression induces non-malignant expansion of hematopoietic stem cells in non-human primates. Molecular Therapy. Methods & Clinical Development. 21: 693-701. PMID 34141824 DOI: 10.1016/j.omtm.2021.04.013  0.411
2019 Ozog S, Timberlake ND, Hermann K, Garijo O, Haworth KG, Shi G, Glinkerman CM, Schefter LE, D'Souza S, Simpson E, Sghia-Hughes G, Carillo RR, Boger DL, Kiem HP, Slukvin I, ... ... Sorrentino BP, et al. Resveratrol trimer enhances gene delivery to hematopoietic stem cells by reducing antiviral restriction at endosomes. Blood. PMID 31416800 DOI: 10.1182/Blood.2019000040  0.502
2019 Mamcarz E, Zhou S, Lockey T, Abdelsamed H, Cross SJ, Kang G, Ma Z, Condori J, Dowdy J, Triplett B, Li C, Maron G, Aldave Becerra JC, Church JA, Dokmeci E, ... ... Sorrentino BP, et al. Lentiviral Gene Therapy Combined with Low-Dose Busulfan in Infants with SCID-X1. The New England Journal of Medicine. 380: 1525-1534. PMID 30995372 DOI: 10.1056/Nejmoa1815408  0.473
2018 Fatima S, Zhou S, Sorrentino BP. Marking of definitive HSC precursors in E7.5-E8.5 embryos using an Abcg2-CreER lineage tracing mouse model. Experimental Hematology. PMID 29964089 DOI: 10.1016/J.Exphem.2018.06.286  0.472
2017 Fukuda Y, Wang Y, Lian S, Lynch J, Nagai S, Fanshawe B, Kandilci A, Janke LJ, Neale G, Fan Y, Sorrentino BP, Roussel MF, Grosveld G, Schuetz JD. Upregulated heme biosynthesis, an exploitable vulnerability in MYCN-driven leukemogenesis. Jci Insight. 2. PMID 28768907 DOI: 10.1172/Jci.Insight.92409  0.399
2017 Mamcarz E, Zhou S, Lockey T, Abdelsamed H, Cross S, Ma Z, Dowdy J, Triplett B, Weiss MJ, Ryu BY, Dokmeci E, Aldave JC, Ravin SSD, Youngblood B, Long-Boyle JR, ... ... Sorrentino B, et al. Interim Results from a Phase I/II Clinical Gene Therapy Study for Newly Diagnosed Infants with X-Linked Severe Combined Immunodeficiency Using a Safety-Modified Lentiviral Vector and Targeted Reduced Exposure to Busulfan Blood. 130: 523-523. DOI: 10.1182/Blood.V130.Suppl_1.523.523  0.427
2016 De Ravin SS, Wu X, Moir S, Anaya-O'Brien S, Kwatemaa N, Littel P, Theobald N, Choi U, Su L, Marquesen M, Hilligoss D, Lee J, Buckner CM, Zarember KA, O'Connor G, ... ... Sorrentino BP, et al. Lentiviral hematopoietic stem cell gene therapy for X-linked severe combined immunodeficiency. Science Translational Medicine. 8: 335ra57. PMID 27099176 DOI: 10.1126/Scitranslmed.Aad8856  0.441
2016 Zhou S, Fatima S, Ma Z, Wang YD, Lu T, Janke LJ, Du Y, Sorrentino BP. Evaluating the safety of retroviral vectors based on insertional oncogene activation and blocked differentiation in cultured thymocytes. Molecular Therapy : the Journal of the American Society of Gene Therapy. PMID 26957223 DOI: 10.1038/Mt.2016.55  0.367
2016 Zhou S, Ma Z, Lu T, Brimble MA, Wang Y, Davidoff AM, Sorrentino BP. 571. Safe Harbor Targeting of IL2RG Expression Cassettes for Gene Therapy of X-Linked Severe Combined Immunodeficiency (SCID-X1) Molecular Therapy. 24: S228. DOI: 10.1016/S1525-0016(16)33379-2  0.488
2016 Bonner MA, Zhou S, Wang Y, Ma Z, Palmer L, Sorrentino BP. 281. Enforced Expression of a Mutant HMGA2 Gene Leads to Competitive Expansion and High Level Marking of Long-Term Hematopoietic Stem Cells in Transplanted Nemestrina Macaques Molecular Therapy. 24: S112-S113. DOI: 10.1016/S1525-0016(16)33090-8  0.557
2015 Doyle MJ, Maher TJ, Li Q, Garry M, Sorrentino BP, Martin CM. Abcg2 labeled cells contribute to different cell populations in the embryonic and adult heart. Stem Cells and Development. PMID 26573225 DOI: 10.1089/Scd.2015.0272  0.391
2015 Morfouace M, Cheepala S, Jackson S, Fukuda Y, Patel YT, Fatima S, Kawauchi D, Shelat AA, Stewart CF, Sorrentino BP, Schuetz JD, Roussel MF. ABCG2 Transporter Expression Impacts Group 3 Medulloblastoma Response to Chemotherapy. Cancer Research. PMID 26199091 DOI: 10.1158/0008-5472.Can-15-0030  0.338
2015 Felsburg PJ, De Ravin SS, Malech HL, Sorrentino BP, Burtner C, Kiem HP. Gene therapy studies in a canine model of X-linked severe combined immunodeficiency. Human Gene Therapy. Clinical Development. 26: 50-6. PMID 25603151 DOI: 10.1089/humc.2015.004  0.409
2015 Zhou S, Bonner MA, Wang YD, Rapp S, De Ravin SS, Malech HL, Sorrentino BP. Quantitative shearing linear amplification polymerase chain reaction: an improved method for quantifying lentiviral vector insertion sites in transplanted hematopoietic cell systems. Human Gene Therapy Methods. 26: 4-12. PMID 25545666 DOI: 10.1089/hgtb.2014.122  0.312
2015 De Ravin SS, Wu X, Theobald N, Lee JS, Gray J, Hanson IC, Notarangelo L, Sorrentino BP, Malech HL. Lentiviral Hematopoietic Stem Cell Gene Therapy for Older Patients with X-Linked Severe Combined Immunodeficiency Blood. 126: 261-261. DOI: 10.1182/Blood.V126.23.261.261  0.514
2015 Choi U, Theobald N, Robert TE, Gray J, Rawlings DJ, Sorrentino BP, Malech H, De Ravin SS. High Titer Lentivector from a Stable Lenti-Producer Efficiently Corrects CD34+ Hematopoietic Stem Cells from Patients with p47phox-Deficient Chronic Granulomatous Disease Blood. 126: 2036-2036. DOI: 10.1182/Blood.V126.23.2036.2036  0.488
2015 Maciaszek JL, Treanor LM, Sorrentino BP. 445. A Delectable Lentiviral Vector System for Testing Oncogene Addiction in Hematological Malignancies Molecular Therapy. 23: S176-S177. DOI: 10.1016/S1525-0016(16)34054-0  0.528
2015 Fatima S, Zhou S, Wang Y, Ma Z, Du Y, Finkelstein D, Sorrentino BP. 291. A Novel Safety Assay for Retroviral Vectors That Reproduces Lmo2 Proto-Oncogene Insertional Activation Events Molecular Therapy. 23: S117. DOI: 10.1016/S1525-0016(16)33900-4  0.482
2015 Bonner M, Ma Z, Zhou S, Ren A, Chandrasekaran A, Gray JT, Sorrentino BP, Throm RE. 81. Development of a Second Generation Stable Lentiviral Packaging Cell Line in Support of Clinical Gene Transfer Protocols Molecular Therapy. 23: S35. DOI: 10.1016/S1525-0016(16)33686-3  0.43
2014 Yu H, Neale G, Zhang H, Lee HM, Ma Z, Zhou S, Forget BG, Sorrentino BP. Downregulation of Prdm16 mRNA is a specific antileukemic mechanism during HOXB4-mediated HSC expansion in vivo. Blood. 124: 1737-47. PMID 25082879 DOI: 10.1182/Blood-2013-10-534735  0.498
2014 Maher TJ, Ren Y, Li Q, Braunlin E, Garry MG, Sorrentino BP, Martin CM. ATP-binding cassette transporter Abcg2 lineage contributes to the cardiac vasculature after oxidative stress. American Journal of Physiology. Heart and Circulatory Physiology. 306: H1610-8. PMID 24727496 DOI: 10.1152/Ajpheart.00638.2013  0.32
2014 Treanor LM, Zhou S, Janke L, Churchman ML, Ma Z, Lu T, Chen SC, Mullighan CG, Sorrentino BP. Interleukin-7 receptor mutants initiate early T cell precursor leukemia in murine thymocyte progenitors with multipotent potential. The Journal of Experimental Medicine. 211: 701-13. PMID 24687960 DOI: 10.1084/Jem.20122727  0.436
2014 De Ravin SS, Gray JT, Throm RE, Spindler J, Kearney M, Wu X, Coffin JM, Hughes SH, Malderelli F, Sorrentino BP, Malech HL. False-positive HIV PCR test following ex vivo lentiviral gene transfer treatment of X-linked severe combined immunodeficiency vector. Molecular Therapy : the Journal of the American Society of Gene Therapy. 22: 244-5. PMID 24487563 DOI: 10.1038/Mt.2013.296  0.308
2013 Koldej RM, Carney G, Wielgosz MM, Zhou S, Zhan J, Sorrentino BP, Nienhuis AW. Comparison of insulators and promoters for expression of the Wiskott-Aldrich syndrome protein using lentiviral vectors. Human Gene Therapy. Clinical Development. 24: 77-85. PMID 23786330 DOI: 10.1089/Humc.2012.244  0.495
2013 Zhou S, Ma Z, Lu T, Janke L, Gray JT, Sorrentino BP. Mouse transplant models for evaluating the oncogenic risk of a self-inactivating XSCID lentiviral vector. Plos One. 8: e62333. PMID 23626802 DOI: 10.1371/Journal.Pone.0062333  0.492
2013 O'Reilly M, Kohn DB, Bartlett J, Benson J, Brooks PJ, Byrne BJ, Camozzi C, Cornetta K, Crystal RG, Fong Y, Gargiulo L, Gopal-Srivastava R, High KA, Jacobson SG, Jambou RC, ... ... Sorrentino B, et al. Gene therapy for rare diseases: summary of a National Institutes of Health workshop, September 13, 2012. Human Gene Therapy. 24: 355-62. PMID 23517518 DOI: 10.1089/Hum.2013.064  0.303
2013 Yasuda K, Cline C, Vogel P, Onciu M, Fatima S, Sorrentino BP, Thirumaran RK, Ekins S, Urade Y, Fujimori K, Schuetz EG. Drug transporters on arachnoid barrier cells contribute to the blood-cerebrospinal fluid barrier. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 41: 923-31. PMID 23298861 DOI: 10.1124/Dmd.112.050344  0.37
2013 Treanor LM, Zhou S, Fukuda Y, Satish N, Finkelstein D, Schuetz JD, Mullighan CG, Sorrentino BP. N-Myc Is Overexpressed In Both Murine and Human Early T-Cell Precursor Leukemia and Is Sufficient To Initiate this Leukemia In Multipotent Primitive Arf-/- thymocytes Blood. 122: 348-348. DOI: 10.1182/Blood.V122.21.348.348  0.491
2012 Greene MR, Lockey T, Mehta PK, Kim YS, Eldridge PW, Gray JT, Sorrentino BP. Transduction of human CD34+ repopulating cells with a self-inactivating lentiviral vector for SCID-X1 produced at clinical scale by a stable cell line. Human Gene Therapy Methods. 23: 297-308. PMID 23075105 DOI: 10.1089/Hgtb.2012.150  0.453
2012 Sorrentino BP. Chemoprotection in brain tumor patients: another success for stem cell gene therapy. Molecular Therapy : the Journal of the American Society of Gene Therapy. 20: 1485-7. PMID 22850719 DOI: 10.1038/Mt.2012.139  0.436
2012 Corrigan-Curay J, Cohen-Haguenauer O, O'Reilly M, Ross SR, Fan H, Rosenberg N, Somia N, King N, Friedmann T, Dunbar C, Aiuti A, Naldini L, Baum C, von Kalle C, Kiem HP, ... ... Sorrentino BP, et al. Challenges in vector and trial design using retroviral vectors for long-term gene correction in hematopoietic stem cell gene therapy. Molecular Therapy : the Journal of the American Society of Gene Therapy. 20: 1084-94. PMID 22652996 DOI: 10.1038/Mt.2012.93  0.366
2012 Fatima S, Zhou S, Sorrentino BP. Abcg2 expression marks tissue-specific stem cells in multiple organs in a mouse progeny tracking model. Stem Cells (Dayton, Ohio). 30: 210-21. PMID 22134889 DOI: 10.1002/Stem.1002  0.52
2011 Campbell PK, Zong Y, Yang S, Zhou S, Rubnitz JE, Sorrentino BP. Identification of a novel, tissue-specific ABCG2 promoter expressed in pediatric acute megakaryoblastic leukemia. Leukemia Research. 35: 1321-9. PMID 21640380 DOI: 10.1016/J.Leukres.2011.05.004  0.56
2011 Treanor LM, Volanakis EJ, Zhou S, Lu T, Sherr CJ, Sorrentino BP. Functional interactions between Lmo2, the Arf tumor suppressor, and Notch1 in murine T-cell malignancies. Blood. 117: 5453-62. PMID 21427293 DOI: 10.1182/Blood-2010-09-309831  0.361
2011 Jun D, Garat C, West J, Thorn N, Chow K, Cleaver T, Sullivan T, Torchia EC, Childs C, Shade T, Tadjali M, Lara A, Nozik-Grayck E, Malkoski S, Sorrentino B, et al. The pathology of bleomycin-induced fibrosis is associated with loss of resident lung mesenchymal stem cells that regulate effector T-cell proliferation. Stem Cells (Dayton, Ohio). 29: 725-35. PMID 21312316 DOI: 10.1002/Stem.604  0.376
2011 Greene MR, Lockey T, Gray JT, Eldridge PW, Kim Y, Mehta PK, Sorrentino BP. Transduction of Human CD34+ Derived NSG Repopulating Cells with An Insulated SIN Lentiviral Vector for SCID-X1 From a Stable Producer Cell Line At Clinical Scale Blood. 118: 670-670. DOI: 10.1182/Blood.V118.21.670.670  0.456
2011 Treanor LM, Zhou S, Lu T, Mullighan CG, Sorrentino BP. Lmo2 Overexpression and Arf Loss Induce Myeloid Differentiation in Primitive Thymocytes Blood. 118: 47-47. DOI: 10.1182/Blood.V118.21.47.47  0.526
2011 Yu H, Zhou S, Neale GA, Sorrentino BP. Gene Expression Profiling of Murine HOXB4-Transduced HSCs Shows Multiple Counter-Regulatory Signals That May Control HSC Pool Size Blood. 118: 2361-2361. DOI: 10.1182/Blood.V118.21.2361.2361  0.511
2011 Zhou S, Fatima S, Sorrentino BP. Marking of Embryonic Precursors of Adult Hematopoietic Stem Cells At Gestational Day E7.5-E8.5 Using An Abcg2-CreERT2 Lineage Tracing Mouse Model Blood. 118: 1287-1287. DOI: 10.1182/Blood.V118.21.1287.1287  0.45
2010 Zhou S, Mody D, DeRavin SS, Hauer J, Lu T, Ma Z, Hacein-Bey Abina S, Gray JT, Greene MR, Cavazzana-Calvo M, Malech HL, Sorrentino BP. A self-inactivating lentiviral vector for SCID-X1 gene therapy that does not activate LMO2 expression in human T cells. Blood. 116: 900-8. PMID 20457870 DOI: 10.1182/Blood-2009-10-250209  0.442
2010 Sorrentino B. Assessing the risk of T-cell malignancies in mouse models of SCID-X1. Molecular Therapy : the Journal of the American Society of Gene Therapy. 18: 868-70. PMID 20436493 DOI: 10.1038/Mt.2010.69  0.498
2010 Jiang J, Yu H, Shou Y, Neale G, Zhou S, Lu T, Sorrentino BP. Hemgn is a direct transcriptional target of HOXB4 and induces expansion of murine myeloid progenitor cells. Blood. 116: 711-9. PMID 20393131 DOI: 10.1182/Blood-2009-07-235341  0.479
2010 Sorrentino BP. Scl and stem cell quiescence. Blood. 115: 751-2. PMID 20110428 DOI: 10.1182/Blood-2009-11-251264  0.412
2010 Treanor LM, Zhou S, Lu T, Sorrentino BP. Loss of p19Arf Increases the Self-Renewal Capacity of Immature Thymocytes That Over-Express LMO2 Blood. 116: 4198-4198. DOI: 10.1182/Blood.V116.21.4198.4198  0.491
2009 Larochelle A, Choi U, Shou Y, Naumann N, Loktionova NA, Clevenger JR, Krouse A, Metzger M, Donahue RE, Kang E, Stewart C, Persons D, Malech HL, Dunbar CE, Sorrentino BP. In vivo selection of hematopoietic progenitor cells and temozolomide dose intensification in rhesus macaques through lentiviral transduction with a drug resistance gene. The Journal of Clinical Investigation. 119: 1952-63. PMID 19509470 DOI: 10.1172/Jci37506  0.516
2009 Cicero SA, Johnson D, Reyntjens S, Frase S, Connell S, Chow LM, Baker SJ, Sorrentino BP, Dyer MA. Cells previously identified as retinal stem cells are pigmented ciliary epithelial cells. Proceedings of the National Academy of Sciences of the United States of America. 106: 6685-90. PMID 19346468 DOI: 10.1073/Pnas.0901596106  0.439
2009 Throm RE, Ouma AA, Zhou S, Chandrasekaran A, Lockey T, Greene M, De Ravin SS, Moayeri M, Malech HL, Sorrentino BP, Gray JT. Efficient construction of producer cell lines for a SIN lentiviral vector for SCID-X1 gene therapy by concatemeric array transfection. Blood. 113: 5104-10. PMID 19286997 DOI: 10.1182/Blood-2008-11-191049  0.437
2007 Will E, Bailey J, Schuesler T, Modlich U, Balcik B, Burzynski B, Witte D, Layh-Schmitt G, Rudolph C, Schlegelberger B, von Kalle C, Baum C, Sorrentino BP, Wagner LM, Kelly P, et al. Importance of murine study design for testing toxicity of retroviral vectors in support of phase I trials. Molecular Therapy : the Journal of the American Society of Gene Therapy. 15: 782-91. PMID 17299409 DOI: 10.1038/Sj.Mt.6300083  0.478
2007 Zong Y, Zhou S, Sorrentino BP. Reply to 'Resistance reversal by RNAi silencing of MDR1 in CML cells associated with increase in imatinib intracellular levels' by Widmer et al. [2] Leukemia. 21: 1562-1563. DOI: 10.1038/Sj.Leu.2404672  0.532
2006 Thrasher AJ, Gaspar HB, Baum C, Modlich U, Schambach A, Candotti F, Otsu M, Sorrentino B, Scobie L, Cameron E, Blyth K, Neil J, Abina SH, Cavazzana-Calvo M, Fischer A. Gene therapy: X-SCID transgene leukaemogenicity. Nature. 443: E5-6; discussion E6-. PMID 16988659 DOI: 10.1038/Nature05219  0.385
2006 Zong Y, Zhou S, Fatima S, Sorrentino BP. Expression of mouse Abcg2 mRNA during hematopoiesis is regulated by alternative use of multiple leader exons and promoters. The Journal of Biological Chemistry. 281: 29625-32. PMID 16885162 DOI: 10.1074/Jbc.M606314200  0.631
2006 Shou Y, Ma Z, Lu T, Sorrentino BP. Unique risk factors for insertional mutagenesis in a mouse model of XSCID gene therapy. Proceedings of the National Academy of Sciences of the United States of America. 103: 11730-5. PMID 16864781 DOI: 10.1073/Pnas.0603635103  0.424
2006 Leggas M, Panetta JC, Zhuang Y, Schuetz JD, Johnston B, Bai F, Sorrentino B, Zhou S, Houghton PJ, Stewart CF. Gefitinib modulates the function of multiple ATP-binding cassette transporters in vivo. Cancer Research. 66: 4802-7. PMID 16651435 DOI: 10.1158/0008-5472.Can-05-2915  0.313
2006 Nienhuis AW, Dunbar CE, Sorrentino BP. Genotoxicity of retroviral integration in hematopoietic cells. Molecular Therapy : the Journal of the American Society of Gene Therapy. 13: 1031-49. PMID 16624621 DOI: 10.1016/J.Ymthe.2006.03.001  0.463
2006 Tadjali M, Zhou S, Rehg J, Sorrentino BP. Prospective isolation of murine hematopoietic stem cells by expression of an Abcg2/GFP allele. Stem Cells (Dayton, Ohio). 24: 1556-63. PMID 16484343 DOI: 10.1634/stemcells.2005-0562  0.422
2006 Seggewiss R, Pittaluga S, Adler RL, Guenaga FJ, Ferguson C, Pilz IH, Ryu B, Sorrentino BP, Young WS, Donahue RE, von Kalle C, Nienhuis AW, Dunbar CE. Acute myeloid leukemia is associated with retroviral gene transfer to hematopoietic progenitor cells in a rhesus macaque. Blood. 107: 3865-7. PMID 16439674 DOI: 10.1182/Blood-2005-10-4108  0.519
2006 Zong Y, Zhou S, Sorrentino BP. Reply to Rumpold et al. Leukemia. 20: 144-145. PMID 16270041 DOI: 10.1038/Sj.Leu.2404002  0.454
2006 Stepanova L, Sorrentino B. “Side Population” Cells in Mouse Neuroblastoma Express Abcg2 and Are Enriched for Neuroblastoma Stem Cells. Blood. 108: 4268-4268. DOI: 10.1182/Blood.V108.11.4268.4268  0.447
2006 Jiang J, Shou Y, Sorrentino BP. Identifying Direct Targets of the Hoxb4 Transcription Factor Involved in Hematopoietic Cell Self Renewal. Blood. 108: 4190-4190. DOI: 10.1182/blood.v108.11.4190.4190  0.386
2006 Shou Y, Gray J, Agricola BA, Ma Z, Persons DA, Sorrentino BP. Retroviral Vector Integration Site Analysis in Rhesus Macaques Transplanted with Hematopoietic Stem Cells Transduced with Simian Immunodeficiency Virus Vectors. Blood. 108: 3255-3255. DOI: 10.1182/Blood.V108.11.3255.3255  0.398
2006 Zhou S, Fatima S, Sorrentino BP. Abcg2 Expression Marks Neural Stem Cells in the Murine Cerebellum. Blood. 108: 1674-1674. DOI: 10.1182/Blood.V108.11.1674.1674  0.501
2006 Tadjali M, Zhou S, Sorrentino BP. Expression of Abcg2 in Murine Skeletal Muscle Cells Identifies Two Populations with Different Myogenic Potential. Blood. 108: 1669-1669. DOI: 10.1182/Blood.V108.11.1669.1669  0.465
2006 Will E, Bailey J, Schuesler T, Balcik B, Burzynski B, Witte D, Layh-Schmitt G, vonKalle C, Baum C, Sorrentino BP, Wagner LM, Reeves L, Williams DA. 459. Murine Study To Evaluate Long-Term Transgene Expression of the MSCV-MGMTP140K wc Retroviral Vector in Support of a Phase I Gene Transfer Trial-Limitations of the Murine Model as a Pre-Clinical Tool Molecular Therapy. 13: S177-S178. DOI: 10.1016/J.Ymthe.2006.08.528  0.442
2006 Shou Y, Gray J, Agricola B, Ma Z, Nair GK, Stewart CF, Persons DA, Sorrentino BP. 69. Selection of Hematopoietic Progenitor and Stem Cells in Transplanted Rhesus Macaques Using MGMT and HOXB4 Lentiviral Vectors Molecular Therapy. 13: S29. DOI: 10.1016/J.Ymthe.2006.08.085  0.491
2005 Zong Y, Zhou S, Sorrentino BP. Loss of P-glycoprotein expression in hematopoietic stem cells does not improve responses to imatinib in a murine model of chronic myelogenous leukemia. Leukemia. 19: 1590-6. PMID 16001089 DOI: 10.1038/Sj.Leu.2403853  0.609
2005 Stepanova L, Sorrentino BP. A limited role for p16Ink4a and p19Arf in the loss of hematopoietic stem cells during proliferative stress. Blood. 106: 827-32. PMID 15692066 DOI: 10.1182/Blood-2004-06-2242  0.487
2005 McGaha TL, Sorrentino B, Ravetch JV. Restoration of tolerance in lupus by targeted inhibitory receptor expression. Science (New York, N.Y.). 307: 590-3. PMID 15681388 DOI: 10.1126/Science.1105160  0.356
2005 Zhou S, Zong Y, Ney PA, Nair G, Stewart CF, Sorrentino BP. Increased expression of the Abcg2 transporter during erythroid maturation plays a role in decreasing cellular protoporphyrin IX levels. Blood. 105: 2571-6. PMID 15546952 DOI: 10.1182/Blood-2004-04-1566  0.615
2005 Zong Y, Zhou S, Sorrentino BP. Lineage-Specific Expression of Mouse Abcg2 during Hematopoiesis Is Regulated by Alternative Use of Multiple Leader Exons and Promoters. Blood. 106: 4251-4251. DOI: 10.1182/blood.v106.11.4251.4251  0.599
2005 Shou Y, Stepanova L, Sorrentino BP. An Accelerated Incidence of T-Cell Malignancies in a Mouse Model of XSCID Gene Therapy Is Associated with an Expanded Progenitor Cell Pool in the Bone Marrow. Blood. 106: 197-197. DOI: 10.1182/Blood.V106.11.197.197  0.509
2005 Tadjali M, Zhou S, Rehg J, Sorrentino BP. Relationship between ABCG2 Expression and Side Population Stem Cell Phenotype in Murine Hematopoietic System Revealed by an Abcg2/GFP Knock-In Mouse Model. Blood. 106: 1716-1716. DOI: 10.1182/Blood.V106.11.1716.1716  0.484
2005 Sorrentino BP. Improved human stem-cell transaction: The cat's meow Blood. 106: 8. DOI: 10.1182/Blood-2005-04-1498  0.433
2005 Shou Y, Gray J, Agricola B, Ma Z, Persons DP, Sorrentino BP. 1030. A Rhesus Macaque Transplant Model for Drug Selection of Hematopoietic Stem Cells Transduced with MGMT Vectors Molecular Therapy. 11. DOI: 10.1016/J.Ymthe.2005.07.577  0.505
2005 Shou Y, Stepanova L, Sorrentino BP. 454. Mouse Models for the Analysis of Genetic Risk Factors for Hematopoietic Transformation in XSCID Gene Therapy Molecular Therapy. 11. DOI: 10.1016/J.Ymthe.2005.06.462  0.493
2005 Seggewiss R, Pittaluga S, Adler R, Ferguson C, Vanin EF, Kelly PF, Donahue RE, Sorrentino BP, Nienhuis AW, Dunbar CE. 387. Myeloid Sarcoma Associated with Gene Marking of Hematopoietic Stem Cells in a Rhesus Macaque Molecular Therapy. 11. DOI: 10.1016/J.Ymthe.2005.06.390  0.486
2004 Sorrentino BP. Clinical strategies for expansion of haematopoietic stem cells. Nature Reviews. Immunology. 4: 878-88. PMID 15516967 DOI: 10.1038/Nri1487  0.421
2004 Krishnamurthy P, Ross DD, Nakanishi T, Bailey-Dell K, Zhou S, Mercer KE, Sarkadi B, Sorrentino BP, Schuetz JD. The stem cell marker Bcrp/ABCG2 enhances hypoxic cell survival through interactions with heme. The Journal of Biological Chemistry. 279: 24218-25. PMID 15044468 DOI: 10.1074/Jbc.M313599200  0.479
2004 Kiem HP, Sellers S, Thomasson B, Morris JC, Tisdale JF, Horn PA, Hematti P, Adler R, Kuramoto K, Calmels B, Bonifacino A, Hu J, von Kalle C, Schmidt M, Sorrentino B, et al. Long-term clinical and molecular follow-up of large animals receiving retrovirally transduced stem and progenitor cells: no progression to clonal hematopoiesis or leukemia. Molecular Therapy : the Journal of the American Society of Gene Therapy. 9: 389-95. PMID 15006605 DOI: 10.1016/J.Ymthe.2003.12.006  0.497
2004 Persons DA, Allay JA, Bonifacino A, Lu T, Agricola B, Metzger ME, Donahue RE, Dunbar CE, Sorrentino BP. Transient in vivo selection of transduced peripheral blood cells using antifolate drug selection in rhesus macaques that received transplants with hematopoietic stem cells expressing dihydrofolate reductase vectors. Blood. 103: 796-803. PMID 12920024 DOI: 10.1182/Blood-2003-05-1572  0.504
2004 Tadjali M, Zhou S, Rehg J, Sorrentino BP. ABCG2 Expression as Prospective Marker for Hematopoeitic Stem Cell Purification. Blood. 104: 3212-3212. DOI: 10.1182/Blood.V104.11.3212.3212  0.534
2004 Stepanova L, Sorrentino BP. Expression of a HoxC4 Retroviral Vector Mediates Expansion of Murine Hematopoietic Stem Cells with Normal Hematopoiesis in Transplanted Mice. Blood. 104: 2788-2788. DOI: 10.1182/Blood.V104.11.2788.2788  0.554
2004 Shou Y, Stepanova L, Sorrentino B. Pharmacologic Control of HOXB4-Mediated Expansion of Murine Hematopoietic Stem Cells; Evidence for a Restricted Time Interval for Expansion. Blood. 104: 1689-1689. DOI: 10.1182/Blood.V104.11.1689.1689  0.455
2004 Sorrentino BP. One step closer to gene therapy for hemoglobinopathies Blood. 104: 3419-3419. DOI: 10.1182/Blood-2004-09-3516  0.345
2004 Stepanova L, Sorrentino BP. 634. The Role of Ink4a-Arf Locus in Control of Hematopoietic Stem Cell Proliferation Molecular Therapy. 9. DOI: 10.1016/J.Ymthe.2004.06.567  0.498
2004 Shou Y, Stepanova L, Sorrentino BP. 630. Tamoxifen-Inducible Expansion of Murine Hematopoietic Stem Cells by Retroviral-Mediated Transfer of a HOXB4-ERT2 Fusion Protein Molecular Therapy. 9. DOI: 10.1016/J.Ymthe.2004.06.560  0.527
2003 Zhou S, Zong Y, Lu T, Sorrentino BP. Hematopoietic cells from mice that are deficient in both Bcrp1/Abcg2 and Mdr1a/1b develop normally but are sensitized to mitoxantrone. Biotechniques. 35: 1248-52. PMID 14682060 DOI: 10.2144/03356Ss04  0.596
2003 Sawai N, Persons DA, Zhou S, Lu T, Sorrentino BP. Reduction in hematopoietic stem cell numbers with in vivo drug selection can be partially abrogated by HOXB4 gene expression. Molecular Therapy : the Journal of the American Society of Gene Therapy. 8: 376-84. PMID 12946310 DOI: 10.1016/S1525-0016(03)00205-3  0.483
2003 Kohn DB, Sadelain M, Dunbar C, Bodine D, Kiem HP, Candotti F, Tisdale J, Riviére I, Blau CA, Richard RE, Sorrentino B, Nolta J, Malech H, Brenner M, Cornetta K, et al. American Society of Gene Therapy (ASGT) ad hoc subcommittee on retroviral-mediated gene transfer to hematopoietic stem cells. Molecular Therapy : the Journal of the American Society of Gene Therapy. 8: 180-7. PMID 12907140 DOI: 10.1016/S1525-0016(03)00212-0  0.441
2003 Nienhuis AW, Hanawa H, Sawai N, Sorrentino BP, Persons DA. Development of gene therapy for hemoglobin disorders. Annals of the New York Academy of Sciences. 996: 101-11. PMID 12799288 DOI: 10.1111/J.1749-6632.2003.Tb03238.X  0.496
2003 Persons DA, Allay ER, Sawai N, Hargrove PW, Brent TP, Hanawa H, Nienhuis AW, Sorrentino BP. Successful treatment of murine beta-thalassemia using in vivo selection of genetically modified, drug-resistant hematopoietic stem cells. Blood. 102: 506-13. PMID 12663444 DOI: 10.1182/Blood-2003-03-0677  0.5
2002 Abbott BL, Colapietro AM, Barnes Y, Marini F, Andreeff M, Sorrentino BP. Low levels of ABCG2 expression in adult AML blast samples. Blood. 100: 4594-601. PMID 12393637 DOI: 10.1182/Blood-2002-01-0271  0.316
2002 Zhou S, Morris JJ, Barnes Y, Lan L, Schuetz JD, Sorrentino BP. Bcrp1 gene expression is required for normal numbers of side population stem cells in mice, and confers relative protection to mitoxantrone in hematopoietic cells in vivo. Proceedings of the National Academy of Sciences of the United States of America. 99: 12339-44. PMID 12218177 DOI: 10.1073/Pnas.192276999  0.534
2002 Sorrentino BP. Gene therapy to protect haematopoietic cells from cytotoxic cancer drugs. Nature Reviews. Cancer. 2: 431-41. PMID 12189385 DOI: 10.1038/Nrc823  0.45
2002 Bunting KD, Bradley HL, Hawley TS, Moriggl R, Sorrentino BP, Ihle JN. Reduced lymphomyeloid repopulating activity from adult bone marrow and fetal liver of mice lacking expression of STAT5. Blood. 99: 479-87. PMID 11781228 DOI: 10.1182/Blood.V99.2.479  0.488
2001 Zhou S, Schuetz JD, Bunting KD, Colapietro AM, Sampath J, Morris JJ, Lagutina I, Grosveld GC, Osawa M, Nakauchi H, Sorrentino BP. The ABC transporter Bcrp1/ABCG2 is expressed in a wide variety of stem cells and is a molecular determinant of the side-population phenotype. Nature Medicine. 7: 1028-34. PMID 11533706 DOI: 10.1038/Nm0901-1028  0.513
2001 Donahue RE, Sorrentino BP, Hawley RG, An DS, Chen ISY, Wersto RP. Fibronectin fragment CH-296 inhibits apoptosis and enhances ex vivo gene transfer by murine retrovirus and human lentivirus vectors independent of viral tropism in nonhuman primate CD34+ cells Molecular Therapy. 3: 359-367. PMID 11273778 DOI: 10.1006/Mthe.2001.0269  0.412
2001 Sellers SE, Tisdale JF, Agricola BA, Metzger ME, Donahue RE, Dunbar CE, Sorrentino BP. The effect of multidrug-resistance 1 gene versus neo transduction on ex vivo and in vivo expansion of rhesus macaque hematopoietic repopulating cells. Blood. 97: 1888-91. PMID 11238136 DOI: 10.1182/Blood.V97.6.1888  0.511
2001 Sawai N, Zhou S, Vanin EF, Houghton P, Brent TP, Sorrentino BP. Protection and in vivo selection of hematopoietic stem cells using temozolomide, O6-benzylguanine, and an alkyltransferase-expressing retroviral vector Molecular Therapy. 3: 78-87. PMID 11162314 DOI: 10.1006/Mthe.2000.0223  0.532
2000 Bunting KD, Zhou S, Lu T, Sorrentino BP. Enforced P-glycoprotein pump function in murine bone marrow cells results in expression of side population stem cells in vitro and repopulating cells in vivo Blood. 96: 902-909. PMID 10910903 DOI: 10.1182/Blood.V96.3.902.015K40_902_909  0.529
2000 Giorgianni F, Bridson PK, Sorrentino BP, Pohl J, Blakley RL. Inactivation of aldophosphamide by human aldehyde dehydrogenase isozyme 3. Biochemical Pharmacology. 60: 325-38. PMID 10856427 DOI: 10.1016/S0006-2952(00)00344-0  0.439
2000 Patel DH, Allay JA, Belt JA, Sorrentino BP. Retroviral transfer of the hENT2 nucleoside transporter cDNA confers broad-spectrum antifolate resistance in murine bone marrow cells Blood. 95: 2356-2363. PMID 10733507 DOI: 10.1182/Blood.V95.7.2356.007K31_2356_2363  0.479
2000 Donahue RE, Wersto RP, Allay JA, Agricola BA, Metzger ME, Nienhuis AW, Persons DA, Sorrentino BP. High levels of lymphoid expression of enhanced green fluorescent protein in nonhuman primates transplanted with cytokine-mobilized peripheral blood CD34(+) cells. Blood. 95: 445-52. PMID 10627448 DOI: 10.1182/Blood.V95.2.445  0.479
2000 Bunting KD, Lu T, Kelly PF, Sorrentino BP. Self-selection by genetically modified committed lymphocyte precursors reverses the phenotype of JAK3-deficient mice without myeloablation Human Gene Therapy. 11: 2353-2364. DOI: 10.1089/104303400750038462  0.421
1999 Sorrentino BP, Allay JA, Blakley RL. In vivo selection of hematopoietic stem cells transduced with DHFR-expressing retroviral vectors. Progress in Experimental Tumor Research. 36: 143-61. PMID 10386071 DOI: 10.1159/000061994  0.488
1999 Bunting KD, Galipeau J, Topham D, Benaim E, Sorrentino BP. Effects of retroviral-mediated MDR1 expression on hematopoietic stem cell self-renewal and differentiation in culture Annals of the New York Academy of Sciences. 872: 125-141. PMID 10372117 DOI: 10.1111/J.1749-6632.1999.Tb08459.X  0.531
1999 Bunting KD, Flynn KJ, Riberdy JM, Doherty PC, Sorrentino BP. Virus-specific immunity after gene therapy in a murine model of severe combined immunodeficiency Proceedings of the National Academy of Sciences of the United States of America. 96: 232-237. PMID 9874801 DOI: 10.1073/Pnas.96.1.232  0.384
1999 Moscow JA, Huang H, Carter C, Hines K, Zujewski J, Cusack G, Chow C, Venzon D, Sorrentino B, Chiang Y, Goldspiel B, Leitman S, Read EJ, Abati A, Gottesman MM, et al. Engraftment of MDR1 and NeoR Gene-Transduced Hematopoietic Cells After Breast Cancer Chemotherapy Blood. 94: 52-61. DOI: 10.1182/Blood.V94.1.52.413K35_52_61  0.462
1999 Sorrentino BP, Nienhuis AW. 15 The Hematopoietic System as a Target for Gene Therapy Cold Spring Harbor Monograph Archive. 36: 351-426. DOI: 10.1101/087969528.36.351  0.447
1998 Allay JA, Galipeau J, Blakley RL, Sorrentino BP. Retroviral vectors containing a variant dihydrofolate reductase gene for drug protection and in vivo selection of hematopoietic cells. Stem Cells (Dayton, Ohio). 16: 223-33. PMID 11012166 DOI: 10.1002/Stem.5530160827  0.535
1998 Persons DA, Allay JA, Riberdy JM, Wersto RP, Donahue RE, Sorrentino BP, Nienhuis AW. Use of the green fluorescent protein as a marker to identify and track genetically modified hematopoietic cells. Nature Medicine. 4: 1201-5. PMID 9771757 DOI: 10.1038/2704  0.32
1998 Allay JA, Persons DA, Galipeau J, Riberdy JM, Ashmun RA, Blakley RL, Sorrentino BP. In vivo selection of retrovirally transduced hematopoietic stem cells. Nature Medicine. 4: 1136-43. PMID 9771746 DOI: 10.1038/2632  0.547
1998 Bunting KD, Galipeau J, Topham D, Benaim E, Sorrentino BP. Transduction of murine bone marrow cells with an MDR1 vector enables ex vivo stem cell expansion, but these expanded grafts cause a myeloproliferative syndrome in transplanted mice Blood. 92: 2269-2279. PMID 9746764 DOI: 10.1182/Blood.V92.7.2269.2269_2269_2279  0.537
1998 Mareya SM, Sorrentino BP, Blakley RL. Protection of CCRF-CEM human lymphoid cells from antifolates by retroviral gene transfer of variants of murine dihydrofolate reductase. Cancer Gene Therapy. 5: 225-35. PMID 9694074  0.369
1998 Blakley RL, Sorrentino BP. In vitro mutations in dihydrofolate reductase that confer resistance to methotrexate: potential for clinical application. Human Mutation. 11: 259-63. PMID 9554740 DOI: 10.1002/(Sici)1098-1004(1998)11:4<259::Aid-Humu1>3.0.Co;2-W  0.441
1998 Bunting KD, Sangster MY, Ihle JN, Sorrentino BP. Restoration of lymphocyte function in Janus kinase 3-deficient mice by retroviral-mediated gene transfer. Nature Medicine. 4: 58-64. PMID 9427607 DOI: 10.1038/Nm0198-058  0.473
1997 Patel M, Sleep SE, Lewis WS, Spencer HT, Mareya SM, Sorrentino BP, Blakley RL. Comparison of the protection of cells from antifolates by transduced human dihydrofolate reductase mutants. Human Gene Therapy. 8: 2069-77. PMID 9414255 DOI: 10.1089/Hum.1997.8.17-2069  0.377
1997 Galipeau J, Benaim E, Spencer HT, Blakley RL, Sorrentino BP. A bicistronic retroviral vector for protecting hematopoietic cells against antifolates and P-glycoprotein effluxed drugs. Human Gene Therapy. 8: 1773-83. PMID 9358027 DOI: 10.1089/Hum.1997.8.15-1773  0.463
1997 Allay JA, Spencer HT, Wilkinson SL, Belt JA, Blakley RL, Sorrentino BP. Sensitization of hematopoietic stem and progenitor cells to trimetrexate using nucleoside transport inhibitors. Blood. 90: 3546-54. PMID 9345038 DOI: 10.1182/Blood.V90.9.3546  0.451
1997 Bunting KD, Webb M, Giorgianni F, Galipeau J, Blakley RL, Townsend AJ, Sorrentino BP. Coding region-specific destabilization of mRNA transcripts attenuates expression from retroviral vectors containing class 1 aldehyde dehydrogenase cDNAs. Human Gene Therapy. 8: 1531-43. PMID 9322086 DOI: 10.1089/Hum.1997.8.13-1531  0.426
1997 Persons DA, Allay JA, Allay ER, Smeyne RJ, Ashmun RA, Sorrentino BP, Nienhuis AW. Retroviral-mediated transfer of the green fluorescent protein gene into murine hematopoietic cells facilitates scoring and selection of transduced progenitors in vitro and identification of genetically modified cells in vivo. Blood. 90: 1777-86. PMID 9292510 DOI: 10.1182/Blood.V90.5.1777  0.52
1996 Benaim E, Sorrentino BP. Gene therapy in pediatric oncology Investigational New Drugs. 14: 87-99. PMID 8880396 DOI: 10.1007/Bf00173685  0.423
1996 Spencer HT, Sorrentino BP, Pui CH, Chunduru SK, Sleep SE, Blakley RL. Mutations in the gene for human dihydrofolate reductase: an unlikely cause of clinical relapse in pediatric leukemia after therapy with methotrexate. Leukemia. 10: 439-46. PMID 8642859  0.303
1996 Spencer HT, Sleep SE, Rehg JE, Blakley RL, Sorrentino BP. A gene transfer strategy for making bone marrow cells resistant to trimetrexate. Blood. 87: 2579-87. PMID 8630426 DOI: 10.1182/Blood.V87.6.2579.Bloodjournal8762579  0.476
1996 Sorrentino BP, Spencer HT, Blaklev RL, Allav JA. Protection of hematopoietic cells from antifolate toxicity by a novel variant of human dihydrofolate reductase Experimental Hematology. 24: 1157.  0.432
1995 Brenner MK, Cunningham JM, Sorrentino BP, Heslop HE. Gene transfer into human hemopoietic progenitor cells British Medical Bulletin. 51: 167-191. PMID 7767642 DOI: 10.1093/Oxfordjournals.Bmb.A072945  0.51
1995 Sorrentino BP, McDonagh KT, Woods D, Orlic D. Expression of retroviral vectors containing the human multidrug resistance 1 cDNA in hematopoietic cells of transplanted mice Blood. 86: 491-501. PMID 7605985 DOI: 10.1182/Blood.V86.2.491.Bloodjournal862491  0.517
1995 Orlic D, Anderson S, Biesecker LG, Sorrentino BP, Bodine DM. Pluripotent hematopoietic stem cells contain high levels of mRNA for c- kit, GATA-2, p45 NF-E2, and c-myb and low levels or no mRNA for c-fms and the receptors for granulocyte colony-stimulating factor and interleukins 5 and 7 Proceedings of the National Academy of Sciences of the United States of America. 92: 4601-4605. PMID 7538677 DOI: 10.1073/Pnas.92.10.4601  0.345
1994 O'Shaughnessy JA, Cowan KH, Nienhuis AW, McDonagh KT, Sorrentino BP, Dunbar CE, Chiang Y, Wilson W, Goldspiel B, Kohler D. Retroviral mediated transfer of the human multidrug resistance gene (MDR-1) into hematopoietic stem cells during autologous transplantation after intensive chemotherapy for metastatic breast cancer. Human Gene Therapy. 5: 891-911. PMID 7526902 DOI: 10.1089/Hum.1994.5.7-891  0.401
1994 Dunbar CE, Bodine DM, Sorrentino B, Donahue R, McDonagh K, Cottler-Fox M, O'Shaughnessy J, Cowan K, Carter C, Doren S, Cassell A, Nienhuis AW, Brenner MK. Gene transfer into hematopoietic cells. Implications for cancer therapy Annals of the New York Academy of Sciences. 716: 216-224. PMID 7517651 DOI: 10.1111/J.1749-6632.1994.Tb21714.X  0.4
1993 O'Shaughnessy JA, Cowan KH, Wilson W, Bryant G, Goldspiel B, Gress R, Nienhuis AW, Dunbar C, Sorrentino B, Stewart FM. Pilot study of high dose ICE (ifosfamide, carboplatin, etoposide) chemotherapy and autologous bone marrow transplant (ABMT) with neoR-transduced bone marrow and peripheral blood stem cells in patients with metastatic breast cancer. Human Gene Therapy. 4: 331-54. PMID 8338880 DOI: 10.1089/Hum.1993.4.3-331  0.367
1993 Dunbar CE, Nienhuis AW, Stewart FM, Quesenberry P, O'Shaughnessy J, Cowan K, Cottler-Fox M, Leitman S, Goodman S, Sorrentino BP. Amendment to clinical research projects. Genetic marking with retroviral vectors to study the feasibility of stem cell gene transfer and the biology of hematopoietic reconstitution after autologous transplantation in multiple myeloma, chronic myelogenous leukemia, or metastatic breast cancer. Human Gene Therapy. 4: 205-22. PMID 8098622 DOI: 10.1089/Hum.1993.4.2-205  0.413
1992 Sorrentino BP, Brandt SJ, Bodine D, Gottesman M, Pastan I, Cline A, Nienhuis AW. Selection of drug-resistant bone marrow cells in vivo after retroviral transfer of human MDR1 Science. 257: 99-103. PMID 1352414 DOI: 10.1126/Science.1352414  0.475
1990 Sorrentino B, Ney P, Bodine D, Nienhius AW. A 46 base pair enhancer sequence within the locus activating region is required for induced expression of the gamma-globin gene during erythroid differentiation. Nucleic Acids Research. 18: 2721-31. PMID 2339058 DOI: 10.1093/Nar/18.9.2721  0.399
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